674 results match your criteria Meningococcemia
Hum Vaccin Immunother 2018 Jun 20:1-3. Epub 2018 Jun 20.
c Emory University , Atlanta , GA , United States.
Hum Vaccin Immunother 2018 Jun 8. Epub 2018 Jun 8.
c Public Health General Directorate , Ankara , Turkey.
Life-threatening and fatal meningococcal infections have occurred in patients treated with eculizumab. Herein we describe an 11-year-old boy with atypical hemolytic uremic syndrome treated with eculizumab who developed fatal meningococcemia due to Neisseria meningitidis serogroup Y 16 months after receiving two doses of meningococcal conjugate vaccine (MenACWY-D) while on oral penicillin prophylaxis. Clinicians need to maintain a high index of suspicion for invasive meningococcal disease in patients taking eculizumab treatment, regardless of meningococcal vaccination or antimicrobial prophylaxis status. Read More
Indian J Pathol Microbiol 2018 Apr-Jun;61(2):284-286
Department of Pathology, Command Hospital Air Force, Bengaluru, Karnataka, India.
Acute meningococcemia is characterized by extensive purpurae consisting of both petechiae and ecchymoses. This condition can be rapidly fatal without treatment due to shock and severe consumptive coagulopathy. We report a case of fatal meningococcal septicemia in a military recruit who presented with fever and associated rapidly progressive purpuric rash (purpura fulminans) without any meningeal signs. Read More
PLoS Pathog 2018 04 9;14(4):e1006981. Epub 2018 Apr 9.
Institut Necker Enfants Malades, INSERM U1151, CNRS UMR8253, Paris, France.
Purpura fulminans is a deadly complication of Neisseria meningitidis infections due to extensive thrombosis of microvessels. Although a Disseminated Intra-vascular Coagulation syndrome (DIC) is frequently observed during Gram negative sepsis, it is rarely associated with extensive thrombosis like those observed during meningococcemia, suggesting that the meningococcus induces a specific dysregulation of coagulation. Another specific feature of N. Read More
Hum Vaccin Immunother 2018 May 9;14(5):1146-1160. Epub 2018 May 9.
a Division of Infectious Diseases, Department of Medicine , Emory University School of Medicine , Atlanta , GA , USA.
The control of meningitis, meningococcemia and other infections caused by Neisseria meningitidis is a significant global health challenge. Substantial progress has occurred in the last twenty years in meningococcal vaccine development and global implementation. Meningococcal protein-polysaccharide conjugate vaccines to serogroups A, C, W, and Y (modeled after the Haemophilus influenzae b conjugate vaccines) provide better duration of protection and immunologic memory, and overcome weak immune responses in infants and young children and hypo-responsive to repeated vaccine doses seen with polysaccharide vaccines. Read More
Pan Afr Med J 2017 10;28:123. Epub 2017 Oct 10.
Service d'Accueil des Urgences Pédiatriques, Hôpital d'Enfants Abderrahim Harouchi, Centre Hospitalier Universitaire Ibn Rochd, Casablanca, Maroc.
Introduction: Febrile purpura (FP) is suggestive of meningococcal disease, requiring almost always further investigations and a treatment based on broad spectrum antibiotics. This study aimed to determine the incidence of meningococcal infections as well as their associated clinical signs in children with febrile purpura hospitalized in the emergency department.
Methods: We conducted a descriptive, retrospective study in the pediatric emergency department at the Children's Hospital of Casablanca over a period of 3 years. Read More
Oman Med J 2018 Jan;33(1):61-64
Department of Radiology, Mafraq Hospital, Abu Dhabi, UAE.
Meningococcal meningitis has a wide range of neurological complications. However, cerebral venous sinus thrombosis (CVST) following infection with is uncommon. We report a case of CVST in a 42-year-old male admitted with meningococcal meningitis. Read More
J Infect Chemother 2018 May 17;24(5):398-400. Epub 2018 Jan 17.
Department of Bacteriology I, National Institute of Infectious Disease, 1-23-1 Toyama, Shinjyuku-ku, Tokyo 162-8640, Japan.
Invasive meningococcal disease (IMD) caused by the serogroup W (MenW) sequence type-11 complex strain has recently emerged worldwide. Meningococcal infections due to this strain are associated with high case fatality and often atypical clinical manifestations. However, the annual IMD incidence was low, and MenW is rare in Japan. Read More
MBio 2018 Jan 23;9(1). Epub 2018 Jan 23.
Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany
Sepsis caused by (meningococcus) is a rapidly progressing, life-threatening disease. Because its initial symptoms are rather unspecific, medical attention is often sought too late, i.e. Read More
Intensive Care Med 2018 04 19;44(4):496-497. Epub 2017 Dec 19.
Hematology Department, Hôpital Beaujon, HUPNVS, AP-HP, Clichy, France.
Asian Pac J Trop Med 2017 Nov 28;10(11):1019-1029. Epub 2017 Oct 28.
School of Medicine, New York University - NYU, New York, USA; Departamento de Genética Médica, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
Meningococcal disease is the acute infection caused by Neisseria meningitidis, which has humans as the only natural host. The disease is widespread around the globe and is known for its epidemical potential and high rates of lethality and morbidity. The highest number of cases of the disease is registered in the semi-arid regions of sub-Saharan Africa. Read More
Virulence 2017 11 27;8(8):1808-1819. Epub 2017 Nov 27.
a Institut Necker Enfants-Malades, INSERM U1151, Equipe 11 , Paris , France.
Neisseria meningitidis is the causative agent of cerebrospinal meningitis and that of a rapidly progressing fatal septic shock known as purpura fulminans. Meningococcemia is characterized by bacterial adhesion to human endothelial cells of the microvessels. Host specificity has hampered studies on the role of blood vessels colonization in N. Read More
Hum Vaccin Immunother 2018 May 1;14(5):1138-1145. Epub 2017 Dec 1.
e Institute of Tropical Pathology and Public Health, Federal University of Goias , Goiania , Goias , Brazil.
The 10-valent pneumococcal conjugate vaccine (PCV10) was introduced in the Brazilian National Immunization Program in March 2010, scheduled at 2, 4, and 6 months, with a booster at 12-15 months of age. The meningococcal C conjugate vaccine (MCC) was introduced in November 2010, scheduled at 3 and 5 months, with a booster dose at 12-15 months of age and no catch-up for older age groups. In this interrupted time-series analysis study, we used Brazilian mortality data from 2005 to 2015 for children under five years of age (excluding data from the state of Bahia) to assess the combined impact of these vaccines on the overall burden of meningitis mortality among children aged 0-23 months and 2-4 years, as defined using meningitis and meningococcemia specific International Classification of Diseases - tenth revision codes. Read More
Intern Med 2017 12 11;56(24):3403-3404. Epub 2017 Oct 11.
Division of Infectious Diseases, Musashino Red Cross Hospital, Japan.
Indian J Pediatr 2018 Jul 23;85(7):528-534. Epub 2017 Sep 23.
Department of Pediatrics, Pushpagiri Institute of Medical Sciences and Research Center, Thiruvalla, Kerala, India.
Fever with rashes is one of the commonest clinical problems a general practitioner or pediatrician has to face in day-to-day clinical practice. It can be a mild viral illness or a life-threatening illness like meningococcemia or Dengue hemorrhagic fever or it can be one with a lifelong consequence like Kawasaki disease. It is very important to arrive at a clinical diagnosis as early as possible with the minimum investigational facilities. Read More
P R Health Sci J 2017 Sep;36(3):179-182
Department of Radiology, Aspetar-Orthopaedic and Sports Medicine Hospital, Al Buwairda St. Doha, Qatar.
We report a dramatic case of meningococcal sepsis manifesting as purpura fulminans in an elderly diabetic woman. Hemodynamic instability and severe bilateral cutaneous lesions involving her hands and feet developed rapidly. Specific antibiotic therapy and the administration of inotropic and vasopressor drugs were initiated. Read More
J Clin Microbiol 2017 Dec 13;55(12):3374-3383. Epub 2017 Sep 13.
Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA
, typically a resident of the oro- or nasopharynx and the causative agent of meningococcal meningitis and meningococcemia, is capable of invading and colonizing the urogenital tract. This can result in urethritis, akin to the syndrome caused by its sister species, , the etiologic agent of gonorrhea. Recently, meningococcal strains associated with outbreaks of urethritis were reported to share genetic characteristics with the gonococcus, raising the question of the extent to which these strains contain features that promote adaptation to the genitourinary niche, making them gonococcus-like and distinguishing them from other strains. Read More
Am J Med 2018 Jan 15;131(1):37-40. Epub 2017 Aug 15.
Gastroenterology and Hepatology Unit, Assistance Publique Hôpitaux de Paris (APHP), Hôpital Tenon, Paris, France. Electronic address:
Case Rep Infect Dis 2017 20;2017:6093695. Epub 2017 Jul 20.
Division of Infectious Disease, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Eculizumab is a novel monoclonal antibody that inhibits complement-mediated hemolysis in patients with paroxysmal nocturnal hemoglobinuria (PNH). Complement deficiency is a well-known risk factor for meningococcal infection. We describe a case of a young patient with PNH treated with eculizumab who presented with a life-threatening case of nongroupable meningococcemia. Read More
Medicine (Baltimore) 2017 Jul;96(29):e7573
aUniversité Paris Diderot, Sorbonne Paris Cité, UFR de Médecine bAP-HP, Service de Rhumatologie, Hôpital Bichat cUniversité Paris Diderot, Sorbonne Paris Cité, UFR de Médecine dAP-HP, Service de Bactériologie-Virologie, Hôpital Lariboisière eUniversité Paris Diderot, Sorbonne Paris Cité, UFR de Médecine fAP-HP, Service de Rhumatologie, Hôpital Lariboisière gService de Rhumatologie et Médecine Interne. Centre de Référence des Infections Ostéo-articulaire complexes. Groupe hospitalier Diaconesses Croix St-Simon hUniversité Paris Diderot, Sorbonne Paris Cité, UFR de Médecine iAP-HP, Service de Maladie infectieuses, Hôpital Bichat, Paris, France.
Arthritis secondary to invasive meningococcemia is rare and has been described as a direct result of bacteremia or as immunoallergic-type arthritis, related to the immune complex. Only a few case series have been reported.This multicenter study aimed to describe the clinical characteristics and therapeutic outcomes of arthritis secondary to meningococcal infection. Read More
Crit Care Med 2017 Aug;45(8):e867-e871
1Department of Anesthesia and Reanimation, ZNA Middelheim Hospital, Antwerpen, Belgium.2Department of Cardiothoracic Surgery, ZNA Middelheim Hospital, Antwerpen, Belgium.3Department of Critical Care, ZNA Middelheim Hospital, Antwerpen, Belgium.
Objective: To describe a case of an infected atriobronchial fistula as a late complication after pulmonary vein ablation, leading to septic air emboli and requiring urgent cardiac surgery.
Data Sources: Clinical observation.
Study Selection: Case report. Read More
NASN Sch Nurse 2017 May;32(3):172-177
Attending Pediatric Emergency Medicine Physician, Penn State Hershey Medical Center, Hershey, PA.
Although skin rashes may not necessarily prompt a visit to the school nurse's office, a rash associated with other systemic symptoms, such as fever, headache, difficulty swallowing or breathing, weakness, or abdominal pain, may cause a child to visit your office. This article describes the initial assessment and management of skin rashes in children and adolescents and delineates reasons that may prompt the school nurse to transfer a student with a rash to a local emergency department. Read More
IDCases 2017 10;8:17-18. Epub 2017 Feb 10.
Stryker School of Medicine, Departments of Medicine and Biomedical Sciences, 1000 Oakland Avenue, Kalamazoo, MI 49008, United States.
J Gen Intern Med 2017 Jul 24;32(7):848-849. Epub 2017 Feb 24.
Department of Medicine, Presence Saint Francis Hospital, Evanston, IL, USA.
J Med Case Rep 2016 Dec 20;10(1):362. Epub 2016 Dec 20.
Service de Maladies Infectieuses Aigues, Pôle Maladies Infectieuses, Assistance Publique Hôpitaux de Marseille, CHU Timone, Institut Hospitalo-Universitaire Méditerranée Infection, 13005, Marseille, France.
Background: Meningococcal infection is a multifaceted disease including acute polyarthritis. This presentation should be known by clinicians in order to prevent delay in treatment. We report what we believe to be the first case of an association of parvovirus B19 and meningococcal polyarthritis in a young adult. Read More
Pediatr Infect Dis J 2017 Mar;36(3):296-300
From the *Epidemiology Unit, Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina; †Infectious Disease Unit, Sor María Ludovica Children's Hospital, La Plata, Argentina; ‡Infectious Disease Unit, Victor Vilela Children's Hospital, Rosario, Argentina; §Infectious Disease Unit, Humberto Notti Pediatric Hospital, Mendoza, Argentina; ¶Infectious Disease Unit, Juan Pablo II Pediatric Hospital, Corrientes, Argentina; ‖Infectious Disease Unit, Eva Perón Children's Hospital, Catamarca, Argentina; **Bacteriology Unit, INEI-ANLIS "Dr. Carlos G. Malbrán"; and ††Infectious Disease Unit, FUNCEI, Buenos Aires, Argentina.
Background: Meningococcal disease (MD) is a medical emergency and a serious public health problem. As new meningococcal vaccines become available, MD surveillance is crucial to provide baseline epidemiologic data before implementing preventive measures. We estimated MD incidence and epidemiology in Argentina using hospital-based surveillance. Read More
Metab Brain Dis 2017 04 9;32(2):293-296. Epub 2016 Nov 9.
Pediatric Neurology Unit, Sami Ulus Children Hospital, Ankara, Turkey.
Ethylmalonic encephalopathy (EE) is an autosomal recessive devastating metabolic disorder affecting the brain, gastrointestinal tract, peripheral vessels and rarely the other vascular organs. We report a 10-month-old girl who presented as a meningococcemia clinic but later diagnosed ethylmalonic encephalopathy. Molecular analyses revealed a homozygous c. Read More
J Assoc Physicians India 2016 Feb;64(2):11-12
Febrile patient with thrombocytopenia is commonly encountered by physicians especially during monsoon and perimonsoon period. Infections with protozoa, bacteria and viruses can cause thrombocytopenia with or without disseminated intravascular coagulation. Commonly dengue, malaria, scrub typhus and other rickettsial infections, meningococci, leptospira and certain viral infections present as fever with thrombocytopenia. Read More
J Assoc Physicians India 2016 Jan;64(1):116
Madurai Medical College, Madurai.
J Infect Chemother 2016 Dec 1;22(12):833-836. Epub 2016 Sep 1.
Department of Infectious Diseases, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Japan.
Neisseria meningitidis often causes meningitis and meningococcemia; however, meningococcal pneumonia is quite rare. Herein, we report a case of non-invasive meningococcal pneumonia initially misdiagnosed as pneumonia due to Moraxella catarrhalis on the basis of a Gram stain in a 43-year-old woman with asthma, type 2 diabetes mellitus, and schizophrenia. She visited our hospital following a 3-day history of fever, productive cough, and shortness of breath. Read More
J Paediatr Child Health 2016 Aug;52(8):853-4
Department of Paediatric, Hospital Ramon y Cajal, Madrid, Spain.
Infect Immun 2016 10 19;84(10):3017-23. Epub 2016 Sep 19.
INSERM, U1151, Institut Necker Enfants Malades, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France Laboratoire de Microbiologie Hôpital Necker-Enfants malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
Meningococcal septic shock is associated with profound vasoplegia, early and severe myocardial dysfunction, and extended skin necrosis responsible for a specific clinical entity designated purpura fulminans (PF). PF represents 90% of fatal meningococcal infections. One characteristic of meningococcal PF is the myocardial dysfunction that occurs in the early phase of sepsis. Read More
Arch Pediatr 2016 Jun 25;23(6):595-8. Epub 2016 Apr 25.
Service universitaire de pédiatrie, CHU-CHR La Citadelle, université de Liège, 4000 Liège, Belgique.
Introduction: Neisseria meningitidis is a Gram-negative bacteria that can be highly pathogenic in humans and responsible for life-threatening and acute diseases. In a few cases, it can lead to an atypical form of sepsis-acute, subacute, or chronic-which, even if progression is slower, may carry the same risks for patients as conventional acute forms.
Cases: Case 1 presented with recurrent fever, polyarthralgia, and generalized macular rash. Read More
Immunol Lett 2016 06 14;174:19-22. Epub 2016 Apr 14.
Immunology Division, Hospital Universitari Vall d'Hebron (HUVH), Vall d'Hebron Research Institute (VHIR), Barcelona, Spain; Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.
Complement factor I (CFI) deficiency is typically associated to recurrent infections with encapsulated microorganisms and, less commonly, to autoimmunity. We report a 53-years old male who, in a routine control for non-alcoholic fatty liver disease, presented a flat beta-2 fraction at the capillary protein electropherogram. Patient's clinical records included multiple oropharyngeal infections since infancy and an episode of invasive meningococcal infection. Read More
Enferm Infecc Microbiol Clin 2017 Mar 16;35(3):200-201. Epub 2016 Mar 16.
Servicio de Medicina Intensiva, Hospital General de Segovia, Segovia, España.
Intern Med 2016 15;55(6):567-72. Epub 2016 Mar 15.
Department of General Internal Medicine, Nara City Hospital, Japan.
We mainly refer to the acute setting of meningococcemia. Meningococcemia is an infection caused by Neisseria meningitidis, which has 13 clinically significant serogroups that are distinguishable by the structure of their capsular polysaccharides. N. Read More
J Pediatr 2016 06 6;173:264-264.e2. Epub 2016 Mar 6.
Department of Pediatric Endocrinology, Kocaeli University, School of Medicine, Kocaeli, Turkey.
Am J Emerg Med 2016 May 25;34(5):936.e3-6. Epub 2015 Sep 25.
Department of Emergency Medicine, Division of Pediatric Emergency Medicine, Mayo Clinic, Rochester, MN 55905.
Acute hemorrhagic edema of infancy (AHEI) is a rare acute benign cutaneous leukocytoclastic vasculitis affecting children younger than 24 months of age. Its presentation can be confused with those of urticaria, erythema multiforme, Henoch-Schönlein purpura, idiopathic thrombocytopenia,meningococcemia, Kawasaki disease, and drug rash. We present 2 cases of acute hemorrhagic edema of infancy, discuss the characteristics of AHEI, and compare and contrast AHEI with similar dermatologic presentations. Read More
Case Rep Crit Care 2015 11;2015:953826. Epub 2015 Nov 11.
Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14624, USA.
Neisseria meningitidis is an encapsulated gram negative diplococcus that colonizes the nasopharynx and is transmitted by aerosol or secretions with the majority of cases occurring in infants and adolescents. Meningococcemia carries a high mortality which is in part due to myocarditis. Early recognition and prompt use of antibiotics improve morbidity and mortality. Read More
Rev Chilena Infectol 2015 Oct;32(5):505-16
Introduction: Meningococcal disease (MD) is a major global problem because of its case fatality rate and sequels. Since 2012 cases of serogroup W have increased in Chile, with nonspecific clinical presentation, high case fatality rate and serious consequences.
Objective: To characterize the evolution and outcome of MD cases between January 2012 and March 2013 in Chile. Read More
Rev Med Interne 2016 Mar 31;37(3):206-8. Epub 2015 Aug 31.
Service de dermatologie, centre hospitalier de Saint-Brieuc, 10, rue Marcel-Proust, 22000 Saint-Brieuc, France. Electronic address:
Introduction: Meningococcemia without meningitis is an often under recognized clinical form of invasive Neisseria meningitidis infection.
Case Reports: We report two unusual cases of invasive meningococcal disease who presented with meningococcemia without distinct signs of meningitis or severe sepsis manifestation. In both cases, confirmation of the diagnosis is provided by meningococcal PCR performed on blood or skin lesion biopsy. Read More
Pediatr Infect Dis J 2015 Jun;34(6):670-2
From the Department of Pediatrics, State University of New York Upstate Medical University, Syracuse, NY.
Chronic meningococcemia is a rare diagnosis seen in patients with recurrent fever and rash. We describe a case of chronic meningococcemia in a teenage girl who presented with a recurrent painful rash, without fever, over a period of 8 weeks. Read More
Ned Tijdschr Geneeskd 2015 ;159:A8103
Afd. Kindergeneeskunde: J.C. de Jonge, coassistent kindergeneeskunde; dr. K. Koop, aios kindergeneeskunde; drs. R. Nuboer, kinderarts.
Background: Fever with a rash is a common clinical presentation, which can be caused by various medical conditions.
Case Description: A 14-year old boy presented at the outpatient clinic with a two-week history of fever, myalgia and purpuric skin lesions. Blood cultures showed an infection with Neisseria meningitidis. Read More
Am J Emerg Med 2015 Nov 16;33(11):1713.e3-4. Epub 2015 Mar 16.
Department of Emergency Medicine, Naval Medical Center, San Diego, CA. Electronic address:
Clin Case Rep 2015 Feb 6;3(2):76-80. Epub 2014 Oct 6.
Kitasato Institute for Life Sciences and Laboratory for Antimicrobial Agents, Kitasato University 1-15-1 Kitasato, Sagamihara, Kanagawa, 252-0373, Japan.
We report here a very rare case of primary meningococcal arthritis of the knee joint without clinical features associated with meningococcemia, meningitis, or meningococcal complications. The patient suffered from diabetes mellitus and had experienced two episodes of joint trauma. Intravenous infusion of ampicillin/sulbactam for 18 consecutive days was successful. Read More
Infect Dis (Lond) 2015 Aug 2;47(8):591-2. Epub 2015 Mar 2.
From the 1 National Institute for Communicable Disease Control and Prevention, and State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention , Beijing , PR China.
Invasive meningococcal diseases are rarely caused by capsule null locus (cnl) strains, which are unencapsulated owing to an absence of capsule synthesis genes. Only a few cases of cnl meningococcemia in severely immunocompromised patients have been reported. Here, we describe and discuss the first case of invasive disease in an immunocompetent patient due to a cnl strain of Neisseria meningitidis in China. Read More
Rev Chilena Infectol 2014 Dec;31(6):746-9
Septic vasculitis is a medium and small-vessel vasculitis caused by direct action of pathogens, associated with bacteremia. It is an uncommon condition; clinical manifestations include purpura, ulcers and vesicles-pustules. Most cases of septic vasculitis are related to meningococcemia. Read More
Radiology 2015 May 5;275(2):538-44. Epub 2015 Feb 5.
From the Center for Infectious Disease Imaging (D.J.M., D.A.B.), Department of Radiology and Imaging Sciences, Clinical Center (D.J.M., L.R.F., D.A.B.), and Clinical Center Hospital Epidemiology Service (T.N.P.), National Institutes of Health, 10 Center Dr, Building 10, Room 1C349, Mailstop 1182, Bethesda, MD 20892.
The overlap of early Ebola virus disease (EVD) symptoms (eg, fever, headache, abdominal pain, diarrhea, emesis, and fatigue) with symptoms of other more common travel-related diseases (eg, malaria, typhoid fever, pneumonia, and meningococcemia) may result in delayed diagnosis of EVD before isolation of infected patients. Radiology departments should consider policies for and approaches to decontamination of expensive and potentially easily damaged radiology equipment. In addition, the protection of radiology personnel must be considered during the work-up phase of undiagnosed EVD patients presenting to emergency departments. Read More
G Ital Dermatol Venereol 2015 Feb 16;150(1):73-85. Epub 2015 Jan 16.
Department of Medical Sciences and Human Oncology, Azienda Ospedaliero‑Universitaria, Città della Salute e della Scienza, Turin, Italy -
Sepsis is a potentially life-threatening complication of an infection where cutaneous lesions often represent one of the early signs. A myriad of microorganisms including bacteria, fungi, yeasts, viruses, protozoas, helminths and algae can be implicated. A broad spectrum of clinical and histopathologic findings can be observed in the skin and the common denominator is a thrombotic vasculopathy. Read More