715 results match your criteria Meningococcemia


Pediatric bacterial meningitis and meningococcal disease profile in a Brazilian General Hospital.

Braz J Infect Dis 2020 Jun 26. Epub 2020 Jun 26.

Universidade de São Paulo, Hospital Universitário, Departamento de Pediatria, São Paulo, SP, Brazil. Electronic address:

Objective: To evaluate the clinical and epidemiological profile of bacterial meningitis and meningococcal disease in pediatric patients admitted to a Brazilian Secondary Public Hospital.

Methods: A descriptive observational study was conducted. Microbiologically proven bacterial meningitis or meningococcal disease diagnosed from 2008 to 2018 were included. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.06.001DOI Listing

Meningococcal Infections in Children and Adolescents: Update and Prevention.

Authors:
Rebecca C Brady

Adv Pediatr 2020 Aug 14;67:29-46. Epub 2020 May 14.

Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 6014, Cincinnati, OH 45229-3039, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yapd.2020.03.007DOI Listing

Surgical Treatment of Vitreoretinal Complications During Disseminated Intravascular Coagulation Secondary to Meningococcemia.

Retin Cases Brief Rep 2020 Jun 15. Epub 2020 Jun 15.

Department of Ophthalmology, Percy Military Hospital, 101 Avenue H. Barbusse, 92141 Clamart, France. Tel: +331.41.46.62.74. Fax : +331.41.46.64.91.

Purpose: To report a case of the surgical management of vitreoretinal complications during disseminated intravascular coagulation (DIC) secondary to meningococcemia.

Methods: Case report.

Results: A 25-year-old man presented with loss of vision due to retinal and vitreous hemorrhages during DIC secondary to meningococcemia. Read More

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http://dx.doi.org/10.1097/ICB.0000000000001017DOI Listing

Chronic meningococcemia in a vertically HIV-infected adolescent.

IDCases 2020 21;20:e00764. Epub 2020 Apr 21.

Pediatric Infectious Disease Clinical Care Center of Federal University of São Paulo, Pedro de Toledo Street 924/928 Vila Clementino, Zip Code 04039-002, São Paulo, SP, Brazil.

Chronic meningococcemia is a rare manifestation of meningococcal disease, characterized by a period of more than one week of intermittent or continuous fever, arthralgia and skin lesions without meningitis. It can occur both in previously healthy and immunocompromised patients. The gold standard for the diagnosis is culture isolation of in sterile material. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232083PMC

A severe course of serogroup W meningococcemia in a patient with infantile nephropathic cystinosis.

Hum Vaccin Immunother 2020 May 13:1-2. Epub 2020 May 13.

Faculty of Medicine, Department of Pediatric Intensive Care, Eskisehir Osmangazi University, Eskisehir, Turkey.

We present a 9-month old boy with cystinosis admitted to our hospital with the complaints of vomiting, diarrhea and seizure. While he was hospitalized in a pediatric intensive care unit due to worsening of his signs related to cystinosis, within hours, he suffered complications of septic shock, acute renal failure, and disseminated intravascular coagulation, due to invasive serogroup W disease. Our patient is the first reported case of invasive meningococcal disease with cystinosis. Read More

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http://dx.doi.org/10.1080/21645515.2020.1742508DOI Listing

Meningococcemia Due to Nongroupable Neisseria meningitidis in a Splenectomized Child.

Pediatr Infect Dis J 2020 05;39(5):e57

Pamukkale University School of Medicine, Department of Pediatric Infectious Diseases, Denizli, Turkey, E-mail: Health Sciences University Ankara Hematology and Oncology Research Hospital, Department of Pediatric Infectious Diseases, Ankara, Turkey.

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http://dx.doi.org/10.1097/INF.0000000000002608DOI Listing

Purpuric Epiglottic Lesion in Purpura Fulminans Form of Meningococcemia.

Ear Nose Throat J 2020 Apr 15:145561320920432. Epub 2020 Apr 15.

Department of Pediatric Infectious Diseases, Ankara University School of Medicine, Ankara, Turkey.

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http://dx.doi.org/10.1177/0145561320920432DOI Listing

Induced Fatal Waterhouse-Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure.

Brain Sci 2020 Mar 17;10(3). Epub 2020 Mar 17.

Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan.

-induced acute systemic meningococcal disease is an emergency and a fatal condition that has a high mortality rate. In patients with a fulminant infection, a maculopapular petechial eruption, purpura fulminans, or an ecchymotic lesion are worrisome signs reflecting disseminated intravascular coagulation (DIC) and hint at Waterhouse-Friderichsen syndrome (WFS). Here, we describe a rare case of a patient with a fulminant induced acute systemic meningococcal disease presenting with high-grade fever without meningitis symptoms. Read More

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http://dx.doi.org/10.3390/brainsci10030171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139770PMC

The Inflammatory and Hemostatic Response in Sepsis and Meningococcemia.

Crit Care Clin 2020 Apr 30;36(2):391-399. Epub 2020 Jan 30.

Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. Electronic address:

Meningococcemia is notorious for evasion of the host immune system and its rapid progression to fulminant disease, and serves as a unique model for pediatric sepsis. Illness severity is determined by complex interplays among host, pathogen, and environment. The inflammatory host response, including proinflammatory and anti-inflammatory responses in innate and adaptive immunity, skews toward a proinflammatory state. Read More

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http://dx.doi.org/10.1016/j.ccc.2019.12.005DOI Listing

[Meningococcemia: Different Serotypes in the Same Region].

Mikrobiyol Bul 2020 Jan;54(1):163-170

Ministry of Health, General Directorate of Public Health, National Respiratory Pathogens Reference Laboratory, Ankara, Turkey.

Meningococcal infections are important health problems causing high morbidity and mortality. Neisseria meningitidis have 13 serogroups. A, B, C, Y and W135 are the most common causes of invasive disease among those serogroups. Read More

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http://dx.doi.org/10.5578/mb.68961DOI Listing
January 2020

Acute abdominal pain as the initial manifestation of meningococcemia in adult patient.

Enferm Infecc Microbiol Clin 2020 May 14;38(5):247-248. Epub 2019 Nov 14.

Servicio de Medicina Interna, Hospital Universitario San Juan de Alicante, Spain; Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO), Spain.

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http://dx.doi.org/10.1016/j.eimc.2019.09.008DOI Listing

First case report of fulminant septic shock from meningococcemia associated with Cryptococcus neoformans coinfection in an immunocompetent patient.

Med Mycol Case Rep 2019 Dec 3;26:44-46. Epub 2019 Oct 3.

Infectious Disease Department, Hans Dieter Schmidt Regional Hospital, Joinville, SC, Brazil.

The meningococcal disease manifestation associated with the presence of is rare. There are no reports in the literature about these simultaneous infections in immunocompetent patients. The aim of the present study is to describe the first case of fulminant septic shock by associated with coinfection in an immunocompetent patient. Read More

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http://dx.doi.org/10.1016/j.mmcr.2019.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807376PMC
December 2019
1 Read

A case report of multiple cerebral abscess formation complicating serogroup B Neisseria meningitidis meningitis.

BMC Infect Dis 2019 Oct 21;19(1):863. Epub 2019 Oct 21.

Department of Infectious Diseases, Temple Street Children's University Hospital, Dublin 1, Ireland.

Background: Invasive meningococcal disease (IMD) presenting with meningitis causes significant mortality and morbidity. Suppurative complications of serogroup B meningococcal sepsis are rare and necessitate urgent multidisciplinary management to mitigate long-term morbidity or mortality.

Case Presentation: We present a rare case of invasive meningococcal disease in a 28-month old boy complicated by multiple abscess formation within a pre-existing antenatal left middle cerebral artery territory infarct. Read More

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http://dx.doi.org/10.1186/s12879-019-4509-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802112PMC
October 2019
2 Reads

Analysis of social and medical portrait of children with pertussis, meningococcal infectious, scarlet fever and estimation of their assigned pharmacotherapy.

Wiad Lek 2019 ;72(9 cz 2):1802-1808

Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine.

Objective: Introduction: The level of childhood bacterial diseases incidence does not have a downward trend. The aim: Conduction of a sociological analysis of medical cards for children with pertussis, meningococcal infection (MI), scarlet fever, and evaluation of consumed pharmacotherapy according to real clinical practice in Ukraine.

Patients And Methods: Materials and methods: 1215 medical cards of inpatients; methods: sociological - document analysis, retrospective frequency. Read More

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November 2019
8 Reads

Purpura in the Emergency Room: Two Cases of Sepsis with Cutaneous Manifestations.

Cureus 2019 Jun 23;11(6):e4976. Epub 2019 Jun 23.

Emergency Medicine, AdventHealth East Orlando, Orlando, USA.

Purpura fulminans is a seldom seen manifestation of sepsis in the emergency department (ED). The morbidity and mortality of sepsis have been widely studied and reported; the hallmark of treatment is early recognition and intervention. In extreme cases, sepsis can cause widespread activation of the coagulation cascade further complicating the treatment and recovery from the causative pathogen. Read More

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http://dx.doi.org/10.7759/cureus.4976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706265PMC
June 2019
1 Read

50 Years Ago in TheJournal ofPediatrics: Heparin Therapy in Fulminant Meningococcemia.

J Pediatr 2019 09;212:207

Rainbow Babies and Children's Hospital, Cleveland, Ohio.

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http://dx.doi.org/10.1016/j.jpeds.2019.03.023DOI Listing
September 2019
3 Reads

Myocarditis in fulminant meningococcemia.

Authors:
Hanyu Qin Wei Jiang

Intensive Care Med 2019 11 27;45(11):1655-1656. Epub 2019 May 27.

Medical Intensive Care Unit, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

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http://dx.doi.org/10.1007/s00134-019-05656-4DOI Listing
November 2019
4 Reads

Primary Meningococcal Septic Arthritis Case Report and Literature Review of an Unusual Manifestation of Meningococcal Disease.

Bull Hosp Jt Dis (2013) 2019 Mar;77(2):140-145

Introduction: Primary meningococcal septic arthritis (PMSA) is an unusual manifestation of meningococcal disease. It is defined as the presence of acute septic arthritis without association with meningitis or the classic meningococcemia and isolation of Neisseria meningitidis in synovial fluid and blood culture. Diagnosis and early treatment, combining antibiotic and joint drainage, are fundamental. Read More

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March 2019
6 Reads

Epidemiological burden of meningococcal disease in Latin America: A systematic literature review.

Int J Infect Dis 2019 Aug 11;85:37-48. Epub 2019 May 11.

Medical and Scientific Affairs, Pfizer Vaccines, Buenos Aires, Argentina.

Objective: To evaluate the epidemiological profile of invasive meningococcal disease (IMD), meningococcal meningitis, and Neisseria meningitidis carriers in Latin America.

Methods: A systematic review was conducted to identify and analyze studies published in 2008-2018. Incidence rates, case fatality rates (CFRs), and the relative distribution of cases per serogroup by country were assessed. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.05.006DOI Listing
August 2019
15 Reads

The rash with maculopapules and fever in children.

Clin Dermatol 2019 Mar - Apr;37(2):119-128. Epub 2018 Dec 5.

Dermatology Department, University of CT Health Center, Farmington, Connecticut, USA. Electronic address:

Several medical conditions can cause children to present with fever and a maculopapular rash Although some presentations are benign, others may be medical emergencies, which warrant a prompt diagnosis. We review some of the more common causes of fever and maculopapular dermatitirs, rash including infectious processes (roseola; rubeola; rubella; parvovirus B19; hand, foot, and mouth disease; scarlet fever; meningococcemia; Epstein-Barr virus infection), hypersensitivity reactions (exanthematous drug reactions), and vasculitis syndromes (Kawasaki disease). We have included a diagnostic algorithm to facilitate rapid identification of the etiology of the rash and fever. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0738081X183025
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http://dx.doi.org/10.1016/j.clindermatol.2018.12.005DOI Listing
September 2019
27 Reads

The rash with maculopapules and fever in adults.

Clin Dermatol 2019 Mar - Apr;37(2):109-118. Epub 2018 Dec 5.

Dermatology Department, University of CT Health Center, Farmington, Connecticut, USA. Electronic address:

There is a broad differential diagnosis for the presentation of fever and maculopapular rash in an adult. Although some causative conditions are benign, others are medical emergencies that require prompt diagnosis. We describe various conditions that result in a fever and maculopapular rash in adults. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2018.12.004DOI Listing
September 2019
17 Reads

Chronic meningococcemia.

IDCases 2019 2;15:e00502. Epub 2019 Feb 2.

Infectious Diseases Department, Centro Hospitalar Universitário de São João, Alameda Professor Hernani Monteiro, 4200-319, Porto, Portugal.

The spectrum of -associated clinical entities involves mild forms of disease, without neurological involvement or sepsis, and asymptomatic carrier states. Rarely, bacteremia can be associated with a prolonged fever with or without arthritis, which we designate as chronic meningococcemia. Chronic meningococcemia is an uncommon entity, usually associated to serogroup B . Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370544PMC
February 2019
9 Reads

First Report of a Disease by Rhazes 10 Centuries Ago.

Int J Prev Med 2019 15;10. Epub 2019 Jan 15.

Department of Anesthesiology and Intensive Care Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Abu Bakr Mohammad Ibn Zakariya Al-Razi (865-925 CE), who was known as "Rhazes" in the west, was a famous scientist of medieval ages. He has more than 200 books and treatises. His masterpiece on medicine "" contains around 900 case reports. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_216_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360843PMC
January 2019
13 Reads

The Pathogenic Neisseria Use a Streamlined Set of Peptidoglycan Degradation Proteins for Peptidoglycan Remodeling, Recycling, and Toxic Fragment Release.

Front Microbiol 2019 31;10:73. Epub 2019 Jan 31.

Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States.

and release peptidoglycan (PG) fragments from the cell as the bacteria grow. For these PG fragments are known to cause damage to human Fallopian tube tissue in organ culture that mimics the damage seen in patients with pelvic inflammatory disease. also releases pro-inflammatory PG fragments, but in smaller amounts than those from . Read More

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http://dx.doi.org/10.3389/fmicb.2019.00073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365954PMC
January 2019
10 Reads

Closing the Brief Case: Meningococcemia Leading to a Diagnosis of Complement Deficiency in a 23-Month-Old.

J Clin Microbiol 2019 02 30;57(2). Epub 2019 Jan 30.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/JCM.01516-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355547PMC
February 2019
3 Reads

The Brief Case: Meningococcemia Leading to a Diagnosis of Complement Deficiency in a 23-Month-Old.

J Clin Microbiol 2019 02 30;57(2). Epub 2019 Jan 30.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/JCM.01513-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355521PMC
February 2019
6 Reads

Epidemics of meningococcal meningitis in Northern Nigeria focus on preventive measures.

Ann Afr Med 2018 Oct-Dec;17(4):163-167

Department of Medicine, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.

Throughout the past 200 years, epidemics of meningococcal infection have been noted in Northern Nigeria. Consequently, control of meningococcal meningitis is one of the major priorities in infection control in the region. The proportions of cases of invasive meningococcal disease (IMD) caused by the five common serotypes (A, B, C, Y, and W135) vary among different regions and within specific geographic locations. Read More

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http://www.annalsafrmed.org/text.asp?2018/17/4/163/248397
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http://dx.doi.org/10.4103/aam.aam_62_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330781PMC
August 2019
25 Reads

Meningococcemia Masquerading as a Nonspecific Flu-Like Syndrome.

Case Rep Crit Care 2018 5;2018:2097824. Epub 2018 Nov 5.

Sky Ridge Medical Center, 10099 RidgeGate Parkway, Lone Tree, CO 80124, USA.

is a cause of bacterial meningitis and meningococcemia worldwide. Rarely, it causes invasive disease with significant lifelong sequela if survived. Early clinical recognition is key as meningococcemia is an easily treatable disease, yet mortality is 50% if it is left untreated. Read More

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https://www.hindawi.com/journals/cricc/2018/2097824/
Publisher Site
http://dx.doi.org/10.1155/2018/2097824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241351PMC
November 2018
37 Reads

Chronic meningococcemia: a report of 26 cases and literature review.

Infection 2019 Apr 19;47(2):285-288. Epub 2018 Oct 19.

Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, 2, Rue Henri Le Guilloux, 35033, Rennes Cedex 9, France.

Chronic meningococcemia is defined by blood culture(s) positive for Neisseria meningitidis, symptoms duration > 7 days, and neither meningitis nor shock on admission. This series of 26 consecutive cases illustrates that this is a rare disease (< 5% of meningococcemia, < 0.05 cases per 100,000 inhabitants per year), mostly affecting young adults, males, with no predisposing condition. Read More

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http://link.springer.com/10.1007/s15010-018-1238-x
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http://dx.doi.org/10.1007/s15010-018-1238-xDOI Listing
April 2019
50 Reads

Meningococcemia: rare but life-threatening.

BMJ Case Rep 2018 Oct 17;2018. Epub 2018 Oct 17.

Pediatric Intensive Care, Centro Hospitalar de São João, Porto, Portugal.

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http://dx.doi.org/10.1136/bcr-2018-226914DOI Listing
October 2018
24 Reads

Fulminant meningococcemia in adult caucasian male.

Wiad Lek 2018;71(6):1284-1287

Department Of Internal Medicine And Infectious Diseases, Higher State Educational Establishment "Bukovinian State Medical University", Chernivtsi, Ukraine.

Meningococcal infection remains a leading cause of morbidity and mortality. Based on the sequence of pathophysiological mechanisms and the agent and host factors, a wide spectrum of presentations may be seen. Here we report a non-fatal case of fulminant form of meningococcemia beginning as food poisoning complicated with shock I degree due to partially adrenal hemorrhage in Caucasian adult male. Read More

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June 2019
10 Reads

Renal histological findings in a patient with acute renal injury associated with purpura fulminans: a case report.

J Bras Nefrol 2019 Apr-Jun;41(2):296-299. Epub 2018 Sep 13.

Universidade Estadual de Londrina, Londrina, PR, Brasil.

Introduction: Purpura fulminans (PF) is a rapid progressive thrombotic disease in which hemorrhagic infarction of the skin and disseminated intravascular coagulation (DIC) occurs. It can potentially cause acute kidney injury (AKI). However, there is no description in the medical literature of renal histological findings of PF. Read More

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http://dx.doi.org/10.1590/2175-8239-jbn-2018-0074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699435PMC
February 2020
19 Reads

Chronic meningococcemia presenting with recurrent painful rash and poly-arthralgia without fever.

IDCases 2018 30;14:e00416. Epub 2018 Jun 30.

Clinical Biology Service, IFAC-VIVALIA, 6900 Marche en Famenne, Belgium.

Chronic meningococcemia is an uncommon disorder, representing a diagnostic challenge. Classically, this pathology would be considered in young adults with a history of episodes of fever, disseminated cutaneous vasculitis and arthralgia. Exact and rapid diagnosis is often further challenged by the fact that routine microbiological investigations frequently failed to identify incriminated micro-organism, . Read More

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http://dx.doi.org/10.1016/j.idcr.2018.e00416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125768PMC
June 2018
7 Reads

Invasive Meningococcal Disease due to group C N. meningitidis ST11 (cc11): The Tuscany cluster 2015-2016.

Vaccine 2018 09 30;36(40):5962-5966. Epub 2018 Aug 30.

S.O.C. Malattie Infettive 2 Pistoia - Prato, Azienda USL Toscana-Centro Ospedale San Jacopo, Pistoia, Italy.

Objectives: To describe the cluster of MenC ST11 Invasive Meningococcal Disease (IMD) occurred in Tuscany in the years 2015-2016.

Methods: A retrospective charts analysis of clinical, epidemiological and microbiological aspects of documented IMD was performed. Prognostic factors for death were evaluated. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.08.050DOI Listing
September 2018
13 Reads

Invasive meningococcal disease epidemiology and characterization of Neisseria meningitidis serogroups, sequence types, and clones; implication for use of meningococcal vaccines.

Hum Vaccin Immunother 2019 6;15(1):242-248. Epub 2018 Sep 6.

e Ministry of Health , Government Central Laboratories , Jerusalem , Israel.

Background And Aims: Neisseria meningitidis (N. meningitidis) is a Gram-negative bacterium that can cause life-threatening invasive infections referred to as invasive meningococcal disease (IMD). In the last decade the incidence of IMD in Israel is about 1/100,000 population annually. Read More

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https://www.tandfonline.com/doi/full/10.1080/21645515.2018.1
Publisher Site
http://dx.doi.org/10.1080/21645515.2018.1507261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363162PMC
February 2020
48 Reads

Meningococcemia complicated by myocarditis in a 16-year-old young man: a case report.

Pan Afr Med J 2018 13;29:149. Epub 2018 Mar 13.

Medical Intensive Care Unit, University Hospital F, Hached Sousse, Tunisia.

Fulminant meningococcemia is a relatively rare life-threatening disease caused by Neisseria meningitidis. The clinical presentation is varied, but, when associated with myocarditis, it carries a particularly poor prognosis. We report a case of a patient with fulminant meningococcemia who subsequently developed severe myocardial dysfunction and successfully recovered within a period of 7 days of hospitalization. Read More

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http://dx.doi.org/10.11604/pamj.2018.29.149.13107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057565PMC
August 2018
18 Reads

Fatal Nongroupable Neisseria meningitidis Disease in Vaccinated Patient Receiving Eculizumab.

Emerg Infect Dis 2018 08;24(8)

Patients receiving eculizumab have an increased risk for meningococcal disease, but most reported cases are attributable to encapsulated meningococcal strains. We describe a case in which a nongroupable meningococcal strain, which rarely causes disease in healthy persons, caused fatal disease in an eculizumab recipient despite meningococcal vaccination. Read More

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http://dx.doi.org/10.3201/eid2408.180228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056112PMC
August 2018
34 Reads

[Neisseria meningitidis pneumonia. A case report].

Rev Med Chil 2018 Feb;146(2):249-253

Departamento de Medicina, Hospital Clínico, Universidad de Chile, Santiago, Chile.

Few cases of bacteremic pneumonia by Neisseria meningitidis (NM) have been described worldwide; mostly in elderly patients or those with comorbidities. They appear clinically indistinguishable from other acute infectious pneumoniae, that do not develope the syndrome of meningococcemia. We report a 17-years-old male, without prior medical history, consulting in the emergency department with a 7-day history of productive cough, right pleural pain, fever and dyspnea. Read More

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http://dx.doi.org/10.4067/s0034-98872018000200249DOI Listing
February 2018
16 Reads

Pericarditis due to serogroup W135.

IDCases 2018 7;12:53-55. Epub 2018 Mar 7.

Sakuragaoka Aozora Internal Medicine Clinic, Japan.

is a well-recognized cause of bacterial meningitis. Although less common, can also involve extra-meningeal sites, including the pericardium. The frequency of such extra-meningeal clinical manifestations differs depending on serogroup. Read More

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http://dx.doi.org/10.1016/j.idcr.2018.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010935PMC
March 2018
12 Reads

Fatal meningococcemia due to Neisseria meningitidis serogroup Y in a vaccinated child receiving eculizumab.

Hum Vaccin Immunother 2018 29;14(11):2802. Epub 2018 Jun 29.

c National Reference Laboratory for Respiratory Pathogens, Microbiology Reference Laboratories Department, Public Health Institution of Turkey , Ankara , Turkey.

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http://dx.doi.org/10.1080/21645515.2018.1486157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314419PMC
June 2019
10 Reads

Fatal meningococcal septicemia without meningeal signs, contribution of the peripheral smear in diagnosis: Report of a case.

Indian J Pathol Microbiol 2018 Apr-Jun;61(2):284-286

Department of Pathology, Command Hospital Air Force, Bengaluru, Karnataka, India.

Acute meningococcemia is characterized by extensive purpurae consisting of both petechiae and ecchymoses. This condition can be rapidly fatal without treatment due to shock and severe consumptive coagulopathy. We report a case of fatal meningococcal septicemia in a military recruit who presented with fever and associated rapidly progressive purpuric rash (purpura fulminans) without any meningeal signs. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_209_17DOI Listing
October 2018
45 Reads
0.642 Impact Factor

An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans.

PLoS Pathog 2018 04 9;14(4):e1006981. Epub 2018 Apr 9.

Institut Necker Enfants Malades, INSERM U1151, CNRS UMR8253, Paris, France.

Purpura fulminans is a deadly complication of Neisseria meningitidis infections due to extensive thrombosis of microvessels. Although a Disseminated Intra-vascular Coagulation syndrome (DIC) is frequently observed during Gram negative sepsis, it is rarely associated with extensive thrombosis like those observed during meningococcemia, suggesting that the meningococcus induces a specific dysregulation of coagulation. Another specific feature of N. Read More

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http://dx.doi.org/10.1371/journal.ppat.1006981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908201PMC
April 2018
16 Reads

Progress toward the global control of Neisseria meningitidis: 21st century vaccines, current guidelines, and challenges for future vaccine development.

Hum Vaccin Immunother 2018 05 9;14(5):1146-1160. Epub 2018 May 9.

a Division of Infectious Diseases, Department of Medicine , Emory University School of Medicine , Atlanta , GA , USA.

The control of meningitis, meningococcemia and other infections caused by Neisseria meningitidis is a significant global health challenge. Substantial progress has occurred in the last twenty years in meningococcal vaccine development and global implementation. Meningococcal protein-polysaccharide conjugate vaccines to serogroups A, C, W, and Y (modeled after the Haemophilus influenzae b conjugate vaccines) provide better duration of protection and immunologic memory, and overcome weak immune responses in infants and young children and hypo-responsive to repeated vaccine doses seen with polysaccharide vaccines. Read More

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http://dx.doi.org/10.1080/21645515.2018.1451810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067816PMC
May 2018
16 Reads

[Meningococcal infections associated with febrile purpura among children hospitalized in a Moroccan Hospital: incidence and associated clinical factors].

Pan Afr Med J 2017 10;28:123. Epub 2017 Oct 10.

Service d'Accueil des Urgences Pédiatriques, Hôpital d'Enfants Abderrahim Harouchi, Centre Hospitalier Universitaire Ibn Rochd, Casablanca, Maroc.

Introduction: Febrile purpura (FP) is suggestive of meningococcal disease, requiring almost always further investigations and a treatment based on broad spectrum antibiotics. This study aimed to determine the incidence of meningococcal infections as well as their associated clinical signs in children with febrile purpura hospitalized in the emergency department.

Methods: We conducted a descriptive, retrospective study in the pediatric emergency department at the Children's Hospital of Casablanca over a period of 3 years. Read More

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http://dx.doi.org/10.11604/pamj.2017.28.123.6089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837170PMC
March 2018
24 Reads

Cerebral Venous Sinus Thrombosis in a Patient with Meningococcal Meningitis.

Oman Med J 2018 Jan;33(1):61-64

Department of Radiology, Mafraq Hospital, Abu Dhabi, UAE.

Meningococcal meningitis has a wide range of neurological complications. However, cerebral venous sinus thrombosis (CVST) following infection with is uncommon. We report a case of CVST in a 42-year-old male admitted with meningococcal meningitis. Read More

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http://dx.doi.org/10.5001/omj.2018.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798794PMC
January 2018
13 Reads

Meningococcal meningitis with neurological complications and meningococcemia due to serogroup W sequence type 11 complex.

J Infect Chemother 2018 May 17;24(5):398-400. Epub 2018 Jan 17.

Department of Bacteriology I, National Institute of Infectious Disease, 1-23-1 Toyama, Shinjyuku-ku, Tokyo 162-8640, Japan.

Invasive meningococcal disease (IMD) caused by the serogroup W (MenW) sequence type-11 complex strain has recently emerged worldwide. Meningococcal infections due to this strain are associated with high case fatality and often atypical clinical manifestations. However, the annual IMD incidence was low, and MenW is rare in Japan. Read More

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http://dx.doi.org/10.1016/j.jiac.2017.12.005DOI Listing
May 2018
58 Reads

Complement C5a Receptor 1 Exacerbates the Pathophysiology of Sepsis and Is a Potential Target for Disease Treatment.

mBio 2018 01 23;9(1). Epub 2018 Jan 23.

Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany

Sepsis caused by (meningococcus) is a rapidly progressing, life-threatening disease. Because its initial symptoms are rather unspecific, medical attention is often sought too late, i.e. Read More

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http://mbio.asm.org/lookup/doi/10.1128/mBio.01755-17
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http://dx.doi.org/10.1128/mBio.01755-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784250PMC
January 2018
27 Reads