733 results match your criteria Meningococcemia

Sequelae at Hospital Discharge in 61 Children With Invasive Meningococcal Disease, Chile, 2009-2019.

Pediatr Infect Dis J 2022 Apr 13. Epub 2022 Apr 13.

Department of Pediatrics, Faculty of Medicine, Universidad de Chile, Santiago, Chile.

Background: Invasive meningococcal disease (IMD) is an unpredictable and severe infection caused by Neisseria meningitidis. Its case fatality rate could vary from 9.7% to 26% and up to 36% of survivors may experience long-term sequelae, representing a challenge for public health. Read More

View Article and Full-Text PDF

Waterhouse-Friderichsen Syndrome with Bilateral Adrenal Hemorrhage Associated with Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia in an Adult Patient with History of Intravenous Drug Use.

Thomas Kalinoski

Am J Case Rep 2022 Apr 14;23:e936096. Epub 2022 Apr 14.

Department of Internal Medicine, Olive View - UCLA Medical Center, Sylmar, CA, USA.

BACKGROUND Waterhouse-Friderichsen syndrome, also known as acute adrenal insufficiency due to adrenal gland hemorrhage, is an uncommon and frequently fatal condition classically presenting with fever, shock, rash, and coagulopathy. Although most often associated with Meningococcemia, many other etiologies have been implicated, including reports of Staphylococcus aureus infection on autopsy examinations. This report details an adult intravenous drug user with adrenal hemorrhage associated with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. Read More

View Article and Full-Text PDF

Staphylococcal endocarditis with meningitis and basal ganglia infarcts mimicking meningococcemia.

Clin Case Rep 2022 Mar 1;10(3):e05548. Epub 2022 Mar 1.

Department of Neurology Tribhuvan University Institute of Medicine Kathmandu Nepal.

is one of the common causes of infective endocarditis (IE). IE can present with various neurological complications such as stroke, brain abscess, and meningitis, the mortality rate can be very high in such cases. Read More

View Article and Full-Text PDF

Identification of the nasopharyngeal carriage of Neisseria meningitidis by 16S rRNA Gene sequencing in asymptomatic adolescents and young adults in Cartagena, Colombia (2019-2020).

Braz J Infect Dis 2022 Jan-Feb;26(1):102330. Epub 2022 Feb 15.

Microbiologia Clínica y Ambiental Research Group, University of Cartagena, Cartagena, Colombia; Faculty of Medicine, University of Cartagena, Cartagena, Colombia; Intensive Care and Obstetric Research Group (GRICIO). University of Cartagena, Cartagena, Colombia.

The bacterium Neisseria meningitidis, a strictly human pathogen, can cause meningitis, meningococcemia, sepsis, and death; repeatedly it scause outbreaks around the world. The frequency of asymptomatic carriage is often high in adolescents and young adults, increasing the invasive meningococcal disease risk and likelihood of transmission. However, detailed analyses of meningococcal carriage in this population in Colombia, particularly in coastal areas, are lacking. Read More

View Article and Full-Text PDF

Ethylmalonic encephalopathy masquerading as meningococcemia.

Cold Spring Harb Mol Case Stud 2022 02 24;8(2). Epub 2022 Mar 24.

Monash Genetics, Monash Health, Melbourne, Victoria, Australia.

Ethylmalonic encephalopathy (MIM #602473) is a rare autosomal recessive metabolic condition caused by biallelic variants in (MIM #608451), characterized by global developmental delay, infantile hypotonia, seizures, and microvascular damage. The microvascular changes result in a pattern of relapsing spontaneous diffuse petechiae and purpura, positional acrocyanosis, and pedal edema, hemorrhagic suffusions of mucous membranes, and chronic diarrhea. Here, we describe an instructive case in which ethylmalonic encephalopathy masqueraded as meningococcal septicemia and shock. Read More

View Article and Full-Text PDF
February 2022

Genetic workup as a complementary tool for the diagnosis of primary complement component deficiencies: a multicenter experience.

Eur J Pediatr 2022 May 4;181(5):1997-2004. Epub 2022 Feb 4.

The Jeffrey Modell Foundation Israeli Network for Primary Immunodeficiency, New York, NY, USA.

Diagnosis of primary complement deficiencies requires a high index of suspicion. Thus, susceptible patients are often underdiagnosed and untreated. Here, we present a multicenter experience with two novel inborn errors of the classical complement system. Read More

View Article and Full-Text PDF

Invasive Meningococcal Disease Remains a Health Threat in Vietnam People's Army.

Infect Drug Resist 2021 8;14:5261-5269. Epub 2021 Dec 8.

Department of Foodborne Infectious Disease, Institute of Clinical Infectious Disease, 108 Military Central Hospital, Hanoi, Vietnam.

Objective: Despite strict surveillance, still causes life-threatening invasive meningococcal disease (IMD). The study aimed to describe the prevalence, clinical and subclinical features, and treatment outcomes of IMD among young soldiers of the Vietnam People's Army.

Methods: A prospective, population-based surveillance study was conducted in all Vietnamese military hospitals from January 2014 to June 2021. Read More

View Article and Full-Text PDF
December 2021

Hospitalizations related to meningococcal infection in Spain from 1997 to 2018.

BMC Infect Dis 2021 Dec 6;21(1):1215. Epub 2021 Dec 6.

Department of Medicine & Public Health, Universidad Rey Juan Carlos, Avda. Atenas S/N, 28922, Madrid, Spain.

Background: Baseline hospitalization, mortality, and in-hospital fatality rates for meningococcal infection are required to evaluate preventive interventions, such as the inclusion of the conjugated quadrivalent meningococcal vaccine and serogroup B based protein vaccines.

Methods: All meningococcal infection-related hospitalizations in any diagnostic position in Spain from 1st January 1997 through 31st December 2018 were analysed. The annual hospitalization rate, mortality rate and case-fatality rate were calculated. Read More

View Article and Full-Text PDF
December 2021

Clinical and Laboratory Findings of 12 Children with Invasive Meningococcal Disease in Pediatric Intensive Care Unit.

Crit Care Res Pract 2021 4;2021:9713918. Epub 2021 Sep 4.

Department of Pediatric Intensive Care, Kocaeli University Faculty of Medicine, Umuttepe, Izmit 41001, Turkey.

Introduction: Invasive meningococcal disease (IMD) is a serious infectious disease requiring stay in a pediatric intensive care unit (PICU) that continues to be associated with high morbidity and mortality rates. Prompt recognition, early antibiotic therapy, and aggressive supportive therapies can reduce mortality. We aimed to assess the clinical and laboratory characteristics of children with IMD. Read More

View Article and Full-Text PDF
September 2021

Immunoadsorption therapy for a meningococcemia patient with myocarditis, adrenal hemorrhage, and purpura fulminans: a case report.

Braz J Anesthesiol 2021 Jul 17. Epub 2021 Jul 17.

University of the Health Sciences, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Pediatric Intensive Care Unit, Istanbul, Turkey.

Neisseria meningitidis, also known as meningococcus, is a relatively uncommon cause of invasive infection, but when it occurs, it is frequently severe and potentially life-threatening. A ten-year-old female patient developed a purpuric rash with fever. Upon arrival to the pediatric intensive care department, she was unconscious and in a poor general condition. Read More

View Article and Full-Text PDF

Clinical and molecular characterization of the first culture-confirmed pediatric fulminant meningococcemia case caused by a serogroup Y clonal complex 23 strain in China.

Vaccine 2021 07 16;39(31):4261-4265. Epub 2021 Jun 16.

Department of Microbiology, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, PR China; Department of Microbiology, Shanghai Institutes of Preventive Medicine, Shanghai, PR China. Electronic address:

Serogroup Y Neisseria meningitidis (NmY) is rare in China, and only serogroup A and C meningococcal polysaccharide vaccines (MPVs) are included in the national vaccination schedule. We describe a case of fulminant meningococcemia caused by NmY, which occurred in a pediatric patient (2 years old) for the first time in China, confirmed by culture. Although the boy was treated in time, the dry gangrene in his toes and fingers left him with severe sequelae. Read More

View Article and Full-Text PDF

Temporary Diverting End-Colostomy in Critically Ill Children with Severe Perianal Wound Infection.

Adv Skin Wound Care 2021 Jun;34(6):322-326

At the Ankara University School of Medicine, Turkey, Emrah Gün, MD, is Fellow, Department of Pediatric Critical Care Medicine; Tanil Kendirli, MD, is Professor, Department of Pediatric Critical Care Medicine; Edin Botan, MD, is Fellow, Department of Pediatric Critical Care Medicine; Halil Özdemir, MD, is Associate Professor, Department of Pediatric Infectious Disease; Ergin Çiftçi, MD, is Professor, Department of Pediatric Infectious Disease; Kübra Konca, MD, is Fellow, Department of Pediatric Infectious Disease; Meltem Koloğlu, MD, is Professor, Department of Pediatric Surgery; Gülnur Göllü, MD, is Associate Professor, Department of Pediatric Surgery; Özlem Selvi Can, MD, is Associate Professor, Department of Pediatric Anesthesia; Ercan Tutar, MD, is Professor, Department of Pediatric Cardiology; Ahmet Rüçhan Akar, MD, is Professor, Department of Cardiovascular Surgery, Heart Center, Cebeci Hospitals; and Erdal İnce, MD, is Professor, Department of Pediatric Infectious Disease. Acknowledgments: The authors wish to thank all the pediatric ICU nursing staff for all their efforts and support for our critically ill pediatric patients. The authors have disclosed no financial relationships related to this article. Submitted June 24, 2020; accepted in revised form September 25, 2020.

Abstract: Broad and deep perianal wounds are challenging in both adult and pediatric ICUs. These wounds, if contaminated with gastrointestinal flora, can cause invasive sepsis and death, and recovery can be prolonged. Controlling the source of infection without diverting stool from the perianal region is complicated. Read More

View Article and Full-Text PDF

Investigation of primary immune deficiency after severe bacterial infection in children: A population-based study in western France.

Arch Pediatr 2021 Jul 24;28(5):398-404. Epub 2021 Apr 24.

CHU de Nantes, Department of Pediatrics, Nantes, France.

Background: Infectious diseases are still an important cause of morbidity and mortality in high-income countries and may preferentially affect predisposed children, especially immunocompromised children. We aimed to evaluate the frequency of recommended immunological tests in children with community-onset severe bacterial infection (COSBI) admitted to a pediatric intensive care unit. We also assessed the frequency and described the typology of diagnosed primary immune deficiency (PID). Read More

View Article and Full-Text PDF

Fatal Serogroup B Meningococcemia in a Child Previously Vaccinated With MenACWY-DT Vaccine.

Clin Pediatr (Phila) 2021 05;60(4-5):259-260

Medical School of Ege University, Division of Infectious Disease, Department of Pediatrics, Izmir, Turkey.

View Article and Full-Text PDF

Meningococcal disease epidemiology in Brazil (2005-2018) and impact of MenC vaccination.

Vaccine 2021 01 24;39(3):605-616. Epub 2020 Dec 24.

GSK, Rio de Janeiro, RJ, Brazil.

Background: Meningococcal disease (MD) presents a substantial public health problem in Brazil. Meningococcal C conjugate (MenC) vaccination was introduced into the routine infant immunization program in 2010, followed by adolescent vaccination in 2017. We evaluated changes in national and regional MD incidence and mortality between 2005 and 2018, serogroup distribution and vaccine coverage. Read More

View Article and Full-Text PDF
January 2021

Neonatal meningococcal disease: an update.

J Matern Fetal Neonatal Med 2020 Nov 24:1-6. Epub 2020 Nov 24.

Department of Paediatrics, Patras Medical School, University of Patras, Patras, Greece.

is a common cause of sepsis in the pediatric population but is only rarely observed in neonates. The true incidence of the disease in that age group remains undefined. The purpose of this review is to summarize the published data on meningococcal disease in the neonatal period. Read More

View Article and Full-Text PDF
November 2020

Pediatric bacterial meningitis and meningococcal disease profile in a Brazilian General Hospital.

Braz J Infect Dis 2020 Jul - Aug;24(4):337-342. Epub 2020 Jun 26.

Universidade de São Paulo, Hospital Universitário, Departamento de Pediatria, São Paulo, SP, Brazil. Electronic address:

Objective: To evaluate the clinical and epidemiological profile of bacterial meningitis and meningococcal disease in pediatric patients admitted to a Brazilian Secondary Public Hospital.

Methods: A descriptive observational study was conducted. Microbiologically proven bacterial meningitis or meningococcal disease diagnosed from 2008 to 2018 were included. Read More

View Article and Full-Text PDF
October 2020

Meningococcal Infections in Children and Adolescents: Update and Prevention.

Rebecca C Brady

Adv Pediatr 2020 08 14;67:29-46. Epub 2020 May 14.

Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 6014, Cincinnati, OH 45229-3039, USA. Electronic address:

View Article and Full-Text PDF

Surgical Treatment of Vitreoretinal Complications During Disseminated Intravascular Coagulation Secondary to Meningococcemia.

Retin Cases Brief Rep 2020 Jun 15. Epub 2020 Jun 15.

Department of Ophthalmology, Percy Military Hospital, 101 Avenue H. Barbusse, 92141 Clamart, France. Tel: +331. Fax : +331.

Purpose: To report a case of the surgical management of vitreoretinal complications during disseminated intravascular coagulation (DIC) secondary to meningococcemia.

Methods: Case report.

Results: A 25-year-old man presented with loss of vision due to retinal and vitreous hemorrhages during DIC secondary to meningococcemia. Read More

View Article and Full-Text PDF

Chronic meningococcemia in a vertically HIV-infected adolescent.

IDCases 2020 21;20:e00764. Epub 2020 Apr 21.

Pediatric Infectious Disease Clinical Care Center of Federal University of São Paulo, Pedro de Toledo Street 924/928 Vila Clementino, Zip Code 04039-002, São Paulo, SP, Brazil.

Chronic meningococcemia is a rare manifestation of meningococcal disease, characterized by a period of more than one week of intermittent or continuous fever, arthralgia and skin lesions without meningitis. It can occur both in previously healthy and immunocompromised patients. The gold standard for the diagnosis is culture isolation of in sterile material. Read More

View Article and Full-Text PDF

A severe course of serogroup W meningococcemia in a patient with infantile nephropathic cystinosis.

Hum Vaccin Immunother 2020 11 13;16(11):2787-2788. Epub 2020 May 13.

Faculty of Medicine, Department of Pediatric Intensive Care, Eskisehir Osmangazi University , Eskisehir, Turkey.

We present a 9-month old boy with cystinosis admitted to our hospital with the complaints of vomiting, diarrhea and seizure. While he was hospitalized in a pediatric intensive care unit due to worsening of his signs related to cystinosis, within hours, he suffered complications of septic shock, acute renal failure, and disseminated intravascular coagulation, due to invasive serogroup W disease. Our patient is the first reported case of invasive meningococcal disease with cystinosis. Read More

View Article and Full-Text PDF
November 2020

Meningococcemia Due to Nongroupable Neisseria meningitidis in a Splenectomized Child.

Pediatr Infect Dis J 2020 05;39(5):e57

Health Sciences University Ankara Hematology and Oncology Research Hospital, Department of Pediatric Infectious Diseases, Ankara, Turkey.

View Article and Full-Text PDF

Purpuric Epiglottic Lesion in Purpura Fulminans Form of Meningococcemia.

Ear Nose Throat J 2021 Sep 15;100(8):NP377-NP378. Epub 2020 Apr 15.

Department of Pediatric Infectious Diseases, 63990Ankara University School of Medicine, Ankara, Turkey.

View Article and Full-Text PDF
September 2021

Induced Fatal Waterhouse-Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure.

Brain Sci 2020 Mar 17;10(3). Epub 2020 Mar 17.

Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan.

-induced acute systemic meningococcal disease is an emergency and a fatal condition that has a high mortality rate. In patients with a fulminant infection, a maculopapular petechial eruption, purpura fulminans, or an ecchymotic lesion are worrisome signs reflecting disseminated intravascular coagulation (DIC) and hint at Waterhouse-Friderichsen syndrome (WFS). Here, we describe a rare case of a patient with a fulminant induced acute systemic meningococcal disease presenting with high-grade fever without meningitis symptoms. Read More

View Article and Full-Text PDF

The Inflammatory and Hemostatic Response in Sepsis and Meningococcemia.

Crit Care Clin 2020 Apr 30;36(2):391-399. Epub 2020 Jan 30.

Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. Electronic address:

Meningococcemia is notorious for evasion of the host immune system and its rapid progression to fulminant disease, and serves as a unique model for pediatric sepsis. Illness severity is determined by complex interplays among host, pathogen, and environment. The inflammatory host response, including proinflammatory and anti-inflammatory responses in innate and adaptive immunity, skews toward a proinflammatory state. Read More

View Article and Full-Text PDF

[Meningococcemia: Different Serotypes in the Same Region].

Mikrobiyol Bul 2020 Jan;54(1):163-170

Ministry of Health, General Directorate of Public Health, National Respiratory Pathogens Reference Laboratory, Ankara, Turkey.

Meningococcal infections are important health problems causing high morbidity and mortality. Neisseria meningitidis have 13 serogroups. A, B, C, Y and W135 are the most common causes of invasive disease among those serogroups. Read More

View Article and Full-Text PDF
January 2020

Acute abdominal pain as the initial manifestation of meningococcemia in adult patient.

Enferm Infecc Microbiol Clin (Engl Ed) 2020 May 14;38(5):247-248. Epub 2019 Nov 14.

Servicio de Medicina Interna, Hospital Universitario San Juan de Alicante, Spain; Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO), Spain.

View Article and Full-Text PDF

First case report of fulminant septic shock from meningococcemia associated with Cryptococcus neoformans coinfection in an immunocompetent patient.

Med Mycol Case Rep 2019 Dec 3;26:44-46. Epub 2019 Oct 3.

Infectious Disease Department, Hans Dieter Schmidt Regional Hospital, Joinville, SC, Brazil.

The meningococcal disease manifestation associated with the presence of is rare. There are no reports in the literature about these simultaneous infections in immunocompetent patients. The aim of the present study is to describe the first case of fulminant septic shock by associated with coinfection in an immunocompetent patient. Read More

View Article and Full-Text PDF
December 2019

A case report of multiple cerebral abscess formation complicating serogroup B Neisseria meningitidis meningitis.

BMC Infect Dis 2019 Oct 21;19(1):863. Epub 2019 Oct 21.

Department of Infectious Diseases, Temple Street Children's University Hospital, Dublin 1, Ireland.

Background: Invasive meningococcal disease (IMD) presenting with meningitis causes significant mortality and morbidity. Suppurative complications of serogroup B meningococcal sepsis are rare and necessitate urgent multidisciplinary management to mitigate long-term morbidity or mortality.

Case Presentation: We present a rare case of invasive meningococcal disease in a 28-month old boy complicated by multiple abscess formation within a pre-existing antenatal left middle cerebral artery territory infarct. Read More

View Article and Full-Text PDF
October 2019