mBio 2020 12 15;11(6). Epub 2020 Dec 15.
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
, a major cause of pneumonia, sepsis, and meningitis worldwide, has the nasopharynges of small children as its main ecological niche. Depletion of pneumococci from this niche would reduce the disease burden and could be achieved using small molecules with narrow-spectrum antibacterial activity. We identified the alkylated dicyclohexyl carboxylic acid 2CCA-1 as a potent inducer of autolysin-mediated lysis of , while having low activity against 2CCA-1-resistant strains were found to have inactivating mutations in , known to be required for uptake of host polyunsaturated fatty acids, as well as through inactivation of the transcriptional regulator gene , vital for endogenous, fatty acid synthesis regulation. Read More