Search Our Scientific Publications & Authors

J Neurol Sci 2018 Nov 17;396:232-234. Epub 2018 Nov 17.

Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Japan. Electronic address:

Metab Brain Dis 2018 Dec 5. Epub 2018 Dec 5.

Department of Infectious and Tropical Diseases, Jagiellonian University Medical College, Krakow, Poland.

Neuroinfections are a significant medical problem and can have serious health consequences for patients. Their outcome, if not fatal, can be associated with permanent residual deficits. Cerebrospinal fluid (CSF) examination is commonly used for meningitis confirmation. Read More

Case Rep Crit Care 2018 5;2018:2097824. Epub 2018 Nov 5.

Sky Ridge Medical Center, 10099 RidgeGate Parkway, Lone Tree, CO 80124, USA.

is a cause of bacterial meningitis and meningococcemia worldwide. Rarely, it causes invasive disease with significant lifelong sequela if survived. Early clinical recognition is key as meningococcemia is an easily treatable disease, yet mortality is 50% if it is left untreated. Read More

Stand Genomic Sci 2018 29;13:35. Epub 2018 Nov 29.

1Center of Food Safety and Applied Nutrition, U. S. Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708 USA.

is a Gram-negative opportunistic pathogen that causes life- threatening infantile infections, such as meningitis, septicemia, and necrotizing enterocolitis, as well as pneumonia, septicemia, and urinary tract and wound infections in adults. Here, we report 26 draft genome sequences of , which were obtained from dried spices from the USA, the Middle East, China, and the Republic of Korea. The average genome size of the genomes was 4393 kb, with an average of 4055 protein coding genes, and an average genome G + C content of 56. Read More

Sci Transl Med 2018 Dec;10(470)

Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Tuberculous meningitis (TBM) is a devastating form of tuberculosis (TB), and key TB antimicrobials, including rifampin, have restricted brain penetration. A lack of reliable data on intralesional drug biodistribution in infected tissues has limited pharmacokinetic (PK) modeling efforts to optimize TBM treatments. Current methods to measure intralesional drug distribution rely on tissue resection, which is difficult in humans and generally limited to a single time point even in animals. Read More

Arch Dis Child 2018 Dec 5. Epub 2018 Dec 5.

Department of Paediatrics, Oxford Vaccine Group, University of Oxford, Oxford, UK.

Braz J Infect Dis 2018 Nov 30. Epub 2018 Nov 30.

Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Unidade de Doenças Infecciosas, Porto Alegre, RS, Brazil. Electronic address:

There are limited data on the molecular epidemiology of cryptococcosis in Brazil. Here, we report on the identification of the molecular pattern of the Cryptococcus species that caused meningitis in patients admitted in a Brazilian reference tertiary care hospital, and review the published studies addressing the molecular epidemiology of Cryptococcus in Brazil. Our study has shown the predominance of molecular type VNII in predominantly HIV-infected patients with meningoencephalitis admitted to a tertiary care hospital in the southern area of Brazil. Read More

Clin Infect Dis 2018 Dec 2. Epub 2018 Dec 2.

Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.

Background: Burden estimates of medically- and non-medically-attended influenza-associated illness across syndromes and levels of severity are lacking.

Methods: We estimated the national burden of medically- and non-medically-attended influenza-associated illness among individuals with different clinical presentations (all-respiratory, all-circulatory and non-respiratory/non-circulatory) and levels of severity (mild, severe-non-fatal and fatal) using a combination of case-based (from laboratory-confirmed influenza surveillance) and ecological studies as well as data from healthcare utilization surveys in South Africa during 2013-2015. In addition, we compared estimates of medically-attended influenza-associated respiratory illness obtained from case-based and ecological studies. Read More

Curr Opin Infect Dis 2018 Nov 30. Epub 2018 Nov 30.

Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.

Purpose Of Review: HIV-associated cryptococcal meningitis remains a significant contributor to AIDS-related mortality despite widened access to antiretroviral therapy. Even in clinical trial settings 10-week mortality is roughly 40%. A number of important clinical trials have either recently concluded or are actively recruiting. Read More

Lancet Neurol 2018 Dec 13;17(12):1061-1082. Epub 2018 Nov 13.

Background: Acute meningitis has a high case-fatality rate and survivors can have severe lifelong disability. We aimed to provide a comprehensive assessment of the levels and trends of global meningitis burden that could help to guide introduction, continuation, and ongoing development of vaccines and treatment programmes.

Methods: The Global Burden of Diseases, Injuries, and Risk Factors (GBD) 2016 study estimated meningitis burden due to one of four types of cause: pneumococcal, meningococcal, Haemophilus influenzae type b, and a residual category of other causes. Read More

Lancet Neurol 2018 Dec 13;17(12):1028-1030. Epub 2018 Nov 13.

Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Diseases, Centers for Disease Control and Prevention, Atlanta, GA30333, USA. Electronic address:

Prev Med Rep 2019 Mar 1;13:41-47. Epub 2018 Nov 1.

Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.

Invasive Meningococcal Disease is a deadly, but preventable disease, with community outbreaks occurring at rate of 9.5 per year. Serogroup C Invasive Meningococcal Disease (IMD) community outbreaks in men who have sex with men (MSM) have been reported with greater frequency in large urban areas since 2010. Read More

Front Immunol 2018 16;9:2671. Epub 2018 Nov 16.

Institute of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.

Easy-to-achieve interventions to promote healthy longevity are desired to diminish the incidence and severity of infections, as well as associated disability upon recovery. The dietary supplement palmitoylethanolamide (PEA) exerts anti-inflammatory and neuroprotective properties. Here, we investigated the effect of prophylactic PEA on the early immune response, clinical course, and survival of old mice after intracerebral K1 infection. Read More

Saudi J Biol Sci 2018 Nov 7;25(7):1356-1364. Epub 2015 Nov 7.

Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.

Group B streptococcal infection () is one of the leading causes of life-threatening disease in the early neonatal period, resulting in sepsis, pneumonia, and meningitis. During invasive infections, an excessive release of pro-inflammatory cytokine, such as interleukin-6 (IL-6), thus IL-6 gene is significant, as a diagnostic marker of systemic infection of the newborns. The present study aimed to describe the epidemiology diagnostic of GBS disease in neonatal by phenotypic and genotypic methods. Read More

Oman J Ophthalmol 2018 Sep-Dec;11(3):288-290

Department of Histopathology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan.

Glial heterotopia is a rare congenital mass that often presents as a unilateral mass lesion in or around the nose. Complete surgical excision is the treatment of choice. However, before any surgical intervention for suspected glial heterotopia, distinction should be made both clinically and radiologically from the pathologically related encephalocele to prevent the risk of cerebrospinal fluid leak and meningitis. Read More

Neurol India 2018 Nov-Dec;66(6):1678-1679

Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.

Neurol India 2018 Nov-Dec;66(6):1672-1677

Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: Stroke is common in tuberculous meningitis (TBM), and aspirin has been shown to reduce mortality. A combination of aspirin and corticosteroid may be more useful in this condition.

Aim: To evaluate the effect of aspirin and corticosteroid adjunctive therapy alone or in combination in determining the outcome of TBM. Read More

Neurol India 2018 Nov-Dec;66(6):1550-1571

Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

It has been approximately five decades since Dastur et al., published their seminal work on pathology of tuberculous meningitis (TBM). Though most of their findings find relevance in today's era, there is an important difference; these findings can now be replicated during life using modern day technology. Read More

Vaccine 2018 Nov 29. Epub 2018 Nov 29.

Kitasato Institute for Life Sciences, Laboratory of Viral Infection, 5-9-１ Shirokane Minato-ku, Tokyo 108-8641, Japan. Electronic address:

Vaccine adverse events and controversial safety issues have occurred in recent decades in Japan: aseptic meningitis following the measles-mumps-rubella combined vaccine (MMR), anaphylaxis after immunization with live virus vaccines and inactivated split influenza vaccine, an increased incidence of febrile illness following the simultaneous administration of inactivated vaccines, and chronic pain with neurological illness after immunization with the human papilloma virus vaccine (HPV). Vaccine adverse events are a matter of concern for the public as well as general practitioners; some are within the range of assumptions that adverse reactions after live attenuated vaccines are related to the nature of their parental wild-type viruses. Vaccines stimulate the innate immunity of host immunological defense mechanisms and induce the development of specific acquired immunity. Read More

Semin Hematol 2018 Oct 6;55(4):179-181. Epub 2017 Jul 6.

Department of Biological Hematology, Pitie-Salpetriere Hospital, Paris, France; Centre de Recherche des Cordeliers, Cell Death and Drug Resistance in Lymphoproliferative Disorders, Paris, France.

We here report for the first time that low levels of interleukin (IL)-10 do not exclude lymphomatous meningitis (LM) in B-cell lymphoproliferative disorders (CLPD). Unexpectedly, IL-10 levels and IL-10:IL-6 ratio in CLPD differed from the levels observed in diffuse large B-cell lymphoma (DLBCL). We report the usefulness of adding the IL-10:IL-6 ratio in order to potentially reveal more aggressive lymphomas: either a transformation or an association with another "hidden" lymphoma such as primary CNS lymphoma (PCNSL). Read More

Zhonghua Er Ke Za Zhi 2018 Dec;56(12):915-922

Zunyi Medical University, Zunyi 563003, China.

To explore the clinical features, the serotype distribution and drug resistance of the isolates in patient with invasive pneumococcal disease (IPD). By retrieving the laboratory information system in 18 children's hospitals from 2012 to 2017, the children with IPD were enrolled. (Spn) must be isolated from the sterile sites (blood, cerebrospinal fluid, hydrothorax and joint effusion etc. Read More

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):873-875

Department of Pharmacy, Xiamen Maternity and Child Care Hospital, Xiamen, Fujian, China.

Vancomycin is a first-line drug for treating methicillin-resistant Staphylococcus aureus. Thrombocytopenia is a rare adverse reaction to vancomycin treatment, and there are no reports of vancomycin-induced thrombocytopenia (VIT) in infants. We describe the case of a 3-month-old girl who was diagnosed with purulent meningitis. Read More

PLoS One 2018 5;13(12):e0208151. Epub 2018 Dec 5.

Department of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA, United States of America.

The communities of beneficial bacteria that live in our intestines, the gut microbiome, are important for the development and function of the immune system. Bacteroides species make up a significant fraction of the human gut microbiome, and can be probiotic and pathogenic, depending upon various genetic and environmental factors. These can cause disease conditions such as intra-abdominal sepsis, appendicitis, bacteremia, endocarditis, pericarditis, skin infections, brain abscesses and meningitis. Read More

PLoS One 2018 5;13(12):e0206453. Epub 2018 Dec 5.

London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom.

Improved methods for the detection and characterization of carried Neisseria meningitidis isolates are needed. We evaluated a multiplex PCR algorithm for the detection of a variety of carriage strains in the meningitis belt. To further improve the sensitivity and specificity of the existing PCR assays, primers for gel-based PCR assays (sodC, H, Z) and primers/probe for real-time quantitative PCR (qPCR) assays (porA, cnl, sodC, H, E, Z) were modified or created using Primer Express software. Read More

Curr Opin Neurol 2018 Dec 3. Epub 2018 Dec 3.

Serviço de Neurologia, Hospital das Clínicas da Universidade Federal de Minas Gerais/EBSERH.

Purpose Of Review: To address the important relationships between stroke and infection, focusing on the most frequent infections found in low-income and middle-income countries.

Recent Findings: Stroke is one of the leading causes of mortality and disability worldwide, with a great proportion of the stroke burden occurring in low-income and middle-income countries. Infectious diseases are still a great health problem in developing countries and it is possible that the proportion of infection-related strokes is greater in these nations. Read More

Schweiz Arch Tierheilkd 2018 Dec;160(12):711-717

Institut für Veterinärpathologie, Vetsuisse-Fakultät, Universität Zürich.

Introduction: Autoimmune diseases are of considerable importance in dog breeding. An increased risk of diseases with genetic predisposition is present especially in breeds with a limited genetic diversity. Strict breeding regulations and a high degree of self responsibility of the breeders are essential to prevent these diseases. Read More

Front Immunol 2018 20;9:2674. Epub 2018 Nov 20.

Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, BC, Canada.

The encapsulated bacteria , and (Group B Streptococcus) have been responsible for the majority of severe infections in children for decades, specifically bacteremia and meningitis. Isolates which cause invasive disease are usually surrounded by a polysaccharide capsule, which is a major virulence factor and the key antigen in protective protein-polysaccharide conjugate vaccines. Protection against these bacteria is largely mediated via polysaccharide-specific antibody and complement, although the contribution of these and other components, and the precise mechanisms, vary between species and include opsonophagocytosis and complement-dependent bacteriolysis. Read More

Front Microbiol 2018 20;9:2786. Epub 2018 Nov 20.

Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, United States.

Macrophages play an important role in defending the host against infections by engulfing pathogens and containing them inside the phagosome, which consists of a harsh microbicidal environment. However, many pathogens have developed mechanisms to survive inside macrophages despite this challenge. Group B (GBS), a leading cause of sepsis and meningitis in neonates, is one such pathogen that survives inside macrophages by withstanding phagosomal stress. Read More

Front Neurol 2018 20;9:929. Epub 2018 Nov 20.

Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.

Neonatal bacterial meningitis is a severe infection with high mortality and morbidity. It is necessary to identify factors associated with a high risk of a poor prognosis so that we can prevent them with more appropriate treatments. This study was performed to summarize the prognostic factors known to predict adverse outcomes in neonatal bacterial meningitis. Read More

MBio 2018 Dec 4;9(6). Epub 2018 Dec 4.

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada

The acquisition of iron and the maintenance of iron homeostasis are important aspects of virulence for the pathogenic fungus In this study, we characterized the role of the monothiol glutaredoxin Grx4 in iron homeostasis and virulence in Monothiol glutaredoxins are important regulators of iron homeostasis because of their conserved roles in [2Fe-2S] cluster sensing and trafficking. We initially identified Grx4 as a binding partner of Cir1, a master regulator of iron-responsive genes and virulence factor elaboration in We confirmed that Grx4 binds Cir1 and demonstrated that iron repletion promotes the relocalization of Grx4 from the nucleus to the cytoplasm. We also found that a mutant lacking the GRX domain displayed iron-related phenotypes similar to those of a Δ mutant, including poor growth upon iron deprivation. Read More

Tuberculosis (Edinb) 2018 Dec 6;113:38-42. Epub 2018 Sep 6.

Department of Medicine & Mycobacteriology Laboratory, National Jewish Health, Denver, CO, USA.

Background: Rapid and specific diagnosis of tuberculous meningitis (TBM) is of paramount importance to decrease morbidity and mortality. Therefore, the present study was undertaken to compare the efficacy of Xpert MTB/RIF assay (GXpert) and multiplex PCR (MPCR) using three targets (IS6110, MPB64 and protein B) for diagnosing tuberculous meningitis.

Methods: GXpert and MPCR were performed on cerebrospinal fluid samples of 225 patients out of which 80 were culture-positive confirmed cases of TBM, 100 were 'suspected' cases of TBM and 45 were non-TBM controls. Read More

Medicina (Kaunas) 2018 Dec 3;54(6). Epub 2018 Dec 3.

Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", 5, Via Luciano Armanni, 80138 Naples, Italy.

Vaccination against bacterial pathogens is decisive for preventing invasive meningococcal disease and pediatricians play a pivotal role in vaccination compliance and coverage. The aim of this study was to investigate awareness, attitude, and practices toward the vaccine against Meningococcal B serogroup (4CMenB) among a sample of Italian pediatricians. A cross-sectional study was carried out using an online questionnaire from March to May 2015. Read More

Toxins (Basel) 2018 Dec 1;10(12). Epub 2018 Dec 1.

Department of Infectious Diseases, Israel Institute for Biological Research, P.O. Box 19, Ness Ziona 74100, Israel.

Nonencapsulated (∆pXO2) strains are commonly used as vaccines and for anthrax research, mainly in the mouse model. Previously, we demonstrated that the infection of rabbits, intranasally or subcutaneously, with the spores of a fully virulent strain results in the systemic dissemination of the bacteria, meningitis, and death, whereas ∆pXO2 strains are fully attenuated in this animal model. We used the intravenous inoculation of rabbits to study the pathogenicity of the ∆pXO2 strain infection. Read More

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Department of Pediatrics, Bravis Hospital, Roosendaal, The Netherlands -

Enterovirus (EV) and Parechovirus (HPeV) are a frequent cause of infection in children. This review gives an overview of possible causes for differences in clinical presentation. EV and HPeV can cause a meningitis with or without pleocytosis. Read More

Sci Rep 2018 Dec 3;8(1):17559. Epub 2018 Dec 3.

School of Life Sciences, University of Warwick, Gibbet Hill Road, CV4 7AL, Coventry, UK.

Bacterial infections can be treated with bacteriophages that show great specificity towards their bacterial host and can be genetically modified for different applications. However, whether and how bacteriophages can kill intracellular bacteria in human cells remains elusive. Here, using CRISPR/Cas selection, we have engineered a fluorescent bacteriophage specific for E. Read More

Neurology 2018 Dec;91(23):e2197-e2199

From the Department of Neurology (A.S.D., S.E.C., M.A.B., N.S.R., N.V.) and Department of Medicine, Division of Rheumatology (S.H.U.), Massachusetts General Hospital, and Department of Neurology, Brigham and Women's Hospital (A.S.D., S.E.C.), Harvard Medical School, Boston.

BMC Pediatr 2018 Dec 3;18(1):380. Epub 2018 Dec 3.

Department of Paediatrics, Kingston Hospital, Kingston, London, KT2 7QB, UK.

Background: Recent National Institute for Health and Care Excellence (NICE) CG149 guidelines suggest considering performing a lumbar puncture (LP) to investigate for meningitis in early-onset sepsis in a neonate when a C-reactive protein (CRP) level >10mg/L, but the evidence for this recommendation is poorly defined.

Methods: Data on trust-wide LP protocols, neonatal meningitis incidence, lumbar punctures, and CRP levels seen in cases of neonatal meningitis were asked of all 137 trusts in England that recorded a birth in 2017. Our local Kingston Hospital data on every LP performed was obtained to estimate the specificity of CRP rises. Read More

Medicine (Baltimore) 2018 Nov;97(48):e13458

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Rationale: The transsphenoidal surgical (TS) approach to sellar masses is the preferred surgical route in most cases. Secondary pituitary abscess (PA) following TS is an extremely rare but serious postoperative complication with potentially high disability and mortality.

Patient Concerns: We describe an uncommon case of secondary PA in a 42-year-old woman, who underwent uncomplicated transsphenoidal procedures without cerebrospinal fluid leak, to treat primary Rathke cleft cyst. Read More

JAMA Pediatr 2018 Nov 30. Epub 2018 Nov 30.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Importance: Acute flaccid myelitis (AFM) is an emerging poliolike illness of children whose clinical spectrum and associated pathogens are only partially described. The case definition is intentionally encompassing for epidemiologic surveillance to capture all potential AFM cases. Defining a restrictive, homogenous subpopulation may aid our understanding of this emerging disease. Read More

J Cytol 2018 Oct-Dec;35(4):255-259

Department of Cellular Pathology, Leighton Hospital, Crewe, Cheshire, United Kingdom.

Introduction: Neoplastic involvement of cerebrospinal fluid (CSF) secondary to known or unknown primaries elsewhere is a poor prognostic factor and is equivalent to stage IV disease.

Aim: The aim of the study is to analyse the cytological features of neoplastic meningitis in a tertiary care center.

Materials And Methods: A retrospective study of 400 consecutive CSF samples was done in the cytology laboratory of our hospital. Read More

Pediatr Neonatol 2018 Nov 1. Epub 2018 Nov 1.

Division of Pediatric Neurosurgery, Chang Gung Children's Hospital, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.

Lancet Infect Dis 2018 Nov 26. Epub 2018 Nov 26.

Paediatric Infectious Diseases Research Group & Vaccine Institute, St George's University of London and St George's University Hospitals NHS Trust, London, UK.

Background: Group B streptococcus is a leading cause of serious infection in young infants in many countries worldwide. We aimed to define the burden and clinical features of invasive group B streptococcal disease in infants younger than 90 days in the UK and Ireland, together with the characteristics of disease-causing isolates.

Methods: Prospective, active national surveillance of invasive group B streptococcal disease in infants younger than 90 days was done from April 1, 2014, to April 30, 2015, through the British Paediatric Surveillance Unit, microbiology reference laboratories, and national public health agencies in the UK and Ireland. Read More

J Microbiol Immunol Infect 2018 Nov 22. Epub 2018 Nov 22.

Department of Infectious Disease, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. Electronic address:

Vaccine 2018 Dec 26;36(52):8131-8137. Epub 2018 Nov 26.

National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China. Electronic address:

Background: China's immunization program is one of the oldest and largest in the world. Rates of vaccine-preventable diseases (VPD) are comparable to those in high-income countries. The program's evolution has been characterized by ambitious target setting and innovative strategies that have not been widely described. Read More

BMC Infect Dis 2018 Nov 1;18(1):544. Epub 2018 Nov 1.

Department of Zoonotic, Food- and Waterborne Infections, Norwegian Institute of Public Health, Oslo, Norway.

Background: Classification of pathogenic Escherichia coli (E. coli) has traditionally relied on detecting specific virulence associated genes (VAGs) or combinations thereof. For E. Read More

J Neurosurg Spine 2018 Nov 1:1-5. Epub 2018 Nov 1.

The pathogenesis of thoracic ventral intradural spinal arachnoid cyst (ISAC) is unknown due to its extremely low incidence. In addition, its surgical treatment is complicated because of the ventral location, large craniocaudal extension, and frequent coexistence of syringomyelia. The optimal surgical strategy for thoracic ventral ISAC remains unclear and continues to be a matter of debate. Read More

Mol Ther Nucleic Acids 2018 Oct 26;13:651-664. Epub 2018 Oct 26.

The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, Hubei 430070, China; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China. Electronic address:

With their essential regulatory roles in gene expression and high abundance in the brain, circular RNAs (circRNAs) have recently attracted considerable attention. Many studies have shown that circRNAs play important roles in the pathology of CNS diseases, but whether circRNAs participate in E. coli-induced bacterial meningitis is unclear. Read More

J Stomatol Oral Maxillofac Surg 2018 Nov 26. Epub 2018 Nov 26.

Department of Maxillofacial Surgery, Nantes University Hospital, 1 place Alexis-Ricordeau, 44093 Nantes cedex 1, France.

Fractures of the frontal sinus are classified according to the topography (anterior wall, posterior wall or both), the displacement, and the presence of associated lesions (wound, nasofrontal duct injury, rhinorrhea). Isolated fractures of the anterior wall require surgical management, if the displacement is over 4 mm, to restore the forehead symmetry, to maintain the sinus ventilation and to avoid long-term complications (sinusitis, mucocele, meningitis…). Coronal incision is commonly performed but less invasive techniques are more and more used. Read More