7,371 results match your criteria Meningitis Meningococcal


The Global Meningitis Genome Partnership.

J Infect 2020 Jun 29. Epub 2020 Jun 29.

WHO, Geneva, Switzerland.

Genomic surveillance of bacterial meningitis pathogens is essential for effective disease control globally, enabling identification of emerging and expanding strains and consequent public health interventions. While there has been a rise in the use of whole genome sequencing, this has been driven predominately by a subset of countries with adequate capacity and resources. Global capacity to participate in surveillance needs to be expanded, particularly in low and middle-income countries with high disease burdens. Read More

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http://dx.doi.org/10.1016/j.jinf.2020.06.064DOI Listing

Pediatric bacterial meningitis and meningococcal disease profile in a Brazilian General Hospital.

Braz J Infect Dis 2020 Jun 26. Epub 2020 Jun 26.

Universidade de São Paulo, Hospital Universitário, Departamento de Pediatria, São Paulo, SP, Brazil. Electronic address:

Objective: To evaluate the clinical and epidemiological profile of bacterial meningitis and meningococcal disease in pediatric patients admitted to a Brazilian Secondary Public Hospital.

Methods: A descriptive observational study was conducted. Microbiologically proven bacterial meningitis or meningococcal disease diagnosed from 2008 to 2018 were included. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.06.001DOI Listing

Meningococcal Infections in Children and Adolescents: Update and Prevention.

Authors:
Rebecca C Brady

Adv Pediatr 2020 Aug 14;67:29-46. Epub 2020 May 14.

Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 6014, Cincinnati, OH 45229-3039, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yapd.2020.03.007DOI Listing

Surveillance system assessment in Guinea: Training needed to strengthen data quality and analysis, 2016.

PLoS One 2020 25;15(6):e0234796. Epub 2020 Jun 25.

RTI International, Research Triangle Park, North Carolina, United States of America.

The 2014-2016 Ebola virus disease outbreak revealed the fragility of the Guinean public health infrastructure. As a result, the Guinean Ministry of Health is collaborating with international partners to improve compliance with the International Health Regulations and work toward the Global Health Security Agenda goals, including enhanced case- and community-based disease surveillance. We assessed the case-based disease surveillance system during October 1, 2015-March 31, 2016, in the Boffa prefecture of Guinea. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234796PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316275PMC

Case Manifestations and Public Health Response for Outbreak of Meningococcal W Disease, Central Australia, 2017.

Emerg Infect Dis 2020 Jul;26(7):1355-1363

Neisseria meningitidis serogroup W has emerged as an increasingly common cause of invasive meningococcal disease worldwide; the average case-fatality rate is 10%. In 2017, an unprecedented outbreak of serogroup W infection occurred among the Indigenous pediatric population of Central Australia; there were 24 cases over a 5-month period. Among these cases were atypical manifestations, including meningococcal pneumonia, septic arthritis, and conjunctivitis. Read More

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http://dx.doi.org/10.3201/eid2607.181941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323526PMC

Detection of Ciprofloxacin-Resistant, β-Lactamase-Producing Neisseria meningitidis Serogroup Y Isolates - United States, 2019-2020.

MMWR Morb Mortal Wkly Rep 2020 Jun 19;69(24):735-739. Epub 2020 Jun 19.

Meningococcal disease is a sudden-onset, life-threatening illness caused by the bacterium Neisseria meningitidis. Prompt empiric antibiotic treatment can reduce morbidity and mortality among patients, and antibiotic prophylaxis can prevent secondary disease in close contacts. Historically, N. Read More

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http://dx.doi.org/10.15585/mmwr.mm6924a2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302475PMC

"I think meningitis is a virus, while septicaemia might be caused by bacteria." A study of vaccination views, disease awareness and MenACWY and MMR uptake among freshers at a London university.

Int J Adolesc Med Health 2020 Jun 10. Epub 2020 Jun 10.

UCL Great Ormond Street Institute of Child Health, London, UK.

Background University students are at particular risk of invasive meningococcal disease (IMD). Group W, an aggressive strain, is increasing in prevalence and the high case-fatality rate is concerning. Adolescents have been offered the MenACWY vaccine since 2015. Read More

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http://dx.doi.org/10.1515/ijamh-2019-0254DOI Listing

serogroup C causing primary polyarthritis in an octogenarian.

BMJ Case Rep 2020 Jun 11;13(6). Epub 2020 Jun 11.

Microbiology, NHS Forth Valley, Larbert, UK

A man in his 80s presented to the hospital with a 36-hour history of fever, myalgia, bilateral shoulder and right knee pain. Joint fluid aspirates from his shoulders and right knee isolated Gram-negative diplococci. After failing to grow on standard and selective media, was identified by 16s PCR and subsequently typed as serogroup C. Read More

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http://dx.doi.org/10.1136/bcr-2019-233378DOI Listing

COVID-19 effects on national health system response to a local epidemic: the case of cerebrospinal meningitis outbreak in Ghana.

Pan Afr Med J 2020 30;35(Suppl 2):14. Epub 2020 Apr 30.

Department of Health Policy Planning and Management, School of Public Health, University of Health and Allied Sciences, Hohoe, Ghana.

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http://dx.doi.org/10.11604/pamj.2020.35.2.23138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266470PMC

COVID-19 and lessons learned from the pandemic wave of meningococcal meningitis (1985-1990).

Sudan J Paediatr 2020 ;20(1):77-88

Editor-in-Chief, Sudanese Journal of Paediatrics, Khartoum, Sudan.

A novel coronavirus was first identified in late 2019 to cause an outbreak of acute respiratory illness in Wuhan city in China. The disease was designated COVID-19 (coronavirus disease 2019) by the World Health Organization (WHO) in February 2020. Worldwide, the infection spread affecting more than 3 million confirmed cases, mainly in Europe and USA, and was characterised by the WHO as a pandemic in March 2020. Read More

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http://dx.doi.org/10.24911/SJP.106-1587809750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282429PMC
January 2020

The everchanging epidemiology of meningococcal disease worldwide and the potential for prevention through vaccination.

J Infect 2020 Jun 3. Epub 2020 Jun 3.

Immunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, London, UK; Paediatric Infectious Diseases Research Group (PIDRG), St. George's University of London, Cranmer Terrace, London SW17 0RE, UK. Electronic address:

Neisseria meningitidis is a major cause of bacterial meningitis and septicaemia worldwide and is associated with high case fatality rates and serious life-long complications among survivors. Twelve serogroups are recognised, of which six (A, B, C, W, X and Y) are responsible for nearly all cases of invasive meningococcal disease (IMD). The incidence of IMD and responsible serogroups vary widely both geographically and over time. Read More

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http://dx.doi.org/10.1016/j.jinf.2020.05.079DOI Listing

Patients With Inflammatory Bowel Diseases Are at Higher Risk for Meningitis.

J Clin Gastroenterol 2020 May 29. Epub 2020 May 29.

Multidisciplinary Center for Inflammatory Bowel Diseases.

Background: The epidemiology of meningitis is unknown in inflammatory bowel disease (IBD) patients.

Goals: We aimed to determine the incidence of and risk factors for meningitis in IBD patients.

Study: We conducted a retrospective cohort and nested case-control study in the Quintiles IMS Legacy PharMetrics Adjudicated Claims Database from January 2001 to June 2016. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001365DOI Listing

Recurrent meningococcal meningitis with complement 6 (C6) deficiency: A case report.

Medicine (Baltimore) 2020 May;99(21):e20362

Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Republic of Korea.

Rationale: Late complement deficiency increases susceptibility to meningococcal disease and recurrent infections. In Korea, 5 case reports have described meningococcal disease with complement deficiency. However, C6 deficiency has not been described previously. Read More

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http://dx.doi.org/10.1097/MD.0000000000020362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249908PMC

Lessons from mass vaccination response to meningococcal B outbreaks at US universities.

Postgrad Med 2020 Jun 1:1-10. Epub 2020 Jun 1.

Medical Development, Scientific & Clinical Affairs, Pfizer Vaccines, Pfizer Inc , Collegeville, PA, USA.

College students in the United States are at an increased risk for meningococcal serogroup B disease or MenB, which causes the majority of invasive meningococcal disease in the country among adolescents and young adults (62%) and also across all age groups (36%) as of 2018. Approximately one-third of MenB cases among college students occur during campus outbreaks, which trigger substantial public health concern and costs associated with conducting rapid mass vaccination campaigns in an emergency setting. Eleven US college outbreaks of MenB disease have occurred since the initial licensure and recommendation of two MenB vaccines in 2014/2015; both vaccines have been used as part of outbreak responses on campuses, but vaccine coverage and multidose series completion among the general adolescent population are very low (approximately 17% of 17-year-olds in the United States received ≥1 dose in 2018). Read More

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http://dx.doi.org/10.1080/00325481.2020.1766265DOI Listing

: analysis of pili and LPS in emerging Brazilian strains.

Ther Adv Vaccines Immunother 2020 8;8:2515135520919195. Epub 2020 May 8.

Departament of Immunology, Adolfo Lutz Institute, Dr Arnaldo Avenue 355, 11 floor, São Paulo, SP 01246-902, Brazil.

Background: is the main cause of bacterial meningitis in Brazil, where the main serogroups isolated are B and C; however, the serogroup W has recently emerged. LPS and type IV pili are important virulence factors that increase meningococci pathogenicity.

Methods: The characterization of Lipopolysaccharide (LPS) and type IV pili in 19 meningococci strains of serogroup B, 21 of serogroup C, 45 of serogroup W and 28 of serogroup Y, isolated in Brazil between 2011 and 2017, was conducted using the Enzyme-linked Immunosorbent Assay (Dot- ELISA) technique and monoclonal antibodies. Read More

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http://dx.doi.org/10.1177/2515135520919195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225800PMC

Chronic meningococcemia in a vertically HIV-infected adolescent.

IDCases 2020 21;20:e00764. Epub 2020 Apr 21.

Pediatric Infectious Disease Clinical Care Center of Federal University of São Paulo, Pedro de Toledo Street 924/928 Vila Clementino, Zip Code 04039-002, São Paulo, SP, Brazil.

Chronic meningococcemia is a rare manifestation of meningococcal disease, characterized by a period of more than one week of intermittent or continuous fever, arthralgia and skin lesions without meningitis. It can occur both in previously healthy and immunocompromised patients. The gold standard for the diagnosis is culture isolation of in sterile material. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232083PMC

The epidemiology of invasive meningococcal disease and the utility of vaccination in Malta.

Eur J Clin Microbiol Infect Dis 2020 May 16. Epub 2020 May 16.

Department of Pathology, Mater Dei Hospital, Tal-Qroqq, Msida, MSD2090, Malta.

Invasive meningococcal disease (IMD) is a vaccine-preventable devastating infection that mainly affects infants, children and adolescents. We describe the population epidemiology of IMD in Malta in order to assess the potential utility of a meningococcal vaccination programme. All cases of microbiologically confirmed IMD in the Maltese population from 2000 to 2017 were analysed to quantify the overall and capsular-specific disease burden. Read More

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http://dx.doi.org/10.1007/s10096-020-03914-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229431PMC

Estimates of the reproductive numbers and demographic reconstruction of outbreak associated with C:P1.5-1,10-8:F3-6:ST-11(cc11) Neisseria meningitidis strains.

Infect Genet Evol 2020 May 11:104360. Epub 2020 May 11.

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy. Electronic address:

Background: Neisseria meningitidis can cause sporadic cases and outbreaks of invasive disease, including meningitis and sepsis. The meningococcal serogroup C (MenC) is the second most common serogroup in Italy after MenB. In this study we have estimated the reproductive numbers and the demographic reconstruction on the genomes of invasive N. Read More

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http://dx.doi.org/10.1016/j.meegid.2020.104360DOI Listing

Immunogenicity and safety of a quadrivalent meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT) in ≥56-year-olds: A Phase III randomized study.

Vaccine 2020 Jun 6;38(28):4405-4411. Epub 2020 May 6.

Sanofi Pasteur, Swiftwater, PA, USA. Electronic address:

Background: Invasive meningococcal disease has a high mortality rate in individuals aged ≥56 years, but no vaccine is currently licensed in the USA for this age group. This study assessed the safety and immunogenicity of an investigational quadrivalent meningococcal tetanus toxoid conjugate vaccine (MenACYW-TT) compared with a meningococcal quadrivalent polysaccharide vaccine (MPSV4) in this age group.

Methods: This was a Phase III, modified double-blind, randomized, non-inferiority study (NCT02842866) across 35 clinical sites in the USA and Puerto Rico in individuals aged ≥56 years. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.04.067DOI Listing

HIV infection is associated with increased meningococcal carriage acquisition amongst first-year students in two South African universities.

Clin Infect Dis 2020 May 5. Epub 2020 May 5.

Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, a Division of the National Health Laboratory Service, Johannesburg, South Africa.

Background: Invasive meningococcal disease clusters occur amongst university students and may reflect higher carriage prevalence amongst this population. We aimed to measure meningococcal carriage prevalence, acquisition and risk factors amongst first-year university students in South Africa, a middle-income country.

Methods: In summer to autumn 2017, after consenting to participate, we collected oropharyngeal swabs and questionnaires on carriage risk factors and tested students for HIV infection at two universities, during registration week (survey one) and 6-8 weeks later (survey two). Read More

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http://dx.doi.org/10.1093/cid/ciaa521DOI Listing

Meningococcal infections among refugees and immigrants: silent threats of past, present and future.

Hum Vaccin Immunother 2020 Apr 29:1-6. Epub 2020 Apr 29.

Vaccine Evaluation Unit, Public Health England, Manchester, UK.

Globally, there is an increasing number of international migrants. The majority are forced displaced refugees and children unaccompanied by a caregiver, and have limited access to essential public health interventions. Routine vaccination might be interrupted or be incomplete due to conflict areas with limited public health services or a long-unplanned journey. Read More

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http://dx.doi.org/10.1080/21645515.2020.1744979DOI Listing

Cuban Meningococcal Vaccine VA-MENGOC-BC:30 Years of Use and Future Potential.

MEDICC Rev 2019 Oct;21(4):19-27

Every year, meningococcal infection by Neisseria meningitidis causes over 500,000 cases and 85,000 deaths in the world, with 20% of survivors suffering sequelae. In Cuba its incidence in 1980 reached 5.9 cases per 100,000 population; about 80% of cases were serogroup B, prompting health authorities to declare meningococcal disease the country's main public health problem. Read More

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October 2019

Serogroup A meningococcal conjugate vaccines: building sustainable and equitable vaccine strategies.

Expert Rev Vaccines 2020 May 29;19(5):455-463. Epub 2020 Apr 29.

Division of Infectious Diseases, Department of Medicine Emory University School of Medicine , Atlanta, Georgia, USA.

Introduction: For well over 100 years, meningococcal disease due to serogroup A (MenA) has caused severe epidemics globally, especially in the meningitis belt of sub-Saharan Africa.

Areas Covered: The article reviews the background and identification of MenA, the global and molecular epidemiology of MenA, and the outbreaks of MenA in the African meningitis belt. The implementation (2010) of an equitable MenA polysaccharide-protein conjugate vaccine (Ps-TT, MenAfriVac) and the strategy to control MenA in sub-Saharan Africa is described. Read More

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http://dx.doi.org/10.1080/14760584.2020.1760097DOI Listing

Characteristics and outcome of spontaneous bacterial meningitis in patients with diabetes mellitus.

BMC Infect Dis 2020 Apr 20;20(1):292. Epub 2020 Apr 20.

Infectious Diseases Unit (Department of Internal Medicine), Hospital de la Santa Creu i Sant Pau - Institut d'Investigació Biomèdica Sant Pau. Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: Studies on bacterial meningitis in diabetics patients versus non-diabetics are scarce. In patients with diabetes, bacterial meningitis may have a different presentation, etiology and course. We analyzed and compared the characteristics and outcome of spontaneous BM in adult patients with and without diabetes mellitus (DM). Read More

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http://dx.doi.org/10.1186/s12879-020-05023-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171854PMC

Sharing of Individual Participant Data from Clinical Trials: General Comparison and HIV Use Case.

AMIA Annu Symp Proc 2019 4;2019:647-654. Epub 2020 Mar 4.

Lister Hill National Center for Biomedical Communication, National Library of Medicine, NIH Bethesda, MD.

Sharing of individual participant data is encouraged by the International Committee of Medical Journal Editors. We analyzed clinical trial registry data from ClinicalTrials.gov (CTG) and determined the proportion of trials sharing de-identified Individual Participant Data (IPD). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153161PMC

A new roadmap for meningitis.

Authors:
The Lancet

Lancet 2020 04;395(10232):1230

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http://dx.doi.org/10.1016/S0140-6736(20)30865-5DOI Listing

One disease, two vaccines: challenges in prevention of meningococcal disease.

Med J Aust 2020 Jun 12;212(10):453-456.e1. Epub 2020 Apr 12.

National Centre for Immunisation Research and Surveillance, Sydney Children's Hospital Network, Sydney, NSW.

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http://dx.doi.org/10.5694/mja2.50567DOI Listing

Insights on Population Structure and Within-Host Genetic Changes among Meningococcal Carriage Isolates from U.S. Universities.

mSphere 2020 04 8;5(2). Epub 2020 Apr 8.

Meningitis and Vaccine Preventable Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

In 2015 and 2016, meningococcal carriage evaluations were conducted at two universities in the United States following mass vaccination campaigns in response to serogroup B (NmB) disease outbreaks. A simultaneous carriage evaluation was also conducted at a university near one of the outbreaks, where no NmB cases were reported and no mass vaccination occurred. A total of ten cross-sectional carriage evaluation rounds were conducted, resulting in 1,514 meningococcal carriage isolates collected from 7,001 unique participants; 1,587 individuals were swabbed at multiple time points (repeat participants). Read More

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http://dx.doi.org/10.1128/mSphere.00197-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142301PMC

The Origin of the Idea That Herpes Labialis Is of Prognostic Importance in Bacterial Meningitis.

Authors:
Peter J Koehler

Eur Neurol 2020 27;83(1):105-110. Epub 2020 Mar 27.

Faculty of Health, Medicine and Life Sciences, Maastricht University, Wijlre, The Netherlands,

Objective: The aim of the work was to study the origin of the idea that herpes labialis (HL) in patients with pneumonia and meningitis was believed to be of prognostic importance.

Background: HL is caused by a primary infection or reactivation of herpes simplex type I. In the past, it has been related to pneumonia and meningitis; moreover, HL was believed to be of prognostic importance. Read More

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http://dx.doi.org/10.1159/000506681DOI Listing

Multicenter Hospital-Based Prospective Surveillance Study of Bacterial Agents Causing Meningitis and Seroprevalence of Different Serogroups of Neisseria meningitidis, Haemophilus influenzae Type b, and Streptococcus pneumoniae during 2015 to 2018 in Turkey.

mSphere 2020 03 25;5(2). Epub 2020 Mar 25.

Department of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey.

The etiology of bacterial meningitis in Turkey changed after the implementation of conjugated vaccines against and type b (Hib) in the Turkish National Immunization Program (NIP). Administration of Hib vaccine and PCV-7 (7-valent pneumococcal conjugate vaccine) was implemented in NIP in 2006 and 2009, respectively. In 2011, PCV-7 was replaced with PCV-13. Read More

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http://dx.doi.org/10.1128/mSphere.00060-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096621PMC

Localized Hypermutation is the Major Driver of Meningococcal Genetic Variability during Persistent Asymptomatic Carriage.

mBio 2020 03 24;11(2). Epub 2020 Mar 24.

Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom

Host persistence of bacteria is facilitated by mutational and recombinatorial processes that counteract loss of genetic variation during transmission and selection from evolving host responses. Genetic variation was investigated during persistent asymptomatic carriage of Interrogation of whole-genome sequences for paired isolates from 25 carriers showed that mutations were infrequent, while horizontal gene transfer occurred in 16% of carriers. Examination of multiple isolates per time point enabled separation of sporadic and transient allelic variation from directional variation. Read More

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http://dx.doi.org/10.1128/mBio.03068-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157529PMC

Commensal Neisseria cinerea impairs Neisseria meningitidis microcolony development and reduces pathogen colonisation of epithelial cells.

PLoS Pathog 2020 03 24;16(3):e1008372. Epub 2020 Mar 24.

Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.

It is increasingly being recognised that the interplay between commensal and pathogenic bacteria can dictate the outcome of infection. Consequently, there is a need to understand how commensals interact with their human host and influence pathogen behaviour at epithelial surfaces. Neisseria meningitidis, a leading cause of sepsis and meningitis, exclusively colonises the human nasopharynx and shares this niche with several other Neisseria species, including the commensal Neisseria cinerea. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092958PMC

Characterization of invasive Neisseria meningitidis isolates recovered from children in Turkey during a period of increased serogroup B disease, 2013-2017.

Vaccine 2020 Apr 19;38(19):3545-3552. Epub 2020 Mar 19.

Meningococcal Reference Unit, Public Health England, Manchester, United Kingdom.

Diverse Neisseria meningitidis strains belonging to various serogroups and clonal complexes cause epidemic and endemic life-threatening disease worldwide. This study aimed to investigate the genetic diversity of recent invasive meningococci in Turkey with respect to multilocus sequence type (MLST) and also meningococcal serogroup B (MenB) vaccine antigens to enable assessment of potential MenB strain coverage using the genetic Meningococcal Antigen Typing System (gMATS). Fifty-four isolates, representing 37. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.03.024DOI Listing

Induced Fatal Waterhouse-Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure.

Brain Sci 2020 Mar 17;10(3). Epub 2020 Mar 17.

Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan.

-induced acute systemic meningococcal disease is an emergency and a fatal condition that has a high mortality rate. In patients with a fulminant infection, a maculopapular petechial eruption, purpura fulminans, or an ecchymotic lesion are worrisome signs reflecting disseminated intravascular coagulation (DIC) and hint at Waterhouse-Friderichsen syndrome (WFS). Here, we describe a rare case of a patient with a fulminant induced acute systemic meningococcal disease presenting with high-grade fever without meningitis symptoms. Read More

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http://dx.doi.org/10.3390/brainsci10030171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139770PMC

Meningococcal disease: A paradigm of type-IV pilus dependent pathogenesis.

Cell Microbiol 2020 Apr;22(4):e13185

Inserm, U1016, Institut Cochin, Paris, France.

Neisseria meningitidis (meningococcus) is a Gram-negative bacterium responsible for two devastating forms of invasive diseases: purpura fulminans and meningitis. Interaction with both peripheral and cerebral microvascular endothelial cells is at the heart of meningococcal pathogenesis. During the last two decades, an essential role for meningococcal type IV pili in vascular colonisation and disease progression has been unravelled. Read More

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http://dx.doi.org/10.1111/cmi.13185DOI Listing

An assessment of the use of Hepatitis B Virus core protein virus-like particles to display heterologous antigens from Neisseria meningitidis.

Vaccine 2020 Apr 13;38(16):3201-3209. Epub 2020 Mar 13.

Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PL, UK. Electronic address:

Neisseria meningitidis is the causative agent of meningococcal meningitis and sepsis and remains a significant public health problem in many countries. Efforts to develop a comprehensive vaccine against serogroup B meningococci have focused on the use of surface-exposed outer membrane proteins. Here we report the use of virus-like particles derived from the core protein of Hepatitis B Virus, HBc, to incorporate antigen domains derived from Factor H binding protein (FHbp) and the adhesin NadA. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113836PMC

Peripheral Gangrene and Extremity Amputations - Painful Preventable Sequelae of Meningococcal Septicaemia: Case Series Reports.

West Afr J Med 2020 Apr-Jun;37(2):189-196

Department of Paediatrics Ahmadu Bello University Teaching Hospital, Zaria, Kaduna State,Nigeria.

Extremity gangrene is a fairly common pathology, which complicates systemic vascular and endocrine diseases. Most often, it is encountered in diseases like uncontrolled Diabetes Mellitus, presenting as diabetic foot gangrene, severe peripheral arteriosclerosis with gangrene of the extremity complicating severe uncontrolled systemic hypertension and meningococcal septicaemia with peripheral gangrene. It also occurs in some cases of snake bite as well as frost bite (in regions with extreme cold weather conditions). Read More

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Understanding immunogenicity assessments for meningococcal serogroup B vaccines.

Postgrad Med 2020 Mar 3;132(2):184-191. Epub 2020 Mar 3.

Vaccine Medical Development, Scientific & Clinical Affairs, Pfizer Inc, Collegeville, PA, USA.

Invasive meningococcal disease (IMD) is a potentially devastating infection associated with high mortality and long-term sequelae; however, vaccines are available to protect against the five common disease-causing serogroups (A, B, C, W, and Y). Because traditional field efficacy clinical trials were not feasible due to low IMD incidence that necessitates a very large number of participants, serum bactericidal antibody (SBA) assays using rabbit (rSBA) or human (hSBA) complement were established as surrogates of meningococcal vaccine efficacy and are now routinely used to support vaccine licensure. Specifically, rSBA assays have been used to evaluate responses to meningococcal capsular polysaccharide-protein conjugate vaccines against serogroups A, C, W, and Y; the accepted correlate of protection for rSBA assays is a titer ≥1:8. Read More

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http://dx.doi.org/10.1080/00325481.2019.1696582DOI Listing

Cerebrospinal meningitis: a global disease with regional variability?

Authors:
Jason L Siegel

Neurol Neurochir Pol 2020 ;54(1):6-7

Department of Neurology, Department of Critical Care Medicine, Department of Neurosurgery, Mayo Clinic, Jacksonville, Florida, USA.

Introduction: In this edition, Szymanski et al. present the results of their retrospective study of the clinical differences between patients with meningococcal meningitis and pneumococcal cerebrospinal meningitis at the Regional Specialistic Hospital in Wroclaw, Poland.

Clinical Reflections: The authors found that compared to patients with N. Read More

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http://dx.doi.org/10.5603/PJNNS.a2020.0014DOI Listing

Randomized Trial of 2 Schedules of Meningococcal B Vaccine in Adolescents and Young Adults, Canada.

Emerg Infect Dis 2020 Mar;26(3):454-462

Emergency vaccination programs often are needed to control outbreaks of meningococcal disease caused by Neisseria meningitidis serogroup B (MenB) on college campuses. Such campaigns expend multiple campus and public health resources. We conducted a randomized, controlled, multicenter, observer-blinded trial comparing immunogenicity and tolerability of an accelerated vaccine schedule of 0 and 21 days to a longer interval of 0 and 60 days for 4-component MenB vaccine (MenB-4C) in students 17-25 years of age. Read More

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http://dx.doi.org/10.3201/eid2603.190160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045834PMC

Health workers' perceptions and challenges in implementing meningococcal serogroup a conjugate vaccine in the routine childhood immunization schedule in Burkina Faso.

BMC Public Health 2020 Feb 19;20(1):254. Epub 2020 Feb 19.

UNICEF, New York, NY, 10017, USA.

Background: Meningococcal serogroup A conjugate vaccine (MACV) was introduced in 2017 into the routine childhood immunization schedule (at 15-18 months of age) in Burkina Faso to help reduce meningococcal meningitis burden. MACV was scheduled to be co-administered with the second dose of measles-containing vaccine (MCV2), a vaccine already in the national schedule. One year following the introduction of MACV, an assessment was conducted to qualitatively examine health workers' perceptions of MACV introduction, identify barriers to uptake, and explore opportunities to improve coverage. Read More

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http://dx.doi.org/10.1186/s12889-020-8347-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031928PMC
February 2020

Human genetics of meningococcal infections.

Hum Genet 2020 Jun 17;139(6-7):961-980. Epub 2020 Feb 17.

Department of Paediatric Infectious Disease, Faculty of Medicine, Imperial College London, Norfolk Place, London, W2 1PG, UK.

Neisseria meningitidis is a leading cause of bacterial septicaemia and meningitis worldwide. Meningococcal disease is rare but can be life threatening with a tendency to affect children. Many studies have investigated the role of human genetics in predisposition to N. Read More

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http://dx.doi.org/10.1007/s00439-020-02128-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272491PMC

Complement interactions with the pathogenic Neisseriae: clinical features, deficiency states, and evasion mechanisms.

FEBS Lett 2020 Feb 14. Epub 2020 Feb 14.

Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA.

Neisseria gonorrhoeae causes the sexually transmitted infection gonorrhea, while Neisseria meningitidis is an important cause of bacterial meningitis and sepsis. Complement is a central arm of innate immune defenses and plays an important role in combating Neisserial infections. Persons with congenital and acquired defects in complement are at a significantly higher risk for invasive Neisserial infections such as invasive meningococcal disease and disseminated gonococcal infection compared to the general population. Read More

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http://dx.doi.org/10.1002/1873-3468.13760DOI Listing
February 2020

Diversity of meningococci associated with invasive meningococcal disease in the Republic of Ireland over a 19 year period, 1996-2015.

PLoS One 2020 13;15(2):e0228629. Epub 2020 Feb 13.

Irish Meningitis and Sepsis Reference Laboratory, Children's Health Ireland, Dublin, Ireland.

This study examined the capsular phenotype and genotype of invasive meningococcal disease (IMD)-associated Neisseria meningitidis recovered in the Republic of Ireland (RoI) between 1996 and 2015. This time period encompasses both pre- (when IMD was hyperendemic in the RoI) and post- meningococcal serogroup C conjugate (MCC) vaccine introduction. In total, 1327 isolates representing over one-third of all laboratory-confirmed cases of IMD diagnosed each epidemiological year (EY), were characterised. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228629PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018037PMC

Clinical manifestations of invasive meningococcal disease in Victoria with the emergence of serogroup W and serogroup Y Neisseria meningitidis.

Intern Med J 2020 Feb 11. Epub 2020 Feb 11.

Infectious Diseases Physician, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.

Background: Historically, Australian cases of invasive meningococcal disease (IMD) have been most frequently caused by Neisseria meningitidis serogroup-B, but recently an increase in cases due to serogroup-W (MenW) and serogroup-Y (MenY) has occurred.

Aims: To determine whether clinical manifestations of IMD have changed due to increased incidence of MenW and MenY.

Methods: We performed a retrospective review of IMD cases notified to the Department of Health and Human Services in Victoria, Australia. Read More

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http://dx.doi.org/10.1111/imj.14771DOI Listing
February 2020

with H552Y substitution on gene shows attenuated behavior : report of a rifampicin-resistant case following chemoprophylaxis.

J Chemother 2020 Apr 10;32(2):98-102. Epub 2020 Feb 10.

Department of Health Sciences, University of Florence and Meyer Children's University Hospital, Florence, Italy.

We present the first Italian reported case of an invasive meningococcal disease with rifampicin-resistance (Rif-R)secondary to chemoprophylaxis. The case is entered in a cluster of two IMDs registered in Tuscany, Italy, in November 2019 caused by two non-differentiable group-C belonging to ST-11 clonal-complex. The contact case, differently from the index, harbored H552Y mutation on gene which is known to confer Rif-R putting a high-cost fee on bacterial fitness. Read More

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http://dx.doi.org/10.1080/1120009X.2020.1723967DOI Listing

Meningococcal Disease-Associated Prophage-Like Elements Are Present in Neisseria gonorrhoeae and Some Commensal Neisseria Species.

Genome Biol Evol 2020 02;12(2):3938-3950

The Marshall Centre for Infectious Diseases Research and Training, The University of Western Australia, Crawley, Australia.

Neisseria spp. possess four genogroups of filamentous prophages, termed Nf1 to 4. A filamentous bacteriophage from the Nf1 genogroup termed meningococcal disease-associated phage (MDA φ) is associated with clonal complexes of Neisseria meningitidis that cause invasive meningococcal disease. Read More

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http://dx.doi.org/10.1093/gbe/evaa023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058167PMC
February 2020

Surveillance of penicillin resistance of strains from invasive infections between 2013 and 2018 in Turkey.

J Chemother 2020 Jul 7;32(4):213-216. Epub 2020 Feb 7.

Department of Medical Microbiology, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey.

() is regarded as the leading cause of bacterial meningitis in many regions of the world. The empiric antimicrobial treatment is mainly based on antimicrobial resistance and patient characteristics. We aimed to analyze susceptibility patterns of N. Read More

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http://dx.doi.org/10.1080/1120009X.2020.1721176DOI Listing