72,576 results match your criteria Meningitis Haemophilus


Computed tomography thorax abnormalities in immunocompetent patients with tuberculous meningitis: An observational study.

J Neurol Sci 2018 Dec 7;397:11-15. Epub 2018 Dec 7.

Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.

Objective: Computed tomography (CT) of the thorax is the imaging modality of choice to detect or demonstrate lesions suggestive of active pulmonary tuberculosis. We aimed to evaluate the imaging abnormalities detected on CT of the thorax in patients with tuberculous meningitis (TBM).

Methods: In this prospective study, we enrolled consecutive newly-diagnosed patients with TBM. Read More

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December 2018

Recent Progress on Functional Genomics Research of Enterovirus 71.

Virol Sin 2018 Dec 14. Epub 2018 Dec 14.

Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

Enterovirus 71 (EV71) is one of the main pathogens that causes hand-foot-and-mouth disease (HFMD). HFMD caused by EV71 infection is mostly self-limited; however, some infections can cause severe neurological diseases, such as aseptic meningitis, brain stem encephalitis, and even death. There are still no effective clinical drugs used for the prevention and treatment of HFMD. Read More

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December 2018
1 Read

Distribution of Late-Onset Neonatal Sepsis Pathogens Differs in Inpatient and Outpatient Settings.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, New York University School of Medicine, New York, New York.

Objective:  We sought to examine pathogen distribution and clinical presentation of late-onset sepsis (LOS) at an urban tertiary care center.

Study Design:  We performed a retrospective review of all culture-confirmed cases of LOS presenting to our institution from 2013 to 2017. Medical records were evaluated for demographic information, sepsis risk factors, encounter location, and clinical outcome. Read More

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December 2018
1 Read

Occurrence of virulence factors in Cronobacter sakazakii and Cronobacter malonaticus originated from clinical samples.

Microb Pathog 2018 Dec 11. Epub 2018 Dec 11.

Microbiology Department, Faculty of Biomedical Sciences, Sabha University, Sabha, Libya.

Background: Cronobacter spp. are Gram-negative, facultative-anaerobic, non-spore forming, enteric coliform bacteria, which belongs to the Enterobacteriaceae family. Cronobacter spp. Read More

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December 2018

Detection of Pediatric Bacterial Meningitis Pathogens from Cerebrospinal Fluid by Next-Generation Sequencing Technology.

J Infect 2018 Dec 11. Epub 2018 Dec 11.

Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China. Electronic address:

Objectives: Bacterial meningitis remains one of the major challenges in infectious diseases, leading to sequel in many cases. A prompt diagnosis of the causative microorganism is critical to significantly improve outcome of bacterial meningitis. Although various targeted tests for cerebrospinal fluid (CSF) samples are available, it is a big problem for the identification of etiology of bacterial meningitis. Read More

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December 2018

Bacteremia and meningitis caused by a novel clone of Neisseria meningitidis serogroup B.

Pediatr Int 2018 Dec 11. Epub 2018 Dec 11.

Division of Pediatrics, Uji-Tokushukai Medical Center, Uji, Japan.

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December 2018

Atypical type of familial Mediterranean fever: An underdiagnosed cause of chronic aseptic meningitis.

Neurol Clin Neurosci 2018 Nov 24;6(6):191-193. Epub 2018 Sep 24.

Department of Neurology Shin-yurigaoka General Hospital Kanagawa Japan.

We report an atypical case of familial Mediterranean fever (FMF) concomitant with chronic aseptic meningitis. The patient experienced fever, abdominal and back pain because of serositis, and headache because of aseptic meningitis for 4 weeks. Blood examinations revealed increased white blood cells and serum amyloid A level. Read More

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November 2018
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Cryptococcal meningitis in a multiple sclerosis patient treated with Fingolimod: a case report and review of imaging findings.

Clin Imaging 2018 Nov 14;54:53-56. Epub 2018 Nov 14.

Department of Radiology, Baylor College of Medicine, One Baylor Plaza, BCM 360, Houston, TX 77030, United States.

Fingolimod is an oral medication approved by the Food and Drug Administration in 2009 for the treatment of relapsing remitting multiple sclerosis (RRMS). Initial clinical trials did not show a significantly increased rate of serious infections with fingolimod therapy. However, a mildly increased risk of less serious infections, such as varicella zoster virus and herpes simplex virus, was reported. Read More

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November 2018

Epidemiology of lumbar punctures in hospitalized patients in the United States.

PLoS One 2018 13;13(12):e0208622. Epub 2018 Dec 13.

Department of Emergency Medicine, University of Alabama School of Medicine, Birmingham, Alabama, United States of America.

Objectives: Lumbar puncture (LP) is an important technique for assessing and treating neurological symptoms. The objective of this study was to describe the characteristics of diagnostic lumbar punctures performed on hospitalized patients in the United States.

Methods: We analyzed data from the 2010 National Inpatient Sample (NIS) and the National Emergency Department Survey (NEDS). Read More

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December 2018
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The Streptococcos suis sortases SrtB and SrtF are essential for disease in pigs.

Microbiology 2018 Dec 13. Epub 2018 Dec 13.

1​Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

The porcine pathogen Streptococcus suis colonizes the upper respiratory tracts of pigs, potentially causing septicaemia, meningitis and death, thus placing a severe burden on the agricultural industry worldwide. It is also a zoonotic pathogen that is known to cause systemic infections and meningitis in humans. Understanding how S. Read More

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December 2018

The Effect of National Pneumococcal Vaccination Program on Incidence of Postmeningitis Sensorineural Hearing Loss and Current Treatment Modalities.

J Int Adv Otol 2018 Dec 12. Epub 2018 Dec 12.

Department of Otolaryngology, Hacettepe University School of Medicine, Ankara, Turkey.

Objectives: The aim of the present study was to investigate the effect of the national pneumococcal vaccination program on postmeningitis sensorineural hearing loss (SNHL).

Materials And Methods: Overall, 2751 patients (2615 cochlear implantation and 136 auditory brainstem implantation) who underwent cochlear implantation (CI) and auditory brainstem implantation (ABI) at a tertiary referral hospital otolaryngology clinic were retrospectively analyzed. One hundred sixteen patients with a history of meningitis were included in the study. Read More

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December 2018

Environmental, economic and socio-cultural risk factors of recurrent seasonal epidemics of cerebrospinal meningitis in Kebbi state, northwestern Nigeria: a qualitative approach.

BMC Public Health 2018 Dec 13;18(Suppl 4):1318. Epub 2018 Dec 13.

World Health Organisation, Country Representative Office, Abuja, Nigeria.

Background: Kebbi State remains the epicentre of the seasonal epidemic meningitis in northwestern Nigeria despite interventions. In this setting, no previous study has been conducted to understand the risk factors of the recurrent meningitis epidemics using qualitative approach. Consequently, this study intends to explore and better understand the environmental, economic and socio-cultural factors of recurrent seasonal epidemic meninigitis using a qualitative approach. Read More

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December 2018

High dose fluconazole in salvage therapy for HIV-uninfected cryptococcal meningitis.

BMC Infect Dis 2018 Dec 12;18(1):643. Epub 2018 Dec 12.

Department of Infectious Diseases, Huashan Hospital, Fudan University, 12 Central Urumqi Road, Shanghai, China.

Background: The 2010 Infectious Diseases Society of America (IDSA) guidelines for management of cryptococcal diseases recommend high dose fluconazole (≥ 800 mg/day), either alone or with other antifungal drugs, as alternative anticryptococcal choices. But evidence for its use in the treatment of HIV-uninfected cryptococcal meningitis (CM) remains sparse.

Methods: A retrospective analysis of HIV-uninfected CM patients who received fluconazole 800 mg/day for salvage therapy from January 2011 to December 2016 at Huashan Hospital, Shanghai, China was performed. Read More

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December 2018

The Incidence of Meningitis in Patients with Traumatic Brain Injury Undergoing External Ventricular Drain Placement: A Nationwide Inpatient Sample Analysis.

Neurocrit Care 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurosurgery, State University of New York Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.

Background/objective: Infection is the most common complication of external ventricular drain (EVD) placement. National trends in the annual incidence of meningitis among patients with traumatic brain injury (TBI) who have undergone EVD placement have not been reported.

Methods: The Nationwide Inpatient Sample was used to select adults with a primary diagnosis of TBI who underwent EVD placement between 2002 and 2011. Read More

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December 2018

Household transmission of seasonal influenza from HIV-infected and -uninfected individuals in South Africa, 2013-2014.

J Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.

Background: Differential transmission from HIV-infected compared to HIV-uninfected individuals may impact influenza burden. We estimated the household secondary infection risk (SIR) and serial interval (SI) for influenza transmission from HIV-infected and HIV-uninfected index cases and identified associated factors.

Methods: Index cases were the first symptomatic person in a household with influenza-like illness, testing influenza positive on real-time reverse transcription polymerase chain reaction (rRT-PCR). Read More

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December 2018
1 Read

Stapes footplate defect as a source of CSF leak and otogenic meningitis in a patient with a cochlear implant.

Ear Nose Throat J 2018 Dec;97(12):E31-E32

Department of Otolaryngology, The Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.

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December 2018

Importance of cerebrospinal fluid investigation during dengue infection in Brazilian Amazonia Region.

Mem Inst Oswaldo Cruz 2018 Dec 10;114:e180450. Epub 2018 Dec 10.

Universidade Federal do Estado do Rio de Janeiro/Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

BACKGROUND Amazon, the largest tropical forest of the world, has suffered from dengue outbreaks since 1998. Cerebrospinal fluid (CSF) of patients, from Amazonas state, suspected of central nervous system (CNS) viral infection was studied using molecular and immunological methods. OBJECTIVE To evaluate the importance of CSF investigation in patients with acute dengue virus (DENV) infection of CNS. Read More

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December 2018
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Comparison and Correlation of Magnetic Resonance Imaging and Clinical Severity in Nonhuman Immunodeficiency Virus Patients with Cryptococcal Infection of Central Nervous System.

Chin Med J (Engl) 2018 Dec;131(24):2930-2937

Department of Radiology, Beijing Youan Hospital Affiliated to Capital Medical University, Beijing 100069, China.

Background: The incidence of cryptococcal meningitis among immunocompetent patients increases, especially in China and imaging plays an important role. The current study was to find the correlation between magnetic resonance imaging (MRI) manifestation and clinical severity in nonhuman immunodeficiency virus patients with cryptococcal infection of central nervous system (CNS).

Methods: A total of 65 patients with CNS cryptococcal infection from August 2014 to October 2016 were retrospectively included in this study. Read More

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December 2018

Biobanking of Cerebrospinal Fluid.

Methods Mol Biol 2019 ;1897:107-114

Division of Neuropathology, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Cerebrospinal fluid (CSF) is a physiologically essential fluid produced by the brain that is involved in protecting the brain and in the exchange of nutrients and waste products. CSF has long been utilized to confirm clinical suspicion of various infectious and inflammatory disorders, such as meningitis and multiple sclerosis. However, there has been increasing interest in collecting CSF in order to study the clinical significance of additional biomarkers. Read More

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January 2019

Cost-Effectiveness of the Pneumococcal Conjugate Vaccine (10- or 13-Valent) Versus No Vaccination for a National Immunization Program in Tunisia or Algeria.

Infect Dis Ther 2018 Dec 11. Epub 2018 Dec 11.

Pfizer, Collegeville, PA, USA.

Introduction: To evaluate the expected impact of the Algeria national immunization program (NIP) and potential impact for a Tunisia NIP, this study assessed the public health and economic value of vaccination, through a cost-effectiveness analysis, for a PCV13 or PCV10 NIP, compared with no vaccination.

Methods: A decision-analytic model was programmed in Microsoft Excel™ and adapted to evaluate the clinical and economic outcomes of PCV vaccination. Assuming a steady state, the model estimated invasive pneumococcal disease (IPD; bacteremia and meningitis), all-cause pneumonia (inpatient and outpatient), and all-cause otitis media cases as well as the associated costs from a payer perspective. Read More

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December 2018

The Role of Pneumococcal Virulence Factors in Ocular Infectious Diseases.

Interdiscip Perspect Infect Dis 2018 13;2018:2525173. Epub 2018 Nov 13.

Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, MS 39216, USA.

is a gram-positive, facultatively anaerobic pathogen that can cause severe infections such as pneumonia, meningitis, septicemia, and middle ear infections. It is also one of the top pathogens contributing to bacterial keratitis and conjunctivitis. Though two pneumococcal vaccines exist for the prevention of nonocular diseases, they do little to fully prevent ocular infections. Read More

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November 2018
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Neuroinvasive Infection Triggers IFN-Activation of Microglia and Upregulates Microglial miR-155.

Front Immunol 2018 27;9:2751. Epub 2018 Nov 27.

Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.

MicroRNA (miR) miR-155 modulates microglial activation and polarization, but its role in activation of microglia during bacterial brain infection is unclear. We studied miR-155 expression in brains of C57BL/6 (B6.WT) mice infected i. Read More

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November 2018
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Clinical characteristics and antimicrobial resistance of pneumococcal isolates of pediatric invasive pneumococcal disease in China.

Infect Drug Resist 2018 26;11:2461-2469. Epub 2018 Nov 26.

Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Purpose: causes serious infections globally, including invasive pneumococcal disease (IPD). We analyze clinical features of pediatric IPD cases identified in China and antibiotic susceptibility of isolated pneumococcal strains.

Methods: Confirmed pediatric IPD patients were prospectively recruited to the study. Read More

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November 2018

The Meningococcal Cysteine Transport System Plays a Crucial Role in Survival in Human Brain Microvascular Endothelial Cells.

MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.

RIKEN Structural Biology Laboratory, Yokohama, Japan.

While typically exists in an asymptomatic nasopharyngeal carriage state, it may cause potentially lethal diseases in humans, such as septicemia or meningitis, by invading deeper sites in the body. Since the nutrient compositions of human cells are not always conducive to meningococci, needs to exploit nutrients from host environments. In the present study, the utilization of cysteine by the meningococcal cysteine transport system (CTS) was analyzed for the pathogenesis of meningococcal infections. Read More

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December 2018
4 Reads

Otopathology in Angiosarcoma of the Temporal Bone.

Laryngoscope 2018 Dec 11. Epub 2018 Dec 11.

Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts.

Objectives/hypothesis: Investigate the otopathology of angiosarcoma of the temporal bone, which has not been previously described in the literature.

Study Design: Postmortem evaluation and literature review.

Methods: Postmortem histological evaluation of the temporal bones and review of the literature for the treatment and prognosis of this rare disease were performed. Read More

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December 2018
4 Reads

Overview of antibody-mediated immunity to S. pneumoniae: pneumococcal infections, pneumococcal immunity assessment, and recommendations for IG product evaluation.

Transfusion 2018 Dec;58 Suppl 3:3106-3113

Regional Immunology Service, The Royal Hospitals, Belfast Health & Social Care Trust and Queen's University Belfast, Belfast, UK.

Streptococcus pneumoniae (S. pneumoniae) strains colonize the nasopharynx and can cause mucosal infections in the upper airway and middle ear, pneumonias, and invasive infections like bacteremia, sepsis, and meningitis. Over 90 serotypes, defined by the structure of their capsular polysaccharides, are known. Read More

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December 2018
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Lyme neuroborreliosis- clinical outcomes, controversy, pathogenesis, and polymicrobial infections.

Ann Neurol 2018 Dec 10. Epub 2018 Dec 10.

Department of Molecular Genetics and Microbiology and Pathology, Stony Brook University School of Medicine, Stony Brook, NY, USA.

Lyme Borreliosis is the object of numerous misconceptions. In this review, we revisit the fundamental manifestations of neuroborreliosis (meningitis and cranial and radiculoneuritis) as these have withstood the test of time. We also discuss other manifestations that are less frequent. Read More

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December 2018

[Neonatal viral meningitis. The importance of the polymerase chain reaction in their diagnosis].

Rev Neurol 2018 Dec;67(12):484-490

Hospital General Universitario de Albacete, 02006 Albacete, Espana.

Introduction: The different types of viral meningitis constitute a condition that is relatively frequent in newborn infants, although in many cases they are underdiagnosed due to the absence of pleocytosis in the cerebrospinal fluid (CSF).

Aims: To describe the clinical features and laboratory findings of newborn infants with viral meningitis and to highlight the importance of the polymerase chain reaction (PCR) in the CSF to diagnose this condition.

Patients And Methods: A retrospective review of the medical records of newborn infants hospitalised in the neonatology section who had been diagnosed with viral meningitis between May 2014 and May 2017. Read More

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December 2018

Application of the Bacterial Meningitis Score for Infants Aged 0 to 60 Days.

J Pediatric Infect Dis Soc 2018 Dec 10. Epub 2018 Dec 10.

Division of Emergency Medicine, Boston Children's Hospital, Harvard Medical School, Massachusetts.

In 4292 infants aged ≤60 days with cerebrospinal fluid (CSF) pleocytosis, the bacterial meningitis score had excellent sensitivity (121 of 121 [100.0%] [95% confidence interval, 96.5%-100. Read More

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December 2018

Cerebrospinal fluid pharmacokinetics of ceftaroline in neurosurgical patients with an external ventricular drain.

J Antimicrob Chemother 2018 Dec 6. Epub 2018 Dec 6.

Département d'Infectiologie, CHU and INSERM CIC1432, Université de Bourgogne, Dijon, France.

Background: Owing to its antibacterial properties, ceftaroline could be attractive for prevention or treatment of bacterial post-neurosurgical meningitis/ventriculitis. However, few data are available concerning its meningeal concentrations.

Objectives: To investigate ceftaroline CSF pharmacokinetics in ICU patients with an external ventricular drain (EVD). Read More

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December 2018

[Cryptococcosis in Hospital Carlos Van Buren, Valparaiso: a clinical serie].

Rev Chilena Infectol 2018 Aug;35(4):420-423

Universidad de Valparaíso, Valparaíso, Chile.

Background: Cryptococcosis is a severe opportunistic mycotic infection, caused mainly by Cryptococcus neoformans. It can present as meningitis, pneumonia or cryptococcemia.

Aim: To characterize patients with Cryptococcus infection between January 1°, 2013 and June 30, 2016, in Hospital Carlos van Buren, Valparaíso, Chile. Read More

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[Post-surgical ventriculitis due to extensively resistant Pseudomonas aeruginosa treated with intrathecal colistin. Pediatric case report and literature review].

Rev Chilena Infectol 2018 ;35(3):321-325

Universidad CES, Medellín, Colombia.

Use of Intrathecal colistin has increased in recent years and has become an alternative for the management of infections of the central nervous system caused by multidrug resistant (MDR) bacteria. Evidence of therapeutic success and safety profile is increasing, particularly in MDR Acinetobacter baumanii infections in adults. Conversely, evidence in children is limited. Read More

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January 2018

[Notes for the history about the Doctor Lucio Cordova Infectious Diseases Hospital].

Authors:
Laval R Enrique

Rev Chilena Infectol 2018 ;35(3):314-316

Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile.

The author presents a historical review about the creation of Doctor Lucio Cordova Infectious Diseases Hospital. Lucio Cordova MD, Counselor of the Charity Board in 1938, promoted a model pavilion for the hospitalization of patients with communicable diseases. An outbreak of meningococcal meningitis, between 1941 and 1942, hurried the construction of the Infectious Disease Pavilion, which was finished in 1949. Read More

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January 2018

Draft Genome Sequences for a Diverse Set of Seven and Species.

Microbiol Resour Announc 2018 Oct 25;7(16). Epub 2018 Oct 25.

Minnesota Department of Health Public Health Laboratory, St. Paul, Minnesota, USA.

is a complex genus that includes commensal and pathogenic species that pose a public health threat to humans. While the pathogenic species have been studied extensively, many commensals have limited genomic information available. Here, we present 24 draft genomes for a diverse set of 7 and species. Read More

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October 2018

Complete Genome Sequence of the Multidrug-Resistant Neonatal Meningitis Escherichia coli Serotype O75:H5:K1 Strain mcjchv-1 (NMEC-O75).

Microbiol Resour Announc 2018 Sep 13;7(10). Epub 2018 Sep 13.

Department of Population Health, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA.

Neonatal meningitis Escherichia coli (NMEC) is the second leading cause of neonatal bacterial meningitis worldwide. We report the genome sequence of the multidrug-resistant NMEC serotype O75:H5:K1 strain mcjchv-1, which resulted in an infant's death. The O75 serogroup is rare among NMEC isolates; therefore, this strain is considered an emergent pathogen. Read More

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September 2018

Methicillin-resistant Staphylococcus aureus Meningitis as a Complication of Facial Nerve Decompression for Vertebrobasilar Dolichoectasia.

Cureus 2018 Oct 1;10(10):e3392. Epub 2018 Oct 1.

Radiology, VA Medical Center, Riviera Beach, USA.

We present a case of a 55-year-old lady with intermittent twitching of the left side of her face, involving her left eyelid and the angle of the mouth, ongoing for two years. She failed multiple trials of botulinum toxin injections as well as oral anti-spasmodic medications. The patient was diagnosed with an ectatic left vertebral artery, causing a compression of cranial nerve VII on the same side on magnetic resonance imaging (MRI) of the brain. Read More

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October 2018
8 Reads

Central and Peripheral Nervous System Involvement in a Patient with Scrub Infection.

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):318-321

Department of Critical Care Medicine, SPS Hospitals, Ludhiana, Punjab, India.

Scrub infection is an important differential of undifferentiated febrile illness in the subtropical and tropical countries. Neurological complications of scrub infection have a varied spectrum of presentation involving both the central nervous system, among which meningitis and meningoencephalitis are the most common presentations. The peripheral nervous system manifestations include Guillain-Barre syndrome (GBS) is not commonly reported. Read More

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December 2018

Fluconazole induces ROS in Cryptococcus neoformans and contributes to DNA damage in vitro.

PLoS One 2018 7;13(12):e0208471. Epub 2018 Dec 7.

Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America.

Pathogenic basidiomycetous yeast, Cryptococcus neoformans, causes fatal meningitis in immunocompromised individuals. Fluconazole (FLC) is a fungistatic drug commonly administered to treat cryptococcosis. Unfortunately, FLC-resistant strains characterized by various degree of chromosomal instability were isolated from clinical patients. Read More

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December 2018

Genetic diversity of the enteroviruses detected from cerebrospinal fluid (CSF) samples of patients with suspected aseptic meningitis in northern West Bank, Palestine in 2017.

PLoS One 2018 10;13(12):e0202243. Epub 2018 Dec 10.

Rafeedia Medical Laboratory Hospital, Palestinian Ministry of Health, Nablus, Palestine.

Background: Human enterovirus genus showed a wide range of genetic diversity.

Objectives: To investigate the genetic diversity of the enteroviruses isolated in 2017 in northern West Bank, Palestine.

Study Design: 249 CSF samples from aseptic meningitis cases were investigated for HEV using two RT-PCR protocols targeting the 5' NCR and the VP1 region of the HEV genome. Read More

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December 2018

Acyclovir Neurotoxicity in a Peritoneal Dialysis Patient: Report of a Case and Review of the Pharmacokinetics of Acyclovir.

Am J Case Rep 2018 Dec 9;19:1459-1462. Epub 2018 Dec 9.

Pharmacy Section, Jerry L Pettis Veterans Memorial Medical Center, Loma Linda, CA, USA.

BACKGROUND The elderly population in the United States and the world is rapidly increasing. With aging, immunity and kidney function decrease, thus predisposing people to viral illnesses for which there is no effective prophylaxis. Herpes zoster afflicts the elderly and other immunocompromised patients, like those with end-stage renal disease, transplant recipients, and cancer patients, causing significant morbidity and sometimes mortality. Read More

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December 2018

Utility of OTOPLAN Reconstructed Images for Surgical Planning of Cochlear Implantation in a Case of Post-meningitis Ossification.

Otol Neurotol 2019 Jan;40(1):e60-e61

Department of Neuroscience, University of Padova, Audiology Unit at Treviso Hospital, Treviso, Italy.

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January 2019

Epidemiology of Meningitis and Encephalitis in Infants and Children in the United States, 2011-2014.

Pediatr Infect Dis J 2019 Jan;38(1):37-41

bioMérieux, Durham, NC.

Background: Large epidemiologic studies evaluating the etiologies, management decisions and outcomes of infants and children with meningitis and encephalitis in the United States are lacking.

Methods: Children 0-17 years of age with meningitis or encephalitis as assessed by International Classification of Diseases, Ninth Revision, codes available in the Premier Healthcare Database during 2011-2014 were analyzed.

Results: Six thousand six hundred sixty-five patients with meningitis or encephalitis were identified; 3030 (45. Read More

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January 2019

Medical Referral Patterns and Etiologies for Children With Mild-to-Severe Hearing Loss.

Ear Hear 2018 Dec 6. Epub 2018 Dec 6.

Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.

Objectives: To (1) identify the etiologies and risk factors of the patient cohort and determine the degree to which they reflected the incidence for children with hearing loss and (2) quantify practice management patterns in three catchment areas of the United States with available centers of excellence in pediatric hearing loss.

Design: Medical information for 307 children with bilateral, mild-to-severe hearing loss was examined retrospectively. Children were participants in the Outcomes of Children with Hearing Loss (OCHL) study, a 5-year longitudinal study that recruited subjects at three different sites. Read More

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December 2018

Enterovirus and parechovirus meningitis in infants younger than 90 days old in the UK and Republic of Ireland: a British Paediatric Surveillance Unit study.

Arch Dis Child 2018 Dec 8. Epub 2018 Dec 8.

Paediatric Infectious Diseases Research Group, St George's University of London, London, UK.

Objectives: This study aimed to prospectively collect detailed clinical information for all enterovirus (EV) and human parechovirus (HPeV) meningitis cases in infants aged <90 days in the UK and Ireland.

Participants, Design And Setting: Prospective, active national surveillance during July 2014 to July 2015 through the British Paediatric Surveillance Unit. Reporting paediatricians completed questionnaires requesting information on clinical presentation, investigations, management and outcomes at hospital discharge and after 12 months. Read More

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December 2018

Outcome of Ventriculo-peritoneal Shunt Surgery in Human Immunodeficiency Virus - Positive Patients on Combination Antiretroviral Therapy with Tuberculosis Meningitis and Hydrocephalus.

World Neurosurg 2018 Dec 6. Epub 2018 Dec 6.

Background: In 2000 we advised against insertion of a ventriculo-peritoneal shunt (VPS) in Human Immunodeficiency Virus (HIV) positive patients with tuberculous meningitis (TBM) complicated by hydrocephalus. However, this was in the era when combination antiretroviral therapy (ART) was not freely available in South Africa. In this subsequent preliminary report, we describe the outcome of ventriculo-peritoneal (VP) shunting in patients with TBM and hydrocephalus that are HIV positive and receiving ART. Read More

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December 2018

Paradoxical Reaction in HIV-negative TBM Patients with Spinal Involvement.

Int J Infect Dis 2018 Dec 4. Epub 2018 Dec 4.

Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Objective: The aim of this study was to investigate the occurrence of paradoxical reaction (PR) in HIV-negative tuberculous meningitis (TBM) patients with spinal involvement, as well as its possible risk factors.

Methods: Fifty TBM patients with spinal involvement were retrospectively studied and divided into a PR group and a Non-PR group according to the presence of PR. Their demographic, clinical, radiology and laboratory data, and status at follow-up were collected and compared. Read More

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December 2018
2.330 Impact Factor

Enhanced Arboviral Surveillance to Increase Detection of Jamestown Canyon Virus Infections, Wisconsin, 2011-2016.

Am J Trop Med Hyg 2018 Dec 10. Epub 2018 Dec 10.

Division of Public Health, Wisconsin Department of Health Services, Madison, Wisconsin.

Jamestown Canyon virus (JCV), a mosquito-borne (within the California serogroup), can cause severe neuroinvasive disease. According to national data during 2000-2013, 42% of the 31 documented JCV disease cases in the United States were detected in residents from Wisconsin. The Wisconsin Division of Public Health enhanced JCV surveillance by implementing routine use of JCV-specific immunoglobulin M (IgM) antibody testing followed by confirmatory JCV-specific plaque reduction neutralization testing on all patients with suspected cases of arboviral infection who had tests positive for arboviral immunoglobin at commercial laboratories. Read More

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December 2018

Serotype distribution, antibiotic resistance pattern and multilocus sequence types of invasive Streptococcus pneumoniae isolates in two tertiary pediatric hospitals in Beijing prior to PCV13 availability.

Expert Rev Vaccines 2018 Dec 10. Epub 2018 Dec 10.

a Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases , National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health , Beijing , China.

Background: Invasive pneumococcal disease (IPD) is a serious threat to children worldwide. This study reported the serotype distribution, antibiotic resistance pattern and multilocus sequence types of 111 IPD strains isolated from children less than 14 years old in two tertiary pediatric centers in Beijing during years 2012-2017. Methods Serotypes were determined using Quellung reaction. Read More

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December 2018