72,935 results match your criteria Meningitis


Comparative studies of catalytic pathways for Streptococcus pneumoniae sialidases NanA, NanB and NanC.

Sci Rep 2019 Feb 15;9(1):2157. Epub 2019 Feb 15.

School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW, 2500, Australia.

Streptococcus pneumoniae (S. pneumoniae) is a leading human pathogen, which takes large responsibility for severe otitis media, acute meningitis and septicaemia. It encodes up to three distinct sialidases: NanA, NanB and NanC, which are promising drug targets. Read More

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http://www.nature.com/articles/s41598-018-38131-z
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http://dx.doi.org/10.1038/s41598-018-38131-zDOI Listing
February 2019
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Expanded Endonasal Endoscopic Surgery in Suprasellar Craniopharyngiomas: A Retrospective Analysis of 43 Surgeries Including Recurrent Cases.

Oper Neurosurg (Hagerstown) 2019 Feb 15. Epub 2019 Feb 15.

Division of Neurosurgery, Toronto Western Hospital, University Health Network and Department of Surgery, University of Toronto, Toronto, Canada.

Background: The role of expanded endonasal endoscopic surgery for primary and recurrent craniopharyngioma is not yet fully established.

Objective: To report and evaluate our experience with the endoscopic endonasal approach (EEA) for the resection of primary and recurrent craniopharyngiomas.

Methods: This is a retrospective cohort analysis of 43 consecutive EEA procedures in 40 patients operated from September 2006 to February 2012 for suprasellar craniopharyngiomas. Read More

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http://dx.doi.org/10.1093/ons/opy356DOI Listing
February 2019

Structure and function of proprotein convertase subtilisin/kexin type 9 (PCSK9) in atherosclerosis.

Curr Drug Targets 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Baoji Center Hospital No. 8 Jiang Tan Road, Baoji 721008, Shaanxi. China.

Background: Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess cerebrospinal fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, blurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH.

Objective: The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitoring of effectiveness of employed therapeutic intervention for NPH. Read More

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http://dx.doi.org/10.2174/1389450120666190214141626DOI Listing
February 2019

Recent advances in rational diagnosis and treatment of normal pressure hydrocephalus: A critical appraisal on novel diagnostic, therapy monitoring and treatment modalities.

Curr Drug Targets 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Baoji Center Hospital No. 8 Jiang Tan Road, Baoji 721008, Shaanxi. China.

Background: Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess cerebrospinal fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, blurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH.

Objective: The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitoring of effectiveness of employed therapeutic intervention for NPH. Read More

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http://dx.doi.org/10.2174/1389450120666190214121342DOI Listing
February 2019

Long noncoding RNA expression profile from cryptococcal meningitis patients identifies DPY19L1p1 as a new disease marker.

CNS Neurosci Ther 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology and Venereology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Aims: LncRNAs play a vital role in the pathological and physiological process. This study aimed to explore the involvement of lncRNAs in cryptococcal meningitis.

Methods: Microarray was performed in cryptococcal meningitis patients, and then, GO and KEGG pathways were analyzed. Read More

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http://dx.doi.org/10.1111/cns.13109DOI Listing
February 2019

Zika Virus-Associated Aseptic Meningitis and Guillain-Barre Syndrome in a Traveler Returning from Latin America: a Case Report and Mini-Review.

Curr Infect Dis Rep 2019 Feb 15;21(1). Epub 2019 Feb 15.

Department of Medicine, University of Toronto, Toronto, Canada.

ZIKV-associated Guillain-Barré syndrome presents with an accelerated clinical course compared to classic post-infectious Guillain-Barré syndrome. Clinicians should anticipate and screen patients with ZIKV infection for neurologic complications bearing in mind that these may manifest during the acute viremic phase or during early convalescence. Read More

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http://dx.doi.org/10.1007/s11908-019-0661-1DOI Listing
February 2019

The Pathogenic Neisseria Use a Streamlined Set of Peptidoglycan Degradation Proteins for Peptidoglycan Remodeling, Recycling, and Toxic Fragment Release.

Front Microbiol 2019 31;10:73. Epub 2019 Jan 31.

Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States.

and release peptidoglycan (PG) fragments from the cell as the bacteria grow. For these PG fragments are known to cause damage to human Fallopian tube tissue in organ culture that mimics the damage seen in patients with pelvic inflammatory disease. also releases pro-inflammatory PG fragments, but in smaller amounts than those from . Read More

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http://dx.doi.org/10.3389/fmicb.2019.00073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365954PMC
January 2019

Clinical Spectrum of Central Nervous System Tuberculosis and the Efficacy of Revised National Tuberculosis Control Program in its Management.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):71-77

Senior Clinical Scientist, Department of Clinical Research, Dr. Agarwal's Healthcare Limited, Tirunelveli, Tamil Nadu, India.

Introduction: Tuberculosis (TB) is a major global problem and poses a threat which is of considerable magnitude, with an estimated one-third of the population infected with TB bacillus.

Aim: The aim of this study is to study the treatment outcomes in patients with various forms of neurological TB treated with the standardized Revised National TB Control Program (RNTCP), directly observed treatment short-course (DOTS).

Materials And Methods: Patients diagnosed to have TBM, tuberculoma with or without spinal arachnoiditis (central nervous system tuberculosis-TB [CNS-TB]) were categorized as per the RNTCP guidelines and received DOTS Category I or Category II thrice-weekly intermittent treatment as deemed appropriate. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_163_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337963PMC
February 2019

To Compare Diagnostic Ability of Contrast-Enhanced Three-Dimensional T1-SPACE with Three-Dimensional Fluid-Attenuated Inversion Recovery and Three-Dimensional T1-Magnetization Prepared Rapid Gradient Echo Magnetic Resonance Sequences in Patients of Meningitis.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):48-53

Department of Radiodiagnosis and Imaging, IGMC, Shimla, Himachal Pradesh, India.

Aims: The aim of this study is to compare postcontrast three-dimensional (3D) T1-Sampling perfection with application-optimized contrasts by using different flip angle evolutions, 3D fluid-attenuated inversion recovery (FLAIR), and 3D T1-magnetization prepared rapid gradient echo (MPRAGE) sequences in patients of meningitis.

Settings And Design: A hospital-based cross-sectional study done in the Department of Radiodiagnosis, IGMC Shimla for a period of 1 year from June 1, 2016, to May 30, 2017.

Subjects And Methods: A total of 30 patients suspected of meningitis underwent magnetic resonance imaging evaluation with postcontrast 3D T1-MPRAGE, 3D T1-SPACE, and 3D FLAIR sequences. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_157_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337966PMC
February 2019

Evaluation of matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS) for the Identification of Group B Streptococcus.

BMC Res Notes 2019 Feb 14;12(1):85. Epub 2019 Feb 14.

Section of Paediatrics, Department of Medicine, Imperial College London, London, UK.

Objective: Group B Streptococcus (GBS) is a leading cause of neonatal meningitis and sepsis worldwide. Intrapartum antibiotics given to women carrying GBS are an effective means of reducing disease in the first week of life. Rapid and reliable tests are needed to accurately identify GBS from these women for timely intrapartum antibiotic administration to prevent neonatal disease. Read More

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http://dx.doi.org/10.1186/s13104-019-4119-1DOI Listing
February 2019

More than just inflammation: Ureaplasma species induce apoptosis in human brain microvascular endothelial cells.

J Neuroinflammation 2019 Feb 14;16(1):38. Epub 2019 Feb 14.

University Children's Hospital, University of Wuerzburg, Josef-Schneider-Str. 2, 97080, Wuerzburg, Germany.

Background: Ureaplasma species (spp.) are commonly regarded as low-virulent commensals but may cause invasive diseases in immunocompromised adults and in neonates, including neonatal meningitis. The interactions of Ureaplasma spp. Read More

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http://dx.doi.org/10.1186/s12974-019-1413-8DOI Listing
February 2019

Evaluation of Next-Generation Sequencing for the Diagnosis of Infections of the Central Nervous System Caused by the Neurotropic Herpes Viruses: A Pilot Study.

Eur Neurol 2019 Feb 14;80(5-6):283-288. Epub 2019 Feb 14.

Medical School of Chinese PLA, Beijing, China.

Background: There are sparse and limited studies on small sample size reporting the application of next-generation sequencing (NGS) in the detection of central nervous system (CNS) viral infections. We assessed the diagnostic performance of NGS of cerebrospinal fluid (CSF) for predicting viral infections of the CNS caused by the neurotropic herpes viruses in a pilot population.

Materials And Methods: We prospectively collected CSF samples from 24 patients with CNS viral infection from April 2017 to October 2018. Read More

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http://dx.doi.org/10.1159/000497319DOI Listing
February 2019

Neutrophil to Lymphocyte Ratio and Mortality in Spinal Epidural Abscess.

Spine J 2019 Feb 11. Epub 2019 Feb 11.

Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School. Electronic address:

Background Context: Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio have been previously identified as markers for overall survival in oncology but remain heretofore unexplored in spinal epidural abscess (SEA).

Purpose: The purpose of this study was to determine the impact of these routinely collected assessments on ninety-day mortality in SEA.

Study Design/setting: Retrospective, case-control study PATIENT SAMPLE: Patients 18 years or older diagnosed with SEA at two academic medical centers and three community hospitals OUTCOME MEASURES: Ninety-day post-discharge and in-hospital mortality METHODS: Complete blood count with differential obtained on the day immediately preceding or on the day of admission was used to calculate platelet to lymphocyte and neutrophil to lymphocyte ratios. Read More

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http://dx.doi.org/10.1016/j.spinee.2019.02.005DOI Listing
February 2019

[Central Neurological Diagnosis in Patients Infected with HIV in the Infectious Diseases Unit of University Hospital of Casablanca, Morocco].

Bull Soc Pathol Exot 2018 ;111(1):24-30

Service des maladies infectieuses, CHU de Ibn Rochd, Casablanca, Maroc.

The aim of this work is to study the epidemiology of central neurological system (CNS) diagnosed in the population of people living with HIV in the department of infectious diseases in UHC Ibn Rochd of Casablanca from January 2005 to May 2015. The demographic and clinical profile along with the outcome of these patients were studied. The data were collected from Nadis software. Read More

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http://dx.doi.org/10.3166/bspe-2018-0004DOI Listing
January 2018

The role of CNS macrophages in streptococcal meningoencephalitis.

J Leukoc Biol 2019 Feb 14. Epub 2019 Feb 14.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany.

In the healthy brain, microglia and other CNS macrophages are the most abundant immune cell type. Thus, they form the natural immune cell interface with streptococci, which are the leading cause of bacterial meningitis and encephalitis in infants and young children. In homeostasis, the blood-brain barrier allows for very limited access of immune cells circulating in the periphery. Read More

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http://dx.doi.org/10.1002/JLB.4MR1118-419RDOI Listing
February 2019

Neurobiology of Photophobia.

J Neuroophthalmol 2019 Mar;39(1):94-102

Department of Anesthesia and Critical Care (RB, RN), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology (ABF), Children's Hospital Boston, Boston, Massachusetts.

Background: Photophobia is commonly associated with migraine, meningitis, concussion, and a variety of ocular diseases. Advances in our ability to trace multiple brain pathways through which light information is processed have paved the way to a better understanding of the neurobiology of photophobia and the complexity of the symptoms triggered by light.

Purpose: The purpose of this review is to summarize recent anatomical and physiological studies on the neurobiology of photophobia with emphasis on migraine. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000766DOI Listing

Elimination of Epidemic Meningitis in the African Region: Progress and Challenges: 2010-2016.

J Immunol Sci 2018 Jul;Suppl:41-45

IVD/FRH, WHO Regional Office for Africa, Brazzaville, Congo.

Background: Epidemics of meningococcal disease constitute a major public health challenge in Africa, affecting mostly the 24 countries of the meningitis belt. These epidemics led to a call for a call for a safe, effective and affordable conjugate vaccine against the major serogroup responsible for recent epidemics by leaders of the region.

Objective: This paper documents experiences with efforts at eliminating epidemic meningitis in the African Region. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370001PMC

Resistance and Tolerance to Cryptococcal Infection: An Intricate Balance That Controls the Development of Disease.

Front Immunol 2019 29;10:66. Epub 2019 Jan 29.

Translational Research in Respiratory Diseases Program, Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.

is a ubiquitous environmental yeast and a leading cause of invasive fungal infection in humans. The most recent estimate of global disease burden includes over 200,000 cases of cryptococcal meningitis each year. expresses several virulence factors that may have originally evolved to protect against environmental threats, and human infection may be an unintended consequence of these acquired defenses. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361814PMC
January 2019

Pediatric meningococcocal meningitis in the acute phase: how much does it cost?

Ital J Pediatr 2019 Feb 13;45(1):25. Epub 2019 Feb 13.

Pediatric and Infectious Disease Unit, Bambino Gesù Children Hospital, Rome, Italy.

Background: Meningococcal meningitis (MM) is known to be responsible of high cost for the Public Health Administration. Aim of the work is to calculate the costs for the hospitalization of pediatric patients affected by MM.

Methods: We calculate the costs for the hospitalization of pediatric patients affected by MM in the acute phase (HAP) over a nine year period. Read More

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http://dx.doi.org/10.1186/s13052-019-0616-zDOI Listing
February 2019

Hemoptysis in the Immunocompromised Patient: Do Not Forget Strongyloidiasis.

Trop Med Infect Dis 2019 Feb 12;4(1). Epub 2019 Feb 12.

Department of Medicine, Division of Infectious Diseases, University of Texas Health, San Antonio, TX 78229, USA.

Strongyloidiasis, due to infection with the nematode , affects millions of people in the tropics and subtropics. has a unique auto-infective lifecycle such that it can persist in the human host for decades. In immunosuppressed patients, especially those on corticosteroids, potentially fatal disseminated strongyloidiasis can occur, often with concurrent secondary infections. Read More

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http://dx.doi.org/10.3390/tropicalmed4010035DOI Listing
February 2019

Vogt-Koyanagi-Harada Disease, a Rare Entity in Spain: The Challenge of Worldwide Immigration and Globalization.

Eur J Case Rep Intern Med 2018 26;5(7):000886. Epub 2018 Jul 26.

Ophthalmology Department, Baza Hospital, Granada, Spain.

Vogt-Koyanagi-Harada disease is rare, mediated by autoimmune melanocyte inflammation and facilitated by genetic predisposition. The main clinical features include uveitis, meningitis, tinnitus and sensorineural deafness, and skin and hair depigmentation. It usually develops in four consecutive stages: prodromal, acute uveitic, convalescent, and chronic or recurrent. Read More

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http://dx.doi.org/10.12890/2018_000886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346778PMC

Cerebral Vasculitis Complicating Pneumococcal Meningitis.

Eur J Case Rep Intern Med 2018 25;5(5):000819. Epub 2018 May 25.

Medical Intensive Care Unit, Farhat Hached Hospital, Sousse, Tunisia.

Introduction: Cerebral vasculitis is an uncommon life-threatening complication of community-acquired bacterial meningitis.

Patient And Methods: We report the case of a 64-year-old woman with pneumococcal meningitis who developed parainfectious vasculitis causing ischaemic brain damage. Cerebral magnetic resonance imaging (MRI) confirmed the diagnosis. Read More

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http://dx.doi.org/10.12890/2018_000819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346924PMC

Cryptococcal Meningitis in a HIV-Negative Patient.

Eur J Case Rep Intern Med 2018 22;5(2):000778. Epub 2018 Feb 22.

Internal Medicine Department, Serviço de Medicina 1, Unidade Local de Saúde do Alto Minho, EPE, Portugal.

Sarcoidosis is a risk factor for the development of cryptococcal infection due to dysfunction at T-cell level. Its rarity may, however, delay diagnosis and treatment. We describe the case of a 60-year-old man, diagnosed with sarcoidosis since 1999. Read More

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http://dx.doi.org/10.12890/2017_000778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346933PMC
February 2018

An Overview on Epidemiology of Tuberculosis.

Mymensingh Med J 2019 Jan;28(1):259-266

Dr Mohammad Kamruzzaman Khan, Lecturer, Department of Community Medicine, Mymensingh Medical College (MMC), Mymensingh, Bangladesh; E-mail: kamruz

Tuberculosis (TB) is a progressive granulomatous infectious disease caused by the gram positive, acid fast bacilli classified under the genus Mycobacterium. Tuberculosis in human is mostly by Mycobacterium tuberculosis and primarily affects lungs causing pulmonary tuberculosis. It can also affect intestine, meninges, bones, joints, lymph nodes, skin and other tissues of the body causing extra-pulmonary tuberculosis. Read More

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January 2019
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VGIIa Infection Associated with Travel to the Pacific Northwest Outbreak Region in an Anti-Granulocyte-Macrophage Colony-Stimulating Factor Autoantibody-Positive Patient in the United States.

MBio 2019 Feb 12;10(1). Epub 2019 Feb 12.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA

The region encompassing the Pacific Northwest (PNW), Vancouver Island, Oregon, and Washington has been the location of an ongoing outbreak since the 1990s, and there is evidence that the outbreak is expanding along the West Coast into California. Here we report a clinical case of a 69-year-old, HIV-negative man from North Carolina who was diagnosed with a fungal brain mass by magnetic resonance imaging (MRI) and pathology. He had traveled to Seattle and Vancouver 3 years earlier and to Costa Rica 4 months prior to presentation. Read More

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http://dx.doi.org/10.1128/mBio.02733-18DOI Listing
February 2019
2 Reads

Complementary Role of CD4+ T Cells in Response to Pneumococcal Polysaccharide Vaccines in Humans.

Vaccines (Basel) 2019 Feb 11;7(1). Epub 2019 Feb 11.

Mucosal and Vaccine Research Program Colorado (MAVRC), Infectious Diseases, University of Colorado Denver, Aurora, CO 80045, USA.

Bacterial pathogens expressing capsular polysaccharides are common causes of mucosal infections (pneumonia, intestinal), as well as often fatal, invasive infections (meningitis, bloodstream infections) in children and adults worldwide. These chemically simple but structurally complex carbohydrate structures on the bacterial surface confer resistance to recognition and clearance by the immune system through a range of mechanisms. Such recognition of capsular polysaccharides may be reduced by their limited ability to directly stimulate B cells and the T cells that may facilitate these humoral responses. Read More

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http://dx.doi.org/10.3390/vaccines7010018DOI Listing
February 2019

Elevated Matrix Metalloproteinase Concentrations Offer Novel Insight Into Their Role in Pediatric Tuberculous Meningitis.

J Pediatric Infect Dis Soc 2019 Feb 12. Epub 2019 Feb 12.

Division of Neurosurgery, Department of Surgery.

We collected lumbar and ventricular cerebrospinal fluid and serum from 40 children treated for tuberculous meningitis and measured the concentrations of gelatinases and their inhibitors. The concentrations of matrix metalloproteinase 9 (MMP-9), MMP-2, tissue inhibitor of metalloproteinase 1 (TIMP-1), and TIMP-2 were significantly elevated in the lumbar CSF samples, and we found interesting dynamics for MMP-9 that offer novel insight into its role in pediatric patients with tuberculous meningitis. Read More

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http://dx.doi.org/10.1093/jpids/piy141DOI Listing
February 2019
1 Read

Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis.

J Med Chem 2019 Feb 12. Epub 2019 Feb 12.

Clinical treatment of cryptococcal meningitis (CM) remains a significant challenge due to the lack of effective and safe drug therapies. Developing novel CM therapeutic agents with novel chemical scaffolds and new modes of action is of great importance. Herein, new β-hexahydrocarboline derivatives were shown to possess potent anticryptococcal activities. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.8b01598DOI Listing
February 2019
1 Read

Protean Neurologic Manifestations of Two Rare Dermatologic Disorders: Sweet Disease and Localized Craniofacial Scleroderma.

Curr Neurol Neurosci Rep 2019 Feb 12;19(3):11. Epub 2019 Feb 12.

NYU Multiple Sclerosis Comprehensive Care Center, Department of Neurology, New York University School of Medicine, New York, NY, USA.

Purpose Of Review: To describe diverse neurologic and neuroradiologic presentations of two rare, immunologically mediated skin conditions: Sweet disease and localized scleroderma (morphea).

Recent Findings: Core syndromes of neuro-Sweet disease (NSD) are steroid responsiveness, recurrent meningitis, and encephalitis. Focal neurologic, neuro-vascular, and neuro-ophthalmologic syndromes have been reported recently in NSD. Read More

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http://dx.doi.org/10.1007/s11910-019-0929-8DOI Listing
February 2019
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Disseminated cryptococcosis with immunoglobulin G subclass deficiency.

Pediatr Int 2019 Feb 11. Epub 2019 Feb 11.

Division of Pediatric Infectious Disease, Department of Pediatrics, St Joseph's Children's Hospital, Paterson, New Jersey, USA.

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http://dx.doi.org/10.1111/ped.13741DOI Listing
February 2019
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Multidrug-resistant tuberculous meningitis in a returned traveller.

J Paediatr Child Health 2019 Feb 11. Epub 2019 Feb 11.

Department of Infectious Diseases and Microbiology, Children's Hospital at Westmead, Sydney, New South Wales, Australia.

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http://doi.wiley.com/10.1111/jpc.14387
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http://dx.doi.org/10.1111/jpc.14387DOI Listing
February 2019
2 Reads

The occurrence of cardiac abnormalities in canine steroid-responsive meningitis arteritis.

J Small Anim Pract 2019 Feb 11. Epub 2019 Feb 11.

Small Animal Hospital, University of Glasgow, Glasgow G61 1QH, UK.

Objectives: To document the prevalence of cardiac abnormalities in dogs with steroid-responsive meningitis arteritis and to assess resolution of these abnormalities following corticosteroid therapy.

Materials And Methods: Steroid-responsive meningitis arteritis was diagnosed based on signalment, physical examination findings, complete blood count, biochemistry and CSF analysis. Echocardiography, C-reactive protein and cardiac troponin I were measured in all cases before and 10 to 14 days after commencing corticosteroid therapy. Read More

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http://dx.doi.org/10.1111/jsap.12984DOI Listing
February 2019
1 Read

Dilemma in Diagnosis of Pyogenic Meningitis in Cerebrospinal Fluid Contaminated with Blood: Does Leucocyte Esterase Test Help?

J Cytol 2019 Jan-Mar;36(1):44-47

Department of Pediatrics, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

Context: Pyogenic meningitis is often a devastating condition which is diagnosed by analysis of cerebrospinal fluid (CSF) obtained by lumbar puncture (LP). CSF thus obtained can get contaminated with peripheral blood leucocytes during LP which renders it unusable for cytological analysis. Leucocyte esterase strips are available for identifying leucocyte esterase activity in urine and other body fluids which suggest inflammation. Read More

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http://dx.doi.org/10.4103/JOC.JOC_75_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343398PMC
February 2019
1 Read

Defining the role of the Sht-family proteins in zinc acquisition and complement evasion.

J Bacteriol 2019 Feb 11. Epub 2019 Feb 11.

ISP, Université de Tours, INRA, UMR1282, F-37032 Tours, France

is part of the human intestinal and uro-genital microbiota, but also a leading cause of septicemia and meningitis in neonates. Its ability to cause disease depends upon the acquisition of nutrients from its environment, including the transition metal ion zinc. The primary zinc acquisition system of the pathogen is the Adc/Lmb ABC permease, which is essential for viability in zinc-restricted environments. Read More

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http://dx.doi.org/10.1128/JB.00757-18DOI Listing
February 2019

Antibody kinetics following vaccination with MenAfriVac: an analysis of serological data from randomised trials.

Lancet Infect Dis 2019 Feb 8. Epub 2019 Feb 8.

Disease Dynamics Unit, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Background: A meningococcal group A conjugate vaccine, PsA-TT (also known as MenAfriVac), was developed with the support of the Meningitis Vaccine Project. Around 280 million individuals aged 1-29 years have been immunised across the African meningitis belt. We analysed the kinetics of vaccine-induced antibody response and assessed the possible implications for duration of protection. Read More

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http://dx.doi.org/10.1016/S1473-3099(18)30674-1DOI Listing
February 2019
2 Reads

Integrating exosomal microRNAs and electronic health data improved tuberculosis diagnosis.

EBioMedicine 2019 Feb 7. Epub 2019 Feb 7.

Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address:

Background Tuberculosis (TB) is difficult to diagnose under complex clinical conditions as electronic health records (EHRs) are often inadequate in making an affirmative diagnosis. As exosomal miRNAs emerged as promising biomarkers, we investigated the potential of using exosomal miRNAs and EHRs in TB diagnosis.

Methods: A total of 370 individuals, including pulmonary tuberculosis (PTB), tuberculous meningitis (TBM), non-TB disease controls and healthy state controls, were enrolled. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523964193002
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http://dx.doi.org/10.1016/j.ebiom.2019.01.023DOI Listing
February 2019
2 Reads

Chiari malformations in adults: A single center surgical experience with special emphasis on the kinetics of clinical improvement.

Neurochirurgie 2019 Feb 8. Epub 2019 Feb 8.

Service de neurochirurgie, hôpital Nord, 13015 Marseille, France.

Background: The Chiari malformation type I (CM-I) is the most commonly found type in adults. The efforts to further improve the treatment offered for these malformations are hampered by the existence of controversial methods and the absence of a uniform scoring system to evaluate clinical outcomes.

Objectives: The goal of our study is to analyze the clinical and radiological data concerning patients operated for CM and to expose surgical techniques. Read More

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http://dx.doi.org/10.1016/j.neuchi.2018.10.010DOI Listing
February 2019

[Analysis of common pathogens and epidemiological characteristics of acute bacterial meningitis cases in Shandong Province].

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Feb;53(2):179-184

Division of Expanded Immunization Program, Shandong Center for Disease Control and Prevention; Academy of Preventive Medicine, Shandong University; Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Jinan 250014, China.

To analyze epidemiological characteristics of acute bacterial meningitis (ABM) cases and the common pathogens infected in Jinan, Shandong Province. Epidemiological and clinical informations and cerebrospinal fluid (CSF) and blood specimens of acute meningitis/encephalitis syndrome (AMES) cases (total 3 918 cases) were collected in the six sentinel hospitals from 2013 to 2016. , and were detected by the methods of real-time fluorescent quantitative polymerase chain reaction (Real-time PCR), bacterial culture and latex agglutination. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.02.011DOI Listing
February 2019
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[Etiologic surveillance and analysis of acute meningitis and encephalitis syndrome in Jinan city in 2013-2016].

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Feb;53(2):174-178

Division of Expanded Immunization Program, Shandong Center for Disease Control and Prevention; Academy of Preventive Medicine, Shandong University; Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Jinan 250014, China.

To characterize the etiology and epidemiological characteristics of the acute meningitis and encephalitis syndrome (AMES) in Jinan city in 2013-2016. The epidemiological data, clinical diagnosis, serum and cerebrospinal fluid (CSF) specimens were collected from 3 577 AMES cases in 6 sentinel hospitals in Jinan city in 2013-2016. Samples of all cases were made sero-diagnosis for Immunoglobulin (Ig) M antibody to Japanese encephalitis virus (JEV) and negative cases of JEV for enterovirus (EV), mumps virus (MuV) and herpes simplex virus (HSV) by enzyme-linked immunosorbent assay (ELISA). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.02.010DOI Listing
February 2019
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[Analysis of current epidemiological and clinical characteristics for laboratory confirmed epidemic cerebrospinal meningitis cases in Shandong Province, 2007-2016].

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Feb;53(2):169-173

Division of Expanded Immunization Program, Shandong Center for Disease Control and Prevention; Academy of Preventive Medicine, Shandong University; Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Jinan 250014, China.

To analyze epidemiological and clinical characteristics of laboratory confirmed epidemic cerebrospinal meningitis cases. Epidemiological and clinical informations and cerebrospinal fluid (CSF) and blood specimens of AMES (acute meningitis/encephalitis syndrome) cases were collected in the six sentinel hospitals from 2007 to 2016. () species and serogroup identification were detected by the methods of real-time fluorescent quantitative polymerase chain reaction (Real-time PCR) and bacterial culture, and epidemiological and clinical characteristics of laboratory confirmed epidemic cerebrospinal meningitis cases were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.02.009DOI Listing
February 2019
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[Acute meningitis and encephalitis syndrome surveillance disease burden in four China prefectures].

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Feb;53(2):164-168

Department of National Immunization Programme, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

To explore acute meningitis and encephalitis syndrome (AMES) surveillance in 4 China prefectures, to understand the epidemiological features and disease burden of () meningitis, () meningitis, haemophilus influenza type b (Hib) meningitis and Japanese encephalitis and provide evidence for related disease prevention and control. AMES surveillance were conducted in Jinan, Shandong Province and Yichang, Hubei Province in September 2006, and in 13 districts of Shijiazhuang, Hebei Province and Guigang City, Guangxi Zhuang Autonomous Region in April 2007. Six hospitals in each city were selected as monitoring pilot hospitals to carry out reports of suspected cases of acute meningitis and encephalitis, case investigation, blood specimens and cerebrospinal fluid specimen collection, anti-JEV IgM antibody enzyme-linked immunosorbent assay, , and Hib culture and polymerase chain reaction detection, etc. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.02.008DOI Listing
February 2019
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[Analysis of epidemic characteristics for meningococcal meningitis in China during 2015-2017].

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Feb;53(2):159-163

Department of National Immunization Programme, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

To analyze the characteristics of epidemiology and () serogroups distribution for meningococcal meningitis (MM) cases in China from 2015 to 2017. The data of MM cases were collected from National Notifiable Diseases Registry System (NNDRS) and case-based MM surveillance system (MMSS) from 2015 to 2017; Demographic data are from the National Bureau of statistics. Inclusion criteria: the date of onset was January 1, 2015 to December 31, 2017, the status of infectious disease report card was "final examination card", the cases are classified as "laboratory confirmed cases" and "clinical diagnostic cases", and the card data information of disease name was "Meningococcal meningitis". Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.02.007DOI Listing
February 2019

[Efficacy, safety, and cost-effectiveness of meningococcal vaccines].

Authors:

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Feb;53(2):146-152

Meningococcal meningitis is an acute, severe respiratory infectious disease caused by Neisseria meningitidis. Immunization with meningococcal vaccine is the most effective measure to control and prevent transmission of meningococcal meningitis. Meningococcal vaccines in the Chinese market include meningococcal polysaccharide vaccine, meningococcal polysaccharide conjugate vaccine, and a combined vaccine containing meningococcal polysaccharide conjugate vaccine. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.02.005DOI Listing
February 2019

[Experts' consensus on immunization with meningococcal vaccines in China].

Authors:

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Feb;53(2):141-145

Meningococcal vaccines in the Chinese market include meningococcal polysaccharide vaccine, meningococcal polysaccharide conjugate vaccine, and a combined vaccine. Meningococcal conjugate vaccines immunization schedules vary by vaccine manufacturer, and often cause confusion in immunization practices. Based on the epidemiological characteristics of meningococcal disease, serogroup distribution of Neisseria meningitidis, and research progress on the immunogenicity and safety of meningococcal vaccines, we developed an experts' consensus on immunization with meningococcal vaccines to provide guidance for immunization providers and for centers for disease control and prevention staff. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.02.004DOI Listing
February 2019

[Efficacy, safety, and cost-effectiveness of meningococcal vaccines].

Authors:

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Feb;40(2):129-135

Meningococcal meningitis is an acute, severe respiratory infectious disease caused by . Immunization with meningococcal vaccine is the most effective measure to control and prevent transmission of meningococcal meningitis. Meningococcal vaccines in the Chinese market include meningococcal polysaccharide vaccine, meningococcal polysaccharide conjugate vaccine, and a combined vaccine containing meningococcal polysaccharide conjugate vaccine. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.02.002DOI Listing
February 2019

[Experts' consensus on immunization with meningococcal vaccines in China].

Authors:

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Feb;40(2):123-128

Meningococcal vaccines in the Chinese market include meningococcal polysaccharide vaccine, meningococcal polysaccharide conjugate vaccine, and a combined vaccine. Meningococcal conjugate vaccines immunization schedules vary by vaccine manufacturer, and often cause confusion in immunization practices. Based on the epidemiological characteristics of meningococcal disease, serogroup distribution of , and research progress on the immunogenicity and safety of meningococcal vaccines, we developed an experts' consensus on immunization with meningococcal vaccines to provide guidance for immunization providers and for centers for disease control and prevention staff. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.02.001DOI Listing
February 2019

Evaluation and Management of the Emergency Department Headache.

Semin Neurol 2019 Feb 11;39(1):20-26. Epub 2019 Feb 11.

Department of Emergency Medicine, Maricopa Medical Center, Phoenix, Arizona.

The acute headache in the emergency department (ED) poses a diagnostic dilemma that may overwhelm providers attempting to weigh the cost of advanced workups against the risk of missing serious pathology. While the majority of headache concerns are benign primary headache disorders, identifying life-threatening secondary causes of headache-which may be broadly categorized into structural, infectious, and vascular causes-is the primary focus of evaluation in the ED. Secondary headaches are associated with a high morbidity and mortality, and require strict scrutiny of the history and physical examination to adequately risk-stratify patients. Read More

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http://dx.doi.org/10.1055/s-0038-1677023DOI Listing
February 2019
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Medical Malpractice of Vestibular Schwannoma: A 40-Year Review of the United States Legal Databases.

Otol Neurotol 2019 Mar;40(3):391-397

Department of Otolaryngology-Head and Neck Surgery.

Objectives: To analyze medical malpractice lawsuit trends pertaining to cases of vestibular schwannomas (VS).

Methods: Two major computerized legal databases (LexisNexis and WestLaw) were queried and reviewed for evaluation of all the US state and federal court records from civil trials alleging malpractice between 1976 and 2016.

Results: A total of 32 VS cases were identified. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002133DOI Listing
March 2019
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Endoscopic endonasal surgery for Clival Chordomas - a single institution experience and short term outcomes.

Br J Neurosurg 2019 Feb 11:1-6. Epub 2019 Feb 11.

a Department of Neurosurgery , Birmingham University Hospital , Birmingham , England.

Purpose: Clival Chordomas are locally aggressive tumours which pose a significant treatment challenge. Endoscopic endonasal approach for clival chordomas is correlated with higher resection rates and lower morbidity rates in comparison to open approaches. We present our initial single institution experience and short-term patient outcomes following endoscopic endonasal approach for resection of clival chordomas. Read More

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http://dx.doi.org/10.1080/02688697.2019.1567683DOI Listing
February 2019

A Syrian Refugee in Iraq Diagnosed as a Case of IL12RB1 Deficiency in Japan Using Dried Blood Spots.

Front Immunol 2019 25;10:58. Epub 2019 Jan 25.

Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.

Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare condition of primary immunodeficiency disorder. Interleukin-12 receptor β1 (IL12RB1) deficiency, is the most common genetic etiology of MSMD, which is characterized by the selective predisposition to clinical disease caused by weakly-virulent mycobacteria, such as Bacillus Calmette-Guérin (BCG) vaccines, and environmental non-tuberculous mycobacteria (NTM). To the best of our knowledge, this is the first case of deficiency to be reported from Iraq. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355664PMC
January 2019
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