73,344 results match your criteria Meningitis


Arenaviruses and West Nile Virus in Solid Organ Transplant Recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

Clin Transplant 2019 Apr 25:e13576. Epub 2019 Apr 25.

Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA.

These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the epidemiology, diagnosis, prevention, and management of infection due to Arenaviruses and West Nile Virus (WNV) in the pre- and post-transplant period. Arenaviruses and WNV have been identified as causes of both donor-derived and post-transplant infection. Most data related to these infections have been published in case reports and case series. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ctr.13576DOI Listing
April 2019
1 Read

Neuropsychiatric Syndromes in Childhood-Onset Systemic Lupus Erythematosus: A Systematic Review and Meta-analysis.

J Clin Rheumatol 2019 Apr 22. Epub 2019 Apr 22.

Mental Health, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Objective: The aim of this study was to access the prevalence of 19 neuropsychiatric syndromes in childhood-onset systemic lupus erythematosus (cSLE), as defined by the American College of Rheumatology (ACR) in 1999, by performing a systematic review and meta-analysis of relevant publications.

Methods: A literature search from April 1999 to March 2018 identified studies investigating neuropsychiatric syndromes in cSLE patients, applying 1999 ACR Case Definitions, with a sample of at least 20 patients. Case reports, small case series, reviews, articles that did not use 1999 ACR case definitions, and those with adult SLE patients were excluded. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RHU.0000000000001029DOI Listing

Update and advances in community acquired bacterial meningitis.

Authors:
Rodrigo Hasbun

Curr Opin Infect Dis 2019 Jun;32(3):233-238

Section of Infectious Diseases, UT Health McGovern Medical School, Houston, Texas, USA.

Purpose Of Review: Community-acquired bacterial meningitis continues to occur and be associated with significant morbidity and mortality despite the availability of effective conjugate vaccines for the three most important meningeal pathogens.

Recent Findings: Indications for cranial imaging in suspected bacterial meningitis varies significantly between guidelines. Cranial imaging is of no clinical utility in those patients without indications and fosters delays in performing a lumbar puncture. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QCO.0000000000000543DOI Listing
June 2019
1 Read

Human Astrovirus MLB replication : persistence in extra-intestinal cell lines.

J Virol 2019 Apr 24. Epub 2019 Apr 24.

Enteric Virus Laboratory, Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Spain; Nutrition and Food Safety Research Institute (INSA⋅UB), University of Barcelona, Barcelona, Spain

MLB astroviruses were identified 10 years ago in feces from children with gastroenteritis of unknown etiology, and have been unexpectedly detected in severe cases of meningitis/encephalitis, febrile illness of unknown etiology and respiratory syndromes. The aim of this study was to establish a cell culture system supporting MLB astrovirus replication. We used two clinical strains to infect several cell lines: a MLB1 strain from a gastroenteritis case, and a MLB2 strain associated with a neurologic infection. Read More

View Article

Download full-text PDF

Source
http://jvi.asm.org/lookup/doi/10.1128/JVI.00557-19
Publisher Site
http://dx.doi.org/10.1128/JVI.00557-19DOI Listing
April 2019
1 Read

Transplacental transmission of Neospora caninum in moose (Alces alces).

Vet Parasitol Reg Stud Reports 2017 Aug 8;9:41-46. Epub 2017 Apr 8.

Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Epidemiology, Greifswald-Insel Riems, Germany. Electronic address:

A 5-years-old moose (Alces alces) cow kept in a zoo in the German Federal State of Brandenburg aborted a female foetus of 44cm crown rump length (CRL). Pathohistological analysis revealed several Neospora (N.) caninum infected cells and cysts, as well as multifocal gliosis, necrosis, haemorrhages, dystrophic mineralisation and haemosiderosis in the brain, predominantly in cerebrum and brainstem. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vprsr.2017.04.006DOI Listing

Performance of lactate in discriminating bacterial meningitis from enteroviral meningitis.

Rev Inst Med Trop Sao Paulo 2019 Apr 18;61:e24. Epub 2019 Apr 18.

Senne Líquor Diagnóstico, São Paulo, São Paulo, Brazil.

The cytological and biochemical examination of cerebrospinal fluid (CSF) has been used for the presumed diagnosis of bacterial meningitis until the final microbiological results are achieved. We assessed the ability of CSF lactate in comparison with other CSF parameters to discriminate bacterial and enteroviral community acquired meningitis. We included 1,187 CSF samples of acute community-acquired meningitis, being 662 cases of bacterial and 525 of enteroviral meningitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/S1678-9946201961024DOI Listing

[Advances in pathogenic mechanisms of infection].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Mar;31(1):98-104

Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China.

Angiostrongylosis, a food-borne parasitic disease, is caused by the migration of larvae of to the host's central nervous system after it is infected. It is a serious disease with eosinophilic encephalitis and meningoencephalitis as the main clinical manifestations. Understanding of its pathogenic mechanism is important for the prevention and treatment of angiostrongylosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.16250/j.32.1374.2018305DOI Listing

A blind passenger: a rare case of documented seroconversion in an induced eosinophilic meningitis in a traveler visiting friends and relatives.

Trop Dis Travel Med Vaccines 2019 15;5. Epub 2019 Apr 15.

1Department of Medicine, Swiss Tropical and Public Health Institute, Basel, Switzerland.

Background: Eosinophilic meningitis (EOM) is a rare condition that is caused by various communicable and non-communicable factors. The rat-lungworm , which is associated with consumption of raw or undercooked paratenic or intermediate hosts, is the most common cause of parasitic eosinophilic meningitis worldwide. While the majority of cases are reported from endemic regions, cases in travelers pose a challenge to clinicians in non-endemic countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40794-019-0084-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466724PMC
April 2019
1 Read

Use of ventriculostomy in the treatment of septic cavernous sinus thrombosis (SCST).

BMJ Case Rep 2019 Apr 23;12(4). Epub 2019 Apr 23.

Division of Neurosurgery, Ascension Providence Hospital, College of Human Medicine, Michigan State University, Southfield, Michigan, USA.

We present a novel treatment with the use of intraventricular antibiotics delivered through a ventriculostomy in a patient who developed septic cavernous sinus thrombosis after sinus surgery. A 65-year-old woman presented with acute on chronic sinusitis. The patient underwent a diagnostic left maxillary antrostomy, ethmoidectomy, sphenoidotomy and sinusotomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-228929DOI Listing

Cryptococcal Meningoencephalitis Presenting as a Psychiatric Emergency.

J Emerg Med 2019 Apr 20. Epub 2019 Apr 20.

Department of Emergency Medicine, Yale School of Medicine, New Haven, Connecticut.

Background: Organic conditions can often mimic neuropsychiatric disorders, leading to delays in diagnosis and treatment for the most vulnerable populations presenting to the emergency department (ED).

Case Report: Here we discuss a case of cryptococcal meningoencephalitis seemingly consistent with psychosis on initial evaluation, and present strategies to recognize and treat this condition. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Due to the indolent time course of this disease, initial symptoms of altered mental status and personality changes may be attributed to drug use or psychiatric illness before more overt evidence for increased intracranial pressure and neurologic infection develops. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jemermed.2019.03.016DOI Listing
April 2019
1.175 Impact Factor

Fungal Endophthalmitis after Intravitreal Injections of Triamcinolone Contaminated by a Compounding Pharmacy: Five-Year Follow-up of 23 Patients.

Ophthalmol Retina 2019 Feb 21;3(2):133-139. Epub 2018 Sep 21.

Macula and Retina Institute, Los Angeles and Glendale, California; Molecular Insight Research Foundation, Los Angeles and Glendale, California.

Purpose: To report the 5-year outcome of an outbreak of Bipolaris hawaiiensis fungal endophthalmitis caused by contamination of intravitreal triamcinolone from Franck's Compounding Pharmacy in Ocala, Florida.

Design: Retrospective case series.

Participants: Twenty-three patients (n = 25 eyes). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oret.2018.09.009DOI Listing
February 2019

Trends in Antimicrobial Drug Resistance of Isolates at Jordan University Hospital (2000⁻2018).

Antibiotics (Basel) 2019 Apr 12;8(2). Epub 2019 Apr 12.

Department of Translational Medicine, Faculty of Medicine, Lund University, 22362 Malmö, Sweden.

Antimicrobial drug resistance (AMR) in pneumococci complicates the treatment of serious pneumococcal infections. Country-specific AMR patterns can help to establish guidelines for empiric therapy. The aim of the current study was to analyze the distribution of AMR among isolates at Jordan University Hospital (JUH) during 2000⁻2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/antibiotics8020041DOI Listing
April 2019
5 Reads

Administration of Vancomycin at High Doses in Patients with Post Neurosurgical Meningitis: A Comprehensive Comparison between Continuous Infusion and Intermittent Infusion.

Iran J Pharm Res 2018 ;17(Suppl2):195-205

Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Poor penetration of vancomycin into Central Nervous System (CNS) can lead to treatment failure. The aim of this study was to evaluate and compare CSF concentration and serum pharmacokinetics of high dose vancomycin by continuous infusion intermittent infusion in post neurosurgical meningitis patients. Twenty patients were divided into two groups. Read More

View Article

Download full-text PDF

Source
January 2018

Innate Immune Responses to in the Airway.

J Interferon Cytokine Res 2019 Apr 23. Epub 2019 Apr 23.

Department of Pathology and Laboratory Medicine, Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, New Jersey.

is an emerging opportunistic pathogen that has risen to become a serious global threat, prevalent in health care settings and the community, which results in high morbidity and mortality rates. Its alarming expansion of antibiotic resistance is one of the most problematic traits of and as so, this bacterium has been classified as a serious threat and high priority target by the CDC. The most common types of infections induced by this pathogen include pneumonia (both hospital and community acquired), bacteremia, skin and soft tissue, urinary tract infections, endocarditis, and meningitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/jir.2019.0008DOI Listing

Group B streptococcus prevalence, serotype distribution and colonization dynamics in Western Australian pregnant women.

J Med Microbiol 2019 Apr 23. Epub 2019 Apr 23.

1 The School of Medicine, Division of Obstetrics and Gynaecology, The University of Western Australia, Australia.

Purpose: Streptococcus agalactiae, or group B streptococcus (GBS), is a leading neonatal pathogen that causes sepsis, meningitis and pneumonia. Globally, strategies have been implemented to address vertical transmission, and in Western Australia (WA), culture-based screening at 35-37 weeks' gestation is part of routine care and guides antibiotic administration. Previous Australian studies have focused on other regions or included low sample-size representatives; we aimed to describe antenatal GBS colonization in WA. Read More

View Article

Download full-text PDF

Source
https://www.microbiologyresearch.org/content/journal/jmm/10.
Publisher Site
http://dx.doi.org/10.1099/jmm.0.000980DOI Listing
April 2019
1 Read

Safety profile of the RTS,S/AS01 malaria vaccine in infants and children: additional data from a phase III randomized controlled trial in sub-Saharan Africa.

Hum Vaccin Immunother 2019 Apr 23:1-13. Epub 2019 Apr 23.

a GSK , Wavre , Belgium.

A phase III, double-blind, randomized, controlled trial (NCT00866619) in sub-Saharan Africa showed RTS,S/AS01 vaccine efficacy against malaria. We now present in-depth safety results from this study. 8922 children (enrolled at 5-17 months) and 6537 infants (enrolled at 6-12 weeks) were 1:1:1-randomized to receive 4 doses of RTS,S/AS01 (R3R) or non-malaria control vaccine (C3C), or 3 RTS,S/AS01 doses plus control (R3C). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21645515.2019.1586040DOI Listing

Successful lung donation at the age of 6 weeks: Challenges and lessons learned.

Pediatr Transplant 2019 Apr 23:e13419. Epub 2019 Apr 23.

Royal Papworth Hospital, Cambridge, UK.

A clinical case of successful procurement and transplantation of bilateral lungs from 6-week-old infant with sepsis secondary to bacterial meningitis is reported. Forty-one-day-old male infant (height 60 cm, weight 4 kg) died of cerebral edema secondary to Escherichia coli meningitis and bacteremia. Preretrieval assessment included the following: arterial gases; pO 50. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.13419
Publisher Site
http://dx.doi.org/10.1111/petr.13419DOI Listing
April 2019
1 Read

Clinical Reasoning: A 71-year-old man receiving treatment for cryptococcal meningitis, developing new-onset lethargy.

Neurology 2019 Apr;92(17):815-820

From the Department of Neurology (T.J.P., T.K., B.D.T.), Yale University School of Medicine, New Haven, CT; and Neurology Service (B.D.T.), VA Connecticut Healthcare System, West Haven.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000007379DOI Listing
April 2019
8.286 Impact Factor

Pemetrexed in the Treatment of Leptomeningeal Metastasis in Patients With EGFR-mutant Lung Cancer.

Clin Lung Cancer 2019 Mar 29. Epub 2019 Mar 29.

Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea; Seoul National University Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

Introduction: Leptomeningeal metastasis (LM), still an area of unmet need, has frequently been observed in patients with EGFR-mutant non-small-cell lung cancer (NSCLC). Because the antitumor efficacy of systemic cytotoxic agents against LM is unclear, we explored the role of pemetrexed in the treatment of patients with LM from EGFR-mutant NSCLC.

Patients And Methods: We retrospectively reviewed the medical records of patients with LM from EGFR-mutant NSCLC treated between 2006 and 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cllc.2019.03.005DOI Listing

Evaluation of Phage Therapy in the Context of and Its Associated Diseases.

Viruses 2019 Apr 20;11(4). Epub 2019 Apr 20.

APC Microbiome Ireland, University College Cork, Cork T12 YT20, Ireland.

Bacteriophages (phages) or bacterial viruses have been proposed as natural antimicrobial agents to fight against antibiotic-resistant bacteria associated with human infections. is a gut commensal, which is occasionally found in the mouth and vaginal tract, and does not usually cause clinical problems. However, it can spread to other areas of the body and cause life-threatening infections, such as septicemia, endocarditis, or meningitis, in immunocompromised hosts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v11040366DOI Listing

Fever and Seizure in a Young Infant: A Simulation Case.

MedEdPORTAL 2016 Sep 28;12:10468. Epub 2016 Sep 28.

Professor of Pediatrics, University of Vermont College of Medicine.

Introduction: Fever in early infancy is a common problem for which management can be challenging. All residents need to be able to recognize critical illness such as meningitis in febrile infants and manage complications such as seizures. Many new residents are not competent performing bedside procedures as there is little opportunity to perform them while in medical school. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15766/mep_2374-8265.10468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464472PMC
September 2016

Talk to Patients About: Pneumococcal Disease.

Authors:
Sean Price

Tex Med 2018 Jun 1;114(6):48. Epub 2018 Jun 1.

Your patients might not have heard of pneumococcal bacteria, but they probably know some of its serious conditions: Pneumonia, meningitis, sinusitis, blood infections, and ear infections. Read More

View Article

Download full-text PDF

Source

Disseminated Strongyloidiasis: Breaking Brain Barriers.

Ann Indian Acad Neurol 2019 Apr-Jun;22(2):234-237

Department of Infectious Diseases, Wayne State School of Medicine, Detroit, Michigan, USA.

(SS) is one of the most overlooked helminthic infections despite being highly endemic in tropical and subtropical areas. In immunocompromised patients, especially those on long-term steroids, infection can often escalate to fatal dissemination into major organs. We present a compendium of two immunocompromised patients, who were on high-dose steroids and presented with worsening neurological status. Read More

View Article

Download full-text PDF

Source
http://www.annalsofian.org/preprintarticle.asp?id=249718
Publisher Site
http://dx.doi.org/10.4103/aian.AIAN_321_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472231PMC
April 2019
4 Reads

Immunodeficiency, Motor Delay, and Hypouricemia Caused by a Novel Mutation of Purine Nucleoside Phosphorylase Gene in an Indian Infant.

Ann Indian Acad Neurol 2019 Apr-Jun;22(2):231-233

Department of Clinical Genetics, MedGenome Laboratory, Bengaluru, Karnataka, India.

We describe an 11-month-old boy who presented with recurrent respiratory infections from 6 months of age. His elder sister died at 10 months with severe septicemia and meningitis. The boy had a mild motor delay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/aian.AIAN_430_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472228PMC

Scrub Typhus-Associated Opsoclonus: Clinical Course and Longitudinal Outcomes in an Indian Cohort.

Ann Indian Acad Neurol 2019 Apr-Jun;22(2):153-158

Department of Infectious Diseases, Christian Medical College Hospital, Vellore, Tamil Nadu, India.

Context: Opsoclonus, a rare neurological manifestation in scrub typhus, causes significant distress and disability. There is a paucity of clinical data and outcomes in these patients.

Aim: This study aims to describe the clinical and laboratory profile and longitudinal outcomes in a scrub typhus patient cohort with opsoclonus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/aian.AIAN_198_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472253PMC

Factors associated with serious bacterial infections in infants ≤60 days with hypothermia in the emergency department.

Am J Emerg Med 2019 Apr 11. Epub 2019 Apr 11.

Division of Infectious Disease, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.

Background: We sought to investigate risk factors for serious bacterial infection (SBI: bacterial meningitis, bacteremia, and urinary tract infection [UTI]) among infants ≤60 days of age presenting to the emergency department (ED) with hypothermia (temperature < 36 °C).

Methods: We performed a single center study over a 12-year period including all patients ≤60 days old with hypothermia, excluding patients who did not receive a blood culture and patients who received antibiotics prior to culture acquisition. The primary outcome was SBI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajem.2019.04.015DOI Listing

[Trends on the epidemics of acute meningitis and encephalitis among population under 18 years-old in Shijiazhuang city, 2007-2017].

Authors:
J H Guo J Li X Zhang

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Apr;40(4):417-421

Hebei Provincial Children Hospital, Shijiazhuang 050030, China.

To understand the trends on the epidemics of acute meningitis and encephalitis (AME) among children under 18 years-old in Shijiazhuang city, 2007-2017. Surveillance programs on acute meningitis and encephalitis (AMES) had been conducted in population less than 18 years-old, since 2007. Hospitals at county level or above in Shijiazhuang had been included to carry out the epidemiologic surveillance, including 6 on pathogens, regarding AMES. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.04.009DOI Listing
April 2019
2 Reads

Deceptively asymptomatic cryptococcaemia in a renal transplant recipient: the lull before a storm.

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Cryptococcal infection constitutes around 3% of opportunistic infections in solid organ transplant recipients. Most common organ affected in renal transplant recipients (RTRs) is central nervous system and usually presents with chronic meningoencephalitis (CME). Ischaemic stroke as a consequence of cryptococcal meningoencephalitisis rare and possibly due to the involvement of intracranial vessel by exudates causing vasculitis-related thrombosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-228115DOI Listing

The clinical characteristics of spontaneous Gram-negative bacterial meningitis in adults: A hospital-based study.

J Clin Neurosci 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

The epidemiologic trend of acute bacterial meningitis can change more dramatically than any other bacterial disease, and a decrease in spontaneous adult bacterial meningitis (ABM) has been noted in serial studies of the epidemiologic trend of ABM in Taiwan. The purpose of this study was to analyze the clinical characteristics, laboratory data and therapeutic outcomes of 149 patients with spontaneous Gram-negative (G(-)) ABM collected during a study period of 31 years (1986-2016). The 149 patients included 107 men and 42 women, aged 18-86 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jocn.2019.03.047DOI Listing

Severe Herpes Zoster Requiring Intravenous Antiviral Treatment in Allogeneic Hematopoietic-cell Transplantation Recipients on Standard Acyclovir Prophylaxis.

Biol Blood Marrow Transplant 2019 Apr 17. Epub 2019 Apr 17.

Brigham and Women's Hospital, Department of Infectious Diseases, Boston, Massachusetts; Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, Massachusetts.

Allogeneic hematopoietic cell transplant (HCT) recipients are at increased risk for varicella zoster virus reactivation and associated complications. The incidence, timing, and risk factors for severe herpes zoster (HZ) are not well described in the era of acyclovir (ACV) prophylaxis. We performed a retrospective cohort study of all patients who underwent first allogeneic HCT from October 2006 to December 2015 at our institution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2019.04.015DOI Listing
April 2019
1 Read

International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact.

EBioMedicine 2019 Apr 16. Epub 2019 Apr 16.

Parasites and microbes, Wellcome Sanger Institute, Hinxton, UK.

Background: Pneumococcal conjugate vaccines have reduced the incidence of invasive pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a concern. We used whole genome sequencing to study pneumococcal serotype, antibiotic resistance and invasiveness, in the context of genetic background.

Methods: Our dataset of 13,454 genomes, combined with four published genomic datasets, represented Africa (40%), Asia (25%), Europe (19%), North America (12%), and South America (5%). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S23523964193025
Publisher Site
http://dx.doi.org/10.1016/j.ebiom.2019.04.021DOI Listing
April 2019
1 Read

Murine typhus Presenting with Status Epilepticus.

Int J Infect Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of General Medicine, Changi General Hospital, 2 Simei Street 3, 529889 Singapore.

Patients with rickettsial infection usually present with a febrile illness, headache, arthromyalgia and various biochemical abnormalities. Neurologic involvement is rare in murine typhus. Here, we report a case of a patient who presented with status epilepticus secondary to Rickettsia typhi infection. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S12019712193018
Publisher Site
http://dx.doi.org/10.1016/j.ijid.2019.04.012DOI Listing
April 2019
1 Read

Fatal Meningitis in Patient with X-Linked Chronic Granulomatous Disease Caused by Virulent Granulibacter bethesdensis.

Emerg Infect Dis 2019 May;25(5):976-979

Granulibacter bethesdensis is a pathogen reported to cause recurrent lymphadenitis exclusively in persons with chronic granulomatous disease. We report a case of fatal meningitis caused by a highly virulent G. bethesdensis strain in an adolescent in Europe who had chronic granulomatous disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3201/eid2505.181505DOI Listing

Neonatal Conjunctivitis Caused by Neisseria meningitidis US Urethritis Clade, New York, USA, August 2017.

Emerg Infect Dis 2019 May;25(5):972-975

We characterized a case of neonatal conjunctivitis in New York, USA, caused by Neisseria meningitidis by using whole-genome sequencing. The case was a rare occurrence, and the isolate obtained belonged to an emerging clade (N. meningitidis US nongroupable urethritis) associated with an increase in cases of urethritis since 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3201/eid2505.181631DOI Listing

Meningeal enhancement depicted by magnetic resonance imaging in tumor patients: neoplastic meningitis or therapy-related enhancement?

Neuroradiology 2019 Apr 18. Epub 2019 Apr 18.

Diagnostic and Interventional Neuroradiology, Eberhard Karls University Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.

Purpose: To assess the prevalence of false-positive meningeal contrast enhancement in patients with solid tumors who were undergoing chemotherapy.

Methods: A total of 2572 magnetic resonance imaging (MRI) examinations of the brain were retrospectively evaluated by two readers for the presence of pathological meningeal contrast enhancement conspicuous for neoplastic meningitis. These patients either had malignant melanoma, breast or lung cancer, or lymphoma. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00234-019-02215-y
Publisher Site
http://dx.doi.org/10.1007/s00234-019-02215-yDOI Listing
April 2019
2 Reads

Immediate Neutrophil-Variable-T Cell Receptor Host Response in Bacterial Meningitis.

Front Neurol 2019 2;10:307. Epub 2019 Apr 2.

Bioscientia Institute for Medical Diagnostics, Ingelheim, Germany.

Bacterial meningitis is a life-threatening disease that evokes an intense neutrophil-dominated host response to microbes invading the subarachnoid space. Recent evidence indicates the existence of combinatorial V(D)J immune receptors in neutrophils that are based on the T cell receptor (TCR). Here, we investigated expression of the novel neutrophil TCRαβ-based V(D)J receptors in cerebrospinal fluid (CSF) from human patients with acute-phase bacterial meningitis using immunocytochemical, genetic immunoprofiling, cell biological, and mass spectrometric techniques. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fneur.2019.00307
Publisher Site
http://dx.doi.org/10.3389/fneur.2019.00307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454057PMC
April 2019
1 Read

Ventriculoperitoneal Shunt Disconnection, Shunt Migration, and Silent Bowel Perforation in a 10-Year-Old Boy.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):342-345

Department of Pediatric Surgery, Gandhi Medical College and Associated, Kamla Nehru and Hamidia Hospitals, Bhopal, Madhya Pradesh, India.

A 10-year-old boy was admitted with chest wall infection around the implanted ventriculoperitoneal shunt (VPS) catheter of 5 days. He had received a right-sided, medium pressure, whole-length VPS for hydrocephalus, following tubercular meningitis at the age of 3 years. Seven years, 9 months following VPS implantation, he was admitted with shunt tract infection at the chest area for 5 days. Read More

View Article

Download full-text PDF

Source
http://www.ruralneuropractice.com/text.asp?2019/10/2/342/254
Publisher Site
http://dx.doi.org/10.4103/jnrp.jnrp_329_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454935PMC
April 2019
1 Read

Invasive Salmonella infections among children in Bintulu, Sarawak, Malaysian Borneo: a 6-year retrospective review.

BMC Infect Dis 2019 Apr 18;19(1):330. Epub 2019 Apr 18.

Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia.

Background: Invasive Salmonella infections result in significant morbidity and mortality in developing countries. In Asia, typhoid and paratyphoid fever are reported to be the major invasive Salmonella infections, while invasive non-typhoidal Salmonella (iNTS) infections are believed to be uncommon. Data from Sarawak, in Malaysian Borneo, are limited. Read More

View Article

Download full-text PDF

Source
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12879-019-3963-xDOI Listing
April 2019
1 Read
2.613 Impact Factor

Radiographic and histological evidence of metabolic bone disease in gliding leaf frogs ().

Heliyon 2019 Apr 5;5(4):e01432. Epub 2019 Apr 5.

Escuela de Medicina Veterinaria, Facultad de Ciencias de la Salud, Universidad de Las Américas, Colimes y Granados 170513, Ecuador.

Bone alterations due to metabolic bone disease in captive animal populations can have a negative impact on repopulation and research initiatives. This investigation has the purpose of describing the principal radiographic and anatomopathological findings present in nine gliding leaf frogs () kept in captivity with alterations in their spines and long bones. The observed histopathological findings were in the canalis vertebralis, paraspinal muscle and long bones, and included deformed bones with alteration of the adjacent tissues, alterations in the ossification process, bone degeneration and resorption, decreased number of osteocytes and deposition of osteoid and fibrous material in the compact bone tissue. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S24058440183305
Publisher Site
http://dx.doi.org/10.1016/j.heliyon.2019.e01432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451164PMC
April 2019
1 Read

Population-based study of early-onset neonatal sepsis in Canada.

Paediatr Child Health 2019 May 24;24(2):e66-e73. Epub 2018 Apr 24.

Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario.

Objective: To determine the incidence, types of organisms and resistance patterns involved in early-onset neonatal sepsis in Canada.

Study Design: Early-onset neonatal sepsis cases were identified through the Canadian Paediatric Surveillance Program. Neonates were excluded if they were asymptomatic or if intracranial procedures preceded a positive cerebrospinal fluid culture. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/pch/article/24/2/e66/4983126
Publisher Site
http://dx.doi.org/10.1093/pch/pxy018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462127PMC
May 2019
1 Read

Assessing the causes of under-five mortality and proportion associated with pneumococcal diseases in Cameroon. A case-finding retrospective observational study: 2006-2012.

PLoS One 2019 17;14(4):e0212939. Epub 2019 Apr 17.

Mother & Child Centre (MCH), Chantal Biya Foundation, Yaoundé, Cameroon.

Background: Vital registration data outlining causes of deaths (CoD) are important for a sustainable health system, targeted interventions and other relevant policies. There is data paucity on vital registration systems in developing countries. We assessed the leading causes and proportions of under-five deaths, and particularly those related to pneumococcal infections in Yaoundé, Cameroon, using hospital registration data. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212939PLOS
April 2019
1 Read

Primary Petrous Apex Epidermoids With Skull Base Erosion.

Otol Neurotol 2019 Apr 10. Epub 2019 Apr 10.

Division of Otolaryngology - Head and Neck Surgery, University of Utah, Salt Lake City, Utah.

Objective: To describe the clinical course and treatment outcomes for patients with petrous apex epidermoid with skull base erosion.

Study Design: Retrospective case series.

Setting: Tertiary-care academic center. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MAO.0000000000002199DOI Listing
April 2019
1 Read

Inadequate diagnostics: the case to move beyond the bacilli for detection of meningitis due to Mycobacterium tuberculosis.

J Med Microbiol 2019 Apr 17. Epub 2019 Apr 17.

3 University of Minnesota, Minneapolis, MN, USA.

Tuberculosis (TB) meningitis is extremely difficult to diagnose due to its pauci-bacillary disease nature and new techniques are needed. Improved test sensitivity would allow for greater clinician confidence in diagnostic testing and has the potential to improve patient outcomes. Traditional microbiologic and molecular tests for TB meningitis focus on detection of TB bacilli and are inadequate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/jmm.0.000975DOI Listing
April 2019
1 Read

Acute Community-Acquired Bacterial Meningitis: Update on Clinical Presentation and Prognostic factors.

New Microbiol 2019 Apr 17;41(2). Epub 2019 Apr 17.

Department of Infectious Diseases, Hospital Fundación Jiménez-Díaz, Universidad Autonoma, Madrid, Spain.

The epidemiology of community-acquired bacterial meningitis (CABM) in adults has changed significantly in the past several years. Despite substantial improvement in patient care, CABM remains a major cause of morbidity and mortality. Thus, new prognostic factors could help improve patient stratification. Read More

View Article

Download full-text PDF

Source
April 2019
1 Read

Laboratory validation of a clinical metagenomic sequencing assay for pathogen detection in cerebrospinal fluid.

Genome Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California 94143, USA.

Metagenomic next-generation sequencing (mNGS) for pan-pathogen detection has been successfully tested in proof-of-concept case studies in patients with acute illness of unknown etiology but to date has been largely confined to research settings. Here, we developed and validated a clinical mNGS assay for diagnosis of infectious causes of meningitis and encephalitis from cerebrospinal fluid (CSF) in a licensed microbiology laboratory. A customized bioinformatics pipeline, SURPI+, was developed to rapidly analyze mNGS data, generate an automated summary of detected pathogens, and provide a graphical user interface for evaluating and interpreting results. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gr.238170.118DOI Listing

Prevalence of group B streptococcus among pregnant women and newborns at Hawassa University comprehensive specialized hospital, Hawassa, Ethiopia.

BMC Infect Dis 2019 Apr 16;19(1):325. Epub 2019 Apr 16.

Department of Pediatrics, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.

Background: Group B streptococcus (GBS) is reported as the leading cause of neonatal sepsis and meningitis. Newborns from GBS colonized pregnant women are at high risk of infection.

Method: A Hospital based cross-sectional study was conducted at Hawassa University Comprehensive Specialized Hospital from November 05, 2014 to March 25, 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-019-3859-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469063PMC

Fosfomycin: the characteristics, activity, and use in critical care.

Ther Clin Risk Manag 2019 27;15:525-530. Epub 2019 Mar 27.

Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran,

Fosfomycin (CHOP) is a phosphonic acid derivative representing an epoxide class of antibiotics. The drug is a re-emerging bactericidal antibiotic with a wide range of actions against several Gram-positive and Gram-negative bacteria. Among the existing antibacterial agents, fosfomycin has the lowest molecular weight (138 Da), which is not structurally associated with other classes of antibiotics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/TCRM.S199119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441553PMC
March 2019
4 Reads

Structural switching electrochemical DNA aptasensor for the rapid diagnosis of tuberculous meningitis.

Int J Nanomedicine 2019 26;14:2103-2113. Epub 2019 Mar 26.

AptaBharat Innovation Pvt. Ltd., Faridabad, India,

Background: Tuberculous meningitis (TBM) is the most devastating manifestation of extra-pulmonary tuberculosis. About 33% of TBM patients die due to very late diagnosis of the disease. Conventional diagnostic methods based on signs and symptoms, cerebrospinal fluid (CSF) smear microscopy or liquid culture suffer from either poor sensitivity or long turnaround time (up to 8 weeks). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IJN.S189127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440448PMC
March 2019
2 Reads

Case fatality rates of invasive meningococcal disease by serogroup and age: A systematic review and meta-analysis.

Vaccine 2019 Apr 13. Epub 2019 Apr 13.

The University of Adelaide, Adelaide Medical School, Adelaide, South Australia, Australia; The University of Adelaide, The Robinson Research Institute, Adelaide, South Australia, Australia; The University of Adelaide, School of Public Health, Adelaide, South Australia, Australia; Vaccinology and Immunology Research Trials Unit (VIRTU), Women's and Children's Hospital, Adelaide, South Australia, Australia. Electronic address:

Introduction: Invasive meningococcal disease (IMD) is uncommon but still causes considerable public health burden due to its high mortality and morbidity. This review aims to quantitatively synthesise all published evidence pertinent to mortality caused by IMD and assess the effect of age and serogroup on case fatality rates (CFRs).

Methods: The PubMed and Embase databases, and the Cochrane Library were searched. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vaccine.2019.04.020DOI Listing
April 2019
1 Read