81,020 results match your criteria Meningitis


BACTERIAL MENINGITIS IN PATIENTS WITH MULTIPLE MYELOMA: A PROSPECTIVE NATIONWIDE COHORT STUDY AND REVIEW OF THE LITERATURE.

Int J Infect Dis 2022 Jun 24. Epub 2022 Jun 24.

Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

Objective: To study the clinical features of bacterial meningitis in myeloma patients.

Methods: We analyzed myeloma patients included in a nationwide cohort of patients >16 years old with community-acquired bacterial meningitis in the Netherlands between 2006 and 2018. Subsequently, we reviewed the literature for articles reporting myeloma patients with bacterial meningitis. Read More

View Article and Full-Text PDF

Caution when using 1,3, β-D-glucan in the CSF as a biomarker of Candida albicans meningitis.

Int J Infect Dis 2022 Jun 24. Epub 2022 Jun 24.

Bacteriology Laboratory, Dept of Diagnostics, Geneva University Hospitals, Geneva, Switzerland; Infectious Diseases Division, Dept of Medicine, Geneva University Hospitals, Geneva, Switzerland.

Relying on a biomarker to diagnose or follow-up the treatment of a Candida albicans meningitis would have an impact on patient management. The biomarker 1,3, β-D-glucan (BDG), developed for serum testing, shows inconsistent values when applied on cerebro-spinal fluid (CSF), and its use with the current protocol on CSF samples warrants caution. Read More

View Article and Full-Text PDF

Establishment of an astrocyte-like cell line from the brain of tilapia (Oreochromis niloticus) for virus pathogenesis and a vitro model of the blood-brain barrier.

J Fish Dis 2022 Jun 27. Epub 2022 Jun 27.

Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy culture, Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, College of Fishery, Guangdong Ocean University, Zhanjiang, P. R. China.

A new cell line was established from the brain of a cultured fish, tilapia (Oreochromis niloticus), designated as TA-02 (Tilapia Astrocyte clone 02 cell line). The TA-02 cells are grown for 300 days in an L-15 medium supplemented with 10% fetal bovine serum (FBS). This cell line showed excellent proliferative capacity and expressed various neuroglial cell markers, including SOX2, SOX10, Hes1, Notch1, Occludin, E-cadherin, and GFAP. Read More

View Article and Full-Text PDF

Extra-pulmonary applications of procalcitonin: .

Expert Rev Mol Diagn 2022 Jun 27. Epub 2022 Jun 27.

Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.

Introduction: : Procalcitonin (PCT) is a biomarker with established performance in the differentiation between bacterial and viral infections, predominantly in pulmonary infections, as well as the diagnosis and prognosis of bacterial sepsis. However, the role of PCT in extra-pulmonary infections is not well described.

Areas Covered: : We reviewed the role of PCT in commonly experienced extra-pulmonary infections including meningitis, diabetic foot infection, prosthetic joint infection, osteomyelitis, and skin and soft tissue infection. Read More

View Article and Full-Text PDF

Updated estimated incidence and prevalence of serious fungal infections in Trinidad and Tobago.

IJID Reg 2021 Dec 27;1:34-40. Epub 2021 Sep 27.

Manchester Fungal Infection Group, The University of Manchester and Manchester Academic Health Science Centre, Manchester, UK.

Objective: : To estimate the incidence and prevalence of serious fungal infections in Trinidad and Tobago (T&T), with a population of 1 394 973 million.

Methods: : The medical literature was searched to obtain published data on the incidence and prevalence of fungal infections in the Caribbean. If data were unavailable, estimations were performed using the frequencies of fungal infection in populations at risk. Read More

View Article and Full-Text PDF
December 2021

The epidemiology of meningococcal meningitis: multicenter, hospital-based surveillance of meningococcal meningitis in Iraq.

IJID Reg 2021 Dec 28;1:100-106. Epub 2021 Oct 28.

Ministry of Health, Baghdad, Iraq.

Objectives: Outbreaks of have reached alarming levels due to the pathogen's ability to cause severe complications, presenting as meningitis or septicemia. Our study reports the results of the first wide-scale surveillance of meningococcal meningitis in Iraq.

Methods: The study included all consecutive cases of clinically suspected meningitis between June 2018 and May 2020 at 18 major hospitals around Iraq ( = 2314). Read More

View Article and Full-Text PDF
December 2021

aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases.

Front Oral Health 2022 10;3:897115. Epub 2022 Jun 10.

Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

The manuscript uses the previously published literature and highlights the benefits of active-matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as adjunctive measures in oral and systemic diseases. Previous studies suggest that as a biomarker, aMMP-8 is more precise than total MMP-8, MMP-9, MMP-2, MMP-3, MMP-13, MMP-7, MMP-1, calprotectin, myeloperoxidase (MPO), human neutrophil elastase (HNE), tissue inhibitor of matrix metalloproteinase (TIMP)-1, and bleeding of probing (BOP). Therefore, aMMP-8 could be implemented as the needed key biomarker for the new disease classification for both periodontitis and peri-implantitis. Read More

View Article and Full-Text PDF

Emerging Antibiotic Resistance Patterns in a Neonatal Intensive Care Unit in Pune, India: A 2-Year Retrospective Study.

Front Pediatr 2022 10;10:864115. Epub 2022 Jun 10.

Division of Neonatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Objective: Treating neonatal bloodstream infections and meningitis in South Asia remains difficult given high rates of antimicrobial resistance (AMR). To evaluate changing epidemiology of neonatal infections, we assessed pathogen-specific and clinical features of culture-proven infections in neonates admitted to a neonatal intensive care unit (NICU) in Pune, India.

Materials And Methods: This retrospective cohort study was performed in the King Edward Memorial Hospital and Research Center NICU over 2 years between January 1, 2017 and December 31, 2018. Read More

View Article and Full-Text PDF

Bilateral Cerebral Mucormycosis in an Immunocompetent Female.

Ochsner J 2022 ;22(2):169-175

Department of Neurocritical Care, Ochsner Clinic Foundation, New Orleans, LA.

Mucormycosis is a serious angioinvasive fungal infection. Immunocompromised patients are more likely to be susceptible to mucormycosis than immunocompetent individuals. Cerebral mucormycosis has been reported, but cases have primarily been unilateral. Read More

View Article and Full-Text PDF
January 2022

Epidemiology and Clinical Features of Listeriosis in Gipuzkoa, Spain, 2010-2020.

Front Microbiol 2022 9;13:894334. Epub 2022 Jun 9.

Department of Preventive Medicine, University of the Basque Country (UPV/EHU), San Sebastián, Spain.

Background: Listeriosis continues to be one of the most important notifiable foodborne diseases. Nonetheless, in Spain, there are few data on the molecular epidemiology of infections in recent years.

Aim: To describe clinical features and the molecular epidemiology of human listeriosis over an 11-year period (2010-2020) in Gipuzkoa, Northern Spain. Read More

View Article and Full-Text PDF

Dynamic Python-Based Method Provides Quantitative Analysis of Intercellular Junction Organization During Infection of the Respiratory Epithelium.

Front Cell Infect Microbiol 2022 10;12:865528. Epub 2022 Jun 10.

Department of Biological Sciences, San Jose State University, San Jose, CA, United States.

Many respiratory pathogens compromise epithelial barrier function during lung infection by disrupting intercellular junctions, such as adherens junctions and tight junctions, that maintain intercellular integrity. This includes , a leading cause of pneumonia, which can successfully breach the epithelial barrier and cause severe infections such as septicemia and meningitis. Fluorescence microscopy analysis on intercellular junction protein manipulation by respiratory pathogens has yielded major advances in our understanding of their pathogenesis. Read More

View Article and Full-Text PDF

Pseudo Subarachnoid Hemorrhage Sign in Bacterial Meningitis in a Patient Presenting With Acute Ischemic Stroke: A Novel Radiological Clue to Rapid Diagnosis.

Cureus 2022 May 24;14(5):e25283. Epub 2022 May 24.

Neuroradiology, Prisma Health Greenville Memorial Hospital, Greenville, USA.

Pseudo subarachnoid hemorrhage (SAH) is an entity defined when characteristic computed tomography (CT) findings of SAH are seen without evidence of hemorrhage on MRI, autopsy, or cerebrospinal fluid analysis. This imaging phenomenon has been reported in association with multiple clinical settings including diffuse cerebral edema, hypoxic-ischemic injury, post percutaneous coronary intervention, and the focus of our report, acute bacterial meningitis. The mechanisms leading to this finding are poorly understood. Read More

View Article and Full-Text PDF

Medical Mycology dissertation topics require prioritisation among Postgraduate Microbiology trainees of Makerere University, Uganda.

IJID Reg 2022 Jun 4;3:261-264. Epub 2022 May 4.

Department of Medical Microbiology & Immunology, Faculty of Medicine, Gulu University, Gulu, Uganda.

Background: As elsewhere worldwide, there is an increasing burden of fungal diseases in Uganda. However, expertise in medical mycology (the study of fungal diseases of medical importance) among clinicians and laboratory personnel remains low.

Objective: This study sought to determine the proportion of dissertations on medical mycology among postgraduate medical microbiology trainees at the College of Health Sciences, Makerere University, Uganda. Read More

View Article and Full-Text PDF

An Overview of La Crosse Virus Disease.

Neurohospitalist 2022 Jul 28;12(3):587-588. Epub 2022 Feb 28.

Department of Neurology and Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, CO, USA.

View Article and Full-Text PDF

Reduced CSF orexin levels in rats and patients with systemic inflammation: a preliminary study.

BMC Res Notes 2022 Jun 25;15(1):221. Epub 2022 Jun 25.

Department of Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Objective: Sepsis is a lethal condition characterized by systemic inflammation and multiple organ failure; this condition was initially defined as systemic inflammatory response syndrome (SIRS) due to infection. We previously reported that the hypothalamic neuropeptide orexin improved survival in a murine model of sepsis by mainly acting in the medullary raphe nucleus through orexin type-2 receptors. We hypothesized that orexin treatment enhances recovery from sepsis by reversing the reduction in orexin levels in the cerebrospinal fluid (CSF). Read More

View Article and Full-Text PDF

Vaccine-Strain Varicella Virus Transmitted to a Term Infant Following Maternal Postpartum Vaccination.

J Pediatric Infect Dis Soc 2022 Jun 25. Epub 2022 Jun 25.

Department of Pediatrics, John A. Burns School of Medicine, University of Hawai'i, Honolulu, Hawaii, USA.

Varicella is a highly contagious disease caused by Varicella-zoster virus (VZV). The American College of Obstetricians and Gynecologists (ACOG) adopted the routine administration of varicella vaccine to varicella non-immune mothers postpartum before leaving the facility per the Advisory Committee in Immunization Practices (ACIP) recommendation of Varicella prevention. While the vaccine is well-tolerated, a live attenuated vaccine has the potential to cause clinical symptoms and complications, including rash. Read More

View Article and Full-Text PDF

Access to flucytosine for the treatment of HIV-associated cryptococcal meningitis in Africa.

Lancet Infect Dis 2022 Jun 21. Epub 2022 Jun 21.

Molecular Mycology Unit, Institut Pasteur of Paris, Paris, France; Department of Infectious and Tropical Diseases, University of Paris Cité, Paris, France; Department of Infectious and Tropical Diseases, Necker Hospital, Paris, France.

View Article and Full-Text PDF

Outcomes of flucytosine-containing combination treatment for cryptococcal meningitis in a South African national access programme: a cross-sectional observational study.

Lancet Infect Dis 2022 Jun 21. Epub 2022 Jun 21.

Centre for Healthcare-Associated Infections, Antimicrobial Resistance and Mycoses, National Institute for Communicable Diseases, a Division of the National Health Laboratory Service, Johannesburg, South Africa; School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Institute of Infection and Immunity, St George's University of London, London, UK; MRC Centre for Medical Mycology, University of Exeter, Exeter, UK; Division of Medical Microbiology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Background: Although flucytosine is a key component of WHO-recommended induction treatment for HIV-associated cryptococcal meningitis, this antifungal agent is not widely available in low-income and middle-income countries due to limited production and cost. In 2018, a national flucytosine access programme was initiated in South Africa. We aimed to determine the effectiveness of flucytosine-containing induction regimens in routine care to motivate for the urgent registration of flucytosine and its inclusion in treatment guidelines. Read More

View Article and Full-Text PDF

Long term outcomes of patients with tuberculous meningitis: The impact of drug resistance.

PLoS One 2022 24;17(6):e0270201. Epub 2022 Jun 24.

Emory University School of Medicine, Atlanta, Georgia, United States of America.

Background: Little is known about the impact of drug-resistance on clinical outcomes among patients with tuberculosis meningitis (TBM).

Methods: A retrospective cohort study among patients treated for TBM in Tbilisi, Georgia. We performed medical chart abstraction to collect patient data. Read More

View Article and Full-Text PDF

MRI-based radiomics signature for identification of invisible basal cisterns changes in tuberculous meningitis: a preliminary multicenter study.

Eur Radiol 2022 Jun 24. Epub 2022 Jun 24.

Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Objective: To develop and evaluate a radiomics signature based on magnetic resonance imaging (MRI) from multicenter datasets for identification of invisible basal cisterns changes in tuberculous meningitis (TBM) patients.

Methods: Our retrospective study enrolled 184 TBM patients and 187 non-TBM controls from 3 Chinese hospitals (training dataset, 158 TBM patients and 159 non-TBM controls; testing dataset, 26 TBM patients and 28 non-TBM controls). nnU-Net was used to segment basal cisterns in fluid-attenuated inversion recovery (FLAIR) images. Read More

View Article and Full-Text PDF

Pembrolizumab-induced aseptic meningitis in a patient with non-small cell lung cancer: A case report and literature review of aseptic meningitis as an immune-related adverse event.

Mol Clin Oncol 2022 Jul 1;17(1):120. Epub 2022 Jun 1.

Department of Multidisciplinary Internal Medicine, Division of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.

Aseptic meningitis is a rare immune-related adverse event (irAE), which occurs during treatment with immune checkpoint inhibitors (ICIs). This condition has non-specific symptoms and exhibits no clear signs on magnetic resonance imaging (MRI). There are only a few reports of aseptic meningitis caused by pembrolizumab treatment for non-small cell lung cancer (NSCLC). Read More

View Article and Full-Text PDF

Clinical presentation and short-term outcomes of multisystemic inflammatory syndrome in children in Lagos, Nigeria during the COVID-19 pandemic: A case series.

EClinicalMedicine 2022 Jul 27;49:101475. Epub 2022 May 27.

Department of Paediatrics, College of Medicine, University of Lagos, Lagos, Nigeria.

Background: Multisystemic inflammatory syndrome in children (MIS-C) has increasingly been documented globally with the progression of the COVID-19 pandemic and a significant proportion of cases have been noted in children of Black descent. There has been a noticeable discrepancy in the presentation and outcomes of COVID-19 infection in sub-Saharan Africa compared to the rest of the world. We documented the demography, clinical features, laboratory and imaging findings, therapeutic management, and short-term outcomes of paediatric patients with MIS-C diagnosed during the COVID-19 pandemic in Lagos, Nigeria. Read More

View Article and Full-Text PDF

Neurodevelopmental and growth outcomes after invasive Group B in early infancy: A multi-country matched cohort study in South Africa, Mozambique, India, Kenya, and Argentina.

EClinicalMedicine 2022 May 28;47:101358. Epub 2022 Apr 28.

Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Background: Data are limited regarding long-term consequences of invasive GBS (iGBS) disease in early infancy, especially from low- and middle-income countries (LMIC) where most cases occur. We aimed to estimate risk of neurodevelopmental impairment (NDI) in children with a history of iGBS disease.

Methods: A multi-country matched cohort study was undertaken in South Africa, India, Mozambique, Kenya, and Argentina from October 2019 to April 2021. Read More

View Article and Full-Text PDF

Molnupiravir and Its Active Form, EIDD-1931, Show Potent Antiviral Activity against Enterovirus Infections In Vitro and In Vivo.

Viruses 2022 May 25;14(6). Epub 2022 May 25.

National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

Enterovirus infections can cause hand, foot, and mouth disease (HFDM), aseptic meningitis, encephalitis, myocarditis, and acute flaccid myelitis, leading to death of infants and young children. However, no specific antiviral drug is currently available for the treatment of this type of infection. The Unites States and United Kingdom health authorities recently approved a new antiviral drug, molnupiravir, for the treatment of COVID-19. Read More

View Article and Full-Text PDF

Public Health Value of a Hypothetical Pneumococcal Conjugate Vaccine (PCV) Introduction: A Case Study.

Vaccines (Basel) 2022 Jun 15;10(6). Epub 2022 Jun 15.

Policy and Economic Research Department, International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, Gwanak-gu, Seoul 8826, Korea.

Background: Understanding the public health value of a vaccine at an early stage of development helps in valuing and prioritizing the investment needed. Here we present the potential cost-effectiveness of an upcoming 12 valent pneumococcal conjugate vaccine (PCV 12) in the case study country, Thailand.

Methods: The cost-effectiveness analysis included a hypothetical scenario of three doses (2 + 1 regimen) PCV12 introduction in the national immunization program of Thailand compared to no PCV, PCV10, and PCV13 among <6 months old from a societal perspective with a lifetime horizon and one-year cycle length. Read More

View Article and Full-Text PDF

Cryptococcal Meningitis in Kidney Transplant Recipients: A Two-Decade Cohort Study in France.

Pathogens 2022 Jun 17;11(6). Epub 2022 Jun 17.

Centre de Recherche Saint-Antoine, CRSA, Inserm, AP-HP, Hôpital Saint-Antoine, Service de Parasitologie-Mycologie, Sorbonne Université, 75012 Paris, France.

Cryptococcosis is the third most common cause of invasive fungal infection in solid organ transplant recipients and cryptococcal meningitis (CM) its main clinical presentation. CM outcomes, as well as its clinical features and radiological characteristics, have not yet been considered on a large scale in the context of kidney transplantation (KT). We performed a nationwide retrospective study of adult patients diagnosed with cryptococcosis after KT between 2002 and 2020 across 30 clinical centers in France. Read More

View Article and Full-Text PDF

The Ability of Nuclease-Resistant RNA Aptamer against Serotype 2, Strain P1/7 to Reduce Biofilm Formation In Vitro.

Molecules 2022 Jun 17;27(12). Epub 2022 Jun 17.

Division of Clinical Microbiology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.

, a Gram-positive bacterium, is an important swine and human pathogen, with serotype 2 being the most prevalent strain found worldwide. Deafness, meningitis, and death (in severe cases) are observed in -infected cases. Development of the ligands that can bind to with high affinity and specificity could be beneficial for the diagnosis and treatment of infection. Read More

View Article and Full-Text PDF

Clinical Infections, Antibiotic Resistance, and Pathogenesis of .

Microorganisms 2022 May 31;10(6). Epub 2022 May 31.

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt.

) constitutes the main part of the human skin microbiota. It is widespread in hospitals and among medical staff, resulting in being an emerging microbe causing nosocomial infections. , especially strains that cause nosocomial infections, are more resistant to antibiotics than other coagulase-negative Staphylococci. Read More

View Article and Full-Text PDF

Diagnostic Value of Radioisotope Cisternography Using In-DTPA in a Patient with Rhinorrhea and Purulent Meningitis.

Medicina (Kaunas) 2022 May 26;58(6). Epub 2022 May 26.

The Department of Infectious Diseases and Travel Medicine, Louis Pasteur University Hospital, Rastislavova 43, 04011 Kosice, Slovakia.

Cerebrospinal fluid (CSF) leakage is a rare condition. Prompt diagnosis and early treatment of CSF leakage minimizes the risk of severe complications such as bacterial meningitis. Different diagnostic modalities are used to detect the site of CSF leakage but often with unreliable results. Read More

View Article and Full-Text PDF