78,434 results match your criteria Meningitis


Microbial aspects and potential markers for differentiation between bacterial and viral meningitis among adult patients.

PLoS One 2021 11;16(6):e0251518. Epub 2021 Jun 11.

Department of Microbiology and Immunology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.

Objectives: Meningitis is a medical emergency with permanent disabilities and high mortality worldwide. We aimed to determine causative microorganisms and potential markers for differentiation between bacterial and viral meningitis.

Methodology: Adult patients with acute meningitis were subjected to lumber puncture. Read More

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Clinical Manifestations and Long-Term Outcome of Early Lyme Neuroborreliosis According to EFNS Diagnostic Criteria (Definite versus Possible) in Central Europe. A Retrospective Cohort Study.

Eur J Neurol 2021 Jun 11. Epub 2021 Jun 11.

Institute for Microbiology and Immunology Ljubljana, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1104, Ljubljana, Slovenia.

Background: Characteristics and long-term outcome of Lyme neuroborreliosis (LNB) according to diagnostic certainty (definite versus possible) are incompletely understood.

Methods: In this retrospective cohort study of adults with definite or possible LNB, clinical and microbiologic characteristics and long-term outcome over 12-months were evaluated at a single medical center. Severity of acute disease and long-term outcome were assessed using a composite clinical score encompassing clinical findings and symptoms and by the probability of incomplete recovery. Read More

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in pregnancy and the impact of recommendations on adherence to guidelines: an Italian area-based study.

J Matern Fetal Neonatal Med 2021 Jun 10:1-5. Epub 2021 Jun 10.

Dipartimento Materno-Infantile ASL VCO, Verbania, Italia.

Introduction: Streptococcus agalactiae, a species of β-haemolytic streptococcus belonging to Lancefield's group B (GBS), is known as a common infecting agent transmitted to infants during childbirth, causing sepsis, meningitis, or both, with a high incidence of mortality. Following the observation of a great variability between regional laboratories both in the methodology and in the results of tests for the detection of GBS in pregnancy, with high percentages of false negative results, in 2010 the Department for Health Policies of Piedmont, Italian region, issued specific recommendations for adhere to international guidelines. Our aim was to assess whether the impact of the publication of the recommendations has been lasting over time. Read More

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Differential diagnosis of the association of gastrointestinal symptoms and ST segment elevation, in the absence of chest pain.

Authors:
Oscar M P Jolobe

Am J Emerg Med 2021 Jun 4;49:137-141. Epub 2021 Jun 4.

British Medical Association, Flat 6 Souchay Court, 1 Clothorn Road, Manchester M20 6BR, United Kingdom. Electronic address:

This is a review of the underlying causes of the association of ST segment elevation and gastrointestinal symptoms such as abdominal pain, nausea, vomiting, and anorexia, in patients who do not have chest pain. The review was based on anecdotal reports in Googlescholar and Pubmed using the search terms, abdominal pain, nausea, vomiting, anorexia, ST elevation, myocardial infarction, and Takotsubo cardiomyopathy. Those patients who did not have acute myocardial infarction as the cause of the association of ST segment elevation and gastrointestinal symptoms were compared with counterparts with similar symptoms who had well authenticated acute myocardial infarction or Takotsubo cardiomyopathy as the underlying cause of ST segment elevation. Read More

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Incidence and Distribution of the Pathogens Causing Central Nervous System Infections at the University Hospital of Korea.

Clin Lab 2021 Jun;67(6)

Background: The pathogens involved in central nervous system (CNS) infections are various, such as viruses, bacteria, and fungi, so a syndromic approach can be required. In addition, since their rapid and accurate detection is very crucial, molecular diagnostics using cerebrospinal fluid is becoming the emerging standard method.

Methods: The study was conducted retrospectively to identify the incidence and distribution patterns of the pathogens according to gender, age, season, and month and to analyze their codetection from August 2017 to July 2020. Read More

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Kocuria varians meningitis in a child with chronic granulomatous disease.

Turk Arch Pediatr 2021 1;56(3):278-279. Epub 2021 May 1.

2 Pediatric Clinic, Department of Mother and Child, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Romania; Emergency Clinical Hospital for Children, Cluj-Napoca, Romania.

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Metagenomic Next-Generation Sequencing for Pathogen Detection and Transcriptomic Analysis in Pediatric Central Nervous System Infections.

Open Forum Infect Dis 2021 Jun 6;8(6):ofab104. Epub 2021 Mar 6.

Rady Children's Institute for Genomic Medicine, San Diego, California, USA.

Background: Pediatric central nervous system (CNS) infections are potentially life-threatening and may incur significant morbidity. Identifying a pathogen is important, both in terms of guiding therapeutic management and in characterizing prognosis. Usual care testing by culture and polymerase chain reaction is often unable to identify a pathogen. Read More

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Determining Anterior Fontanel Size and Associated Factors Among Term Neonates on the First Day of Life Born at Jimma University Medical Center (JUMC), Southwest Ethiopia: A Linear Regression Model.

Pediatric Health Med Ther 2021 1;12:269-278. Epub 2021 Jun 1.

School of Medicine, College of Health and Medical Science, Haramaya University, Harar, Ethiopia.

Background: Knowledge of the normal variation in AF size may be helpful to cue early diagnosis of congenital hypothyroidism, hyperthyroidism, cardiac disease, meningitis, degree of dehydration or provide a clue to disorders of neural and skeletal development. However, the data is scarce. Therefore, this study was aimed to determine AF size and associated factors among term neonates on the first day of life born in Jimma University Medical Center (JUMC), Southwest Ethiopia. Read More

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Arterial Ischemic Stroke-Peculiarities of Clinical Presentation and Risk Factors in Indian Children.

Neuropediatrics 2021 Jun 8. Epub 2021 Jun 8.

Division of Pediatric Neurology, Department of Pediatrics, Dayanand Medical College & Hospital, Ludhiana, Punjab, India.

There are not enough recent studies on arterial ischemic stroke (AIS) in Indian children. We retrospectively reviewed data on 95 children (69 boys), aged 3 months to 17 years, with AIS. Focal signs were noted in 84 (88%) with hemiparesis in 72 (76%). Read More

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Survival following screening and preemptive antifungal therapy for subclinical cryptococcal disease in advanced HIV infection.

AIDS 2021 Jun 4. Epub 2021 Jun 4.

Department of Medicine, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe US Centers for Disease Control and Prevention, Atlanta, GA, United States Health Services Department, City of Harare, Harare, Zimbabwe Division of Epidemiology and Biostatistics, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.

Objectives: Our study's primary objective was to compare 1-year survival rates between serum cryptococcal antigen (sCrAg)-positive and sCrAg-negative HIV-positive individuals with CD4 counts <100 cells/μl without symptoms of meningitis in Zimbabwe.

Design: This was a prospective cohort study.

Methods: Participants were enrolled as either sCrAg-positive or sCrAg-negative and followed up for ≤52 weeks, with death as the outcome. Read More

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Tuberculous meningitis in the elderly.

QJM 2021 Jun 8. Epub 2021 Jun 8.

Professor, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Nehru Hospital, Sector 12, Chandigarh (India).

Objective: Although the elderly population remains at high risk for tuberculosis, studies addressing tuberculous meningitis (TBM) in this age group are scarce. The present study aimed to evaluate the spectrum and outcome of geriatric TBM and document differences between older and young patients.

Methods: A prospective cohort study was conducted in the adult TBM patients admitted at PGIMER, Chandigarh (India). Read More

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Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation.

mSystems 2021 Jun 8:e0004921. Epub 2021 Jun 8.

Key Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.

Bacterial meningitis shows a higher incidence in children than adults, but signs may be scarce. Although some pathogenic microorganisms of meningitis from cerebrospinal fluid (CSF) have been reported, the signature of the representative microbiota in CSF and blood samples from patients remains incompletely revealed. To extend the understanding of the microbiome in patients, we recruited 32 children with bacterial meningitis, 30 undiagnosed infectious children, and 10 matched healthy individuals, which was followed by untargeted metagenomic next-generation sequencing (mNGS) and bioinformatic analysis. Read More

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A study to assess the clinico-radiological presentation and outcome predictors in cases of tubercular meningitis.

Indian J Tuberc 2021 Jul 31;68(3):384-388. Epub 2020 Dec 31.

Department of Pediatrics, Gandhi Medical College, Bhopal, India. Electronic address:

Introduction: Tubercular bacterial meningitis continues to be an important cause of morbidity (especially neurologic handicap) in children from resource-poor countries. The present study was planned to assess the clinical and radiological presentation in cases of tubercular meningitis as well as to study the factors associated with mortality.

Methodology: This study was done over a period of 12 months on children between 5 years and 13 years with suspected TBM. Read More

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Pathogenic mechanism, detection methods and clinical significance of group B streptococcus.

Future Microbiol 2021 Jun 8. Epub 2021 Jun 8.

Department of Central Lab, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai, Shandong, 264200, PR China.

Group B streptococcus (GBS) is the main pathogen of perinatal infection. It can lead to adverse pregnancy, maternal infection, premature delivery, abortion, stillbirth and a series of adverse maternal and infant outcomes such as neonatal sepsis, meningitis or pneumonia during delivery. In order to reduce the infection of perinatal pregnant and the adverse pregnancy outcome, more attention should be paid in the clinical practice, screening efforts, universal detection of GBS infection for pregnant women and preventive treatment for the possible mother infant infection. Read More

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Stable Incidence of Invasive Pneumococcal Disease in Children in Northern France From 2014 Through 2018.

Pediatr Infect Dis J 2021 Jul;40(7):688-693

From the CHU Lille, Pediatric Emergency Unit and Infectious Diseases.

Background: The 13-valent pneumococcal conjugate vaccine (PCV13) has been recommended in France since June 2010. The aim of this study was to evaluate the trends in the incidence of invasive pneumococcal disease (IPD) resulting in hospitalization of children younger than 18 years of age, to identify the vaccination status of these patients and to analyze the serotypic evolution of the pneumococci involved in the various types of IPD.

Methods: This multicenter retrospective study reviewed all admissions of children younger than 18 years of age for IPD from 2014 through 2018 in all hospitals with a pediatric or neonatal unit in northern France. Read More

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Special MRI Techniques to Suss out Spontaneous Cerebrospinal Fluid Leaks.

Top Magn Reson Imaging 2021 Jun;30(3):159-166

Radiology Department, Northwell Health, New Hyde Park, NY.

Abstract: Anterior skull base cerebrospinal fluid (CSF) fistulas result from skull base osteodural defects, allowing subarachnoid space CSF to escape into pneumatized cavities such as the paranasal sinuses and nasal fossa. Precise localization, characterization, and effective treatment of CSF leaks is essential to prevent meningitis, treatment failure, or recurrence. Advances in magnetic resonance imaging have improved radiologists' ability to localize and characterize anterior skull base CSF fistulas. Read More

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Acute Sterile Meningitis as a Primary Manifestation of Pituitary Apoplexy.

AACE Clin Case Rep 2021 Mar-Apr;7(2):117-120. Epub 2020 Dec 28.

Department of Internal Medicine, Texas Health Presbyterian Hospital of Dallas, Dallas, Texas.

Objective: We report a case of pituitary apoplexy (PA) with negative radiographic findings for PA and cerebrospinal fluid (CSF) analysis consistent with neutrophilic meningitis. PA is a rare endocrinopathy requiring prompt diagnosis and treatment. Presentation with acute neutrophilic meningitis is uncommon. Read More

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December 2020

Ventriculitis: A Severe Complication of Central Nervous System Infections.

Open Forum Infect Dis 2021 Jun 29;8(6):ofab216. Epub 2021 Apr 29.

Department of Neurosurgery, Rennes University Hospital, Rennes, France.

Background: Ventriculitis, a dreaded complication of brain abscess, meningitis, and various neurosurgical procedures, has attracted limited attention in the medical literature.

Methods: This is a retrospective, single-center study. We screened the medical files of all patients who had a brain imaging report that included the word "ventriculitis" during years 2005-2019. Read More

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Temporal phylogeny and molecular characterization of echovirus 30 associated with aseptic meningitis outbreaks in China.

Virol J 2021 Jun 6;18(1):118. Epub 2021 Jun 6.

WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory of biosafety, National Health Commission Key Laboratory of Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China.

Background: An outbreak of aseptic meningitis occurred from June to August 2016, in Inner Mongolia Autonomous Region, China.

Methods: To determine its epidemiological characteristics, etiologic agent, and possible origin, specimens were collected for virus isolation and identification, followed by molecular epidemiological analysis.

Results: A total of 363 patients were clinically diagnosed from June 1st to August 31st 2016, and most cases (63. Read More

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Coinfection of Sphingomonas paucimobilis meningitis and Listeria monocytogenes bacteremia in an immunocompetent patient.

Yeungnam Univ J Med 2021 Jun 7. Epub 2021 Jun 7.

Department of Laboratory Medicine, Yeungnam University College of Medicine, Daegu, Korea.

This report describes a case of coinfection of Sphingomonas paucimobilis meningitis and Listeria monocytogenes bacteremia in a 66-year-old immunocompetent female patient. The patient had undergone traditional procedures, including acupuncture, which possibly caused the coinfection. During treatment with susceptible antibiotics for bacterial meningitis, she developed hydrocephalus on the third day. Read More

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The impact of viral infections on childhood central nervous system infections.

J Clin Virol 2021 May 11;140:104853. Epub 2021 May 11.

Laboratório de Vírus, Departamento de Microbiologia, Universidade Federal de Minas Gerais, Minas Gerais, Brazil. Electronic address:

Background: Viruses are a common cause of central nervous system (CNS) infections. However, studies of CNS viral pathogens in pediatric patients are poorly explored because viral infections are often erroneously diagnosed as bacterial infections.

Methods: 299 CNS samples were collected from pediatric patients aged from one month to 14 years old. Read More

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Epidemiology and clinical characteristics of Klebsiella spp. meningitis in France.

Infect Dis Now 2021 Jun 3. Epub 2021 Jun 3.

Institut Micalis UMR 1319, Université Paris-Saclay, INRAe, AgroParisTech, Châtenay Malabry, France. Service de microbiologie clinique, GH Paris Saint-Joseph, 75014 Paris, France; Laboratoire de Bactériologie, Département des Agents infectieux, CHU Saint Louis-Lariboisière-Fernand Widal, APHP, 75010 Paris, France.

Objectives: To describe the epidemiology of Klebsiella spp. meningitis in France with respect to clinical and bacteriological data.

Methods: We performed a four-year multicenter, retrospective, observational study. Read More

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A decade of drug-resistant tuberculous meningitis: A wake-up call for patient-centric therapy.

Indian J Med Microbiol 2021 Jun 2. Epub 2021 Jun 2.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

On analyzing the drug susceptibility profile of 151 clinical isolates collected from patients of tuberculous meningitis (TBM) over 10 years, we reflect on few lessons learnt from the trend of susceptibility profile - drug resistance was not uncommon, fluoroquinolone resistance was observed even among otherwise susceptible isolates and hetero-resistance was observed against rifampicin, isoniazid and also fluoroquinolones. In the midst of widening gap between incidence of drug resistant TBM and availability of effective drugs, our data suggests that universal testing for drug resistance, careful choice of drugs having optimal penetration and individualized therapy should form important pillars of TBM management. Read More

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Pediatric sepsis cases diagnosed with group B streptococcal meningitis using next-generation sequencing: a report of two cases.

BMC Infect Dis 2021 Jun 5;21(1):531. Epub 2021 Jun 5.

Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: Group B Streptococcus (GBS) is an important cause of invasive infection in neonates and infants. Cerebrospinal fluid (CSF) findings and culture may not show evidence of infection early in GBS meningitis. Next-generation sequencing (NGS) has the potential to detect microbial genetic material in patients with infectious diseases. Read More

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MENINGO-ENCEPHALITIS IN A MIDDLE-AGED WOMAN HOSPITALIZED FOR COVID-19.

Wiad Lek 2021 ;74(5):1274-1276

SUMY STATE UNIVERSITY, SUMY, UKRAINE.

Objective: The aim: To pay attention of clinicians to possible lesions of the central nervous system (encephalitis) in patients with COVID-19.

Patients And Methods: Case presentation: A 44-year-old woman was admitted to our clinic because of 2-month-history of mild fever, bilateral lower lobe pneumonia, respiratory failure, generalized weakness, and some neurologic symptoms. SARS-CoV-2 RNA was detected in nasopharyngeal swab. Read More

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Duodenal perforation as a postoperative complication after ventriculoperitoneal shunt: A case report.

Int J Surg Case Rep 2021 May 29;83:106059. Epub 2021 May 29.

Department of Surgery, Hanoi Medical University, Hanoi, Viet Nam. Electronic address:

Introduction And Importance: Ventriculoperitoneal shunt (VP shunt) is the one of the most common and important tools for the treatment of hydrocephalus. It requires simple technique and demonstrates effectiveness in treating hydrocephalus. However, many complications have been reported such as infection, valve obstruction, valve dysfunction and abdominal complications. Read More

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Enterovirus Meningitis in Adults: A Prospective Nationwide Population-Based Cohort Study.

Neurology 2021 Jun 4. Epub 2021 Jun 4.

Department of Infectious Diseases, Aarhus University Hospital, Skejby, 8200 Aarhus N, Denmark.

Objective: To test the hypothesis that enterovirus meningitis (EM) is a frequent and self-limiting condition, the epidemiology of enterovirus meningitis (EM) in adults was examined.

Methods: Using a prospective, nationwide, population-based database, all adults with EM confirmed by PCR of the cerebrospinal fluid (CSF) from 2015-2019 were included. Unfavorable outcome was defined as Glasgow Outcome Scale (GOS) scores of 1-4 at discharge. Read More

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Inhibition effect of oxyepiberberine isolated from Coptis chinensis franch. On non-small cell lung cancer based on a network pharmacology approach and experimental validation.

J Ethnopharmacol 2021 Jun 1;278:114267. Epub 2021 Jun 1.

Faculty of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China; Key Laboratory of Traditional Chinese Medicine Resources and Chemistry of Hubei Province, Wuhan, 430061, China. Electronic address:

Ethnopharmacological Relevance: As an important Chinese herb, Coptis chinensis Franch. (Huanglian, HL) has a long history of usage for clearing heat, eliminating dampness, purging fire and detoxification in Traditional Chinese Medicine (TCM). HL, also called goldthread, was frequently used for the treatment of typhoid, tuberculosis, epidemic cerebrospinal meningitis, pertussis, and other lung-related diseases. Read More

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Clinical Significance of Positive Results of the BioFire Cerebrospinal Fluid FilmArray Meningitis/Encephalitis Panel at a Tertiary Medical Center in the United States.

Arch Pathol Lab Med 2021 Jun 4. Epub 2021 Jun 4.

From the Division of Critical Care and Hospitalist Neurology, Department of Neurology (Waldrop, Radmard, Thakur), Columbia University Irving Medical Center, New York, New York.

Context.—: The FilmArray Meningitis/Encephalitis (ME) panel is the first US Food and Drug Administration-cleared multiplex polymerase chain reaction panel for the detection of central nervous system infections. While the assay's performance characteristics have been described, the real-world significance of positive results has not been fully characterized. Read More

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