76,160 results match your criteria Meningitis


Value of lipocalin 2 as a potential biomarker for bacterial meningitis.

Clin Microbiol Infect 2020 Jul 10. Epub 2020 Jul 10.

Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam. Electronic address:

Objectives: Central nervous system (CNS) infections are common causes of morbidity and mortality worldwide. We aimed to discover protein biomarkers that could rapidly and accurately identify the likely cause of the infections, essential for clinical management and improving outcome.

Methods: We applied liquid chromatography tandem mass-spectrometry on 45 cerebrospinal fluid (CSF) samples from a cohort of adults with/without CNS infections to discover potential diagnostic biomarkers. Read More

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http://dx.doi.org/10.1016/j.cmi.2020.07.006DOI Listing

Risk Factors and Management of Postoperative Infection Following Cochlear Implantation.

Otol Neurotol 2020 Aug;41(7):e823-e828

Department of Otolaryngology, New York University School of Medicine, New York, New York.

Objective: To determine factors associated with infection, management, and resultant outcomes following pediatric cochlear implantation.

Study Design: Retrospective cohort study with nested case series.

Setting: Tertiary academic medical center. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002685DOI Listing

Cefepime-Induced Encephalopathy in a Tertiary Medical Center in Korea.

J Clin Neurol 2020 Jul;16(3):408-415

Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.

Background And Purpose: Cefepime is a widely used fourth-generation cephalosporin. It is commonly used as a first-line antibiotic to treat various infectious diseases such as hospital-acquired pneumonia, urinary tract infections, and bacterial meningitis. The primary outcome of this study was the development of cefepime-induced encephalopathy (CIE) at a tertiary medical center in Korea. Read More

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http://dx.doi.org/10.3988/jcn.2020.16.3.408DOI Listing

Parechovirus infection causing sepsis-like illness in newborns: a NICU approach.

New Microbiol 2020 Jun 13;43(3). Epub 2020 Jun 13.

Neonatal Intensive Care Unit, St. Orsola-Malpighi Hospital, University of Bologna, Italy.

Human parechovirus (HpeV) is an important emerging infection in young infants, able to cause sepsis-like disease and meningoencephalitis, especially in newborns. Among the 19 identified genotypes, HPeV1, 3 and 6 are the most common types involved in human infections; HPeV3 is the type mainly responsible for neonatal infections and for infections involving the central nervous system. Signs and symptoms overlap with those of a bacterial infection and patients are usually treated with broad spectrum antibiotics. Read More

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Diplopia Presenting in a Case of Pineal Metastasis of Pulmonary Sarcomatoid Carcinoma Refractory to Treatment.

Asian J Neurosurg 2020 Apr-Jun;15(2):449-454. Epub 2020 Apr 4.

Department of Neurosurgery, Fujita Health University, Toyoake, Aichi, Japan.

A 42-year-old male presented with diplopia, headache, and nausea. Magnetic resonance imaging (MRI) of the brain showed pineal tumor, and chest computed tomography (CT) demonstrated a lung tumor. Disorientation developed, with occurrence of hydrocephalus, and we performed neuroendoscopic surgery for biopsy of the pineal tumor and third ventriculostomy. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_60_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335143PMC

Endoscopic Third Ventriculostomy for Hydrocephalus in Infants: A Single-center Experience.

Asian J Neurosurg 2020 Apr-Jun;15(2):302-305. Epub 2020 May 29.

Departments of Neurosurgery MB Hospital, RNT Medical College, Udaipur, Rajasthan, India.

Introduction: Hydrocephalus remains one of the more common pathologies managed in pediatric neurosurgery. Endoscopic third ventriculostomy (ETV) has become the procedure of choice for the treatment of hydrocephalus due to aqueductal stenosis with high success rate. It has an advantage over ventriculoperitoneal (VP) shunting, as it enables patients to remain device free. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_17_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335137PMC

The Characterization of Two-Component System PmrA/PmrB in .

Front Microbiol 2020 17;11:903. Epub 2020 Jun 17.

Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.

is an opportunistic Gram-negative pathogen that could cause meningitis and necrotizing enterocolitis. Several Gram-negative bacteria use the PmrA/PmrB system to sense and adapt to environmental change by resistance to cationic antimicrobial peptides of host immune systems. The PmrA/PmrB two-component system regulates several genes to modify LPS structure in the bacterial outer membrane. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326031PMC

Successful containment of horizontal enterovirus infection in a neonatal unit in Singapore through diagnosis by polymerase chain reaction (PCR) and direct sequence analysis.

J Infect Public Health 2020 Jul 8. Epub 2020 Jul 8.

Department of Neonatology, KK Women's and Children's Hospital, Singapore; Duke-National University of Singapore Graduate Medical School, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Lee Kong Chian School of Medicine, National Technological University, Singapore.

Background: Enterovirus (EV) outbreaks often coincide with seasonal peaks in the community. However, they may also sporadically occur in neonatal units. Identification of EV infection in neonates can be challenging, as they tend to present with mild or nonspecific symptoms. Read More

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http://dx.doi.org/10.1016/j.jiph.2020.06.029DOI Listing

Prevalence and association of Panton-Valentine Leukocidin gene with the risk of sepsis in patients infected with Methicillin Resistant Staphylococcus aureus.

J Infect Public Health 2020 Jul 8. Epub 2020 Jul 8.

Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Universiti Sains Malaysia, Health Campus, USM, 16150 Kubang Kerian, Kelantan, Malaysia. Electronic address:

Background: Panton-Valentine Leukocidin (PVL), is one of the virulence gene expressed by Methicillin Resistant Staphylococcus aureus (MRSA) and is known to be associated with severe form of community acquired MRSA infection. The aim of this study is to investigate its prevalence in our setting and patient's clinical outcome.

Methods: A cross sectional study involve retrospective record review were done involving 90 MRSA positive isolates between November 2016 and October 2017. Read More

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http://dx.doi.org/10.1016/j.jiph.2020.06.018DOI Listing

Clinical characteristics of echovirus 11 and coxsackievirus B5 infections in Taiwanese children requiring hospitalization.

J Microbiol Immunol Infect 2020 Jul 4. Epub 2020 Jul 4.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, 333 Taoyuan, Taiwan; School of Medicine, College of Medicine, Chang Gung University, 333 Taoyuan, Taiwan. Electronic address:

Background: Severe illness can occur in young children infected with certain types of enteroviruses including echovirus 11 (Echo11) and coxsackievirus B5 (CoxB5). The manifestations and outcomes of Echo11 and CoxB5 diseases across all ages of children remained not comprehensively characterized in Taiwan.

Methods: Culture-confirmed Echo11 (60 patients) or CoxB5 (65 patients) infections were identified in a hospital from 2010 to 2018. Read More

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http://dx.doi.org/10.1016/j.jmii.2020.06.008DOI Listing

Aseptic meningitis outbreak associated with echovirus 4 in Northern Europe in 2013-2014.

J Clin Virol 2020 Jul 7;129:104535. Epub 2020 Jul 7.

University of Helsinki and Helsinki University Hospital, Virology and Immunology, Helsinki, Finland. Electronic address:

Picornaviruses (family Picornaviridae) are small, nonenveloped, positive-sense, single-stranded RNA viruses. The members of this family are currently classified into 47 genera and 110 species. Of picornaviruses, entero- and parechoviruses are associated with aseptic meningitis. Read More

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http://dx.doi.org/10.1016/j.jcv.2020.104535DOI Listing

Prevalence of Haemophilus parasuis"Glaesserella parasuis" in pigs in China: A systematic review and meta-analysis.

Prev Vet Med 2020 Jul 1;182:105083. Epub 2020 Jul 1.

College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong Province, 266109, PR China. Electronic address:

Haemophilus parasuis, a gram-negative bacterium as an early commensal colonizer in the upper respiratory tract of weaning pigs (Sus scrofa), is one of the most important bacterial pathogens affecting pig populations. It is the causative agent of Glässer's disease, causing systemic infection and polyserositis, meningitis, and arthritis. H. Read More

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http://dx.doi.org/10.1016/j.prevetmed.2020.105083DOI Listing

Persistent aseptic meningitis in a child-think patch.

Wien Med Wochenschr 2020 Jul 10. Epub 2020 Jul 10.

Hospital for General Paediatrics and Neonatology, Saarland University Medical Center, Homburg/Saar, Germany.

Background: In patients with neurosurgical interventions requiring dura reconstruction, the use of bovine graft material may be required.

Patients And Methods: Case report.

Results: We present a 12-year-old girl with a profound graft reaction with severe neurologic symptoms mimicking post-neurosurgical bacterial meningitis after resection of an infra-tentorial brain tumour. Read More

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http://dx.doi.org/10.1007/s10354-020-00765-yDOI Listing

Giant chronic calcified subdural empyema: a case report.

J Med Case Rep 2020 Jul 11;14(1):95. Epub 2020 Jul 11.

Department of Surgery, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Chronic calcified subdural empyema is an exceedingly rare central nervous system infection with a handful of cases published to date. Reported cases presented with nonspecific clinical signs and symptoms. The duration between the initial onset of symptoms and diagnosis can vary drastically from a few years to up to 46 years. Read More

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http://dx.doi.org/10.1186/s13256-020-02429-2DOI Listing

Addressing advanced HIV disease and mortality in global HIV programming.

AIDS Res Ther 2020 Jul 10;17(1):40. Epub 2020 Jul 10.

Division of Global HIV and TB, Center for Global Health, Centers for Disease Control and Prevention, 1600 Clifton Road NE, US 1-1, Atlanta, GA, 30329, USA.

Introduction: The US President's Emergency Plan for AIDS Relief (PEPFAR) was launched to increase access to antiretroviral treatment (ART) among people living with HIV (PLHIV) and to prevent new HIV infections globally. As new infections have decreased in many PEPFAR-supported countries, PEPFAR is increasingly focusing on understanding and decreasing mortality among PLHIV, specifically by addressing advanced HIV disease (AHD) and its attendant opportunistic infections (OIs). Several developments in identifying AHD, in preventing, diagnosing, and treating selected OIs, and in PEPFAR's support for mortality surveillance make this an opportune moment for PEPFAR to address HIV-related mortality. Read More

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http://dx.doi.org/10.1186/s12981-020-00296-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348123PMC

Linezolid for therapy of meningitis: a cohort study of 26 patients.

Infect Dis (Lond) 2020 Jul 10:1-8. Epub 2020 Jul 10.

Clinical Microbiology Service, Hospital Clínico San Carlos, Madrid, Spain.

Background: Linezolid has good penetration to the meninges and could be an alternative for treatment of meningitis. We assessed the efficacy and safety of linezolid therapy for this infection.

Methods: Retrospective multicenter cohort study of 26 adults treated with linezolid, derived from a cohort of 350 cases of meningitis diagnosed at 11 university hospitals in Spain (1981-2015). Read More

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http://dx.doi.org/10.1080/23744235.2020.1789212DOI Listing

Neurological manifestations of adult-onset Still's disease-case-based review.

Clin Rheumatol 2020 Jul 9. Epub 2020 Jul 9.

Department of Internal Medicine of Centro Hospitalar Barreiro-Montijo EPE, Barreiro, Portugal.

Adult-onset Still's disease (AOSD) is a rare inflammatory disorder in which pathophysiology is yet to be fully understood. We report the case of a 66-year-old male that presents with fever, arthralgia, and laboratory abnormalities suggestive of a systemic inflammatory disease. During a diagnostic workout, the patient developed neurological symptoms, namely a sudden confounding syndrome and hearing loss that improved with corticosteroid therapy. Read More

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http://dx.doi.org/10.1007/s10067-020-05244-8DOI Listing

Rare case of meningitis due to an emerging pathogen .

SAGE Open Med Case Rep 2020 26;8:2050313X20936098. Epub 2020 Jun 26.

Department of Neurosurgery, Lok Nayak Hospital, Maulana Azad Medical College, New Delhi, India.

is a non-glucose fermenting Gram-negative bacteria widely distributed in nature. It has been found to cause a variety of infections like nosocomial pneumonia, bacteremia and wound infections usually in immunosuppressed patients and those with indwelling devices. The organism is resistant to a significant number of the commonly prescribed broad spectrum antibiotics. Read More

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http://dx.doi.org/10.1177/2050313X20936098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328054PMC

One-month-old boy with group B streptococcal meningitis, subdural effusion, and high levels of interleukin-6.

J Infect Chemother 2020 Jul 6. Epub 2020 Jul 6.

Department of Pediatrics, National Hospital Organization Saitama Hospital, 2-1 Suwa, Wako-shi, Saitama, 321-0102, Japan. Electronic address:

Meningitis is associated with elevated levels of inflammatory cytokines in the blood, cerebrospinal fluid (CSF), and subdural fluid. Subdural effusion prolongs fever in patients with meningitis. However, the reason for this remains unclear. Read More

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http://dx.doi.org/10.1016/j.jiac.2020.06.017DOI Listing

Autoimmune glial fibrillary acidic protein astrocytopathy mimics infectious meningitis: Two case reports.

Mult Scler Relat Disord 2020 Jul 1;45:102350. Epub 2020 Jul 1.

Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China. Electronic address:

Background: Autoimmune glial fibrillary acidic protein astrocytopathy (A-GFAP-A) has been recently characterized as a novel autoimmune central nervous system (CNS) disorder with GFAP antibody as the biomarker. However, nonspecific symptoms of A-GFAP-A contribute to misdiagnosis.

Case Presentation: The patients presented with initial symptoms of fever, headache, and nuchal rigidity. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102350DOI Listing

The Lyme disease bacterium, Borrelia burgdorferi, stimulates an inflammatory response in human choroid plexus epithelial cells.

PLoS One 2020 9;15(7):e0234993. Epub 2020 Jul 9.

Department of Biomedical Sciences, University of North Dakota, Grand Forks, North Dakota, United States of America.

The main functions of the choroid plexus (CP) are the production of cerebral spinal fluid (CSF), the formation of the blood-CSF barrier, and regulation of immune response. This barrier allows for the exchange of specific nutrients, waste, and peripheral immune cells between the blood stream and CSF. Borrelia burgdorferi (Bb), the causative bacteria of Lyme disease, is associated with neurological complications including meningitis-indeed, Bb has been isolated from the CSF of patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234993PLOS

Acute neonatal Listeria monocytogenes infection causes long-term, organ-specific changes in immune cell subset composition.

Eur J Microbiol Immunol (Bp) 2020 Jun 19. Epub 2020 Jun 19.

1Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.

Listeria monocytogenes (Lm) is a food-borne pathogen with a high chance of infecting neonates, pregnant women, elderly and immunocompromised individuals. Lm infection in neonates can cause neonatal meningitis and sepsis with a high risk of severe neurological and developmental sequelae and high mortality rates. However, whether an acute neonatal Lm infection causes long-term effects on the immune system persisting until adulthood has not been fully elucidated. Read More

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http://dx.doi.org/10.1556/1886.2020.00007DOI Listing

Bacterial Meningitis in Patient with Sigmoid Sinus Diverticulum.

Neurol India 2020 May-Jun;68(3):694-695

Department of Neurology, University of Rochester Medical Center, 601 Elmwood Ave. Box 673, Rochester NY, 14642, USA.

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http://dx.doi.org/10.4103/0028-3886.288978DOI Listing

Postcryptococcal Moyamoya Syndrome: Case Report and Review of Literature.

Neurol India 2020 May-Jun;68(3):660-664

Department of Neurology, Aster Medcity, Kochi, Kerala, India.

There could be an association between cryptococcal meningitis and the later development of moyamoya syndrome. We performed serial clinical and radiological assessments in an immunosuppressed post-renal transplant patient who had previously suffered from cryptococcal meningitis and then went on to develop a moyamoya syndrome (MMS). We also performed a literature search and review of post-infectious MMS cases from 1976 to 2019. Read More

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http://dx.doi.org/10.4103/0028-3886.288983DOI Listing

Acute longus colli tendinitis: Case report of a rare cause of neck pain.

Radiol Case Rep 2020 Sep 2;15(9):1433-1436. Epub 2020 Jul 2.

University of South Florida Department of Radiology, 2 Tampa General Circle, STC 6102, Tampa, FL 33606, USA.

Longus colli tendonitis is an uncommon aseptic inflammatory condition that affects the prevertebral longus colli tendon, which is a muscle that courses anteriorly from the level of the C1 to T3 vertebrae (1,2). Although longus colli tendonitis is a self-limited condition, the longus colli muscle is anterior to the prevertebral space and posterior to the pharyngeal constrictors, therefore when inflamed, leads to a myriad of symptoms that often mimic more serious conditions such as retropharyngeal abscess or meningitis (2). We present a case of a 39-year-old white male that presented with neck pain, neck stiffness, and pain with swallowing. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.05.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334548PMC
September 2020

A metagenomics-based diagnostic approach for central nervous system infections in hospital acute care setting.

Sci Rep 2020 Jul 8;10(1):11194. Epub 2020 Jul 8.

British Columbia Children's Hospital, Vancouver, BC, Canada.

The etiology of central nervous system (CNS) infections such as meningitis and encephalitis remains unknown in a large proportion of cases partly because the diversity of pathogens that may cause CNS infections greatly outnumber available test methods. We developed a metagenomic next generation sequencing (mNGS)-based approach for broad-range detection of pathogens associated with CNS infections suitable for application in the acute care hospital setting. The analytical sensitivity of mNGS performed on an Illumina MiSeq was assessed using simulated cerebrospinal fluid (CSF) specimens (n = 9). Read More

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http://dx.doi.org/10.1038/s41598-020-68159-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343800PMC

Anti-agalactosyl Immunoglobulin G Antibodies in Probable Rheumatoid Meningitis.

Intern Med 2020 Jul 7. Epub 2020 Jul 7.

Department of Neurology, Japanese Red Cross Medical Center, Japan.

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http://dx.doi.org/10.2169/internalmedicine.5016-20DOI Listing

Immune responses of meningococcal B outer membrane vesicles in middle-aged mice.

Pathog Dis 2020 Jul 8. Epub 2020 Jul 8.

Department of Immunology, Adolfo Lutz Institute, Sao Paulo, Brazil.

The elderly are more likely to die when infected with Neisseria meningitidis. Aging is associated with immune system dysfunctions that impair responses to vaccines and infections. Therefore, immunization of middle-aged individuals could be beneficial. Read More

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http://dx.doi.org/10.1093/femspd/ftaa028DOI Listing

International Survey on Determinants of Antibiotic Duration and Discontinuation in Pediatric Critically Ill Patients.

Pediatr Crit Care Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.

Objectives: We hypothesized that antibiotic use in PICUs is based on criteria not always supported by evidence. We aimed to describe determinants of empiric antibiotic use in PICUs in eight different countries.

Design: Cross-sectional survey. Read More

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http://dx.doi.org/10.1097/PCC.0000000000002397DOI Listing

Time to positive culture can differentiate post-neurosurgical coagulase-negative Staphylococci other than S epidermidis meningitis from contamination: A case-control observational study.

J Clin Lab Anal 2020 Jul 7:e23447. Epub 2020 Jul 7.

Department of Clinical Diagnosis, Laboratory of Beijing Tiantan Hospital and Capital Medical University, Beijing, China.

Objective: To explore the characteristics of coagulase-negative Staphylococci other than Staphylococci epidermidis (Nse-CoNS) meningitis and to apply cerebrospinal fluid (CSF) times to positivity culture (TTPC) for the precise differentiation of meningitis from contamination.

Methods: We conducted a case-control study to accomplish the following: First, we retrospectively reviewed records of post-neurosurgical patients' CSF that yielded Nse-CoNS from January to October 2019 at the Beijing Tiantan Hospital; 17 clinical and 12 laboratory characteristics were reviewed. Second, we investigated the TTPC of the Nse-CoNS, the cutoffs, and corresponding parameters to differentiate Nse-CoNS meningitis from contamination. Read More

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http://dx.doi.org/10.1002/jcla.23447DOI Listing

Gonococcal osteomyelitis in a pediatric patient with disseminated gonococcal infection: Implications for antimicrobial management.

IDCases 2020 18;21:e00875. Epub 2020 Jun 18.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Blvd, Hempstead, New York, 11549, United States.

We report a case of a female teenager with gonococcal septic arthritis of the right shoulder that also caused osteomyelitis of the humeral head. Infection with is a frequently diagnosed sexually transmitted infection in the sexually active teenage population and disseminated gonococcal infection (DGI) is the most common systemic manifestation of acute gonorrhea. DGI commonly involves acute arthritis, tenosynovitis and dermatitis with less common complications of endocarditis, hepatitis and meningitis. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327928PMC

Surgical wound infection caused by a multi drug resistant Serotype 19A after a total coloproctectomy with ileostomy.

Pan Afr Med J 2020 6;35:97. Epub 2020 Apr 6.

Department of Microbiology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.

colonizes asymptomatically the human nasopharynx. This pathogen is responsible for sinusitis, otitis media, pneumonia, bacteremia and meningitis. We report the case of a 35-year-old female patient who developed a surgical wound infection by a multi drug resistant serotype 19A after a total coloprotectomy. Read More

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http://dx.doi.org/10.11604/pamj.2020.35.97.19128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320775PMC

Scrub Typhus in Children at Tribhuvan University Teaching Hospital in Nepal.

Authors:
Luna Bajracharya

Pediatric Health Med Ther 2020 30;11:193-202. Epub 2020 Jun 30.

Department of Pediatrics, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

Introduction: Scrub typhus is an acute undifferentiated febrile illness with varied nonspecific manifestations. It dramatically responds to appropriate antibiotic if started earlier in the course of disease leading to significant reduction in morbidities and mortalities.

Objective: To describe the clinical profile, treatment and prognosis of scrub typhus in children. Read More

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http://dx.doi.org/10.2147/PHMT.S253106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335309PMC

Community-Acquired Methicillin-Resistant ST59 in a Chinese Adult with Meningitis: A Case Report from China.

Infect Drug Resist 2020 29;13:2011-2016. Epub 2020 Jun 29.

Department of Respiratory Diseases, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.

Community-acquired methicillin-resistant (CA-MRSA) infections are reported worldwide and are associated with serious outcomes. The majority of CA-MRSA infections are soft tissue and skin infections, and cases with meningitis caused by CA-MRSA are rare. Here, we reported a 53-year-old male patient with meningitis due to CA-MRSA infection, as confirmed by cerebrospinal fluid examination. Read More

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http://dx.doi.org/10.2147/IDR.S253407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334018PMC

West Nile Virus in Slovenia.

Viruses 2020 Jul 3;12(7). Epub 2020 Jul 3.

Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.

West Nile virus (WNV) is a flavivirus transmitted by mosquitoes. Birds are the reservoir for the virus; humans, horses and other mammals are dead-end hosts. Infections caused by WNV in humans can vary from asymptomatic infections to West Nile fever (WNF) or West Nile neuroinvasive disease (WNND). Read More

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http://dx.doi.org/10.3390/v12070720DOI Listing

A new case of congenital ficolin-3 deficiency with primary immunodeficiency.

Expert Rev Clin Immunol 2020 Jul 7. Epub 2020 Jul 7.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences , Tehran, Iran.

Objectives: Human Ficolin-3 () is an oligomeric-structured lectin encoded by the gene with a pivotal role in the lectin complement pathway. It has anti-microbial activities against bacterial and viral infections and restrains opportunistic pathogens. Mutation in the gene is associated with variable clinical manifestations particularly immunologic (infections and autoimmunity) and neurologic complications. Read More

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http://dx.doi.org/10.1080/1744666X.2020.1792779DOI Listing

MOG antibody syndrome presenting as aseptic meningitis: an evolving spectrum.

Neurol Sci 2020 Jul 6. Epub 2020 Jul 6.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1007/s10072-020-04558-4DOI Listing
July 2020
1.495 Impact Factor

Pregabalin-associated stuttering and frequent blepharospasm: case report and review.

Daru 2020 Jul 6. Epub 2020 Jul 6.

Department of Dermatology, the First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, 16766 Jing-Shi Road, Jinan, 250014, China.

Herpes zoster is an acute, painful, herpes skin disease caused by varicella-zoster virus, which may cause viral meningitis. Pregabalin has been shown to be efficacious in the treatment of pain in patients with herpes zoster. However, it has the side effects of neurotoxicity. Read More

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http://dx.doi.org/10.1007/s40199-020-00354-9DOI Listing

Tackling cryptococcal meningitis in Nigeria, one-step at a time; the impact of training.

PLoS One 2020 6;15(7):e0235577. Epub 2020 Jul 6.

Mycotic Diseases Branch, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, United States of America.

Background: Nigeria is estimated to have 25,000 cases of cryptococcal antigenemia (CrAg) annually. CrAg screening with pre-emptive fluconazole treatment is recommended but not yet implemented in Nigeria. Trainings were conducted to improve health-care provider (HCP) awareness and clinical skills in the management and prevention of cryptococcal meningitis (CM). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235577PLOS

[Etiology and clinical symptoms of bilateral vestibulopathy].

Vestn Otorinolaringol 2020 ;85(3):32-35

Sverzhevsky Research Clinical Institute of Otorhinolaryngology of the Moscow Healthcare Department, Moscow, Russia.

Objective: To identify etiology, clinical symptoms of bilateral vestibulopathy (BV) depending on etiology.

Results: Idiopathic BV was identifies in one third of patients. The most common identified reasons are Meniere's disease, meningitis and ototoxicity. Read More

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http://dx.doi.org/10.17116/otorino20208503132DOI Listing
January 2020

Relationship Between Clozapine Levels and Acute Inflammatory Stress.

Prim Care Companion CNS Disord 2020 Jul 2;22(4). Epub 2020 Jul 2.

Napa State Hospital, 2100 Napa Vallejo Hwy, Napa, CA 94558.

Stress-induced changes in pharmacokinetics can significantly alter the plasma levels of some drugs such as clozapine. This report describes the case of a middle-aged man with schizoaffective disorder, bipolar type who showed sustained elevation in clozapine levels 3 days after discontinuation. Before the clozapine levels were drawn, he had developed acute bacterial pneumonia and signs of acute bacterial meningitis followed by neuroleptic malignant syndrome after he received multiple doses of intravenous haloperidol for worsening psychosis and aggressive behavior. Read More

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http://dx.doi.org/10.4088/PCC.19br02586DOI Listing

Cerebrospinal Fluid Leaks and Pseudomeningocele after Posterior Fossa Surgery: Effect of an Autospray Dural Sealant.

Cureus 2020 May 31;12(5):e8379. Epub 2020 May 31.

Neurological Surgery, University of California, San Francisco, USA.

Background Posterior fossa craniotomies can be complicated by cerebrospinal fluid (CSF) leaks, infection, meningitis, neurologic deficits, and intracranial hypotension caused by defective closure of the dura. Secondary dural closures such as pericranial graft, muscle graft, glue, sealants, or fat graft are used. However, there have been few studies examining the use of sealants with a polyethylene glycol and polyethylenimine component. Read More

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http://dx.doi.org/10.7759/cureus.8379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328695PMC

[Paroxysmal nocturnal hemoglobinuria treated with eculizumab in Wakayama, Japan: a retrospective analysis].

Rinsho Ketsueki 2020 ;61(6):605-611

Department of Hematology/Oncology, Wakayama Medical University.

Currently, the humanized anti-C5 monoclonal antibody, eculizumab, is widely used for treating paroxysmal nocturnal hemoglobinuria (PNH) due to its effects on suppression of intravascular hemolysis and resulting improvement in quality of life. However, in some cases, this treatment is refractory or is associated with meningococcal meningitis. No region-specific analyses have been published, and currently, information on region specificity and genetic factors is limited. Read More

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http://dx.doi.org/10.11406/rinketsu.61.605DOI Listing
January 2020

Update on invasive fungal infections in the Middle Eastern and North African region.

Braz J Microbiol 2020 Jul 5. Epub 2020 Jul 5.

Laboratoire Microbiologie Santé et Environnement (LMSE), Doctoral School of Science and Technology, Faculty of Public Health, Lebanese University, Tripoli, Lebanon.

In the recent years, the epidemiology of invasive fungal infections (IFIs) has changed worldwide. This is remarkably noticed with the significant increase in high-risk populations. Although surveillance of such infections is essential, data in the Middle Eastern and North African (MENA) region remain scarce. Read More

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http://dx.doi.org/10.1007/s42770-020-00325-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335363PMC
July 2020
0.592 Impact Factor

A case of cryopyrin-associated periodic fever syndrome during canakinumab administration complicated by inflammatory bowel disease.

Clin Rheumatol 2020 Jul 5. Epub 2020 Jul 5.

Department of Pediatrics, Kagoshima University Hospital, 35-1 Sakuragaoka Kagoshimashi, Kagoshima, 890-8520, Japan.

Cryopyrin-associated periodic fever syndrome (CAPS) is a highly debilitating disorder, which is characterized by unregulated interleukin-1β production driven by autosomal dominantly inherited mutations in the NLRP3 gene. Patients with CAPS often present with early-onset episodes of fever and rash. These patients also present with variable systemic signs and symptoms, such as arthritis, sensorineural hearing loss, chronic aseptic meningitis, and skeletal abnormalities, but minimal gastrointestinal symptoms. Read More

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http://dx.doi.org/10.1007/s10067-020-05267-1DOI Listing

Susceptibility of tick-borne encephalitis virus to inactivation by heat, acidic pH, chemical or UV treatment.

J Infect Dis 2020 Jul 5. Epub 2020 Jul 5.

Institute for Physiological Chemistry and Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany.

Tick-borne encephalitis virus (TBEV) is a single-stranded, positive-sense RNA virus in the family Flaviviridae that is endemic in parts of Europe and Asia and can cause meningitis or encephalitis. Due to the disease severity, TBEV requires handling under heightened biosafety measures. The establishment and validation of inactivation procedures is a prerequisite for downstream analyses and management of occupational exposure. Read More

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http://dx.doi.org/10.1093/infdis/jiaa405DOI Listing

First report of meningococcal ciprofloxacin resistance in Greece due to invasive isolates of the sequence type ST-3129.

Eur J Clin Microbiol Infect Dis 2020 Jul 3. Epub 2020 Jul 3.

Invasive Bacterial Infections Unit, Institute Pasteur, Paris, France.

A local outbreak caused by Neisseria meningitidis occurred in the migration camp in the Greek island of Lesbos during January-February 2020 (4 of 5 cases). In total, 5 samples positive for N. meningitidis were further investigated for sero-/genogroup, PorA, and WGS analysis. Read More

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http://dx.doi.org/10.1007/s10096-020-03965-xDOI Listing

Neonatal bacterial meningitis versus ventriculitis: a cohort-based overview of clinical characteristics, microbiology and imaging.

Eur J Pediatr 2020 Jul 3. Epub 2020 Jul 3.

Department of Neonatal Intensive Care, Amsterdam University Medical Centre, Amsterdam, Netherlands.

Central nervous system (CNS) infections are potentially life threatening in neonates and can lead to the ill-defined diagnosis of ventriculitis. With this study we aimed to explore and describe ventriculitis regarding clinical, microbiological and ultrasonographic characteristics. We performed a retrospective cohort study including all neonates with a culture-proven CNS infection admitted to our tertiary NICU over a 12-year period (2004-2016). Read More

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http://dx.doi.org/10.1007/s00431-020-03723-3DOI Listing

Mullen Scales of Early Learning Adaptation for Assessment of Indian Children and Application to Tuberculous Meningitis.

J Trop Pediatr 2020 Jul 4. Epub 2020 Jul 4.

Department of Rehabilitation Psychology and Neuropsychology, The Institute for Rehabilitation and Research (TIRR) Memorial Hermann, Houston, TX, USA.

Introduction: Tuberculous meningitis (TBM) results in significant morbidity and mortality among children worldwide. Associated neurocognitive complications are common but not well characterized. The Mullen Scales of Early Learning (MSEL), a well-established measure for assessment of neurodevelopment, has not yet been adapted for use in India. Read More

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http://dx.doi.org/10.1093/tropej/fmaa034DOI Listing