Search Our Scientific Publications & Authors

Neurosurg Rev 2022 May 27. Epub 2022 May 27.

Department of Pharmacy, Uzhhorod National University, Uzhhorod, Ukraine.

Sphenoidal meningiomas constitute 18% of intracranial masses, and still present a difficult surgical challenge. PTBE has been associated with several complications and future recurrence. This study aims to evaluate the outcome of the operatively treated sphenoid wing meningiomas in relation to PTBE as a prognostic factor in a series of 65 patients. Read More

Cancers (Basel) 2022 May 6;14(9). Epub 2022 May 6.

Department of Neurosurgery, University of Marburg, 35037 Marburg, Germany.

Background: The aim of surgery for skull base meningiomas is maximal resection with minimal damage to the involved cranial nerves and cerebral vessels; thus, implementation of technologies for improved orientation in the surgical field, such as neuronavigation and augmented reality (AR), is of interest.

Methods: Included in the study were 39 consecutive patients (13 male, 26 female, mean age 64.08 ± 13. Read More

Cancers (Basel) 2022 Apr 28;14(9). Epub 2022 Apr 28.

Department of Neurosurgery, Medical Centre-University of Freiburg, 79106 Freiburg, Germany.

Objective: Medial sphenoid wing meningiomas are among the three most common intracranial meningiomas. These tumors pose a challenge to neurosurgeons in terms of surgical treatment, as they may involve critical neurovascular structures and invade the cavernous sinus. In case of the latter, a complete resection may not be achievable. Read More

Am J Ophthalmol Case Rep 2022 Jun 23;26:101556. Epub 2022 Apr 23.

Department of Ophthalmology, Weill Cornell Medical College, New York, NY, USA.

Purpose: To report a case of multilayered intraocular hemorrhage at the posterior pole as a complication of transorbital neuroendoscopic surgery.

Observations: Our patient underwent an uncomplicated endoscopic transorbital resection of a left sphenoid wing meningioma. In the immediate post-operative period, the patient reported blurred vision of her left eye, and dilated fundus examination demonstrated multilayered hemorrhages at the posterior pole. Read More

Surg Neurol Int 2022 31;13:113. Epub 2022 Mar 31.

Department of Neurology and Neurosurgery, Universidade Federal de São Paulo.

Background: Sphenoid wing meningiomas present close contact with intracranial arteries and have great potential for vascular complications. Here, we describe the case of a patient who presented a medial left giant lesser sphenoid wing meningioma involving the supraclinoid carotid artery. One week after surgery, she developed vasospasm whose treatment using milrinone achieved excellent results. Read More

Life (Basel) 2022 Mar 24;12(4). Epub 2022 Mar 24.

Department of Neurosurgery, Neurosurgery Clinic, Birgunj 44300, Nepal.

(1) Background: Meningiomas are usually benign encapsulated intracranial tumors with well-defined borders that offer a high chance of cure with complete removal. The aim of this study was to evaluate the association between preoperative MRI features and surgical plane of cleavage. (2) Materials and Methods: This was a cross-sectional observational study conducted in the Department of Neurosurgery, Bangabandhu Sheikh Mujib Medical University. Read More

World Neurosurg 2022 Jul 16;163:e635-e646. Epub 2022 Apr 16.

The Center for Neurosurgery and Skull Base Surgery, Hospital Ernesto Dornelles, Porto Alegre, Brazil.

Background: Sphenoid wing meningiomas with cavernous sinus invasion (SWMCSI) are challenging tumors. The preservation of quality of life and cranial nerve function is one of the most relevant aspects of treating patients with SWMCSI.

Methods: A retrospective study was conducted for surgery performed between 2008 and 2021, including 36 patients presenting with SWMCSI. Read More

Radiol Case Rep 2022 Apr 19;17(4):1325-1329. Epub 2022 Feb 19.

Department of Neurosurgery, UHC Habib Bourguiba, Sfax, Tunisia.

Giant intracranial aneurysms are defined as those with diameters of 25 mm or more and represent about 5% of all intracranial aneurysms. These aneurysms typically manifest during the fifth to seventh decades of life. Due to their size, giant aneurysms are responsible for intracranial mass effect rather than hemorrhage. Read More

J Korean Neurosurg Soc 2022 May 3;65(3):449-456. Epub 2022 Mar 3.

Department of Neurosurgery, Severance Hospital, Yonsei University, Seoul, Korea.

Objective: The aim of this study was to evaluate the clinical outcome of sphenoid wing meningioma with periorbital invasion (PI) after operation.

Methods: Sixty one patients with sphenoid wing meningioma were enrolled in this study. Their clinical conditions were monitored after the operation and followed up more than 5 years at the outpatient clinic of a single institution. Read More

Ann Med Surg (Lond) 2022 Feb 28;74:103322. Epub 2022 Jan 28.

Department of Radiation Oncology, King Hussein Cancer Center, Amman, Jordan.

Introduction And Importance: En-plaque-meningioma (EPM) is characterized by its flat growth along the bony contour. It accounts for 2-9% of all meningiomas. Very few grade II or III EPM cases were reported. Read More

Front Oncol 2021 2;11:771431. Epub 2021 Dec 2.

Department of Neurosurgery in Xiangya Hospital, Central South University, Changsha, China.

Objective: Parasellar meningiomas (PMs) represent a cohort of skull base tumors that are localized in the parasellar region. PMs tend to compress, encase, or even invade the cerebral arteries and their perforating branches. The surgical resection of PMs without damaging neurovascular structures is challenging. Read More

Wiad Lek 2021 ;74(10 cz 2):2678-2681

UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE.

Peritumoral brain edema (PTBE) is seen in 40-78% of all cases of intracranial meningiomas. It may vary in shape and size, occasionally being two to three times larger than the tumor. We present a case of a 62-year-old female patient, suffering from seizure and progressive headache. Read More

Cureus 2021 Nov 6;13(11):e19323. Epub 2021 Nov 6.

Department of Ophthalmology, Hospital Bintulu, Bintulu, MYS.

We report a case of a 43-year-old woman with an underlying right sphenoid wing meningioma (SWM) who complained of increased right eye swelling, proptosis, redness and severe pain for two weeks. Her symptoms started one week after completing radiotherapy. She seeked treatment after a worsening of symptoms. Read More

Cir Cir 2021 ;89(S1):66-69

Department of Functional Neurosurgery, Stereotactic and Radiosurgery, Hospital General de México.

Meningiomas are the most frequent extra-axial tumors of the nervous system. Multiple meningiomas are defined as the presence of two or more lesions that appear simultaneously or not, in different intracranial location, without association to neurofibromatosis. Each lesion must be evaluated individually for treatment, which consists in microsurgical resection in most cases. Read More

J Neurol Surg B Skull Base 2021 Dec 2;82(6):624-630. Epub 2021 Mar 2.

Department of Neurosurgery, National Neurosciences Institute, King Fahad Medical City, Riyadh, Saudi Arabia.

 Medial sphenoid wing meningiomas (MSWMs) account for approximately 20% of all meningiomas that are known for their critical relation to neurovasculture structures.  The purpose of this study is to examine the relation between the maximum diameter of the MSWM medial to the anterior clinoidal line (AC line) and surgical outcome.  This is a retrospective cohort study investigating all surgically resected MSWM cases at our institution over 10 years. Read More

J Craniofac Surg 2022 May 5;33(3):901-905. Epub 2021 Nov 5.

Department of Neurosurgery, The Ninth People's Hospital Affiliated to Shanghai Jiao Tong University Medical College, Shanghai, China.

Objective: The extensive bone infiltration and carpet-like growth characteristics of spheno-orbital meningioma (SOM) make it hard to remove entirely, and recurrence and proptosis are the main reasons for reoperation. The authors report 20 cases of surgical treatment for recurrence of SOM, including surgical technique and symptom improvement.

Methods: The clinical data and follow-up results of 20 cases of recurrent SOM at our institution from 2000 to 2017 were retrospectively analyzed. Read More

Surg Neurol Int 2021 13;12:459. Epub 2021 Sep 13.

Department of Neurosurgery Baylor College of Medicine, Houston, Texas, United States.

Background: Oscillopsia is a visual phenomenon in which an individual perceives that their environment is moving when it is in fact stationary. In this report, we describe two patients with pulsatile oscillopsia following orbitocranial approaches for skull base meningioma resection.

Case Description: Two patients, both 42-year-old women, underwent orbitocranial approaches for resection of a right sphenoid wing (Patient 1) and left cavernous sinus (Patient 2) meningioma. Read More

J Craniofac Surg 2022 May 29;33(3):859-862. Epub 2021 Sep 29.

Stein Eye Institute, Department of Ophthalmology, UCLA.

Objective: To describe the clinical features and outcomes of patients who underwent transorbital debulking of sphenoid wing meningioma.

Methods: Patients with a diagnosis of sphenoid wing meningioma who underwent transorbital debulking were included in this series. Preoperative and postoperative symptoms and examination findings, including best corrected visual acuity (BCVA) and proptosis were extracted from patient charts. Read More

Graefes Arch Clin Exp Ophthalmol 2022 Feb 23;260(2):577-581. Epub 2021 Sep 23.

Centre for Ophthalmology, University of Tuebingen, Elfriede-Aulhorn-Str. 7, 72076, Tuebingen, Germany.

Background/objectives: The correct classification of a slowly progressing optic atrophy can be challenging. The aim of this work was to find out if the characteristics of peripapillary retinal nerve fiber layer (RNFL) thickness loss differ between open angle glaucoma (POAG), optic nerve sheath meningioma (ONSM), and sphenoid wing meningioma (SWM).

Methods: A total of 45 patients with POAG, ONSM, and SWM were included in the retrospective study. Read More

Acta Neurochir (Wien) 2021 12 16;163(12):3387-3400. Epub 2021 Aug 16.

Department of Neurosurgery, University Hospital of Lausanne and Faculty of Biology and Medicine, University of Lausanne, Rue du Bugnon 46, CH-1011, Lausanne, Switzerland.

Background: The optimal management of clinoidal meningiomas (CMs) continues to be debated.

Methods: We constituted a task force comprising the members of the EANS skull base committee along with international experts to derive recommendations for the management of these tumors. The data from the literature along with contemporary practice patterns were discussed within the task force to generate consensual recommendations. Read More

J Neurooncol 2021 Sep 4;154(2):237-246. Epub 2021 Aug 4.

Department of Neurosurgery, Yale School of Medicine, 15 York St, LLCI 810, New Haven, CT, 06520-8082, USA.

Purpose: As sphenoid wing meningiomas (SWMs) are associated with varying degrees of bony involvement, we sought to understand potential relationships between genomic subgroup and this feature.

Methods: Patients treated at Yale-New Haven Hospital for SWM were reviewed. Genomic subgroup was determined via whole exome sequencing, while the extent of bony involvement was radiographically classified as no bone invasion (Type I), hyperostosis only (Type II), tumor invasion only (Type III), or both hyperostosis and tumor invasion (Type IV). Read More

World Neurosurg 2021 10 31;154:e665-e670. Epub 2021 Jul 31.

Department of Neurosurgery, Center for Neurosurgery, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany.

Background: Meningioma is the most common primary brain tumor in adults. In recent years, several non-neurofibromin 2 mutations, i.e. Read More

J Neurol Surg B Skull Base 2021 Jul 23;82(Suppl 3):e33-e44. Epub 2019 Dec 23.

Department of Neurological Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States.

 En plaque meningiomas are a rare subtype of meningiomas that are frequently encountered in the spheno-orbital region. Characterized by a hyperostotic and dural invasive architecture, these tumors present unique diagnostic and treatment considerations.  The authors conduct a narrative literature review of clinical reports of en plaque meningiomas to summarize the epidemiology, clinical presentation, diagnostic criteria, and treatment considerations in treating en plaque meningiomas. Read More

BMJ Case Rep 2021 Jul 14;14(7). Epub 2021 Jul 14.

Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, UK.

We present a 69-year-old transgender woman who underwent gender-affirming surgery in 1998 and gender-affirming hormone therapy (cyproterone acetate (CPA) and estradiol) since this time. Following an MRI scan to investigate tremor in 2013, an incidental left anterior clinoid and right petrous meningioma were identified. Subtotal surgical resection was achieved for the anterior clinoid meningioma (WHO grade 1, meningothelial subtype). Read More

Front Oncol 2021 4;11:672228. Epub 2021 Jun 4.

Department of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany.

Objective: Spheno-orbital meningiomas (SOM) are rare intracranial tumors that arise at the sphenoid wing. These tumors can invade important neurovascular structures making radical resection difficult, while residual tumors often lead to recurrence. The purpose of this study was to evaluate prognostic factors influencing the recurrence and progression-free survival (PFS) rates of spheno-orbital meningiomas, with a particular focus on the role of surgery and postoperative radiotherapy. Read More

Clin Nucl Med 2021 Nov;46(11):922-923

Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.

Abstract: 68Ga-DOTATOC PET/CT is a reliable imaging modality in the diagnosis and therapy planning of symptomatic meningiomas. We present a case of a 74-year-old woman where a supposed SSTR-positive sphenoid wing meningioma turned out to be a breast cancer metastasis. Our case shows that dural metastases from breast cancer might represent a clinical pitfall in 68Ga-DOTATOC PET/CT. Read More

Neurochirurgie 2021 Nov 26;67(6):547-555. Epub 2021 May 26.

Department of Neurosurgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 52242 Iowa City, Iowa, USA. Electronic address:

Background: Sphenoid wing meningiomas are a challenging surgical disease with relatively high perioperative morbidity. Most studies to date have focused on resection strategies as it relates to disease recurrence. Few have examined the optimal strategy as it relates to overall patient survival. Read More

World Neurosurg 2021 07 22;151:44-51. Epub 2021 Apr 22.

Department of Neurosurgery, Instituto de Neurologia de Curitiba, Curitiba, Paraná, Brazil.

Background: Single-stage surgical treatment of cranial intraosseous meningiomas includes complete tumor resection followed by aesthetic reconstruction. Tailored tumor resection with a computer-aided design/computer-aided manufacturing custom-made implant for the defect has been advocated in recent years to achieve a satisfactory cosmetic result with reduced operative time and fewer complications. However, several technical nuances related to the area of osseous removal may compromise cranioplasty. Read More

Ocul Oncol Pathol 2021 Mar 30;7(1):54-61. Epub 2020 Nov 30.

Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, United Kingdom.

Purpose: To describe our experience in performing biopsy of post-septal orbital masses with core needle under computerized tomography guidance (CT-CNB).

Methods: The medical records of all patients who underwent this procedure were reviewed. The procedure was performed under local anesthesia on a day case basis under a peribulbar block. Read More

Ophthalmic Plast Reconstr Surg 2021 Nov-Dec 01;37(6):522-533

Orbital Plastic and Lacrimal Clinic, Royal Victorian Eye and Ear Hospital.

Purpose: To review the imaging features of the broad range of nonmeningioma lesions of the greater wing of the sphenoid (GWS) bone and adjacent orbit to assist clinicians in differentiating these lesions from each other and from the most common lesion of the GWS and adjacent orbit, meningioma.

Methods: We reviewed 32 cases of spheno-orbital lesions involving the GWS from our own practice, as well as 109 published cases (total 141), with emphasis on available imaging features on computerized tomography (CT) and MRI. Features that might assist in differentiating meningioma from its mimics were analyzed for each lesion, including the presence of an osteoblastic or hyperostotic response, bone erosion or osteolysis, homogeneous hypo- or hyperintensity on T2-weighted MRI, leptomeningeal involvement, and the absence of a "dural tail" on contrast-enhanced MRI. Read More