361 results match your criteria Meningioma Optic Nerve Sheath


Effectiveness and Safety of Robotic Radiosurgery for Optic Nerve Sheath Meningiomas: A Single Institution Series.

Cancers (Basel) 2021 Apr 30;13(9). Epub 2021 Apr 30.

Charité Cyberknife Center, Augustenburger Platz 1, 13353 Berlin, Germany.

The role of robotic radiosurgery (RRS) in the treatment of optic nerve sheath meningiomas (ONSM) remains controversial and it is only performed in specialized institutions due to tight dose constraints. We evaluated the effectiveness and safety of RRS in the management of ONSM. Twenty-five patients with 27 ONSM lesions who underwent RRS using the Cyberknife (CK) system were retrospectively analyzed (median age, 47. Read More

View Article and Full-Text PDF

Surgical Treatment of Bilateral Optic Nerve Sheath Meningioma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 May 3. Epub 2021 May 3.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Even though intracranial meningiomas commonly invade the optic canals, true optic nerve sheath meningiomas are extremely rare. They are insidious lesions that frequently grow in 4 stages, leading to progressive visual loss.1-4  Frequently, management includes observation for asymptomatic patients, and fractioned stereotactic radiotherapy with progressive visual loss. Read More

View Article and Full-Text PDF

Uncovering an Optic Nerve Sheath Meningioma Using 68Ga-DOTATATE PET/CT.

Clin Nucl Med 2021 Apr 5. Epub 2021 Apr 5.

From the Departments of Neurology Diagnostic and Interventional Radiology Nuclear Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne Institute of Neuroscience and Medicine, Research Center Juelich, Juelich Center for Integrated Oncology, Universities of Aachen, Bonn, Cologne, and Düsseldorf, Cologne, Germany.

Abstract: A 56-year-old woman was initially diagnosed with optic neuritis. However, several "red flags" were present: older age at presentation, no multiple sclerosis suspicious findings on MRI, and negative oligoclonal bands. 68Ga-DOTATATE PET/CT confirmed the differential diagnosis of an optic sheath meningioma. Read More

View Article and Full-Text PDF

Approach to patient with unilateral optic disc edema and normal visual function.

J Neurol Sci 2021 May 24;424:117414. Epub 2021 Mar 24.

University of Toronto, Faculty of Medicine, Department of Ophthalmology and Vision Sciences, Toronto, Ontario, Canada; University of Toronto, Faculty of Medicine, Department of Medicine, Division of Neurology, Toronto, Ontario, Canada. Electronic address:

In patients with swollen optic nerve head and normal visual function, optic disc drusen (ODD) is the most common diagnosis. The best tests for detecting ODD are funds autofluorescence and enhanced-depth imaging ocular coherence tomography (EDIOCT). After ODD has been ruled out, asymmetric papilledema should be assumed to be the cause and MRI of the brain and orbits with contrast and venography should be performed in all patients. Read More

View Article and Full-Text PDF

Gaze-evoked amaurosis from idiopathic orbital inflammation.

Orbit 2021 Mar 29:1-4. Epub 2021 Mar 29.

Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, Canada.

Gaze-evoked amaurosis is a transient monocular vision loss elicited by eccentric gaze and has been reported in many orbital conditions but is most classically associated with intraconal tumors, such as cavernous hemangioma and optic nerve sheath meningioma. Here, the authors report a case of gaze-evoked amaurosis due to idiopathic orbital inflammation. The patient was a 35-year-old man who presented with vision loss only when abducting his left eye. Read More

View Article and Full-Text PDF

Primary and Secondary Optic Nerve Sheath Meningioma.

J Neurol Surg B Skull Base 2021 Feb 18;82(1):27-71. Epub 2021 Feb 18.

Divisions of Neuro-ophthalmology and Oculoplastics/Orbital Surgery, Department of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, New Jersey, United States.

 This study was aimed to review issues relating to the recognition, radiographic diagnosis, monitoring, and management of primary and secondary optic nerve sheath meningioma (ONSM).  This study is a review of peer-reviewed literature combined with illustrative case studies.  A literature search was conducted via the PubMed database using pertinent search terms. Read More

View Article and Full-Text PDF
February 2021

Case report Ga-DOTATATE of optic nerve sheath meningioma.

Am J Ophthalmol Case Rep 2021 Jun 5;22:101048. Epub 2021 Mar 5.

Department of Radiology, University of California, San Diego, United States.

We report a patient with an optic nerve sheath meningioma whose diagnosis and management were guided by using Gallium-68 DOTA-Tyr-octreotatate (Ga-DOTATATE). Positron Emission Tomography-Computed Tomography (PET-CT). Read More

View Article and Full-Text PDF

Prognostic Factors for Functional Outcome of Patients with Optic Nerve Sheath Meningiomas Treated with Stereotactic Radiotherapy-Evaluation of Own and Meta-Analysis of Published Data.

Cancers (Basel) 2021 Jan 29;13(3). Epub 2021 Jan 29.

Department of Radiosurgery and Stereotactic Radiotherapy, MediClin Robert Janker Clinic and MediClin MVZ Bonn, Villenstrasse 8, 53129 Bonn, Germany.

Objective: To evaluate prognostic factors for a favorable outcome (improvement of the visual acuity or visual fields) after fractionated stereotactic radiotherapy (fSRT) of optic nerve sheath meningioma (ONSM).

Methods: We performed a database search for ONSM treatments during the period from April 2008 to September 2019 in the prospective database for stereotactic radiosurgery/radiotherapy (SRS/SRT) of the Robert Janker Clinic Bonn (Department of Radiotherapy) and performed a literature review and meta-analysis of published data on ONSM between 2010 and 2019. Ophthalmic status before and after treatment was evaluated and the collective was dichotomized into two groups: functional improvement (FI; improvement of either visual acuity or visual fields) and non functional improvement (NFI; with stable or deteriorating visual acuity or visual fields). Read More

View Article and Full-Text PDF
January 2021

Unilateral Isolated Paucisymptomatic Optic Disc Edema.

J Neuroophthalmol 2020 Dec 22;Publish Ahead of Print. Epub 2020 Dec 22.

Departments of Ophthalmology (EH, RAS, JHP, MD, NJN, VB), Pediatrics (JHP), Neurology (NJN, VB), and Neurological Surgery (NJN), Emory University School of Medicine, Atlanta, Georgia.

Background: Unilateral isolated optic disc edema (UIODE) represents a challenging clinical presentation that frequently precipitates an extensive diagnostic work-up. Patients without an apparent diagnosis despite appropriate investigations are often categorized as having "papillophlebitis," an entity that is poorly defined in the existing literature. Our aim was to describe the characteristics of a series of patients with paucisymptomatic UIODE, determine the optimal diagnostic approach to such cases, and clarify the clinical features of presumed papillophlebitis. Read More

View Article and Full-Text PDF
December 2020

An Atypical Paediatric Optic Nerve Sheath Meningioma.

Neuroophthalmology 2020 24;44(6):403-406. Epub 2020 Jun 24.

Department of Radiology, Uludag University, Bursa, Turkey.

A 16-year-old male presented with a three year history of right proptosis. All other ocular findings were normal. Imaging demonstrated a large, calcified, contrast-enhancing mass in the apical orbit. Read More

View Article and Full-Text PDF

The Coexistence of Olfactory Groove with Optic Nerve Sheath Meningioma Presenting with Anosmia: Case Report.

Curr Med Imaging 2020 Nov 24. Epub 2020 Nov 24.

Department of Neurology, Ankara Yıldırım Beyazıt University, Ankara. Turkey.

Introduction: Meningiomas are the third most common intracranial tumors in adults after glial tumors and metastases. Olfactory groove meningiomas often grow without symptoms due to their slow growth rates and location in the frontal lobe. Optic nerve sheath meningiomas are benign neoplasms of the meninges surrounding the optic nerve. Read More

View Article and Full-Text PDF
November 2020

Optimal management in optic nerve sheath meningioma - A multicentre study and pooled data analysis.

J Clin Neurosci 2020 Oct 19;80:162-168. Epub 2020 Aug 19.

Save Sight Institute, Faculty of Health and Medicine, The University of Sydney, Australia; Dept of Ophthalmology, Macquarie University, Macquarie, NSW, Australia.

Optic nerve sheath meningiomas (ONSMs) are rare, benign neoplasms of the anterior visual pathway. The optimal modality of radiotherapy for treatment has not yet been established. This is the first study to show significant difference in visual outcomes between radiotherapy subtypes in the management of ONSM. Read More

View Article and Full-Text PDF
October 2020

Atypical acute presentation of an optic nerve sheath meningioma.

Am J Ophthalmol Case Rep 2020 Dec 29;20:100951. Epub 2020 Sep 29.

Dell Medical School, University of Texas at Austin, 1501 Red River St, Austin, TX, 78712, USA.

Purpose: Primary optic nerve sheath meningiomas (ONSM) are benign lesions that typically present with findings of painless proptosis (59%), optic nerve pallor (55%), and decreased peripheral vision (35%). Herein we share an atypical case of a patient who presented acutely with periorbital pain and optic nerve head edema, and was ultimately determined to have a low-grade optic nerve meningioma.

Observations: A 36-year-old healthy woman presented with acute onset of left periorbital discomfort. Read More

View Article and Full-Text PDF
December 2020

Optic nerve sheath meningioma.

Curr Opin Ophthalmol 2020 Nov;31(6):455-461

Department of Neuro-Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: Optic nerve sheath meningiomas (ONSMs) are rare benign tumors of the anterior visual pathway which present with slowly progressive and painless vision loss and account for approximately 2% of all orbital tumors. This article provides an overview as well as an update on the ONSMs with regards to cause, epidemiology, clinical presentation, diagnosis, and management in adults and pediatric population.

Recent Findings: The clinical presentation and prognosis of ONSMs can vary and largely depend on the location of tumor as well as the histologic type. Read More

View Article and Full-Text PDF
November 2020

Results of Neuroimaging in Patients with Atypical Normal-Tension Glaucoma.

Biomed Res Int 2020 18;2020:9093206. Epub 2020 Aug 18.

Department of Diagnostics and Microsurgery of Glaucoma, Medical University of Lublin, Lublin, Poland.

Aim: The aim of the study was to determine the frequency of pathologies which can mimic normal-tension glaucoma (NTG), observed in neuroimaging of NTG patients, and to evaluate the frequency of pathologies in determined additional indications for neuroimaging. . The studied group consisted of 126 NTG patients who met at least one of the following criteria: unilateral NTG, damage in the visual field (VF) inconsistent with optic disc appearance, fast VF progression, worsening of visual acuity, predominant optic disc pallor rather than optic disc excavation, diagnosis under the age of 50, and scotoma in VF restricted by a vertical line. Read More

View Article and Full-Text PDF

Optical Coherence Tomography Angiography Findings in Optic Nerve Sheath Meningioma.

Case Rep Ophthalmol 2020 May-Aug;11(2):364-369. Epub 2020 Jul 14.

Department of Ophthalmology, "Santo Spirito" Hospital, Pescara, Italy.

A 46-year-old female with a history of 5 months of progressive painless visual loss in the left eye was found to have an optic nerve sheath meningioma. Optical coherence tomography angiography showed a reduction in the superficial capillary plexus density consistent with her visual field defect and peripapillary retinal nerve fiber layer thinning. Moreover, abnormalities in the choriocapillaris were found in the affected eye compared to the fellow eye. Read More

View Article and Full-Text PDF

The Role of Neuro-Ophthalmologists in the Care of Patients With Neurofibromatosis Type 2.

Authors:
Klara Landau

J Neuroophthalmol 2020 Sep;40 Suppl 1:S51-S56

Department of Opthalmology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.

Neurofibromatosis type 2 (NF2) is a rare genetic disorder, affecting the central nervous system and leading to various degrees of disability. Its hallmark is bilateral vestibular schwannomas that invariably lead to progressive hearing loss. Specific ophthalmic abnormalities in patients with NF2 may help to establish an early diagnosis. Read More

View Article and Full-Text PDF
September 2020

Diosgenin inhibits the proliferation, migration and invasion of the optic nerve sheath meningioma cells via induction of mitochondrial-mediated apoptosis, autophagy and G0/G1 cell cycle arrest.

J BUON 2020 Jan-Feb;25(1):508-513

Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China, 430060.

Purpose: Diosgenin - a steroidal saponin- has been shown to exhibit wonderful anticancer potential. However, the antiproliferative effects of diosgenin have not been examined against the optic nerve sheath meningioma cells. In the current research work, the anticancer potential of diosgenin was evaluated in optic nerve sheath meningioma cells along with evaluating its effects on cancer cell invasion, migration, apoptotic cell death, autophagy and cell cycle progression. Read More

View Article and Full-Text PDF
December 2020

Optic nerve sheath meningioma-findings in the contralateral optic nerve tract: A case report.

Mol Clin Oncol 2020 May 5;12(5):411-414. Epub 2020 Mar 5.

JL Clinic, Prague 15800, Czech Republic.

The aim of the present study was to observe visual pathway changes on the contralateral side in optic nerve sheath meningioma (ONSM). The authors present a case report of a 43-year-old patient with OfNSM on the right side. A complex ophthalmic examination was performed, including an assessment of visual functions, an electrophysiology examination and functional and structural MRI examinations. Read More

View Article and Full-Text PDF

Dilation of the Perioptic Subarachnoid Space Anterior to Optic Nerve Sheath Meningioma.

J Neuroophthalmol 2021 Mar;41(1):e100-e102

Department of Ophthalmology (ACA), Stein Eye Institute, University of California, Los Angeles; Department of Ophthalmology (AGL), Houston Methodist Hospital, Houston, Texas; Baylor College of Medicine (AGL), The Baylor Center for Space Medicine, Houston, Texas; Departments of Ophthalmology, Neurology, and Neurosurgery (AGL), Weill Cornell Medical College, New York, New York; Department of Ophthalmology (AGL), The University of Texas Medical Branch, Galveston, Texas; Department of Ophthalmology (AGL), The University of Iowa Hospitals and Clinics, Iowa City, Iowa; and The UT MD Anderson Cancer Center (AGL), Houston, Texas.

View Article and Full-Text PDF

Retrospective analysis of fractionated intensity-modulated radiotherapy (IMRT) in the interdisciplinary management of primary optic nerve sheath meningiomas.

Radiat Oncol 2019 Dec 27;14(1):240. Epub 2019 Dec 27.

Department of Radiation Oncology, Eberhard-Karls-University Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.

Background: As optic nerve sheath meningiomas (ONSM) are rare, there are no prospective studies. Our retrospective analysis focusses on a cohort of patients with uniform disease characteristics all treated with the same radiotherapy regimen. We describe treatment decision making, radiotherapy planning and detailed neuro-ophthalmological outcome of the patients. Read More

View Article and Full-Text PDF
December 2019

Endoscopic orbital decompression for proptosis in non-thyroid eye disease.

Oral Maxillofac Surg 2020 Mar 19;24(1):85-91. Epub 2019 Dec 19.

Department of Ophthalmology, Sussex Eye Hospital, Eastern Road, Brighton, BN2 5BF, UK.

Purpose: Orbital decompression is an established surgical treatment option for a range of orbital conditions. We report the outcomes of endonasal decompression to recess the globe for conditions and pathologies other than thyroid eye disease.

Methods: This was a retrospective case series of patients who underwent endoscopic orbital decompression for proptosis secondary to non-thyroid eye disease orbital pathologies. Read More

View Article and Full-Text PDF

Antitumor effects of Farnesol in optic nerve sheath meningioma cell line and its effects on cell cycle progression, autophagy, cell migration and invasion.

J BUON 2019 Sep-Oct;24(5):2168-2172

Department of Ophthalmology, West China Hospital, Si Chuan University, Sichuan 610041, China.

Purpose: Farnesol has been shown to exhibit important anticancer potential. However, its antiproliferative effects have not been examined against the optic nerve sheath meningioma cells. In this study the potential of Farnesol in the treatment of optic nerve meningioma was evaluated by examining its antiproliferative effects against the HBL-52 cells. Read More

View Article and Full-Text PDF

Cerebrospinal fluid and optic nerve sheath compartment syndrome: A common pathophysiological mechanism in five different cases?

Clin Exp Ophthalmol 2020 03 11;48(2):212-219. Epub 2019 Nov 11.

Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.

Importance: Optic nerve (ON) dysfunction is a common feature of different diseases. The pathophysiology is not yet fully understood.

Background: This study describes five patients with ON sheath (ONS) compartment syndrome (ONSCS) and contributes to the hypothesis that impaired cerebrospinal fluid (CSF) flow can play a role in the development of ON dysfunction. Read More

View Article and Full-Text PDF

Pneumosinus Dilatans: An exploration into the association between Arachnoid Cyst, Meningioma and the pathogenesis of Pneumosinus Dilatans.

Clin Neurol Neurosurg 2019 Oct 14;185:105462. Epub 2019 Aug 14.

University Hospitals Coventry & Warwickshire Trust, Clifford Bridge Road, Coventry, CV2 2DX, United Kingdom.

Objectives: To investigate the association between certain intracranial masses (meningioma and arachnoid cyst) and the incidence of Pneumosinus Dilatans (PSD) - including whether the size of the mass correlates with severity of the condition.

Patients And Methods: A review of the available case reports on PSD was performed. Clinical data was extracted from 111 case reports for analysis. Read More

View Article and Full-Text PDF
October 2019

Neurofibromatosis type 2 and related disorders.

Curr Opin Oncol 2019 11;31(6):562-567

Genomic Medicine, Division of Evolution and Genomic Sciences, MAHSC, University of Manchester, St Mary's Hospital, Manchester, UK.

Purpose Of Review: Neurofibromatosis type 2 (NF2) is a schwannoma predisposition syndrome, alongside schwannomatosis related to germline LZTR1 and SMARCB1 pathogenic variants. This review highlights their overlapping phenotypes, new insight into NF2 phenotype and treatment outcomes.

Recent Findings: Mosaic NF2 is more prevalent than previously thought. Read More

View Article and Full-Text PDF
November 2019

Long-term treatment outcomes of patients with primary optic nerve sheath meningioma treated with stereotactic radiotherapy.

J Clin Neurosci 2019 Oct 7;68:162-167. Epub 2019 Aug 7.

Epworth Radiation Oncology, Melbourne, Victoria, Australia.

We analysed the long-term outcomes of patients with primary optic nerve sheath meningioma (ONSM) treated with stereotactic radiotherapy (SRT). 26 patients with primary ONSM were treated with SRT between 2004 and 2013 at a single institution. SRT was delivered with image guidance to a median dose of 50. Read More

View Article and Full-Text PDF
October 2019