379 results match your criteria Meningioma Optic Nerve Sheath


somatic mosaicism in a patient with bilateral optic nerve sheath meningiomas: illustrative case.

J Neurosurg Case Lessons 2022 Jun 6;3(23):CASE2247. Epub 2022 Jun 6.

Departments of Ophthalmology.

Background: In the past decade, next-generation sequencing has spurred significant progress in the understanding of cytogenetic alterations that occur in meningiomas. Eighty percent of adult meningiomas harbor pathogenic somatic variants involving , , , , , or Somatic variants in associated with meningiomas usually localize to the gene's WD40 domains but are mutually exclusive to germline mutations, which cause a distinctive autosomal dominant syndrome.

Observations: This case involved a 15-year-old girl with bilateral optic nerve sheath meningiomas, diffuse meningiomatosis, and syndromic features, including craniosynostosis, brain anomalies, syndactyly, brachydactyly, epicanthus, and patent ductus arteriosus. Read More

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Radiotherapy and Radiosurgery in the Management of Optic Nerve Sheath Meningiomas: An International Systematic Review and Meta-Analysis of Twenty Studies.

World Neurosurg 2022 May 21. Epub 2022 May 21.

Department of Radiation Oncology, Mayo Clinic, Jacksonville, Florida, USA.

Background: Optic nerve sheath meningiomas (ONMs) are often managed with radiotherapy (RT) with the goal of achieving radiographic local control (LC) and preventing deterioration of visual acuity (VA). We aimed to perform a systematic review and meta-analysis of outcomes for patients with ONM treated with RT.

Methods: The PICOS/PRISMA/MOOSE selection criteria were used to identify studies. Read More

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Investigating the number of radiation fields in intensity-modulated radiotherapy plans of optic nerve sheath meningioma patients using dose gradient index.

Biomed Phys Eng Express 2022 Mar 23. Epub 2022 Mar 23.

Radiation Oncology Department, Isfahan Milad Hospital, Shahrak-e Valieasr (Keshavarz Blvd), Isfahan, Isfahan, 8179663467, Iran (the Islamic Republic of).

In optic nerve radiotherapy, vital organs are very close to the target volume, they are highly sensitive to radiation and have low dose tolerance. In this regard, evaluating dose fall-off steepness around the target volume is required to assess various intensity-modulated radiation therapy (IMRT) plans in the treatment of the optic nerve sheath meningioma (ONSM) patients.Thirteen ONSM patients were analyzed with three IMRT techniques, including three (IMRT-3F), five (IMRT-5F), and seven fields (IMRT-7F). Read More

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Imaging Findings of Pediatric Orbital Masses and Tumor Mimics.

Radiographics 2022 May-Jun;42(3):880-897. Epub 2022 Mar 4.

From the Departments of Radiology (A.K.J., J.B.G., L.J.E., G.B.L., J.C.B., W.B., V.M.S.), Ophthalmology (L.A.D.), Neurology (G.F.K.), Neurosurgery (W.B.), and Radiation Oncology (N.N.L.), Mayo Clinic, 200 1st St SW, Rochester, MN 55905.

Pediatric orbital masses are not common but encompass a wide spectrum of benign and malignant entities that range from developmental anomalies to primary and secondary orbital malignancies and metastatic disease. Certain orbital tumors are unique to pediatric patients, such as retinoblastoma and neuroblastoma. Clinical symptoms and signs are often insufficient to differentiate between orbital lesions, and imaging is essential for narrowing the diagnostic considerations and determining the most appropriate management strategy. Read More

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Orbital indications.

Authors:
Jeremy C Ganz

Prog Brain Res 2022 14;268(1):315-327. Epub 2021 Dec 14.

Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway. Electronic address:

GKNS for uveal melanoma has become a recognized valued treatment which avoids enucleation of the eye. In the early days, the eccentric location of these tumors made treatment difficult, but Gamma Knife Perfexion has solved that problem. It is known that larger tumors and tumors with an anterior location have a worse prognosis. Read More

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Clinical, Pathologic, and Radiologic Features of Orbital Solitary Fibrous Tumors and Meningiomas.

Cureus 2021 Nov 17;13(11):e19678. Epub 2021 Nov 17.

Radiology, State University of New York Upstate Medical University, Syracuse, USA.

A wide variety of benign and malignant tumors can arise from different structures in the orbital and peri-orbital area, affecting the eye and the optic nerve. This spectrum of tumors includes primary and metastatic carcinomas, lymphomas, melanomas, soft tissue tumors, and primary tumors of the retina, optic disc, and optic nerve. These also extend to relatively rare entities such as solitary fibrous tumor and meningioma of the orbit and optic nerve, which can present with very similar clinical and radiologic features, although the tumor grades, treatment plans, and outcomes can vary widely. Read More

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November 2021

Neuroimaging Features of Optic Nerve Hemangioblastoma Identified by Conventional and Advanced Magnetic Resonance Techniques: A Case Report and Literature Review.

Front Oncol 2021 12;11:763696. Epub 2021 Nov 12.

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Optic nerve hemangioblastoma is a very rare benign tumor with only 39 reported cases by now. It appears to be hyperintense on T2-weighted images with a significant enhancement on contrast scans, which are similar to glioma and meningioma. Due to the lack of specificity in MRI manifestations, optic nerve hemangioblastoma is often misdiagnosed. Read More

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November 2021

Radiotherapy for the treatment of optic nerve sheath meningioma: A systematic review and meta-analysis.

Radiother Oncol 2021 12 21;165:135-141. Epub 2021 Oct 21.

Department of Ophthalmology, Otorhinolaryngology and Head Neck Surgery, Ribeirao Preto Medical School - University of São Paulo, Ribeirão Preto, Brazil.

Objectives: The management of Optic Nerve Sheath Meningiomas (ONSM) has suffered a significant shift due to new radiation techniques. However, there is no conclusive information on which approach presents better results in the literature. This meta-analysis aims to evaluate the outcomes of different radiotherapy (RT) modalities in the management of ONSM. Read More

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December 2021

Treatment of Recurrent Optic Nerve Sheath Meningioma With a Secondary Course of Radiotherapy.

Cureus 2021 Sep 13;13(9):e17935. Epub 2021 Sep 13.

Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, USA.

Optic nerve sheath meningiomas (ONSM) are benign neoplasms found surrounding the optic nerve that can affect vision, and potentially lead to blindness. The use of radiotherapy has been advocated to improve visual outcomes and minimize the risk of complications. We present a case of a 58-year-old woman who was treated with a second course of radiotherapy 27-years after initial radiotherapy for recurrent ONSM. Read More

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September 2021

Characteristics of peripapillary retinal nerve fiber layer atrophy in glaucoma, optic nerve sheath meningioma, and sphenoid wing meningioma.

Graefes Arch Clin Exp Ophthalmol 2022 Feb 23;260(2):577-581. Epub 2021 Sep 23.

Centre for Ophthalmology, University of Tuebingen, Elfriede-Aulhorn-Str. 7, 72076, Tuebingen, Germany.

Background/objectives: The correct classification of a slowly progressing optic atrophy can be challenging. The aim of this work was to find out if the characteristics of peripapillary retinal nerve fiber layer (RNFL) thickness loss differ between open angle glaucoma (POAG), optic nerve sheath meningioma (ONSM), and sphenoid wing meningioma (SWM).

Methods: A total of 45 patients with POAG, ONSM, and SWM were included in the retrospective study. Read More

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February 2022

Efficacy and Safety of Proton Beam Therapy for Primary Optic Nerve Sheath Meningioma.

Eye Brain 2021 24;13:219-229. Epub 2021 Aug 24.

Neurosurgery Department, Hôpital Fondation A. de Rothschild, Paris, France.

Purpose: Management of optic nerve sheath meningiomas (ONSM) remains challenging. Photon radiation therapy (PhRT) is the most common treatment for sight-threatening ONSM. Proton beam therapy (PBT) is less commonly used because it is more expensive and because there are questions about its efficacy specifically in relation to ONSM. Read More

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Salvage Radiosurgery for Optic Nerve Sheath Meningioma.

Cureus 2021 Jul 18;13(7):e16450. Epub 2021 Jul 18.

Neurological Surgery, Mayo Clinic, Rochester, USA.

Optic nerve sheath meningiomas (ONSMs) are rare and benign tumors that affect the optic nerve. Although surgical decompression may be used for large tumors that cause mass effect on the surrounding structures, the mainstay of treatment is radiotherapy. We report the case of a 54-year-old female patient who presented with progressive vision loss due to a recurrent right ONSM despite fractionated radiotherapy eight years prior and the subsequent interval regression of the tumor. Read More

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[Treatment and management of orbital tumors].

Ophthalmologe 2021 Oct 18;118(10):1004-1011. Epub 2021 Aug 18.

Klinik für Augenheilkunde, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

Background: There are various options for the conservative treatment of the most frequent orbital tumors. These can delay, complement or be superior to the surgical approach, which is often prone to complications.

Objective: This article gives a summary of the possible treatment options for the most common orbital tumors in childhood and adulthood. Read More

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October 2021

Ectopic intraconal orbital meningioma - A rare case report.

Surg Neurol Int 2021 28;12:305. Epub 2021 Jun 28.

Department of Neurosurgery, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

Background: Ectopic orbital meningiomas (OM) are a rare subset of OMs which are neither attached to the optic nerve sheath nor to the surrounding bone.

Case Description: We report the case of a 65-year-old female who presented with a 1 year history of proptosis followed by visual loss and restricted right eye movements since 3 months. Radiology of the orbits was suggestive of intraorbital, intraconal, and heterogeneous contrast enhancing right eye lesion which was completely excised through supraorbital orbitotomy approach. Read More

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68Ga-DOTATOC-PET/MRI-A Secure One-Stop Shop Imaging Tool for Robotic Radiosurgery Treatment Planning in Patients with Optic Nerve Sheath Meningioma.

Cancers (Basel) 2021 Jul 1;13(13). Epub 2021 Jul 1.

Department of Radiation Oncology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 13353 Berlin, Germany.

Optic nerve sheath meningiomas (ONSM) are rare but can lead to irreversible blindness. Hybrid imaging may enhance tumor delineation and diagnostic accuracy via receptor binding. However, relevant clinical data for ONSM are lacking. Read More

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Incipient Non-Arteritic Anterior Ischemic Optic Neuropathy in a Patient with Metastatic Small-Cell Lung Cancer.

Case Rep Ophthalmol 2021 May-Aug;12(2):513-518. Epub 2021 Jun 11.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.

A 70-year-old woman with metastatic small-cell lung cancer was referred for isolated left optic disc edema that was incidentally discovered. She had normal visual function, and dilated fundus examination revealed a small, cupless optic nerve in the right eye and moderate optic disc edema in the left eye. Magnetic resonance imaging (MRI) of the orbits with contrast was normal, and MRI brain and magnetic resonance venography were normal without signs of raised intracranial pressure. Read More

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Somatostatin receptor PET/CT scan as a helpful diagnostic tool for optic nerve sheath meningioma.

J Fr Ophtalmol 2021 Dec 3;44(10):e619-e621. Epub 2021 Jul 3.

Service d'ophtalmologie, centre hospitalier universitaire de l'hôpital Nord, Chemin des Bourrely, 13015 Marseille, France.

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December 2021

Bilateral calcification of the optic nerve sheath: A diagnostic dilemma.

Am J Ophthalmol Case Rep 2021 Jun 22;22:101106. Epub 2021 Apr 22.

Department of Ophthalmology, Oslo University Hospital, Norway.

Purpose: To present a case of symptomatic optic nerve sheath calcification and highlight clues and pitfalls for the final diagnosis: bilateral optic nerve sheath meningioma.

Observations: A 48-year-old man presented with painless vision loss in his left eye and findings consistent with left optic nerve atrophy. Magnetic resonance imaging (MRI) displayed thinning of the left optic nerve without contrast-enhancement or evidence of compressive lesions. Read More

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Effectiveness and Safety of Robotic Radiosurgery for Optic Nerve Sheath Meningiomas: A Single Institution Series.

Cancers (Basel) 2021 Apr 30;13(9). Epub 2021 Apr 30.

Charité Cyberknife Center, Augustenburger Platz 1, 13353 Berlin, Germany.

The role of robotic radiosurgery (RRS) in the treatment of optic nerve sheath meningiomas (ONSM) remains controversial and it is only performed in specialized institutions due to tight dose constraints. We evaluated the effectiveness and safety of RRS in the management of ONSM. Twenty-five patients with 27 ONSM lesions who underwent RRS using the Cyberknife (CK) system were retrospectively analyzed (median age, 47. Read More

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Surgical Treatment of Bilateral Optic Nerve Sheath Meningioma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 05;20(6):E418-E419

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Even though intracranial meningiomas commonly invade the optic canals, true optic nerve sheath meningiomas are extremely rare. They are insidious lesions that frequently grow in 4 stages, leading to progressive visual loss.1-4 Frequently, management includes observation for asymptomatic patients, and fractioned stereotactic radiotherapy with progressive visual loss. Read More

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Uncovering an Optic Nerve Sheath Meningioma Using 68Ga-DOTATATE PET/CT.

Clin Nucl Med 2021 Sep;46(9):e464-e465

From the Departments of Neurology.

Abstract: A 56-year-old woman was initially diagnosed with optic neuritis. However, several "red flags" were present: older age at presentation, no multiple sclerosis suspicious findings on MRI, and negative oligoclonal bands. 68Ga-DOTATATE PET/CT confirmed the differential diagnosis of an optic sheath meningioma. Read More

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September 2021

Approach to patient with unilateral optic disc edema and normal visual function.

J Neurol Sci 2021 05 24;424:117414. Epub 2021 Mar 24.

University of Toronto, Faculty of Medicine, Department of Ophthalmology and Vision Sciences, Toronto, Ontario, Canada; University of Toronto, Faculty of Medicine, Department of Medicine, Division of Neurology, Toronto, Ontario, Canada. Electronic address:

In patients with swollen optic nerve head and normal visual function, optic disc drusen (ODD) is the most common diagnosis. The best tests for detecting ODD are funds autofluorescence and enhanced-depth imaging ocular coherence tomography (EDIOCT). After ODD has been ruled out, asymmetric papilledema should be assumed to be the cause and MRI of the brain and orbits with contrast and venography should be performed in all patients. Read More

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Gaze-evoked amaurosis from idiopathic orbital inflammation.

Orbit 2021 Mar 29:1-4. Epub 2021 Mar 29.

Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, Canada.

Gaze-evoked amaurosis is a transient monocular vision loss elicited by eccentric gaze and has been reported in many orbital conditions but is most classically associated with intraconal tumors, such as cavernous hemangioma and optic nerve sheath meningioma. Here, the authors report a case of gaze-evoked amaurosis due to idiopathic orbital inflammation. The patient was a 35-year-old man who presented with vision loss only when abducting his left eye. Read More

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Primary and Secondary Optic Nerve Sheath Meningioma.

J Neurol Surg B Skull Base 2021 Feb 18;82(1):27-71. Epub 2021 Feb 18.

Divisions of Neuro-ophthalmology and Oculoplastics/Orbital Surgery, Department of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, New Jersey, United States.

 This study was aimed to review issues relating to the recognition, radiographic diagnosis, monitoring, and management of primary and secondary optic nerve sheath meningioma (ONSM).  This study is a review of peer-reviewed literature combined with illustrative case studies.  A literature search was conducted via the PubMed database using pertinent search terms. Read More

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February 2021

Case report Ga-DOTATATE of optic nerve sheath meningioma.

Am J Ophthalmol Case Rep 2021 Jun 5;22:101048. Epub 2021 Mar 5.

Department of Radiology, University of California, San Diego, United States.

We report a patient with an optic nerve sheath meningioma whose diagnosis and management were guided by using Gallium-68 DOTA-Tyr-octreotatate (Ga-DOTATATE). Positron Emission Tomography-Computed Tomography (PET-CT). Read More

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Prognostic Factors for Functional Outcome of Patients with Optic Nerve Sheath Meningiomas Treated with Stereotactic Radiotherapy-Evaluation of Own and Meta-Analysis of Published Data.

Cancers (Basel) 2021 Jan 29;13(3). Epub 2021 Jan 29.

Department of Radiosurgery and Stereotactic Radiotherapy, MediClin Robert Janker Clinic and MediClin MVZ Bonn, Villenstrasse 8, 53129 Bonn, Germany.

Objective: To evaluate prognostic factors for a favorable outcome (improvement of the visual acuity or visual fields) after fractionated stereotactic radiotherapy (fSRT) of optic nerve sheath meningioma (ONSM).

Methods: We performed a database search for ONSM treatments during the period from April 2008 to September 2019 in the prospective database for stereotactic radiosurgery/radiotherapy (SRS/SRT) of the Robert Janker Clinic Bonn (Department of Radiotherapy) and performed a literature review and meta-analysis of published data on ONSM between 2010 and 2019. Ophthalmic status before and after treatment was evaluated and the collective was dichotomized into two groups: functional improvement (FI; improvement of either visual acuity or visual fields) and non functional improvement (NFI; with stable or deteriorating visual acuity or visual fields). Read More

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January 2021

Unilateral Isolated Paucisymptomatic Optic Disc Edema.

J Neuroophthalmol 2021 12;41(4):e523-e534

Departments of Ophthalmology (EH, RAS, JHP, MD, NJN, VB), Pediatrics (JHP), Neurology (NJN, VB), and Neurological Surgery (NJN), Emory University School of Medicine, Atlanta, Georgia.

Background: Unilateral isolated optic disc edema (UIODE) represents a challenging clinical presentation that frequently precipitates an extensive diagnostic work-up. Patients without an apparent diagnosis despite appropriate investigations are often categorized as having "papillophlebitis," an entity that is poorly defined in the existing literature. Our aim was to describe the characteristics of a series of patients with paucisymptomatic UIODE, determine the optimal diagnostic approach to such cases, and clarify the clinical features of presumed papillophlebitis. Read More

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December 2021

An Atypical Paediatric Optic Nerve Sheath Meningioma.

Neuroophthalmology 2020 24;44(6):403-406. Epub 2020 Jun 24.

Department of Radiology, Uludag University, Bursa, Turkey.

A 16-year-old male presented with a three year history of right proptosis. All other ocular findings were normal. Imaging demonstrated a large, calcified, contrast-enhancing mass in the apical orbit. Read More

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The Coexistence of Olfactory Groove with Optic Nerve Sheath Meningioma Presenting with Anosmia: A Case Report.

Curr Med Imaging 2021 ;17(5):653-656

Department of Neurology, Ankara Yildirim Beyazit University, Ankara, Turkey.

Introduction: Meningiomas are the third most common intracranial tumors in adults after glial tumors and metastases. Olfactory groove meningiomas often grow without symptoms due to their slow growth rates and location in the frontal lobe. Optic nerve sheath meningiomas are benign neoplasms of the meninges surrounding the optic nerve. Read More

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October 2021

Optimal management in optic nerve sheath meningioma - A multicentre study and pooled data analysis.

J Clin Neurosci 2020 Oct 19;80:162-168. Epub 2020 Aug 19.

Save Sight Institute, Faculty of Health and Medicine, The University of Sydney, Australia; Dept of Ophthalmology, Macquarie University, Macquarie, NSW, Australia.

Optic nerve sheath meningiomas (ONSMs) are rare, benign neoplasms of the anterior visual pathway. The optimal modality of radiotherapy for treatment has not yet been established. This is the first study to show significant difference in visual outcomes between radiotherapy subtypes in the management of ONSM. Read More

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October 2020