26,053 results match your criteria Meningioma


Bevacizumab is an effective treatment for symptomatic cerebral necrosis after carbon ion therapy for recurrent intracranial malignant tumours: A case report.

Mol Clin Oncol 2022 Jul 19;17(1):114. Epub 2022 May 19.

The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.

Carbon ion therapy (CIT) is a form of particle therapy, which not only spares normal tissues but may also improve local control of recurrent intracranial tumours. Cerebral radiation necrosis (RN) is one of the most serious adverse reactions of recurrent brain tumours following reirradiation, which may lead to neurological decline or even death. Bevacizumab is an anti-vascular endothelial growth factor antibody, which has been used to treat symptomatic RN. Read More

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A Hybrid Deep Learning Model for Brain Tumour Classification.

Entropy (Basel) 2022 Jun 8;24(6). Epub 2022 Jun 8.

Department of Computer Science, College of Computer Science and Engineering, Taibah University, Medina 42353, Saudi Arabia.

A brain tumour is one of the major reasons for death in humans, and it is the tenth most common type of tumour that affects people of all ages. However, if detected early, it is one of the most treatable types of tumours. Brain tumours are classified using biopsy, which is not usually performed before definitive brain surgery. Read More

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The Role of [Ga]Ga-DOTA-SSTR PET Radiotracers in Brain Tumors: A Systematic Review of the Literature and Ongoing Clinical Trials.

Cancers (Basel) 2022 Jun 14;14(12). Epub 2022 Jun 14.

Department of Neurosurgery, Trauma Center, Gamma Knife Center, Cannizzaro Hospital, 95021 Catania, Italy.

Background: The development of [Ga]Ga-DOTA-SSTR PET tracers has garnered interest in neuro-oncology, to increase accuracy in diagnostic, radiation planning, and neurotheranostics protocols. We systematically reviewed the literature on the current uses of [Ga]Ga-DOTA-SSTR PET in brain tumors.

Methods: PubMed, Scopus, Web of Science, and Cochrane were searched in accordance with the PRISMA guidelines to include published studies and ongoing trials utilizing [Ga]Ga-DOTA-SSTR PET in patients with brain tumors. Read More

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Midline Skull Base Meningiomas: Transcranial and Endonasal Perspectives.

Cancers (Basel) 2022 Jun 10;14(12). Epub 2022 Jun 10.

Division of Neurosurgery, Department of Neurosciences and Reproductive and Odontostomatological Sciences, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.

Skull base meningiomas have always represented a challenge for neurosurgeons. Despite their histological nature, they may be associated with unfavorable outcomes due to their deep-seated location and the surrounding neurovascular structures. The state of the art of skull base meningiomas accounts for both transcranial, or high, and endonasal, or low, routes. Read More

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Current knowledge on spinal meningiomas: a systematic review protocol.

BMJ Open 2022 Jun 23;12(6):e061614. Epub 2022 Jun 23.

Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.

Introduction: Meningiomas are primary central nervous system tumours that arise from both cranial and spinal meninges. Spinal meningiomas occur less frequently than their cranial counterparts and are consequently given less attention in the literature. Therefore, systematic studies are needed to summarise the current knowledge on spinal meningiomas, providing a solid evidence base for treatment strategies. Read More

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The endonasal midline inferior intercavernous approach to the cavernous sinus: technical note, cadaveric step-by-step illustration, and case presentation.

Acta Neurochir (Wien) 2022 Jun 23. Epub 2022 Jun 23.

Department of Neurologic Surgery, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.

Purpose: Traditional endoscopic endonasal approaches to the cavernous sinus (CS) open the anterior CS wall just medial to the internal carotid artery (ICA), posing risk of vascular injury. This work describes a potentially safer midline sellar entry point for accessing the CS utilizing its connection with the inferior intercavernous sinus (IICS) when anatomically present.

Methods: The technique for the midline intercavernous dural access is described and depicted with cadaveric dissections and a clinical case. Read More

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Multiple primary pulmonary meningioma: A case report and literature review.

Thorac Cancer 2022 Jun 22. Epub 2022 Jun 22.

Department of Thoracic Surgery, Chengdu Third People's Hospital, the Affiliated Hospital of Southwest Jiaotong University, Chendu, China.

Lung cancer has become a leading cause of cancer-related deaths. With the conventional use of low-dose spiral computed tomography (CT) in physical examinations, an increasing number of small pulmonary nodules are screened. However, primary pulmonary meningiomas (PPMs) are rarely reported. Read More

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Diplopia outcomes following stereotactic radiosurgery for petroclival or cavernous sinus meningiomas: patient series.

J Neurosurg Case Lessons 2022 Jun 20;3(25):CASE225. Epub 2022 Jun 20.

Department of Neurosurgery, NYU Langone Medical Center, New York, New York.

Background: Skull base meningiomas (SBM) often present with diplopia due to compression of the abducens cranial nerve (CN VI). The authors evaluated outcomes in 13 patients diagnosed with SBMs who were experiencing diplopia to determine if Gamma Knife surgery (GKS) resulted in resolution of their symptoms.

Observations: Fourteen patients who were diagnosed with SBMs located in the cavernous sinus, clivus, or petroclival regions and presented with diplopia were treated by GKS. Read More

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somatic mosaicism in a patient with bilateral optic nerve sheath meningiomas: illustrative case.

J Neurosurg Case Lessons 2022 Jun 6;3(23):CASE2247. Epub 2022 Jun 6.

Departments of Ophthalmology.

Background: In the past decade, next-generation sequencing has spurred significant progress in the understanding of cytogenetic alterations that occur in meningiomas. Eighty percent of adult meningiomas harbor pathogenic somatic variants involving , , , , , or Somatic variants in associated with meningiomas usually localize to the gene's WD40 domains but are mutually exclusive to germline mutations, which cause a distinctive autosomal dominant syndrome.

Observations: This case involved a 15-year-old girl with bilateral optic nerve sheath meningiomas, diffuse meningiomatosis, and syndromic features, including craniosynostosis, brain anomalies, syndactyly, brachydactyly, epicanthus, and patent ductus arteriosus. Read More

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Commentary: Microsurgical Resection of a Petroclival Meningioma via a Suboccipital Approach: Technical Nuances and Anatomical Considerations: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2022 Jul 11;23(1):e56-e57. Epub 2022 May 11.

Division of Neurosurgery, Lehigh Valley Health Network, Allentown, Pennsylvania, USA.

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Dejerine Syndrome Variant Due to Medullary Perforating Artery Ischemia During Foramen Magnum Meningioma Resection: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2022 Jul 20;23(1):e52-e53. Epub 2022 Apr 20.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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Resection of Skull Base Meningioma With Extensive Extracranial Extension: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2022 Jul 20;23(1):e51. Epub 2022 Apr 20.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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Subtemporal Transcollateral Sulcus Approach for Temporal Horn Tumors: 2-Dimensional Operative Video and Description of the Technique.

Oper Neurosurg (Hagerstown) 2022 Jul 20;23(1):e10-e15. Epub 2022 Apr 20.

Department of Neurosurgery, The University of Arizona College of Medicine, Phoenix, Arizona, USA.

Introduction: Purely temporal intraventricular tumors are uncommon. Given their deep location, access to these brain tumors can be challenging in terms of preserving brain tissue. The subtemporal approach spares the lateral temporal cortex and is a less traumatic corridor to reach intraventricular temporal tumors. Read More

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MRI radiomics in the prediction of the volumetric response in meningiomas after gamma knife radiosurgery.

J Neurooncol 2022 Jun 17. Epub 2022 Jun 17.

Centro Gamma Knife Dominicano and Department of Radiology, CEDIMAT, Plaza de la Salud, Santo Domingo, Dominican Republic.

Purpose: This report presents the first investigation of the radiomics value in predicting the meningioma volumetric response to gamma knife radiosurgery (GKRS).

Methods: The retrospective study included 93 meningioma patients imaged by three Tesla MRI. Tumor morphology was quantified by calculating 337 shape, first- and second-order radiomic features from MRI obtained before GKRS. Read More

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The role of aquaporin 4 in brain tumors: implications for pathophysiology, diagnosis and therapy.

Mol Biol Rep 2022 Jun 17. Epub 2022 Jun 17.

Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, I.R. of Iran.

Primary brain tumors are a heterogeneous group of tumors that arise from cells intrinsic to the central nervous system (CNS). Aquaporin-4 (AQP4) has been implicated in the pathogenesis of brain tumors. Previous reports have documented a relationship between AQP4 and several molecular pathways associated with the etiology of brain tumors, such as apoptosis, invasion and cell migration. Read More

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Radiographic differentiation of secretory meningiomas and WHO grade 2 meningiomas: when atypical features are not always predictive of atypical tumors.

World Neurosurg 2022 Jun 17. Epub 2022 Jun 17.

Department of Neurological Surgery and Rosa Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH. Electronic address:

Objective: Secretory meningioma (SM) is a rare subtype of World Health Organization (WHO) grade 1 meningioma, associated with significant peritumoral brain edema (PTBE). Because of this, SM may be mistaken preoperatively to be a WHO grade 2 meningioma (G2M). In this study, we identified radiographic features to differentiate these two tumor types preoperatively to help inform surgical decision-making. Read More

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Magnetic Resonance Imaging of Unusual Neoplasms Related to Foramen of Luschka: A Review for Differential Diagnosis.

Indian J Radiol Imaging 2022 Mar 19;32(1):71-80. Epub 2022 Apr 19.

Department of Neurosurgery, Bahçeşehir University School of Medicine, Göztepe Medical Park Training and Education Hospital, Istanbul, Turkey.

There are many types of neoplasms in or around the foramen of Luschka (FL), and definitive diagnosis in some cases requires knowledge of imaging findings. The uncommon and challenging neoplasms with FL involvement considered in this study are exophytic brainstem glioma, primary glioblastoma of the cerebellopontine angle (CPA), primary anaplastic ependymoma of the CPA, choroid plexus papilloma of the FL, solitary FL choroid plexus metastasis, extraskeletal myxoid chondrosarcoma of the jugular foramen, paraganglioma of the jugular foramen, exostosis of the jugular foramen, psammomatous meningioma in the lateral cerebellar medullary cistern, epidermoid tumor of the fourth ventricle, and a hypoglossal schwannoma. These neoplasms may have overlapping clinical and imaging features, but some have relatively distinct imaging features. Read More

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The role of stereotactic radiosurgery in the management of petroclival meningioma: a systematic review.

J Neurooncol 2022 Jun 18. Epub 2022 Jun 18.

Department of Medicine, Universitas Pelita Harapan, Tangerang, Banten, Indonesia.

Purpose: Petroclival meningioma (PM) is a challenging neuro oncology case and stereotactic radiosurgery (SRS) is proposed as one treatment option. This systematic review aimed to examine the role of SRS in treating PM cases.

Methods:  We constructed a systematic review using the PRISMA guidelines using peer-reviewed English literature until 16 February 2022 from EuroPMC and PubMed. Read More

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Ceftazidime-avibactam and intrapleural amikacin therapy for extensively drug-resistant Pseudomonas aeruginosa thoracic empyema: A case report.

Medicine (Baltimore) 2022 Jun 17;101(24):e29467. Epub 2022 Jun 17.

Division of Infection Diseases, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.

Introduction: Thoracic empyema and concomitant bronchopleural fistula are serious complications of pneumonia. The treatment of empyema caused by extensively drug-resistant Pseudomonas aeruginosa (XDR-PA) has become increasingly challenging.

Patients Concerns And Important Clinical Findings: A 57-year-old woman with controlled schizophrenia developed hospital-associated bacterial pneumonia secondary to P. Read More

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Prevalence of autoimmunity and atopy in US adults with glioblastoma and meningioma.

Neuro Oncol 2022 Jun 17. Epub 2022 Jun 17.

Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Palo Alto, California, USA.

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Synthesizing Molecular and Immune Characteristics to Move Beyond WHO Grade in Meningiomas: A Focused Review.

Front Oncol 2022 31;12:892004. Epub 2022 May 31.

Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

No portion of this manuscript has previously been presented. Meningiomas, the most common primary intracranial tumors, are histologically categorized by the World Health Organization (WHO) grading system. While higher WHO grade is generally associated with poor clinical outcomes, a significant subset of grade I tumors recur or progress, indicating a need for more reliable models of meningioma behavior. Read More

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Potential Molecular Mechanisms of Recurrent and Progressive Meningiomas: A Review of the Latest Literature.

Front Oncol 2022 30;12:850463. Epub 2022 May 30.

Department of Pediatrics, Army Medical Center, Army Medical University, Chongqing, China.

Meningiomas, the most frequent primary intracranial tumors of the central nervous system in adults, originate from the meninges and meningeal spaces. Surgical resection and adjuvant radiation are considered the preferred treatment options. Although most meningiomas are benign and slow-growing, some patients suffer from tumor recurrence and disease progression, eventually resulting in poorer clinical outcomes, including malignant transformation and death. Read More

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Comparison of the Efficacy and Safety of Neuroendoscopic Endonasal Transsphenoidal Surgeries and Intracranial Endoscopic Pterional Approach in Resection of Tuberculum Sellae Meningiomas.

Evid Based Complement Alternat Med 2022 7;2022:4542815. Epub 2022 Jun 7.

Department of Neurosurgery, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian 363000, China.

Objective: To compare of the efficacy and safety of neuroendoscopic endonasal transsphenoidal surgeries and intracranial endoscopic pterional approach in resection of tuberculum sellae meningioma.

Methods: From January 2014 to June 2021, 60 patients with tuberculum sellae meningioma diagnosed and treated in our hospital were enrolled and randomly divided into study group and control group. The tuberculum sellae meningioma was removed by neuroendoscopic endonasal transsphenoidal surgeries in the study group, while the intracranial endoscopic pterional approach was used in the control group. Read More

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Validity of magnetic resonance imaging (MRI) in the primary spinal cord tumors in routine clinical setting.

Sci Rep 2022 Jun 16;12(1):10151. Epub 2022 Jun 16.

Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea.

MRI is the primary diagnostic modality for spinal cord tumors. However, its validity has never been vigorously scrutinized in daily routine clinical practice, where MRI tissue diagnosis is usually not a single one but multiple ones with several differential diagnoses. Here, we aimed to assess the validity of MRI in terms of predicting the pathology and location of the tumor in routine clinical settings. Read More

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Case of metachronous clear cell bladder metastasis on low risk localized renal cell carcinoma patient.

Int J Surg Case Rep 2022 May 6;96:107158. Epub 2022 May 6.

Department of Anatomical Pathology, Hasan Sadikin Academic Medical Center - Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.

Introduction: Renal cell carcinoma (RCC) is well known for its ability to metastasize into different organs. However, the management of metachronous RCC is still not yet standardized.

Case Presentation: A 62 years old man was presented with haematuria for the last 2 months. Read More

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Evaluation of Magnetic Resonance Imaging for Microsurgical Efficacy and Relapse of Rolandic Meningioma.

Comput Intell Neurosci 2022 6;2022:1026494. Epub 2022 Jun 6.

Department of Neurosurgery, Changde First People's Hospital, Changde 415000, Hunan, China.

In this study, magnetic resonance imaging (MRI) was used to evaluate the relapse features of patients with Rolandic meningioma after the microsurgery. 53 patients with Rolandic meningioma were selected as the research objects, and they were divided into the relapse group ( = 16) and nonrelapse group ( = 37) according to whether patients had a relapse during the follow-up period. Differences in quality of life, H-MRS index, vascular density, and cell proliferation between the two groups were assessed as well as imaging differences between the two groups were analyzed using MRI. Read More

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Pleiotropic variation confers risk of meningioma and estrogen-mediated cancers.

Neurooncol Adv 2022 Jan-Dec;4(1):vdac044. Epub 2022 Apr 15.

School of Public Health, Yale University, New Haven, Connecticut, USA.

Background: Risk of tumors of the breast, ovary, and meninges has been associated with hormonal factors and with one another. Genome-wide association studies (GWAS) identified a meningioma risk locus on 10p12 near previous GWAS hits for breast and ovarian cancers, raising the possibility of genetic pleiotropy.

Methods: We performed imputation-based fine-mapping in three case-control datasets of meningioma (927 cases, 790 controls), female breast cancer (28 108 cases, 22 209 controls), and ovarian cancer (25 509 cases, 40 941 controls). Read More

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Spatial heterogeneity in DNA methylation and chromosomal alterations in diffuse gliomas and meningiomas.

Mod Pathol 2022 Jun 14. Epub 2022 Jun 14.

Sahlgrenska Center for Cancer Research, Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Adult-type diffuse gliomas and meningiomas are the most common primary intracranial tumors of the central nervous system. DNA methylation profiling is a novel diagnostic technique increasingly used also in the clinic. Although molecular heterogeneity is well described in these tumors, DNA methylation heterogeneity is less studied. Read More

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