23,827 results match your criteria Meningioma


The effect of household income on outcomes following supratentorial meningioma resection.

Clin Neurol Neurosurg 2020 Jun 17;195:106031. Epub 2020 Jun 17.

Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States; McKenna EpiLog Fellowship in Population Health at the University of Pennsylvania, Philadelphia, PA, United States. Electronic address:

Objective: This study assesses the impact of Median Household Income (MHI) on short- and long-term morbidity and mortality following supratentorial meningioma resection.

Patients And Methods: 351 consecutive patients undergoing supratentorial meningioma tumor resection, at a single health system over a six-year period (June 09, 2013 to April 26, 2019) were analyzed retrospectively. Outcomes assessed included readmission, emergency department (ED) evaluation, and mortality within 90 days of surgery. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.106031DOI Listing

Predictors of Nonroutine Discharge Disposition Among Parasagittal/Parafalcine Meningioma Patients.

World Neurosurg 2020 Jul 8. Epub 2020 Jul 8.

Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231. Electronic address:

Objective: Discharge disposition is an important outcome for neurosurgeons to consider in the context of high-quality, value-based care. There has been limited research into how the unique anatomical considerations associated with parasagittal/parafalcine meningioma resection may influence discharge disposition. We investigated the effects of various predictors upon discharge disposition within a cohort of parasagittal/parafalcine meningioma patients. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.239DOI Listing

Role of adjuvant radiotherapy in atypical (WHO grade II) and anaplastic (WHO grade III) meningiomas: a systematic review.

Clin Transl Oncol 2020 Jul 10. Epub 2020 Jul 10.

Servicio de Oncología Radioterápica, Hospital Universitario de Burgos, Burgos, Spain.

The systematic adoption of the histopathologic criteria provided by the 2016 update of the WHO classification of brain tumors has markedly increased the relative proportion of atypical and anaplastic meningiomas. These tumors exhibit a much greater recurrence rate compared to benign meningiomas, which negatively impacts survival. In recent years, the publication of numerous retrospective case series, yet no randomized controlled trials, on the impact of radiation therapy in non-benign meningioma, has yielded conflicting evidence. Read More

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http://dx.doi.org/10.1007/s12094-020-02434-3DOI Listing

Teaching NeuroImages : Osteolytic intraosseous meningioma causing transcalvarial herniation.

Neurology 2020 Jul 10. Epub 2020 Jul 10.

Neurology Unit, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy;

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http://dx.doi.org/10.1212/WNL.0000000000010091DOI Listing

Risk factors analysis and a nomogram model establishment for late postoperative seizures in patients with meningioma.

J Clin Neurosci 2020 Jul 7. Epub 2020 Jul 7.

Department of Neurosurgery, Clinical Medical College of Yangzhou University, No. 98 Nantong West Road, Yangzhou 225001, China.

Background: Postoperative seizures (Sz) following surgical resection of intracranial meningiomas negatively impacts the quality of life of patients. However, there is still unclear with respect to the risk factors of and long-term freedom to Sz in patients with meningiomas. This study aimed to identify independent predictors and develop a nomogram model of late postoperative Sz to optimize postoperative surveillance. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.06.005DOI Listing

[Transcranial microsurgical decompression of the optic canal in surgical treatment of meningiomas of the sellar region].

Zh Vopr Neirokhir Im N N Burdenko 2020 ;84(3):61-73

Sechenov University, Moscow, Russia.

Rationale: When removing the meningiomas of the sellar region, there is always a risk of visual impairment for various reasons, in particular, as a result of traction damage to the optic nerve. Decompression of the optic canal increases nerve mobility during tumor manipulation. In cases of meningioma growing into the canal, its decompression often seems necessary. Read More

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http://dx.doi.org/10.17116/neiro20208403161DOI Listing
January 2020

[Radiation-induced meningiomas: analysis of 33 cases].

Zh Vopr Neirokhir Im N N Burdenko 2020 ;84(3):53-60

Burdenko Neurosurgical Center, Moscow, Russia.

Background: Development of meningiomas correlating with irradiation has been described in the last century. Different biological features of radiation-induced meningiomas depending on dose and type of irradiation have been observed in recent years.

Material And Methods: There were 8848 patients (women - 74. Read More

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http://dx.doi.org/10.17116/neiro20208403153DOI Listing
January 2020

[Intracranial meningiomas in children].

Zh Vopr Neirokhir Im N N Burdenko 2020 ;84(3):44-51

Federal Neurosurgical Center, Novosibirsk, Russia.

Meningiomas are rare in children and distinguished from the tumors in adults by clinical and biological aspects. Moreover, some histological forms and localizations are even casuistic in adults. There were 178 patients younger 18 years old with brain tumors. Read More

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http://dx.doi.org/10.17116/neiro20208403144DOI Listing
January 2020

Microsurgical Transcranial Approach of 112 Paraoptic Meningiomas: A Single-Center Case Series.

Oper Neurosurg (Hagerstown) 2020 Jul 10. Epub 2020 Jul 10.

Department of Neurosurgery, Rothschild Foundation Hospital, Paris, France.

Background: Predictors of visual outcomes after optic nerve decompression are controversial.

Objective: To identify the predictors of poor visual outcomes after surgery of meningiomas responsible of a compressive optic neuropathy.

Methods: We focused on paraoptic meningiomas (POMs), which gathered tuberculum sellae meningiomas (TSMs) and anterior clinoid meningiomas (ACMs) responsible for visual impairment or threatening visual function, that underwent surgery at our institution between January 2009 and December 2015 and analyzed the clinical and radiological findings of our patients. Read More

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http://dx.doi.org/10.1093/ons/opaa207DOI Listing

Neurosurgical intraoperative ultrasonography using contrast enhanced superb microvascular imaging -vessel density and appearance time of the contrast agent.

Br J Neurosurg 2020 Jul 10:1-10. Epub 2020 Jul 10.

Department of Orthopedics, Edogawa Hospital, Tokyo, Japan.

Ultrasonography (US) provides real-time information on structures within the skull during neurosurgical operations. Superb microvascular imaging (SMI) is the latest imaging technique for detecting very low-velocity flow with minimal motion artifacts, and we have reported on this technique for intraoperative US monitoring. We combined SMI with administration of contrast agent to obtain detailed information during neurosurgical operations. Read More

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http://dx.doi.org/10.1080/02688697.2020.1772958DOI Listing

Effect of tumor perfusion and receptor density on tumor control probability in Lu-DOTATATE therapy: An in silico analysis for standard and optimized treatment.

J Nucl Med 2020 Jul 9. Epub 2020 Jul 9.

Department of Nuclear Medicine, Ulm University, Germany.

The aim of this work was to determine a minimal tumor perfusion and receptor density for Lu-DOTATATE therapy using physiologically based pharmacokinetic (PBPK) modeling considering 1) a desired tumor control probability (TCP) of 99% and 2) a maximal tolerated biologically effective dose (BEDmax) for organs at risk (OARs) in the treatment of neuroendocrine tumors and meningioma. A recently developed PBPK model was employed. Nine virtual patients (i. Read More

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http://dx.doi.org/10.2967/jnumed.120.245068DOI Listing

The epidemiology of patients undergoing meningioma resection in Auckland, New Zealand, 2002 to 2011.

J Clin Neurosci 2020 Jul 6. Epub 2020 Jul 6.

Centre for Brain Research, Department of Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand.

The incidence of meningioma is known to vary by gender and ethnicity. This study aimed to describe the epidemiological characteristics of a 10-year cohort of patients undergoing meningioma resection at Auckland City Hospital, Auckland, New Zealand. Of particular interest was whether there was any difference in meningioma incidence and recurrence rates between New Zealand Maori and Pacific Island patients compared with other ethnic groups. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.06.011DOI Listing

Current status of PET imaging in neuro-oncology.

Neurooncol Adv 2019 May-Dec;1(1):vdz010. Epub 2019 May 28.

Department of Nuclear Medicine, University Hospital Aachen, Aachen, Germany.

Over the past decades, a variety of PET tracers have been used for the evaluation of patients with brain tumors. For clinical routine, the most important clinical indications for PET imaging in patients with brain tumors are the identification of neoplastic tissue including the delineation of tumor extent for the further diagnostic and therapeutic management (ie, biopsy, resection, or radiotherapy planning), the assessment of response to a certain anticancer therapy including its (predictive) effect on the patients' outcome and the differentiation of treatment-related changes (eg, pseudoprogression and radiation necrosis) from tumor progression at follow-up. To serve medical professionals of all disciplines involved in the diagnosis and care of patients with brain tumors, this review summarizes the value of PET imaging for the latter-mentioned 3 clinically relevant indications in patients with glioma, meningioma, and brain metastases. Read More

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http://dx.doi.org/10.1093/noajnl/vdz010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324052PMC

Histomolecular characterization of intracranial meningiomas developed in patients exposed to high-dose cyproterone acetate: an antiandrogen treatment.

Neurooncol Adv 2019 May-Dec;1(1):vdz003. Epub 2019 May 28.

University of Poitiers, Poitiers, France.

Background: Meningiomas are the most common primary intracranial tumors in adults. The relationship between meningiomas and exogenous sex hormones such as cyproterone acetate (CPA) is well documented, yet the underlying mechanisms remain unknown. Defining the histomolecular status of meningiomas developed on CPA would help us to better understand the oncogenesis of these tumors. Read More

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http://dx.doi.org/10.1093/noajnl/vdz003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212922PMC

Growing Dural Mass That Was Not a Meningioma.

JCO Oncol Pract 2020 Jul 9:OP2000348. Epub 2020 Jul 9.

Cleveland Clinic Florida, Weston, FL.

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http://dx.doi.org/10.1200/OP.20.00348DOI Listing

Radiosurgery vs. microsurgery for newly diagnosed, small petroclival meningiomas with trigeminal neuralgia.

Neurosurg Rev 2020 Jul 8. Epub 2020 Jul 8.

Department of Neurosurgery, Gangnam Severance Hospital, Yonsei University Health System, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, Republic of Korea.

Trigeminal neuralgia (TN) is an excruciating pain that can occur with petroclival meningiomas (PCMs). Gamma knife radiosurgery (GKRS) is an appealing option for small PCMs, but the role of microsurgery (MS) compared to GKRS is not well defined for small PCMs with regard to TN relief. From January 2009 to September 2019, 70 consecutive patients were treated by GKRS or MS for newly diagnosed, small (< 3. Read More

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http://dx.doi.org/10.1007/s10143-020-01346-8DOI Listing

The CREB-binding protein inhibitor ICG-001: a promising therapeutic strategy in sporadic meningioma with mutations.

Neurooncol Adv 2020 Jan-Dec;2(1):vdz055. Epub 2020 Feb 22.

Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Background: Meningiomas with Neurofibromin 2 gene mutations (-mutant meningiomas) account for ~40% of the sporadic meningiomas. However, there is still no effective drug treatment for the disease.

Methods: Expression profile of Merlin protein was explored through immunohistochemistry in a meningioma patient cohort ( = 346). Read More

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http://dx.doi.org/10.1093/noajnl/vdz055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212891PMC
February 2020

Constitutive activation of the EGFR-STAT1 axis increases proliferation of meningioma tumor cells.

Neurooncol Adv 2020 Jan-Dec;2(1):vdaa008. Epub 2020 Jan 21.

Faculty of Health: Medicine, Dentistry and Human Sciences, Institute of Translational and Stratified Medicine, University of Plymouth, Plymouth, UK.

Background: Meningiomas are the most frequent primary brain tumors of the central nervous system. The standard of treatment is surgery and radiotherapy, but effective pharmacological options are not available yet. The well-characterized genetic background stratifies these tumors in several subgroups, thus increasing diversification. Read More

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http://dx.doi.org/10.1093/noajnl/vdaa008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212880PMC
January 2020

Male hormone-interfering drugs and meningioma development.

Neurooncol Adv 2019 May-Dec;1(1):vdz046. Epub 2019 Nov 14.

Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark.

Background: Extremely strong associations between male hormone-interfering drugs and meningiomas have been reported in two previous studies, but these findings are limited by small size of the study populations and possibly by surveillance- and selection bias. Thus, such possible and indeed very interesting association must be investigated in a large, unselected cohort. Accordingly, the aim of this study was to determine whether patients exposed to male hormone-interfering drugs had a higher risk of meningioma development in a nationwide cohort study. Read More

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http://dx.doi.org/10.1093/noajnl/vdz046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212874PMC
November 2019

Identification of shared genomic aberrations between angiomatous and microcystic meningiomas.

Neurooncol Adv 2019 May-Dec;1(1):vdz028. Epub 2019 Sep 28.

Department of Neurosurgery, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.

Background: Angiomatous and microcytic meningiomas are classified as rare subtypes of grade I meningiomas by World Health Organization (WHO). They typically exhibit distinct histopathological features as indicated by their WHO titles; however, these angiomatous and microcystic features are often intermixed. Recently, angiomatous meningiomas were reported to show characteristic chromosomal polysomies unlike the other WHO grade I meningiomas. Read More

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http://dx.doi.org/10.1093/noajnl/vdz028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212863PMC
September 2019

Tumor-associated macrophage infiltration in meningioma.

Neurooncol Adv 2019 May-Dec;1(1):vdz018. Epub 2019 Sep 19.

Project neuroArm, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: Meningioma, a most common brain tumor, has a high rate of recurrence. Tumor-associated macrophages (TAMs) are the most abundant immune cell type in meningioma. TAMs display functional phenotypic diversity and may establish either an inflammatory and anti-tumoral or an immunosuppressive and pro-tumoral microenvironment. Read More

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http://dx.doi.org/10.1093/noajnl/vdz018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212927PMC
September 2019

Histological transformation in recurrent WHO grade I meningiomas.

Sci Rep 2020 Jul 8;10(1):11220. Epub 2020 Jul 8.

Department of Neurosurgery, Geneva University Hospitals, Rue Gabrielle Perret Gentil 4, 1205, Geneva, Switzerland.

Atypical or malignant transformation (AT/MT) has been described in WHO grade I meningiomas. Our aim was to identify predictive factors of AT/MT at recurrence. A total of N = 15 WHO grade increases were observed in N = 13 patients (0. Read More

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http://dx.doi.org/10.1038/s41598-020-68177-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343790PMC

Unresectable Foramen Magnum Meningioma Treated With CyberKnife Robotic Stereotactic Radiosurgery.

Cureus 2020 Jun 2;12(6):e8409. Epub 2020 Jun 2.

Radiation Oncology, The Ottawa Hospital, Ottawa, CAN.

Meningiomas are tumors that originate from the meningeal or dural cover of the brain and are the most common primary benign brain tumors. Currently, the accepted management of these tumors is attempted total surgical excision when technically possible and associated with an acceptable risk. However, radiation therapy has been shown to provide excellent local control when used either as an adjunct to surgery or as a primary treatment. Read More

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http://dx.doi.org/10.7759/cureus.8409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331916PMC

Stereotactic Radiosurgery and Stereotactic Radiotherapy for Malignant Skull Base Tumors.

Cureus 2020 Jun 1;12(6):e8401. Epub 2020 Jun 1.

CyberKnife Center, Aoyama General Hospital, Toyokawa, JPN.

The role of stereotactic radiosurgery/stereotactic radiotherapy (SRS/SRT) for malignant skull base tumors was summarized and discussed. The treatment of skull base tumors remains challenging. Their total resection is often difficult. Read More

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http://dx.doi.org/10.7759/cureus.8401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331921PMC

The Potential of MLN3651 in Combination with Selumetinib as a Treatment for Merlin-Deficient Meningioma.

Cancers (Basel) 2020 Jun 30;12(7). Epub 2020 Jun 30.

Peninsula Schools of Medicine and Dentistry, Institute of Translational and Stratified Medicine, Plymouth University, Plymouth PL68BU, UK.

Meningioma is the most common primary intracranial tumour, and surgical resection is the main therapeutic option. Merlin is a tumour suppressor protein that is frequently mutated in meningioma. The activity of the E3 ubiquitin ligase complex, CRL4-DCAF1, and the Raf/MEK/ERK scaffold protein Kinase suppressor of Ras 1 (KSR1) are upregulated in Merlin-deficient tumours, which drives tumour growth. Read More

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http://dx.doi.org/10.3390/cancers12071744DOI Listing

[Syncytial intramedullary meningioma associated with cervical syringomyelia].

Rev Neurol 2020 Jul;71(2):82-83

Complejo Hospitalario Universitario de Santiago de Compostela, 15706 Santiago de Compostela, España.

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http://dx.doi.org/10.33588/rn.7102.2020253DOI Listing

Determining the unmet needs of patients with intracranial meningioma-a qualitative assessment.

Neurooncol Pract 2020 Mar 29;7(2):228-238. Epub 2019 Oct 29.

Injury Prevention Research Office, St. Michael's Hospital, Division of Neurosurgery, Toronto, Ontario, Canada.

Background: Meningiomas are the most common primary benign brain neoplasms, but despite their commonality, the supportive needs of this patient population have been overlooked. The aim of this study is to identify unmet needs of meningioma patients, caregivers, and health care providers.

Methods: We adopted a patient-centered approach by using qualitative interviewing with patients diagnosed with a meningioma who have undergone treatment in the last 10 years since the date of their interview. Read More

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http://dx.doi.org/10.1093/nop/npz054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318855PMC

Neuroimaging findings in headache with normal neurologic examination: Systematic review and meta-analysis.

J Neurol Sci 2020 Jun 26;416:116997. Epub 2020 Jun 26.

Centre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.

Objective: To determine if pooled estimates of the prevalence of unexpected findings in patients with headache and normal neurologic examination support current expert opinion-based neuroimaging guidelines.

Methods: We searched PubMed and EMBASE for studies reporting neuroimaging findings in patients with headache and normal neurologic examination up to September 30, 2017. The overall and disease-specific prevalence of unexpected findings were pooled through random-effects meta-analysis. Read More

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http://dx.doi.org/10.1016/j.jns.2020.116997DOI Listing

Advances in Molecular Classification and Therapeutic Opportunities in Meningiomas.

Curr Oncol Rep 2020 Jul 3;22(8):84. Epub 2020 Jul 3.

Perlmutter Cancer Center, Brain and Spine Tumor Center, NYU Langone Health, 240 E. 38th Street, 19th floor, New York, NY, 10016, USA.

Purpose Of Review: Our understanding of the genetic and epigenetic alterations in meningioma and the underlying tumor biology of meningioma has significantly changed over the past decade and resulted in revision of prognostically relevant meningioma subclasses within and beyond the WHO classification of CNS tumors.

Recent Findings: The 2016 WHO classification of CNS tumors recognizes WHO grade I, II, and III based on histopathological features. Recent work has identified genetic alterations with prognostic implications, including mutations of the TERT promoter, loss of function of the DMD gene, and inactivation of the tumor suppressor BAP-1. Read More

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http://dx.doi.org/10.1007/s11912-020-00937-4DOI Listing

Unmet needs and recommendations to improve meningioma care through patient, partner, and health care provider input: a mixed-method study.

Neurooncol Pract 2020 Mar 2;7(2):239-248. Epub 2019 Nov 2.

Department of Neurosurgery, University Neurosurgical Center Holland (UNCH), Leiden University Medical Center and Haaglanden Medical Center, Leiden/The Hague, the Netherlands.

Background: It has been suggested that lack of ongoing registration of patient-centered outcomes has resulted in existing care trajectories that have not been optimized for sequelae experienced by meningioma patients. This study aimed to evaluate the structure of current meningioma care and identify issues and potential high-impact improvement initiatives.

Methods: Using the grounded theory approach, a thematic framework was constructed based on the Dutch Comprehensive Cancer Organisation survey about issues in meningioma care trajectories. Read More

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http://dx.doi.org/10.1093/nop/npz055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318860PMC

Mitotic Index and Progression Free Survival in Atypical Meningiomas.

World Neurosurg 2020 Jun 29. Epub 2020 Jun 29.

Neurologic Surgery Department, Mayo Clinic, Jacksonville, Florida, USA. Electronic address:

Extent of resection and tumor grade are considered as the most important predictor of progression free survival (PFS) in meningiomas. However, adjuvant therapy for atypical meningiomas remains controversial, with variable PFS rates of up to 40%. Current Mitotic Index (MI) range for atypical meningiomas is broad, comprising all tumors with >4 and <20 mitotic count per 10 HPF; leading to substantial within-grade variation of recurrence risk, especially in borderline histologic cases, creating discordance between the clinical course and the application of the classification criteria. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.189DOI Listing

The Ki-67 Proliferation Index as a Marker of Time to Recurrence in Intracranial Meningioma.

Neurosurgery 2020 Jul 2. Epub 2020 Jul 2.

Department of Neurosurgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Background: There are examples of incongruence between the WHO grade and clinical course in meningioma patients. This incongruence between WHO grade and recurrence has led to search for other prognostic histological markers.

Objective: To study the correlation between the Ki-67 proliferative index (PI), risk of recurrence, and recurrence rates in meningioma patients. Read More

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http://dx.doi.org/10.1093/neuros/nyaa226DOI Listing

[Expression of mucin-4 in meningiomas and its diagnostic significance].

Zhonghua Bing Li Xue Za Zhi 2020 Jul;49(7):727-732

Department of Pathology, the First Affiliated Hospital of University of Science and Technology of China; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230036, China.

To investigate the expression of mucin-4 (MUC4) in meningiomas. Totally 258 cases of meningiomas and 165 cases of other brain tumors were collected from the First Affiliated Hospital of China University of Science and Technology (Anhui Provincial Hospital) from 2011 to 2017. MUC4, EMA, PR, SSTR-2 protein expression was detected by immunohistochemistry, and their expression in meningiomas and other tumor tissue was compared. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20191121-00749DOI Listing

High Diagnostic Accuracy of Visible 5-ALA Fluorescence in Meningioma Surgery According to Histopathological Analysis of Tumor Bulk and Peritumoral Tissue.

Lasers Surg Med 2020 Jul 1. Epub 2020 Jul 1.

Department of Neurosurgery, Medical University Vienna, Waehringer Gürtel 18-20, Vienna, 1090, Austria.

Background And Objectives: Complete neurosurgical resection of intracranial meningiomas is essential to avoid residual tumor tissue and thus minimize the risk of tumor recurrence. However, local recurrence of meningiomas is not uncommon mainly due to insufficient intraoperative detection of residual tumor tissue within the tumor bulk or peritumoral tissue such as bone and satellite lesions. Although 5-aminolevulinic acid (5-ALA) induced fluorescence was found to visualize the majority of meningiomas, no comprehensive histopathological assessment of fluorescing samples from the tumor bulk and peritumoral tissue is available. Read More

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http://dx.doi.org/10.1002/lsm.23294DOI Listing

Hypofractionated stereotactic radiosurgery for large-sized skull base meningiomas.

J Neurooncol 2020 Jul 1. Epub 2020 Jul 1.

Radiosurgery Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: Although stereotactic radiosurgery (SRS) has been proven to be effective and safe for treating intracranial meningiomas, concerns have been raised about the use of SRS for large-sized tumors involving the skull base that frequently encroach onto adjacent critical neural structures. The purpose of this study was to investigate the role of hypofractionated SRS as a therapeutic option for large-sized skull base meningiomas.

Methods: Thirty-one consecutive patients (median age: 55 years, 9 men and 22 women) who had been treated with hypofractionated SRS using CyberKnife for large-sized skull base meningiomas (> 10 cm in volume, median of 18. Read More

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http://dx.doi.org/10.1007/s11060-020-03575-9DOI Listing

Compressive optic neuropathy. Not everything that progresses is glaucoma.

Arch Soc Esp Oftalmol 2020 Jun 27. Epub 2020 Jun 27.

Institut Català de Retina, Departamento de Glaucoma, Barcelona, España; Universitat Internacional de Catalunya, Barcelona, España.

Three clinical cases are presented of compressive optic neuropathy secondary to meningiomas of different locations, initially diagnosed with normal tension glaucoma (NTG). All patients were middle-aged women, with optic disc excavation, as well as asymmetric, rapidly progressive defects in the visual field (VF), and deterioration of the visual acuity (VA), despite presenting with intraocular pressure (IOP) correctly controlled with topical hypotensive therapy. Due to the atypical progression of the glaucoma disease, and suspecting a compressive lesion of the optic nerve, neuroimaging tests were performed, with which the correct diagnosis was reached. Read More

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http://dx.doi.org/10.1016/j.oftal.2020.05.017DOI Listing

Stratifying Brain Tumour Histological Sub-Types: The Application of ATR-FTIR Serum Spectroscopy in Secondary Care.

Cancers (Basel) 2020 Jun 27;12(7). Epub 2020 Jun 27.

WestCHEM, Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, 99 George St, Glasgow G1 1RD, UK.

Patients living with brain tumours have the highest average years of life lost of any cancer, ultimately reducing average life expectancy by 20 years. Diagnosis depends on brain imaging and most often confirmatory tissue biopsy for histology. The majority of patients experience non-specific symptoms, such as headache, and may be reviewed in primary care on multiple occasions before diagnosis is made. Read More

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http://dx.doi.org/10.3390/cancers12071710DOI Listing

Prostate-Specific Membrane Antigen-Avid Meningioma Detected in 68Ga-Prostate-Specific Membrane Antigen PET/CT.

Clin Nucl Med 2020 Jun 25. Epub 2020 Jun 25.

From the Department of Nuclear Medicine and PET/CT Mahajan Imaging Centre, Sir Ganga Ram Hospital, New Delhi, India.

A 64-year-old man with recently diagnosed prostate adenocarcinoma with a total prostate-specific antigen level of 3.32 ng/mL and Gleason score 4 (3 + 4) was referred for Ga-prostate-specific membrane antigen PET/CT scan for pretreatment staging. Prostate-specific membrane antigen-avid lesion was noted in the right lobe of the prostate gland, corresponding to the known primary lesion. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003172DOI Listing

TRANS-FRONTAL SINUS APPROACH FOR OLFACTORY GROOVE MENINGIOMAS: A 19 YEAR EXPERIENCE.

Clin Neurol Neurosurg 2020 Jun 24;196:106041. Epub 2020 Jun 24.

Division of Neurosurgery, AO Ospedale Civile di Legnano, Legnano, Italy.

Introduction: Olfactory groove meningiomas (OGMs) account for 8-13 % of all intracranial meningiomas. The gold standard of treatment is generally surgery, however various approaches have been used and the literature is still uncertain about the superiority of one treatment over the others. The most debated techniques are traditional microscopic open approaches versus the endoscopic endonasal ones. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.106041DOI Listing

Dural-based atypical teratoid/rhabdoid tumor in an adult: DNA methylation profiling as a tool for the diagnosis.

CNS Oncol 2020 Jun 30;9(2):CNS54. Epub 2020 Jun 30.

Department of Radiological, Oncological & Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy.

Atypical teratoid/rhabdoid tumor (ATRT) is a malignant CNS embryonal tumor that mostly occurs in childhood, adult cases are rare. We report a case of a 23-year-old male with an extra-axial dura-based lesion in the left frontal area, previously diagnosed as gliosarcoma. After 6 years, the patient had a recurrence and the previous slides were reviewed. Read More

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http://dx.doi.org/10.2217/cns-2020-0006DOI Listing

Surgery as a safe and effective treatment option for spheno-orbital meningioma: a systematic review and meta-analysis of surgical techniques and outcomes.

Acta Ophthalmol 2020 Jun 29. Epub 2020 Jun 29.

Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands.

Purpose: The effectiveness and safety of surgery for spheno-orbital meningiomas remains subject of debate, as studies often describe different surgical approaches and reconstruction techniques with very heterogeneous outcomes. We aimed to systematically summarize and analyse the literature on spheno-orbital meningiomas regarding presenting symptoms, surgical techniques, outcomes and complications.

Methods: Studies were retrieved from eight databases. Read More

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http://dx.doi.org/10.1111/aos.14517DOI Listing

Intraoperative frozen cytology of intraosseous cystic meningioma in the sphenoid bone.

J Pathol Transl Med 2020 Jul 1. Epub 2020 Jul 1.

Department of Neurosurgery, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.

Meningiomas in bone are rarely subjected to fine-needle aspiration diagnosis, and those arising in the skull bone with a cystic presentation are rare. A 24-year-old woman presented with subdural hemorrhage, and subsequent radiology depicted an osteolytic mass-like lesion in the sphenoid bone. Intraoperatively, a solid and cystic hemorrhagic lesion mimicking an aneurysmal bone cyst was observed in the sphenoid bone with dural tearing. Read More

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http://dx.doi.org/10.4132/jptm.2020.05.21DOI Listing

Scalp invasion by atypical or anaplastic meningioma is a risk factor for development of systemic metastasis.

World Neurosurg 2020 Jun 26. Epub 2020 Jun 26.

Introduction: Atypical and anaplastic meningiomas (AAM) are rare and comprise approximately 5% of all meningiomas. Extracranial metastases in meningioma patients occur in 0.1% of all cases but these lesions are difficult to treat and may be a poor prognostic factor. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.148DOI Listing

Integrated Transcriptomic Analysis Reveals the Molecular Mechanism of Meningiomas by Weighted Gene Coexpression Network Analysis.

Biomed Res Int 2020 10;2020:4927547. Epub 2020 Jun 10.

Department of Neurosurgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201999, China.

Meningiomas are the most common primary intracranial tumor in adults. However, to date, systemic coexpression analyses for meningiomas fail to explain its pathogenesis. The aim of the present study was to construct coexpression modules and identify potential biomarkers associated with meningioma progression. Read More

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http://dx.doi.org/10.1155/2020/4927547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303753PMC

Meningioma infiltrating into porous polymethylmethacrylate cranioplasty-report of a unique case.

J Surg Case Rep 2020 Jun 19;2020(6):rjaa149. Epub 2020 Jun 19.

Department of Neurosurgery, University Medical Center Regensburg, Regensburg, Germany.

Implantation of a cranioplasty after osteoclastic craniotomy or craniectomy is one of the most common neurosurgical procedures, and polymethylmethacrylate (PMMA) is one of the most frequently applied materials for cranioplasty. This report describes the unique case of a patient with recurrent transitional meningioma WHO I that infiltrated the PMMA cranioplasty 7 years after primary surgery. We propose to restrict the use of porous PMMA as cranioplasty after the removal of convexity meningioma. Read More

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http://dx.doi.org/10.1093/jscr/rjaa149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303020PMC

Ten-year follow-up after Gamma Knife radiosurgery of meningioma and review of the literature.

Acta Neurochir (Wien) 2020 Jun 26. Epub 2020 Jun 26.

Department of Neurosurgery, Karolinska Hospital, S-17176, Stockholm, Sweden.

Objectives: With regard to the generally slow growth of meningioma, it is essential to analyse clinical treatment results in a long-term perspective. The purpose of the present analysis is to provide clinical data after Gamma Knife radiosurgery of meningioma in a 10-year perspective together with a review of the current literature.

Methods: The current study is a retrospective analysis of 86 consecutive Swedish patients with meningiomas treated using Gamma Knife radiosurgery at the Karolinska Hospital Stockholm between March 1991 and May 2001. Read More

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http://dx.doi.org/10.1007/s00701-020-04350-5DOI Listing

Transcallosal-lateral ventricle-choroid fissure approach for excising large pineal region tumors extending into the third ventricle: experience in 15 pediatric cases.

Childs Nerv Syst 2020 Jun 25. Epub 2020 Jun 25.

Department of Neurosurgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, Guangxi, People's Republic of China.

Pineal region is deep located and tightly connected with surrounding important nerves, blood vessels, and other critical structure. Tumors in the regions are more commonly observed in children with complex pathology, difficult surgery, and poor prognosis. However, excision surgery on large tumor in the pineal region and extending into the third ventricle is characterized by high difficulty and uneasy treatment. Read More

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http://dx.doi.org/10.1007/s00381-020-04742-zDOI Listing

Proteomics pinpoints alterations in grade I meningiomas of male versus female patients.

Sci Rep 2020 Jun 25;10(1):10335. Epub 2020 Jun 25.

Laboratory for Structural and Computational Proteomics, Carlos Chagas Institute, Fiocruz, Paraná, Curitiba, Brazil.

Meningiomas are among the most common primary tumors of the central nervous system (CNS) and originate from the arachnoid or meningothelial cells of the meninges. Surgery is the first option of treatment, but depending on the location and invasion patterns, complete removal of the tumor is not always feasible. Reports indicate many differences in meningiomas from male versus female patients; for example, incidence is higher in females, whereas males usually develop the malignant and more aggressive type. Read More

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http://dx.doi.org/10.1038/s41598-020-67113-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316823PMC

Parasagittal meningiomas.

Authors:
Tiit Mathiesen

Handb Clin Neurol 2020 ;170:93-100

Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden. Electronic address:

Parasagittal meningiomas are defined as meningiomas that grow into at least one wall of the superior sagittal sinus. Long- and short-term morbidity is, in addition to cortical function, related to management of venous structures and flow. Clinical management needs to address the extent of removal in the sinus wall and to address relations to the adjacent cortex, which is highly eloquent in the Rolandic and calcarine areas. Read More

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http://dx.doi.org/10.1016/B978-0-12-822198-3.00031-8DOI Listing
January 2020