24,919 results match your criteria Meningioma


Sarcomatous Meningioma: Diagnostic Pitfalls and the Utility of Molecular Testing.

J Neuropathol Exp Neurol 2021 Jun 12. Epub 2021 Jun 12.

Department of Pathology (C-HGL, PD, DAS, AP); Clinical Cancer Genomics Laboratory (PD), University of California, San Francisco, California, UUSA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA (CG); Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany (GR); Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA (SD); Department of Pathology, Sutter Medical Center, Sacramento (DC); Department of Neurological Surgery, University of California, San Francisco (AP), California, USA.

Anaplastic meningiomas can have a sarcomatous appearance on histology but true sarcomatous (metaplastic) differentiation is rare. These tumors follow an aggressive clinical course with recurrence and poor clinical outcomes. Due to significant overlap in morphology and immunohistochemical profiles, distinguishing between sarcomatous transformation of a meningioma and a true sarcoma can be challenging. Read More

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Concurrence of craniopharyngioma and meningioma: a case report and systematic review of the literature.

Br J Neurosurg 2021 Jun 14:1-6. Epub 2021 Jun 14.

Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

Craniopharyngioma (CPG) is a benign epithelial tumor that originates from Rathke's pouch. Meningiomas (MNG) are neoplasms of meningothelial cell. The patient is a 42-year-old female who presented with left-sided temporal headaches and visual acuity impairment. Read More

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Clinical Factors and Outcomes of Atypical Meningioma: A Population-Based Study.

Front Oncol 2021 26;11:676683. Epub 2021 May 26.

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.

Objective: Atypical meningioma is a non-benign tumor, and its prognostic factors and treatment strategies are unclear.

Methods: Patients with atypical meningioma, between 2004 and 2016, were collected from the Surveillance, Epidemiology, and End Results database. Then, we randomly divided patients into a training set and a validation set at a ratio of 8:2. Read More

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Preoperative Prediction of Meningioma Consistency Machine Learning-Based Radiomics.

Front Oncol 2021 26;11:657288. Epub 2021 May 26.

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Objectives: The aim of this study was to establish and validate a radiomics nomogram for predicting meningiomas consistency, which could facilitate individualized operation schemes-making.

Methods: A total of 172 patients was enrolled in the study (train cohort: 120 cases, test cohort: 52 cases). Tumor consistency was classified as soft or firm according to Zada's consistency grading system. Read More

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Biological Treatments of Neurofibromatosis Type 2 and Other Skull Base Disorders.

Otolaryngol Clin North Am 2021 Jun 10. Epub 2021 Jun 10.

Gilbert Family Neurofibromatosis Institute, Children's National Hospital, 111 Michigan Avenue Northwest, Washington, DC 20010, USA; Department of Pediatric Hematology-Oncology; Center for Genetics Research, Children's National Hospital, 111 Michigan Avenue Northwest, Washington, DC 20010, USA. Electronic address:

Studies of genomic alterations that occur in skull base tumors have provided information regarding biological aberrations that are necessary for the growth and maintenance of these tumors. This has led to the development and initiation of clinical trials incorporating biological treatments for many skull base tumors. The exciting developments of molecularly targeted therapy for the treatment of skull base tumors may provide noninvasive therapeutic options for patients that can be used either alone or in combination with surgery and/or radiation therapy. Read More

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Case report: An epidural cavernous hemangioma mimicking a dumbbell-shaped neuroma.

Int J Surg Case Rep 2021 Jun 9;84:106069. Epub 2021 Jun 9.

Army Hospital of Rome "Celio", Clinical Pathology Department, Via S. Stefano Rotondo n. 4, 00184 Roma, Italy.

Introduction And Importance: Spinal epidural cavernous hemangiomas are a rare occurrence. This particular case is made even more distinctive by the fact that the lesion mimicked a dumbbell-shaped neuroma. Moreover, it had a very unique localization (wholly epidural, at cervical-thoracic -C7-D1- level). Read More

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Piezosurgery for safe and efficient petrous bone cutting in cerebellopontine angle and petroclival meningioma surgery.

J Clin Neurosci 2021 Jul 21;89:319-328. Epub 2021 May 21.

Department of Neurosurgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Intradural petrous bone drilling has become a widespread practice, providing extended exposure in the removal of cerebellopontine angle (CPA) or petroclival tumors. Adjacent neurovascular structures are at risk, however, when drilling is performed in this deep and narrow area. Hence, this study evaluates the use of Piezosurgery (PS) as a non-rotating tool for selective bone cutting in CPA surgery. Read More

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Characteristics of cases with and without calcification in spinal meningiomas.

J Clin Neurosci 2021 Jul 29;89:20-25. Epub 2021 Apr 29.

Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65, Tsurumai-cho, Showa-ku, Nagoya 466-8560, Japan.

Purpose: To quantify calcification in spinal meningiomas using Hounsfield unit (HU) values on CT, and to analyze the characteristics of cases with and without calcification and with different histologic subtypes.

Methods: The subjects were 53 patients who underwent surgical resection of spinal meningioma between January 1999 and December 2019. Clinical and surgical data were collected, and all patients were examined neurologically preoperatively and at final follow-up using the modified McCormick scale and the American Spinal Injury Association scale. Read More

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Does general comorbidity impact the postoperative outcomes after surgery for large and giant petroclival meningiomas?

Neurosurg Rev 2021 Jun 12. Epub 2021 Jun 12.

Service de Neurochirurgie, CHU Nord, APHM-AMU, Marseille, France.

We assessed the role of the general condition of the patient in addition to usual anatomical reasoning to improve the prediction of personalized surgical risk for patients harboring a large and giant petroclival meningiomas. Single-center, retrospective observational study including adult patients surgically treated for a large and giant petroclival meningioma between January 2002 and October 2019 in a French tertiary neurosurgical skull-base center by one Neurosurgeon. Inclusion criteria were as follows: (1) histopathologically proven meningioma; (2) larger than 3 cm in diameter; (3) located within the upper two-thirds of the clivus, the inferior petrosal sinus, or the petrous apex around the trigeminal incisura, medial to the trigeminal nerve. Read More

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Predictors of progression in radiation-induced versus nonradiation-induced pediatric meningiomas: a large single-institution surgical experience.

J Neurosurg Pediatr 2021 Jun 11:1-7. Epub 2021 Jun 11.

1Department of Neurosurgery, Boston Children's Hospital.

Objective: The goal in this study was to outline unique differences between radiation-induced and nonradiation-induced pediatric meningiomas and to identify independent risk factors of tumor recurrence/progression.

Methods: This is a retrospective cohort study of all pediatric meningiomas diagnosed and surgically treated at the authors' institution between 1993 and 2017. Multivariable Cox regression was applied to identify independent risk factors for tumor recurrence/progression. Read More

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Meningioma preceding CASPR2 antibody limbic encephalitis with a stroke mimic: A case report.

Medicine (Baltimore) 2021 Jun;100(23):e26241

Department of Neurology, Weifang People's Hospital (The First Affiliated Hospital of Weifang Medical University), Weifang, Shandong, China.

Rationale: Todd paralysis (a stroke-like presentation in some patients with epilepsy) caused by limbic encephalitis (LE) is not easily distinguished from acute ischemic stroke by clinicians in the emergency room.

Patient Concerns: We report a contactin-associated protein-like 2-antibody (CASPR2-Ab)-positive patient who presented with atypical LE.

Diagnoses: CASPR2-Ab-positive LE was the presumed diagnosis. Read More

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Giant skull base mass need not be a tumor - a rare presentation of IgG4-related disease.

Br J Neurosurg 2021 Jun 11:1-4. Epub 2021 Jun 11.

Department of Neurosurgery, PGIMER, Chandigarh, India.

Background: Giant intracranial 'IgG4-related' lesions are uncommon. They may present as pachymeningitis or localized mass. Here we report, probably, the largest IgG4 skull base mass ever to be reported. Read More

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Endoscopic Endonasal and Supraorbital Removal of Tuberculum Sellae Meningiomas: Anatomic Guides and Operative Nuances for Keyhole Approach Selection.

Oper Neurosurg (Hagerstown) 2021 Jun 10. Epub 2021 Jun 10.

Pacific Neuroscience Institute, Santa Monica, California, USA.

Background: With growing worldwide endoscopy experience, endonasal and supraorbital removal of tuberculum sellae meningiomas (TSM) has increased.

Objective: To describe anatomic factors for guiding approach selection and outcomes.

Methods: Retrospective analysis of patients undergoing endonasal or supraorbital TSM resection: approach criteria, clinical outcomes, acute magnetic resonance imaging (MRI) fluid-attenuated inversion-recovery (FLAIR)/T2 changes. Read More

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The Efficacy and Safety of Carbon Ion Radiotherapy for Meningiomas: A Systematic Review and Meta-Analysis.

Front Oncol 2021 25;11:620534. Epub 2021 May 25.

Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.

Objective: The purpose of this systematic review and meta-analysis is to evaluate the efficacy and safety of carbon ion radiotherapy (CI-RT) in improving meningioma by comparing photon and protons radiotherapy.

Methods: A comprehensive search for relevant studies published until March 17, 2021, was conducted in PubMed, the Cochrane Library, Chinese Biomedical Literature Database and EMBASE. Statistical analyses were performed with R 4. Read More

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Atypical Meningioma of the Sinonasal Tract.

Cureus 2021 May 8;13(5):e14908. Epub 2021 May 8.

Head and Neck-Plastics and Reconstructive Surgery, Erie County Medical Center, Buffalo, USA.

This case report describes a patient with intellectual disability who presented with a neglected midline nasal mass eroding the anterior skull base, which was found to be a Grade II meningioma likely of the olfactory bulb. Points of interest include differential diagnosis of this atypical mass of the sinonasal tract, as well as decision-making in balancing appropriate management and quality of life in a patient with developmental delay who could not make decisions for herself. Literature review regarding the role of adjuvant radiation based on final diagnosis and extent of disease suggests that radiation can improve locoregional control and overall survival with atypical meningioma. Read More

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Association between tumor size and peritumoral brain edema in patients with convexity and parasagittal meningiomas.

PLoS One 2021 10;16(6):e0252945. Epub 2021 Jun 10.

Department of Neurosurgery, Hanyang University Guri Hospital, Guri, Gyonggi-do, Korea.

Background And Purpose: Peritumoral brain edema (PTBE) is a common complication in meningioma and disruption of the tumor-brain barrier in meningioma is crucial for PTBE formation. To evaluate the association between meningioma size and PTBE, we measured meningioma volumes using the 3D slicer in patients with convexity and parasagittal meningiomas.

Methods: Receiver operating characteristic curve analysis was used to determine the optimal cut-off meningioma volume values for predicting PTBE occurrence. Read More

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An International Multicenter Matched Cohort Analysis of Incidental Meningioma Progression During Active Surveillance or After Stereotactic Radiosurgery: The IMPASSE Study.

Neuro Oncol 2021 Jun 9. Epub 2021 Jun 9.

Department of Neurosurgery, University of Liverpool & The Walton Centre NHS Trust, Lower Lane, Liverpool, UK.

Background: The optimal management of patients with an incidental meningiomas remains unclear. The aim of this study was to characterize the radiologic and neurological outcomes of expectant and SRS management of asymptomatic meningioma patients.

Methods: Using data from 14 centers across 10 countries, the study compares SRS outcomes to active surveillance of asymptomatic meningiomas. Read More

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Tailored Anterior Clinoidectomy: Beyond the Intradural and Extradural Concepts.

Cureus 2021 May 6;13(5):e14874. Epub 2021 May 6.

Neurosurgery, Hospital Universitario Antonio Pedro, Niterói, BRA.

Anterior clinoidectomy (AC) is a key microsurgical step for the safe and successful management of parasellar pathologies that involve the anterior clinoid process (ACP) and the optic canal. Traditionally, extra and intradural ACs are performed separately according to the surgeon's experience or preference. The objective is to present and discuss the tailored AC concept through illustrative cases. Read More

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The Dural Dark-Side Approach for falcine and tentorial meningioma: a surgical series of five patients.

Neurochirurgie 2021 Jun 4. Epub 2021 Jun 4.

Department of Neurosurgery, Foch Hospital, 40 Rue Worth, 92150 Suresnes, France.

Introduction: Falcine or tentorial meningioma can be complex to resect. When large meningiomas are located in eloquent areas, a direct ipsilateral surgical approach may cause brain injury and postoperative neurological deficits. In this series, 5 patients were surgically treated using a contralateral transfalcine or transtentorial approach to minimize brain retraction. Read More

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Heterotopic ossification in psammomatous spinal meningioma: a diagnostic controversy.

Int J Clin Exp Pathol 2021 15;14(5):627-632. Epub 2021 May 15.

Division of Neurosurgery, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia Jalan Yaacob Latiff, Bandar Tun Razak, Cheras 56000, Kuala Lumpur, Malaysia.

Heterotopic ossification (HO), a synonym for osseous metaplasia, is a pathological phenomenon, characterized by abnormal bone formation outside the skeletal system observed commonly in various neoplastic and non-neoplastic diseases. HO occurring in meningioma is exceptionally rare. We reportherein an unusual case of spinal meningioma containing numerous calcified psammoma bodies and extensive HO in a 75-year-old woman, who presented with progressive worsening bilateral lower limb weakness and numbness. Read More

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Left Transradial Neurointerventions using the 6Fr Simmons Guiding Sheath: Initial Experiences with the Interchange Technique.

World Neurosurg 2021 Jun 1. Epub 2021 Jun 1.

Department of Neurosurgery, St. Marianna University School of Medicine, Kanagawa, Japan.

Background: The transradial approach using a Simmons-shaped catheter has been increasingly used for diagnostic cerebral angiography and neurointervention. In the transradial approach for neurointervention, the right radial artery is mainly used. However, in interventional cardiology, there are apparent clinical benefits with the left transradial approach for right-handed patients. Read More

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Primary intraspinal benign tumors treated surgically: an analysis from China.

Br J Neurosurg 2021 Jun 4:1-4. Epub 2021 Jun 4.

Department of Orthopaedics, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.

Purpose: The purpose of this study was to review the clinical features in a cohort of Chinese patients with primary intraspinal benign tumors.

Methods: This retrospective study included a consecutive series of patients with intraspinal benign lesions who received surgery between January 2014 and October 2018 at our hospital. We collected each patient's clinical data, including age, gender, presenting symptoms, the spinal level (cervical, thoracic, lumbar, or sacral), and location (intramedullary or extramedullary) of the tumor. Read More

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Ocular neuromyotonia caused by a recurrent sphenoidal ridge meningioma.

Surg Neurol Int 2021 10;12:219. Epub 2021 May 10.

Department of Neurosurgery, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan.

Background: Ocular neuromyotonia (ONM) is a rare ocular motility disorder characterized by involuntary paroxysmal extraocular muscle contraction and is caused by radiation therapy, vascular compression, and inflammatory disease. This study includes a rare case of ONM caused by a recurrent meningioma.

Case Description: A 56-year-old man presented with diplopia due to the right oculomotor nerve palsy caused by a sphenoidal atypical meningioma, with improved symptoms after initial surgery. Read More

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Hemichorea induced by a sphenoid ridge meningioma.

Surg Neurol Int 2021 3;12:201. Epub 2021 May 3.

Department of Neurosurgery, Kumamoto General Hospital, Yatsushiro, Japan.

Background: Movement disorders are rare in brain tumors. We describe a 45-year-old woman with hemichorea, a concomitant contralateral sphenoid ridge meningioma.

Case Description: The meningioma enlarged as her hemichorea worsened, and after meningioma resection, the hemichorea gradually subsided. Read More

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Intradural Extramedullary Primary Central Nervous System Melanoma of the Craniovertebral Junction during Pregnancy: Observations and Outcomes.

Surg Neurol Int 2021 3;12:198. Epub 2021 May 3.

Department of Surgery, University of Texas Rio Grande Valley, Edinburg, Texas, United States.

Background: Primary central nervous system (CNS) melanoma is a rare lesion derived from neural crest precursors. While its management is analogous to metastatic spinal melanoma, the literature does not describe this entity clearly in pregnant patients and the unique implications it presents. Here, we describe the case of a pregnant patient who presented with primary CNS melanoma of the cervical spine. Read More

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A rare appearance of the trigeminocardiac reflex during resection of posterior parasagittal meningioma.

Surg Neurol Int 2021 26;12:183. Epub 2021 Apr 26.

Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio, United States.

Background: Although a well-recognized phenomenon of the tentorium and posterior fossa, the trigeminocardiac reflex (TCR) has been rarely reported during surgery involving the posterior falx cerebri.

Case Description: We present the case of a 63-year-old woman who underwent repeat resection of an atypical parasagittal meningioma involving the posterior falx. During resection, TCR was repeatedly elicited during manipulation and coagulation of the falx. Read More

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Transport of patients with giant disfiguring cranial tumors from Africa to the US for collaborative multidisciplinary treatment.

Surg Neurol Int 2021 19;12:175. Epub 2021 Apr 19.

Department of Neurosurgery, National Brain Aneurysm and Tumor Center, Minneapolis, Minnesota, United States.

Background: Giant disfiguring cranial tumors are exceptionally rare and develop over the course of many years, typically in patients who lack access to medical care. Here, we describe four patients who were flown to our center for treatment by a multidisciplinary surgical team, who had previously been turned down for treatment at multiple international centers in Africa, Europe, and the United States (US) due to complexity and financial concerns. The case series describes socioeconomic implications and the feasibility of offering such care to patients from outside the US. Read More

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