J Neuropathol Exp Neurol 2021 Jun 12. Epub 2021 Jun 12.
Department of Pathology (C-HGL, PD, DAS, AP); Clinical Cancer Genomics Laboratory (PD), University of California, San Francisco, California, UUSA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA (CG); Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany (GR); Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA (SD); Department of Pathology, Sutter Medical Center, Sacramento (DC); Department of Neurological Surgery, University of California, San Francisco (AP), California, USA.
Anaplastic meningiomas can have a sarcomatous appearance on histology but true sarcomatous (metaplastic) differentiation is rare. These tumors follow an aggressive clinical course with recurrence and poor clinical outcomes. Due to significant overlap in morphology and immunohistochemical profiles, distinguishing between sarcomatous transformation of a meningioma and a true sarcoma can be challenging. Read More