22,242 results match your criteria Meningioma


Epithelioid Osteoblastoma of the Temporal Bone: A Case Report.

World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital.

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December 2018
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The clinicopathological analysis of receptor tyrosine kinases in meningiomas: the expression of VEGFR-2 in meningioma was associated with a higher WHO grade and shorter progression-free survival.

Brain Tumor Pathol 2018 Dec 5. Epub 2018 Dec 5.

Department of Pathology and Laboratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan.

WHO grade II/III meningiomas recur frequently and there is currently no established molecular target therapy for meningioma. No previous studies have revealed the association between receptor tyrosine kinases (RTKs) and the recurrence of meningiomas. This study aims to elucidate the association between RTKs and the clinicopathological characteristics and recurrence of meningioma. Read More

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December 2018

The application of fluorescence techniques in meningioma surgery-a review.

Neurosurg Rev 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurosurgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands.

Surgical resections of meningiomas, the most common intracranial tumor in adults, can only be curative if radical resection is achieved. Potentially, the extent of resection could be improved, especially in complex and/or high-grade meningiomas by fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA), indocyanine green (ICG), or fluorescein. This review aims to summarize and evaluate these fluorescence-guided meningioma surgery techniques. Read More

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December 2018

The prognostic significance of TERT promoter mutations in meningioma: a systematic review and meta-analysis.

J Neurooncol 2018 Dec 1. Epub 2018 Dec 1.

Department of Neurosurgery, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Background: Mutations in the telomerase reverse transcriptase promoter (TERTp) region have been associated with worse prognosis in some cancers. Meningiomas are the most common type of primary central nervous tumors, and evaluation of the prognostic significance of TERTp mutations across the literature is lacking. The aim of this study was to pool all current evidence to assess for clinical relevance of TERTp mutations in meningioma and survival effect. Read More

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December 2018

Improving results in patients with foramen magnum meningiomas by translating surgical experience into a classification system and complexity score.

Neurosurg Rev 2018 Dec 1. Epub 2018 Dec 1.

Department of Neurosurgery, International Neuroscience Institute, Rudolf Pichlmayr Str. 4, 30625, Hannover, Germany.

Foramen magnum meningiomas (FMMs) are challenging lesions and controversy still exists regarding their optimal management. In the present paper, we propose some principles of surgical treatment of FMMs. We analyzed our series of 39 patients: the average maximum diameter was 31. Read More

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December 2018

Meningiomas display a specific immunoexpression pattern in a rostrocaudal gradient: An analysis of 366 patients.

World Neurosurg 2018 Nov 29. Epub 2018 Nov 29.

Neurosurgery, School of Medicine. Electronic address:

Background: Meningiomas are heterogenous with differences in anatomical, histopathological and clinical characteristics. Such spatial variability in meningioma biology is thought to be due to differences in expression
of critical developmental regulators. We hypothesized that variability in meningioma biology follows gradients as in embryology and tested a cohort of 366 meningiomas for histopathological and immunohistochemical gradients. Read More

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November 2018

High p-mTOR expression is associated with recurrence and shorter disease-free survival in atypical meningiomas.

Neuropathology 2018 Dec 3. Epub 2018 Dec 3.

Biomedical and Odontoiatric Sciences, and of Morphological and Functional Images, University of Messina, Messina, Italy.

Due to their widely variable clinical behavior, the post-surgical treatment of atypical meningiomas is controversial. Therefore, prognostic factors able to identify high-risk cases, which may benefit from adjuvant treatments, are warranted. Mammalian target of rapamycin (mTOR) belongs to the PI3K-AKT pathway. Read More

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December 2018

Lateral intraventricular anaplastic meningioma: a series of 5 patients at a single institution and literature review.

World Neurosurg 2018 Nov 27. Epub 2018 Nov 27.

Department of Neurosurgery, West China Hospital, Sichuan University, 37 Guo Xue Xiang Street, Chengdu, 610041, P. R. China. Electronic address:

Objective: Lateral intraventricular anaplastic meningiomas (LIAMs) are rare lesions. The aim of this study is to clarify clinical and radiological characteristics, the optimal treatment strategies of LIAMs with long-term follow-up.

Patients And Methods: From September 2008 to September 2017, 5 LIAM patients were enrolled in our study. Read More

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November 2018
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Predictors of Unplanned Returns to the Operating Room within 30 Days in Neurosurgery: Insights from a National Surgical Registry.

World Neurosurg 2018 Nov 27. Epub 2018 Nov 27.

Mayo Clinic Neuro-Informatics Laboratory, Mayo Clinic College of Medicine and Science, Rochester, MN. Electronic address:

Background: In the modern, increasingly pay-for-performance era, unplanned ROR is gaining attention as a surgical quality metric. However, large-scale data on the appropriateness and utility of this measure in neurosurgery are scarce.

Objective: To provide a comprehensive description of all unplanned returns to the operating room (RORs) after neurosurgical procedures in a national surgical registry and identify factors associated with ROR. Read More

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November 2018
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Diffusion weighted imaging may help differentiate intracranial hemangiopericytoma from meningioma.

J Neuroradiol 2018 Nov 27. Epub 2018 Nov 27.

Department of Pathology, University of Manitoba, Winnipeg, Canada.

Background And Purpose: Hemangiopericytoma and meningioma appear similar on routine diagnostic imaging and hence are difficult to distinguish. The purpose of our study was to examine the diffusion weighted imaging (DWI) characteristics of these two types of tumours.

Methods: In a retrospective study, each patient with hemangiopericytoma was matched with two meningioma patients based on tumour location and size. Read More

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November 2018

Solitary fibrous tumor/hemangiopericytoma of the optic canal.

Clin Neuropathol 2018 Nov 30. Epub 2018 Nov 30.

Solitary fibrous tumor/hemangiopericytoma seldom arises from the optic nerve sheath. Herein, we describe the clinical, radiological, and histological findings of a solitary fibrous tumor/hemangiopericytoma arising from the optic nerve sheath and occupying the optic canal. The diagnosis is challenging both clinically and histologically as it clinically simulates a commoner lesion, i. Read More

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November 2018

Optic nerve sheath meningiomas: prevalence, impact, and management strategies.

Eye Brain 2018 24;10:85-99. Epub 2018 Oct 24.

Sydney Medical School, Discipline of Clinical Ophthalmology and Eye Health, University of Sydney, Sydney, NSW, Australia,

Optic nerve sheath meningiomas are rare benign neoplasms of the meninges surrounding the optic nerve. They are a significant cause of morbidity. While the mortality rate is practically zero, these tumors can blind or disfigure patients. Read More

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October 2018

Intracranial meningiomas: a systematic analysis of prognostic factors for recurrence in a large single institution surgical series.

World Neurosurg 2018 Nov 26. Epub 2018 Nov 26.

Neurosurgical Oncology Department, Humanitas University, Rozzano, Italy.

Background: Meningioma is the most common primary intracranial tumor. Surgical resection is the first choice of treatment, while the role of adjuvant radiotherapy (RT) is still unclear. Aim of the study was to evaluate prognostic factors influencing the local recurrence rate. Read More

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November 2018
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The Supra/Infra Transtentorial Transfalcine Approach for the Removal of a Falcotentorial Meningioma: 2-Dimensional Video.

Oper Neurosurg (Hagerstown) 2018 Nov 28. Epub 2018 Nov 28.

Director of Skull Base Program, Department of Neurological Surgery, Centro Médico Nacional 20 de Noviembre, ISSSTE, Mexico City, Mexico.

Falcotentorial meningiomas originate in the junction of the falx cerebri and the tentorium. Due to its anatomic vicinity, these tumors have a close relationship with important neurovascular structures surrounding the pineal region including the deep venous system. Surgical approaches would normally consider posterior midline corridors, but decision between supra or infratentorial access should be considered by the size, anatomic displacement of structures, and the infiltration of the dural attachment. Read More

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November 2018

Three types of dural suturing for closure of CSF leak after endoscopic transsphenoidal surgery.

Authors:

J Neurosurg 2018 Oct 1:1-7. Epub 2018 Oct 1.

OBJECTIVETranssphenoidal surgery (TSS) is commonly used for anterior skull base surgery, especially in the sella turcica (sellar) region. However, because of its anatomical position, CSF leakage is a major complication of this approach. The authors introduced a new grading reconstruction strategy for anterior skull base surgery with continuous dural suturing in 2013. Read More

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October 2018
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Epidemiology of meningiomas. A nationwide study of surgically treated tumours on French medico-administrative data.

Cancer Epidemiol 2018 Nov 24;58:63-70. Epub 2018 Nov 24.

Department of Medical Information, Georges Pompidou European Hospital, 75015, Paris, France.

Background: To describe the epidemiology of surgically treated meningiomas and compare the results with previously published studies.

Methods: We processed the French medico-administrative national hospital discharge summary database, Programme de Médicalisation des Systèmes d'Information (PMSI) using an algorithm combining the type of surgical procedure and codes from the International Classification of Diseases to retrieve appropriate cases of meningiomas operated between 2008 and 2016.

Results: This nationwide study found 25,737 cases of operated meningiomas. Read More

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November 2018
3 Reads

Dural based marginal zone lymphoma in a patient with sarcoidosis: a case report.

World Neurosurg 2018 Nov 23. Epub 2018 Nov 23.

Neuropathology Section, Department of Pathology and Molecular Medicine, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada. Electronic address:

Background: Primary dural based lymphoma is a rare disease entity. It has beenhypothesized that patients with sarcoidosis are at increased risk of developing lymphoma, an association known as "sarcoidosis-lymphoma syndrome", although dural disease has been not yet reported in the literature.

Case Description: Here we report the first case of dural based lymphoma in a 60-year-old; man with a history of sarcoidosis, in keeping with sarcoidosis-lymphoma syndrome. Read More

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November 2018
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Malpractice Litigation in Brain Tumor Surgery: A 31-Year Analysis of Causative Factors in the United States from the Westlaw Database.

World Neurosurg 2018 Nov 23. Epub 2018 Nov 23.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY.

Introduction: Medical malpractice litigation is an issue of major concern in neurosurgery, with 19.1% of neurosurgeons facing a claim annually. Neurosurgery possesses the greatest risk of malpractice of any specialty, likely due to the complex clinical environment and disease severity. Read More

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November 2018
6 Reads
2.417 Impact Factor

First-in-Man Clinical Experience Using a High-Definition 3-Dimensional Exoscope System for Microneurosurgery.

Oper Neurosurg (Hagerstown) 2018 Nov 26. Epub 2018 Nov 26.

Department of Neurosurgery, Lenox Hill Hospital, Zucker School of Medicine at Hofstra/Northwell, New York, New York.

Background: During its development and preclinical assessment, a novel, 3-dimensional (3D), high-definition (4K-HD) exoscope system was formerly shown to provide an immersive surgical experience, while maintaining a portable, low-profile design.

Objective: To assess the clinical applicability of this 3D 4K-HD exoscope via first-in-man surgical use.

Methods: The operative workflow, functionality, and visual haptics of the 3D 4K-HD exoscope were assessed in a variety of microneurosurgical cases at 2 US centers. Read More

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November 2018
5 Reads

Lesion symptom mapping at the regional level in patients with a meningioma.

Neuropsychology 2018 Nov 26. Epub 2018 Nov 26.

Department of Cognitive Neuropsychology, Tilburg University.

Objective: The majority of meningioma patients suffer from presurgical cognitive deficits. Since meningiomas do not directly damage the brain, this is presumably caused by a functional integrity reduction of the surrounding brain tissue through perilesional edema and/or mass effect of the tumor. Tumor location is a key feature in determining neurological symptoms in brain tumor patients, but the relationship between meningioma location and cognitive performance remains unclear. Read More

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November 2018

Microsurgical Gross Total Resection of a WHO Grade II Cerebellopontine Angle Ependymoma in an Adult.

J Neurol Surg B Skull Base 2018 Dec 25;79(Suppl 5):S426-S427. Epub 2018 Sep 25.

Department of Neurological Surgery, University of Wisconsin Medical School, Madison, Wisconsin, United States.

Infratentorial ependymomas that arise in the fourth ventricle and extend into the cerebellopontine angle (CPA) through the foramina of Luschka are well described. However, a primary CPA location of an ependymoma is distinctly uncommon. In this video, we present a 46-year-old man with episodes of dizziness, left-sided tinnitus, imbalance, double vision, and nausea. Read More

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December 2018
2 Reads

Multiple intracranial meningiomas: a case series and review of the literature.

World Neurosurg 2018 Nov 21. Epub 2018 Nov 21.

Departamento de Neurologia do Hospital das Clínicas da Universidade de São Paulo-SP, Brasil.

Objective: Review the data published on the subject to create a more comprehensive natural history of multiple meningiomas (MM).

Methods: a review of the MM published in the literature up to now was carried out through a Medline search up to August 2018. The use of the "multiple meningiomas" keyword returned 278 papers; and the parameters analyzed in our present cohort were searched on those publications. Read More

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November 2018
7 Reads

Neuro-Ophthalmic Disorders in Pregnancy.

Neurol Clin 2019 Feb;37(1):85-102

Department of Neurology, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA; Department of Ophthalmology, Massachusetts Eye and Ear, 243 Charles Street, Boston, MA 02114, USA. Electronic address:

The physiologic changes that accompany pregnancy can have important implications for neuro-ophthalmic disease. This article discusses pregnancy-related considerations for meningioma, pituitary disorders, demyelinating disease, myasthenia gravis, thyroid eye disease, idiopathic intracranial hypertension, cerebral venous sinus thrombosis, stroke, migraine, and cranial neuropathies. The article also details the potential neuro-ophthalmic complications of preeclampsia and eclampsia and reviews the use of common diagnostic studies during pregnancy. Read More

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February 2019
2 Reads

Clinical metric for differentiating intracranial hemangiopericytomas from meningiomas using diffusion weighted MRI.

Clin Imaging 2018 Nov 1;54:1-5. Epub 2018 Nov 1.

Department of Radiology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Lenox Hill Hospital, 100 East 77th Street, New York, NY 10075, USA.

Purpose: Intracranial Hemangiopericytomas (IHP) are dural based tumors that frequently recur/metastasize. Unfortunately, their imaging appearance overlaps significantly with more benign meningiomas. We evaluated the use of diffusion weighted imaging (DWI) to differentiate IHP from meningioma. Read More

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November 2018
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Risk factors and Associated Complications with Symptomatic Venous Thromboembolism in Patients with Craniotomy for Meningioma.

World Neurosurg 2018 Nov 20. Epub 2018 Nov 20.

Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY. Electronic address:

Objective: Patients undergoing surgical resection of meningioma are at increased risk for developing venous thromboembolism (VTE). The primary aim of this study was to assess the occurrence of VTE in patients who underwent surgery to remove their meningioma, and to determine the risk factors and associated complications with VTE.

Methods: The American College of Surgeons(ACS) National Surgical Quality Improvement Project (NSQIP) database from 2012-2015 was reviewed for patients who had undergone meningioma resection according to their primary Current Procedural Terminology codes and International Classification of Diseases, Ninth Revision. Read More

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November 2018
3 Reads
2.420 Impact Factor

Spinal meningioma surgery in the elderly: who benefits?

J Neurosurg Sci 2018 Nov 21. Epub 2018 Nov 21.

Department of Neurosurgery, University Hospital of Tuebingen, Tuebingen, Germany.

Background: With increasing life expectancy and increasing demands on quality of life more spinal meningiomas will limit quality of life in elderly in the coming decades. We investigated whether elderly can improve neurologically and gain self-dependence postoperatively.

Methods: Medical records of consecutive spinal meningioma patients from 2004 - 2015 were retrospectively analyzed. Read More

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November 2018
2 Reads

Predictive factors of complications post intracranial meningioma surgery leading to early unplanned reoperations - a single center study.

Folia Med Cracov 2018 ;58(2):5-13

Department of Neurosurgery and Neurotraumatology, Jagiellonian University Medical College, Botaniczna 3, Kraków, Poland.

Introduction: Complications occurring after neurosurgical procedures which lead to reoperations are associated with poor treatment outcomes. The aim of our study was to establish predictive factors of unplanned early reoperations after intracranial meningioma removal.

Materials And Methods: We retrospectively analyzed 177 patients who underwent craniotomy due to an intracranial meningioma. Read More

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January 2018

Atypical Intracranial Meningioma with Metastasis to C-7 Vertebral Body: A Case Report.

World Neurosurg 2018 Nov 19. Epub 2018 Nov 19.

Department of Neurosurgery, Medical College of Georgia at Augusta University. Electronic address:

Extracranial metastasis, mainly a feature of WHO grade III meningiomas, is only rarely reported in grade II meningiomas. We report a case of a 48-year-old man who was initially diagnosed in 2010 with an occipital convexity meningioma based on CT/MRI and treated with surgical therapy + gamma knife. The first operation achieved a macroscopically complete resection. Read More

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November 2018
2 Reads

Aural Polyp is not Always Due to Chronic Otitis Media (COM): Preoperative Computed Tomographic Scan is Good Pointer for Sinister Lesions.

Indian J Otolaryngol Head Neck Surg 2018 Dec 30;70(4):505-509. Epub 2018 Aug 30.

Department of Otorhinolaryngology, Pt. B.D. Sharma, PGIMS, Rohtak, Haryana India.

Twenty five patients of aural polyp who underwent canal wall down mastoidectomy were analysed retrospectively. Histopathological examination revealed cholesteatoma in 22 (88%) patients. However, histopathological diagnosis in 3 of these patients was unusual and rare benign tumors of the middle ear cleft-meningioma, neurilemmoma and capillary hemangioma. Read More

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December 2018
3 Reads

Isolated Intraventricular Rosai-Dorfman Disease.

Asian J Neurosurg 2018 Oct-Dec;13(4):1285-1287

Department of Pathology, Seth G. S. Medical College and K. E. M. Hospital, Mumbai, Maharashtra, India.

Rosai-Dorfman disease (RDD) is a benign histioproliferative disorder characterized by generalized lymphadenopathy, weakness, anemia, and rarely extranodal involvement. The disease affects the central nervous system (CNS) very rarely and at a relatively older age. Isolated intracranial involvement is very rare. Read More

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November 2018

Secondary Arachnoid Cyst - A Late Complication of Craniotomy: A Case Report and Review of Literature.

Asian J Neurosurg 2018 Oct-Dec;13(4):1273-1275

Department Of Neurosurgery, Dr. Soliman Fakeeh Hospital, Jeddah, Saudi Arabia.

Arachnoid cyst can be defined as cerebral-spinal fluid entrapment within the central nervous system. It may occur primarily as a congenital malformation or secondary as a complication following trauma, infection, bleeding, or surgical manipulation. Congenital arachnoid cyst usually asymptomatic and cause no pressure symptoms. Read More

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November 2018
5 Reads

Moulded Osteomyofascial Pedicled Split (MOPS) Craniotomy Flap in Reconstruction of Anterior Cranial Fossa Defects: Pilot Study of a Novel Technique.

Asian J Neurosurg 2018 Oct-Dec;13(4):1011-1017

Department of Neurosurgery, Government Medical College, Kottayam, Kerala, India.

Introduction: Anterior cranial fossa (ACF) defects still remains a reconstructive challenge to neurosurgeons due to the difficult location, inaccessibility, and unfavorable vascular anatomy. Usual reconstructive methods reported complications such as recurrent cerebrospinal fluid leak due to bone resorption and tissue breakdown. This is mainly due to the avascularity of the bone graft and inability to provide bony structural support for the skull base. Read More

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November 2018
8 Reads

Could the endocrine disruptor bisphenol-a be implicated in the pathogenesis of oral and oropharyngeal cancer? Metabolic considerations and future directions.

Metabolism 2018 Nov 17. Epub 2018 Nov 17.

Department of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias street, 11527 Athens, Greece. Electronic address:

Bisphenol-A (BPA), a prototype endocrine disrupting molecule, has been associated with many disease entities such as diabetes mellitus, obesity, polycystic ovarian disease, cardiovascular disease, reproductive and neurodevelopmental disorders. BPA has also been associated mainly with hormone sensitive cancers such as breast, prostate, endometrial, ovarian, testicular and thyroid cancers but also non-hormonal sensitive cancers such as cervical and lung cancers, osteosarcoma and meningioma. Recent research has investigated the sources of contamination which are responsible for higher BPA concentrations in the oral cavity and oropharyngeal space, representing the first site of BPA exposure after ingestion. Read More

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November 2018
2 Reads

Retrosigmoid Approach for Resection of Cerebellopontine Angle Meningioma.

J Neurol Surg B Skull Base 2018 Dec 25;79(Suppl 5):S407-S408. Epub 2018 Sep 25.

Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, United States.

This video depicts the case of an 81-year-old man who presented with a 3-month history of left-sided facial numbness and gait imbalance. On examination, he had gait ataxia and decreased left facial sensation in the V2 and V3 distribution. Magnetic resonance imaging (MRI) revealed a large homogenously enhancing lesion arising from the inferior surface of the tentorium toward the left cerebellopontine angle causing significant brainstem compression ( Fig. Read More

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December 2018
4 Reads

Trochlear Nerve Repair during Retrosigmoid Suprameatal Approach for Petrotentorial Meningioma: Operative Video.

J Neurol Surg B Skull Base 2018 Dec 1;79(Suppl 5):S404-S406. Epub 2018 Oct 1.

Department of Neurosurgery, Tokyo Medical University, Tokyo, Japan.

When operating on difficult skull base lesions, it is essential to be able to handle unexpected intraoperative findings or troubles, while achieving maximal lesion removal and minimal functional deficit. This video demonstrates a case of trochlear nerve repair that was performed during the retrosigmoid suprameatal approach for treatment of a petrotentorial meningioma, extending into the Meckel's cave. The patient is a 47-year-old woman with a right petrotentorial meningioma, extending into the Meckel's cave. Read More

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December 2018
1 Read

Combined Presigmoid and Retrosigmoid Approach to Petroclival Meningiomas.

J Neurol Surg B Skull Base 2018 Dec 25;79(Suppl 5):S402-S403. Epub 2018 Sep 25.

Department of Neurosurgery, Evangelic University Hospital of Curitiba, Parana, Brazil.

 The management of petroclival meningiomas is among the most intimidating in neurosurgery, due to its difficult accessibility and close relationship with vital structures; therefore, an appropriate exposure is mandatory. We present a surgical video demonstrating a presigmoid transtentorial approach, associated with the opening of the retrosigmoid dura to a petroclival meningioma, performed by the senior surgeon (L.A. Read More

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December 2018
3 Reads

Gross Total Resection of Large Cerebellopontine Angle Meningioma with a Supratentorial Extension via Retrosigmoid Approach with Suprameatal Drilling and Tentorial Sectioning.

J Neurol Surg B Skull Base 2018 Dec 25;79(Suppl 5):S399-S401. Epub 2018 Sep 25.

Department of Neurological Surgery, University of Wisconsin Medical School, Madison, Wisconsin, United States.

Meningiomas are the second most common neoplasm in the cerebellopontine angle (CPA), and are challenging lesions to treat surgically. With significant refinements in surgical techniques, operative morbidity, and mortality have been substantially reduced. Total or near-total surgical resection can be accomplished in the majority of cases via appropriately selected approaches, and with acceptable morbidity. Read More

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December 2018

Suboccipital Lateral Approach for Resection of Cerebellopontine Angle Meningioma: Operative Video and Technical Nuances.

J Neurol Surg B Skull Base 2018 Dec 9;79(Suppl 5):S397-S398. Epub 2018 Oct 9.

Department of Neurosurgery, Hospital Beneficência Portuguesa de São Paulo, Institute of Neurological Science of São Paulo, Bela Vista, São Paulo, Brasil.

We present the case of a 34-year-old woman, who presented to our department with a 4 months history of dizziness, hearing loss, and tinnitus on the right side. MRI (magnetic resonance imaging) scan demonstrated a large extra-axial lesion, suggestive of a meningioma, with dural attachments to the petrosal bone surface and tentorium, closely related with the trigeminal, abducens, facial, vestibulocochlear, and lower cranial nerves in the right side. Treatment options were discussed with the patient, and surgical resection was selected to remove the lesion, and decompress the cranial nerves and brainstem. Read More

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December 2018

Resection of a Petroclival Meningioma via the Endoscope-Assisted Retrosigmoid Approach: 2-D Operative Video.

J Neurol Surg B Skull Base 2018 Dec 1;79(Suppl 5):S395-S396. Epub 2018 Oct 1.

Department of Neurological Surgery, Eberhard-Karls University, University Hospital Tübingen, Tübingen, Germany.

We present a case of a petroclival meningioma that was resected through an endoscope-assisted retrosigmoid approach via corridors above and below the facial-vestibulocochlear nerve complex. The patient is a 61-year-old female with complaints of left-sided hypesthesia and neuralgia of the infraorbital and zygomatic region, intermittent periorbital myokymia, and a slight facial palsy (HB II). This 2D video demonstrates the operative technique, anatomical and surgical nuances of the skull base approach and microdissection of the tumor from the critical neurovascular structures. Read More

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December 2018
1 Read

Red Blood Cell Transfusions Following Resection of Skull Base Meningiomas: Risk Factors and Clinical Outcomes.

J Neurol Surg B Skull Base 2018 Dec 14;79(6):599-605. Epub 2018 May 14.

Department of Neurosurgery, Ronald Reagan UCLA Medical Center, Los Angeles, California, United States.

 This article identifies risk factors for and investigates clinical outcomes of postoperative red blood cell transfusion in patients with skull base meningiomas.  Retrospective cohort study.  Single academic medical center. Read More

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December 2018
1 Read

Machine learning analyses can differentiate meningioma grade by features on magnetic resonance imaging.

Authors:

Neurosurg Focus 2018 Nov;45(5):E4

OBJECTIVEPrognostication and surgical planning for WHO grade I versus grade II meningioma requires thoughtful decision-making based on radiographic evidence, among other factors. Although conventional statistical models such as logistic regression are useful, machine learning (ML) algorithms are often more predictive, have higher discriminative ability, and can learn from new data. The authors used conventional statistical models and an array of ML algorithms to predict atypical meningioma based on radiologist-interpreted preoperative MRI findings. Read More

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November 2018
1 Read

Combined Transpetrosal Approach With Preservation of Superior Petrosal Vein Drainage for a Cerebellopontine Angle Epidermoid Cyst Extending Into Meckel's Cave: 3-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Nov 18. Epub 2018 Nov 18.

Department of Neurosurgery, Tokyo Medical University, Tokyo, Japan.

The combined transpetrosal approach enables wide exposure around the petroclival region by cutting the tentorium and superior petrosal sinus. We often choose this approach for removal of tumors ventral to the facial and vestibulocochlear nerves, such as petroclival meningioma and epidermoid cyst, because complete removal of the tumor under direct visualization is required to prevent its later recurrence, especially in young patients. Recent reports revealed anatomical variations of the drainage of the superior petrosal sinus, and dural incision considering preservation of the superior petrosal vein was proposed. Read More

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November 2018

Preoperative grading of intracranial meningioma by magnetic resonance spectroscopy (1H-MRS).

PLoS One 2018 19;13(11):e0207612. Epub 2018 Nov 19.

Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Although proton magnetic resonance spectroscopy (1H-MRS) is a common method for the evaluation of intracranial meningiomas, controversy exists regarding which parameter of 1H-MRS best predicts the histopathological grade of an intracranial meningioma. In this study, we evaluated the results of pre-operative 1H-MRS to identify predictive factors for high-grade intracranial meningioma. Thirteen patients with World Health Organization (WHO) grade II-III meningioma (confirmed by pathology) were defined as high-grade; twenty-two patients with WHO grade I meningioma were defined as low-grade. Read More

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November 2018
4 Reads

An unusual case of a grade I meningioma with perineural spread.

Br J Neurosurg 2018 Nov 19:1-4. Epub 2018 Nov 19.

a Department of Neurosurgery , NHS Tayside , Dundee , United Kingdom.

A 39-year-old lady with worsening intermittent diplopia and headaches was diagnosed with a WHO Grade I Meningothelial Meningioma with highly unusual perineural spread on imaging, making this the first reported case of this behaviour. Complete surgical resection was deemed too great a risk and the patient remains under observation. The process of perineural spread is not restricted to more aggressive brain tumours. Read More

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November 2018
1 Read

Management of meningioma.

Presse Med 2018 Nov 15. Epub 2018 Nov 15.

Hôpital Pitié-Salpêtrière, service de Neurochirurgie, 75013 Paris, France; CRICM INSERM U1127 CNRS UMR 7225, Institut du Cerveau et de la Moelle épinière, Unité de Neuro-oncologie expérimentale, 75013 Paris, France; Sorbonne Universités, Paris, France.

Meningiomas are the most frequent primary brain tumors, accounting for ∼37% of central nervous systems tumors. Despite being largely benign, clinicians frequently face difficult treatment decisions in cases with complex morphology or localisation, near vital brain structures such as the optic nerve or in the case of incidental tumors. Here, we review current concepts of diagnosis, treatment and follow-up with clinical decision-making informed by multimodal imaging, histology, and molecular biology. Read More

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November 2018

Long-Term Outcomes of Newly-Diagnosed Resected Atypical Meningiomas and the Role of Adjuvant Radiotherapy (ART).

World Neurosurg 2018 Nov 14. Epub 2018 Nov 14.

Department Radiation Oncology, Kaiser Permanente - Los Angeles Medical Center, 4950 Sunset Blvd, Los Angeles, CA, 90027, USA.

Objective: The role of adjuvant radiotherapy (ART) in patients with WHO Grade II atypical meningiomas (AM) remains controversial.

Methods: We retrospectively reviewed 149 patients with newly-diagnosed, resected AMs from 2000-2012. Gross total resection (GTR) was defined as Simpson Grade I-III and subtotal resection (STR) as Grade IV-V. Read More

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November 2018
1 Read

A Case Report of Meningeal Hemangiopericytoma: A nine-year journey from the brain to the spine.

World Neurosurg 2018 Nov 14. Epub 2018 Nov 14.

Division of Neurosurgery, Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut, Lebanon. Electronic address:

Background And Importance: Hemangiopericytomas (HPC) are rare and aggressive vascular mesenchymal tumors. Unlike meningiomas which have a similar radiological appearance, these tumors have a higher risk of local recurrence after resection, and distant metastasis can reach up to 23%. Metastases to the vertebral bones from an intracranial HPC are very rare, with so far only 9 cases reported in the literature. Read More

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November 2018
5 Reads

Treatment protocol, long-term follow-up, and predictors of mortality in 302 cases of atypical meningioma.

World Neurosurg 2018 Nov 14. Epub 2018 Nov 14.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University. TiantanXili 6, Dongcheng District, Beijing, 100050, People's Republic of China; China National Clinical Research Center for Neurological Diseases, Beijing, China; Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China; Beijing Key Laboratory of Brain Tumor, Beijing, China. Electronic address:

Objective: Despite the paucity of relevant data, treatment and outcomes in intracranial atypical meningioma (AM) remain unclear. The aim of this study was to find useful factors predicting survival and to evaluate the role of postoperative radiation (PRT ) following surgery.

Methods: Data were obtained from 302 patients with AM who received surgery between January 2008 and December 2015. Read More

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November 2018
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Acquired mania associated with a left temporal meningioma.

Bipolar Disord 2018 Nov 16. Epub 2018 Nov 16.

Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.

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November 2018
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