7,572 results match your criteria Meniere Disease


Intratympanic steroid versus gentamicin for treatment of refractory Meniere's disease: A meta-analysis.

Am J Otolaryngol 2021 May 21;42(6):103086. Epub 2021 May 21.

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address:

Purpose: Intratympanic steroid injections (ITSI) have become a promising treatment for refractory Meniere's disease due to less cochleovestibular damage. However, whether ITSI would be a good alternative to intratympanic gentamicin injections (ITGI) for refractory Meniere's disease still remains controversial. Here we intended to compare the therapeutic effect of ITSI and ITGI in patients with Meniere's disease refractory to conservative treatments, in terms of vertigo control and hearing outcomes, via a meta-analysis. Read More

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MRI With Gadolinium as a Measure of Blood-Labyrinth Barrier Integrity in Patients With Inner Ear Symptoms: A Scoping Review.

Front Neurol 2021 20;12:662264. Epub 2021 May 20.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Capillaries within the inner ear form a semi-permeable barrier called the blood-labyrinth barrier that is less permeable than capillary barriers elsewhere within the human body. Dysfunction of the blood-labyrinth barrier has been proposed as a mechanism for several audio-vestibular disorders. There has been interest in using magnetic resonance imaging (MRI) with intravenous gadolinium-based contrast agents (GBCA) as a marker for the integrity of the blood labyrinth barrier in research and clinical settings. Read More

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Enhanced Eye Velocity in Head Impulse Testing-A Possible Indicator of Endolymphatic Hydrops.

Front Surg 2021 7;8:666390. Epub 2021 May 7.

Vestibular Research Laboratory, School of Psychology, The University of Sydney, Sydney, NSW, Australia.

On video head impulse testing (vHIT) of semicircular canal function, some patients reliably show enhanced eye velocity and so VOR gains >1.0. Modeling and imaging indicate this could be due to endolymphatic hydrops. Read More

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[Studies of brain function associated with otogenic vertigo].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 May;56(5):517-521

Department of Otorhinolaryngology Head and Neck Surgery, Sixth People's Hospital, Shanghai Jiaotong University,Shanghai 200233, China.

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Wideband tympanometry as a diagnostic tool for Meniere's disease: a retrospective case-control study.

Eur Arch Otorhinolaryngol 2021 May 19. Epub 2021 May 19.

Department of Otolaryngology, Head and Neck Surgery and Audiology, Aalborg University Hospital, Aalborg, Denmark.

Purpose: The main purpose of this study was to investigate the usefulness of wide band tympanometry (WBT) as a diagnostic tool for Ménière's disease (MD) by comparing differences in absorbance measures between normal hearing ears and patient diagnosed with MD.

Methods: We conducted a retrospective case-control study. From a cohort of 116 patients diagnosed with Ménière disease, 52 MD patients and 99 normal hearing adults with no history of otological disease served as subjects. Read More

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Styloidogenic-cervical spondylotic internal jugular venous compression, a vascular disease related to several clinical neurological manifestations: diagnosis and treatment-a comprehensive literature review.

Ann Transl Med 2021 Apr;9(8):718

Neurosurgery Department, Sant'Anna University Hospital, Ferrara, Italy.

Internal jugular vein (IJV) stenosis is associated with several central nervous system disorders such as Ménière or Alzheimer's disease. The extrinsic compression between the styloid process and the C1 transverse process, is an emerging biomarker related to several clinical manifestations. However, nowadays a limited number of cases are reported, and few information are available about treatment, outcome and complications. Read More

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Magnetic resonance imaging of the inner ear in the diagnostics of Ménière's disease.

Otolaryngol Pol 2020 Dec;75(2):1-8

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, Poland; Head: Prof. Kazimierz Niemczyk MD PhD.

Ménière's disease is characterized by sudden episodes of vertigo accompanied by tinnitus and/or feeling of fullness in the ear as well as fluctuating sensorineural hearing loss. Despite numerous studies, the etiology of this disease remains unknown. However, the enlargement of the inner ear's endolymphatic spaces, referred to as endolymphatic hydrops, is considered the underlying condition. Read More

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December 2020

[Betahistine in vestibular disorders: current concepts and perspectives].

Vestn Otorinolaringol 2021 ;86(2):73-81

Federal Siberian Research Clinical Centre under the Federal Medical Biological Agency, Krasnoyarsk, Russia.

The goal of this paper is to review the pharmacological profile of betahistine and evidence for using it in the treatment of common vestibular disorders. Betahistine is a weak agonist for histamine H1 receptors and strong antagonist for histamine H3 receptors. It demonstrates the maximum benefit in different types of peripheral vertigo, especially in Meniere's disease. Read More

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Association between Chronic Obstructive Pulmonary Disease and Ménière's Disease: A Nested Case-Control Study Using a National Health Screening Cohort.

Int J Environ Res Public Health 2021 04 24;18(9). Epub 2021 Apr 24.

Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea.

This study explored the relation between Ménière's disease and chronic obstructive pulmonary disease (COPD). The ≥40-year-old population of the Korean National Health Insurance Service-Health Screening Cohort was included. In total, 7734 Ménière's disease patients and 30,936 control participants were enrolled. Read More

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[Episodic vestibular syndrome].

Ugeskr Laeger 2021 04;183(15)

Dizziness and vertigo are frequent symptoms in the primary care facility and emergency departments. Episodic vestibular syndrome (EVS) is defined as episodic dizziness, vertigo or postural imbalance with remission between episodes. EVS can be divided into spontaneous (s-EVS) and triggered EVS (t-EVS). Read More

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Prosper Menière: the man who located vertigo in the inner ear.

Arq Neuropsiquiatr 2021 03;79(3):254-256

Hospital Naval Marcílio Dias, Rio de Janeiro RJ, Brazil.

Since the Greek Aellus Galenum (129 AD - c.200/c.216), vertigo was considered a problem attributed to a cerebral disorder, diagnosed as the manifestation of apoplectiform cerebral congestion. Read More

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Correlation between magnetic resonance imaging classification of endolymphatic hydrops and clinical manifestations and audiovestibular test results in patients with definite Ménière's disease.

Auris Nasus Larynx 2021 Apr 14. Epub 2021 Apr 14.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, Poland.

Objectives: The purpose was to evaluate magnetic resonance imaging (MRI) classification of endolymphatic hydrops with clinical features, audiological and vestibular tests in patients with definite unilateral Ménière's disease (MD).

Methods: Thirty-eight patients were enrolled in this study. The severity of the main clinical symptoms, audiovestibular tests, and MRI, performed 4 hours after intravenous injection of gadobutrol to visualize inner ear compartments, were evaluated. Read More

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Effectiveness of intratympanic dexamethasone for the treatment of vertigo attacks in patients with Ménière's disease compared with betahistine pharmacotherapy.

J Int Med Res 2021 Apr;49(4):300060520985647

37637Semmelweis University, Department of Otolaryngology and Head and Neck Surgery, Budapest, Hungary.

Objective: This study analyzed the possible effects of intratympanic steroid (ITS) therapy in the symptomatic treatment of vertigo attacks in patients with Ménière's disease.

Methods: Thirty-five patients treated with ITS (dexamethasone) plus betahistine (Group A) and 35 patients treated with betahistine alone (Group B) were enrolled in this investigation. Complaints were analyzed using medical records and vertigo diaries. Read More

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Case Report: Positive Pressure Therapy Combined With Endolymphatic sac Surgery in a Patient With Ménière's Disease.

Front Surg 2021 25;8:606100. Epub 2021 Mar 25.

Department of Otolaryngology, University of Tokushima School of Medicine, Tokushima, Japan.

Positive pressure therapy (PPT) is applied for medically-intractable vertigo in Ménière's disease (MD); however, it remains unknown whether PPT affects endolymphatic hydrops (EH). In this case report, we describe a 5-year course of MD in a patient in which EH was repeatedly observed. As the patient experienced recurrent vertigo attacks after endolymphatic sac surgery, he began to use the PPT device additionally and vertiginous episodes decreased in accordance with a decrease in the EH volume. Read More

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Comparison of inner ear MRI enhancement in patients with Meniere's disease after intravenous injection of gadobutrol, gadoterate meglumine, or gadodiamide.

Eur J Radiol 2021 Jun 26;139:109682. Epub 2021 Mar 26.

Department of Radiology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China. Electronic address:

Purpose: To compare the enhancement results of three gadolinium contrast agents in the inner ear of patients with Meniere's disease 4 h after intravenous injection of gadobutrol, gadoterate meglumine, or gadodiamide.

Methods: We enrolled 60 patients with a definitive diagnosis of unilateral Meniere's disease and divided them into three groups of 20 patients; each group received a double dose of gadobutrol, gadoterate meglumine, or gadodiamide. The postcontrast signal intensity of the basal cochlear turn was scored quantitatively, and qualitative visual evaluation of the cochlea, vestibule and semi-circular canals was also performed. Read More

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Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study.

EBioMedicine 2021 Apr 1;66:103309. Epub 2021 Apr 1.

Otology & Neurotology Group CTS495, Department of Genomic Medicine, GENYO-Centre for Genomics and Oncological Research-Pfizer/University of Granada/ Junta de Andalucía, PTS, Granada, Spain; Department of Otolaryngology, Instituto de Investigación Biosanitaria, ibs.Granada, Hospital Universitario Virgen de las Nieves, Granada, Spain; Department of Surgery, Division of Otolaryngology, University of Granada, Granada, Spain. Electronic address:

Background: tinnitus is a heterogeneous condition associated with audiological and/or mental disorders. Chronic, severe tinnitus is reported in 1% of the population and it shows a relevant heritability, according to twins, adoptees and familial aggregation studies. The genetic contribution to severe tinnitus is unknown since large genomic studies include individuals with self-reported tinnitus and large heterogeneity in the phenotype. Read More

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The relationship between clinical characteristics and magnetic resonance imaging results of Ménière disease: a prospective study.

Sci Rep 2021 Mar 30;11(1):7212. Epub 2021 Mar 30.

Department of Otolaryngology, Head and Neck Surgery & Audiology and Neurotology, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden.

Ménière disease (MD) is an idiopathic inner ear disorder, and endolymphatic hydrops (EH) being considered to be its pathological basis. Currently, there is no gold standard for diagnosing MD. Previous study has reported visualized EH using MRI by intratympanic gadolinium-based contrast media (GBCM) administration (IT-Gd) in patients with MD, and this technique was gradually established for MD diagnosis. Read More

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Endolymphatic Hydrops in Patients With Vestibular Migraine and Concurrent Meniere's Disease.

Front Neurol 2021 11;12:594481. Epub 2021 Mar 11.

Department of Neurology, University Hospital, Ludwig-Maximilians-Universität, Munich, Germany.

Intravenous contrast agent enhanced, high-resolution magnetic resonance imaging of the inner ear (iMRI) confirmed that patients with Menière's disease (MD) and vestibular migraine (VM) could present with endolymphatic hydrops (EH). The present study aimed to investigate EH characteristics and their interrelation to neurotologic testing in patients with VM, MD, or VM with concurrent MD (VM-MD). Sixty-two patients (45 females, aged 23-81 years) with definite or probable VM ( = 25, 19 definite), MD ( = 29, 17 definite), or showing characteristics of both diseases ( = 8) were included in this study. Read More

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The relationship between nutrition and Ménière's disease.

Auris Nasus Larynx 2021 Mar 24. Epub 2021 Mar 24.

Department of Audiology, Faculty of Health Sciences, Marmara University, Istanbul, Turkey. Electronic address:

Ménière's disease is an inner ear disease with attacks characterized by ear fullness, tinnitus, fluctuant sensorineural hearing loss and vertigo. Although pathophysiology of the disease is not fully known, endolymphatic hydrops are believed to play a role. Although there is no certain treatment procedure for Ménière's disease, some treatments are applied to prevent attacks, to treat the symptoms that occur during the attacks, and to prevent the permanent effects of the symptoms on the hearing and balance system. Read More

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Vertigo without cochlear symptoms: vestibular migraine or Menière disease?

Neurol Sci 2021 Mar 25. Epub 2021 Mar 25.

Department of Otolaryngology Head & Neck Surgery, IRCCS San Raffaele Scientific Institute, San Raffaele Hospital, Via Olgettina 60, 20132, Milan, Italy.

Background: Menière's disease (MD) is an inner ear disorder due to raised endolymphatic pressure (hydrops), characterized by cochlear symptoms associated with episodic vertigo. In delayed hydrops, vertigo attacks begin long after the onset of a hearing loss. Few were published on MD in which the onset of vertigo precedes cochlear symptoms by several months. Read More

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Beethoven's influence on Rokitansky's methodology : "The facial nerves were of considerable thickness; the auditory nerves, on the other hand, were shrunk and marrowless".

Wien Med Wochenschr 2021 Mar 25. Epub 2021 Mar 25.

Arbeitsgruppe Geschichte der Medizin und Medical Humanities, Kommission für Geschichte und Philosophie der Wissenschaften an der Österreichischen Akademie der Wissenschaften, Vienna, Austria.

Prompted by the autopsy of Ludwig van Beethoven (1770-1827) to seek the origins of disease in a changed anatomy, Carl Freiherr von Rokitansky (1804-1878) initiated a paradigm shift from speculative natural philosophical medicine to systematic scientific medicine. Until then, autopsy reports usually contained clinical observations as well as the diagnosis of the attending physician, which the pathologist merely supplemented with a description of the corpse. Influenced by Rokitansky's search for scientific explanations for disease, pathology evolved from a descriptive to an explanatory science from the early 1830s onwards. Read More

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[Positional vertigo variant].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(2):88-91

Central Research Institute for Dentistry and Maxillofacial Surgery, Moscow, Russia.

The article describes case history and multiphase treatment of the patient with attacks of vertigo, initially regarded as the onset of Meniere's disease, but later qualified as secondary positional attacks with combined musculoskeletal pathology of the craniovertebral region and temporomandibular joint. Medicinal, local and surgical treatment led to the perfect result. Thus, the team work of neurologist, otolaryngologist, maxillofacial surgeon and orthodontist led to the successful elimination of vertigo attacks. Read More

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[Various types of vertigo and balance disorders in patients with Meniere's disease].

Vestn Otorinolaringol 2021 ;86(1):90-95

Russian Medical Academy of Continuous Professional Education, Moscow, Russia.

Vertigo and balance disorders in Meniere's disease (MD) may have various etiology. The aim of the review is discussing pathogenetic mechanisms of the typical vertiginous paroxysms in MD, resulting from endolymphatic hydrops as well as analysis of etiology, pathogenesis, clinical course and basic treatment of paroxysmal and permanent forms of vertigo and balance disorders, caused by other conditions, associated with MD. We discussed the course of MD complicated by vestibular migraine, benign positional paroxysmal vertigo, functional dizziness, bilateral vestibulopathy and vestibular drop-attacks. Read More

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Which Inner Ear Disorders Lie Behind a Selective Posterior Semicircular Canal Hypofunction on Video Head Impulse Test?

Otol Neurotol 2021 04;42(4):573-584

ENT & Audiology Unit, Department of Diagnostic, Experimental and Specialty Medicine (DIMES), S.Orsola - Malpighi University Hospital, Bologna.

Objective: To assess all different patterns of associated abnormalities on audiometry, bithermal caloric test (BCT) and cervical/ocular vestibular-evoked myogenic potentials (VEMPs) to air/bone-conduction in patients with selective posterior semicircular canal (PSC) hypofunction and to correlate them with underlying disorders.

Study Design: Retrospective review.

Setting: Tertiary referral center. Read More

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Is Menière's Disease a Contraindication to Stapedectomy?

Otol Neurotol 2021 04;42(4):e393-e398

Department of Neurotology, Michigan Ear Institute, St. John Providence Hospital and Medical Centers, Farmington Hills, Michigan.

Objective: Review surgical outcomes of stapedectomy for otosclerosis in patients with Menierè's disease.

Study Design: Retrospective case review.

Setting: Tertiary referral center. Read More

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Clinical high-resolution imaging and grading of endolymphatic hydrops in Hydropic Ear Disease at 1.5 T using the two-slice grading for vestibular endolymphatic hydrops in less than 10 min.

Eur Arch Otorhinolaryngol 2021 Mar 9. Epub 2021 Mar 9.

Clinical Audiology and Vestibulology Laboratory, State Institution "O.S. Kolomiychenko Institute of Otolaryngology National Academy of Medical Sciences of Ukraine", Kiev, Ukraine.

Background: Hydropic Ear Disease (Menière) is one of the most common inner ear disorders and one of the most common causes of vertigo attacks. The underlying pathology is a distension of the endolymphatic space of the inner ear, termed endolymphatic hydrops. However, the unequivocal morphologic confirmation of ELH has been restricted to post-mortem histologic analysis until 2007, when the first clinical MR imaging report demonstrated ELH in living patients with Menière's disease at 3 T combined with intratympanic application of contrast. Read More

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Patients with non-idiopathic sudden sensorineural hearing loss show hearing improvement more often than patients with idiopathic sudden sensorineural hearing loss.

Eur Arch Otorhinolaryngol 2021 Mar 8. Epub 2021 Mar 8.

Department of Otorhinolaryngology, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.

Introduction: To compare inpatient treated patients with idiopathic (ISSNHL) and non-idiopathic sudden sensorineural hearing loss (NISSNHL) regarding frequency, hearing loss, treatment and outcome.

Methods: All 574 inpatient patients (51% male, median age: 60 years) with ISSNHL and NISSNHL, who were treated in federal state Thuringia in 2011 and 2012, were included retrospectively. Univariate and multivariate statistical analyses were performed. Read More

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Development of ebselen for the treatment of sensorineural hearing loss and tinnitus.

Hear Res 2021 Feb 19:108209. Epub 2021 Feb 19.

Sound Pharmaceuticals Inc, 4010 Stone Way N, Suite 120, Seattle, WA 98103, United States.

The global impact of hearing loss and related auditory dysfunction including tinnitus and hyperacusis on human health is significant and growing. A substantial body of literature has found that these hearing diseases and disorders result from significant number of genetic variations and molecular mechanisms. Investigational new drugs have been tested and several approved drugs have been repurposed in clinical trials, but no therapeutics for any auditory related indication have been FDA approved. Read More

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February 2021

Alexithymia in Patients with Ménière Disease: A Possible Role on Anxiety and Depression.

Audiol Res 2021 Feb 23;11(1):63-72. Epub 2021 Feb 23.

Clinical Healt Psychology Unit, IRCCS San Raffaele Hospital, 20132 Milan, Italy.

The aim of this paper was to investigate the role of the psychological variable of alexithymia both as a risk factor for the development of Ménière's disease (MD) and as a component that influences the personal experience of MD and the individual quality of life. We collected data from 179 Italian patients who fulfilled criteria for definite MD. Patients filled out validated self-rating questionnaires to assess alexithymia (TAS-20), quality of life (WHOQOL-BREF), anxiety and depression (HADS), perception of stress (PSS) and coping strategies (COPE). Read More

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February 2021

Vestibular drop attacks in Ménière's disease.

J Vestib Res 2021 Feb 26. Epub 2021 Feb 26.

Department of Speech and Hearing Sciences, Lamar University, Beaumont, Texas, USA.

The aim of the present study was to evaluate the severity of vestibular drop attack (VDA) in Ménière's disease (MD) and to examine the association between VDA severity and other MD-related complaints. The study used a cross-sectional survey design using an electronic questionnaire. The mean age of participants was 56. Read More

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February 2021