7,823 results match your criteria Meniere Disease

New Genetic Variants in and Support the Role of Oxidative Stress in Familial Ménière's Disease.

Genes (Basel) 2022 Jun 1;13(6). Epub 2022 Jun 1.

Center for Life-Course Health Research, Faculty of Medicine, University of Oulu, Finland and Oulu City Hospital, 90220 Oulu, Finland.

The objective was to study the genetic etiology of Ménière's disease (MD) using next-generation sequencing in three families with three cases of MD. Whole exome sequencing was used to identify rare genetic variants co-segregating with MD in Finnish families. In silico estimations and population databases were used to estimate the frequency and pathogenicity of the variants. Read More

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Predicting neural deficits in sensorineural hearing loss from word recognition scores.

Sci Rep 2022 Jun 23;12(1):8929. Epub 2022 Jun 23.

Eaton-Peabody Laboratories, Massachusetts Eye & Ear, 243 Charles Street, Boston, MA, 02114-3096, USA.

The current gold standard of clinical hearing assessment includes a pure-tone audiogram combined with a word recognition task. This retrospective study tests the hypothesis that deficits in word recognition that cannot be explained by loss in audibility or cognition may reflect underlying cochlear nerve degeneration (CND). We collected the audiological data of nearly 96,000 ears from patients with normal hearing, conductive hearing loss (CHL) and a variety of sensorineural etiologies including (1) age-related hearing loss (ARHL); (2) neuropathy related to vestibular schwannoma or neurofibromatosis of type 2; (3) Ménière's disease; (4) sudden sensorineural hearing loss (SSNHL), (5) exposure to ototoxic drugs (carboplatin and/or cisplatin, vancomycin or gentamicin) or (6) noise damage including those with a 4-kHz "noise notch" or reporting occupational or recreational noise exposure. Read More

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Quality of life after intratympanic steroid injection for Ménière's disease.

Laryngoscope Investig Otolaryngol 2022 Jun 17;7(3):825-831. Epub 2022 May 17.

Department of Otorhinolaryngology HagaHospital The Hague The Netherlands.

Objective: This study explores how treatment with intratympanic steroid injection affects quality of life, as well as several subjective complaints in patients with Ménière's disease.

Methods: Patients filled in the Ménière's Disease Outcome Questionnaire (MDOQ) and answered questions about subjective complaints. Scores before and after treatment were compared using paired tests. Read More

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Dizziness in the Emergency Department: Insights and Epidemiological Data - a Population Based Study.

Maedica (Bucur) 2022 Mar;17(1):122-128

Faculty of Medicine, Department of Internal Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.

Dizziness is a commonly referred symptom in emergency departments (EDs). The aim of this study is to describe the epidemiology of dizziness included acute vestibular syndrome (AVS) in the ED of the University Hospital of Ioannina, Grecce, during a six-month period. A total of 60 patients presenting with dizziness to the ED of our hospital during a short period of six months in 2021 were identified. Read More

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Defective α-tectorin may involve tectorial membrane in familial Meniere disease.

Clin Transl Med 2022 Jun;12(6):e829

Otology & Neurotology Group CTS 495, Department of Genomic Medicine, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain.

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Endolymphatic hydrops presumption tests for patients with vestibular migraine.

Acta Otolaryngol 2022 May 1;142(5):406-409. Epub 2022 Jun 1.

Department of Otolaryngology, St Marianna University School of Medicine, Yokohama, Japan.

Background: The aetiology of vestibular migraine (VM) has not yet been defined; endolymphatic hydrops (EH) has been suggested as a candidate.

Objectives: This study aimed to clarify the relationship between VM and EH using neuro-otological tests, including the EH presumption test.

Materials And Methods: Fourteen patients with VM underwent caloric testing, video head impulse test (vHIT), cervical and ocular vestibular evoked myogenic potential (cVEMP and oVEMP), and EH presumption tests such as the Futaki's test and furosemide loading VEMP. Read More

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[New discovery and short-term effect analysis of tensor tympani muscle tenotomy for Meniere's disease under otoscope].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 May;57(5):602-606

Department of Otorhinolaryngology, Liaocheng People's Hospital, Liaocheng 252000, China.

To explore the feasibility and short-term effect of tensor tympani muscle Tenotomy in the treatment of Meniere's disease under otoscope. The possible pathogenesis was discussed and our views were put forward. The clinical data of 9 cases of Meniere's disease treated by otoscopic Tenotomy were analyzed retrospectively, including 2 males, 7 females, 5 right ones, 2 left ones and 2 bilateral ones. Read More

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Is Inadequate Water Intake a Risk Factor for Vestibular Disorders?

J Int Adv Otol 2022 May;18(3):264-268

Department of Audiology, Hacettepe University Faculty of Health Sciences, Ankara, Turkey.

Background: Water is a vital nutrient for the human body system and failing to consume enough water could cause health problems. The purpose of this study is to investigate the relationship between water intake and vestibular system disorders.

Methods: Data from 93 patients (aged between 20 and 76 years) with vestibular disorders were analyzed in the study. Read More

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Population-based study for the comorbidities and associated factors in Ménière's disease.

Min Hee Kim

Sci Rep 2022 May 18;12(1):8266. Epub 2022 May 18.

Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, Kyung Hee University Hospital at Gangdong, Dongnam-ro 892, Seoul, 05278, Republic of Korea.

To date, no study has reported the objective metabolic laboratory findings worldwide or the comorbidities for Ménière's disease (MD) using a population-based design in Asian populations. The aim of this study was to investigate the comorbidities and associated factors for MD using the Korean National Health Insurance Service database. This retrospective population-based study was conducted using a data from the National Sample Cohort database from 2009 to 2015. Read More

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Consensus on MR Imaging of Endolymphatic Hydrops in Patients With Suspected Hydropic Ear Disease (Meniere).

Front Surg 2022 28;9:874971. Epub 2022 Apr 28.

Ear Nose and Throat Patient Area, Trauma and Reparative Medicine Theme, Karolinska University Hospital, Stockholm, Sweden.

Endolymphatic hydrops (EH) is considered the histological hallmark of Meniere's disease. Visualization of EH has been achieved by special sequences of inner ear magnetic resonance imaging (MRI) with a gadolinium-based contrast agent intravenous or intratympanic administration. Although it has been applied for more than 10 years since 2007, a unified view on this technique has not yet been achieved. Read More

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Editorial: Hydropic Ear Disease: Imaging and Functional Evaluation.

Shinji Naganawa

Front Surg 2022 27;9:913741. Epub 2022 Apr 27.

Department of Radiology, Graduate School of Medicine, Nagoya University, Nagoya, Japan.

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Non-contrast MRI of Inner Ear Detected Differences of Endolymphatic Drainage System Between Vestibular Migraine and Unilateral Ménière's Disease.

Front Neurol 2022 29;13:814518. Epub 2022 Apr 29.

Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: We aimed to evaluate the diagnostic performance of some anatomical variables with regard to endolymphatic sac (ES) and duct (ED), measured by non-contrast three-dimensional sampling perfection with application-optimized contrasts using different flip angle evolutions (3D-SPACE) magnetic resonance imaging (MRI), in differentiating vestibular migraine (VM) from unilateral Ménière's disease (MD).

Methods: In this study, 81 patients with VM, 97 patients with unilateral MD, and 50 control subjects were enrolled. The MRI-visualized parameters, such as the distance between the vertical part of the posterior semicircular canal and the posterior fossa (MRI-PP distance) and visibility of vestibular aqueduct (MRI-VA), were measured bilaterally. Read More

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Efficiency of a novel middle ear pressure device for intractable definite Meniere's disease and delayed endolymphatic hydrops after certification by the public health insurance system in Japan.

Acta Otolaryngol 2022 May 11;142(5):388-394. Epub 2022 May 11.

Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.

Background: Middle ear pressure therapy (MEPT) is effective in treating intractable vertigo in patients with definite Meniere's disease (MD) and delayed endolymphatic hydrops (DEH) refractory to conservative treatment. A novel middle ear pressure device, the EFET01, which requires no transtympanic ventilation tubes, was developed in Japan, approved by the Japanese Ministry of Health, Labour and Welfare, and has been used under Japanese national health insurance since September 2018.

Objectives: To examine short-term therapeutic effect of MEPT using the ETET01 compared with previous clinical trial results. Read More

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Discrepancies in the caloric testing and video Head Impulse Test results in a case with bilateral lateral semicircular canal malformations.

Auris Nasus Larynx 2022 Apr 22. Epub 2022 Apr 22.

Department of Otolaryngology-Head & Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Lateral semicircular canal (LSCC) malformations represent one of the most common types of inner ear malformation. As many cases of LSCC malformations are asymptomatic, detailed vestibular functions in such cases remain unclear. We present a case with bilateral LSCC malformations for whom the function of each vestibular organ was evaluated by caloric testing, video Head Impulse Test (vHIT) and vestibular evoked myogenic potentials (VEMP). Read More

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A Perspective for Ménière's Disease: In Silico Investigations of Dexamethasone as a Direct Modulator of AQP2.

Biomolecules 2022 03 28;12(4). Epub 2022 Mar 28.

Structural Motility, Institut Curie, Paris Université Sciences et Lettres, Sorbonne Université, CNRS UMR144, F-75005 Paris, France.

Ménière's disease is a chronic illness characterized by intermittent episodes of vertigo associated with fluctuating sensorineural hearing loss, tinnitus and aural pressure. This pathology strongly correlates with a dilatation of the fluid compartment of the endolymph, so-called hydrops. Dexamethasone is one of the therapeutic approaches recommended when conventional antivertigo treatments have failed. Read More

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The value of vestibular evoked myogenic potential and electrocochleography in unexplained aural fullness.

Acta Otolaryngol 2022 Mar-Apr;142(3-4):225-228. Epub 2022 Apr 21.

Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Background: Unexplained aural fullness, after excluding external or middle ear diseases and vertigo, is not easily diagnosed.

Aim: The aim of this study is to determine the vestibular evoked myogenic potential (VEMP) and electrocochleography (ECochG) abnormal rates in patients with unexplained aural fullness, and analyzed the relationship between unexplained aural fullness and endolymphatic hydrops (EH).

Material And Methods: The VEMP and EcochG abnormal rates in 54 patients with unexplained aural fullness and 21 healthy volunteers, and the VEMP and EcochG abnormal rates in the four hearing loss groups were compared. Read More

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Expression of circadian clock genes in leukocytes of patients with Meniere's disease.

Laryngoscope Investig Otolaryngol 2022 Apr 18;7(2):584-591. Epub 2022 Feb 18.

Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan.

Objectives: The underlying etiology of Meniere's disease (MD) is not completely clear, but the precipitated triggers may alter the circadian clock in patients with MD. This study aims to survey the expression of circadian clock genes in peripheral blood (PB) leukocytes of MD patients.

Methods: We investigated the expression of nine circadian clock genes in the PB leukocytes of patients with MD and normal controls using real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Read More

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The Effect of Collagen Viscoelastoplasiticty on Reissner's Membrane Displacement: A Graphic Analysis.

Daniel J Pender

J Int Adv Otol 2022 Mar;18(2):96-99

Department of Otolaryngology, Columbia University, New York City, USA.

Background: The aim of this study is to analyze the effect of collagen viscoelastoplasticity on the bulge displacement of Reissner's membrane that is observed in endolymphatic hydrops and Meniere's disease.

Methods: Viscoelastoplastic load-deformation characteristics for Reissner's membrane were based on a reported collagen polymer model of the cochleo-saccular membranes. The projected bulge displacements of Reissner's model membrane at key distention points were quantified trigonometrically and plotted graphically. Read More

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[Vertigo attacks plus ear sounds: What disease is behind it?]

Frank Schmäl

MMW Fortschr Med 2022 04;164(7):24-25

Maria.Josef-Hospital, Zentrum für HNO, Lindenstraße 7, 48268, Greven, Germany.

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Association Between Meniere Disease and Migraine.

JAMA Otolaryngol Head Neck Surg 2022 05;148(5):457-464

Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Korea.

Importance: A connection between Meniere disease (MD) and migraine has been proposed, but the temporal association remains unknown.

Objective: To examine the bidirectional association of MD with migraine.

Design, Setting, And Participants: This case-control study included participants 40 years or older from the Korean National Health Insurance Service Health Screening Cohort from 2002 to 2015. Read More

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Relationship Between the Onset of Ménière's Disease and Sympathetic Hyperactivity.

Front Neurol 2022 17;13:804777. Epub 2022 Mar 17.

Department of Otorhinolaryngology, St. Marianna University School of Medicine, Kanagawa, Japan.

Objective: The pathogenesis of Ménière's disease is still largely unknown; however, it is known to be strongly associated with stress. Excessive stress can cause hyperactivity of the sympathetic autonomic nervous system. With the aim of understanding changes in sympathetic hyperactivity before and after Ménière's disease, we compared autonomic nervous function in patients in a stable phase of Ménière's disease and that in healthy adults. Read More

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Low-Dose Intratympanic Gentamicin for Unilateral Ménière's Disease: Accuracy of Early Vestibulo-Ocular Reflex Gain Reduction in Predicting Long-Term Clinical Outcome.

Front Neurol 2022 18;13:808570. Epub 2022 Mar 18.

Department of Otorhinolaryngology, Clínica Universidad de Navarra, Pamplona, Spain.

Background: The number of intratympanic gentamicin (ITG) injections needed to achieve vertigo control in patients with intractable Ménière's disease (MD) may vary from a single dose to several instillations. Changes in different vestibular test results have been used to define an endpoint of treatment, including the decrease of the vestibulo-ocular reflex (VOR) gain elicited by the head-impulse test.

Objective: To assess the accuracy of the VOR gain reduction after horizontal canal stimulation, as measured with the video head-impulse test (vHIT) 1 month after the first intratympanic injection, in predicting the need for one or more instillations to control vertigo spells in the long term. Read More

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Efficacy of Resection of Lateral Wall of Endolymphatic Sac for Treatment of Meniere's Disease.

Front Neurol 2022 11;13:827462. Epub 2022 Mar 11.

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Background: To explore the long-term efficacy and safety of resection of the lateral wall of the endolymphatic sac for the treatment of intractable Meniere's disease (MD) as an alternative surgical procedure for treating this disorder.

Methods: Data from 73 patients who were referred to our hospital and diagnosed with unilateral MD between January 2015 and June 2019 were retrospectively analyzed in this study. Seventy-three patients who had frequent vertigo even after receiving standardized conservative treatment for at least half a year underwent resection of the lateral wall of the endolymphatic sac. Read More

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[Dynamic changes of vestibular autorotation test in patients with unilateral vestibular dysfunction during rehabilitation].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Mar;57(3):270-275

Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

To explore the dynamic changes of vestibular autorotation test (VAT) before and after vestibular rehabilitation treatment in patients with unilateral vestibular hypofunction (UVH). A retrospective study was carried out,48 patients who were diagnosed with UVH and under vestibular rehabilitation in department of otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, from January 2019 to January 2021 were enrolled. Among them, there were 21 males and 27 females, with an average age of 46. Read More

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Intratympanic gentamicin compared with placebo for Ménière's disease.

Medwave 2022 Mar 22;22(2):e8696. Epub 2022 Mar 22.

Proyecto Epistemonikos, Santiago, Chile; Departamento de Otorrinolaringología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Introduction: Ménière's disease is a multifactorial disorder affecting the inner ear, characterized by episodes of spontaneous and recurrent vertigo, fluctuating hearing loss and tinnitus. Intratympanic gentamicin therapy has been used to reduce the intensity and frequency of attacks in intractable Ménière's disease, but it is associated with hearing loss. There is controversy regarding its efficacy and safety. Read More

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NaCl exposure results in increased expression and processing of IL-1β in Meniere's disease patients.

Sci Rep 2022 03 23;12(1):4957. Epub 2022 Mar 23.

The Feinstein Institutes for Medical Research, Manhasset, NY, USA.

Meniere's disease (MD) is a chronic disease that causes episodic vertigo, fluctuating hearing loss, and aural fullness, initially managed by dietary salt reduction, and use of diuretics. Our prior research in autoimmune inner ear disease (AIED) demonstrated that in peripheral blood mononuclear cell (PBMC) from corticosteroid-resistant AIED patients, increased production, processing and release of interleukin-1β (IL-1β) is observed and hearing could be improved with use of anakinra, an interleukin-1 receptor antagonist. We have further identified that in these AIED patients, IL-1β is uniquely processed to a 28 kDa pro-inflammatory product by caspase-7. Read More

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Benign Recurrent Vertigo: The Course of Vertigo Attacks Compared to Patients With Menière's Disease and Vestibular Migraine.

Front Neurol 2022 2;13:817812. Epub 2022 Mar 2.

Apeldoorn Dizziness Center, Gelre Hospitals, Apeldoorn, Netherlands.

Objective: To explore the course of vertigo attacks in patients with benign recurrent vertigo (BRV) as compared to patients with Menière's disease (MD) and vestibular migraine (VM).

Study Design: Prospective cohort study.

Setting: Tertiary referral center. Read More

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Vestibular migraine, demographic and clinical features of 415 patients: A multicenter study.

Clin Neurol Neurosurg 2022 04 8;215:107201. Epub 2022 Mar 8.

University of Health Sciences Izmir Tepecik Education and Research Hospital Department of Neurology, Izmir 35110, Turkey. Electronic address:

Objective: To evaluate demographic and clinical features of vestibular migraine (VM) patients METHODS: Four hundred fifteen patients with VM were evaluated by using a structured questionnaire in addition to clinical examination.

Results: The mean age of headache and vertigo onset was 25 years and 39 years, respectively. In 12. Read More

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Clinical application of MIIRMR as a salvage method in gadolinium-enhanced MRI after intra-tympanic injection.

Acta Otolaryngol 2022 Mar-Apr;142(3-4):241-247. Epub 2022 Mar 18.

Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Background: Three-dimensional fluid-attenuated inversion-recovery (3 D-FLAIR) and real inversion-recovery (3 D-real IR) sequences are used to detect endolymphatic hydrops (EH), but medium inversion-time inversion-recovery imaging with magnitude reconstruction (MIIRMR) may be more sensitive.

Aims: We investigated the inner-ear visualisation success rate and EH detection rates of 3 D-FLAIR and 3 D-real IR, and whether salvage MIIRMR could improve EH detection.

Materials And Methods: Fifty-one patients (102 ears) with episodic or chronic vestibular syndrome were injected intra-tympanically with 8-fold diluted gadolinium, and 3 D-FLAIR and 3 D-real IR images obtained 24-h post-injection. Read More

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