288,847 results match your criteria Memory Hove England[Journal]


Behavioral and Biochemical Features of the Course and Surgical Treatment of Experimental Obstructive Hydrocephalus in Young Rats.

Dev Neurosci 2019 Apr 18:1-10. Epub 2019 Apr 18.

Division of Pediatric Neurosurgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Introduction: Hydrocephalus is a multifactorial disease, affecting the dynamics of cerebrospinal fluid (CSF) and leading to severe neurological impairment in children; in spite of the recent advances in hydrocephalus research, it has many physiopathological aspects that still remain poorly understood, especially after treatment.

Objectives: To analyze the clinical, radiological, histopathological, and biochemical aspects of kaolin-induced hydrocephalus in an experimental model, both in the acute phase and after shunt treatment, by means of behavioral tests, magnetic resonance imaging (MRI) scans, histopathological studies, and level of inflammatory interleukins in the CSF.

Methods: Seven-day-old Wistar rats were used and subdivided into three subgroups: treated hydrocephalic (n = 24), untreated hydrocephalic (n = 17), and controls (n = 5). Read More

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http://dx.doi.org/10.1159/000497433DOI Listing

Effects of the Narrative Intervention Program for Preschool Portuguese Children.

Folia Phoniatr Logop 2019 Apr 18:1-7. Epub 2019 Apr 18.

CINTESIS.UA - Center for Health Technology and Services Research (UID/IC/04255/2013) and School of Health Sciences (ESSUA), University of Aveiro, Aveiro, Portugal,

Objective: This article analyzes the contribution of a narrative intervention program in linguistic performance (measured by the percentage of correct consonants [PCC], mean length of utterance [MLU], and auditory memory [AM]) of children.

Patients And Methods: A group of 14 children with primary language impairments participated in this study. The children were divided into two groups (seven children in each): the narrative intervention group (experimental group) and the control group. Read More

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http://dx.doi.org/10.1159/000496793DOI Listing

Meningioma and psychiatric symptoms: An individual patient data analysis.

Asian J Psychiatr 2019 Mar 28;42:94-103. Epub 2019 Mar 28.

Department of Psychiatry, Dr Ram Manohar Lohia Hospital PGIMER, New Delhi, India.

Meningioma is a slow-growing benign tumor arising from meninges and is usually asymptomatic. Though neuropsychiatric symptoms are common in patients with brain tumors, they often can be the only manifestation in cases of meningioma. Meningiomas might present with mood symptoms, psychosis, memory disturbances, personality changes, anxiety, or anorexia nervosa. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18762018183113
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http://dx.doi.org/10.1016/j.ajp.2019.03.029DOI Listing
March 2019
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Neural correlates of cognitive dysfunction in fibromyalgia patients: Reduced brain electrical activity during the execution of a cognitive control task.

Neuroimage Clin 2019 Apr 8;23:101817. Epub 2019 Apr 8.

Departamento de Psicoloxía Clínica e Psicobioloxía, Facultade de Psicoloxía, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.

Objectives: Fibromyalgia (FM) is a generalized chronic pain syndrome of unknown aetiology. Although FM patients frequently complain of cognitive dysfunction, this is one of the least studied symptoms. Research on brain activity associated with the perceived cognitive impairment is particularly scarce. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101817DOI Listing

Dopamine induces release of calcium from internal stores in layer II lateral entorhinal cortex fan cells.

Cell Calcium 2019 Apr 10;80:103-111. Epub 2019 Apr 10.

Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, Québec, H4B 1R6, Canada. Electronic address:

The entorhinal cortex plays an important role in temporal lobe processes including learning and memory, object recognition, and contextual information processing. The alteration of the strength of synaptic inputs to the lateral entorhinal cortex may therefore contribute substantially to sensory and mnemonic functions. The neuromodulatory transmitter dopamine exerts powerful effects on excitatory glutamatergic synaptic transmission in the entorhinal cortex. Read More

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http://dx.doi.org/10.1016/j.ceca.2019.04.003DOI Listing

Refining memory assessment of elderly people with cognitive impairment: Insights from the short-term memory binding test.

Arch Gerontol Geriatr 2019 Apr 1;83:114-120. Epub 2019 Apr 1.

Department of Basic Psychology II (Cognitive Processes), Faculty of Psychology, Complutense University of Madrid, Spain.

Alzheimer's disease (AD) affects temporary memory for bound features more remarkably than for individual features. Such selective impairments manifest from presymptomatic through dementia stages via titration procedures. A recent study suggested that without titration and with high memory load the binding selectivity may disappear in people at risk of AD such as those with Mild Cognitive Impairment (MCI). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01674943193008
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http://dx.doi.org/10.1016/j.archger.2019.03.025DOI Listing
April 2019
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Does mindfulness training help working memory 'work' better?

Curr Opin Psychol 2019 Mar 6;28:273-278. Epub 2019 Mar 6.

School of Law, University of Miami, FL, USA.

There has been a proliferation of mindfulness training (MT) programs offered across a multitude of settings, including military, business, sports, education, and medicine. As such, ascertaining training effectiveness and determining best practices for program delivery are of the utmost importance. MT is often introduced to promote an array of desired effects from better mood, better leadership and management skills, to improved workplace or academic performance. Read More

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http://dx.doi.org/10.1016/j.copsyc.2019.02.012DOI Listing

Late-Life Environmental Enrichment Preserves Short-Term Memory and May Attenuate Microglia in Male APP/PS1 Mice.

Neuroscience 2019 Apr 15. Epub 2019 Apr 15.

Wicking Dementia Research and Education Centre, Faculty of Health, University of Tasmania, Tasmania, 7000, Australia.

Environmental enrichment (EE) has been consistently reported to enhance cognitive function in mouse models of neuropathology. Microglia, implicated in Alzheimer's disease pathology, may mediate this effect. The aim of the present study was to investigate the effect of EE on cognitive function and microglia in mouse models of ageing and amyloidosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064522193025
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http://dx.doi.org/10.1016/j.neuroscience.2019.04.015DOI Listing
April 2019
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Pathophysiological Role of TRPM2 in Age-Related Cognitive Impairment in Mice.

Neuroscience 2019 Apr 15. Epub 2019 Apr 15.

Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.

Aging causes various functional changes, including cognitive impairment and inflammatory responses in the brain. Transient receptor potential melastatin 2 (TRPM2), a Ca-permeable channel expressed abundantly in immune cells, exacerbates inflammatory responses. Previously, we reported that TRPM2 on resident microglia plays a critical role in exacerbating inflammation, white matter injury, and cognitive impairment during chronic cerebral hypoperfusion; however, the physiological or pathophysiological role of TRPM2 during age-associated inflammatory responses remains unclear. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.04.012DOI Listing

The effect of blueberry interventions on cognitive performance and mood: a systematic review of randomized controlled trials.

Brain Behav Immun 2019 Apr 15. Epub 2019 Apr 15.

IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Victoria, 3216, Australia. Electronic address:

Blueberries are rich in polyphenols that may be beneficial to cognitive performance and mood. The aim of this systematic review was to evaluate randomized controlled trials investigating the effects of blueberries and blueberry products on measures of cognition and mood. In total, eleven articles (that included 12 studies) were identified using freeze-dried blueberries (n=9 studies), whole blueberries (n=2) and blueberry concentrate (n=1). Read More

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http://dx.doi.org/10.1016/j.bbi.2019.04.001DOI Listing

Sex-Specific Neurogenic Deficits and Neurocognitive Disorders in Middle-Aged HIV-1 Tg26 Transgenic Mice.

Brain Behav Immun 2019 Apr 15. Epub 2019 Apr 15.

Center for Metabolic Disease Research, Temple University Lewis Katz School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140, United States; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140, United States. Electronic address:

Varying degrees of cognitive deficits affect over half of all HIV-1 infected patients. Because of antiretroviral treatment (ART) regimens, the HIV-1 patient population is increasing in age. Very few epidemiological studies have focused on sex-specific differences in HIV-1-associated neurocognitive disorders (HAND). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08891591183060
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http://dx.doi.org/10.1016/j.bbi.2019.04.029DOI Listing
April 2019
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Physical activity sustains memory retrieval in dopamine-depleted mice previously treated with L-Dopa.

Behav Brain Res 2019 Apr 15:111915. Epub 2019 Apr 15.

Department of Neurology, Charité-Universitätsmedizin, Charitéplatz 1, 10117, Berlin, Germany. Electronic address:

The neurodegenerative disorder Parkinson's disease affects motor abilities as well as cognition. The gold standard therapy is L-Dopa, which mainly restores motor skills. Therefore, we require additional interventions to sustain cognitive functions in Parkinson's disease. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.111915DOI Listing

The ELAV family of RNA-binding proteins in synaptic plasticity and long-term memory.

Neurobiol Learn Mem 2019 Apr 15. Epub 2019 Apr 15.

Center for Neural Science, New York University, New York, NY 10003, USA. Electronic address:

The mechanisms of de novo gene expression and translation of specific gene transcripts have long been known to support long-lasting changes in synaptic plasticity and behavioral long-term memory. In recent years, it has become increasingly apparent that gene expression is heavily regulated not only on the level of transcription, but also through post-transcriptional gene regulation, which governs the subcellular localization, stability, and likelihood of translation of mRNAs. Specific families of RNA-binding proteins (RBPs) bind transcripts which contain AU-rich elements (AREs) within their 3' UTR and thereby govern their downstream fate. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10747427193007
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http://dx.doi.org/10.1016/j.nlm.2019.04.007DOI Listing
April 2019
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Benefit of wakeful resting on gist and peripheral memory retrieval in healthy younger and older adults.

Neurosci Lett 2019 Apr 15. Epub 2019 Apr 15.

Human Cognitive Neuroscience, Psychology, University of Edinburgh, Edinburgh, UK.

Retrieval is greater if new learning is followed by a period of wakeful rest, minimising the likelihood of retroactive interference. It is not known if this benefit extends to recollection of both gist and peripheral details, nor whether age affects the benefit of wakeful resting in either of these types of recollection. Forty-five younger and forty older adults were presented with prose passages for later recall followed by a period of either interference or wakeful resting. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.026DOI Listing

Epigenetic regulation of immediate-early gene Nr4a2/Nurr1 in the medial habenula during reinstatement of cocaine-associated behavior.

Neuropharmacology 2019 Apr 15. Epub 2019 Apr 15.

Department of Neurobiology and Behavior, School of Biological Sciences University of California, Irvine, USA; UC Irvine Center for Addiction Neuroscience, School of Biological Sciences, University of California, Irvine, USA; Center for the Neurobiology of Learning and Memory, School of Biological Sciences, University of California, Irvine, USA. Electronic address:

Propensity to relapse following long-periods of abstinence is a key feature of substance use disorder. Drugs of abuse, such as cocaine, cause long-term changes in the neural circuitry regulating reward, motivation, and memory processes through dysregulation of various molecular mechanisms, including epigenetic regulation of activity-dependent gene expression. Underlying drug-induced changes to neural circuit function are the molecular mechanisms regulating activity-dependent gene expression. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.04.016DOI Listing

Omega-3 fatty acids protects against chronic sleep-deprivation induced memory impairment.

Life Sci 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Aims: The current study aims to evaluate the possible protective effect of omega-3 fatty acids on memory impairment induced by sleep-deprivation in rats.

Materials And Methods: Animals were chronically sleep deprived using the modified multiple platform model (8 h/day for 8 weeks). Omega-3 fatty acids were administered as fish oil via oral gavage at a daily dose of 100 mg omega-3 PUFA/100 g BWT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193028
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http://dx.doi.org/10.1016/j.lfs.2019.04.028DOI Listing
April 2019
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Differential diagnosis between Alzheimer's disease and other dementias: Role of cerebrospinal fluid biomarkers.

Clin Biochem 2019 Apr 15. Epub 2019 Apr 15.

Centre for Memory Disturbances, Laboratory of Clinical Neurochemistry, Section of Neurology, Department of Medicine, University of Perugia, Perugia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2019.04.011DOI Listing

Wide sensory filters underlie performance in memory-based discrimination and generalization.

PLoS One 2019 18;14(4):e0214817. Epub 2019 Apr 18.

Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.

The way animals respond to a stimulus depends largely on an internal comparison between the current sensation and the memory of previous stimuli and outcomes. We know little about the accuracy with which the physical properties of the stimuli influence this type of memory-based discriminative decisions. Research has focused largely on discriminations between stimuli presented in quick succession, where animals can make relative inferences (same or different; higher or lower) from trial to trial. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214817PLOS
April 2019
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Varicose veins of lower extremities: Insights from the first large-scale genetic study.

PLoS Genet 2019 Apr 18;15(4):e1008110. Epub 2019 Apr 18.

Laboratory of Theoretical and Applied Functional Genomics, Novosibirsk State University, Novosibirsk, Russia.

Varicose veins of lower extremities (VVs) are a common multifactorial vascular disease. Genetic factors underlying VVs development remain largely unknown. Here we report the first large-scale study of VVs performed on a freely available genetic data of 408,455 European-ancestry individuals. Read More

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http://dx.doi.org/10.1371/journal.pgen.1008110DOI Listing

Understanding Variability in Individual Response to Hearing Aid Signal Processing in Wearable Hearing Aids.

Ear Hear 2019 Apr 10. Epub 2019 Apr 10.

Department of Preventive Medicine, Biostatistics Collaboration Center, Feinberg School of Medicine, Northwestern University.

Objectives: Previous work has suggested that individual characteristics, including amount of hearing loss, age, and working memory ability, may affect response to hearing aid signal processing. The present study aims to extend work using metrics to quantify cumulative signal modifications under simulated conditions to real hearing aids worn in everyday listening environments. Specifically, the goal was to determine whether individual factors such as working memory, age, and degree of hearing loss play a role in explaining how listeners respond to signal modifications caused by signal processing in real hearing aids, worn in the listener's everyday environment, over a period of time. Read More

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http://dx.doi.org/10.1097/AUD.0000000000000717DOI Listing

Leveraging a Big Dataset to Develop a Recurrent Neural Network to Predict Adverse Glycemic Events in Type 1 Diabetes.

IEEE J Biomed Health Inform 2019 Apr 17. Epub 2019 Apr 17.

Patients with type 1 diabetes (T1D) do not produce their own insulin. They must continuously monitor their glucose and make decisions about insulin dosing to avoid the consequences of adverse glucose excursions. Continuous glucose monitoring (CGM) systems and insulin pumps are state-of-the-art systems that can help people with T1D manage their glucose. Read More

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http://dx.doi.org/10.1109/JBHI.2019.2911701DOI Listing

Deep Robust Framework for Protein Function Prediction using Variable-Length Protein Sequences.

IEEE/ACM Trans Comput Biol Bioinform 2019 Apr 16. Epub 2019 Apr 16.

The order of amino acids in a protein sequence enables the protein to acquire a conformation suitable for performing functions, thereby motivating the need to analyse these sequences for predicting functions. Although machine learning based approaches are fast compared to methods using BLAST, FASTA, etc., they fail to perform well for long protein sequences (with more than 300 amino acids). Read More

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https://ieeexplore.ieee.org/document/8692646/
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http://dx.doi.org/10.1109/TCBB.2019.2911609DOI Listing
April 2019
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Design of Bistable Gold@Spin-Crossover Core-Shell Nanoparticles Showing Large Electrical Responses for the Spin Switching.

Adv Mater 2019 Apr 18:e1900039. Epub 2019 Apr 18.

Instituto de Ciencia Molecular (ICMol), Universidad de Valencia, c/Catedrático José Beltrán 2, Paterna, 46980, Spain.

A simple chemical protocol to prepare core-shell gold@spin-crossover (Au@SCO) nanoparticles (NPs) based on the 1D spin-crossover [Fe(Htrz) (trz)](BF ) coordination polymer is reported. The synthesis relies on a two-step approach consisting of a partial surface ligand substitution of the citrate-stabilized Au NPs followed by the controlled growth of a very thin layer of the SCO polymer. As a result, colloidally stable core@shell spherical NPs with a Au core of ca. Read More

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http://dx.doi.org/10.1002/adma.201900039DOI Listing

Forgetting as the friend of learning: implications for teaching and self-regulated learning.

Adv Physiol Educ 2019 Jun;43(2):164-167

Department of Psychology, University of California , Los Angeles.

One of the "important peculiarities" of human learning (Bjork RA and Bjork EL. , 1992, p. 35-67) is that certain conditions that produce forgetting-that is, impair access to some to-be-learned information studied earlier-also enhance the learning of that information when it is restudied. Read More

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http://dx.doi.org/10.1152/advan.00001.2019DOI Listing

Visual memory profile in children with high functioning autism.

Appl Neuropsychol Child 2019 Apr 18:1-11. Epub 2019 Apr 18.

a Department of Education , University of Genoa , Genoa , Italy.

Visual memory in children with high-functioning autism (HFA) is an area of debate. According to the few studies that have examined visual memory in children with autism, the memory profile appears to vary according to the memory process and type of stimuli, and contrasting results may be found. This study aims to analyze the visual memory profile of children with HFA. Read More

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http://dx.doi.org/10.1080/21622965.2019.1594231DOI Listing

Evidence against preserved syntactic comprehension in healthy aging.

J Exp Psychol Learn Mem Cogn 2019 Apr 18. Epub 2019 Apr 18.

School of Psychology.

We investigated age-related differences in syntactic comprehension in young and older adults. Most previous research found no evidence of age-related decline in syntactic processing. We investigated elementary syntactic comprehension of minimal sentences (e. Read More

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http://dx.doi.org/10.1037/xlm0000707DOI Listing

Retrieval practice enhances near but not far transfer of spatial memory.

J Exp Psychol Learn Mem Cogn 2019 Apr 18. Epub 2019 Apr 18.

Center for Applied Brain and Cognitive Sciences.

Students learn more effectively through repeated retrieval of study materials relative to repeated exposure to the materials, a phenomenon known as the testing effect or retrieval practice. This pattern has been demonstrated repeatedly with verbal materials, and more recently with visuospatial materials. The extent to which retrieval practice produces spatial memories that successfully transfer to more diverse task demands remains unknown. Read More

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http://dx.doi.org/10.1037/xlm0000710DOI Listing

Working memory capacity and sustained attention: A cognitive-energetic perspective.

J Exp Psychol Learn Mem Cogn 2019 Apr 18. Epub 2019 Apr 18.

Department of Psychology.

A cognitive-energetic account of individual differences in working memory capacity (WMC) and sustained attention performance is proposed suggesting that variation in the voluntary control of the intensity of attention (intrinsic alertness) is critical for the relation between WMC and attention control. Four experiments examining individual differences were conducted to test this account. The results suggested that WMC was consistently related to the slowest reaction times in conditions where the interstimulus interval (ISI) was varied or was fixed at a long interval. Read More

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http://dx.doi.org/10.1037/xlm0000712DOI Listing

Grab that face, hammer, or line: No effect of hands position on visual memory.

J Exp Psychol Hum Percept Perform 2019 Apr 18. Epub 2019 Apr 18.

Department of Education and Psychology.

Is visual memory enhanced near the hands? The embodied cognition framework postulates that body states and action greatly influence cognition. Accordingly, numerous studies have argued that hands position affects visual perception and attention. However, it is less clear whether this effect could be extended to visual memory. Read More

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http://dx.doi.org/10.1037/xhp0000649DOI Listing

Immediate and long-term efficacy of executive functions cognitive training in older adults: A systematic review and meta-analysis.

Psychol Bull 2019 Apr 18. Epub 2019 Apr 18.

School of Applied Psychology, Griffith University.

There has been growing interest in enhancing cognition in older adulthood via computerized cognitive training (CCT), though, there is controversy surrounding the efficacy of CCT in promoting improvements to functional everyday activities. As core executive-functions (EFs)-cognitive-flexibility, inhibition, working memory-are applicable to most aspects of daily living, CCT targeting these processes would likely promote gains on trained tasks, and potentially on similar untrained tasks (near-transfer), and general cognitive performance (far-transfer). We report two meta-analyses investigating the immediate (pretest to posttest) and long-term efficacy (pretest to follow-up) of core-EF CCT in improving cognition among older adults. Read More

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http://dx.doi.org/10.1037/bul0000196DOI Listing

Using response time distributions and race models to characterize primacy and recency effects in free recall initiation.

Psychol Rev 2019 Apr 18. Epub 2019 Apr 18.

School of Psychological Science.

Primacy and recency effects are common benchmarks for models of free recall and episodic memory. In this work, we show that RT distributions carry diagnostic information about how items enter into competition for recall, and how that competition impacts on the dynamics of recall and leads to novel conclusions about the forms of primacy and recency effects. We jointly fit RT distributions and serial position functions for free recall initiation with both a racing diffusion model and the linear ballistic accumulator (LBA: Brown & Heathcote, 2008). Read More

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http://dx.doi.org/10.1037/rev0000149DOI Listing

Police lineups of the future?

Am Psychol 2019 Apr 18. Epub 2019 Apr 18.

School of Psychology.

Problems associated with eyewitness identification decisions have long been highlighted by memory researchers (e.g., Loftus, 1979), with overwhelming evidence that witnesses can err, sometimes with disastrous consequences. Read More

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http://dx.doi.org/10.1037/amp0000465DOI Listing

Cognitive load associations when utilizing auditory display within image-guided neurosurgery.

Int J Comput Assist Radiol Surg 2019 Apr 17. Epub 2019 Apr 17.

Gina Cody School of Engineering and Computer Science, Concordia University, EV 3.301, 1455 De Maisonneuve Blvd. W., Montreal, QC, H3G 1M8, Canada.

Purpose: The combination of data visualization and auditory display (e.g., sonification) has been shown to increase accuracy, and reduce perceived difficulty, within 3D navigation tasks. Read More

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http://link.springer.com/10.1007/s11548-019-01970-w
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http://dx.doi.org/10.1007/s11548-019-01970-wDOI Listing
April 2019
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Improved neuropsychological outcomes following proton therapy relative to x-ray therapy for pediatric brain tumor patients.

Neuro Oncol 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago IL.

Background: Survivors of pediatric brain tumors are at risk for impaired development in multiple neuropsychological domains. The purpose of this study was to compare neuropsychological outcomes of pediatric brain tumor patients who underwent x-ray radiotherapy (XRT) versus proton radiotherapy (PRT).

Methods: Pediatric patients who underwent either XRT or PRT and received post-treatment age-appropriate neuropsychological evaluation including measures of intelligence (IQ), attention, memory, visuographic skills, academic skills, and parent-reported adaptive functioning were identified. Read More

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http://dx.doi.org/10.1093/neuonc/noz070DOI Listing

Enhanced discriminative aversive learning and amygdala responsivity in 5-HT transporter mutant mice.

Transl Psychiatry 2019 Apr 17;9(1):139. Epub 2019 Apr 17.

Department of Experimental Psychology, University of Oxford, Oxford, UK.

Genetic variation in the human serotonin transporter (5-HTT) has been linked to altered fear learning but the data are inconsistent and the mechanism is unclear. The present study investigated conditioned aversive learning in 5-HTT knockout (KO) mice while simultaneously recording neural network activity (theta oscillations) and hemodynamic responses (tissue oxygen delivery) from the amygdala, a brain region necessary for forming fearful memories. Conditioned aversive learning was measured using a discrimination learning task in which one auditory cue was paired with foot-shock, whereas a second auditory cue was not. Read More

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http://dx.doi.org/10.1038/s41398-019-0476-8DOI Listing

Human antibody response to Zika targets type-specific quaternary structure epitopes.

JCI Insight 2019 Apr 18;4(8). Epub 2019 Apr 18.

Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

The recent Zika virus (ZIKV) epidemic in the Americas has revealed rare but serious manifestations of infection. ZIKV has emerged in regions endemic for dengue virus (DENV), a closely related mosquito-borne flavivirus. Cross-reactive antibodies confound studies of ZIKV epidemiology and pathogenesis. Read More

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http://dx.doi.org/10.1172/jci.insight.124588DOI Listing

Phenotypic and functional differences between HHV-6 and HCMV specific T-cells.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

INSERM 1135, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Sorbonne Université, F-75013, Paris, France

: Human herpesvirus 6 (HHV-6) infects over 90% of the population, and establishes a latent infection, with asymptomatic episodes of reactivation. However, HHV-6 reactivation is associated with morbidity and sometimes mortality in immunocompromised patients. To date, the control of the virus in healthy virus carriers and its failure in patients with disease remain poorly understood. Read More

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http://dx.doi.org/10.1128/JVI.02321-18DOI Listing

Temperature-responsive biometamaterials for gastrointestinal applications.

Sci Transl Med 2019 Apr;11(488)

Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

We hypothesized that ingested warm fluids could act as triggers for biomedical devices. We investigated heat dissipation throughout the upper gastrointestinal (GI) tract by administering warm (55°C) water to pigs and identified two zones in which thermal actuation could be applied: esophageal (actuation through warm water ingestion) and extra-esophageal (protected from ingestion of warm liquids and actuatable by endoscopically administered warm fluids). Inspired by a blooming flower, we developed a capsule-sized esophageal system that deploys using elastomeric elements and then recovers its original shape in response to thermal triggering of shape-memory nitinol springs by ingestion of warm water. Read More

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http://dx.doi.org/10.1126/scitranslmed.aau8581DOI Listing

Network-targeted stimulation engages neurobehavioral hallmarks of age-related memory decline.

Neurology 2019 Apr 17. Epub 2019 Apr 17.

From the Departments of Medical Social Sciences (A.S.N., E.L.K., J.L.V.), Ken and Ruth Davee Department of Neurology (M.-M.M., S.V., J.L.V.), and Psychiatry and Behavioral Sciences (S.W., J.L.V.), Cognitive Neurology and Alzheimer's Disease Center (A.S.N., M.-M.M., S.W.), Feinberg School of Medicine, Northwestern University, Chicago, IL.

Objective: To test whether targeting hippocampal-cortical brain networks with high-frequency transcranial magnetic stimulation in older adults influences behavioral and neural measures characteristic of age-related memory impairment.

Methods: Fifteen adults aged 64 to 80 years (mean = 72 years) completed a single-blind, sham-controlled experiment. Stimulation targets in parietal cortex were determined based on fMRI connectivity with the hippocampus. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007502DOI Listing
April 2019
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A Review of the Role of Auditory Evoked Potentials in Mild Traumatic Brain Injury Assessment.

Trends Hear 2019 Jan-Dec;23:2331216519840094

3 Department of Communication Sciences and Disorders, University of North Carolina at Greensboro, NC, USA.

Around 75% to 90% of people who experience a traumatic brain injury (TBI) are classified as having a mild TBI (mTBI). The term mTBI is synonymous with concussion or mild head injury (MHI) and is characterized by symptoms of headache, nausea, dizziness, and blurred vision. Problems in cognitive abilities such as deficits in memory, processing speed, executive functioning, and attention are also considered symptoms of mTBI. Read More

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http://dx.doi.org/10.1177/2331216519840094DOI Listing

Exploring the science, safety, and benefits of air care products: perspectives from the inaugural air care summit.

Inhal Toxicol 2019 Apr 18:1-13. Epub 2019 Apr 18.

q Drug and Poison Information Center , Cincinnati Children's Hospital , Cincinnati , OH , USA.

Seventy-one percent of US households purchase air care products. Air care products span a diverse range of forms, including scented aerosol sprays, pump sprays, diffusers, gels, candles, and plug-ins. These products are used to eliminate indoor malodors and to provide pleasant scent experiences. Read More

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http://dx.doi.org/10.1080/08958378.2019.1597221DOI Listing

Effects of Helminth Eradication on the Immune System.

Pathog Immun 2017 10;2(2):293-307. Epub 2017 Jul 10.

Kaplan Medical Center, Ben-Ari Institute of Clinical Immunology and AIDS Center, Rehovot, Israel.

Introduction: Helminth infection has a profound effect on the immune system. However, the precise nature of the immune changes that are elicited by helminth infection have not been sufficiently characterized. Furthermore, the reversibility of these changes after treatment has not been documented sufficiently. Read More

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http://dx.doi.org/10.20411/pai.v2i2.205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423624PMC

Self-supervised learning of the biologically-inspired obstacle avoidance of hexapod walking robot.

Bioinspir Biomim 2019 Apr 17. Epub 2019 Apr 17.

dept. of Computer Science, Ceske Vysoke Uceni Technicke Fakulta elektrotechnicka, Prague, CZECH REPUBLIC.

In this paper, we propose an integrated biologically inspired visual collision avoidance approach that is deployed on a real hexapod walking robot. The proposed approach is based on the Lobula Giant Movement Detector (LGMD) that is a neural network for looming stimuli detection that can be found in visual pathways of insects, such as locusts. Although a superior performance of the LGMD in the detection of intercepting objects has been shown in many collision avoiding scenarios, its direct integration with motion control is an unexplored topic. Read More

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http://iopscience.iop.org/article/10.1088/1748-3190/ab1a9c
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http://dx.doi.org/10.1088/1748-3190/ab1a9cDOI Listing
April 2019
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Clinical, immunologic, and molecular spectrum of patients with LPS-responsive beige-like anchor protein (LRBA) deficiency: a systematic review.

J Allergy Clin Immunol Pract 2019 Apr 14. Epub 2019 Apr 14.

Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. Electronic address:

Background: LPS-responsive beige-like anchor protein (LRBA) deficiency is a primary immunodeficiency and immune dysregulation syndrome caused by biallelic mutations in the LRBA gene. These mutations usually abrogate the protein expression of LRBA, leading to a broad spectrum of clinical phenotypes including autoimmunity, chronic diarrhea, hypogammaglobulinemia and recurrent infections.

Objective: Our aim was to systematically collect all studies reporting on the clinical manifestations, molecular and laboratory findings, and management of patients with LRBA deficiency. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.04.011DOI Listing

Immune Signaling in Neurodegeneration.

Immunity 2019 Apr;50(4):955-974

Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA. Electronic address:

Neurodegenerative diseases of the central nervous system progressively rob patients of their memory, motor function, and ability to perform daily tasks. Advances in genetics and animal models are beginning to unearth an unexpected role of the immune system in disease onset and pathogenesis; however, the role of cytokines, growth factors, and other immune signaling pathways in disease pathogenesis is still being examined. Here we review recent genetic risk and genome-wide association studies and emerging mechanisms for three key immune pathways implicated in disease, the growth factor TGF-β, the complement cascade, and the extracellular receptor TREM2. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.03.016DOI Listing

Strength training and running elicit different neuroprotective outcomes in a β-amyloid peptide-mediated Alzheimer's disease model.

Physiol Behav 2019 Apr 14. Epub 2019 Apr 14.

Applied Neuromechanics Group, Federal University of Pampa, Uruguaiana, 97501-970, Brazil. Electronic address:

Aerobic exercise induces neuroprotection, but few studies investigated whether strength training has similar potential. Here we examine whether effects of strength training differ from those of running training concerning cognitive symptomatology, oxidative stress and cholinergic status in a model of AD-like cognitive impairment induced by intrahippocampal infusion of a mix of β-amyloid peptides (Aβ) in rats. Male Wistar rats were submitted to 8 weeks of running exercise (RunEx; 40 min sessions at 70% of indirect VO max, 3 times/week) or strength exercise (StrEx; 3 sessions/week, 12 repetitions in 8 sets, 2 sets with repetitions at 50%, 2 at 75%, 2 at 90% and 2 at 100% of the maximum load), followed by Aβ infusion in the dorsal hippocampus. Read More

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http://dx.doi.org/10.1016/j.physbeh.2019.04.012DOI Listing

Sex-specific differences in adult cognition and neuroplasticity following repeated combinatory stress and TrkB receptor antagonism in adolescence.

Horm Behav 2019 Apr 14. Epub 2019 Apr 14.

Behavioral Neuroscience Group, School of Psychology, University of Ottawa, 136 Jean-Jacques Lussier, Ottawa, ON, Canada. Electronic address:

Evidence supports brain-derived neurotrophic factor (BDNF) and its primary receptor tyrosine-related kinase B (TrkB) as targets in the treatment of mood disorders. This study characterized the impact of a 10-day combinatory stress paradigm (alternating days of restraint stress and forced swim) and administration of the selective TrkB antagonist ANA-12 (0.5 mg/kg, i. Read More

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http://dx.doi.org/10.1016/j.yhbeh.2019.04.006DOI Listing

Nobiletin Protects Against Systemic Inflammation-Stimulated Memory Impairment via MAPK and NF-κB Signaling Pathways.

J Agric Food Chem 2019 Apr 17. Epub 2019 Apr 17.

Neuroinflammation is intensively demonstrated to be related with various neurodegenerative diseases including Parkinson disease (PD), amyotrophic lateral sclerosis (ALS), and Alzheimer disease (AD). As a natural polymethoxylated flavone, Nobiletin (NOB) is reported to alleviate oxidative stress, insulin resistance, and obesity. In this study, we evaluated the protection effects of NOB on neuroinflammation and memory deficit. Read More

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http://dx.doi.org/10.1021/acs.jafc.9b00133DOI Listing

Scaling molecular dynamics beyond 100,000 processor cores for large-scale biophysical simulations.

J Comput Chem 2019 Apr 17. Epub 2019 Apr 17.

Los Alamos National Laboratory, Los Alamos, New Mexico.

The growing interest in the complexity of biological interactions is continuously driving the need to increase system size in biophysical simulations, requiring not only powerful and advanced hardware but adaptable software that can accommodate a large number of atoms interacting through complex forcefields. To address this, we developed and implemented strategies in the GENESIS molecular dynamics package designed for large numbers of processors. Long-range electrostatic interactions were parallelized by minimizing the number of processes involved in communication. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcc.25840
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http://dx.doi.org/10.1002/jcc.25840DOI Listing
April 2019
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Predicting Early Mild Cognitive Impairment With Free Recall: The Primacy of Primacy.

Arch Clin Neuropsychol 2019 Apr 17. Epub 2019 Apr 17.

School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, UK.

Objectives: Serial position effects have been found to discriminate between normal and pathological aging, and to predict conversion from Mild Cognitive Impairment (MCI) to Alzheimer's disease (AD). Different scoring methods have been used to estimate the accuracy of these predictions. In the current study, we investigated delayed primacy as predictor of progression to early MCI over established diagnostic memory methods. Read More

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https://academic.oup.com/acn/advance-article/doi/10.1093/arc
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http://dx.doi.org/10.1093/arclin/acz013DOI Listing
April 2019
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