285,877 results match your criteria Memory Hove England[Journal]


Treatment with the glutamate modulator riluzole prevents early life stress-induced cognitive deficits and impairments in synaptic plasticity in APPswe/PS1dE9 mice.

Neuropharmacology 2019 Feb 19. Epub 2019 Feb 19.

Brain Plasticity Group, SILS-CNS, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, the Netherlands. Electronic address:

Background: Environmental factors like stress affect age-related cognitive deficits and promote Alzheimer's disease (AD)-related pathology in mice. Excess glutamate has been proposed as a possible mediator underlying these effects in the hippocampus, a vulnerable brain region implicated in learning and memory.

Methods: Here, we examined a) whether stress applied during a sensitive developmental period early in life affects later synaptic plasticity, learning and memory and plaque load in the APPswe/PS1dE9 mouse model for Alzheimer's disease and b) whether these effects could be rescued using long-term treatment with the glutamate modulator riluzole. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.02.023DOI Listing
February 2019

CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury.

Cell 2019 Feb;176(5):1143-1157.e13

Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA. Electronic address:

We tested a newly described molecular memory system, CCR5 signaling, for its role in recovery after stroke and traumatic brain injury (TBI). CCR5 is uniquely expressed in cortical neurons after stroke. Post-stroke neuronal knockdown of CCR5 in pre-motor cortex leads to early recovery of motor control. Read More

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http://dx.doi.org/10.1016/j.cell.2019.01.044DOI Listing
February 2019

Absence of pathogenic mutations in CD59 in chronic inflammatory demyelinating polyradiculoneuropathy.

PLoS One 2019 22;14(2):e0212647. Epub 2019 Feb 22.

Neuromuscular Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Objective: Mutations in CD59 cause CIDP-like polyneuropathy in children with inherited chronic hemolysis. We hypothesized that mutations in CD59 might be found in a subset of sporadic CIDP patients.

Methods: 35 patients from two centers, fulfilling the EFNS/PNS diagnostic criteria for CIDP were included. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212647PLOS
February 2019

Aerosol vaccination with Bacille Calmette-Guerin induces a trained innate immune phenotype in calves.

PLoS One 2019 22;14(2):e0212751. Epub 2019 Feb 22.

Department of Veterinary Microbiology and Preventative Medicine, Iowa State University, Ames, Iowa, United States of America.

Mycobacterium bovis Bacillus Calmette-Guérin (BCG) is a live attenuated vaccine for use against tuberculosis (TB); however, it is known to reduce childhood mortality from infections other than TB. The unspecific protection induced by BCG vaccination has been associated with the induction of memory-like traits of the innate immune system identified as 'trained' immunity. In humans and mouse models, in vitro and in vivo BCG training leads to enhanced production of monocyte-derived proinflammatory cytokines in response to secondary unrelated bacterial and fungal pathogens. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212751PLOS
February 2019

Computational assessment of long-term memory structures from SDA-M related to action sequences.

PLoS One 2019 22;14(2):e0212414. Epub 2019 Feb 22.

CITEC - Center of Excellence "Cognitive Interaction Technology", Bielefeld University, Bielefeld, Germany.

Assistance systems should be able to adapt to individual task-related skills and knowledge. Structural-dimensional analysis of mental representations (SDA-M) is an established method for retrieving human memory structures related to specific activities. For this purpose, SDA-M involves a semi-automatized survey of users (the "split procedure"), which yields data about users' associations between action representations in long-term memory. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212414PLOS
February 2019

Cognitive functions and jugular venous reflux in severe mitral regurgitation: A pilot study.

PLoS One 2019 22;14(2):e0207832. Epub 2019 Feb 22.

School of Medicine, National Yang Ming University, Taipei, Taiwan.

Cardiac diseases with elevated central venous pressure have higher frequency of jugular venous reflux (JVR), which is associated with decreased cerebral blood flow and white matter hyperintensities. Whether patients with severe mitral-regurgitation (SMR) have poorer cognitive functions and whether JVR is involved were determined in this pilot study. Patients with SMR and age/sex-matched controls were prospectively recruited. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207832PLOS
February 2019

Effects of Stimulus Exploration Length and Time on the Integration of Information in Haptic Softness Discrimination.

IEEE Trans Haptics 2019 Feb 20. Epub 2019 Feb 20.

In haptic perception information is often sampled serially (e.g. a stimulus is repeatedly indented to estimate its softness), requiring that sensory information is retained and integrated over time. Read More

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http://dx.doi.org/10.1109/TOH.2019.2899298DOI Listing
February 2019

The Classification of Minor Gait Alterations Using Wearable Sensors and Deep Learning.

IEEE Trans Biomed Eng 2019 Feb 21. Epub 2019 Feb 21.

Objective: This paper describes how non-invasive wearable sensors can be used in combination with deep learn- ing to classify artificially induced gait alterations without the requirement for a medical professional or gait analyst to be present. This approach is motivated by the goal of diagnosing gait abnormalities on a symptom by symptom basis, irrespective of other neuromuscular movement disorders patients may be affected by. This could lead to improvements in treatment and offer a greater insight into movement disorders. Read More

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http://dx.doi.org/10.1109/TBME.2019.2900863DOI Listing
February 2019

Switching between persistent firing and depolarization block in individual rat CA1 pyramidal neurons.

Hippocampus 2019 Feb 22. Epub 2019 Feb 22.

Faculty of Psychology, Mercator Research Group - Structure of Memory, Ruhr University Bochum, Bochum, Germany.

The hippocampal formation plays a role in mnemonic tasks and epileptic discharges in vivo. In vitro, these functions and malfunctions may relate to persistent firing (PF) and depolarization block (DB), respectively. Pyramidal neurons of the CA1 field have previously been reported to engage in either PF or DB during cholinergic stimulation. Read More

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http://dx.doi.org/10.1002/hipo.23078DOI Listing
February 2019

The impact of pathological high-frequency oscillations on hippocampal network activity in rats with chronic epilepsy.

Elife 2019 Feb 22;8. Epub 2019 Feb 22.

Neurobiology Section and Center for Neural Circuits and Behavior, Division of Biological Sciences, University of California, San Diego, La Jolla, United States.

In epilepsy, brain networks generate pathological high-frequency oscillations (pHFOs) during interictal periods. To understand how pHFOs differ from normal oscillations in overlapping frequency bands and potentially perturb hippocampal processing, we performed high-density single unit and local field potential recordings from hippocampi of behaving rats with and without chronic epilepsy. In epileptic animals, we observed two types of co-occurring fast oscillations, which by comparison to control animals we could classify as 'ripple-like' or 'pHFO'. Read More

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http://dx.doi.org/10.7554/eLife.42148DOI Listing
February 2019

Obesity caused by a high-fat diet regulates the Sirt1/PGC-1α/FNDC5/BDNF pathway to exacerbate isoflurane-induced postoperative cognitive dysfunction in older mice.

Nutr Neurosci 2019 Feb 22:1-12. Epub 2019 Feb 22.

a Department of Anesthesia , Zhongshan Hospital, Fudan University , Shanghai , People's Republic of China.

Objectives: To investigate the effects of obesity caused by high-fat diet (HFD) on postoperative cognitive dysfunction (POCD) and expression of the Sirt1/PGC-1α/FNDC5/BDNF pathway in the hippocampus of older mice.

Methods: Fifty-six 15-month-old male C57BL/6 mice were randomly divided into eight groups - ad libitum control (ALC), ad libitum surgery (ALS), ad libitum surgery with PBS (ALS + PBS), ad libitum surgery with resveratrol (ALS + Res), HFD control (HFC), HFD surgery (HFS), HFD surgery with PBS (HFS + PBS), HFD surgery with resveratrol (HFS + Res). Surgery group mice were exposed to isoflurane before tibial fracture internal fixation. Read More

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http://dx.doi.org/10.1080/1028415X.2019.1581460DOI Listing
February 2019

Multielement Episodic Encoding in Young and Older Adults.

J Cogn Neurosci 2019 Feb 22:1-18. Epub 2019 Feb 22.

Georgia Institute of Technology.

Previous research on age-related associative memory deficits has generally focused on memory for single associations. However, our real-world experiences contain a multitude of details that must be effectively integrated and encoded into coherent representations to facilitate subsequent retrieval of the event as a whole. How aging interferes with the processes necessary for multielement encoding is still unknown. Read More

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http://dx.doi.org/10.1162/jocn_a_01384DOI Listing
February 2019

Visual statistical learning deficits in memory-impaired individuals.

Neurocase 2019 Feb 22:1-7. Epub 2019 Feb 22.

a Department of Psychology , University of Nevada , Reno , NV , USA.

Visual statistical learning (VSL) refers to the learning of environmental regularities. Classically considered an implicit process, one patient with isolated hippocampal damage is severely impaired at VSL tasks, suggesting involvement of explicit memory. Here, we asked whether memory impairment (MI) alone, absent of clear hippocampal pathology, predicted deficits across different VSL tasks. Read More

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http://dx.doi.org/10.1080/13554794.2019.1579843DOI Listing
February 2019

Performance validity measures in clinical patients with aphasia.

J Clin Exp Neuropsychol 2019 Feb 22:1-8. Epub 2019 Feb 22.

a Department of Neurology , Medical University of Innsbruck , Innsbruck , Austria.

Introduction: Performance validity testing has developed into an indispensible element of neuropsychological assessment, mostly applied in forensic determinations. Its aim is to distinguish genuine patient performance from invalid test profiles. Limits to the applicability of performance validity tests (PVTs) may arise when genuine cognitive symptoms are present. Read More

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http://dx.doi.org/10.1080/13803395.2019.1579783DOI Listing
February 2019

CAR T cells generated using Sleeping Beauty transposon vectors and expanded with an EBV-transformed lymphoblastoid cell line (LCL) display antitumor activity in vitro and in vivo.

Hum Gene Ther 2019 Feb 22. Epub 2019 Feb 22.

Instituto Nacional de Câncer, Coordenação de Pesquisa, Rio de Janeiro, Rio de Janeiro, Brazil.

CAR T cell immunotherapy for the treatment of cancer is now an approved treatment for B-cell malignancies. However, the use of viral vectors to provide long-term CAR expression is associated with high production costs and cumbersome quality controls, impacting the final cost of CAR-T cell therapies. Non-viral integrative vectors such as Sleeping Beauty (SB) transposons provide an alternative to modify primary T cells. Read More

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http://dx.doi.org/10.1089/hum.2018.218DOI Listing
February 2019

Cross-validation of incidental learning tasks from the WAIS-IV as a measure of memory.

Appl Neuropsychol Adult 2019 Feb 22:1-8. Epub 2019 Feb 22.

b VA Ann Arbor Healthcare System , Mental Health Service , Ann Arbor , Michigan , USA.

Although incidental learning (IL) routinely occurs in everyday life, it is infrequently assessed during neuropsychological evaluations. This study aimed to further examine the concurrent validity of IL measures based on the Vocabulary and Similarities subtests from the Wechsler Adult Intelligence Test-Fourth Edition (WAIS-IV). Participants included 43 Veterans referred for outpatient neuropsychological testing. Read More

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http://dx.doi.org/10.1080/23279095.2019.1570930DOI Listing
February 2019

Super-cognition in aging: Cognitive profiles and associated lifestyle factors.

Appl Neuropsychol Adult 2019 Feb 22:1-7. Epub 2019 Feb 22.

b Department of Psychological Medicine, Yong Loo Lin School of Medicine , National University of Singapore , Singapore , Singapore.

Previous research on older adults with superior cognitive abilities (super-cognition) has typically examined cognition using a single domain approach, which may not adequately capture the multidimensional nature of successful cognitive aging. Furthermore, the lifestyle factors associated with super-cognition have not been studied adequately. The current study examined the cognitive profiles and lifestyle factors associated with super-cognition. Read More

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http://dx.doi.org/10.1080/23279095.2019.1570928DOI Listing
February 2019

Modelling PTSD diagnosis using sleep, memory, and adrenergic metabolites: An exploratory machine-learning study.

Hum Psychopharmacol 2019 Feb 22:e2691. Epub 2019 Feb 22.

Department of Psychology, University of Cape Town, Cape Town, South Africa.

Objective: Features of posttraumatic stress disorder (PTSD) typically include sleep disturbances, impaired declarative memory, and hyperarousal. This study evaluated whether these combined features may accurately delineate pathophysiological changes associated with PTSD.

Method: We recruited a cohort of PTSD-diagnosed individuals (N = 20), trauma survivors without PTSD (TE; N = 20), and healthy controls (HC; N = 20). Read More

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http://dx.doi.org/10.1002/hup.2691DOI Listing
February 2019

Cell Fate and Developmental Regulation Dynamics by Polycomb Proteins and 3D Genome Architecture.

Bioessays 2019 Feb 22. Epub 2019 Feb 22.

Institute of Human Genetics, UMR 9002, CNRS and University of Montpellier, 34396, Montpellier, France.

Targeted transitions in chromatin states at thousands of genes are essential drivers of eukaryotic development. Therefore, understanding the in vivo dynamics of epigenetic regulators is crucial for deciphering the mechanisms underpinning cell fate decisions. This review illustrates how, in addition to its cell memory function, the Polycomb group of transcriptional regulators orchestrates temporal, cell and tissue-specific expression of master genes during development. Read More

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http://dx.doi.org/10.1002/bies.201800222DOI Listing
February 2019

Abnormal B-Cell Subset and Blimp-1-Mediated Humoral Responses Associated With Visceral Leishmaniasis Pathogenesis.

Am J Trop Med Hyg 2019 Feb 18. Epub 2019 Feb 18.

Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India.

B-cells have a spectrum of functions ranging from antibody production to antigen presentation and have additional vital roles in immune mechanisms. There is rudimentary knowledge about the role of B-cells in intracellular infections with contradictory findings. We explored the role of B-cell dysfunctions in visceral leishmaniasis (VL) pathogenesis in terms of the phenotypic and functional properties of B-cells during the course of disease. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0350DOI Listing
February 2019

Setting the beat of an internal clock: Effects of dexamphetamine on different interval ranges of temporal processing in healthy volunteers.

Psych J 2019 Feb 21. Epub 2019 Feb 21.

Faculty of Medicine, Dentistry and Health Sciences, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Western Australia, Australia.

Drug studies are powerful models to investigate the neuropharmacological mechanisms underlying temporal processing in humans. This study administered dexamphetamine to 24 healthy volunteers to investigate time perception at different time scales, along with contributions from working memory. Healthy volunteers were administered 0. Read More

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http://dx.doi.org/10.1002/pchj.274DOI Listing
February 2019

Vascular and Non-vascular Contributors to Memory Reduction During Traumatic Brain Injury.

Eur J Neurosci 2019 Feb 21. Epub 2019 Feb 21.

Department of Physiology, University of Louisville, School of Medicine, Louisville, KY, USA.

Traumatic brain injury (TBI) is an increasing health problem. It is a complex, progressive disease that consists of many factors affecting memory. Studies have shown that increased blood-brain barrier (BBB) permeability initiates pathological changes in neuro-vascular network but the role of cerebrovascular dysfunction and its mediated mechanisms associated with memory reduction during TBI are still not well understood. Read More

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http://dx.doi.org/10.1111/ejn.14390DOI Listing
February 2019

Skewed B cell receptor repertoire and reduced antibody avidity in patients with DOCK8 deficiency.

Scand J Immunol 2019 Feb 21:e12759. Epub 2019 Feb 21.

Division of Immunology, Children's Hospital of Chongqing Medical University, Chongqing, China.

DOCK8 immunodeficiency syndrome (DIDS) is a combined immunodeficiency characterized by recurrent viral infections, severe atopy, and early onset malignancy. Immunological abnormalities include lymphopenia, CD8 T cell cytoskeleton dysfunction, defective B cell memory, and variable serum immunoglobulin levels. Here, we analyze the B cell receptor repertoire (BCR) characteristics and antibody avidity of four DIDS patients, attempt to understand the dysregulated humoral immunity in DIDS patients with a normal antibody titer, and suggest a scientific basis for intravenous immunoglobulin (IVIG) replacement therapy for these patients. Read More

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http://dx.doi.org/10.1111/sji.12759DOI Listing
February 2019

Time-varying whole-brain functional network connectivity coupled to task engagement.

Netw Neurosci 2019 1;3(1):49-66. Epub 2018 Oct 1.

Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, TX, USA.

Brain functional connectivity (FC), as measured by blood oxygenation level-dependent (BOLD) signal, fluctuates at the scale of 10s of seconds. It has recently been found that whole-brain dynamic FC (dFC) patterns contain sufficient information to permit identification of ongoing tasks. Here, we hypothesize that dFC patterns carry fine-grained information that allows for tracking short-term task engagement levels (i. Read More

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http://dx.doi.org/10.1162/netn_a_00051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326730PMC
October 2018

In-memory computing on a photonic platform.

Sci Adv 2019 Feb 15;5(2):eaau5759. Epub 2019 Feb 15.

Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PH, UK.

Collocated data processing and storage are the norm in biological computing systems such as the mammalian brain. As our ability to create better hardware improves, new computational paradigms are being explored beyond von Neumann architectures. Integrated photonic circuits are an attractive solution for on-chip computing which can leverage the increased speed and bandwidth potential of the optical domain, and importantly, remove the need for electro-optical conversions. Read More

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http://dx.doi.org/10.1126/sciadv.aau5759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377270PMC
February 2019

Adrenal Aging and Its Implications on Stress Responsiveness in Humans.

Front Endocrinol (Lausanne) 2019 7;10:54. Epub 2019 Feb 7.

School of Medicine, European University Cyprus, Nicosia, Cyprus.

Normal aging results in subtle changes both in ACTH and cortisol secretion. Most notable is the general increase in mean daily serum cortisol levels in the elderly, without a noteworthy alteration in the normal circadian rhythm pattern. Glucocorticoid excess seen in the elderly population can have serious consequences in both the structural and functional integrity of various key areas in the brain, including the hippocampus, amygdala, prefrontal cortex, with consequent impairment in normal memory, cognitive function, and sleep cycles. Read More

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http://dx.doi.org/10.3389/fendo.2019.00054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374303PMC
February 2019

Executive Functions and Language: Their Differential Influence on Mono- vs. Multilingual Spelling in Primary School.

Front Psychol 2019 6;10:97. Epub 2019 Feb 6.

Research Group: Diversity and Inclusion, Human Sciences Faculty, University of Potsdam, Potsdam, Germany.

We aimed at unveiling the role of executive functions (EFs) and language-related skills in spelling for mono- versus multilingual primary school children. We focused on EF and language-related skills, in particular lexicon size and phonological awareness (PA), because these factors were found to predict spelling in studies predominantly conducted with monolinguals, and because multilingualism can modulate these factors. There is evidence for (a) a in EF due to constant high cognitive demands through language control, (b) a smaller mental lexicon in German and (c) possibly better PA. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374619PMC
February 2019

Phosphodiesterase 1b (PDE1B) Regulates Spatial and Contextual Memory in Hippocampus.

Front Mol Neurosci 2019 7;12:21. Epub 2019 Feb 7.

Dart NeuroScience, LLC, San Diego, CA, United States.

Augmentation of cyclic nucleotide signaling through inhibition of phosphodiesterase (PDE) activity has long been understood to enhance memory. Efforts in this domain have focused predominantly on PDE4, a cAMP-specific phosphodiesterase implicated in consolidation. But less is known about the function of other PDEs expressed in neuroanatomical regions critical to memory. Read More

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http://dx.doi.org/10.3389/fnmol.2019.00021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374598PMC
February 2019

Tackling the Challenges of FASTQ Referential Compression.

Bioinform Biol Insights 2019 14;13:1177932218821373. Epub 2019 Feb 14.

Facultad de Ciencias y Tecnología (FaCyT), Universidad de Carabobo (UC), Valencia, Venezuela.

The exponential growth of genomic data has recently motivated the development of compression algorithms to tackle the storage capacity limitations in bioinformatics centers. Referential compressors could theoretically achieve a much higher compression than their non-referential counterparts; however, the latest tools have not been able to harness such potential yet. To reach such goal, an efficient encoding model to represent the differences between the input and the reference is needed. Read More

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http://dx.doi.org/10.1177/1177932218821373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376532PMC
February 2019

Single Cell Profiling Reveals PTEN Overexpression in Influenza-Specific B cells in Aging HIV-infected individuals on Anti-retroviral Therapy.

Sci Rep 2019 Feb 21;9(1):2482. Epub 2019 Feb 21.

University of Miami, Miller School of Medicine, Department of Microbiology and Immunology, Miami, Florida, USA.

Memory B cells (MBC) respond to secondary antigen challenge to protect against infection and to boost immunity following vaccinations. Despite effective treatment, chronic HIV infection disturbs MBCs by reducing numbers and altering functionality due to hyper-activation and increased apoptosis leading to suboptimal antibody responses against common infectious agents. We used single cell gene expression analysis to evaluate antigen-specific memory B cells in peripheral blood of virally-suppressed HIV-infected individuals and healthy controls stratified by serum H1N1 antibody response 3 weeks post-administration of the seasonal trivalent inactivated influenza vaccine. Read More

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http://dx.doi.org/10.1038/s41598-019-38906-yDOI Listing
February 2019

Heat flow due to time-delayed feedback.

Sci Rep 2019 Feb 21;9(1):2491. Epub 2019 Feb 21.

Institut für Theoretische Physik, Hardenbergstr. 36, Technische Universität Berlin, D-10623, Berlin, Germany.

Many stochastic systems in biology, physics and technology involve discrete time delays in the underlying equations of motion, stemming, e. g., from finite signal transmission times, or a time lag between signal detection and adaption of an apparatus. Read More

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http://dx.doi.org/10.1038/s41598-019-39320-0DOI Listing
February 2019

Association of IL1RAP-related genetic variation with cerebrospinal fluid concentration of Alzheimer-associated tau protein.

Sci Rep 2019 Feb 21;9(1):2460. Epub 2019 Feb 21.

Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

A possible involvement of the gene IL1RAP (interleukin-1 receptor-associated protein) in the pathogenesis of Alzheimer's disease (AD) has been suggested in GWASs of cerebrospinal fluid (CSF) tau levels and longitudinal change in brain amyloid burden. The aim of this study was to examine previously implicated genetic markers in and near IL1RAP in relation to AD risk, CSF tau and Aβ biomarkers, as well as cognitive decline, in a case (AD)-control study and an age homogenous population-based cohort. Genotyping of IL1RAP-related single nucleotide polymorphisms (SNPs), selected based on previous GWAS results, was performed. Read More

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http://dx.doi.org/10.1038/s41598-018-36650-3DOI Listing
February 2019

Downregulation of Npas4 in parvalbumin interneurons and cognitive deficits after neonatal NMDA receptor blockade: relevance for schizophrenia.

Transl Psychiatry 2019 Feb 21;9(1):99. Epub 2019 Feb 21.

Department of Psychology, The Ohio State University, 225 Psychology Building, 1835 Neil Avenue, Columbus, Ohio, 43210, USA.

Dysfunction of prefrontal parvalbumin (PV+) interneurons has been linked with severe cognitive deficits as observed in several neurodevelopmental disorders including schizophrenia. However, whether a specific aspect of PV+ neurons deregulation, or a specific molecular mechanism within PV+ neurons is responsible for cognitive deficits and other behavioral impairments remain to be determined. Here, we induced cognitive deficits and altered the prefrontal PV system in mice by exposing them neonatally to the NMDA receptor antagonist ketamine. Read More

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http://dx.doi.org/10.1038/s41398-019-0436-3DOI Listing
February 2019

Quantum interface of an electron and a nuclear ensemble.

Science 2019 Feb 21. Epub 2019 Feb 21.

Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK.

Coherent excitation of an ensemble of quantum objects underpins quantum many-body phenomena and offers the opportunity to realize a memory that stores quantum information. Thus far, a deterministic and coherent interface between a spin qubit and such an ensemble has remained elusive. Here, we first use an electron to cool the mesoscopic nuclear-spin ensemble of a semiconductor quantum dot to the nuclear sideband-resolved regime. Read More

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http://dx.doi.org/10.1126/science.aaw2906DOI Listing
February 2019

The nature of recollection across months and years and after medial temporal lobe damage.

Proc Natl Acad Sci U S A 2019 Feb 21. Epub 2019 Feb 21.

Veterans Affairs San Diego Healthcare System, San Diego, CA 92161;

We studied the narrative recollections of memory-impaired patients with medial temporal lobe (MTL) damage who took a 25-min guided walk during which 11 planned events occurred. The recollections of the patients, recorded directly after the walk, were compared with the recollections of controls tested directly after the walk (C1), after one month (C2), or after 2.6 years (C3). Read More

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http://dx.doi.org/10.1073/pnas.1820765116DOI Listing
February 2019

Underdevelopment of the Human Hippocampus in Callosal Agenesis: An In Vivo Fetal MRI Study.

AJNR Am J Neuroradiol 2019 Feb 21. Epub 2019 Feb 21.

From the Croatian Institute for Brain Research (V.K., A.Š., M.V.), School of Medicine, University of Zagreb, Zagreb, Croatia.

Background And Purpose: In subjects with agenesis of the corpus callosum, a variety of structural brain alterations is already present during prenatal life. Quantification of these alterations in fetuses with associated brain or body malformations (corpus callosum agenesis and other related anomalies) and so-called isolated cases may help to optimize the challenging prognostic prenatal assessment of fetuses with corpus callosum agenesis. This fetal MR imaging study aimed to identify differences in the size of the prenatal hippocampus between subjects with isolated corpus callosum agenesis, corpus callosum agenesis and other related anomalies, and healthy controls. Read More

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http://dx.doi.org/10.3174/ajnr.A5986DOI Listing
February 2019

Role of IFNγ in immune-mediated graft failure occurring after allogeneic hematopoietic stem cell transplantation.

Haematologica 2019 Feb 21. Epub 2019 Feb 21.

Bambino Gesù Children Hospital and Sapienza, University of Rome, Roma, Italy.

Pathophysiology of graft failure occurring after allogeneic hematopoietic stem cell transplantation still remains elusive. We measured serum levels of several different cytokines/chemokines in 15 children experiencing graft failure, comparing their values with those of 15 controls who had sustained donor cell engraftment. Already at day +3 after transplantation, patients developing graft failure had serum levels of IFNγ and CXCL9, a chemokine specifically induced by IFNγ, significantly higher than those of controls (8859±7502 versus 0 pg/ml, p=0. Read More

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http://dx.doi.org/10.3324/haematol.2019.216101DOI Listing
February 2019

Broadly Neutralizing Antibodies against HIV: Back to Blood.

Trends Mol Med 2019 Feb 18. Epub 2019 Feb 18.

Divisions of Vaccine Research and Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Medicine, Baltimore VA Medical Center, Baltimore, MD 21201, USA. Electronic address:

After years of continuous exposure to HIV envelope antigens, a minority of HIV-infected individuals develop a cognate polyclonal humoral response comprising very potent and extremely cross-reactive neutralizing antibodies [broadly neutralizing antibodies (bNAbs)]. Isolated bNAbs derived from memory B cell pools have been the focus of intense studies over the past decade. However, it is not yet known how to translate the features of bNAbs into practical HIV prevention methods. Read More

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http://dx.doi.org/10.1016/j.molmed.2019.01.007DOI Listing
February 2019

Ethnoracial differences in Alzheimer's disease from the FLorida Autopsied Multi-Ethnic (FLAME) cohort.

Alzheimers Dement 2019 Feb 12. Epub 2019 Feb 12.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

Introduction: Our primary goal was to examine demographic and clinicopathologic differences across an ethnoracially diverse autopsy-confirmed cohort of Alzheimer's disease cases.

Methods: A retrospective study was conducted in the Florida Autopsied Multi-Ethnic cohort on 1625 Alzheimer's disease cases, including decedents who self-reported as Hispanic/Latino (n = 67), black/African American (n = 19), and white/European American (n = 1539).

Results: Hispanic decedents had a higher frequency of family history of cognitive impairment (58%), an earlier age at onset (median age of 70 years), longer disease duration (median of 12 years), and lower MMSE proximal to death (median of 4 points) compared with the other ethnoracial groups. Read More

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http://dx.doi.org/10.1016/j.jalz.2018.12.013DOI Listing
February 2019

Effects of MitraClip on cognitive and psychological function in heart failure patients: the sicker the better.

Eur J Med Res 2019 Feb 22;24(1):14. Epub 2019 Feb 22.

Department of Cardiology, Angiology, Pneumology, Medical Hospital, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

Purpose: Cognitive impairment and reduced quality of life is a common condition in patients with heart failure (HF). Percutaneous mitral valve repair using (PMVR) MitraClip (MC) has emerged as a promising interventional tool, reducing all-cause mortality and hospitalization as well as increasing cognitive functioning and quality of life. However, the benefit of HF patients with severely depressed cognitive functioning remains unknown. Read More

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http://dx.doi.org/10.1186/s40001-019-0371-zDOI Listing
February 2019

Sleep oscillation-specific associations with Alzheimer's disease CSF biomarkers: novel roles for sleep spindles and tau.

Mol Neurodegener 2019 Feb 21;14(1):10. Epub 2019 Feb 21.

Department of Psychiatry, NYU School of Medicine, New York, NY, 10016, USA.

Background: Based on associations between sleep spindles, cognition, and sleep-dependent memory processing, here we evaluated potential relationships between levels of CSF Aβ, P-tau, and T-tau with sleep spindle density and other biophysical properties of sleep spindles in a sample of cognitively normal elderly individuals.

Methods: One-night in-lab nocturnal polysomnography (NPSG) and morning to early afternoon CSF collection were performed to measure CSF Aβ, P-tau and T-tau. Seven days of actigraphy were collected to assess habitual total sleep time. Read More

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http://dx.doi.org/10.1186/s13024-019-0309-5DOI Listing
February 2019

Serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patients.

BMC Nephrol 2019 Feb 21;20(1):63. Epub 2019 Feb 21.

Department of Nephrology, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430033, People's Republic of China.

Background: Hemodialysis patients suffer from a serious threat of cerebrovascular disease. Klotho, as an aging-suppressor gene, contributes to protect on vascular calcification and oxidative stress, which are the risk factors of cerebrovascular disease. The purpose of the present study is to determine the relationship between serum klotho and cerebrovascular disease in patients receiving hemodialysis. Read More

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http://dx.doi.org/10.1186/s12882-019-1232-2DOI Listing
February 2019

Exercise challenge alters Default Mode Network dynamics in Gulf War Illness.

BMC Neurosci 2019 Feb 21;20(1). Epub 2019 Feb 21.

Chronic Pain and Fatigue Research Center, Georgetown University Medical Center, Pre-Clinical Science Building, Rm LD3, 3800 Reservoir Road NW, Washington, DC, 20007, USA.

Background: Gulf War Illness (GWI) affects 30% of veterans from the 1991 Gulf War and has no known cause. Everyday symptoms include pain, fatigue, migraines, and dyscognition. A striking syndromic feature is post-exertional malaise (PEM). Read More

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http://dx.doi.org/10.1186/s12868-019-0488-6DOI Listing
February 2019

Deep Brain Stimulation and Cognitive Outcomes Among Patients With Parkinson's Disease: A Historical Cohort Study.

J Neuropsychiatry Clin Neurosci 2019 Feb 22:appineuropsych18050118. Epub 2019 Feb 22.

From the Translational Neuroscience and Aging Laboratory, Mayo Clinic, Phoenix, Ariz. (Krell-Roesch, Velgos, Geda); the Department of Psychiatry and Psychology, Mayo Clinic, Phoenix, Ariz. (Kirlin, Geda); the Department of Neurological Surgery, Phoenix, Ariz. (Lyons); and the Department of Neurology, Mayo Clinic, Phoenix, Ariz. (Geda, Mehta).

Objective:: Deep brain stimulation (DBS) is an effective treatment for motor symptoms of Parkinson's disease; however, there is conflicting literature about the effect of DBS on cognitive function. The authors conducted a historical cohort study involving patients with Parkinson's disease who underwent DBS of the globus pallidus pars interna (GPi; N=12) or subthalamic nucleus (STN; N=17).

Methods:: The authors investigated differences in four neuropsychological test scores at 6 months post-DBS (follow-up) as compared with baseline (i. Read More

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http://dx.doi.org/10.1176/appi.neuropsych.18050118DOI Listing
February 2019

High-Performance Resistance-Switchable Multilayers of Graphene Oxide Blended with 1,3,4-Oxadiazole Acceptor Nanocomposite.

Authors:
Lei Li Guangming Li

Micromachines (Basel) 2019 Feb 20;10(2). Epub 2019 Feb 20.

Key Laboratory of Functional Inorganic Material Chemistry (MOE), School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, China.

Graphene oxide (GO) has been actively utilized in nonvolatile resistive switching random access memory (ReRAM) devices due to solution-processability, accessibility for highly scalable device fabrication for transistor-based memory, and cross-bar memory arrays. Uncontrollable oxygen functional groups of GO, however, restrict its application. To obtain stable memory performance, 2-tert-butylphenyl-5-biphenyl-1,3,4-oxadiazole (PBD) a that can serve as 1,3,4-oxadiazole acceptor was carefully introduced onto the GO framework. Read More

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http://dx.doi.org/10.3390/mi10020140DOI Listing
February 2019

The Cognitive Profile of People with High-Functioning Autism Spectrum Disorders.

Behav Sci (Basel) 2019 Feb 20;9(2). Epub 2019 Feb 20.

Autism Rehabilitation Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran 1514945311, Iran.

Several studies have examined the cognitive profile of people with high-functioning autism spectrum disorders (ASD) (IQ > 70), and its relationship with the symptoms of ASD and attention deficit hyperactivity disorder (ADHD), using the Wechsler Intelligence Scale for Children-IV (WISC-IV). However, no data exist on the similarities or differences in this profile in less affluent countries. The present study examined the cognitive profile and its relationship with the symptoms of ASD and ADHD in 30 subjects aged 6⁻16 years with high-functioning ASD and compared the results with those of 30 typically developing (TD) subjects. Read More

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http://dx.doi.org/10.3390/bs9020020DOI Listing
February 2019

Toughened Poly(Lactic Acid)-PLA Formulations by Binary Blends with Poly(Butylene SuccinateAdipate)-PBSA and Their Shape Memory Behaviour.

Materials (Basel) 2019 Feb 19;12(4). Epub 2019 Feb 19.

Technological Institute of Materials (ITM), Universitat Politècnica de València (UPV), Plaza Ferrándiz y Carbonell 1, 03801 Alcoy, Spain.

This study reports the effect of poly(butylene succinateadipate) (PBSA) on the mechanical performance and shape memory behavior of poly(lactic acid) (PLA) specimens that were manufactured by injection molding and hot-press molding. The poor miscibility between PLA and PBSA was minimized by the addition of an epoxy styrene-acrylic oligomer (ESAO), which was commercially named Joncryl. It was incorporated during the extrusion process. Read More

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http://dx.doi.org/10.3390/ma12040622DOI Listing
February 2019

An LSTM-Based Method with Attention Mechanism for Travel Time Prediction.

Sensors (Basel) 2019 Feb 19;19(4). Epub 2019 Feb 19.

Department of Computer Science and Technology, Tsinghua University, Beijing 100084, China

Traffic prediction is based on modeling the complex non-linear spatiotemporal traffic dynamics in road network. In recent years, Long Short-Term Memory has been applied to traffic prediction, achieving better performance. The existing Long Short-Term Memory methods for traffic prediction have two drawbacks: they do not use the departure time through the links for traffic prediction, and the way of modeling long-term dependence in time series is not direct in terms of traffic prediction. Read More

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http://dx.doi.org/10.3390/s19040861DOI Listing
February 2019

Evaluation of the major histocompatibility complex (MHC) class II as a candidate for sudden acquired retinal degeneration syndrome (SARDS) in Dachshunds.

Vet Ophthalmol 2019 Feb 21. Epub 2019 Feb 21.

Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California.

Objective: Sudden acquired retinal degeneration syndrome (SARDS) is one of the leading causes of acute blindness in dogs, with an unknown etiology and no effective treatment. Certain breeds such as Dachshunds are overrepresented among SARDS patients, and therefore, the syndrome is suspected to have a genetic component. The objective of this study was to determine if a genetic locus associated with SARDS in Dachshunds could be identified using a genome-wide association study (GWAS). Read More

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http://dx.doi.org/10.1111/vop.12646DOI Listing
February 2019

The Role of Motor Competences in Predicting Working Memory Maintenance and Preparatory Processing.

Child Dev 2019 Feb 21. Epub 2019 Feb 21.

University of Basel.

The purpose of the study was the examination of the longitudinal association between motor competences and changes in preparatory processing during a task requiring working memory maintenance. At baseline, 52 Caucasian children aged 10-12 years completed the MOBAK-5 test battery and a Sternberg task, whereas the cue-P300 and the initial contingent negative variation (iCNV) were recorded via electroencephalography. After 9 months, the Sternberg task was administered again to assess changes in these neurophysiological indices and behavioral performance. Read More

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http://dx.doi.org/10.1111/cdev.13227DOI Listing
February 2019