9,060 results match your criteria Melasma


Giant congenital melanocytic nevus in a Cameroonian child: a case report.

J Med Case Rep 2018 Jun 23;12(1):175. Epub 2018 Jun 23.

Department of Internal Medicine and Sub-specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

Background: Giant congenital melanocytic nevus is a very rare condition characterized by a large skin lesion and an increased risk of complications like neurocutaneous melanosis and malignant transformation. Reports of giant congenital melanocytic nevus are scarce in the sub-Saharan African literature and here we present a case of this disease in a Cameroonian adolescent.

Case Presentation: A 12-year-old Cameroonian girl from the "Baka" ethnic group, with no relevant family and medical histories presented with a progressively extensive brownish-black nodular hypertrophic skin lesion of approximately 45 cm, which she had had since she was 2-days old. Read More

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Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Periodontol 2018 Jun;89 Suppl 1:S74-S84

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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June 2018
2 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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June 2018
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Granulomatous Tumoral Melanosis Associated With Pembrolizumab Therapy: A Mimicker of Disease Progression in Metastatic Melanoma.

Am J Dermatopathol 2018 Jul;40(7):523-526

Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada.

Immune checkpoint inhibitor therapy has revolutionized the treatment of advanced melanoma, with these agents significantly improving survival for patients with metastatic disease. With the increasing use of these agents, the number of adverse reactions secondary to their use has also increased. Sarcoidosis and sarcoid-like reactions are one such immune checkpoint inhibitor-related adverse event. Read More

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July 2018
1 Read

Development and validation of a multidimensional questionnaire for evaluating quality of life in melasma (HRQ-melasma).

An Bras Dermatol 2018 Jun;93(3):391-396

Department of Dermatology, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.

Background: Melasma has a major impact on quality of life. MELASQoL is the only validated specific psychometric instrument to evaluate melasma QoL.

Objective: To develop and validate a multidimensional questionnaire for evaluating quality of life related to facial melasma. Read More

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June 2018
1 Read

Evaluation of large clinically atypical vulvar pigmentation with RCM: atypical melanosis or early melanoma?

J Eur Acad Dermatol Venereol 2018 Jun 19. Epub 2018 Jun 19.

Dermatology Department, Centre Hospitalier de Lyon Sud, Hospices civils de Lyon, Université Claude Bernard Lyon 1, Pierre Bénite France.

Background: Vulvar melanosis can occasionally be clinically challenging by mimicking an early melanoma.

Objective: To report our experience of initial evaluation and follow-up in this peculiar subset of vulvar melanosis using Reflectance Confocal Microscopy (RCM).

Methods: We retrospectively evaluated 18 consecutive cases referred for atypical vulvar pigmentations and for which melanoma was considered that underwent RCM examination and histopathological assessment. Read More

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Classification of non-tumorous skin pigmentation disorders using voting based probabilistic linear discriminant analysis.

Comput Biol Med 2018 Jun 5;99:123-132. Epub 2018 Jun 5.

School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore. Electronic address:

Non-tumorous skin pigmentation disorders can have a huge negative emotional impact on patients. The correct diagnosis of these disorders is essential for proper treatments to be instituted. In this paper, we present a computerized method for classifying five non-tumorous skin pigmentation disorders (i. Read More

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Herbal sun protection agents: Human studies.

Clin Dermatol 2018 May - Jun;36(3):369-375. Epub 2018 Mar 21.

Department of Dermatology, SUNY Downstate Medical Center, Brooklyn, NY.

Topical sunscreens are the mainstay for protection from ultraviolet (UV) radiation. With skin cancer rates on the rise and great interest in reversing or preventing the effects of photoaging, new molecules with potential to defend against UV damage have received a great deal of attention. Specifically, there is a growing interest in herbal substances that offer protection against the damaging effects of UV rays. Read More

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March 2018
3 Reads

Palmoplantar Keratoderma with Keratoconus.

Middle East Afr J Ophthalmol 2018 Jan-Mar;25(1):49-51

Department of Ophthalmology, University College of Medical Sciences and GTB Hospital, New Delhi, India.

Palmoplantar keratodermas (PPKs) are a rare heterogeneous group of disorders characterized by abnormal thickening of the skin of palms and soles. Ocular manifestations reported with palmer planter keratosis include scleral melanosis, macular deposits, and congenital cataract. We report, for the first time, a case of bilateral keratoconus in a patient with PPK. Read More

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Platelet-Rich Plasma Therapy in the Treatment of Recalcitrant Melasma.

Dermatol Surg 2018 Jun 5. Epub 2018 Jun 5.

Department of Dermatology, Sir Ganga Ram Hospital, New Delhi, India Department of Blood Transfusion, Sir Ganga Ram Hospital, New Delhi, India Department of Dermatology, Sir Ganga Ram Hospital, New Delhi, India.

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The effect of melasma on self-esteem: A pilot study.

Int J Womens Dermatol 2018 Mar 8;4(1):38-42. Epub 2017 Dec 8.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX.

Melasma is a common disorder of hyperpigmentation characterized by tan or brown macules and patches affecting sun-exposed areas, particularly the face. Melasma has been shown to have a significant impact on the quality of life and self-esteem of those affected. We interviewed six patients who were diagnosed with moderate-to-severe melasma with regard to the effect of their disorder on their self-esteem. Read More

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Efficacy of phototherapy to treat facial ageing when using a red versus an amber LED: a protocol for a randomised controlled trial.

BMJ Open 2018 May 31;8(5):e021419. Epub 2018 May 31.

Biophotonics Applied to Health Sciences Postgraduate Program, Universidade Nove de Julho (UNINOVE), Sao Paulo, Brazil.

Introduction: The skin undergoes morphological and physiological changes with the advancing age of an individual. These changes may be caused by intrinsic and extrinsic factors that contribute to cellular ageing and consequent skin ageing. The term photoageing is used to characterise the ageing of the skin caused by solar radiation. Read More

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May 2018
2 Reads

Acquired Brachial Cutaneous Dyschromatosis in a Middle Aged Male.

Ann Dermatol 2018 Jun 23;30(3):342-344. Epub 2018 Apr 23.

Department of Dermatology, Ewha Womans University School of Medicine, Seoul, Korea.

Acquired brachial cutaneous dyschromatosis (ABCD) is an acquired disorder of pigmentary change that presents as chronic, asymptomatic, geographic-shaped, gray-brown patches, consisting of mixed hyper and hypopigmented macules on the dorsal aspect of the forearms. We report a case of a 40-year-old male who presented with asymptomatic, multiple brown-colored macules on the outer aspects of both arms. He had no history of hypertension and had never taken angiotensin converting enzyme inhibitors. Read More

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June 2018
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Exploring pathways for sustained melanogenesis in facial melasma: an immunofluorescence study.

Int J Cosmet Sci 2018 May 30. Epub 2018 May 30.

Departamento de Dermatologia e Radioterapia, FMB-Unesp, Botucatu, SP, Brazil.

Background: The physiopathology of epidermal hypermelanization in melasma is not completely understood. Several cytokines and growth factors are increased in skin with melasma, nevertheless, nor the pathways involved in the increased αMSH expression have been adequately evaluated, nor a model for sustained focal melanogenesis is available.

Objective: To explore stimulatory pathways for epidermal pigmentation in facial melasma related to αMSH: those linked to ultraviolet radiation, oxidative stress, inflammation, neural crest pigmentation cell differentiation and antagonism of αMSH. Read More

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A report of amelanotic malignant melanoma of the esophagus diagnosed appropriately with novel markers: A case report.

Oncol Lett 2018 Jun 12;15(6):9087-9092. Epub 2018 Apr 12.

Department of Surgery 1, Faculty of Medicine, University of Fukui, Fukui 910-1193, Japan.

The present case study reported of amelanotic malignant melanoma of the esophagus. A 68-year-old man underwent laparoscopic distal gastrectomy for early gastric cancer diagnosis. After gastrectomy, endoscopic examination revealed a protruded lesion lying adjacent to the melanosis area of the esophagus. Read More

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Pigmented transverse nasal band: A distinct presentation.

J Cosmet Dermatol 2018 May 28. Epub 2018 May 28.

Skin Disease Centre, Nashik, India.

Pigmented transverse nasal band (PTNB) is an interesting morphological entity mainly of cosmetic concern. It is believed to be related to a defect in the development of the nasal cartilages and bones from childhood to adolescence. Some patients may have genetic predisposition. Read More

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May 2018
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[Focus on clinical and pathological management of conjunctival melanocytic tumors].

Ann Pathol 2018 May 23. Epub 2018 May 23.

Laboratoire de pathologie clinique et expérimentale, pavillon J, hôpital Pasteur, CHU de Nice, 30, voie Romaine, CS 51069, 06001 Nice cedex 1, France; Institute of research on cancer and aging de Nice (IRCAN), Inserm U1081/CNRS UMR7284, UFR de médecine, 28, avenue Valombrose, 06107 Nice cedex 2, France; FHU OncoAge Nice, 30, avenue de la voie Romaine, CS 51069, 06001 Nice cedex 1, France.

Conjunctival-pigmented tumors are rare, but they are one of the most commonly encountered by the pathologist working with the department of ophthalmology. Nevus and melanoma can be encountered and have some histological difference compared to their cutaneous counterpart. Primary acquired melanosis (PAM) is a conjunctival specific entity. Read More

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Evaluation Instruments for Quality of Life Related to Melasma: An Integrative Review.

Clinics (Sao Paulo) 2018 May 21;73:e65. Epub 2018 May 21.

Departamento de Dermatologia e Radioterapia, Faculdade de Medicina, Universidade Paulista Julio de Mesquita Filho, Botucatu, SP, BR.

The aim of this study was to analyze scientific production concerning the validation and cultural adaptation of quality of life evaluation instruments for patients with melasma and to offer a critical reflection on these methods. A literature review was performed based on a search of the Web of Science, Bireme, PubMed, Elsevier Scopus, and Google Scholar databases. All published articles from indexed periodicals in these electronic databases up to December 2015 were included. Read More

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May 2018
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Detection of hydroquinone by Raman spectroscopy in patients with melasma before and after treatment.

Skin Res Technol 2018 May 23. Epub 2018 May 23.

Terahertz Science and Technology Center (C2T2) and Terahertz Science and Technology National Lab (LANCyTT), Universidad Autónoma de San Luis Potosí, San Luis Potosi, México.

Background: Melasma is an acquired, facial hyperpigmentation without a specific origin. It is regularly associated with multiple etiologic factors such as pregnancy, genetic, racial, and from estrogen administration. Among the methods to treat skin hyperpigmentation a series of skin bleaching agents have been used. Read More

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May 2018
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Early onset of diffuse melanosis cutis under pembrolizumab therapy illustrates the limitations of anti-PD-1 checkpoint inhibitors.

Melanoma Res 2018 May 17. Epub 2018 May 17.

Department of Dermatology, Venereology and Allergology.

Anti-PD-1 targeted immunotherapies have revolutionized the treatment of advanced melanoma and other tumor entities, and long disease-free intervals have been reported in responding patients. However, a considerable number of patients still progress rapidly after the start of anti-PD-1 antibodies. Here, we document two patients, 78 and 85-year old, who suffered from advanced BRAF-V600 wild-type melanoma and received pembrolizumab 2 mg/kg every 3 weeks as the first systemic treatment. Read More

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Study of hyperpigmentation in human skin disorder using different electron microscopy techniques.

Microsc Res Tech 2018 May 18. Epub 2018 May 18.

Department of Structure and Function of Neural Network, Korea Brain Research Institute, Daegu, 41068, Korea.

There is a global trend of increase in the demand for three-dimensional electron microscopy with high resolution. The ultrastructural change and related functional studies are necessary to investigate biological phenomena. In this study, currently available 3D reconstruction techniques of electron microscopes (serial block-face scanning electron microscopy and focused ion beam-scanning electron microscopy) were used to investigate hyperpigmentary disorders in human skin. Read More

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May 2018
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Inhibitors of Melanogenesis: An Updated Review.

J Med Chem 2018 May 24. Epub 2018 May 24.

College of Pharmacy and Institute of Drug Research and Development , Chungnam National University , Daejeon 34134 , Korea.

Melanins are pigment molecules that determine the skin, eye, and hair color of the human subject to its amount, quality, and distribution. Melanocytes synthesize melanin and provide epidermal protection from various stimuli, such as harmful ultraviolet radiation, through the complex process called melanogenesis. However, serious dermatological problems occur when there is excessive production of melanin in different parts of the human body. Read More

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Factors associated with quality of life in facial melasma: a cross-sectional study.

Int J Cosmet Sci 2018 May 7. Epub 2018 May 7.

Departamento de Dermatologia e Radioterapia, FMB-Unesp, Botucatu, SP, Brazil.

Background: Melasma is a common chronic focal hypermelanosis that affects photexposed areas as face, mainly in women at fertile age. It inflicts a significant impact in quality of life, nevertheless, quality of life scores (e.g. Read More

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Overexpression of EZH2 in conjunctival melanoma offers a new therapeutic target.

J Pathol 2018 May 7. Epub 2018 May 7.

Department of Ophthalmology, Leiden University Medical Centre, Leiden, The Netherlands.

Malignant melanoma of the conjunctiva (CM) is an uncommon but potentially deadly disorder. Many malignancies show an increased activity of the epigenetic modifier enhancer of zeste homolog 2 (EZH2). We studied whether EZH2 is expressed in CM, and whether it may be a target for therapy in this malignancy. Read More

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May 2018
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A split-face study: comparison of picosecond alexandrite laser and Q-switched Nd:YAG laser in the treatment of melasma in Asians.

Lasers Med Sci 2018 May 7. Epub 2018 May 7.

Graduate Institute of Biochemical and Biomedical Engineering, College of Engineering, Chang Gung University, Taoyuan, Taiwan.

To evaluate efficacy and safety of picosecond 755 nm alexandrite laser as compared to 1064 nm QS-Nd:YAG laser for melasma treatment in Asians. Twelve patients received 4 sessions of treatments at 1-month interval in a split-face manner. The right side of each patient's face received 755 nm picosecond laser, and the other side received 1064 nm QS-Nd:YAG laser. Read More

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Poria cocos Wolf extracts represses pigmentation in vitro and in vivo.

Cell Mol Biol (Noisy-le-grand) 2018 Apr 30;64(5):80-84. Epub 2018 Apr 30.

Department of Beauty Care & Cosmetics, Osan University, Osan, Gyeonggi 18119, Republic of Korea.

In skin, melanocytes determine skin color using melanogenesis, which induces protective mechanism to oxidative stress and UV damage. However, when melanin is excessive produced by the various stimulus, the accumulated melanin induces hyperpigmentation disease such as melasma, freckles, Melanism ware induced. Therefore, it is implicated to finding potential agents for whitening to be used in cosmetic products. Read More

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Physiological characterization of ocular melanosis-affected canine melanocytes.

Vet Ophthalmol 2018 Apr 27. Epub 2018 Apr 27.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.

Objective: Cairn terriers with ocular melanosis (OM) accumulate large, heavily pigmented melanocytes in the anterior uvea. Darkly pigmented plaques develop within the sclera, leading us to hypothesize that OM uveal melanocytes may have an abnormal migratory capacity.

Animals Studied: Globes from OM-affected Cairn terriers and unaffected control eyes enucleated for reasons unrelated to this study were used for immunohistochemistry and to culture melanocytes for in vitro cell behavior assays. Read More

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Unusual case of simple urinary bladder melanosis with complete resolution.

BMJ Case Rep 2018 Apr 25;2018. Epub 2018 Apr 25.

Department of Urology, Kettering General Hospital NHS Foundation Trust, Kettering, UK.

A 66-year-old man presented with a long history of recurrent attacks of urinary retention and lower urinary tract symptoms. Flexible cystoscopy showed a urethral stricture. Follow-up cystoscopy 7 years later for recurrent symptoms demonstrated unusual extensive mucosal brown to black pigmentation, which proved histopathologically to be a simple bladder melanosis. Read More

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April 2018
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Metastatic melanoma with diffuse melanosis histologically after stable response to talimogene laherparepvec therapy.

JAAD Case Rep 2018 May 4;4(4):379-381. Epub 2018 Apr 4.

Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan.

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Oral Tranexamic Acid for the Treatment of Melasma: A Review.

Dermatol Surg 2018 Jun;44(6):814-825

Skin and Cancer Foundation Inc., Melbourne, Australia.

Background: Melasma is a common acquired disorder of hyperpigmentation that commonly affects those with skin of color. Tranexamic acid (TXA) is a novel treatment for melasma that has a multimodal mechanism of action.

Objective: To provide a comprehensive review of the literature regarding the evidence on the mode of action, safety profile, and efficacy of TXA in the treatment of melasma. Read More

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June 2018
7 Reads
2.11 Impact Factor

The Safety and Efficacy of Treatment With a 1,927-nm Diode Laser With and Without Topical Hydroquinone for Facial Hyperpigmentation and Melasma in Darker Skin Types.

Dermatol Surg 2018 Apr 13. Epub 2018 Apr 13.

Goldman, Butterwick, Groff, Fabi & Wu, Cosmetic Laser Dermatology, San Diego, California.

Background: The nonablative, fractional, 1,927-nm diode laser is theoretically a safe and effective treatment for hyperpigmentation and melasma in darker skin and may potentiate topical cosmeceutical delivery.

Objective: To evaluate the use of a nonablative, fractional, 1,927-nm diode laser with and without topical 2% hydroquinone (HQ) cream for moderate-to-severe facial hyperpigmentation in Fitzpatrick skin Types III-V.

Methods: Forty adults underwent 4 laser treatments at 2-week intervals and were randomized to daily application of 2% HQ cream or moisturizer. Read More

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April 2018
1 Read

Dual Effect of Photobiomodulation on Melasma: Downregulation of Hyperpigmentation and Enhanced Solar Resistance-A Pilot Study.

Authors:
Daniel Barolet

J Clin Aesthet Dermatol 2018 Apr 1;11(4):28-34. Epub 2018 Apr 1.

Dr. Barolet is with the Department of Medicine, Dermatology Division, McGill University in Montreal, Québec, Canada, and with the RoseLab Skin Optics Laboratory in Laval, Canada.

Melasma is a resistant, sun-induced facial hyperpigmentation capable of remaining present for decades with ensuing psychological distress. Treatment is difficult and focuses on an array of measures to reduce skin hyperpigmentation resulting from triggered hyperactive melanocytes. The pathogenesis of melanoma is not clearly understood but it has been reported that some growth factors and specific cell-signaling pathways are involved. Read More

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April 2018
1 Read

The Rusty Ring Sign Streamlining Flat Lesion Detection in Subtle Melanosis Coli.

Clin Gastroenterol Hepatol 2018 Apr 9. Epub 2018 Apr 9.

Institute of Pathology, Saarbrücken-Rastpfuhl, Saarbrücken, Germany.

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April 2018
1 Read

Sesamol Inhibited Melanogenesis by Regulating Melanin-Related Signal Transduction in B16F10 Cells.

Int J Mol Sci 2018 Apr 7;19(4). Epub 2018 Apr 7.

Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan.

Melanin is synthesized through a series of interactions catalyzed by melanogenic enzymes such as tyrosinase, dopachrome tautomerase (tyrosinase-related protein-2; TRP-2), and tyrosinase-related protein-1 (TRP-1). Tyrosinase plays a key role in catalysing the initial and limiting steps of melanogenesis. The melanin that results from melanogenesis has the protective effect of absorbing ultraviolet radiation. Read More

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Behaviors and Attitudes Toward Cosmetic Treatments Among Men.

J Clin Aesthet Dermatol 2018 Mar 1;11(3):42-48. Epub 2018 Mar 1.

Drs. Girdwichai, Chanprapaph, and Vachiramon are with the Division of Dermatology, Faculty of Medicine Ramathibodi Hospital, Mahidol University in Bangkok, Thailand.

Cosmetic treatments have gained popularity worldwide. However, little is known about the behaviors and attitudes toward cosmetic treatments in men. The authors sought to explore the behaviors and attitudes toward cosmetic treatments in male patients. Read More

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Double-blind, Placebo-controlled Trial to Evaluate the Effectiveness of Extract in the Treatment of Melasma in Asian Skin: A Pilot Study.

J Clin Aesthet Dermatol 2018 Mar 1;11(3):14-19. Epub 2018 Mar 1.

Drs. Goh, Chuah, and Thng are with the National Skin Centre in Singapore.

Melasma is a common pigmentary disorder with a multifactorial etiology that can hinder its management. The aqueous extract of the fern (PLE), Fernblock (IFC, Madrid, Spain), has demonstrated antioxidant and photoprotective activities and has been used for the treatment of several pigmentary disorders. The aim of this study was to evaluate the efficacy and safety of oral PLE in the treatment of melasma in Asian patients. Read More

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Pathology of tail fan necrosis in the spiny lobster, Jasus edwardsii.

J Invertebr Pathol 2018 May 21;154:5-11. Epub 2018 Mar 21.

Institute of Marine Science, The University of Auckland, New Zealand; School of Biological Sciences, The University of Auckland, New Zealand.

Tail fan necrosis (TFN) is the bacterial infection of the tail fan of spiny lobsters which leads to melanosis and erosion of the tail fan tissues. The condition is commonly found among spiny lobsters in aquaculture and commercial fisheries, and greatly reduces their commercial value. This study describes the pathology of TFN by examining the tail fans (telson, uropods) and internal organs (mid-gut, hepatopancreas, heart and gill) of 29 affected wild spiny lobsters (Jasus edwardsii) and 14 unaffected in New Zealand. Read More

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May 2018
2 Reads

Gender, age, and concomitant diseases of melanosis coli in China: a multicenter study of 6,090 cases.

PeerJ 2018 8;6:e4483. Epub 2018 Mar 8.

Department of Gasterology, General Hospital of the Xinjiang Military Region, Urumqi, China.

Backgrounds And Aims: Melanosis coli (MC) is a noninflammatory, benign, and reversible colonic disorder, but its detection rates in China are unclear. We therefore aimed to analyze the epidemiological characteristics of MC in China.

Methods: We assessed the detection rates, associated factors and concomitant diseases of MC in the patients who underwent colonoscopy at eight medical centers across five regions of China between January 2006 and October 2016. Read More

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March 2018
1 Read

Rare finding of concomitant pseudomelanosis of stomach and duodenum; case report and literature review.

Gastroenterol Hepatol Bed Bench 2018 ;11(1):86-89

Division of Gastroenterology and Hepatology, SBH Health System, 4422 Third Ave, Bronx, New York, USA.

Melanosis of the stomach and duodenum is a rare entity and a striking finding diagnosed by upper gastrointestinal endoscopy. Here, we describe the case of an 83-year-old female, with a complicated medical history, who was referred to gastroenterologist to assess bleeding risk. From the endoscopy, it was determined that she had both melanosis gastri and duodeni. Read More

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January 2018
2 Reads

α-Viniferin Improves Facial Hyperpigmentation via Accelerating Feedback Termination of cAMP/PKA-Signaled Phosphorylation Circuit in Facultative Melanogenesis.

Theranostics 2018 16;8(7):2031-2043. Epub 2018 Feb 16.

College of Pharmacy, Chungbuk National University, Cheongju 28160, Korea.

cAMP up-regulates microphthalmia-associated transcription factor subtype M (MITF-M) and tyrosinase (Tyro) in the generation of heavily pigmented melanosomes. Here, we communicate a therapeutic mechanism of hyperpigmented disorder by α-viniferin, an active constituent of . We used cAMP-elevated melanocyte cultures or facial hyperpigmented patches for pigmentation assays, and applied immunoprecipitation, immunobloting, RT-PCR or reporter gene for elucidation of the antimelanogenic mechanism. Read More

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February 2018
1 Read

Treatment of melasma using tranexamic acid: what's known and what's next.

Authors:
Sarah L Sheu

Cutis 2018 Feb;101(2):E7-E8

Department of Dermatology, Stanford University Medical Center, California, USA.

Tranexamic acid is a procoagulant agent that is approved by the US Food and Drug Administration for treatment of menorrhagia and to prevent hemorrhage in patients with hemophilia undergoing tooth extractions. Through its inhibitory effects on the plasminogen activation pathway, tranexamic acid also mitigates the UV radiation-induced pigmentation response. Systemic tranexamic acid has consistently been reported as an effective treatment of melasma, though its broad use may be limited by the risk for thromboembolism. Read More

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February 2018
2 Reads

Melasma in Men: A Review of Clinical, Etiological, and Management Issues.

J Clin Aesthet Dermatol 2018 Feb 1;11(2):53-59. Epub 2018 Feb 1.

Dr. Sarkar is a professor at the Department of Dermatology, Maulana Azad Medical College in New Delhi, India.

Melasma is a common skin condition that affects both men and women. However, it is more commonly seen in women and dark-skinned individuals, such as in Hispanics, Asians, and African Americans who live in areas with intense ultraviolet radiation. Melasma is less common in men, but it negatively affects the quality of life in men as much as it does in women. Read More

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February 2018
4 Reads

Are Natural Ingredients Effective in the Management of Hyperpigmentation? A Systematic Review.

J Clin Aesthet Dermatol 2018 Feb 1;11(2):28-37. Epub 2018 Feb 1.

Dr. Hollinger is with the Department of Dermatology, University of Mississippi Medical Center in Jackson, Mississippi.

Hyperpigmentation disorders are commonly encountered in dermatology clinics. Botanical and natural ingredients have gained popularity as alternative depigmenting products. We sought to review clinical studies evaluating the use of different natural products in treating hyperpigmentation so clinicians are better equipped to educate their patients. Read More

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February 2018

Blue Nevi of the Ocular Surface: Clinical Characteristics, Pathologic Features, and Clinical Course.

Ophthalmology 2018 Mar 15. Epub 2018 Mar 15.

Bascom Palmer Eye Institute, University of Miami, Miami, Florida. Electronic address:

Purpose: Blue nevus is a melanocytic tumor that is commonly found in the skin. Extracutaneous presentations, including the ocular surface, are rare. As such, the purpose of this study was to characterize the clinical features and clinical course of congenital melanocytic tumor (blue nevus) of the conjunctiva. Read More

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March 2018
2 Reads

Nanotechnological advances for cutaneous release of tretinoin: an approach to minimize side effects and improve therapeutic efficacy.

Curr Med Chem 2018 Mar 12. Epub 2018 Mar 12.

Medicine Department - Federal University of Sao Paulo (UNIFESP). Brazil.

The clinical efficacy of the topical tretinoin is widely studied and has been well established for many therapeutic interventions, among some, photoaging, acne, and melasma. However, the side effects, mainly cutaneous irritation, erythema, xerosis and peeling, remain major obstacle to the patient compliance. Besides, the insight regarding the drug delivery profile is essential to understand the therapeutic action of the drug. Read More

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March 2018
4 Reads

Neurocutaneous Melanosis in an Adult Patient with Intracranial Primary Malignant Melanoma: Case Report and Review of the Literature.

World Neurosurg 2018 Jun 10;114:76-83. Epub 2018 Mar 10.

Department of Neurosurgery, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China. Electronic address:

Background: To explore the clinical characteristics of neurocutaneous melanosis (NCM) in adult patients to help improve diagnosis and treatment of this disease, we present a rare case of an adult patient suffering from NCM with malignant melanoma, as well as a review of the relevant Chinese and English literature.

Case Description: The patient reported here plus the patients identified in our literature review total 30 adults with NCM (20 males [66.7%] and 10 females [33. Read More

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Giant Congenital Melanocytic Nevi: An Update and Emerging Therapies.

Case Rep Dermatol 2018 Jan-Apr;10(1):24-28. Epub 2018 Feb 8.

cDepartment of Pediatrics, Richmond University Medical Center, New York, NY, USA.

Giant congenital melanocytic nevi (GCMN) are a rare occurrence. Gain-of-function mutation in the NRAS gene is found to be associated with GCMN, causing abnormal proliferation of embryonic melanoblasts. The two major complications associated with GCMN are malignant melanoma and neurocutaneous melanosis. Read More

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February 2018
2 Reads

Population-based incidence of conjunctival tumours in Olmsted County, Minnesota.

Br J Ophthalmol 2018 Mar 6. Epub 2018 Mar 6.

Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.

Aim: To determine population-based incidence of conjunctival tumours in Olmsted County, Minnesota.

Methods: The Rochester Epidemiology Project medical record linkage system was used to identify patients with conjunctival tumours in Olmsted County (1 January 1980 to 31 December 2015). Records were reviewed for demographics, types of tumours, histopathology, treatment and clinical course. Read More

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March 2018
2 Reads

CCN1/Cyr61 Stimulates Melanogenesis through Integrin α6β1, p38 MAPK, and ERK1/2 Signaling Pathways in Human Epidermal Melanocytes.

J Invest Dermatol 2018 Mar 3. Epub 2018 Mar 3.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, PR China. Electronic address:

Fibroblast-derived melanogenic paracrine mediators are known to play a role in melanogenesis. To investigate the effect of CCN1 (also called CYR61 or cysteine-rich 61) on melanogenesis, normal human epidermal melanocytes were treated with recombinant CCN1 protein. Our findings show that CCN1 activates melanogenesis through promoting melanosome maturation and up-regulation of MITF, TRP-1, and tyrosinase via the integrin α6β1, p38 MAPK, and ERK signaling pathways. Read More

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March 2018
2 Reads