9,725 results match your criteria Melasma


Coating white shrimp (Litopenaeus vannamei) with edible fully deacetylated chitosan incorporated with clove essential oil and kojic acid improves preservation during cold storage.

Int J Biol Macromol 2020 Jun 28. Epub 2020 Jun 28.

School of Food Science and Technology, State Key Laboratory of Food Science and Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Lihu Road 1800, Wuxi 214122, Jiangsu, PR China.

The effect of fully deacetylated chitosan (FDCH) edible coating combined with kojic acid (KA) and clove essential oil (CEO) as natural preservatives was investigated on the shelf-life of white prawn shrimp (Litopenaeus vannamei) during 15 days at cold storage. The results indicated that FDCH:KA:CEO coating significantly inhibited the increase in total aerobic plate count, total volatile basic nitrogen content and pH of shrimp in comparison with the control. Moreover, compared with the control, the changes of total colour difference (ΔE values) and melanosis were significantly retarded, and the texture parameters and sensory scores were significantly improved in shrimp treated by FDCH:KA:CEO suggesting that there is a synergistic effect between FDCH, KA, and CEO. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.248DOI Listing

Impact of Riehl's melanosis on quality of life in Korean patients: A cross-sectional comparative study.

J Dermatol 2020 Jun 26. Epub 2020 Jun 26.

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

The prevalence of Riehl's melanosis in Korea is increasing. However, little is known about the psychosocial burden of patients with Riehl's melanosis. This study was aimed to examine the level of psychosocial impact of Riehl's melanosis. Read More

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http://dx.doi.org/10.1111/1346-8138.15382DOI Listing

Identification of rhein as the metabolite responsible for toxicity of rhubarb anthraquinones.

Food Chem 2020 Jun 18;331:127363. Epub 2020 Jun 18.

Key Laboratory of Resource Biology and Modern Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an 710069, China; Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 710069 Xi'an, China. Electronic address:

Rhubarb is a popular food in Europe with laxative properties attributed to anthraquinones. Long term usage of rhubarb anthraquinones has been linked to colonic toxicity, including the formation of melanosis coli, which is associated with increased risk of colon cancer. The major purgative anthraquinone in rhubarb is thought to be sennoside A, which is metabolised by colonic microflora. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127363DOI Listing

A pilot study on the use of a non-crosslinked hyaluronic acid with associated anti-oxidant ingredients to improve the effectiveness of Nd:YAG Laser Toning in the treatment of melasma in six patients.

Authors:
Daniel Yip

J Cosmet Dermatol 2020 Jun 25. Epub 2020 Jun 25.

Department of Family Practice, Faculty of Medicine, University of British Columbia.

Introduction: Melasma is a common skin disorder. Nd:YAG laser toning is a popular treatment for melanin clearance. Treatment efficacy is limited by factors such as presence of reactive oxygen species, DNA damage, TEWL, and skin barrier disruption. Read More

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http://dx.doi.org/10.1111/jocd.13565DOI Listing

Clinical evaluation of efficacy, safety and tolerability of cysteamine 5% cream in comparison with modified Kligman's formula in subjects with epidermal melasma: A randomized, double-blind clinical trial study.

Skin Res Technol 2020 Jun 25. Epub 2020 Jun 25.

Department of Social Medicine, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.

Background: Kligman's formula (KF) remains to date the dermatologists' treatment of choice for melasma. This study was aimed at the evaluation of the effectiveness of Modified Kligman's formula (MKF) in comparison with cysteamine 5% cream on the severity of epidermal melasma.

Materials And Methods: A total of 50 subjects with epidermal melasma were included in this double-blind, randomized trial study. Read More

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http://dx.doi.org/10.1111/srt.12901DOI Listing

Treatment of henna-induced Riehl's melanosis with a 755-nm picosecond alexandrite laser.

Lasers Med Sci 2020 Jun 23. Epub 2020 Jun 23.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Japan.

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http://dx.doi.org/10.1007/s10103-020-03077-0DOI Listing

Comparative study between topical tranexamic acid alone versus its combination with autologous platelet rich plasma for treatment of melasma.

J Dermatolog Treat 2020 Jun 22:1-7. Epub 2020 Jun 22.

Dermatology and Venereology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Tranexamic acid is a promising drug for melasma treatment, but its topical formulation has limited efficacy. Its use as liposome based cream or in combination with other modalities might help to achieve better results. Comparing efficacy of topical tranexamic acid 5% in liposome base alone versus its combination with intradermal platelet rich plasma (PRP) for melisma treatment. Read More

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http://dx.doi.org/10.1080/09546634.2020.1781755DOI Listing

Efficacy and safety of oral tranexamic acid as an adjuvant in Indian patients with melasma: a prospective, interventional, single-centre, triple-blind, randomized, placebo-control, parallel group study.

Authors:
K Minni S Poojary

J Eur Acad Dermatol Venereol 2020 Jun 22:e16598. Epub 2020 Jun 22.

Department of Dermatology, Venereology and Leprosy, K.J. Somaiya Medical College and Research Centre, Mumbai, Maharashtra, India.

Background: Melasma is a chronic recalcitrant pigmentary disorder whose treatment frustrates physician and patient alike. Tranexamic acid, a plasmin inhibitor, has demonstrated hypopigmenting properties.

Aim: To compare safety and efficacy of combination of oral tranexamic acid (TXA) and topical fluocinolone-based combination cream (FbTC) with that of topical FbTC alone in melasma. Read More

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http://dx.doi.org/10.1111/jdv.16598DOI Listing

The diagnostic conundrum of Riehl melanosis and other facial pigmentary disorders: a case report with overlapping clinical, dermoscopic, and histopathological features.

Acta Dermatovenerol Alp Pannonica Adriat 2020 Jun;29(2):81-83

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Riehl melanosis (RM) is a form of pigmented contact dermatitis that often poses a diagnostic challenge due to overlaps in its clinical, dermoscopic, and histopathological features with other pigmentary disorders. This report highlights significant findings and the proper approach for diagnosis. We present the case of a 47-year-old female with progressive facial hyperpigmentation (irregular, blotchy, grayish patches on the forehead, cheeks, and around the mouth) that acknowledged applying a lightening product before her complaint. Read More

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A comparison of serum zinc levels in melasma and non-melasma patients: a preliminary study of thyroid dysfunction.

Acta Dermatovenerol Alp Pannonica Adriat 2020 Jun;29(2):59-62

Department of Dermatology and Venereology, Dharmais National Cancer Hospital, Jakarta, Indonesia.

Introduction: Melasma is an acquired hyperpigmentation disorder, clinically identified by symmetrical blackish-brown macules, especially on the facial area. Several factors are thought to play a role, including thyroid dysfunction and zinc deficiency. The aim of this study was to determine serum zinc levels in melasma and non-melasma patients with and without thyroid dysfunction. Read More

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Becker Melanosis.

Indian Pediatr 2020 Jun;57(6):597-598

Department of Dermatology, Venereology, and Leprosy, RG Kar Medical College, Kolkata, West Bengal, India.

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Micro-needling versus fractional carbon dioxide laser for delivery of tranexamic acid in the treatment of melasma: A split-face study.

J Cosmet Dermatol 2020 Jun 20. Epub 2020 Jun 20.

Laser Unit, Department of Dermatology, Venereology and Andrology, Al-Azhar University Faculty of Medicine, Cairo, Egypt.

Background: Tranexamic acid (TXA) in oral, topical, and intra-dermal injection routes showed efficacy in melasma treatment. Micro-needling and fractional carbon dioxide (CO ) laser were reported to enhance the drug delivery of TXA.

Aims: This study aimed at comparing the use of micro-needling and fractional CO laser for drug delivery of TXA in the treatment of facial melasma. Read More

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http://dx.doi.org/10.1111/jocd.13537DOI Listing

Melanosis of the bladder: A rare diagnosis.

Urol Case Rep 2020 Nov 27;33:101283. Epub 2020 May 27.

Urology Department, Brown University, Lifespan Health System, Providence, RI, USA.

Melanosis of the bladder is characterized by dark, velvety bladder mucosa due to melanin deposition. Less than 25 cases have been reported. We present a 45-year-old male undergoing work up for obstructive and storage irritative lower urinary tract symptoms, found to have diffuse bladder melanosis on cystoscopy with bladder biopsy, and detrusor overactivity on urodynamic study. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286983PMC
November 2020

Guanine Deaminase in Human Epidermal Keratinocytes Contributes to Skin Pigmentation.

Molecules 2020 Jun 5;25(11). Epub 2020 Jun 5.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea.

Epidermal keratinocytes are considered as the most important neighboring cells that modify melanogenesis. Our previous study used microarray to show that guanine deaminase (GDA) gene expression is highly increased in melasma lesions. Hence, we investigated the role of GDA in skin pigmentation. Read More

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http://dx.doi.org/10.3390/molecules25112637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321356PMC

The efficacy in treatment of facial melasma with thulium 1927-nm fractional laser-assisted topical tranexamic acid delivery: a split-face, double-blind, randomized controlled pilot study.

Lasers Med Sci 2020 Jun 6. Epub 2020 Jun 6.

Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Pran-nok Road, Bangkok, 10700, Thailand.

This split-face, double-blind, randomized controlled study examines the efficacy of fractional thulium laser (FTL)-assisted delivery of topical tranexamic acid (TXA) compared with FTL alone as a treatment option for melasma. Forty-six adults with Fitzpatrick skin types III-V and recalcitrant melasma underwent four weekly treatments with fractional 1927-nm thulium laser on both sides of the face. Immediately after treatment, TXA was applied to one side of the face and normal saline solution (NSS) to the contralateral side as control under occlusion. Read More

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http://dx.doi.org/10.1007/s10103-020-03045-8DOI Listing

Extensive Becker's Melanosis in a Checkerboard Mosaic Pattern.

Indian Dermatol Online J 2020 Mar-Apr;11(2):294-295. Epub 2020 Mar 9.

Department of Dermatology, Venereology and Leprology, R.N.T. Medical College, Udaipur, Rajasthan, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_137_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247657PMC

A Study of Quality of Life in Patients with Facial Melanoses.

Indian Dermatol Online J 2020 Mar-Apr;11(2):154-157. Epub 2020 Mar 9.

Essential Hospital, 42, Outer Ring Road, Marilingappa Extension, Nagarbhavi, Bengaluru, Karnataka, India.

Context: Facial melanoses decreases the quality of life (QoL). Melasma is the commonest cause but there are various other etiologies for facial pigmentation.

Aims: To study the clinical profile of patients with facial melanoses and the psychological burden in these patients. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_209_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247630PMC

Management of periorbital hyperpigmentation: An overview of nature-based agents and alternative approaches.

Dermatol Ther 2020 May 29:e13717. Epub 2020 May 29.

Department of Pharmaceutical Chemistry and Quality Assurance, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, Maharashtra, India.

Periorbital hyperpigmentation (POH) is a common dermatological condition that presents as dark periorbital area beneath the lower eyelids, and it is commonly found in females belonging to the age group of 16 to 45 years. The data presented in this review include studies conducted on patients with a clinical/histological diagnosis of POH or melasma. Many diverse topical depigmenting agents comprising an array of naturally obtained actives such as arabinoxylans, α-arbutin, asiaticoside, azelaic acid, beta-carotene, boswellic acid, caffeine, chrysin, curcumin, cyanidin-3-glucoside, d-glucoronic acid, dihydrochalcone, dipalmitoyl-hydroxyprolene, fucoxanthin, genistein, glabridin, b-glucogallin, hyaluronic acid, lactic acid, lycopene, niacinamide, pycnogenol, retinol, salidroside, and xymenynic acid demonstrated significant benefits in the management of POH. Read More

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http://dx.doi.org/10.1111/dth.13717DOI Listing

A case of acanthosis nigricans in a HIV-infected patient.

BMC Infect Dis 2020 May 20;20(1):360. Epub 2020 May 20.

Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, Italy.

Background: To date, very little information is available concerning the relationship between acanthosis nigricans (AN) and infection with human immunodeficiency virus type 1 (HIV-1).

Case Presentation: Herein, we report the case of a middle-aged man admitted for fever and progressively worsening dyspnea in the context of an opportunistic pneumonia and firstly diagnosed with acquired immunodeficiency syndrome (AIDS). At the time of diagnosis, physical examination revealed the presence of a palpable, hyperpigmented skin lesion on the left areola with surface desquamation and velvety texture consistent with AN. Read More

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http://dx.doi.org/10.1186/s12879-020-05089-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238735PMC

Dermoscopy as a useful tool for evaluating melasma and assessing the response to 1064-nm Q-switched Nd:YAG laser.

Dermatol Ther 2020 May 20:e13629. Epub 2020 May 20.

Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Melasma is a hard-to-manage disorder with considerable relapsing behavior. Dermoscopy emerged to help in comprehensive evaluation of pigmentary disorders and melasma. The aim of the study was to evaluate the potential role of dermoscopy in assessing melasma and monitoring the efficacy of 1064-nm low-fluence Q-switched neodymium:yttrium-aluminum-garnet (QS Nd:YAG) laser. Read More

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http://dx.doi.org/10.1111/dth.13629DOI Listing
May 2020
1.478 Impact Factor

A Split Face Comparative Study between Intradermal Tranexamic Acid and Erbium-YAG laser in Treatment of Melasma.

J Dermatolog Treat 2020 May 18:1-22. Epub 2020 May 18.

Dermatology medical laser department, National Institute Of laser and Enhanced Science, Cairo University, Cairo, Egypt.

: Although there are different treatment modalities of melasma, it remains a challenging problem. Erbium-YAG laser proved its efficacy in melasma improvement with minimal downtime. Tranexamic Acid is a new promising treatment of melasma: the first objective is to compare between the efficacy of intradermal injection of Tranexamic acid (TA) and Erbium-YAG laser in the treatment of melasma. Read More

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http://dx.doi.org/10.1080/09546634.2020.1771259DOI Listing

Successful Treatment of Pigmentary Disorders in Asians With a Novel 730-nm Picosecond Laser.

Lasers Surg Med 2020 May 14. Epub 2020 May 14.

Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.

Background And Objective: Until recently, quality-switched nanosecond lasers have been the workhorse lasers in treating pigmented lesions. However, the recently commercialized picosecond lasers have provided physicians with a novel method to manage pigmented lesions. Most recently, the first picosecond laser with a 730-nm wavelength was developed to specifically target melanin and melanocytes. Read More

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http://dx.doi.org/10.1002/lsm.23261DOI Listing

Efficacy of microneedling plus topical 4% tranexamic acid solution vs 4% hydroquinone in the treatment of melasma: A single-blind randomized clinical trial.

J Cosmet Dermatol 2020 May 13. Epub 2020 May 13.

Pathology and Stem Cell Research Center, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran.

Background: There are various treatment modalities for melasma, but none of them are effective on dermal component of melasma.

Aims: In this study, we decided to evaluate the efficacy of microneedling plus tranexamic acid in comparison with 4% hydroquinone in the treatment of melasma.

Methods: This is a single-blind randomized clinical trial on 70 participants with 14% dropout, and therefore, 60 patients with melasma completed the study. Read More

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http://dx.doi.org/10.1111/jocd.13392DOI Listing

Maturational Hyperpigmentation: Cutaneous Marker of Metabolic Syndrome.

Dermatol Pract Concept 2020 20;10(2):e2020046. Epub 2020 Apr 20.

Cosmasure Skin Hair, Fat Management and Laser Clinic, Jabalpur, India.

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http://dx.doi.org/10.5826/dpc.1002a46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190466PMC

Hypopigmentation as a side effect of melasma treatment with tranexamic acid intradermal microinjections.

Dermatol Ther 2020 May 2:e13503. Epub 2020 May 2.

Department of Dermatology, Charles Nicolle Hospital, Tunis, Tunisia.

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http://dx.doi.org/10.1111/dth.13503DOI Listing

Therapeutic efficacy and safety of oral tranexamic acid 250 mg once a day versus 500 mg twice a day: a comparative study.

Arch Dermatol Res 2020 Apr 30. Epub 2020 Apr 30.

Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda), 176001, Himachal Pradesh, India.

Oral tranexamic acid (TXA) 250 mg twice daily has been used effectively for 4 weeks to 6 months to treat melasma. As relapses are frequent on discontinuation, a minimum effective dose of TXA that can be used safely for long time remains unknown. We compared the efficacy of oral TXA 250 mg once daily and 500 mg twice daily given for 16 weeks in 132 (m:f 23:109) adults with melasma. Read More

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http://dx.doi.org/10.1007/s00403-020-02078-xDOI Listing

Interferon Alfa-2b for Pigmented Ocular Surface Squamous Neoplasia: A Report of 8 Lesions.

Cornea 2020 Apr 29. Epub 2020 Apr 29.

Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, India.

Purpose: To study the efficacy of interferon alfa-2b (IFN-a2b) on pigmented ocular surface squamous neoplasia (p-OSSN) and assess the resolution of the pigment to the treatment.

Methods: A retrospective case series of 8 tumors in 7 patients.

Results: The mean age at diagnosis of p-OSSN was 65 years (median, 61 years; range, 51-84 years), and all patients were men. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002350DOI Listing

Screening and Intervention for Skin Cancer in the Galapagos.

Ann Plast Surg 2020 Jul;85(S1 Suppl 1):S143-S148

Division of Plastic and Reconstructive Surgery at Stony Brook University Hospital.

Objective: This study aimed to assess the general dermatological needs and correlation of tentative skin cancer screening diagnoses with histopathological confirmation in the highly sun-exposed locals of the Galapagos Islands.

Methods: An institutional review board-approved prospective study was performed at Blanca's House, a nonprofit surgical volunteer organization, free clinics in the Galapagos. After consent, a 40-item modified SPOTme-inspired questionnaire was completed. Read More

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http://dx.doi.org/10.1097/SAP.0000000000002345DOI Listing

Study of oral tranexamic acid, topical tranexamic acid, and modified Kligman's regimen in treatment of melasma.

J Cosmet Dermatol 2020 Jun 28;19(6):1456-1462. Epub 2020 Apr 28.

JNMC, DMIMS DU, Wardha, India.

Background: Melasma is a pigmentary disorder affecting mainly face . Various treatment modalities available as topicals, superficial chemical peels and lasers but none till date gives promising results, until date quest for the best treatment modality is on.

Aim: To study the effect of oral and topical Tranexamic acid (TXA) and modified Kligman's regimen in treatment of melasma. Read More

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http://dx.doi.org/10.1111/jocd.13430DOI Listing

Photoprotection beyond ultraviolet radiation: A review of tinted sunscreens.

J Am Acad Dermatol 2020 Apr 23. Epub 2020 Apr 23.

Department of Dermatology, Henry Ford Hospital, Detroit, Michigan. Electronic address:

Ultraviolet radiation and visible light both have biologic effects on the skin. Visible light can induce erythema in light-skinned individuals and pigmentation in dark-skinned individuals. Broad-spectrum sunscreens protect against ultraviolet radiation but do not adequately protect against visible light. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.04.079DOI Listing

Differential diagnosis and management of melanocytic lesions of the ocular surface

Orv Hetil 2020 04 1;161(15):563-574. Epub 2020 Apr 1.

Semmelweis Egyetem, Budapest, Mária u. 39., 1085.

Our purpose is to summarize the actual knowledge about melanocytic lesions of the ocular surface (conjunctival nevus, primary acquired melanosis and conjunctival melanoma),especially their clinical appearance, differential diagnosis and treatment. Conjunctival nevus is the most common benign, conjunctival melanocytic lesion. Primary acquired melanosis mainly presents in middle-aged or elderly individuals, characterized by proliferation of melanocytes of the conjunctival epithelial layer. Read More

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http://dx.doi.org/10.1556/650.2020.31699DOI Listing

Serial F-FDG PET/CT findings in a patient with neurocutaneous melanosis.

Neurol Clin Pract 2020 Apr;10(2):e14-e16

Department of Pediatrics (YD, XS) and Department of Nuclear Medicine (WZ), the Affiliated Hospital of Southwest Medical University; and Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province (WZ), Luzhou, Sichuan, China.

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http://dx.doi.org/10.1212/CPJ.0000000000000700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156200PMC

Novel Combination of a 650-Microsecond Neodymium-doped Yttrium Aluminium Garnet 1,064-nm Laser and Cysteamine Cream for the Treatment of Melasma: A Case Study.

J Clin Aesthet Dermatol 2020 Mar 1;13(3):28-30. Epub 2020 Mar 1.

Drs. Johnson, Marrone, and Om are with Florida State University in Tallahassee, Florida.

Melasma is a common pigmentation disorder with few satisfactory treatment options. The hyperpigmentation has both an epidermal and dermal component. To date, combination therapies have been observed to yield greater improvements in melasma compared to monotherapies. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159306PMC

Tranexamic Acid Inhibits Angiogenesis and Melanogenesis by Targeting VEGF Receptors.

Int J Med Sci 2020 25;17(7):903-911. Epub 2020 Mar 25.

Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88, Jiefang Rd., Hangzhou, 310009, Zhejiang Province, China.

Melasma is a common but complex skin condition concerning cosmetic problems. Tranexamic acid (TA) has been proved to be effective in treatment of melasma with still unclear mechanisms. Here, we show that VEGF165 enhanced the expression of VEGF receptors (VEGFRs, including VEGFR-1, VEGFR-2 and NRP-1) in human umbilical vein endothelial cells (HUVECs), which was attenuated by TA. Read More

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http://dx.doi.org/10.7150/ijms.44188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163366PMC

Tacrolimus (FK506) ointment combined with Nb-UVB could activate both hair follicle (HF) and dermal melanocyte precursors in vitiligo: the first histopathological and clinical study.

Arch Dermatol Res 2020 Apr 17. Epub 2020 Apr 17.

Skin Research Center, Shohada-E Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Shahrdari St, 1989934148, Tehran, Iran.

Topical Tacrolimus, especially when combined with Nb-UVB, has been proven clinically to be effective in the treatment of vitiligo. However, no histological study has evaluated the repigmentation mechanism of tacrolimus ointment in combination therapy with Nb-UVB. In this study, the histological findings in patients receiving Nb-UVB were compared with those receiving topical tacrolimus combined with Nb-UVB. Read More

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http://dx.doi.org/10.1007/s00403-020-02068-zDOI Listing

Clinical improvement of photoaging-associated facial hyperpigmentation in Korean skin with a picosecond 1064-nm neodymium-doped yttrium aluminum garnet laser.

Lasers Med Sci 2020 Apr 17. Epub 2020 Apr 17.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

Traditional attempts at alleviating photoaging-associated facial pigmentation conditions such as melasma, mottled hyperpigmentation, and post-inflammatory hyperpigmentation have yielded disfiguring cosmetic results. Laser toning using a low-fluence Q-switched 1064-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser has been more commonly applied to date. However, the treatment efficacy and safety of this approach have not been widely reported. Read More

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http://dx.doi.org/10.1007/s10103-020-03008-zDOI Listing

Cutaneous Interaction with Visible Light: What Do We Know.

J Am Acad Dermatol 2020 Apr 11. Epub 2020 Apr 11.

Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO. Electronic address:

Visible light has been used therapeutically in dermatology for years for a variety of cosmetic and medical indications, including skin rejuvenation and the treatment of inflammatory and neoplastic conditions, among others. Until recently, visible light was thought to be relatively inert compared to its spectral neighbors, ultraviolet and infrared radiation. However, recent literature has described the ability of visible light to cause erythema in light skin and pigmentary changes in individuals with darker skin types. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.03.115DOI Listing

A Systematic Review of Picosecond Laser in Dermatology: Evidence and Recommendations.

Lasers Surg Med 2020 Apr 13. Epub 2020 Apr 13.

Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, Boston, Massachusetts, 02114.

Background And Objectives: The use of picosecond laser in dermatology was originally focused on optimizing the removal of unwanted tattoos. Subsequent advances in this technology have broadened its clinical indications to include treatment of benign pigmented lesions, photodamage, melasma, and scar revision. In this systematic review, evidence-based recommendations are developed for the use of picosecond laser in dermatology. Read More

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http://dx.doi.org/10.1002/lsm.23244DOI Listing
April 2020
2.619 Impact Factor

Use of a Picosecond Alexandrite Laser for Treating Acquired Bilateral Nevus of Ota-Like Macules in Chinese Patients.

Lasers Surg Med 2020 Apr 13. Epub 2020 Apr 13.

Department of Cosmetic Laser Surgery, Hospital for Skin Disease and Institute of Dermatology, Peking Union Medical College (PUMC) & Chinese Academy of Medical Sciences (CAMS), Jiangwangmiao Street 12, Xuanwu District, Nanjing, 210042, Jiangsu, China.

Background And Objectives: Acquired bilateral nevus of Ota-like macules (ABNOM) is common among the Chinese population. There have been few studies on the use of a picosecond alexandrite laser for the treatment of ABNOMs. The goal of this study was to evaluate the efficacy and safety of a 755 nm picosecond alexandrite laser for the treatment of ABNOMs. Read More

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http://dx.doi.org/10.1002/lsm.23245DOI Listing

A Corrective Cosmetic Improves the Quality of Life and Skin Quality of Subjects with Facial Blemishes Caused by Skin Disorders.

Clin Cosmet Investig Dermatol 2020 30;13:253-257. Epub 2020 Mar 30.

Third Faculty of Medicine, Charles University and Kralovske Vinohrady University Hospital, Department of Dermatovenereology, Prague, Czech Republic.

Background: Facial blemishes resulting from skin disorders have a significant effect on the patient's self-esteem and impact quality of life (QOL).

Aim: To assess the impact of a corrective cosmetic (CC) on QOL on top of skin quality parameters.

Methods: An international observational study was conducted on subjects with visible facial flaws that would benefit from a corrective cosmetic. Read More

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http://dx.doi.org/10.2147/CCID.S240437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125304PMC

Epilepsy in isolated parenchymal neurocutaneous melanosis: A systematic review.

Epilepsy Behav 2020 Jun 6;107:107061. Epub 2020 Apr 6.

Section of Pediatrics, Department of Medical Sciences, University of Ferrara, University Hospital Arcispedale Sant'Anna, Ferrara, Italy.

Purpose: Neurocutaneous melanosis (NCM) is a rare congenital syndrome characterized by giant melanocytic cutaneous nevi and melanosis within the central nervous system (CNS), often sparing leptomeninges and concentrated in the brain parenchyma. Epilepsy and neurodevelopmental abnormalities are the only complications reported in children with isolated parenchymal melanosis. A minority of patients experience drug-resistant epilepsy, and up to now, no predictors of epilepsy prognosis have been identified. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107061DOI Listing

Photoaging Reversibility in Asian Patients With Melasma Treated Using Picosecond Lasers With Diffractive Lens Array: A 1-Year Prospective Observational Cohort Study.

Dermatol Surg 2020 Apr 6. Epub 2020 Apr 6.

Department of Cosmeceutics, Graduate Institute of Cosmeceutics, China Medical University, Taichung, Taiwan (R.O.C.).

Background: Picosecond lasers appear to be effective and safe in treating pigmentation and photoaging disorders through laser-induced optical breakdown.

Objective: To analyze the feasibility of photorejuvenation using picosecond lasers with diffractive lens array (DLA) in patients with melasma.

Methods: Ten Asian (N = 10) women with melasma and Fitzpatrick skin Type IV were enrolled and treated using 755-nm picosecond alexandrite lasers with DLA. Read More

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http://dx.doi.org/10.1097/DSS.0000000000002405DOI Listing
April 2020
2.109 Impact Factor

[A woman with a skin lesion suspected for melanoma].

Ned Tijdschr Geneeskd 2020 Feb 27;164. Epub 2020 Feb 27.

Antoni van Leeuwenhoekziekenhuis, afd. Dermatologie, Amsterdam.

We saw a 59-year-old patient who was treated with dabrafenib and trametinib because of metastatic melanoma. She had an asymptomatic, black-blue macula in the excision scar. Histopathology showed tumoral melanosis. Read More

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February 2020

Emerging role of dermal compartment in skin pigmentation: comprehensive review.

J Eur Acad Dermatol Venereol 2020 Apr 3. Epub 2020 Apr 3.

Department of Dermatology, PGIMER, Chandigarh, India.

The variations in human skin colour mainly occur due to differences in the distribution of melanin pigment throughout the body, synthesized by epidermal melanocytes which are further taken up by keratinocytes present in epidermis. Recently, it has been discovered that besides these cells, dermis derived fibroblast factors also play a prominent role in regulating skin pigmentation. There exists a signal crosstalk between epidermal melanocytes, keratinocytes and dermal fibroblasts and any impairment in these signalling pathways may give rise to pigmentary disorders. Read More

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http://dx.doi.org/10.1111/jdv.16404DOI Listing
April 2020
2.826 Impact Factor

Recent Advances in Studies of Skin Color and Skin Cancer.

Yale J Biol Med 2020 03 27;93(1):69-80. Epub 2020 Mar 27.

Department of Dermatology and The Yale Cancer Center, Yale School of Medicine, New Haven, CT.

The relationship between skin color and skin cancer is well established: the less melanin in one's skin the greater the risk for developing skin cancer. This review is in two parts. First, we summarize the current understanding of the cutaneous pigmentary system and trace melanin from its synthesis in the pigment cell melanosomes through its transfer to keratinocytes. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087065PMC

Efficacy of 577 nm pro-yellow laser in the treatment of melasma: a prospective split-face study.

J Cosmet Laser Ther 2020 Feb 27;22(2):107-110. Epub 2020 Mar 27.

Specialist in Dermatology Department, Abnob Hospital, Assiut, Egypt.

We aimed to study the effectiveness of 577 nm pro-yellow laser in the treatment of melasma. A total of 82 patients with melasma were included in this comparative study. A detailed medical history, examination, and calculation of Melasma Area and Severity Index were done for all patients. Read More

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http://dx.doi.org/10.1080/14764172.2020.1744661DOI Listing
February 2020

Safflospermidines from the bee pollen of L. exhibit a higher antityrosinase activity than kojic acid.

Heliyon 2020 Mar 23;6(3):e03638. Epub 2020 Mar 23.

Department of Biology, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Bangkok 10330, Thailand.

Background: Ozone deterioration in the atmosphere has become a severe problem causing overexposure of ultraviolet light, which results in humans in melanin overproduction and can lead to many diseases, such as skin cancer and melasma, as well as undesirable esthetic appearances, such as freckles and hyperpigmentation. Although many compounds inhibit melanin overproduction, some of them are cytotoxic, unstable, and can cause skin irritation. Thus, searching for new natural compounds with antityrosinase activity and less/no side effects is still required. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090343PMC

Epidemiological features of rosacea in Changsha, China: A population-based, cross-sectional study.

J Dermatol 2020 May 24;47(5):497-502. Epub 2020 Mar 24.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Rosacea is a common chronic skin disorder of unknown etiology. While population prevalence rates range 0.2-22% in Europe and North America, prevalence in China is currently undetermined. Read More

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http://dx.doi.org/10.1111/1346-8138.15301DOI Listing

Invited Discussion on: A Meta-analysis-Based Assessment of Intense Pulsed Light for Treatment of Melasma.

Aesthetic Plast Surg 2020 Jun 20;44(3):953-954. Epub 2020 Mar 20.

Sanctuary Plastic Surgery, 4800 N. Federal Highway, Suite c101, Boca Raton, FL, 33431, USA.

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http://dx.doi.org/10.1007/s00266-020-01671-9DOI Listing