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    Keratinocyte Sonic Hedgehog Up-regulation Drives the Development of Giant Congenital Nevi via Paracrine Endothelin-1 Secretion.
    J Invest Dermatol 2017 Nov 11. Epub 2017 Nov 11.
    Drug Discovery Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. Electronic address:
    Giant congenital nevi are associated with clinical complications such as neurocutaneous melanosis and melanoma. Virtually nothing is known about why some individuals develop these lesions. We previously identified the sonic hedgehog (Shh) pathway regulator Cdon as a candidate nevus modifier gene. Read More

    Evaluation of the serum zinc level in adult patients with melasma: Is there a relationship with serum zinc deficiency and melasma?
    J Cosmet Dermatol 2017 Nov 12. Epub 2017 Nov 12.
    Ardebil University of Medical Sciences, Ardebil, Iran.
    Background: Melasma is a common acquired hypermelanosis of sun-exposed skin, particularly on the face, which presents as symmetric, light- to gray-brown-colored macules and patches. There are several studies of serum zinc levels in cutaneous disorders. So far, no studies have been carried out to assess the serum zinc level in patients with melasma. Read More

    The Asian Problem of Frequent Laser Toning for Melasma.
    J Clin Aesthet Dermatol 2017 Jul 1;10(7):40-42. Epub 2017 Jul 1.
    Dr. Tian is with Singapore General Hospital in Singapore.
    In recent years, laser toning or laser facial to treat melasma has become increasingly popular in Asia. It is common to see patients undergoing lasers three times a week, or even daily. This is part of a growing trend and is sometimes recommended in the user manuals from laser manufacturers. Read More

    Melanosis coli: Harmless pigmentation? A case-control retrospective study of 657 cases.
    PLoS One 2017 31;12(10):e0186668. Epub 2017 Oct 31.
    Department of Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
    Backgrounds And Aims: The association of melanosis coli with the development of colorectal polyps remains uncertain.

    Methods: From a total of 18263 patients who had received colonoscopy in our hospital, 219 with melanosis coli cases and 438 controls matched by age and sex (at 1:2 ratio) were included in this study. The association of incidence, number, location, and pathology of colorectal neoplasm with grades and distribution of melanosis coli were analyzed. Read More

    Conjunctival changes in different clinical variants of early pseudoexfoliation.
    Int Ophthalmol 2017 Oct 30. Epub 2017 Oct 30.
    Glaucoma Diagnostic Service, LV Prasad Eye Institute, Patia, Bhubaneswar, Odisha, 751024, India.
    Purpose: To evaluate the conjunctival signs in different forms of pseudoexfoliation (PXF) syndrome to identify signs predicting early forms of the disease.

    Methods: This observational study included patients with newly diagnosed PXF screened in the outpatient department of glaucoma services. Slit lamp photographs were captured in low and high magnification after full dilatation, and details like melanotic pigmentation, vascularity and tortuosity of vessels, scarring if any, presence of pterygium and actinic changes along with basal Schirmer's test were analysed. Read More

    Benefits of Urologic-Dermatologic Consultations for the Diagnosis of Cutaneous Penile Lesions: A Prospective Study.
    Clin Genitourin Cancer 2017 Oct 5. Epub 2017 Oct 5.
    Department of Urology, Angers University Hospital, Angers, France.
    Introduction: We evaluated the benefits of a specialized consultation created in 2014 for cutaneous penile lesions.

    Materials And Methods: We performed a descriptive prospective study evaluating all patients sent for a monthly urologic-dermatologic consultation at a French university hospital from September 2014 to September 2015 for cutaneous penile lesions. All patients evaluated were included. Read More

    Acupuncture and Cutaneous Medicine: Is It Effective?
    Med Acupunct 2017 Oct;29(5):269-275
    Medical Acupuncture of Chester County, West Chester, PA.
    Background: In China, acupuncture has been used as a form of medical therapy for more than 2500 years. It is a part of traditional medical practice and is used to treat the entire spectrum of human and veterinary disease. Although dermatologic disease has received much less attention in worldwide acupuncture research than pain and musculoskeletal conditions, there is a growing body of evidence suggesting acupuncture's usefulness in this area. Read More

    Light-emitting diode 585nm photomodulation inhibiting melanin synthesis and inducing autophagy in human melanocytes.
    J Dermatol Sci 2017 Oct 11. Epub 2017 Oct 11.
    Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, PR China. Electronic address:
    Background: Melasma is a common hyperpigmentation skin disease on face. Light-emitting diode (LED) photomodulation (585nm) is reported to be effective for the treatment of melasma. However, whether and how LED photomodulation would influence melanogenesis of human epidermal melanocytes (HEMs) is unknown. Read More

    Considerations When Treating Cosmetic Concerns in Men of Color.
    Dermatol Surg 2017 Nov;43 Suppl 2:S140-S150
    *Department of Dermatology, The George Washington Medical Faculty Associates, Washington, DC; †Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC; ‡Department of Dermatology, Georgetown University School of Medicine, Washington, DC; §Division of Dermatology, University of California, Los Angeles, California.
    Background: Men of color include a diverse population encompassing individuals with Fitzpatrick skin Types IV through VI. Yet, there is a paucity of data describing the cosmetic concerns of this population.

    Objective: To review the basic science of advantages and disadvantages of skin of color and pathophysiology, incidence, and treatment of disorders of cosmetic concern in men of color. Read More

    Q-switched Nd: YAG laser alone or with modified Jessner chemical peeling for treatment of mixed melasma in dark skin types: A comparative clinical, histopathological, and immunohistochemical study.
    J Cosmet Dermatol 2017 Oct 22. Epub 2017 Oct 22.
    Dermatology and leprosy Hospital, Al-Minya, Egypt.
    Backgrounds: Treatment of mixed melasma remains challenging. Promising results have been achieved with low-fluence 1064-nm Q-switched Nd-YAG laser; however, multiple sessions are necessary with occurrence of complications especially in dark skin types. So, combination methods may be recommended. Read More

    Morphologic and Elemental Analysis of Primary Melanosis of the Dentate Nucleus: Review and Correlation With Neuromelanin.
    J Neuropathol Exp Neurol 2017 Nov;76(11):949-956
    Department of Pathology, School of Medicine, University of South Florida-Morsani, Tampa, Florida; Medical College of Georgia, Augusta University, Augusta, Georgia.
    Primary melanosis of the dentate nucleus is a rarely described entity with neither known cause nor definitive clinicopathologic correlation. We revisit this previously reported phenomenon by presenting one such case with a review of the pathology as well as additional investigations including elemental analysis by energy-dispersive X-ray, immunohistochemistry and electron microscopy. The lesion presented macroscopically as a sharply defined, black pigmentation that was restricted to the dentate nucleus of the cerebellum. Read More

    Dermoscopy and patch testing in patients with lichen planus pigmentosus on face: A cross-sectional observational study in fifty Indian patients.
    Indian J Dermatol Venereol Leprol 2017 Nov-Dec;83(6):656-662
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
    Background: Lichen planus pigmentosus (LPP) is a common cause of facial melanosis in the dark-skinned population. At present, information on dermoscopy and patch testing in LPP is limited.

    Objectives: To describe dermoscopic findings and study the role of patch testing in patients with LPP on the face. Read More

    Comparing the efficacy of topical hydroquinone 2% versus intradermal tranexamic acid microinjections in treating melasma: a split-face controlled trial.
    J Dermatolog Treat 2017 Nov 9:1-6. Epub 2017 Nov 9.
    c Student Research Committee , Shiraz University of Medical Sciences , Shiraz , Iran.
    Introduction: Melasma is a benign, acquired and chronic hypermelanosis. Topical hydroquinone (HQ) is a conventional choice to treat melasma. Tranexamic acid (TA) is a relatively new brightening agent that interferes with keratinocyte-melanocyte interactions. Read More

    Effects of fractional picosecond 1,064 nm laser for the treatment of dermal and mixed type melasma.
    J Cosmet Laser Ther 2017 Oct 11. Epub 2017 Oct 11.
    a School of Antiaging and Regenerative Medicine , Mae Fah Luang University , Thailand.
    Background: Picosecond laser is a novel modality for pigmented skin disorders with extremely short pulse duration. Little is known about the effects of picosecond laser in melasma.

    Objective: This study aimed to investigate the efficacy of fractional picosecond 1,064 nm laser in melasma treatment. Read More

    Recent advances and perspectives in liposomes for cutaneous drug delivery.
    Curr Med Chem 2017 Oct 9. Epub 2017 Oct 9.
    Faculty of Pharmaceutical Sciences -University of Campinas (UNICAMP). Brazil.
    The cutaneous route is attractive for the delivery of drugs in the treatment of a wide variety of diseases. However the stratum corneum (SC) is an effective barrier that hampers skin penetration. Within this context, liposomes emerge as a potential carrier for improving topical delivery of therapeutic agents. Read More

    Randomized, placebo-controlled, double-blind study of oral tranexamic acid in the treatment of moderate to severe melasma.
    J Am Acad Dermatol 2017 Oct 4. Epub 2017 Oct 4.
    Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:
    Background: Melasma is a common pigmentary disorder that is often difficult to treat. Tranexamic acid (TA) has emerged as a promising treatment for melasma; however, few controlled studies exist.

    Objective: To determine the efficacy of oral TA in patients with moderate to severe melasma METHODS: Patients with moderate to severe melasma were treated with 250 mg of TA or placebo capsules twice daily for 3 months and sunscreen followed by 3 months of treatment with sunscreen only. Read More

    A 23-Nucleotide Deletion in STK11 Gene Causes Peutz-Jeghers Syndrome and Malignancy in a Chinese Patient Without a Positive Family History.
    Dig Dis Sci 2017 Nov 6;62(11):3014-3020. Epub 2017 Oct 6.
    Department of Medical Genetics, Naval Medical University, 800 Xiangyin Rd., Shanghai, 200433, China.
    Background And Aims: Peutz-Jeghers syndrome (PJS) is an autosomal-dominant genetic disease caused by mutations in the tumor suppressor gene, STK11, which is characterized by gastrointestinal hamartomas, melanin spots on the lips and the extremities, and an increased risk of developing both gastrointestinal and extraintestinal malignancies.

    Methods And Results: We treated a PJS patient without a positive family history, who possessed typical clinical manifestations including polyp canceration. In order to explore the genotype of this patient, blood samples were collected from all the available family members. Read More

    Nonablative Fractional Laser Resurfacing in Skin of Color: Evidence-based Review.
    J Clin Aesthet Dermatol 2017 Jun 1;10(6):51-67. Epub 2017 Jun 1.
    Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
    Background: Nonablative laser resurfacing represents one of the major advances in procedural dermatology over the past decade. However, its use in darker skin types is limited by safety concerns and a relative lack of available data. Aim: To provide evidence-based recommendations for the use of fractional lasers in darker skin types. Read More

    Urothelial melanosis of the bladder.
    Can J Urol 2017 Oct;24(5):9035-9037
    Division of Urology, University of Connecticut Health Center, Farmington, Connecticut, USA.
    Urothelial melanosis is a rare finding characterized by abnormal pigmentation noted on cystoscopic evaluation and histologically defined by melanin deposition in the urothelium. Although generally considered benign, few cases of urothelial melanosis have been reported in the literature and the risk of recurrence or progression remains largely unknown. Four cases associated with urothelial cell carcinoma have been previously described. Read More

    Dermatoscopic evaluation and histopathological correlation of acquired dermal macular hyperpigmentation.
    Int J Dermatol 2017 Dec 3;56(12):1395-1399. Epub 2017 Oct 3.
    Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background: Acquired dermal macular hyperpigmentation (ADMH) is a hypernym encompassing Riehl's melanosis, lichen planus pigmentosus, and ashy dermatoses that show significant clinicopathological overlap. We sought to describe the dermatoscopic features of ADMH and correlate them with histopathological findings.

    Methods: This was a prospective observational study performed in two phases. Read More

    Surgical amniotic membrane transplantation after conjunctival and limbal tumor excision.
    Arq Bras Oftalmol 2017 Jul-Aug;80(4):242-246
    Department of Ophthalmology, Ankara Training and Research Hospital, Ankara, Turkey.
    Purpose:: To evaluate the clinical results of patients treated by amniotic membrane transplantation (AMT) following excision of conjunctival and limbal tumors.

    Methods:: A total of 14 eyes of 14 patients who underwent AMT after total lesion-free tumor excision and perilesional cryotherapy were evaluated.

    Results:: The excised tumors comprised 7 conjunctival intraepithelial neoplasia, 5 conjunctival nevus, 1 primary acquired melanosis, and 1 squamous cell carcinoma. Read More

    The clinicoaetiological, hormonal and histopathological characteristics of melasma in men.
    Clin Exp Dermatol 2017 Sep 22. Epub 2017 Sep 22.
    Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background: Melasma is relatively uncommon in males, and there is a paucity of data on male melasma, including its clinical pattern, triggering factors, endocrine profile and histopathological findings.

    Aim: To characterize the clinical findings and aetiological factors, including hormonal and histopathological features, of male melasma.

    Methods: Male patients with melasma and age- and sex-matched healthy controls (HCs) were recruited. Read More

    Penile Melanosis Associated with Lichen Sclerosus et Atrophicus: First Description in the Medical Literature.
    Open Access Maced J Med Sci 2017 Aug 10;5(5):692-693. Epub 2017 Aug 10.
    Medical Institute of Ministry of Interior (MVR), Department of Dermatology and Dermatologic Surgery, Generel Skobelev 79, 1606 Sofia, Bulgaria.
    We present a 74-year-old male patient with 3-years history of visible discoloration of the glans penis, without subjective complaints. Histopathological examination after incision biopsy revealed a moderate increase in the number of melanocytes in the basal layer with irregular distribution, without melanocytic nests, melanophages in the superficial dermis, and subepidermal sclerosus. No cytologic atypia of melanocytes was detectable. Read More

    Combination of Q-Switched Nd:YAG and Fractional Erbium:YAG Lasers in Treatment of Melasma: A Randomized Controlled Clinical Trial.
    J Lasers Med Sci 2017 8;8(1):1-6. Epub 2017 Jan 8.
    Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Introduction: Ablative and nonablative lasers have been used to treat melasma. We aimed to assess and compare the combining Q-switched Nd:YAG laser (QSNYL) and fractional erbium:YAG laser (FEYL) with QSNYL alone in treatment of melasma. Methods: This randomized controlled clinical trial was performed in our Research Center during 2013-2014. Read More

    Recent development of signaling pathways inhibitors of melanogenesis.
    Cell Signal 2017 Dec 12;40:99-115. Epub 2017 Sep 12.
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National, University, Daejeon 34134, Republic of Korea.
    Human skin, eye and hair color rely on the production of melanin, depending on its quantity, quality, and distribution, Melanin plays a monumental role in protecting the skin against the harmful effect of ultraviolet radiation and oxidative stress from various environmental pollutants. However, an excessive production of melanin causes serious dermatological problems such as freckles, solar lentigo (age spots), melasma, as well as cancer. Hence, the regulation of melanin production is important for controlling the hyper-pigmentation. Read More

    Efficacy and safety of a novel picosecond laser using combination of 1 064 and 595 nm on patients with melasma: A prospective, randomized, multicenter, split-face, 2% hydroquinone cream-controlled clinical trial.
    Lasers Surg Med 2017 Sep 14. Epub 2017 Sep 14.
    Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    Background And Objectives: Melasma is a common acquired, chronic hypermelanosis and still remains a therapeutic challenge. The low-fluence 1 064 nm Q-switched Nd:YAG laser is the most widely used for the treatment of moderate to severe melasma in Asia. Recently, the picosecond laser has been introduced for various pigmentary disorders such as melasma. Read More

    Outcome Analyses of 15,189 Screenings Via Colonoscopy.
    Surg Laparosc Endosc Percutan Tech 2017 Oct;27(5):400-403
    Departments of *Gastroenterology †Trauma and Orthopaedics, The Second Hospital of Shandong University, Shandong Province, Peoples Republic of China.
    Purpose: This study investigated the detection rates of common colorectal diseases during colonoscopy procedures to provide reference for clinical diagnoses in China.

    Methods: A total of 15,189 participants, who underwent total colonoscopy, were studied. We analyzed the detection rates of common colorectal diseases in different sex, age, and decade groups. Read More

    Chemical Peels: Indications and Special Considerations for the Male Patient.
    Dermatol Surg 2017 Nov;43 Suppl 2:S163-S173
    *Division of Dermatology, Loyola University Medical Center, Maywood, Illinois; †Division of Dermatology & Dermatologic Surgery, Scripps Clinic, La Jolla, California.
    Background: Chemical peels are a mainstay of aesthetic medicine and an increasingly popular cosmetic procedure performed in men.

    Objective: To review the indications for chemical peels with an emphasis on performing this procedure in male patients.

    Materials And Methods: Review of the English PubMed/MEDLINE literature and specialty texts in cosmetic dermatology, oculoplastic, and facial aesthetic surgery regarding sex-specific use of chemical peels in men. Read More

    [Current Therapies in Superficial Malignant Tumors].
    Klin Monbl Augenheilkd 2017 Sep 12. Epub 2017 Sep 12.
    Zentrum für Augenheilkunde, Universitätsklinikum Essen, Essen.
    This article is a review of diagnostic and therapeutic possibilities in common epibulbar malignant tumors, such as basal cell carcinoma, conjunctival lymphoma, squamous cell carcinoma and conjunctival melanoma. Most importantly, for every tumor patient there is a detailed anamnesis, split lamp examination and photo documentation. Further regular controls after therapy are required due to the risk of recurrences. Read More

    Hypothyroidism in the "Arnolfini Portrait" (1434) by Jan Van Eyck (1390-1441).
    J Endocrinol Invest 2017 Sep 9. Epub 2017 Sep 9.
    The Department of Surgery and Cancer, Imperial College London, 10th Floor Queen Elizabeth the Queen Mother (QEQM) Building, St Mary's Hospital, Praed Street, London, W2 1NY, UK.
    Background: The Arnolfini portrait painted by Jan van Eyck in 1434 remains one of the most puzzling yet alluring paintings of prerenaissance western art.

    Purpose: The painting is renowned for its exactitude in brush strokes, textures and the distinctive morphology of the main character Arnolfini. The nature of these requires pathological consideration. Read More

    Systemic BRAF/MEK Inhibitors as a Potential Treatment Option in Metastatic Conjunctival Melanoma.
    Ocul Oncol Pathol 2017 Jul 8;3(2):133-141. Epub 2016 Dec 8.
    Department of Ophthalmology, University of Cologne, Cologne, Germany.
    Aim: In this review, we outline similarities between conjunctival and skin melanoma as well as the effectiveness of combined BRAF/MEK inhibition in melanoma, and discuss the applicability of these agents in conjunctival melanoma.

    Methods: The study provides a PubMed literature review.

    Results: Conjunctival melanoma and skin melanoma are genetically and phenotypically related. Read More

    Oral melanoma and other pigmentations: when to biopsy?
    J Eur Acad Dermatol Venereol 2017 Sep 1. Epub 2017 Sep 1.
    Dermatology, Department of Experimental Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
    Oral pigmentations (OPs) are often neglected, although a meticulous examination of the oral cavity is important not only in the diagnosis of oral melanoma, but also for the detection of important clinical findings that may indicate the presence of a systemic disease. OPs may be classified into two major groups on the basis of their clinical appearance: focal and diffuse pigmentations, even though this distinction may not appear so limpid in some cases. The former include amalgam tattoo, melanocytic nevi, melanoacanthoma and melanosis, while the latter include physiological/racial pigmentations, smoker's melanosis, drug-induced hyperpigmentations, postinflammatory hyperpigmentations and OPs associated with systemic diseases. Read More

    Review of applications of microneedling in dermatology.
    Clin Cosmet Investig Dermatol 2017 8;10:289-298. Epub 2017 Aug 8.
    George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
    Microneedling (MN) is a novel therapeutic modality in dermatology. Through physical trauma from needle penetration, MN induces a wound healing cascade with minimal damage to the epidermis. This allows for enhancement in the absorption of mainstay topical therapies across the thick stratum corneum. Read More

    Black peel in facial dermatoses.
    J Cosmet Dermatol 2017 Aug 22. Epub 2017 Aug 22.
    Dermatology department, Academia title for health professional (QU affiliation), Libya, Tripoli.
    Background: Melasma (facial dermatoses) is an acquired chronic disorder of hyperpigmentation over sun exposed parts and continues to be a therapeutic challenge due to the presence of melanin at varying depths in the epidermis and dermis, and many researchers are working hard to find a solution. The main culprit to remain is direct sun exposure, with other factors like drugs, genetic predisposition, thyroid abnormalities, pregnancy, phototoxic and photoallergic cosmetics. Melasma continues to have a remarkable impact on the well-being of affected patients causing deep psychological and social anguish, and with the expansion of cosmetic dermatology globally, treatments that are successful against skin diseases and boost beauty without prolonged recovery periods, or exposing patients to the risks of surgery, are increasingly recognised and acknowledged. Read More

    Laser treatment of medical skin disease in women.
    Int J Womens Dermatol 2017 Sep 21;3(3):131-139. Epub 2017 Jul 21.
    Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT.
    Laser treatment is a relatively new and increasingly popular modality for the treatment of many dermatologic conditions. A number of conditions that predominantly occur in women and that have a paucity of effective treatments include rosacea, connective tissue disease, melasma, nevus of Ota, lichen sclerosus (LS), notalgia paresthetica and macular amyloidosis, and syringomas. Laser therapy is an important option for the treatment of patients with these conditions. Read More

    Protocatechuic Acid from Pear Inhibits Melanogenesis in Melanoma Cells.
    Int J Mol Sci 2017 Aug 21;18(8). Epub 2017 Aug 21.
    Department of Animal Science, Chonnam National University, Gwangju 61186, Korea.
    Despite the critical role of melanin in the protection of skin against UV radiation, excess production of melanin can lead to hyperpigmentation and skin cancer. Pear fruits are often used in traditional medicine for the treatment of melasma; therefore, we investigated the effects of pear extract (PE) and its component, protocatechuic acid (PCA), on melanogenesis in mouse melanoma cells. We found that PE and PCA significantly suppressed melanin content and cellular tyrosinase activity through a decrease in the expression of melanogenic enzymes and microphthalmia-associated transcription factor (Mitf) in α-melanocyte stimulating hormone-stimulated mouse melanoma cells. Read More

    Peppered and rare - Gastric and Duodenal Pseudomelanosis: A case series.
    Pak J Med Sci 2017 May-Jun;33(3):757-760
    Michael Demyen, Department of Gastroenterology and Hepatology, Rutgers University, Newark, NJ, USA.
    Upper Gastrointestinal (GI) pseudomelanosis is an uncommon entity characterized by endoscopic visualization of speckled dark mucosal pigmentation. While described in the rectum and colon, 'melanosis' or more aptly 'pseudomelanosis' is rare in the duodenum and exceedingly rare in the stomach. Five cases of pseudomelanosis were encountered at our department. Read More

    Microneedling: A Review and Practical Guide.
    Dermatol Surg 2017 Aug 7. Epub 2017 Aug 7.
    *Washington Institute of Dermatologic Laser Surgery, Washington, District of Columbia; †Department of Dermatology, St. Joseph Mercy Hospital, Ann Arbor, Michigan.
    Background: Microneedling is a relatively new treatment option in dermatology and has been touted for a broad range of applications including skin rejuvenation, acne scarring, rhytides, surgical scars, dyschromia, melasma, enlarged pores, and transdermal drug delivery. The significant increase in minimally invasive procedures that has been reported over the past several years suggest that microneedling may occupy a specific niche for patients who desire measurable clinical results from treatments with little to no recovery.

    Objective: To review the published medical literature relating to microneedling in dermatology and provide a practical guide for its use in clinical practice. Read More

    Involvement of Transient Receptor Potential Cation Channel Member A1 activation in the irritation and pain response elicited by skin-lightening reagent hydroquinone.
    Sci Rep 2017 Aug 8;7(1):7532. Epub 2017 Aug 8.
    Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
    Hydroquinone (HQ) is one of the most frequently used and effective skin-lightening products to treat skin hyperpigmentation disorders, including postinflammatory hyperpigmentation, melasma and solar lentigines. HQ is also widely used in cosmetic products for skin whitening. However, HQ treatment can evoke substantial skin irritation, a side effect that remains poorly understood. Read More

    A Retrospective Study, an Initial Lesion of Primary Malignant Melanoma of the Esophagus Revealed by Endoscopy.
    Intern Med 2017 Aug 1;56(16):2133-2137. Epub 2017 Aug 1.
    Department of Gastroenterology, Akita University Graduate School of Medicine, Japan.
    A 66-year-old man presented to his previous physician with epigastric discomfort in 2014. He was then referred to our hospital due to suspected primary malignant melanoma of the esophagus (PMME). A biopsy showed atypical cells containing melanin granules. Read More

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