9,221 results match your criteria Melasma


Effects of moringa leaves () extraction on quality changes and melanosis of giant freshwater prawn () during chilled storage.

Ital J Food Saf 2018 Sep 26;7(3):6846. Epub 2018 Sep 26.

Institute of Tropical Aquaculture.

An aqueous extraction of moringa () leaves were prepared as the edible coats for keeping the quality of the giant freshwater prawn (). In addition, the antioxidant properties and activity; total phenolic content (TPC), total flavonoid contents (TFC), free radical scavenging activity (DPPH), and ferric reducing antioxidant power (FRAP) of moringa leaves were also determined. The phenolic compounds and antioxidant properties in the moringa leaves are low; 16. Read More

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September 2018

Significant therapeutic response to cysteamine cream in a melasma patient resistant to Kligman's formula.

J Cosmet Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.

L-Cysteamine is a biological antioxidant produced during the coenzyme A metabolism cycle and is naturally present in all mammalian cells. The efficacy of topical cysteamine for the treatment of melasma has been recently shown in two double-blind, randomized, and placebo-controlled clinical trials. Herein, we report a 44-year-old patient with melasma resistant to Kligman's formula (Pigmanorm cream), who was successfully treated with topical cysteamine as a new depigmenting agent. Read More

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December 2018
1 Read

Evaluation of oral tranexamic acid in the treatment of melasma.

J Cosmet Dermatol 2018 Dec 9. Epub 2018 Dec 9.

Universidade de Mogi das Cruzes, Dermatology, Mogi das Cruzes, Brazil.

Background: Melasma is an acquired, chronic, recurrent hypermelanosis that occurs exclusively in areas exposed to the sun. Its treatment can be very challenging. Tranexamic acid (TA) is an inhibitor of plasmin, and it is a synthetic derivative of the amino acid lysine that reversibly blocks binding sites on the plasminogen molecule, inhibiting the plasminogen activator from converting plasminogen to plasmin. Read More

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December 2018
2 Reads

Tranexamic Acid for Adults with Melasma: A Systematic Review and Meta-Analysis.

Biomed Res Int 2018 6;2018:1683414. Epub 2018 Nov 6.

Department of Plastic Surgery, Zhejiang Hospital, Hangzhou 310013, China.

Objective: Melasma is a highly prevalent, chronic, and pigmentary disorder. This systematic review aims to evaluate the efficacy and safety of tranexamic acid (TA) for the treatment of adults with melasma.

Methods: We independently searched 3 databases from beginning to 26 April, 2018. Read More

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November 2018

Acquired diffuse slate-grey facial dyspigmentation due to henna: an unrecognized cause of pigment contact dermatitis in Korean patients.

Eur J Dermatol 2018 Oct;28(5):644-648

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Henna is a vegetable hair dye that can be used by individuals who are sensitized to oxidative dyes due to low allergenicity. The reported incidence of slate-grey facial dyspigmentation following the use of henna hair dye is extremely rare. This study aimed to identify the clinical, dermoscopic, and histopathological features of slate-grey facial dyspigmentation following the use of henna hair dye in Korean patients. Read More

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October 2018

In vivo multiphoton microscopy imaging of melasma.

Pigment Cell Melanoma Res 2018 Dec 1. Epub 2018 Dec 1.

Unilever R&D, 40 Merritt Blvd, Trumbull, CT, 06611.

Melasma is a skin disorder characterized by hyperpigmented patches due to increased melanin production and deposition. In this pilot study we evaluate the potential of multiphoton microscopy (MPM) to characterize non-invasively the melanin content, location, and distribution in melasma and assess the elastosis severity. We employed a clinical MPM tomograph to image in-vivo morphological features in melasma lesions and adjacent normal skin in 12 patients. Read More

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December 2018

Histopathological comparison of lesional and perilesional skin in melasma: A cross-sectional analysis.

Indian J Dermatol Venereol Leprol 2018 Dec 5. Epub 2018 Dec 5.

Consultant Dermatologist and Epidemiologist, Mumbai, Maharashtra, India.

Background: Melasma is a common acquired hyperpigmentary disorder of the sun exposed skin, especially the face. The pathogenesis is unclear but interplay between genetic factors, hormones and ultraviolet radiation is important. We have evaluated the histological characteristics of melasma and compared the findings with adjacent normal skin. Read More

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December 2018
3 Reads

Bilateral Iris Mammillations in Amblyopic Eyes without Oculodermal Melanocytosis or Neurofibromatosis.

Case Rep Ophthalmol Med 2018 29;2018:2534042. Epub 2018 Oct 29.

Department of Ophthalmology, Teikyo University School of Medicine, Tokyo 173-8605, Japan.

Purpose: Iris mammillations are related to oculodermal melanosis and iris nevi. We report a rare case of bilateral simple iris mammillations without ocular melanosis or systemic neuronal disorders.

Case Report: A healthy 10-year-old Japanese girl was found incidentally to have bilateral iris mammillations while being treated for amblyopia. Read More

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October 2018
1 Read

Assessing skin disease and associated health-related quality of life in a rural Lao community.

BMC Dermatol 2018 Dec 4;18(1):11. Epub 2018 Dec 4.

Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology laboratory, Mahosot Hospital, Vientiane, Laos.

Background: Skin diseases are common and often have an impact on an individual's health-related quality of life. In rural communities where access to healthcare may be limited and individuals rely on farming for food and income, the impact of skin diseases may be greater. The objectives for this study were to perform an assessment of skin disease prevalence in a rural village in Laos and assess the associated impact of any skin disease found using the Dermatology Life Quality Index (DLQI). Read More

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December 2018
3 Reads

Melasma Associated with Periodontitis, Anemia, and Vitamin D Abnormalities: A Chance Occurrence or a Syndrome.

J Contemp Dent Pract 2018 Oct 1;19(10):1254-1259. Epub 2018 Oct 1.

Department of Oral Medicine and Radiology, Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre Hyderabad, Telangana, India.

Aim: To correlate the possible association between melasma, periodontitis, vitamin D abnormalities, and anemia.

Materials And Methods: A total of 192 subjects, of either gender within the age group of 30 to 70 years were divided equally into two groups, group I (case group, patients with melasma) and group II (control group, patients without melasma). In all the subjects, anemia and periodontitis were checked clinically, along with biochemical evaluation of serum vitamin D levels and hemoglobin (Hb) percentage. Read More

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October 2018
1 Read

Oral tranexamic acid for the treatment of melasma.

Authors:
F R Ali

Clin Exp Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Dermatological Surgery and Laser Unit, Guy's Cancer Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.

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November 2018

Clinicopathologically problematic melanocytic tumors: a case-based review.

Dermatol Pract Concept 2018 Oct 31;8(4):306-313. Epub 2018 Oct 31.

Anatomic Pathology Unit, Hospital of Macerata, Italy.

Background: In spite of recent advances in the histopathological and molecular diagnosis of melanocytic neoplasms, a certain proportion of these lesions remain a daunting challenge for both the clinician and the pathologist.

Objectives: To emphasize the importance of close collaboration between clinicians and pathologists in case of problematic melanocytic lesions.

Patients: We report and discuss 5 problematic scenarios of melanocytic lesions, including tumoral melanosis, nevoid melanoma, lentiginous melanoma, spitzoid melanoma and BAPoma that may pose diagnostic difficulties in our practice. Read More

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October 2018
1 Read

Estrogen associated with UVB irradiation recapitulates the specific melanosome distribution observed in Caucasoid Melasma.

Br J Dermatol 2018 Nov 26. Epub 2018 Nov 26.

Department of Dermatology and Pediatric Dermatology, National Reference center for rare skin disorders, Hopital Saint André Bordeaux, France.

Melasma is characterized by light to dark brown macules that usually occur on the face. Melasma occurs in 10-15% of pregnant women and in 10-25% of women taking oral contraceptives. Fertile women are most likely to develop melasma. Read More

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November 2018

Melasma: update on management.

Semin Cutan Med Surg 2018 Dec;37(4):217-225

Dermatology and Laser Surgery Center, Houston, Texas, USA.

Melasma is a common, acquired, chronic cutaneous pigment disorder that is often difficult to treat and has a high recurrence rate. The goal of a melasma treatment regimen is to decrease pigment production and increase elimination. Topical tyrosinase inhibitors block melanin synthesis and thereby reduce pigment production. Read More

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December 2018
4 Reads

Aminoluciferin 4-hydroxyphenyl amide enables bioluminescence detection of endogenous tyrosinase.

Org Biomol Chem 2018 Dec;16(47):9197-9203

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China.

Tyrosinase, a copper-containing enzyme existing widely in plants, animals and microorganisms, usually serves as an important biomarker in melanoma, and is also related to hyperpigmentation of the skin, melasma, age spots and albinism. At present, only one bioluminescent probe has been applied to image tyrosinase in cells. Thus, it's of great significance to develop a new bioluminescent probe that can detect tyrosinase in living cells and in live animals. Read More

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December 2018
1 Read

Going Viral 2019: Zika, Chikungunya, and Dengue.

Dermatol Clin 2019 Jan;37(1):95-105

Department of Dermatology, University Hospital "Dr. José E. González", Universidad Autónoma de Nuevo León, Mitras Centro, Avenida Gonzalitos y Madero S/N, Monterrey 64460, Mexico.

Chikungunya and Zika virus infections are emerging diseases in the Americas, and dengue continues to be the most prevalent arthropod-borne virus in the world. These arbovirus diseases may spread by endemic transmission or as travel-related infections and have rapidly expanded their geographic distribution secondary to vector spread. All 3 share a similar clinical picture that includes a maculopapular rash. Read More

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January 2019
12 Reads

A melanosis coli associated with a large flat adenoma of the cecum.

Clin Res Hepatol Gastroenterol 2018 Nov 14. Epub 2018 Nov 14.

Department of pathology, university hospital, 37044 Tours cedex 9, France.

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November 2018

Neurocutaneous Melanosis with Leptomeningeal Melanoma Involving Supratentorium and Infratentorium.

Cureus 2018 Sep 10;10(9):e3275. Epub 2018 Sep 10.

Radiotherapy, Christian Medical College, Vellore, IND.

Neurocutaneous melanoma is a rare congenital syndrome associated with congenital melanocytic nevi with meningeal melanosis or melanoma. The disease is aggressive and has a high propensity for leptomeningeal metastases. We present the case history of a man with neurocutaneous melanoma managed with radical excision followed by hypofractionated adjuvant radiotherapy. Read More

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September 2018
1 Read

Assessment of combined fractional CO and tranexamic acid in melasma treatment.

Lasers Surg Med 2018 Nov 15. Epub 2018 Nov 15.

Dermatology Department, Cairo University Kasr Alainy Faculty of Medicine, Cairo, Egypt.

Background: Melasma continues to be a disease that is difficult to treat with no fully satisfactory results. The role of a fractional CO laser in its treatment is controversial. The addition of tranexamic acid (TXA) might be helpful. Read More

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November 2018
7 Reads

Evaluation of the Prevalence of Oral Mucosal Lesions in a Population of Eastern Coast of South India.

J Int Soc Prev Community Dent 2018 Sep-Oct;8(5):396-401. Epub 2018 Oct 8.

Department of Public Health Dentistry, Sibar Institute of Dental Sciences and Research, Guntur, Andhra Pradesh, India.

Objective/aim: The aim of this study is to measure the association between oral mucosal lesions (OMLs) and habit of tobacco and alcohol in the population of Guntur city, Andhra Pradesh, South India.

Material And Method: A cross-sectional study was conducted on 300 participants in Guntur city with the habit of tobacco and alcohol consumption in various forms who were selected by stratified cluster random sampling technique. Guntur city was divided into four zones, that is, North, East, South, and West; and two administrative wards were randomly selected from each zone as clusters. Read More

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October 2018
3 Reads

Melasma: Updates and Perspectives.

Exp Dermatol 2018 Nov 13. Epub 2018 Nov 13.

Seoul National University, College of Medicine, Seoul National University Bundang Hospital, Gyeonggi, Korea.

Management of melasma is highly challenging due to inconsistent treatment results and frequent relapses. However, recent studies revealed that melasma may not only be a disease of melanocytes, but also a photoaging skin disorder. Herein, we attempt to validate that melasma is indeed a photoaging disorder by presenting the histopathologic findings of melasma: solar elastosis, altered basement membrane, increased vascularization, and increased mast cell count. Read More

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November 2018
1 Read

Hyperpigmented Upper Eyelid: A Clue to the Diagnosis of Facial Lichen Planus Pigmentosus in a Patient with Frontal Fibrosing Alopecia.

Skin Appendage Disord 2018 Oct 4;4(4):335-338. Epub 2018 Apr 4.

Universidade Federal Fluminense, Niterói, Brazil.

Facial lichen planus pigmentosus (LPPig), a rare variant of classic lichen planus, was first described in patients with frontal fibrosing alopecia (FFA) by Dlova [Br J Dermatol 2013; 168: 439-442] in 2013. The diagnosis of facial LPPig is sometimes not easy, since clinical signs and histopathological features may frequently be confused with melasma or postinflammatory hyperpigmentation. We describe a case of a postmenopausal black woman diagnosed with FFA who presented with an identical brown-grayish pigmentation of the face and upper eyelids and typical dermoscopy analysis on both regions. Read More

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October 2018
6 Reads

Does using a high sun protection factor sunscreen on face, along with physical photoprotection advice, in patients with melasma, change serum vitamin D concentration in Indian conditions? A pragmatic pretest-posttest study.

Indian J Dermatol Venereol Leprol 2018 Nov 5. Epub 2018 Nov 5.

Department of Endocrinology and Metabolism, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Background: Use of sunscreens on the face is becoming popular, and patients with melasma are prescribed sunscreen for use on the face. Results of a few Western studies on the effect of sunscreen use on serum vitamin D concentration are not applicable to Indian conditions.

Aims: To examine the effect of use of a high sun protection factor (SPF 50+, PA++++) sunscreen on face in patients with melasma on serum concentration of 25-hydroxyvitamin D. Read More

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November 2018
1 Read

Cross-sectional study of psychiatric morbidity in patients with melasma.

Indian J Psychiatry 2018 Jul-Sep;60(3):324-328

Department of Dermatology, Smt. Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India.

Context: Patients with dermatological problems have higher prevalence of psychiatric illnesses than the general population. Melasma, hyperpigmentation of skin over sun-exposed areas, has bidirectional cause-effect relationship with depression and stress through psycho-neuro-endocrine pathways.

Aims: The aim of this study is to study the psychiatric morbidity and perceived stress in patients with melasma and statistically compare objective study parameters with those without melasma. Read More

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November 2018
8 Reads

A clinicoepidemiological study of topical corticosteroid misuse at a tertiary care centre.

J Dermatolog Treat 2018 Nov 3:1-20. Epub 2018 Nov 3.

a JNU Institute for Medical Sciences and Research Centre , Jaipur , Rajasthan , India.

Background: Misuse of topical corticosteroids (TCS) has become a burning issue in many countries across the globe. Non-prescriptional sale, lack of awareness and non availability of qualified dermatologist are some of the contributing factors.

Aim: To assess the clinicoepidemiological profile of patients misusing TCS and assess various factors contributing to it. Read More

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November 2018
2 Reads
1.760 Impact Factor

Extensive Vulvar Melanosis.

Actas Dermosifiliogr 2018 Oct 31. Epub 2018 Oct 31.

Departamento de Dermatología, Hospital Costa del Sol, Marbella, Málaga, España.

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October 2018
1 Read

Game Changer: Oral tranexamic acid (TA) in the treatment of melasma: A retrospective analysis.

Authors:
Eden Lake

J Am Acad Dermatol 2018 Oct 30. Epub 2018 Oct 30.

Loyola Univ Medical Center Dermatology. Electronic address:

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October 2018
1 Read

Evaluation of the safety and efficacy of the dual wavelength picosecond laser for the treatment of benign pigmented lesions in Asians.

Lasers Surg Med 2018 Oct 25. Epub 2018 Oct 25.

Division of Dermatology, Department of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Background And Objectives: Cutaneous pigmentary disorders are both more common and more difficult to treat in patients with skin color given the higher melanin content in the epidermis. Although Q-switched lasers are widely considered to be the standard treatment for both epidermal and dermal pigmentary conditions, a very high risk of post-inflammatory hyperpigmentation (PIH) of up to 25% is seen in patients with skin of color. Recently, the novel picosecond laser with pulse durations operating at sub-nanosecond domains has been shown to be effective in tattoo removal and in the treatment of acne scars. Read More

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October 2018
15 Reads

Using reflectance confocal microscopy to observe in vivo melanolysis after treatment with the picosecond alexandrite laser and Q-switched Nd:YAG laser in melasma.

Lasers Surg Med 2018 Oct 23. Epub 2018 Oct 23.

Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.

Objectives: Melasma is an acquired type of hyperpigmentation that is characterized by the appearance of scattered light- to dark-brown macules and patches on the face. Recently, several lasers have been proposed as treatment options for melasma. In particular, the picosecond alexandrite laser is an ideal laser for selective photothermal melanolysis. Read More

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October 2018
1 Read

Diffuse palmoplantar keratotic papules and melanosis.

Int J Dermatol 2019 Jan 21;58(1):e9-e10. Epub 2018 Oct 21.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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January 2019
1 Read

A pilot study of oral tranexamic acid and Glycyrrhizin compound in the treatment of recalcitrant Riehl's melanosis.

J Cosmet Dermatol 2018 Oct 19. Epub 2018 Oct 19.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.

Background: Up till now, there is no standardized and satisfactory treatment strategy for Riehl's melanosis.

Objective: In this pilot study, we evaluated the efficacy and safety of a novel combination therapy with oral administration of tranexamic acid (TA) and Glycyrrhizin compound for recalcitrant Riehl's melanosis.

Methods: Ten patients with Riehl's melanosis were recruited in this study. Read More

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October 2018
3 Reads

A randomized, open-label, comparative study of oral tranexamic acid and tranexamic acid microinjections in patients with melasma.

Indian J Dermatol Venereol Leprol 2018 Oct 17. Epub 2018 Oct 17.

Department of Preventive and Social Medicine, Hindu Rao Hospital, New Delhi, India.

Background: Melasma poses a great challenge as its treatment modalities are unsatisfactory. Treatment using tranexamic acid is a novel concept.

Aim: This study aimed to compare the therapeutic efficacy and safety of oral tranexamic acid and tranexamic acid microinjections in patients with melasma. Read More

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October 2018

Tumoral melanosis associated with combined / inhibition (dabrafenib/trametinib) in metastatic melanoma.

JAAD Case Rep 2018 Oct 10;4(9):921-923. Epub 2018 Oct 10.

Dermatology Research Centre, The University of Queensland, The University of Queensland Diamantina Institute, Brisbane, Australia.

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October 2018
1 Read

Melanocyte activation and skin barrier disruption induced in melasma patients after 1064 nm Nd:YAG laser treatment.

Lasers Med Sci 2018 Oct 9. Epub 2018 Oct 9.

Department of Dermatology, Affiliated Third Hospital of Hangzhou, Anhui Medical University, West Lake Rd 38, Hangzhou, China.

Melasma is a frequently acquired hyperpigmentary skin disorder, for which several therapies are available. Among them, 1064 nm QS Nd:YAG laser therapy is an effective method, but the recurrence rate of laser treatment is still high. The aim of the present study was to elucidate the mechanism of the high relapse rate of melasma after 1064 nm Nd:YAG laser treatment. Read More

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October 2018
2 Reads
2.490 Impact Factor

A dermatoscopic portrait of morphological changes of vulvar melanosis over time.

J Dtsch Dermatol Ges 2018 Nov 9;16(11):1372-1375. Epub 2018 Oct 9.

Unit of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, Policlinico Sant'Orsola-Malpighi, University of Bologna, Italy.

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November 2018
1 Read
1.820 Impact Factor

Beauvericin inhibits melanogenesis by regulating cAMP/PKA/CREB and LXR-α/p38 MAPK-mediated pathways.

Sci Rep 2018 Oct 8;8(1):14958. Epub 2018 Oct 8.

Molecular Dermatology Laboratory, Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon City, 16419, Gyunggi Do, Republic of Korea.

Melanogenesis is the process of production of melanin pigments that are responsible for the colors of skin, eye, and hair and provide protection from ultraviolet radiation. However, excessive levels of melanin formation cause hyperpigmentation disorders such as freckles, melasma, and age spots. Liver X receptors (LXR) are nuclear oxysterol receptors belonging to the family of ligand-activated transcription factors and physiological regulators of lipid and cholesterol metabolism. Read More

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October 2018
6 Reads

The triennial International Pigment Cell Conference (IPCC).

J Transl Med 2018 Oct 3;16(1):252. Epub 2018 Oct 3.

Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, 5200 North Lake Road, Merced, CA, 95343, USA.

The International Federation of Pigment Cell Societies (IFPCS) held its XXIII triennial International Pigment Cell Conference (IPCC) in Denver, Colorado in August 2017. The goal of the summit was to provide a venue promoting a vibrant interchange among leading basic and clinical researchers working on leading-edge aspects of melanocyte biology and disease. The philosophy of the meeting, entitled Breakthroughs in Pigment Cell and Melanoma Research, was to deliver a comprehensive program in an inclusive environment fostering scientific exchange and building new academic bridges. Read More

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October 2018
2 Reads

Frontiers in pigment cell and melanoma research.

Pigment Cell Melanoma Res 2018 Nov 3;31(6):728-735. Epub 2018 Oct 3.

Department of Dermatology, University of Colorado Denver, Aurora, Colorado.

In this perspective, we identify emerging frontiers in clinical and basic research of melanocyte biology and its associated biomedical disciplines. We describe challenges and opportunities in clinical and basic research of normal and diseased melanocytes that impact current approaches to research in melanoma and the dermatological sciences. We focus on four themes: (1) clinical melanoma research, (2) basic melanoma research, (3) clinical dermatology, and (4) basic pigment cell research, with the goal of outlining current highlights, challenges, and frontiers associated with pigmentation and melanocyte biology. Read More

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November 2018
25 Reads

Low-fluence Q-switched Nd:YAG laser for the treatment of melasma in Asian patients.

J Cosmet Dermatol 2018 Dec 2;17(6):1053-1058. Epub 2018 Oct 2.

Department of Dermatology, College of Medicine, Korea University, Seoul.

Background: Melasma is a common acquired facial pigmentary disorder that is resistant to various modalities of treatment. Recently, the low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser (QSNY) has emerged as the new gold standard of melasma treatment in Asia.

Objective: To evaluate the efficacy and safety of low-fluence 1064-nm QSNY in Asian patients with melasma. Read More

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December 2018
2 Reads

Anti-melanogenic effects of oyster hydrolysate in UVB-irradiated C57BL/6J mice and B16F10 melanoma cells via downregulation of cAMP signaling pathway.

J Ethnopharmacol 2019 Jan 28;229:137-144. Epub 2018 Sep 28.

Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea; Department of Preventive Pharmacy and Toxicology, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: Pacific oyster (Crassostrea gigas) has been used to treat pigmentary disorders such as freckles, melasma, and moles in Korea.

Aim Of The Study: We aimed to investigate the inhibitory effects of oyster hydrolysate (OH) on melanogenesis in B16F10 melanoma cells and UVB-irradiated C57BL/6J mice.

Material And Methods: The molecular weight distribution and peptide sequences of OH were detected using MALDI-TOF and UHPLC. Read More

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January 2019

Neurocutaneous Melanosis with Bilateral Temporal Lobe Lesions without Leptomeningeal Enhancement: A Distinct Entity or Subtype.

J Pediatr Neurosci 2018 Jul-Sep;13(3):331-333

Department of Radiology, Command Hospital (Central Command), Lucknow Cantonment, Lucknow, Uttar Pradesh, India.

Neurocutaneous melanosis (NCM) is a rare congenital disorder. Most of the cases described in literature for this entity have involvement of the leptomeninges and other structures of brain such as brain stem, temporal lobes, and spinal meninges and no involvement of leptomeninges and presence of lesions in bilateral temporal lobes. NCM without the involvement of leptomeninges should be considered a distinct entity as the prognosis is favorable as compared to cases with leptomeningeal involvement who develop early hydrocephalus and multiple cranial nerve palsies. Read More

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October 2018
2 Reads

[Primary melanoma of the bladder. A case report].

Rev Esp Patol 2018 Oct - Dec;51(4):244-247. Epub 2018 Feb 23.

Departamento de Patología, Hospital General San Juan de Dios, Guatemala, Guatemala.

Primary melanoma of the urinary bladder is rare. We report a case of a 58-year-old woman, who presented with a 4 month history of dysuria and hematuria. A biopsy indicated a diagnosis of invasive melanoma and a partial cystectomy was performed. Read More

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February 2018
2 Reads

Effect of layer-by-layer antimicrobial edible coating of alginate and chitosan with grapefruit seed extract for shelf-life extension of shrimp (Litopenaeus vannamei) stored at 4 °C.

Int J Biol Macromol 2018 Dec 26;120(Pt B):1468-1473. Epub 2018 Sep 26.

Department of Food and Nutrition, Kookmin University, Seoul 136-702, Republic of Korea. Electronic address:

The effect of a layer-by-layer (LbL) electrostatic deposition coating of alginate and chitosan with grapefruit seed extract was investigated on the shelf life of shrimp (Litopenaeus vannamei) stored for 15 days under refrigeration (4 °C). The shrimp were periodically analyzed for changes in microbiological parameters (total aerobic mesophilic bacteria and total aerobic psychrotrophic bacteria counts), chemical parameters, melanosis, and sensory characteristics. The chitosan-alginate coating had the advantage of reducing the bacterial count by 2 log CFU in combination with the antimicrobial activity of the grapefruit seed extract. Read More

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December 2018

Efficacy of oral tranexemic acid in refractory melasma: A clinico-immuno-histopathological study.

Dermatol Ther 2018 09 25;31(5):e12704. Epub 2018 Sep 25.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Tranexamic acid (TXA), a plasmin inhibitor, is an antifibrinolytic drug widely used to prevent and treat hemorrhage. We evaluated the effects of oral TXA clinically and immunohistopathologically in patients of refractory melasma. To evaluate the efficacy of oral TXA in patients with refractory melasma and correlate histopathological and immunohistochemical changes in pretreatment and post-treatment skin biopsies in patients willing to undergo biopsy. Read More

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September 2018
10 Reads
1.480 Impact Factor

N-acetylcysteine in dermatology.

Indian J Dermatol Venereol Leprol 2018 Nov-Dec;84(6):652-659

Department of Dermatology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

N-acetylcysteine is a mucolytic drug which is commonly used as an antidote for acetaminophen toxicity. It is a thiol compound, which acts as a donor of cysteine, leading to replenishment of glutathione and thus acts as an antioxidant. It also has anti-inflammatory effects, alters the levels of neurotransmitters, inhibits proliferation of fibroblasts and keratinocytes and causes vasodilatation. Read More

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September 2018
7 Reads

Approach to Skin Lightening in Patients With Melasma.

Authors:
Philip R Cohen

J Drugs Dermatol 2018 Sep;17(9):1018

I read with interest the informative article by Spencer et al1 that describes the efficacious use as a novel skin lightening agent (LumaPro-C) for the treatment of patients with melasma. Read More

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September 2018
2 Reads

A Randomized, Double-Blind, Placebo-Controlled, Split-Face Study of the Efficacy of Topical Epidermal Growth Factor for the Treatment of Melasma.

J Drugs Dermatol 2018 Sep;17(9):970-973

Introduction: Melasma is a condition in which patients develop symmetric, reticulated, hyperpigmented macules and patches on the face which is thought to be the result of ultraviolet (UV) exposure and hormonal influences, although the pathogenesis is not completely understood. The topical application of epidermal growth factor has been used as a whitening agent, moisturizer, and an aid for wound healing. In this study, we explore the efficacy of topical EGF in the treatment of melasma. Read More

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September 2018
32 Reads

Melasma treatment with oral tranexamic acid and a novel adjuvant topical therapy.

Authors:
Philip R Cohen

Cutis 2018 Aug;102(2):106

Department of Dermatology, University of California San Diego, USA.

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August 2018
4 Reads

The Management of Melasma on Skin Types V and VI Using Light Emitting Diode Treatment.

Photomed Laser Surg 2018 Oct 18;36(10):522-529. Epub 2018 Sep 18.

2 Faculty of Health Sciences, Laser Research Centre, University of Johannesburg , Doornfontein, South Africa .

Objective: This study investigated light emitting diode (LED) treatment for patients with melasma on darker skin types.

Background: Melasma is a common disfiguring skin condition in women which is difficult to treat and is refractory. The cause of melasma remains unclear. Read More

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October 2018
9 Reads