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    [Vitiligo occurring on dermal melanocytosis (nevus of Ota) in a dark-skinned patient].
    Ann Dermatol Venereol 2017 Jul 17. Epub 2017 Jul 17.
    Service de dermatologie, CHU, Treichville, Côte d'Ivoire.
    Background: Nevus of Ota is a rare disease most frequently found in Asians. It presents clinically as a bluish gray hyperpigmentation of one side of the face. Transformation into melanoma and glaucoma are the main risks. Read More

    Melasma: an Up-to-Date Comprehensive Review.
    Dermatol Ther (Heidelb) 2017 Jul 19. Epub 2017 Jul 19.
    Ronald O. Perelman Department of Dermatology, New York University, New York, NY, USA.
    Melasma is a common acquired condition of symmetric hyperpigmentation, typically occurring on the face, with higher prevalence in females and darker skin types. Multiple etiologies, including light exposure, hormonal influences, and family history, have been implicated in the pathogenesis of this disorder. Overall prevalence ranges widely at 1-50%, since values are typically calculated within a specific ethnic population within a geographic region. Read More

    Anti-melanogenic effect of gomisin N from Schisandra chinensis (Turcz.) Baillon (Schisandraceae) in melanoma cells.
    Arch Pharm Res 2017 Jul 10. Epub 2017 Jul 10.
    College of Pharmacy, Chungbuk National University, 1 Chungdae, Seowon, Cheongju, Chungbuk, 28644, South Korea.
    Overproduction and accumulation of melanin in the skin can lead to pigmentation disorders, such as freckles and melasma. Many researchers are studying the regulation of melanogenesis in the skin with the aim of developing whitening cosmetics. In this study, bioactivity-guided separation of the hexane fraction of Schisandra chinensis (Turcz. Read More

    Microneedling: Where do we stand now? A systematic review of the literature.
    J Plast Reconstr Aesthet Surg 2017 Jun 17. Epub 2017 Jun 17.
    Department of Plastic and Reconstructive Surgery - Burn Center, University Hospital of Ghent, De Pintelaan 185, 9000 Ghent, Belgium.
    Background: Patients who suffer from scars or wrinkles have several therapeutic options to improve the appearance of their skin. The available treatment modalities that provide desirable results are often overtly invasive and entail a risk of undesirable adverse effects. Microneedling has recently emerged as a non-ablative alternative for treating patients who are concerned with the aesthetic changes that result from injury, disease or ageing. Read More

    Role of oxidative stress in melasma: a prospective study on serum and blood markers of oxidative stress in melasma patients.
    Int J Dermatol 2017 Jul 5. Epub 2017 Jul 5.
    Skin Department, Skinnocence Skin Clinic, Gurgaon, India.
    Background: Melasma is a common pigmentary disorder presenting in the dermatological clinic. Many factors have been implicated in the pathogenesis, however, the cause still remains elusive. Recently the effect of oxidative damage has been proposed in the etiopathogenesis of melasma. Read More

    Efficacy of cysteamine cream in the treatment of epidermal melasma, evaluating by Dermacatch as a new measurement method: A randomized double blind placebo controlled study.
    J Dermatolog Treat 2017 Jul 5:1-28. Epub 2017 Jul 5.
    b Scientis Pharma SA , Geneva , Switzerland.
    Background: Melasma is a difficult-to-treat hyperpigmentary disorder. Very few studies have been performed regarding the efficacy of cysteamine in the treatment of melasma.

    Objective: To determine the efficacy of cysteamine cream in the treatment of patients with epidermal melasma using Dermacatch(®) as a more accurate skin colorimetric measurement tool. Read More

    Late Solitary Extraocular Recurrence from Previously Resected Iris Melanoma.
    Am J Ophthalmol 2017 Jun 30. Epub 2017 Jun 30.
    Ocular Oncology Service, Moorfields Eye Hospital, London, UK; UCL Institute of Ophthalmology, London.
    Purpose: To report on cases of late extraocular relapse of previously resected iris melanoma, without concurrent intraocular recurrence.

    Design: Retrospective case series.

    Methods: A retrospective chart review of 4 patients diagnosed with late subconjunctival relapse of previously resected iris melanoma. Read More

    The role of oligomenorrhea in melasma.
    Med Hypotheses 2017 Jul 8;104:1-3. Epub 2017 May 8.
    Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
    Melasma is a facial hyperpigmentation in the upper lips, cheeks, forehead and chin. It is mostly seen in women. Melasma treatments include topical methods that are not only costly, but also temporary. Read More

    Tranexamic acid inhibits melanogenesis by activating the autophagy system in cultured melanoma cells.
    J Dermatol Sci 2017 Jun 7. Epub 2017 Jun 7.
    Department of Biomedical Science, BK21-plus Research Team for Bioactive Control Technology, National Research Center for Dementia, College of Natural Sciences, Chosun University, Gwangju 61452, Republic of Korea. Electronic address:
    Background: As interest in skin beauty increases, the development of new skin whitening agents has attracted substantial attention; however, the action mechanism of the agents developed so far remains largely unknown. Tranexamic acid (TXA) is commonly being used to reduce melanin synthesis in patients with melasma and also used as a raw material for functional whitening cosmetics, although its action mechanism is poorly understood. Autophagy has been well known to be essential for tissue homeostasis, adaptation to starvation, and removal of dysfunctional organelles or pathogens. Read More

    A split-face, investigator-blinded comparative study on the efficacy and safety of Q-switched Nd:YAG laser plus microneedling with vitamin C versus Q-switched Nd:YAG laser for the treatment of recalcitrant melasma.
    J Cosmet Laser Ther 2017 Jun 28. Epub 2017 Jun 28.
    a Istanbul Medipol University , Medical Faculty, Dermatology Department.
    Background: High recurrence has previously been reported in the treatment of melasma with low-fluence 1,064-nm QS-Nd:YAG laser. However, the efficacy and safety of QS-Nd:YAG laser plus microneedling with vitamin C has not been evaluated in patients with mixed-type melasma.

    Material And Methods: Sixteen patients with recalcitrant dermal- or mixed-type melasma were included in the study. Read More

    Cancer risk in patients with Peutz-Jeghers syndrome: A retrospective cohort study of 336 cases.
    Tumour Biol 2017 Jun;39(6):1010428317705131
    1 Department of Gastroenterology, Clinical College of Air Force General Hospital, Anhui Medical University, Beijing, China.
    Peutz-Jeghers syndrome is a rare autosomal dominant inherited disorder characterized by mucocutaneous pigmentation and hamartomatous gastrointestinal polyposis. A growing body of evidence has shown that Peutz-Jeghers syndrome could cause an increased risk of various cancers, yet the range of cancer risk estimates was wide among different studies. In this retrospective cohort study, 336 patients with Peutz-Jeghers syndrome in China were enrolled. Read More

    Retrospective Analysis of Endemic Melasma Patients.
    Dermatol Reports 2017 Mar 16;9(1):7027. Epub 2017 May 16.
    Department of Gynecology and Obstetric, Kirkkale University, Kirikkale, Turkey.
    Melasma is an acquired diffuse hypermelanosis characterized by localized, symmetrical, irregular, light-to-dark brown maculae occurring in sun-exposed areas of skin. The aim of this retrospective study was to determine demographics of patients, analysis of etiologic factors, clinical features, efficacy and side effects of available topical treatments due to high incidence of melasma patients. In this study melasma patients in Birecik State Hospital were investigated retrospectively. Read More

    Therapeutic efficacy and safety of oral tranexamic acid and that of tranexamic acid local infiltration with microinjections in patients with melasma: a comparative study.
    Clin Exp Dermatol 2017 Jun 25. Epub 2017 Jun 25.
    Department of Dermatology, Venereology and Leprosy, Dr RP Govt Medical College, Kangra (Tanda), India.
    Background: Tranexamic acid (TXA) has been used orally, intravenously, topically and intradermally (microinjection, microneedling) for treating melasma. However, the comparative efficacy of these different routes of administration remains underevaluated.

    Aim: To ascertain the comparative efficacy of different routes of administration of TXA. Read More

    Biocompatible polymer microneedle for topical/dermal delivery of tranexamic acid.
    J Control Release 2017 Jun 20;261:87-92. Epub 2017 Jun 20.
    University of Waterloo, Waterloo, Ontario, Canada.
    Recently-introduced biocompatible polymeric microneedles offer an efficient method for drug delivery. Tranexamic acid is a novel drug for treating melasma that is administered both locally and orally and inhibits excessive melanin via melanocyte. The tranexamic acid biocompatible polymer microneedle used in this study was fabricated from PVP and methacrylic acid, using the lithography method. Read More

    Efficacy of surgical laser therapy in the management of oral pigmented lesions: A systematic review.
    J Photochem Photobiol B 2017 Jun 15;173:353-359. Epub 2017 Jun 15.
    Division of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, United States.
    Background: Oral pigmentation, especially in the gingiva poses esthetic problems. Laser therapy has been widely used for cosmetic therapy in dentistry. The aim of the present study was to systematically review the efficacy of surgical laser therapy (SLT) in the management of oral pigmented lesions (OPL). Read More

    Arginase-2, a miR-1299 target, enhances pigmentation in melasma by reducing melanosome degradation via senescence-induced autophagy inhibition.
    Pigment Cell Melanoma Res 2017 Jun 19. Epub 2017 Jun 19.
    Department of Dermatology, Dongguk University Ilsan Hospital, Goyang-si, Gyeonggi-do, South Korea.
    Expression profiles revealed miR-1299 downregulation concomitant with arginase-2 (ARG2) upregulation in hyperpigmented skin of melasma patients. Opposite regulation of tyrosinase and PMEL17 by miR-1299 and inverse relationship between miR-1299 and ARG2 expression denoted a role of miR-1299 in pigmentation with ARG2 as a miR-1299 target. ARG2 overexpression or knock-down in keratinocytes, the main source of ARG2 in epidermis, positively regulated tyrosinase and PMEL17 protein levels, but not mRNA levels or melanosome transfer. Read More

    Isolation and Characterization of Isofraxidin 7-O-(6'-O-p-Coumaroyl)-β-glucopyranoside from Artemisia capillaris Thunberg: A Novel, Nontoxic Hyperpigmentation Agent That Is Effective In Vivo.
    Evid Based Complement Alternat Med 2017 24;2017:1401279. Epub 2017 May 24.
    New Drug Targets Laboratory, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712, Republic of Korea.
    Abnormalities in skin pigmentation can produce disorders such as albinism or melasma. There is a research need to discover novel compounds that safely and effectively regulate pigmentation. To identify novel modulators of pigmentation, we attempted to purify compounds from a bioactive fraction of the Korean medicinal plant Artemisia capillaris Thunberg. Read More

    A Deceptively Simple Solution for Refractory Melasma: Glycolic Acid Peels and Hydroquinone at Home.
    Plast Reconstr Surg Glob Open 2017 May 19;5(5):e1335. Epub 2017 May 19.
    Department of Plastic Surgery, University of Tokyo School of Medicine, Tokyo, Japan; and Department of Plastic Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
    Although various treatment methods for melasma have developed, substantial improvement of the condition is sometimes difficult. We have experientially found that some of refractory melasma caused by daily friction can easily be treated by using a combination of a peeling agent (20% glycolic acid) and a depigmenting agent (5% hydroquinone) twice daily at home. And here, by performing skin biopsies, we revealed the pathological mechanism: hyperkeratosis caused by repeated physical stimulus, which prevents infiltration of topical therapeutic agents, was dramatically reduced by chemical peeling, resulting that the melanin pigments were effectively cleared by topical hydroquinone. Read More

    Ophthalmic Manifestations of Xeroderma Pigmentosum: A Perspective from the United Kingdom.
    Ophthalmology 2017 May 26. Epub 2017 May 26.
    Nationally Commissioned Xeroderma Pigmentosum Service, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom; Department of Ophthalmology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
    Purpose: To document the ocular manifestations of xeroderma pigmentosum (XP), presenting via the United Kingdom (UK) XP service, and to analyze the correlations between XP genotype and ophthalmic phenotype.

    Design: Prospective observational case series.

    Subjects: Eighty-nine patients seen by the UK Nationally Commissioned XP Service, from April 2010 to December 2014, with a genetically confirmed diagnosis of XP. Read More

    The first transepidermal transplantation of non-cultured epidermal suspension using a dermarolling system in vitiligo: A sequential histological and clinical study.
    Pigment Cell Melanoma Res 2017 May 19. Epub 2017 May 19.
    Vitiligo Melasma Research Association, Lacanau, France.
    The current methods for melanocyte delivery to depigmented skin are invasive and often require sophisticated approaches. Here, we describe a promising simple and minimally invasive technique based on the dermarolling system. The technique involves preparation of a keratinocyte/melanocyte suspension prepared by trypsinization from a non-lesioned part of a patient's scalp skin and transepidermal delivery using a dermaroller equipped with 0. Read More

    Development of a quantitative assessment method of pigmentary skin disease using ultraviolet optical imaging.
    Skin Res Technol 2017 May 21. Epub 2017 May 21.
    Research Institute for Skin Image, College of Medicine, Korea University, Seoul, South Korea.
    Background/purpose: The visual scoring method has been used as a subjective evaluation of pigmentary skin disorders. Severity of pigmentary skin disease, especially melasma, is evaluated using a visual scoring method, the MASI (melasma area severity index). This study differentiates between epidermal and dermal pigmented disease. Read More

    Epidemiology and Predisposing Factors for Erythema Toxicum Neonatorum and Transient Neonatal Pustular: A Multicenter Study.
    Pediatr Dermatol 2017 Jul 25;34(4):422-426. Epub 2017 May 25.
    Department of Dermatology, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
    Background/objectives: Erythema toxicum neonatorum (ETN) and transient neonatal pustular melanosis (TNPM) are benign pustular skin conditions that are relatively common in newborns, but the predisposing factors for these conditions are unknown. Our goal was to verify the prevalence of ETN and TNPM and their predisposing factors in a large sample of neonates.

    Methods: In this prospective 1-year multicenter study, 2,831 neonates (age ≤72 hours) born in southern Brazil were randomized to undergo skin examination by a dermatologist. Read More

    Eosinophilic annular erythema is clinically characterized by central pigmentation reflecting basal melanosis: a clinicopathological study of 10 cases.
    J Eur Acad Dermatol Venereol 2017 May 22. Epub 2017 May 22.
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Background: Eosinophilic annular erythema (EAE) has been proposed as a clinical entity to describe annular skin lesions associated with tissue eosinophilia. However, systematic investigations on the histopathology of EAE have not been performed, and useful histopathological findings for diagnosis of EAE remain unknown.

    Objective: The aim of this study was to investigate the clinicopathological features of EAE. Read More

    Successful Treatment of Becker's Nevus With Long-Pulsed 1064nm Nd:YAG and 755nm Alexandrite Laser and Review of the Literature.
    J Cosmet Laser Ther 2017 May 12. Epub 2017 May 12.
    b Gateway Aesthetic Institute & Laser Center , Salt Lake City , UT.
    Background: Becker's Nevus is an aesthetically troublesome condition secondary to hyperpigmentation and hypertrichosis. Although several lasers have been employed with varying degrees of success, the exact devices and treatment parameters have yet to be elucidated.

    Objective: To assess the combination Nd:Yag and alexandrite laser as a safe and efficacious treatment for Becker's Nevus. Read More

    A review of laser and light therapy in melasma.
    Int J Womens Dermatol 2017 Mar 21;3(1):11-20. Epub 2017 Mar 21.
    Department of Dermatology, Palo Alto Medical Foundation, Sunnyvale, California.
    Melasma is a dysregulation of the homeostatic mechanisms that control skin pigmentation and excess pigment is produced. Traditional treatment approaches with topical medications and chemical peels are commonly used but due to the refractory and recurrent nature of melasma, patients often seek alternative treatment strategies such as laser and light therapy. Several types of laser and light therapy have been studied in the treatment of melasma. Read More

    Updates in the understanding and treatments of skin & hair disorders in women of color.
    Int J Womens Dermatol 2017 Mar 16;3(1 Suppl):S21-S37. Epub 2017 Feb 16.
    Department of Dermatology, Howard University College of Medicine, Washington, District of Columbia.
    Skin of color comprises a diverse and expanding population of individuals. In particular, women of color represent an increasing subset of patients who frequently seek dermatologic care. Acne, melasma, and alopecia are among the most common skin disorders seen in this patient population. Read More

    Efficacy of functional microarray of microneedles combined with topical tranexamic acid for melasma: A randomized, self-controlled, split-face study.
    Medicine (Baltimore) 2017 May;96(19):e6897
    aDepartment of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing bSuzhou NanoMED skincare Inc, Suzhou, China.
    To evaluate the efficacy of a functional microarray of microneedles (MNs) plus topical tranexamic acid (TA) for melasma in middle-aged women in China.Thirty female subjects with melasma were enrolled in this study. The left or right side of the face was chosen randomly to be pretreated with a functional microarray of MNs, followed by topical 0. Read More

    Cochlear implantation and clinical features in patients with Noonan syndrome and Noonan syndrome with multiple lentigines caused by a mutation in PTPN11.
    Int J Pediatr Otorhinolaryngol 2017 Jun 17;97:228-234. Epub 2017 Apr 17.
    Department of Otorhinolaryngology, Head and Neck Surgery, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
    Existing literature only reports a few patients with Noonan syndrome (NS) and Noonan syndrome with multiple lentigines (NSML) who underwent cochlear implantation (CI). The present study describes four NS patients and one NSML patient with a PTPN11 mutation. They all had severe to profound hearing loss, and they received a CI. Read More

    Novel regulation of melanogenesis by adiponectin via the AMPK/CRTC pathway.
    Pigment Cell Melanoma Res 2017 May 8. Epub 2017 May 8.
    Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    Several studies observed that adiponectin, an important adipokine that improves glucose metabolism by regulating AMP-activated protein kinase (AMPK) signaling, is dermatologically beneficial. In our recent microarray data, we found that adiponectin expression was lower in lesional skin than in non-lesional skin of melasma patients. Given that AMPK is a key adiponectin signaling mediator, we investigated the role of adiponectin and AICAR, a cell-permeable AMPK activator, in melanogenesis. Read More

    Peutz-Jeghers syndrome with intermittent upper intestinal obstruction: A case report and review of the literature.
    Medicine (Baltimore) 2017 Apr;96(17):e6538
    aDepartment of Pediatric Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China bDepartment of Radiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
    Rationale: Peutz-Jeghers syndrome (PJS) is an autosomal dominant genetic syndrome characterized by a unique type of gastrointestinal hamartomatous polyp associated with oral and anal mucocutaneous pigmentations. Peutz-Jeghers polyps occur most numerously in the small intestine but frequently in the colon and stomach, only a few cases have been reported in the duodenum.

    Patient Concern: A further family history survey discovered 10 out of 14 members of the family (in 4 generations) had mucocutaneous pigmentations, but many of them were living in rural areas where they had no access to specialized medical services, so none were checked with endoscopy for polyps of hamartoma. Read More

    Noninvasive RCM for Differentiation of Melanotic Macules From Melanocytic Lesions-Blinded Evaluation of a Series of 42 Pigmented Macules.
    Dermatol Surg 2017 Jul;43(7):911-919
    *Department of Dermatology, Paracelsus Medical University of Salzburg, Salzburg, Austria; †Department of Dermatology, Medical University of Graz, Graz, Austria, Europe.
    Background: Differentiation of melanotic macules from melanocytic lesions, most importantly of melanoma, is a common problem on clinical-dermoscopic examination.

    Objective: To assess the value of noninvasive reflectance confocal microscopy (RCM) in the differential diagnosis of melanotic macules and melanocytic lesions.

    Patients And Methods: Reflectance confocal microscopy images of 42 pigmented macules on mucocutaneous junctions of genitalia and lips, including 31 melanotic macules, 6 nevi, and 5 melanomas, were retrospectively and independently assessed in a blinded manner by one expert observer and 2 less experienced observers together. Read More

    Oral pigmentations in physiologic conditions, post inflammatory affections and systemic diseases.
    G Ital Dermatol Venereol 2017 Apr 19. Epub 2017 Apr 19.
    Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy -
    Melanocytes are found throughout the oral mucosa but usually go unnoticed because of their relatively low level of pigment production. When focally or generally active in pigment production or proliferation they may be responsible for several affections in the oral mucosae ranging from physiologic pigmentation, systemic diseases to malignant neoplasms. The diagnosis of oral pigmentations (OP) is usually challenging for the physician, but a careful examination of the oral cavity may reveal the first manifestation of underlying systemic diseases. Read More

    Effect of catechin and its derivatives on inhibition of polyphenoloxidase and melanosis of Pacific white shrimp.
    J Food Sci Technol 2017 Apr 24;54(5):1098-1107. Epub 2017 Feb 24.
    Department of Food Science and Agricultural Chemistry, McGill University (Macdonald Campus), 21,111 Lakeshore Road, Sainte-Anne-de-Bellevue, QC H9X 3V9 Canada.
    This study aimed to investigate the effect of tea catechin (C) and 4 of its derivatives on the Pacific white shrimp PPO inhibition and melanosis during refrigerated storage. Epigallocatechin gallate (EGCG) exhibited the highest inhibition towards PPO, followed by C. Inhibitory activity of all compounds tested was in a dose dependent manner (0. Read More

    Supratentorial intermediate grade meningeal melanocytoma with intratumoral bleed in the background of neurocutaneous melanosis: Report of an unusual case and review of literature.
    Asian J Neurosurg 2017 Jan-Mar;12(1):98-102
    Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
    Primary melanocytic tumours of the central nervous system (CNS) are rare. According to the WHO classification (2007), these tumours include diffuse leptomeningeal melanosis, melanomatosis, melanocytoma, and primary CNS melanoma. Meningeal melanocytoma, most commonly seen in the infratentorial compartment and cervical spinal cord, is a benign primary melanocytic neoplasm. Read More

    Microneedling in All Skin Types: A Review.
    J Drugs Dermatol 2017 Apr;16(4):308-313

    INTRODUCTION: Microneedling procedures are growing in popularity for a wide variety of skin conditions. This paper comprehensively reviews the medical literature regarding skin needling efficacy and safety in all skin types and in multiple dermatologic conditions.

    METHODS: A PubMed literature search was conducted in all languages without restriction and bibliographies of relevant articles reviewed. Read More


    Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma: Case report.
    Medicine (Baltimore) 2017 Apr;96(15):e6470
    aDepartment of Dermatology, Venereology and Allergology, Wroclaw Medical University bDepartment of Pathomorphology, Wroclaw Medical University, Wroclaw, Poland.
    Rationale: Diffuse melanosis cutis (DMC) is a very rare sign of malignant melanoma progression. The condition usually develops after approximately one year from melanoma diagnosis in a patient with metastatic tumors and after anticancer treatment with cytostatic medications.

    Patient Concerns: A 72-year old Caucasian man was admitted to the Department of Dermatology with DMC for 4 months and the history of two melanomas treated surgically 30 years and 9 months before present hospitalization. Read More

    Conjunctival Tumors: Review of Clinical Features, Risks, Biomarkers, and Outcomes--The 2017 J. Donald M. Gass Lecture.
    Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):109-120
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA.
    Conjunctival tumors encompass a broad range of diagnoses. The 3 most important malignant tumors include ocular surface squamous neoplasia (OSSN) (14%), melanoma (12%), and lymphoma (7%). Conjunctival malignancies are rarely found in children. Read More

    Salicylic acid peeling combined with vitamin C mesotherapy versus salicylic acid peeling alone in the treatment of mixed type melasma: A comparative study.
    J Cosmet Laser Ther 2017 Apr 7:1-6. Epub 2017 Apr 7.
    a Medical Faculty, Dermatology Department , School of Medicine, İstanbul Medipol University , Istanbul , Turkey.
    Introduction: Melasma is a distressing condition for both dermatologists and patients. We evaluated the effectiveness of salicylic acid (SA) peel and vitamin C mesotherapy in the treatment of melasma.

    Materials And Methods: Fifty female patients were divided into two groups. Read More

    Coumestrol Down-Regulates Melanin Production in Melan-a Murine Melanocytes through Degradation of Tyrosinase.
    Biol Pharm Bull 2017 ;40(4):535-539
    Amorepacific R&D Corporation Center.
    Pigmentation reflects skin darkening caused by melanin production, but excessive melanin synthesis may cause problems, such as melasma, solar lentigo, dark spots, and freckles. Considerable effort has been devoted to alleviating these undesired symptoms through the development of safe and effective depigmenting agents. Coumestrol, a plant-derived natural isoflavone with an estrogen-like structure and actions, is known to have anti-aging ability, but its potential depigmenting efficacy has not been evaluated. Read More

    Efficacy and Safety of Tranexamic Acid in Melasma: A Meta-analysis and Systematic Review.
    Acta Derm Venereol 2017 Jul;97(7):776-781
    Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea.
    Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Read More

    Primary intranasal melanoma with brain invasion in a dog.
    Can Vet J 2017 Apr;58(4):391-396
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1 (Lemetayer); Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Al-Dissi, Tryon, MacDonald-Dickinson).
    A 6-year-old castrated male boxer dog with right-sided dark purulent nasal discharge and acute bilateral blindness was diagnosed on magnetic resonance imaging (MRI) and then on necropsy with primary nasal malignant melanoma that extended into the brain, as well as concurrent ocular melanosis. There was no evidence of metastasis in other organs. Read More

    Metastatic melanoma with features of blue nevus and tumoral melanosis identified during pembrolizumab therapy.
    JAAD Case Rep 2017 Mar 15;3(2):135-137. Epub 2017 Mar 15.
    Department of Dermatology, Penn State Health Hershey Medical Center, Hershey, Pennsylvania.
    Metastatic melanoma may exhibit clinical or histologic features of blue nevus. Pembrolizumab therapy is associated with regression and tumoral melanosis. We report on a man with widespread metastatic melanoma on pembrolizumab therapy in whom a blue-grey papule developed on the left side of his neck that clinically resembled a blue nevus and histologically showed features of both blue nevus and tumoral melanosis. Read More

    Melasma Associated with Topical Estrogen Cream.
    J Clin Aesthet Dermatol 2017 Feb 1;10(2):57-58. Epub 2017 Feb 1.
    Chairman, Department of Dermatology Herbert Wertheim College of Medicine, Florida International University, and Director, Greater Miami Skin and Laser Center, Mount Sinai Medical Center.
    A 47-year-old woman presented with hyperpigmented patches on her upper extremities. The patient had begun using a topical estrogen cream in the affected areas prior to noticing the hyperpigmentation. A diagnosis of melasma secondary to topical estrogen cream was made. Read More

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