9,349 results match your criteria Melasma


[Melanosis of adipose tissue in a 17-month-old German Fleckvieh bull (Bos taurus)].

Tierarztl Prax Ausg G Grosstiere Nutztiere 2019 Apr 18;47(2):121-124. Epub 2019 Apr 18.

Fleischygieneamt.

At meat inspection of a 17-month-old bull (German Fleckvieh), patchy dark discoloration of various organs and tissue sites was noted that was most prominent in perirenal adipose tissue. Microscopic analysis revealed melanosis, that is a congenital melanocytic dystopia, as the underlying cause. To the best of our knowledge, this is the first case of melanosis detected in adipose tissue in cattle. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0866-6421
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http://dx.doi.org/10.1055/a-0866-6421DOI Listing
April 2019
1 Read

Dietary Protein Deficit and Deregulated Autophagy: A New Clinico-diagnostic Perspective in Pathogenesis of Early Aging, Skin, and Hair Disorders.

Indian Dermatol Online J 2019 Mar-Apr;10(2):115-124

Department of Dermatology, Aesthetic Surgery and Intervention Dermatology, AURA Skin Institute, Chandigarh, India.

Background: Diet has an important role to play in the well-being of human body.

Aims: The study intends to establish the "hypothesis of conscious, selective, and self-destruction i.e. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_123_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434747PMC
April 2019
4 Reads

Imatinib-induced Melasma-like Pigmentation.

Indian J Dermatol 2019 Mar-Apr;64(2):158-159

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India. E-mail:

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http://dx.doi.org/10.4103/ijd.IJD_302_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440189PMC

Combination of Hydroquinone and Fractional CO Laser versus Hydroquinone Monotherapy in Melasma Treatment: A Randomized, Single-blinded, Split-face Clinical Trial.

Indian J Dermatol 2019 Mar-Apr;64(2):129-135

Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Melasma is a chronic hyperpigmentation skin disorder mainly affecting women in the reproductive age. Available treatments for melasma do not lead to long-term satisfactory results.

Aims: This study aimed to compare the efficacy of fractional CO laser in combination with topical therapy to topical therapy alone. Read More

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http://dx.doi.org/10.4103/ijd.IJD_240_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440181PMC

Assessment of Melanogenesis in a Pigmented Human Tissue-Cultured Skin Equivalent.

Indian J Dermatol 2019 Mar-Apr;64(2):85-89

Department of Dermatology, Venereology, and Allergology, Goethe University Hospital, Frankfurt/Main, Germany.

Background: Organotypic tissue-cultured skin equivalents are used for a broad range of applications either as possible substitute for animal tests or for transplantation in patient-centered care.

Aims: In this study, we implemented melanocytes in a tissue-cultured full-thickness skin equivalent, consisting of epidermis and dermis. The versatility of this skin-like model with respect to pigmentation and morphological criteria was tested. Read More

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http://www.e-ijd.org/text.asp?2019/64/2/85/254158
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http://dx.doi.org/10.4103/ijd.IJD_410_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440179PMC
April 2019
5 Reads

Transplantation of a Blue Kidney: A Case Report.

Transplant Proc 2019 Feb 8. Epub 2019 Feb 8.

School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey; Organ Transplantation Center, Acibadem International Hospital, Istanbul, Turkey.

A blue kidney, although very rare, can be encountered upon a live kidney donor. Literature has shown hemosiderin deposits, lipofuscin pigment, and melanosis as possible reasons. We report on a 37-year-old woman who wished to donate a kidney to her husband. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.091DOI Listing
February 2019

A cream of herbal mixture to improve melasma.

J Cosmet Dermatol 2019 Apr 13. Epub 2019 Apr 13.

Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, China.

Background: Melasma is an acquired, common hyperpigmented disorder on the face. While many therapeutic approaches are available, their efficacy is moderate.

Objective: To investigate the safety and efficacy of a cream containing herbal mixture for melasma. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12938
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http://dx.doi.org/10.1111/jocd.12938DOI Listing
April 2019
1 Read

Laryngeal Melanosis: A Worrisome Finding?

Ear Nose Throat J 2019 Apr 8:145561319838724. Epub 2019 Apr 8.

1 Department of Otolaryngology, Tulane University Medical Center, New Orleans, LA, USA.

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http://dx.doi.org/10.1177/0145561319838724DOI Listing

Distribution and Characteristics of Polyphenoloxidase from Pacific White Shrimp (Litopenaeus vannamei).

J Food Sci 2019 Apr 8. Epub 2019 Apr 8.

Authors are with Faculty of Agro-Industry, Dept. of Food Technology, Prince of Songkla Univ., Hat Yai, Songkhla, 90112, Thailand.

Distribution of polyphenoloxidase (PPO) from different anatomical parts of Pacific white shrimp was examined. Among all parts, cephalothorax possessed the maximal PPO activity (P < 0.05), followed by pereopods, telson, pleopods, carapace, cuticle, and muscle, respectively. Read More

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http://dx.doi.org/10.1111/1750-3841.14593DOI Listing
April 2019
1 Read
1.696 Impact Factor

A New HPLC-DAD Method for the Concurrent Determination of Hydroquinone, Hydrocortisone Acetate and Tretinoin in Different Pharmaceuticals for Melasma Treatment.

J Chromatogr Sci 2019 Apr 3. Epub 2019 Apr 3.

Department of Agro-Environmental Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.

A new simple and robust HPLC-DAD method was developed for the concurrent analysis of hydroquinone (HQ), hydrocortisone acetate (HCA) and tretinoin (TRN) triple combination for the first time using an Inertsil ODS 3-C18 column (150 mm × 4.6 mm, 5 μm particle size) column with 0.05 M phosphate buffer (pH 5. Read More

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https://academic.oup.com/chromsci/advance-article/doi/10.109
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http://dx.doi.org/10.1093/chromsci/bmz020DOI Listing
April 2019
7 Reads

Aggressive Primary Pediatric Intracranial Malignant Melanoma: Sphinx of the Tissue Diagnosis.

Asian J Neurosurg 2019 Jan-Mar;14(1):275-279

Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences, Bengaluru, Karnataka, India.

It is often intriguing to suspect and confirm the diagnosis of primary malignant melanoma (PMM) in the brain without any evidence of neurocutaneous melanosis. We report a 16-year-old male patient with malignant melanoma which intraoperatively was small sized, soft, fleshy, hemorrhagic in appearance resembling hematoma. Interestingly, the histopathology showed prominent papillary architecture with a differential diagnosis of papillary meningioma and ependymoma and perplexed the tissue diagnosis. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_253_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417341PMC
April 2019
2 Reads

Melanosis Coli.

Authors:
Greg S Cohen

Clin Gastroenterol Hepatol 2019 Mar 27. Epub 2019 Mar 27.

Clinical Assistant Professor of Medicine, Northwestern University, Department of Medicine, Division of Gastroenterology and Hepatology, 201 E Huron Street, Suite 11-205, Chicago, IL 60611.

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http://dx.doi.org/10.1016/j.cgh.2019.03.032DOI Listing
March 2019
1 Read

A novel triple combination in treatment of melasma: Significant outcome with far less actives.

Authors:
Erkin Pekmezci

J Cosmet Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Dermatology Department, Gozde Hospital, Malatya, Turkey.

Background: Melasma is an acquired hyperpigmentation, often involving the face, and a source of distress for the affected individuals. Although treatment is challenging and frequently a multimodality approach, topical applications are the mainstay of therapy.

Objective: Due to the frequent relapses, a therapy both acting rapidly and suitable for long-term use, with fewer adverse effects should be administered. Read More

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http://dx.doi.org/10.1111/jocd.12904DOI Listing
March 2019
1 Read

Hyperpigmentation Disorders in Hispanic Population in the United States

Authors:
Marta I. Rendon

J Drugs Dermatol 2019 Mar;18(3):s112-114

The Hispanic population is the third largest growing group in the United States and is projected to increase to 119 million by 2060. Skin of color populations including Hispanics are more susceptible to a variety of pigmentary disorders including melasma and post-inflammatory hyperpigmentation (PIH). Most previous treatment options for these disorders remain unsatisfactory. Read More

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March 2019
12 Reads

Hyperpigmentation Disorders in Hispanic Population in the United States

Authors:
Marta I. Rendon

J Drugs Dermatol 2019 Mar;18(3):s112-114

The Hispanic population is the third largest growing group in the United States and is projected to increase to 119 million by 2060. Skin of color populations including Hispanics are more susceptible to a variety of pigmentary disorders including melasma and post-inflammatory hyperpigmentation (PIH). Most previous treatment options for these disorders remain unsatisfactory. Read More

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March 2019
5 Reads

Quantification of Hypopigmentation Activity In Vitro.

J Vis Exp 2019 Mar 6(145). Epub 2019 Mar 6.

Department of Biotechnology, Graduate School of Life Sciences & Biotechnology, College of Life Sciences and Biotechnology, Korea University;

This study presents laboratory methods for the quantification of hypopigmentation activity in vitro. Melanin, the major pigment in melanocytes, is synthesized in response to multiple cellular and environmental factors. Melanin protects skin cells from ultraviolet damage, but also has biophysical and biochemical functions. Read More

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http://dx.doi.org/10.3791/58185DOI Listing
March 2019
1 Read

Esophageal Melanosis : A rare condition of undetermined significance.

Clin Gastroenterol Hepatol 2019 Mar 19. Epub 2019 Mar 19.

UCLA David Geffen School of Medicine, LA. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.03.025DOI Listing
March 2019
1 Read

Ringlike pattern as a dermatoscopy sign for vulvar melanosis does not preclude synchronous existence of vulvar melanoma.

J Eur Acad Dermatol Venereol 2019 Mar 21. Epub 2019 Mar 21.

Department of Surgical Oncology, Institute of Oncology and Radiology of Serbia, University of Belgrade, Belgrade, Serbia.

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http://dx.doi.org/10.1111/jdv.15589DOI Listing

Diffuse Melanosis and Melanuria.

N Engl J Med 2019 03;380(12):1166

Azienda Unità Sanitaria Locale di Reggio Emilia-IRCCS, Reggio Emilia, Italy

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http://dx.doi.org/10.1056/NEJMicm1810151DOI Listing

CDH1 and DDR1 common variants confer risk to vitiligo and autoimmune comorbidities.

Gene 2019 Jun 16;700:17-22. Epub 2019 Mar 16.

Vitiligo and Melasma Research Association, Bordeaux, France.

The weaker expression of the two main proteins adhering melanocytes to the epidermis basal layer, Epithelial Cadherin (E-cadherin) and Discoidin Domain Receptor Tyrosine kinase 1 (DDR1), has been implicated as one of the aggravating factors in the loss of melanocytes in vitiligo. The present study was designed to assess the association between single nucleotide polymorphisms (SNP) in the genes encoding these proteins, CDH1 and DDR1, and the risk of developing vitiligo. The independent case-control study was conducted on the sample including152 patients with vitiligo and 152 matched controls. Read More

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http://dx.doi.org/10.1016/j.gene.2019.03.026DOI Listing

Laryngeal Melanosis.

Ear Nose Throat J 2019 Feb 4;98(2):70-71. Epub 2019 Feb 4.

1 Department of Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1177/0145561318823317DOI Listing
February 2019

How hormones may modulate human skin pigmentation in melasma: an in vitro perspective.

Authors:
Muriel Cario

Exp Dermatol 2019 Mar 18. Epub 2019 Mar 18.

Univ. Bordeaux, Inserm, BMGIC, UMR1035, 33 076, Bordeaux, France.

Melasma is a common acquired hyperpigmentary disorder occurring primarily in photo-exposed areas and mainly affecting women of childbearing age. To decipher the role of sex hormones in melasma, this viewpoint reviews the effects of sex hormones on cutaneous cells cultured in monolayers, in coculture, in 3D models and explants in the presence or absence of UV. The data show that sex steroid hormones, especially estrogen, can modulate in vitro pigmentation by stimulating melanocytes and keratinocyte pro-pigmentary factors, but not via fibroblast or mast cell activation. Read More

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http://dx.doi.org/10.1111/exd.13915DOI Listing
March 2019
1 Read

Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology.

J Eur Acad Dermatol Venereol 2019 Mar 14. Epub 2019 Mar 14.

National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt.

Background: Lasers and intense pulsed light sources (IPLS) are proposed for the treatment of many pigmentary disorders. They are sometimes considered as magic tools able to remove any type of lesions. Although being the best option for several hyperpigmented lesions, they can also worsen some conditions and have potential side-effects. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15497
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http://dx.doi.org/10.1111/jdv.15497DOI Listing
March 2019
6 Reads

Malignant transformation of neurocutaneous melanosis (NCM) following immunosuppression.

Pediatr Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York City, New York.

Neurocutaneous melanosis (NCM) is the condition of abnormal melanocyte deposition in the leptomeninges and brain parenchyma. Associated with congenital melanocytic nevi, NCM can result in neurologic deficits, hydrocephalus, and rarely, malignant transformation of cells. We present the case of a 16-year-old boy with NCM who developed malignant leptomeningeal melanoma following immunosuppression with a TNFα inhibitor. Read More

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http://dx.doi.org/10.1111/pde.13804DOI Listing
March 2019
4 Reads

Comparison of the efficacy of intradermal injected tranexamic acid vs hydroquinone cream in the treatment of melasma.

Clin Cosmet Investig Dermatol 2019 14;12:115-122. Epub 2019 Feb 14.

Dermatology Department, Emam Hospital, School of Medicine, Ahvaz University of Medical Science, Ahvaz, Iran,

Background: Melasma is a common benign acquired pigmentary dermatosis due to a disorder in the function of the melanogenesis process. Although several treatments are currently used, it remains a great challenge.

Aim: The aim of this study is to compare the efficacy of intradermal injected tranexamic acid (TA) vs hydroquinone (HQ) cream in the treatment of melasma. Read More

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https://www.dovepress.com/comparison-of-the-efficacy-of-intr
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http://dx.doi.org/10.2147/CCID.S191964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386353PMC
February 2019
8 Reads

What's New in Pigmentary Disorders.

Dermatol Clin 2019 Apr 16;37(2):175-181. Epub 2019 Feb 16.

Department of Dermatology, Henry Ford Hospital System, 3031 West Grand Boulvard, Suite 800, Detroit, MI 48202, USA. Electronic address:

Pigmentary disorders are common and can be very distressing to patients. There is a need for better, standardized therapies. The authors review the most recent data for topical, systemic, light, and laser treatments for vitiligo, melasma, and postinflammatory hyperpigmentation. Read More

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http://dx.doi.org/10.1016/j.det.2018.12.008DOI Listing
April 2019
5 Reads

A retrospective review of conjunctival melanoma: Presentation, treatment and evolution.

Arch Soc Esp Oftalmol 2019 Mar 4. Epub 2019 Mar 4.

Unidad de Tumores del Adulto, Servicio de Oftalmología, Hospital Clínico Universitario de Valladolid, Valladolid, España.

Objective: The purpose of the present study is to describe the clinical characteristics and outcomes of patients diagnosed and treated for conjunctival melanoma in the Ocular Oncology Unit of the University Hospital Clinic of Valladolid.

Methods: A retrospective observational case series study was conducted on patients diagnosed with conjunctival melanoma in the Ocular Oncology Unit of University Hospital Clinic of Valladolid, from January 1992 to December 2017. Demographic information and tumour features were recorded in a Microsoft Access database. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03656691193004
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http://dx.doi.org/10.1016/j.oftal.2019.01.008DOI Listing
March 2019
5 Reads

Structural studies of plasmin inhibition.

Biochem Soc Trans 2019 Mar 5. Epub 2019 Mar 5.

ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Melbourne 3800, Australia

Plasminogen (Plg) is the zymogen form of the serine protease plasmin (Plm), and it plays a crucial role in fibrinolysis as well as wound healing, immunity, tissue remodeling and inflammation. Binding to the targets via the lysine-binding sites allows for Plg activation by plasminogen activators (PAs) present on the same target. Cellular uptake of fibrin degradation products leads to apoptosis, which represents one of the pathways for cross-talk between fibrinolysis and tissue remodeling. Read More

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http://dx.doi.org/10.1042/BST20180211DOI Listing
March 2019
3 Reads

Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma.

J Invest Dermatol 2019 Feb 27. Epub 2019 Feb 27.

Beiersdorf AG, Hamburg, Germany. Electronic address:

Melasma is a pigmentary disorder characterized by hyperpigmented patchy skin in sun-exposed areas, especially the face. Treatment of melasma can be challenging since long-term therapy is required, reoccurrence is common and existing therapies are insufficient and unsatisfactory. To investigate new treatment options, we performed an exploratory double-blinded, randomized split-face study to assess the efficacy of the tyrosinase inhibitor Thiamidol compared to hydroquinone in women with mild to moderate melasma. Read More

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http://dx.doi.org/10.1016/j.jid.2019.02.013DOI Listing
February 2019

Ascorbic acid derivative-loaded modified aspasomes: formulation, in vitro, ex vivo and clinical evaluation for melasma treatment.

J Liposome Res 2019 Mar 1:1-14. Epub 2019 Mar 1.

d Department of Dermatology, Venereology and Andrology, Faculty of Medicine , Ain Shamas University , Cairo , Egypt.

Vitamin C (L-Ascorbic acid) has many favourable effects on the skin such as antioxidant, anti-aging and whitening effects. Its instability and low permeability limit its pharmaceutical use in cosmetic and dermatological products. Instead, Mg ascorbyl phosphate (MAP), an ascorbic acid derivative, has the same effect with higher stability is being used. Read More

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http://dx.doi.org/10.1080/08982104.2019.1585448DOI Listing
March 2019
1 Read

Resveratrol as a Multifunctional Topical Hypopigmenting Agent.

Int J Mol Sci 2019 Feb 22;20(4). Epub 2019 Feb 22.

Department of Dermatology, Seoul National University Bundang Hospital, Seongnam 463-707, Korea.

Melanin is produced in melanocytes and stored in melanosomes, after which it is transferred to keratinocytes and, thus, determines skin color. Despite its beneficial sun-protective effects, abnormal accumulation of melanin results in esthetic problems. A range of topical hypopigmenting agents have been evaluated for their use in the treatment of pigmentary disorders with varying degrees of success. Read More

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http://dx.doi.org/10.3390/ijms20040956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412432PMC
February 2019

New oral and topical approaches for the treatment of melasma.

Int J Womens Dermatol 2019 Feb 20;5(1):30-36. Epub 2018 Nov 20.

Vitiligo & Pigmentation Institute of Southern California, Los Angeles, California.

Melasma is a common, therapeutically challenging, and universally relapsing disorder of hyperpigmentation that is most often observed in women and individuals with Fitzpatrick Skin Types III through VI. The pathogenesis of melasma is complex and protean. Contributing factors that are often implicated in the etiopathogenesis of this condition include a genetic predisposition, intense ultraviolet radiation exposure, and hormonal influences. Read More

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http://dx.doi.org/10.1016/j.ijwd.2018.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374710PMC
February 2019

Platelet-rich plasma, a powerful tool in dermatology.

J Tissue Eng Regen Med 2019 Feb 22. Epub 2019 Feb 22.

Cellular and Functional Biology and Biomolecules Engineering Group, School of Science, Universidad Antonio Nariño, Bogotá, Colombia.

Platelet-rich plasma (PRP), a platelet concentrate contained in a small volume of plasma, has become a promising option in the last decade to treat different diseases related to the skin due to its high concentration of growth factors. When it is of autologous origin, it decreases the probability of suffering adverse reactions and transfusion-transmitted infections, thus it is an optimal and safe therapy for the patient. PRP has been used in the treatment of several dermatological conditions such as acne, alopecia, and skin ulcers. Read More

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http://dx.doi.org/10.1002/term.2832DOI Listing
February 2019
6 Reads

Neurocutaneous Melanosis in Association With Large Congenital Melanocytic Nevi in Children: A Report of 2 Cases With Clinical, Radiological, and Pathogenetic Evaluation.

Front Neurol 2019 7;10:79. Epub 2019 Feb 7.

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.

Melanocytic nevi present at birth, or within the first few months of life, are defined as congenital melanocytic nevi (CMN). Neurocutaneous melanosis (NCM) is a rare disorder, represents pigment cell tumors of the leptomeninges, and occurs in association with large or multiple CMN. NCM carries an extremely poor prognosis. Read More

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http://dx.doi.org/10.3389/fneur.2019.00079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374324PMC
February 2019
2 Reads

Melanoma arising in a Giant congenital melanocytic nevus: two case reports.

Diagn Pathol 2019 Feb 19;14(1):21. Epub 2019 Feb 19.

Federal State Budgetary Institution, "N.N. Blokhin Medical Research Center of Oncology" of the Ministry of Health of the Russian Federation, 115478 Kashirskoye shosse, 24, Moscow, Russian Federation.

Background: A giant congenital melanocytic nevus (GCMN) is found in 0.1% of live-born infants. If present, the lesion has a chance of about 6% to develop into malignant melanoma. Read More

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http://dx.doi.org/10.1186/s13000-019-0797-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381634PMC
February 2019
2 Reads

Melasma: How hormones can modulate skin pigmentation.

J Cosmet Dermatol 2019 Apr 18;18(2):458-463. Epub 2019 Feb 18.

San Gallicano Dermatological Institute (IRCCS), Rome, Italy.

We described-along with a genetic predisposition and exposure to sunlight, as the main factors for melasma development-pregnancy, hormonal therapies, and oral contraceptive pills. Whilst hormonal alteration or therapies are frequently reported in literature in association with melasma, studies analyzing the laboratoristic correlation are limited. We review data published on hormones variations both in women and males with melasma and report some peculiar clinical cases that further demonstrate how the relationship between hormone secretion and melasma development is difficult to be defined. Read More

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http://dx.doi.org/10.1111/jocd.12877DOI Listing
April 2019
1 Read

Efficacy of microneedling with topical vitamin C in the treatment of melasma.

J Cosmet Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Faculty of Medicine, Department of Dermatology, Sohag University, Sohag University Hospital, Sohag, Egypt.

Background: Despite the wide therapeutic options available for the treatment of melasma, including many active topical medications, technologies with lights and peelings, clinical control of this disorder is extremely challenging.

Objectives: To evaluate the effect of microneedling with topical vitamin C in the treatment of melasma.

Methods: Thirty female patients with melasma received six sessions of microneedling with addition of topical vitamin C every two weeks. Read More

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http://dx.doi.org/10.1111/jocd.12878DOI Listing
February 2019
1 Read

Parry-Romberg syndrome treatment with fat transfer and a new bleaching formula.

J Cosmet Dermatol 2019 Feb 15. Epub 2019 Feb 15.

ISAPS, Athens, Greece.

Parry-Romberg syndrome is a hemifacial atrophy which can be complicated by melasma. We present two cases of Parry-Romberg syndrome, treated by fat transfer and bleaching of the skin using a modified "Kligman's formula." The atrophy, as well as the skin dyschromia, improved, and the results were stable. Read More

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http://dx.doi.org/10.1111/jocd.12819DOI Listing
February 2019
3 Reads

Ocular Surface Squamous Neoplasia Hiding in Primary Acquired Melanosis.

JAMA Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miami, Florida.

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http://archopht.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaophthalmol.2018.6503DOI Listing
February 2019
11 Reads

Acanthosis nigricans, hypochondroplasia, and FGFR3 mutations: Findings with five new patients, and a review of the literature.

Pediatr Dermatol 2019 Mar 14;36(2):242-246. Epub 2019 Feb 14.

Department of Dermatology, CHU Nantes, Nantes, France.

Early development of extensive acanthosis nigricans (AN) is a key feature in some patients who have hypochondroplasia (HCH) in association with FGFR3 mutations. We here report regarding five new patients with HCH who exhibited AN, and we compare their characteristics to the eight patients previously described in the literature. In these patients, the AN lesions began in childhood, and they were extensive. Read More

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http://dx.doi.org/10.1111/pde.13748DOI Listing
March 2019
1 Read

Gastric Tumoral Melanosis: a Rare Manifestation of Successfully Treated Malignant Melanoma.

Clin Gastroenterol Hepatol 2019 Feb 8. Epub 2019 Feb 8.

Department of General Medical Oncology, University Hospitals Leuven, KU Leuven, Belgium.

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http://dx.doi.org/10.1016/j.cgh.2019.02.006DOI Listing
February 2019
5 Reads

Efficacy of mesotherapy with tranexamic acid and ascorbic acid with and without glutathione in treatment of melasma: A split face comparative trial.

J Cosmet Dermatol 2019 Feb 8. Epub 2019 Feb 8.

Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Introduction: Melasma is a prevalent annoying skin hyperpigmentation disorder that commonly involves reproductive-aged females. Variety of treatments with controversial results has been recommended. The aim of the current study was to evaluate combination therapy of tranexamic acid (TA) and vitamin C with and without glutathione with mesotherapy technique for treatment of melasma. Read More

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http://dx.doi.org/10.1111/jocd.12874DOI Listing
February 2019
1 Read
1.000 Impact Factor

Analysis of the effect of different doses of oral tranexamic acid on melasma: a multicentre prospective study.

Eur J Dermatol 2019 Feb;29(1):55-58

Department of Dermatology, Kinki University Faculty of Medicine, Higashiosaka, Japan.

Background: Melasma is pale brown to dark brown hyperpigmentation of the facial skin that commonly affects women of reproductive age. Treatment methods for melasma include oral and topical use of vitamin C, hydroquinone ointment, and laser treatment, with unsatisfactory results. Tranexamic acid (TA) has been shown to be effective against melasma, however, the optimal dose has not been investigated. Read More

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http://dx.doi.org/10.1684/ejd.2018.3494DOI Listing
February 2019
3 Reads

Laser and Laser Compound Therapy for Melasma: A Meta-Analysis.

J Dermatolog Treat 2019 Jan 31:1-19. Epub 2019 Jan 31.

b Clinical Research Center, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine , Guangzhou 510006 , China.

Background: Treatment of melasma is challenging because its pathogenesis is unclear and it is prone to recurrence. We performed a meta-analysis to evaluate the efficacy and safety of laser and laser compound therapy for melasma.

Methods: We searched the Cochrane, Embase, and Medline databases for all relevant studies published from inception to July 2018. Read More

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http://dx.doi.org/10.1080/09546634.2019.1577544DOI Listing
January 2019
1 Read

Peutz-Jeghers Syndrome.

N Engl J Med 2019 Jan;380(5):472

R.G. Kar Medical College and Hospital, Kolkata, India

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http://dx.doi.org/10.1056/NEJMicm1806623DOI Listing
January 2019
1 Read

[Clinicopathological features of non-neoplastic colorectal polyps].

Authors:
L Jiang Y F Jiao

Zhonghua Bing Li Xue Za Zhi 2019 Feb;48(2):98-101

Department of Pathology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China.

To characterize clinicopathological characteristics of the non-neoplastic colorectal polyps for accurate diagnosis. 1 190 cases were collected from the Second Affiliated Hospital of Harbin Medical University from January 2012 to December 2016 and their clinicopathological characteristics were reviewed. There were 746 males and 444 females patients with male/female ratio of 1. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.02.004DOI Listing
February 2019
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Black and Brown Oro-facial Mucocutaneous Neoplasms.

Authors:
Easwar Natarajan

Head Neck Pathol 2019 Mar 29;13(1):56-70. Epub 2019 Jan 29.

Section of Oral and Maxillofacial Pathology, University of Connecticut Health Center, 263 Farmington Ave, MC-0925, Farmington, CT, 06030, USA.

Black and brown-colored mucocutaneous lesions present a differential diagnostic challenge, with malignant melanoma being the primary clinical concern. The vast majority of pigmented lesions in the head and neck region are the result of benign, reactive factors such as post-inflammatory melanosis. However, it is not uncommon to discover a range of muco-cutaneous black and brown neoplasms in the oro-facial area. Read More

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http://dx.doi.org/10.1007/s12105-019-01008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406009PMC
March 2019
4 Reads

Black and Brown: Non-neoplastic Pigmentation of the Oral Mucosa.

Head Neck Pathol 2019 Mar 22;13(1):47-55. Epub 2019 Jan 22.

Louisiana State University, 1100 Florida Avenue, New Orleans, LA, 70119, USA.

Black and brown pigmentation of the oral mucosa can occur due to a multitude of non-neoplastic causes. Endogenous or exogenous pigments may be responsible for oral discoloration which can range from innocuous to life-threatening in nature. Physiologic, reactive, and idiopathic melanin production seen in smoker's melanosis, drug-related discolorations, melanotic macule, melanoacanthoma and systemic diseases are presented. Read More

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http://dx.doi.org/10.1007/s12105-018-0980-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405786PMC
March 2019
11 Reads

An herbal H2 blocker in melasma treatment.

Curr Drug Discov Technol 2019 Jan 21. Epub 2019 Jan 21.

Health center, Mashhad University of Medical Sciences, Mashhad. Iran.

Background: Melasma is a skin pigmentation disorder that remains resistant to available therapies. The exact cause of melasma is unknown. Histamine is an inflammatory factor. Read More

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http://dx.doi.org/10.2174/1570163816666190121145653DOI Listing
January 2019
8 Reads

Efficacy of Trifecting Night Cream, a Novel Triple acting Skin Brightening Product: A Double-blind, Placebo-controlled Clinical Study.

J Clin Aesthet Dermatol 2018 Dec 1;11(12):21-25. Epub 2018 Dec 1.

Drs. Jiang, Hino, and Stephens are with Thomas J. Stephens & Associates in Richardson, Texas.

Melasma is a common, persistent disorder of hyperpigmented facial skin predominantly attributed to ultraviolet light exposure, hormonal influences, and genetic predisposition. This double-blind, placebo-controlled, randomized clinical trial was conducted to assess the efficacy and tolerance of a multimodality night cream when used over a course of 24 weeks followed by a four-week regression in female subjects with moderate to severe melasma, presence of solar lentigines, and periocular lines and wrinkles. Subjects were randomized into one of two groups: Cell 1 received Trifecting Night Cream (Envy Medical, Long Beach, California) 1. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334832PMC
December 2018