10,546 results match your criteria Melasma

Dermatology: how to manage facial hyperpigmentation in skin of colour.

Drugs Context 2022 31;11. Epub 2022 May 31.

Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Hyperpigmentation disorders, such as post-inflammatory hyperpigmentation and melasma, are common conditions affecting all skin types. These conditions are largely benign and are influenced by numerous endogenous and exogenous factors impacting melanocyte activity and melanin production. Current treatment modalities for these conditions fall into broad categories, including photoprotection, topical and systemic therapies, chemical peels, and laser or light-based therapies. Read More

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Azole inhibitors of mushroom and human tyrosinases: Current advances and prospects of drug development for melanogenic dermatological disorders.

Usman Ghani

Eur J Med Chem 2022 Jun 9;239:114525. Epub 2022 Jun 9.

Clinical Biochemistry Unit, Department of Pathology, College of Medicine, King Saud University, Riyadh, 12372, Saudi Arabia. Electronic address:

Azoles are a famous and promising class of drugs for treatment of a range of ailments especially fungal infections. A wide variety of azole derivatives are also known to exhibit tyrosinase inhibition, some of which possess promising activity with potential for treatment of dermatological disorders such as post-inflammatory hyperpigmentation, nevus, flecks, melasma, and melanoma. Recently, thiazolyl-resorcinol derivatives have demonstrated potent human tyrosinase inhibition with a safe and effective therapeutic profile for treatment of skin hyperpigmentation in humans, which are currently under clinical trials. Read More

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Central nervous system magnetic resonance imaging abnormalities and neurologic outcomes in pediatric patients with congenital nevi: A 10-year multi-institutional retrospective study.

J Am Acad Dermatol 2022 Jun 15. Epub 2022 Jun 15.

Department of Dermatology, Massachusetts General Hospital, Boston, MA; Dermatology Program, Department of Allergy and Immunology, Boston Children's Hospital, Boston, MA; Harvard Medical School, Boston, MA.

Background: High-risk congenital melanocytic nevi (CMN) are associated with abnormalities of the central nervous system, prompting MRI screening guidelines.

Objective: Describe MRI brain and spine abnormalities in children with CMN and report trends between nevus features, MRI findings, and neurologic outcomes.

Methods: Retrospective review of individuals aged ≤ 18 years with an MRI of brain and/or spine and at least 1 dermatologist-diagnosed CMN. Read More

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Esophageal Melanocytosis: report of two cases and review of a rare and misunderstood entity.

Acta Gastroenterol Belg 2022 Apr-Jun;85(2):390-392

Department of Pathology, Institut de Pathologie et de Génétique, Gosselies, Belgium.

Esophageal melanocytosis (EM) is a rare entity, which is characterized by a non-atypical melanocytic proliferation and melanin deposits in the esophageal mucosa. The confusion between the terms of melanosis and melanocytosis in the literature, the rarity of this lesion (less than 50 cases reported in the literature), its uncertain pathobiological course and the lack of experience of pathologists and gastroenterologists prompt us to draw the attention to this particular entity by reporting two cases and reviewing the literature. Magnifying endoscopy to observe intensive melanin accumulation followed by a biopsy are key for the diagnosis. Read More

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Pigmentation Control in Pregnancy-Induced Melasma: Clinical Assessment of a Non-hydroquinone, Non-retinol Pigment-Correcting Serum.

J Cosmet Dermatol 2022 Jun 16. Epub 2022 Jun 16.

Allergan Aesthetics, an AbbVie Company, Irvine, CA, USA.

Background: Melasma is an acquired disorder that results in irregular brown patches on the skin that can occur due to hormonal changes. Although pregnancy-induced melasma is usually temporary, it can become a chronic condition, with significant negative impact on quality of life (QoL).

Aims: Determine the efficacy and tolerability of a topical, non-hydroquinone, non-retinol pigment-correcting serum (LYT2) for the treatment of pregnancy-induced melasma. Read More

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The effectiveness of tomato extract on superoxide dismutase (SOD) and severity degree of patients with melasma.

Ital J Dermatol Venerol 2022 Jun;157(3):262-269

Department of Dermatovenereology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia.

Background: Melasma is present in 40% of cases in Southeast Asia. The condition is often unresponsive to therapy; treatment has variable success rates, and melasma has high recurrence rates. Lycopene-rich tomato extract is needed to avoid oxidative stress due to ultraviolet rays that cause melasma through the melanogenesis pathway. Read More

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The protective effect of a novel sunscreen against blue light.

Int J Cosmet Sci 2022 Jun 10. Epub 2022 Jun 10.

Hyphens Pharma Pte Ltd, 16, Tai Seng Street, Level 4, 534138, Singapore.

Background And Objective: Premature skin ageing, and skin hyperpigmentation are influenced by exogenous factors such as ultraviolet radiation and blue light. In this study, we assess the protective effect of a sunscreen (TDF® Blu Voile Sunscreen) in protecting the skin against the harmful effects of blue light irradiation in vivo and through the in situ quantitative and qualitative evaluation of protein carbonylation in human skin explants.

Methodology: The protective effect of the test product against blue light was first evaluated ex vivo on human skin explants. Read More

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Berardinelli-Seip Congenital Lipodystrophy - A Case Report and Review of Literature.

J Coll Physicians Surg Pak 2022 Jun;32(6):817-819

Department of Medicine, Fatima Memorial Hospital, College of Medicine and Dentistry, Lahore, Pakistan.

Berardinelli-Seip Congenital Lipodystrophy (BSCL), also known as congenital generalised lipodystrophy, is a genetic disorder where there is an absolute deficiency of adipose tissue. It affects the development of adipocytes and ultimately leads to an inability to store fat in adipocytes. It is extremely rare. Read More

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Endoscopic Therapy of Small Bowel Polyps by Single-Balloon Enteroscopy in Patients with Peutz-Jeghers Syndrome.

Int J Clin Pract 2022 1;2022:7849055. Epub 2022 Feb 1.

Department of Gastroenterology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.

Background: Little is known about the efficacy and safety of single-balloon enteroscopy (SBE) in patients with Peutz-Jeghers syndrome (PJS). The aim of this study was to assess the efficacy and safety of SBE for the treatment of small bowel polyps in patients with PJS.

Methods: We conducted a single-center observational study, which included all patients diagnosed with PJS who underwent SBE for polypectomy between January 2018 and March 2021. Read More

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Antamanide Analogs as Potential Inhibitors of Tyrosinase.

Int J Mol Sci 2022 Jun 2;23(11). Epub 2022 Jun 2.

Institute of Biomolecular Chemistry of CNR, Padova Unit, Via F. Marzolo, 1, 35131 Padova, Italy.

The tyrosinase enzyme, which catalyzes the hydroxylation of monophenols and the oxidation of -diphenols, is typically involved in the synthesis of the dark product melanin starting from the amino acid tyrosine. Contributing to the browning of plant and fruit tissues and to the hyperpigmentation of the skin, leading to melasma or age spots, the research of possible tyrosinase inhibitors has attracted much interest in agri-food, cosmetic, and medicinal industries. In this study, we analyzed the capability of antamanide, a mushroom bioactive cyclic decapeptide, and some of its glycine derivatives, compared to that of pseudostellarin A, a known tyrosinase inhibitor, to hinder tyrosinase activity by using a spectrophotometric method. Read More

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Laccase Mediator Cocktail System as a Sustainable Skin Whitening Agent for Deep Eumelanin Decolorization.

Int J Mol Sci 2022 Jun 2;23(11). Epub 2022 Jun 2.

Department of Biological and Ecological Sciences, University of Tuscia, 01100 Viterbo, Italy.

The overproduction of eumelanin leads to a panel of unaesthetic hyper-pigmented skin diseases, including melasma and age spots. The treatment of these diseases often requires the use of tyrosinase inhibitors, which act as skin whitening agents by inhibiting the synthesis of eumelanin, with harmful side effects. We report here that laccase from in association with a cocktail of natural phenol redox mediators efficiently degraded eumelanin from , offering an alternative procedure to traditional whitening agents. Read More

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Hydroxychloroquine induced melanosis.

Reumatol Clin (Engl Ed) 2022 Jun-Jul;18(6):377-378

Rheumatology Department, Centro Hospitalar de Vila Nova de Gaia e Espinho, Vila Nova de Gaia, Portugal.

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Morphological and transcriptional evaluation of multiple facial cutaneous hyperpigmented spots.

Skin Health Dis 2022 Jun 4;2(2):e96. Epub 2022 Feb 4.

Department of Dermatology College of Medicine University of Cincinnati Cincinnati Ohio USA.

Background: Morphological characteristics of major facial hyperpigmented spots have been well documented. However, detailed alterations of respective transcriptional profile for each spot and in-depth comparisons across multiple spot types have not been reported.

Objectives: To comprehensively assess and compare multiple facial hyperpigmented spot types at the morphological and molecular levels by utilising transcriptional expression profiling with correlation to quantified histological features. Read More

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Dermoscopic classification of melasma: Concordance study and correlation with the melanophages count.

J Cosmet Dermatol 2022 Jun 8. Epub 2022 Jun 8.

Professor Rubem David Azulay Dermatology Institute, Santa Casa da Misericordia do Rio de Janeiro, Rio de Janeiro, Brazil.

Background: Melasma is a common hypermelanosis characterized by symmetrical brownish macules, especially on the face. Histologic analysis demonstrates increased epidermal and dermal melanin. Dermoscopy is useful to estimate the depth of the melanin and may help in the diagnosis and classification of melasma, with therapeutic importance. Read More

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[The 495th case: young female-hyperandrogenemia-severe insulin resistance].

Zhonghua Nei Ke Za Zhi 2022 Jun;61(6):703-707

State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

A 22-year-old female has complained of hirsutism, acanthosis nigricans, enlarged clitoris, and menstrual disorders since puberty. Laboratory examinations revealed hyperandrogenemia. Severe insulin resistance and diabetes were found during hospitalization in our hospital. Read More

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Evaluating resurfacing modalities in aesthetics.

Clin Dermatol 2022 May-Jun;40(3):274-282. Epub 2021 Feb 2.

Department of Dermatology, Alpert Medical School, Brown University, Providence, Rhode Island, USA; GK Dermatology, PC, South Weymouth, Massachusetts, USA; Department of Dermatology, Medical School of Jundiaí, São Paulo, Brazil. Electronic address:

Skin resurfacing for cutaneous rejuvenation has evolved with the development of a plethora of nonsurgical and minimally invasive modalities. We have highlighted the advances in laser therapy, chemical peels, radiofrequency, microneedling, and platelet-rich plasma therapy. We have also included studies providing head-to-head comparisons between procedures and discussed relevant debates in the field. Read More

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Maintenance Outcomes of the Children's Healthy Living Program on Overweight, Obesity, and Acanthosis Nigricans Among Young Children in the US-Affiliated Pacific Region: A Randomized Clinical Trial.

JAMA Netw Open 2022 Jun 1;5(6):e2214802. Epub 2022 Jun 1.

Department of Human Nutrition, Food and Animal Sciences, College of Tropical Agriculture and Human Resources, University of Hawai'i at Mānoa, Honolulu.

Importance: Few obesity prevention trials among children have demonstrated sustainable outcomes in the long term.

Objectives: To sustain a community-wide decrease in the prevalence of overweight and obesity among young children in the US-affiliated Pacific region.

Design, Setting, And Participants: In the Children's Healthy Living community-randomized clinical trial, hierarchical modeling comparing the change in intervention and control communities accounted for community randomization (community clustering with jurisdictions), and adjusted for the age and sex distribution of the assessed children in a cross-sectional design. Read More

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Continuing Medical Education Questions: June 2022.

Akwi W Asombang

Am J Gastroenterol 2022 Jun 17;117(6):844. Epub 2022 Feb 17.

Massachusetts General Hospital, Boston, Massachusetts.

Article Title: Diagnosis and Management of Cancer Risk in the Gastrointestinal Hamartomatous Polyposis Syndromes: Recommendations From the US Multi-Society Task Force on Colorectal Cancer. Read More

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Dermoscopy as an efficient aid to diagnose pigmentary and vascular component of periorbital melanosis: A cross-sectional study.

J Cosmet Dermatol 2022 Jun 4. Epub 2022 Jun 4.

Department of Dermatology, AIIMS, Raipur, India.

Introduction: Periorbital melanosis (POM) has a significant impact on quality of life. There is a dearth of literature regarding POM, especially in Asian population. Accurate classification of POM is contributory to the choice of therapy. Read More

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Melanosis coli: A factor not associated with histological progression of colorectal polyps.

J Dig Dis 2022 Jun 4. Epub 2022 Jun 4.

Department of Gastroenterology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Objective: The association of melanosis coli (MC) with increased colorectal polyp detection rate (PDR) is causal or simply because dark background making detection of polyps more easily remains to be studied. This retrospective study was conducted to research the association of MC with colorectal polyps.

Methods: 1104 MC patients with 2208 controls (matched by age, gender, bowel preparation quality) and 490 MC polyps with 980 controls (matched by age, gender, size and location of polyps) were enrolled. Read More

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Light Brown and Pink Macule on the Upper Arm.

Cutis 2022 02;109(2):87-97

HCA Healthcare/University of South Florida Morsani College of Medicine, Graduate Medical Education, Largo Medical Center.

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February 2022

A rare cause of mechanical intestinal obstruction due to small bowel intussusception: 'A solitary Peutz-Jeghers type hamartomatous polyp'.

Ulus Travma Acil Cerrahi Derg 2022 Jun;28(6):879-883

Department of General Surgery, Trakya University Faculty of Medicine, Edirne-Turkey.

Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant disorder which is characterized by hyperpigmentation in mucocutaneous membranes and hamartomatous polyps in the gastrointestinal tract (GIT). Common complications reported in patients with PSJ are bleeding and mechanical intestinal obstruction due to the hamartomatous polyps. There is also an increased risk of gastrointestinal and extra-intestinal malignancies in patients with PJS. Read More

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Commentary on "Metabolic Syndrome in Melasma: A case-control study".

J Cosmet Dermatol 2022 Jun 1. Epub 2022 Jun 1.

Department of Dermatology, International Mongolian Hospital of Inner Mongolia, Hohhot, China, 010020.

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Topical Treatments for Melasma and Their Mechanism of Action.

J Clin Aesthet Dermatol 2022 May;15(5):19-28

Dr. González is with Mount Sinai Hospital in New York, New York.

Objective: We conducted a review of topical agents currently used in melasma, discussing their mechanism of action, efficacy, safety, and tolerability, with an update on newer treatments.

Methods: A systematic review from PubMed database was performed, using PRISMA guidelines. The search was limited to English and Spanish studies that were double or single blinded, prospective, controlled or randomized clinical trials, reviews of literature, and meta-analysis studies. Read More

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Efficacy of low-fluence 1064 nm Q-switched Nd: YAG laser for the treatment of melasma: A meta-analysis and systematic review.

J Cosmet Dermatol 2022 May 27. Epub 2022 May 27.

Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, China.

Background: Melasma is considered as a type of acquired facial pigmentary disorder that is challenging to treat. Low-fluence 1064 nm Q-switched Nd: YAG laser (LQSNY) has clinical benefits against melasma; however, there are some disputes.

Objective: To explore these contentious views, we conducted a meta-analysis and systematic review to evaluate the efficacy and safety of LQSNY monotherapy and combined therapy for the treatment of melasma. Read More

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[Diagnostic utility of colonoscopy and histological evaluation in the study of patients with chronic diarrhea].

Rev Gastroenterol Peru 2021 Oct-Dec;41(4):221-226

Clínica Colsanitas. Bogotá, Colombia.

Introduction: Patients with chronic diarrhea often undergo colonoscopy evaluation, however, the performance of biopsies or ileoscopy remains controversial.

Objective: To evaluate the usefulness of colonoscopy plus biopsies in the study of patients with chronic diarrhea.

Materials And Methods: We retrospectively reviewed patients with chronic diarrhea who underwent colonoscopy between 2015 and 2019. Read More

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The peppered moth Biston betularia.

Curr Biol 2022 May;32(10):R447-R448

Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Henry Wellcome Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

Hannah Rowland and colleagues introduce the peppered moth whose industrial melanism was an early evidence for evolution. Read More

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Phlorotannins-bioactivity and extraction perspectives.

J Appl Phycol 2022 May 17:1-13. Epub 2022 May 17.

ICAR-Central Institute of Fisheries Technology (CIFT), Cochin-29, Cochin, India.

Phlorotannins, a seaweed based class of polyphenolic compounds, have proven to possess potential bioactivities such as antioxidant, antimicrobial, anti-allergic, anti-diabetic, anti-inflammatory, anti-cancerous, neuroprotection etc. These bioactivities have further increased demand globally and sustainable techniques such as supercritical fluid extraction, microwave assisted extraction, enzyme assisted extraction, extraction using deep eutectic solvents etc. are being explored currently for production of phlorotannin-rich extracts. Read More

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