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    Oral pigmentations in physiologic conditions, post inflammatory affections and systemic diseases.
    G Ital Dermatol Venereol 2017 Apr 19. Epub 2017 Apr 19.
    Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy -
    Melanocytes are found throughout the oral mucosa but usually go unnoticed because of their relatively low level of pigment production. When focally or generally active in pigment production or proliferation they may be responsible for several affections in the oral mucosae ranging from physiologic pigmentation, systemic diseases to malignant neoplasms. The diagnosis of oral pigmentations (OP) is usually challenging for the physician, but a careful examination of the oral cavity may reveal the first manifestation of underlying systemic diseases. Read More

    Effect of catechin and its derivatives on inhibition of polyphenoloxidase and melanosis of Pacific white shrimp.
    J Food Sci Technol 2017 Apr 24;54(5):1098-1107. Epub 2017 Feb 24.
    Department of Food Science and Agricultural Chemistry, McGill University (Macdonald Campus), 21,111 Lakeshore Road, Sainte-Anne-de-Bellevue, QC H9X 3V9 Canada.
    This study aimed to investigate the effect of tea catechin (C) and 4 of its derivatives on the Pacific white shrimp PPO inhibition and melanosis during refrigerated storage. Epigallocatechin gallate (EGCG) exhibited the highest inhibition towards PPO, followed by C. Inhibitory activity of all compounds tested was in a dose dependent manner (0. Read More

    Supratentorial intermediate grade meningeal melanocytoma with intratumoral bleed in the background of neurocutaneous melanosis: Report of an unusual case and review of literature.
    Asian J Neurosurg 2017 Jan-Mar;12(1):98-102
    Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
    Primary melanocytic tumours of the central nervous system (CNS) are rare. According to the WHO classification (2007), these tumours include diffuse leptomeningeal melanosis, melanomatosis, melanocytoma, and primary CNS melanoma. Meningeal melanocytoma, most commonly seen in the infratentorial compartment and cervical spinal cord, is a benign primary melanocytic neoplasm. Read More

    Microneedling in All Skin Types: A Review.
    J Drugs Dermatol 2017 Apr;16(4):308-313

    INTRODUCTION: Microneedling procedures are growing in popularity for a wide variety of skin conditions. This paper comprehensively reviews the medical literature regarding skin needling efficacy and safety in all skin types and in multiple dermatologic conditions.

    METHODS: A PubMed literature search was conducted in all languages without restriction and bibliographies of relevant articles reviewed. Read More


    Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma: Case report.
    Medicine (Baltimore) 2017 Apr;96(15):e6470
    aDepartment of Dermatology, Venereology and Allergology, Wroclaw Medical University bDepartment of Pathomorphology, Wroclaw Medical University, Wroclaw, Poland.
    Rationale: Diffuse melanosis cutis (DMC) is a very rare sign of malignant melanoma progression. The condition usually develops after approximately one year from melanoma diagnosis in a patient with metastatic tumors and after anticancer treatment with cytostatic medications.

    Patient Concerns: A 72-year old Caucasian man was admitted to the Department of Dermatology with DMC for 4 months and the history of two melanomas treated surgically 30 years and 9 months before present hospitalization. Read More

    Conjunctival Tumors: Review of Clinical Features, Risks, Biomarkers, and Outcomes--The 2017 J. Donald M. Gass Lecture.
    Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):109-120
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA.
    Conjunctival tumors encompass a broad range of diagnoses. The 3 most important malignant tumors include ocular surface squamous neoplasia (OSSN) (14%), melanoma (12%), and lymphoma (7%). Conjunctival malignancies are rarely found in children. Read More

    Salicylic acid peeling combined with vitamin C mesotherapy versus salicylic acid peeling alone in the treatment of mixed type melasma: a comparative study.
    J Cosmet Laser Ther 2017 Apr 7. Epub 2017 Apr 7.
    a İstanbul Medipol University Medical Faculty , Dermatology Department.
    Introduction: Melasma is a distressing condition for both dermatologists and patients. We evaluated the effectiveness of salicylic acid (SA) peel and vitamin C mesotherapy in the treatment of melasma.

    Materials And Methods: Fifty female patients were divided into two groups. Read More

    Coumestrol Down-Regulates Melanin Production in Melan-a Murine Melanocytes through Degradation of Tyrosinase.
    Biol Pharm Bull 2017 ;40(4):535-539
    Amorepacific R&D Corporation Center.
    Pigmentation reflects skin darkening caused by melanin production, but excessive melanin synthesis may cause problems, such as melasma, solar lentigo, dark spots, and freckles. Considerable effort has been devoted to alleviating these undesired symptoms through the development of safe and effective depigmenting agents. Coumestrol, a plant-derived natural isoflavone with an estrogen-like structure and actions, is known to have anti-aging ability, but its potential depigmenting efficacy has not been evaluated. Read More

    Efficacy and Safety of Tranexamic Acid in Melasma: A Meta-analysis and Systematic Review.
    Acta Derm Venereol 2017 Apr 4. Epub 2017 Apr 4.
    Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea.
    Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Read More

    Primary intranasal melanoma with brain invasion in a dog.
    Can Vet J 2017 Apr;58(4):391-396
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1 (Lemetayer); Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Al-Dissi, Tryon, MacDonald-Dickinson).
    A 6-year-old castrated male boxer dog with right-sided dark purulent nasal discharge and acute bilateral blindness was diagnosed on magnetic resonance imaging (MRI) and then on necropsy with primary nasal malignant melanoma that extended into the brain, as well as concurrent ocular melanosis. There was no evidence of metastasis in other organs. Read More

    Metastatic melanoma with features of blue nevus and tumoral melanosis identified during pembrolizumab therapy.
    JAAD Case Rep 2017 Mar 15;3(2):135-137. Epub 2017 Mar 15.
    Department of Dermatology, Penn State Health Hershey Medical Center, Hershey, Pennsylvania.
    Metastatic melanoma may exhibit clinical or histologic features of blue nevus. Pembrolizumab therapy is associated with regression and tumoral melanosis. We report on a man with widespread metastatic melanoma on pembrolizumab therapy in whom a blue-grey papule developed on the left side of his neck that clinically resembled a blue nevus and histologically showed features of both blue nevus and tumoral melanosis. Read More

    Melasma Associated with Topical Estrogen Cream.
    J Clin Aesthet Dermatol 2017 Feb 1;10(2):57-58. Epub 2017 Feb 1.
    Chairman, Department of Dermatology Herbert Wertheim College of Medicine, Florida International University, and Director, Greater Miami Skin and Laser Center, Mount Sinai Medical Center.
    A 47-year-old woman presented with hyperpigmented patches on her upper extremities. The patient had begun using a topical estrogen cream in the affected areas prior to noticing the hyperpigmentation. A diagnosis of melasma secondary to topical estrogen cream was made. Read More

    Melasma treatment: A novel approach using a topical agent that contains an anti-estrogen and a vascular endothelial growth factor inhibitor.
    Med Hypotheses 2017 Apr 3;101:1-5. Epub 2017 Feb 3.
    Department of Dermatology, University of California San Diego, San Diego, CA, United States. Electronic address:
    Melasma is an acquired disorder of pigmentation that presents with asymptomatic symmetric darkening of the face. The pathogenesis of this condition is multifactorial and influenced by several factors including female sex hormones, genetic predisposition and ultraviolet light exposure. The management of melasma is usually directed at more than one of the causative etiologic factors and often incorporates a combination of topical agents, with or without the addition of physical modalities. Read More

    Tumoral Melanosis Associated with Pembrolizumab-Treated Metastatic Melanoma.
    Cureus 2017 Feb 13;9(2):e1026. Epub 2017 Feb 13.
    Department of Dermatology, University of California, San Diego.
    Tumoral melanosis is a form of completely regressed melanoma that usually presents as darkly pigmented lesions suspicious for malignant melanoma. Histology reveals dense dermal and subcutaneous infiltration of melanophages. Pembrolizumab is an antibody directed against programmed death receptor-1 (PD1) and is frontline treatment for advanced melanoma. Read More

    [Correlation between chronic constipation and colorectal neoplasms].
    Zhonghua Wei Chang Wai Ke Za Zhi 2017 Mar;20(3):255-257
    Department of General Surgery, Center of Constipation Diagnosis and Treatment, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
    The correlation between chronic constipation and colorectal neoplasms has been arousing wide interest. There have been a number of domestic and international epidemiological and clinical researches focusing on this issue. Based on these researches, the correlation between constipation and colorectal neoplasms was studied from three aspects: constipation and colorectal polyps; constipation and colorectal cancer; melanosis coli (MC), laxatives and colorectal neoplasms. Read More

    Melanosis coli in patients with colon cancer.
    Prz Gastroenterol 2017 29;12(1):22-27. Epub 2016 Dec 29.
    Department of Gastroenterology and Metabolic Diseases, Medical University of Warsaw, Warsaw, Poland.
    Introduction: Melanosis coli is a benign lesion affecting the mucosa of the large intestine. There is a relationship between the presence of melanosis and anthraquinone laxative use. Melanosis coli is also observed in patients with colon cancer, but there is doubt whether these two conditions are related. Read More

    The Clinical and Histological Effect of a Low-Fluence Q-Switched 1,064-nm Neodymium: Yttrium-Aluminum-Garnet Laser for the Treatment of Melasma and Solar Lentigo in Asians: Prospective, Randomized, and Split-Face Comparative Study.
    Dermatol Surg 2017 Mar 21. Epub 2017 Mar 21.
    Departments of *Dermatology, and †Cosmetic Dermatology and Photomedicine, Wakayama Medical University, Wakayama, Japan.
    Background: The low-fluence Q-switched 1,064-nm neodymium:yttrium-aluminum-garnet laser (QSNYL) is popular for melasma treatment among Asians.

    Objective: This study was to evaluate the clinical and histological effects of the low-fluence QSNYL for treatment of melasma and solar lentigo.

    Materials And Methods: In this randomized split-face clinical study, 22 patients with melasma or solar lentigo received low-fluence QSNYL weekly for 10 sessions on one cheek. Read More

    Periorbital melasma: Hierarchical cluster analysis of clinical features in Asian patients.
    Skin Res Technol 2017 Mar 19. Epub 2017 Mar 19.
    Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
    Background: Studies have shown melasma lesions to be distributed across the face in centrofacial, malar, and mandibular patterns. Meanwhile, however, melasma lesions of the periorbital area have yet to be thoroughly described.

    Methods: We analyzed normal and ultraviolet light-exposed photographs of patients with melasma. Read More

    [Allogeneic cultured limbal epithelial transplantation: a clinical observation of its treatment effects on large conjunctival lesions].
    Zhonghua Yan Ke Za Zhi 2017 Mar;53(3):172-176
    Qingdao Eye Hospital, Shandong Eye Institute, Qingdao 266071, China.
    Objective: To introduce the surgical methods and investigate the treatment effects of conjunctival lesion resection combined with transplantation of allogeneic limbal epithelia cultured in vitro for treatment of varied large conjunctival lesions. Methods: A retrospective analysis of case data of the patients receiving transplantation of allogeneic limbal epithelia cultured in vitro for large conjunctival lesions at Qingdao Eye Hospital from January 2013 to December 2015 was conducted. Fresh donor corneal limbal epithelial tissues were obtained for cellular digestion and isolation. Read More

    Phacomatosis pigmentovascularis of cesioflammea type.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):54-56
    Instituto de Dermatologia Professor Rubem David Azulay - Santa Casa da Misericórdia do Rio de Janeiro (IDPRDA - SCMRJ) - Rio de Janeiro (RJ), Brazil.
    Phacomatosis pigmentovascularis is a rare syndrome, defined as the simultaneous presence of vascular nevus and melanocytic nevus in the same patient. We report the case of a 53-year-old woman presented with dermal melanosis and extensive vascular nevus, which match the typical manifestations of phakomatosis pigmetovascularis of cesioflammea type, according to Happle's classification. The rare occurrence of this genodermatosis and the clinical exuberance of the skin lesions motivated this case report. Read More

    Solution of Azelaic Acid (20%), Resorcinol (10%) and Phytic Acid (6%) Versus Glycolic Acid (50%) Peeling Agent in the Treatment of Female Patients with Facial Melasma.
    Adv Biomed Res 2017 22;6. Epub 2017 Feb 22.
    Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Melasma, a common acquired disorder of hyperpigmentation, especially in women, is often resistant to therapy. This study was aimed to evaluate the efficacy and safety of azelaic acid, resorcinol and phytic acid solution in chemical peeling of melasma in comparison to 50% glycolic acid.

    Materials And Methods: This clinical trial was performed, on 42 female patients with bilateral melasma. Read More

    Impression Cytology in a Series of Clinically Diagnosed Ocular Surface Melanocytic Lesions.
    J Ophthalmic Vis Res 2017 Jan-Mar;12(1):17-22
    Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
    Purpose: To report impression cytology (IC) results of clinically diagnosed ocular surface melanocytic lesions.

    Methods: Ten patients with a clinical diagnosis of an ocular surface melanocytic lesion underwent IC using cellulose acetate strips and Periodic acid Schiff-Papanicolaou staining. Excisional biopsy of lesions was performed in case of observing atypical cells on IC or at the patient's request, and excised specimens were subjected to histopathological analysis. Read More

    Tranexamic Acid in the Treatment of Melasma: A Review of the Literature.
    Am J Clin Dermatol 2017 Mar 10. Epub 2017 Mar 10.
    Department of Dermatology and Cutaneous Surgery, University of Miami Hospital, 1475 NW 12th Ave. Suite 2175, Miami, FL, 33136, USA.
    Melasma is a common acquired pigmentary disorder marked by irregular hyperpigmented macules or patches and most commonly occurs in women of darker skin color. It is a chronic often-relapsing condition that causes negative psychosocial effects in those affected. Current treatments such as hydroquinone, kojic acid, and retinoids, among others, demonstrate variable efficacy and side-effect profiles. Read More

    Melasma: systematic review of the systemic treatments.
    Int J Dermatol 2017 Feb 27. Epub 2017 Feb 27.
    Division of Dermatology, University of Toronto, Toronto, Ontario, Canada.
    Currently available treatment options for melasma include prevention of UV radiation, topical lightening agents, chemical peels, and light-based and laser therapies. However, none have shown effective and sustained results, with incomplete clearance and frequent recurrences. There has been increasing interest recently in oral medications and dietary supplements in improving melasma. Read More

    Soft palatal melanosis, a simple predictor for neoplasia in the upper aerodigestive tract in Japanese alcoholic men.
    Cancer Sci 2017 Feb 20. Epub 2017 Feb 20.
    Department of Health Promotion, National Institute of Public Health, 2-3-6 Minami, Wako, Saitama, 351-0104, Japan.
    Soft palatal melanosis can be detected by visual inspection during routine physical examination or even personally in a mirror. The aim of this study was to evaluate the association between squamous cell neoplasia in the upper aerodigestive tract (UAT) and the soft palatal melanosis. We reviewed digitalized records of high-quality endoscopic images of the soft palate of 1786 Japanese alcoholic men who underwent endoscopic screening. Read More

    Sun-protective behaviors in patients with cutaneous hyperpigmentation: A cross-sectional study.
    J Am Acad Dermatol 2017 May 16;76(5):841-846.e2. Epub 2017 Feb 16.
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts. Electronic address:
    Background: Disorders of hyperpigmentation are seen commonly in clinical practice. Despite numerous studies investigating sun-protective habits among healthy persons, little is known about these behaviors within patient populations with hyperpigmentation disorders.

    Objective: We sought to examine photo-protective behaviors and their associations in individuals with disorders of hyperpigmentation. Read More

    African ancestry is associated with facial melasma in women: a cross-sectional study.
    BMC Med Genet 2017 Feb 17;18(1):17. Epub 2017 Feb 17.
    Department of Dermatology, FMB-Unesp, Botucatu, SP, Brazil.
    Background: Melasma is a chronic acquired focal hypermelanosis affecting photoexposed areas, especially for women during fertile age. Several factors contribute to its development: sun exposure, sex steroids, medicines, and family history. Melanic pigmentation pathway discloses several SNPs in different populations. Read More

    [Primary malignant melanoma in the brain of a 7-month-old sheep (Ovis aries f. domestica)].
    Tierarztl Prax Ausg G Grosstiere Nutztiere 2017 Apr 15;45(2):108-111. Epub 2017 Feb 15.
    Dr. Dr. habil. Wolfram Breuer, Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit, Oberschleißheim, Veterinärstraße 2, 85764 Oberschleißheim, E-Mail:
    A case of malignant melanoma in a sheep's brain is described for the first time. In a 7-month-old sheep that had been euthanized due to ataxia, post-mortem and histopathologic examinations were performed. Both the brain and the calvarium were heavily infiltrated with neoplastic tissue. Read More

    Common Skin Conditions in Children: Neonatal Skin Lesions.
    FP Essent 2017 Feb;453:11-17
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

    Combined Jessner Solution and Trichloroacetic Acid Versus Trichloroacetic Acid Alone in the Treatment of Melasma in Dark-Skinned Patients.
    Dermatol Surg 2017 Feb 6. Epub 2017 Feb 6.
    Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt.
    Background: Melasma is a common challenging pigmentary skin disorder especially in dark-skinned females urging them to seek medical help. Many modalities of treatment are available, but none is satisfactory.

    Objective: To compare safety and efficacy of combined trichloroacetic acid (TCA) (20%-25%) and Jessner's solution versus TCA (20%-25%) alone in dark patients with melasma. Read More

    Anti-melasma codrug of retinoic acid assists cutaneous absorption with attenuated skin irritation.
    Eur J Pharm Biopharm 2017 May 1;114:154-163. Epub 2017 Feb 1.
    Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan; Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan; Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Kweishan, Taoyuan, Taiwan. Electronic address:
    Melasma treatment with combined retinoic acid (RA) and hydroquinone (HQ) usually causes unsatisfactory outcomes and safety concerns. This study attempted to evaluate the cutaneous absorption and skin tolerance of the codrug conjugated with RA and HQ via ester linkage. The codrug's permeation of the pig skin was estimated using Franz diffusion cell. Read More

    Immunohistochemical profiling including beta-catenin in conjunctival melanocytic lesions.
    Exp Mol Pathol 2017 Feb 1;102(2):198-202. Epub 2017 Feb 1.
    Department of Pathology, Division of Neuropathology, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA, United States. Electronic address:
    Conjunctival melanocytic lesions encompass a group of clinically diverse, benign to malignant, neoplasms that may contain overlapping histopathological features, making definitive diagnosis challenging in some cases. In this series, we compared multiple immunohistochemical (IHC) markers in 11 conjunctival nevi, 10 primary acquired melanosis (PAM) lesions, and 11 conjunctival melanomas. Immunostains included the melanocytic markers HMB-45 and Melan-A, as well as the proliferative marker Ki-67. Read More

    Pulsed alexandrite laser for treatment of melasma in Asian patients.
    J Cosmet Laser Ther 2017 Feb 2:1-5. Epub 2017 Feb 2.
    a Department of Dermatology , Chang Gung Memorial Hospital and Chang Gung University College of Medicine , Taoyuan , Taiwan.
    Background: Melasma is a common acquired facial hypermelanosis with irregular brownish macules and patches. The clinical course is often fluctuated and refractory to treatment. The present study was conducted to evaluate the efficacy and safety of pulsed alexandrite laser for the treatment of melasma. Read More

    Clinical efficacy of liposome-encapsulated Aloe vera on melasma treatment during pregnancy.
    J Cosmet Laser Ther 2017 Jan 31:1-7. Epub 2017 Jan 31.
    b Department of Medical Biotechnology , School of Advance Science in Medicine, Tehran University of Medical Sciences , Tehran , Iran.
    Background: Melasma is a challenging dermatological condition during pregnancy. The aim of this study was to determine the clinical efficacy of a topical liposome-encapsulated Aloe vera preparation, on melasma in pregnant women. In order to enhance the bioavailability of Aloe vera leaf gel extract (AGE), liposomes encapsulating Aloe vera were prepared and examined for their biochemical properties. Read More

    Retrospective analysis of the treatment of melasma lesions exhibiting increased vascularity with the 595-nm pulsed dye laser combined with the 1927-nm fractional low-powered diode laser.
    Lasers Surg Med 2017 Jan 13;49(1):20-26. Epub 2016 Apr 13.
    Dermatology and Laser Surgery Center, 6400 Fannin St. Suite 2720, Houston, Texas.
    Background: Melasma presents a significant challenge to laser surgeons. Aggressive treatments often result in rebound melasma or post-inflammatory pigmentary alteration. Recent reports suggest melasma pathogenesis may have a vascular component. Read More

    Tranexamic acid in treatment of melasma: A comprehensive review of clinical studies.
    Dermatol Ther 2017 Jan 30. Epub 2017 Jan 30.
    Department of Dermatology, Razi Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
    Melasma is a human melanogenesis dysfunction that results in localized, chronic acquired hyperpigmentation of the skin. It has a significant impact on appearance, causing psychosocial and emotional distress, and reducing the quality of life of the affected patients. Tranexamic acid (TA) is a plasmin inhibitor used to prevent abnormal fibrinolysis to reduce blood loss and exerts its effect by reversibly blocking lysine binding sites on plasminogen molecules, thus inhibiting plasminogen activator (PA) from converting plasminogen to plasmin. Read More

    The effects of hydroporation on melasma with anti-aging cocktail.
    J Cosmet Dermatol 2017 Jan 29. Epub 2017 Jan 29.
    Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
    Background: Jet-M is a device for epidermal peeling and is used to deliver substances by spraying air and microdroplets. Previously, a case was treated with a mixed solution of copper-GHK, oligo-hyaluronic acid, Rhodiola extract, tranexamic acid, and β-glucan. The results showed significant improvement of aged skin. Read More

    [Melanocytoma and meningeal melanocytosis, similar but different lesions].
    Cir Cir 2017 Jan 23. Epub 2017 Jan 23.
    Servicio de Patología, Hospital Juárez de México, Ciudad de México, México.
    Background: Meningeal melanomatosis is an extra-axial well-encapsulated malignant tumour with diffuse meningeal growth and dark coloration (due to high melanin contents), while meningeal melanocytoma is the focalized benign variant. Melanocytic lesions may be secondary to melanoma or be histologically benign, however, their diffuse nature makes them impossible to cure. Melanocytosis is a diffuse tumour that can form solitary extra-axial tumours, which invades the parenchyma and presents signs of malignancy with increased mitosis and Ki67, observed in 1 to 6% of immunopathological exams. Read More

    Clinical Features Differentiating Benign From Malignant Conjunctival Tumors in Children.
    JAMA Ophthalmol 2017 Mar;135(3):215-224
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
    Importance: Conjunctival tumors in children are usually benign and rarely malignant.

    Objective: To evaluate clinical features of conjunctival tumors in children by comparing benign tumors with their malignant counterparts.

    Design, Setting, And Participants: This retrospective case series reviewed 806 cases of conjunctival tumor in children (aged <21 years) who were evaluated at a tertiary referral center between November 1, 1975, and July 1, 2015. Read More

    CLINICAL PROFILE AND TRIGGERING FACTORS FOR ACQUIRED, BILATERAL NEVUS OF OTA-LIKE MACULES.
    Cutan Ocul Toxicol 2017 Jan 25:1-14. Epub 2017 Jan 25.
    a Affiliated Hospital of Nanjing University of Chinese Medicine , Nanjing , China.
    BACKGROUD Acquired, bilateral nevus of Ota-like macules (ABNOM) is one of the most common dermal melanocytoses. Although there are some literatures on ABNOM, its clinical features and etiopathogenetic factors have not been fully understood. OBJECTIVE To determine the prevalence and characteristics of ABNOM among the Chinese patients. Read More

    Primary cerebral malignant melanoma: A case report with literature review.
    Medicine (Baltimore) 2017 Jan;96(4):e5805
    aDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University bDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Dongcheng District, Beijing, P. R. China cDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Harvard University, Boston, MA dDepartment of Neurovascular Surgery, Chinese Armed Police General Hospital, Haidian District eDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Xuanwu District, Beijing, P. R. China.
    Primary intracranial melanomas are uncommon and constitute approximately 1% of all melanoma cases and 0.07% of all brain tumors. In nature, these primary melanomas are very aggressive and can spread to other organs. Read More

    Congenital Melanocytic Nevus Syndrome: A Case Series.
    Actas Dermosifiliogr 2017 Jan 19. Epub 2017 Jan 19.
    Servicio de Anatomía Patológica, Complejo Hospitalario de Toledo, Toledo, España.
    Congenital melanocytic nevus syndrome (CMNS) is the result of an abnormal proliferation of melanocytes in the skin and central nervous system caused by progenitor-cell mutations during embryonic development. Mutations in the NRAS gene have been detected in many of these cells. We present 5 cases of giant congenital melanocytic nevus, 3 of them associated with CMNS; NRAS gene mutation was studied in these 3 patients. Read More

    Patient and medical barriers preclude uptake of tamoxifen preventative therapy in women with a strong family history.
    Breast 2017 Apr 18;32:93-97. Epub 2017 Jan 18.
    Breast Tumor Stream, Victorian Comprehensive Cancer Centre, Australia; Department of Surgery, The University of Melbourne, Royal Melbourne Hospital, Australia; Familial Cancer Centre, The Royal Melbourne Hospital, Peter MacCallum Cancer Centre, Australia.
    Aims: To assess the eligibility, uptake and impediments to tamoxifen use in high-risk women attending a risk management clinic due to family history.

    Patients And Methods: All patients with a germline mutation in a cancer predisposing gene or at high genetic risk (based on family history) attending a Breast and Ovarian cancer risk management clinic from February 2014 to May 2015 received both verbal and written evidence-based information on preventive therapy and were recommended to consider endocrine prevention if not contraindicated. Endocrine therapy initiation, use and cessation were captured. Read More

    Nasal mucosal melanosis may act as a harbinger of melanoma: A case report.
    Allergy Rhinol (Providence) 2016 Jan;7(3):164-167
    Background: The progression from a benign pigmented lesion on the skin to cutaneous melanoma is better understood, and it could be presumed that a similar progression occurs with mucosal lesions. However, to our knowledge, there has never been documentation of melanosis transforming into melanoma over time.

    Objective: To describe a transformation of a mucosal melanosis into melanoma. Read More

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