10,133 results match your criteria Melasma

Carvacrol, citral and α-terpineol essential oil incorporated biodegradable films for functional active packaging of Pacific white shrimp.

Food Chem 2021 May 30;363:130252. Epub 2021 May 30.

Department of Packaging and Materials Technology, Faculty of Agro-Industry, Kasetsart University, 50 Ngam Wong Wan Rd., Latyao, Chatuchak, Bangkok 10900, Thailand; Center for Advanced Studies for Agriculture and Food, Kasetsart University, 50 Ngam Wong Wan Rd., Latyao, Chatuchak, Bangkok 10900, Thailand. Electronic address:

Biodegradable poly(butylene adipate terephthalate) and poly(lactic acid) (PBAT/PLA) blend films compounded with carvacrol, citral and α-terpineol essential oils (EOs) were produced for food packaging via blown-film extrusion. PBAT/PLA interacted with citral and α-terpineol via hydrogen bonding and carbonyl groups. Microstructures and barrier properties against water vapor and oxygen were modified depending on types and concentrations (3% and 6%) of EOs. Read More

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Efficacy and Safety of Topical Silymarin Versus Low Fluence 1064-nm Q Switched Nd:YAG Laser in the Treatment of Melasma: A Comparative Randomized Trial.

Lasers Surg Med 2021 Jun 8. Epub 2021 Jun 8.

Department of Dermatology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, 11651, Egypt.

Background And Objectives: The management of melasma is challenging and requires multiple uses of available therapeutic options. To compare the short-term efficacy and safety of topical silymarin and low fluence 1064-nm Q-switched ND:YAG laser for treatment of melasma with dermoscopic follow-up.

Study Design/materials And Methods: Fifty female patients with melasma were included in this study. Read More

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Case of Rapidly Expanding Conjunctival Malignant Melanoma Initially from Primary Acquired Melanosis Diagnosed 14 Years Earlier.

Int Med Case Rep J 2021 28;14:361-364. Epub 2021 May 28.

Department of Ophthalmology, Nara Medical University, Nara, Japan.

Primary acquired melanosis (PAM) of the conjunctiva is a potentially serious melanocytic lesion that can lead to the development of a melanoma. A 60-year-old woman noticed pigmentation of the conjunctiva of her left eye for more than 10 years. She underwent excisional biopsy combined with cryotherapy and was diagnosed with PAM without atypia by intraoperative consultation. Read More

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Microdermabrasion assisted delivery of glycolic acid 70% peel for the treatment of melasma in dark-skinned patients.

Dermatol Ther 2021 Jun 5:e15025. Epub 2021 Jun 5.

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University Hospitals, Assiut, Egypt.

Melasma is a disfiguring dermatologic condition and its treatment is still considered a challenge. To evaluate the efficacy and safety of microdermabrasion (MDA) combined with glycolic acid 70% (GA70%) peel versus GA70% alone in treating melasma in dark-skinned patients. This study included 30 female patients (skin type IV and V) with melasma. Read More

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PRAME Immunohistochemistry is Useful in the Evaluation of Conjunctival Melanomas, Nevi, and Primary Acquired Melanosis.

J Cutan Pathol 2021 Jun 4. Epub 2021 Jun 4.

Department of Surgery, Section of Ophthalmology, Geisel School of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Background: Many dermatopathologists find conjunctival melanocytic proliferations challenging because they are rare relative to their cutaneous counterparts and have nuanced morphology and nomenclature. PRAME immunohistochemistry has been widely adopted for distinguishing cutaneous nevi from melanoma, but limited data exist assessing its utility in evaluating conjunctival specimens. In particular, it is uncertain whether it can predict the risk of melanoma progression in primary acquired melanosis (PAM). Read More

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An open-label, investigator-initiated, single-center, prospective, pilot clinical study to evaluate the efficacy of a skin whitening serum applied twice daily combined with a spot-preventing SPF50+ sunscreen in healthy female subjects with melasma hyperpigmentation.

J Cosmet Dermatol 2021 Jun 4. Epub 2021 Jun 4.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Background: Melasma is a common skin disorder characterized by alterations in normal skin pigmentation. The objective was to evaluate the efficacy and safety of a skin whitening serum containing niacinamide, hydroxyphenoxy propionic acid, dipotassium glycyrrhizate, glycolic acid and 4-n-butylresorcinol applied twice daily combined with a spot-preventing SPF50+ sunscreen for treatment of melasma.

Methods: Twelve healthy Caucasian women with melasma (Fitzpatrick skin types II-IV) were enrolled in this pilot clinical study. Read More

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Dual Toning Method with the Combination of Picosecond and Microsecond Nd:YAG in Refractory Melasma Unresponsive to Picosecond Alone.

J Cutan Aesthet Surg 2021 Jan-Mar;14(1):101-106

Department of Dermatology, Aalborg University Hospital, Aalborg, Denmark.

Background: Melasma is an acquired and treatment-resistant aging facial skin condition prevalent among the older Asian females. The Q-switched toning laser is the most widely used for the treatment of moderate to severe melasma in Asia. Recently, the picosecond laser has been introduced for various pigmentary disorders such as melasma. Read More

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Randomized, double-blind, placebo controlled split face trial of the efficacy of tranexamic acid by drug delivery through microneedling in the treatment of melasma.

J Cosmet Dermatol 2021 Jun 2. Epub 2021 Jun 2.

Department of Dermatology of Hospital, Universitário Evangélico Mackenzie, Curitiba, Paraná, Brazil.

Background: Melasma is a prevalent skin pigmentation disorder that is difficult to treat. Tranexamic acid (TA) is a potential agent, but there are few studies on its effectiveness under the transdermal route (drug delivery - Dd). One of these Dd pathways is through microneedling, which seems to be effective itself. Read More

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Trends in Use of Prescription Skin Lightening Creams.

Int J Environ Res Public Health 2021 May 25;18(11). Epub 2021 May 25.

Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA.

The desire for an even skin tone pervades all cultures and regions of the world. Uniform skin color is considered a sign of beauty and youth. Pigmentation abnormalities can arise idiopathically with genetic predetermination, with injury and environmental exposures, and with advancing age, and can, therefore, be distressing to patients, leading them to seek a variety of treatments with professional assistance. Read More

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Inhibitory Effect of Olive Phenolic Compounds Isolated from Olive Oil By-Product on Melanosis of Shrimps.

Antioxidants (Basel) 2021 May 5;10(5). Epub 2021 May 5.

Department of Food Phytochemistry, Instituto de la Grasa (Spanish National Research Council, CSIC), Pablo Olavide University, Building 46, Ctra de Utrera km 1, 41013 Seville, Spain.

Melanosis is an unsolved problem of the crustacean industry and the cause of great loss of value. This study investigates the effect of two potent, natural antioxidants isolated from olive waste (hydroxytyrosol, HT and 3,4-dihydroxyphenylglycol, DHPG) and three novel HT-derivatives containing selenium and sulfur (dihydroxytyrosyl diselenide, -hydroxytyrosyl selenourea, and -hydroxytyrosyl thiourea) on the prevention of melanosis in Atlantic ditch shrimp () during refrigerated storage. These results clearly demonstrate the positive inhibitory effect of DHPG and dihydroxytyrosyl diselenide on delaying melanosis in vivo, although this effect was not dose dependent. Read More

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Cutaneous Manifestations of Diabetes.

Med Clin North Am 2021 Jul;105(4):681-697

Department of Dermatology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Diabetes mellitus is a significant worldwide health concern and cutaneous manifestations are common. This review describes characteristic skin findings of diabetes, general skin findings related to diabetes, and findings related to diabetes treatment with a focus on clinical presentation, diagnosis, pathophysiology, epidemiology, and treatment. As the prevalence of diabetes continues to rise, cutaneous manifestations of diabetes mellitus likely will be encountered more frequently by physicians in all disciplines including dermatologists and primary care physicians. Read More

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Imaging and clinical features of neurocutaneous melanosis in the pediatric population.

Curr Med Imaging 2021 05 26. Epub 2021 May 26.

Department of Biomedical and Dental Sciences and of Morphofunctional Imaging, University of Messina, Italy.

Background: Neurocutaneous melanosis (NCM) is a rare nonfamilial phakomatosis characterized by the presence of congenital melanocytic nevi and abnormal melanocytes infiltration of the leptomeninges.

Objective & Methods: This paper shows the importance of early diagnosis and the most important imaging features of the disease on CT and MR scans. PubMed database was searched from January 1972 to September 2020. Read More

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Study of autologous platelet-rich-plasma versus its combination with intense pulsed light in treatment of melasma.

Dermatol Ther 2021 May 26:e15008. Epub 2021 May 26.

The Department of Dermatology and Venereology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Melasma is a common acquired hypermelanosis of variably successful therapies with frequent relapse. Platelet-rich-plasma (PRP) is a promising treatment in melasma, alone or combined with other treatments. We evaluated efficacy of autologous PRP in melasma treatment and the effect of combined intense pulsed light (IPL). Read More

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Use of Hyaluronic acid fillers in treatment of peri ocular melanosis induced by shadow effect of tear trough deformity: Anatomical considerations, patient satisfaction and management of complications.

J Cosmet Dermatol 2021 May 24. Epub 2021 May 24.

Department of Dermatology and STD, VMMC and Safdarjung Hospital, Delhi, India.

Background: Periocular melanosis (POM) due to shadow effect of tear trough deformity (TT )does not respond to the conventional treatment modalities. Hyaluronic acid(HA) fillers are a favourable treatment modality . This area is a high-risk for injectables due to its unique anatomy . Read More

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Comparing the Efficacy of Patelet-rich Plasma (PRP) versus Tranexamic Acid (4mg/mL) as Intradermal Treatments of Melasma.

J Coll Physicians Surg Pak 2021 May;30(5):502-505

Department of Dermatology, Sheikh Zaid Hospital, Rahim Yar Khan, Pakistan.

Objective: To compare the efficacy of intradermal platelet-rich-plasma vs. intradermal tranexamic acid in treatment of melasma.

Study Design: Non-randomised controlled trial. Read More

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Giant cerebriform melanocytic nevus of the scalp: A case report.

Clin Case Rep 2021 May 5;9(5):e03807. Epub 2021 May 5.

School of Medicine Isfahan University of Medical Sciences Isfahan Iran.

Giant melanocytic nevus is a rare condition caused by benign proliferation of melanocytes. There is a slight risk of malignancy in these lesions which should be noticed especially when they become larger. GCMN can be removed by plastic surgery. Read More

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Postinflammatory hyperpigmentation: protocol for development of a core outcome set for clinical trials.

Arch Dermatol Res 2021 May 21. Epub 2021 May 21.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, 676 N Saint Clair Street, Suite 1600, Chicago, IL, 60611, USA.

Postinflammatory hyperpigmentation (PIH) is a disorder of pigmentation that is a common presenting complaint, especially in individuals with skin of color. It is associated with a significant psychological burden and decrement of quality of life. Management options include photoprotection, topical lightening agents, and lasers and energy devices. Read More

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Bilateral idiopathic choroidal hyperpigmentation.

Eur J Ophthalmol 2021 May 20:11206721211019573. Epub 2021 May 20.

Medical Retina and Vitreoretinal Surgery, University of Pittsburgh School of Medicine, Pittsburg, PA, USA.

Purpose: To report a series of cases showing bilateral circumpapillary hyperpigmentation on routine fundus examination.

Methods: In this observational case series, three patients showing bilateral circumpapillary hyperpigmentation on routine fundus examination were included. Multimodal retinal imaging was done for these cases. Read More

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Platelet-rich plasma is a promising therapy for melasma.

J Cosmet Dermatol 2021 May 19. Epub 2021 May 19.

Department of Dermatology, Government Medical College and Hospital, Chandigarh, India.

Introduction: Platelet-rich plasma (PRP) is an autologous blood product which has recently been used in multiple spheres of dermatology including facial rejuvenation, androgenetic alopecia, acne scars, and wound healing. Its use in melasma is comparatively an understudied topic.

Material And Methods: An extensive systematic literature search of the PubMed electronic database and Cochrane central register of controlled trials was done using the keywords "platelet rich plasma" and "melasma" in the title. Read More

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Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs. 4% hydroquinone cream for facial melasma: an evaluator-blinded, randomized controlled trial.

J Eur Acad Dermatol Venereol 2021 May 14. Epub 2021 May 14.

Departamento de Dermatologia e Radioterapia, FMB-Unesp, Botucatu, Brazil.

Background: Melasma can be refractory to treatment, and relapses are frequent. Thiamidol is a new potent tyrosinase inhibitor that has been found effective as a cosmeceutical for the depigmenting of melasma.

Objective: This study compared the efficacy and tolerability of topical 0. Read More

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Melasma: A Condition of Asian Skin.

Cureus 2021 Apr 10;13(4):e14398. Epub 2021 Apr 10.

Medical Education, Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Davie, USA.

Melasma is a benign yet psychologically debilitating skin condition that is prevalent among women of darker phenotypes, and particularly in Asian women. This potentially preventable condition can lead to skin discoloration that is hard to treat and can frequently recur. This review aims to (1) highlight the pathophysiology of melasma, (2) describe its important risk factors, and (3) identify prevention methods, available treatment options, and potential complications of melasma. Read More

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Clinical and Histopathological Features of Corneal Primary Acquired Melanosis and Melanoma.

Ocul Oncol Pathol 2021 Mar 21;7(2):103-107. Epub 2021 Jan 21.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.

Aim: The aim of this study is to describe the clinical and pathologic features of corneal primary acquired melanosis (PAM) and melanoma.

Methods: We describe 3 cases in total: two cases of corneal melanomas and 1 case of corneal PAM. The eyes were processed routinely for histopathological examination. Read More

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Tape stripping and lipidomics reveal skin surface lipid abnormity in female melasma.

Pigment Cell Melanoma Res 2021 May 11. Epub 2021 May 11.

Department of Dermatology, Hangzhou Third People's Hospital, Affiliated Hangzhou Dermatology Hospital of Zhejiang University School of Medicine, Hangzhou, China.

The skin barrier of melasma is involved in the pathogenesis of melasma. Previous studies have shown that there are differences in the expression of epidermal lipid genes in melasma, but little is known about the epidermis lipid composition of melasma. Compared with the non-lesional skin, the content of total lipids, phosphatidic acid, phosphatidylserine, and ceramide (Cer) increased significantly in the lesional skin. Read More

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Intradermal tranexamic acid microinjections: a novel treatment option for erythematotelangiectatic rosacea.

J Cosmet Dermatol 2021 May 10. Epub 2021 May 10.

Department of Dermatology, Charles Nicolle Hospital, Tunis, Tunisia.

Background: Treatment options for erythematotelangiectatic rosacea (ETR) are still scarce. Tranexamic acid (TXA) is an antifibrinolytic drug that was recently used for the treatment of ETR.

Aims: To evaluate the efficacy and safety of intradermal microinjections of TXA for ETR. Read More

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The formulation and efficacy of topical in treating Melasma: a randomized double-blind, placebo-controlled trial.

J Complement Integr Med 2021 May 10. Epub 2021 May 10.

Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Objectives: An acquired melanin-related hyperpigmentation that occurs in sun exposure areas is Melasma which presents as gray-brown ridges and macules with prominent margins on the skin. The aim of this assay was to assess the formulation and efficacy of topical among Melasma patients.

Methods: This study was a 30 days double-blind, randomized clinical trial in Melasma with a placebo group. Read More

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Efficacy and safety of tranexamic acid in the treatment of adult melasma: An updated meta-analysis of randomized controlled trials.

J Clin Pharm Ther 2021 May 7. Epub 2021 May 7.

Department of Orthopedics surgery, West China Hospital, Sichuan University, Chengdu, China.

What Is Known And Objective: Tranexamic acid (TXA) is a novel treatment option for melasma; however, no consensus exists on its use. This study evaluates the efficacy and safety of TXA for melasma.

Methods: A comprehensive literature review was conducted to search for randomized controlled trials comparing TXA alone, TXA as adjuvant to routine treatment and placebo. Read More

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Assessment of Patients with Periorbital Melanosis for Hyperinsulinemia and Insulin Resistance.

Indian Dermatol Online J 2021 Mar-Apr;12(2):244-249. Epub 2021 Mar 2.

Department of Dermatology, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.

Background: Periorbital melanosis (PM) is one of the most common dermatological condition seen in routine practice. Several cutaneous markers such as acanthosis nigricans have been associated with insulin resistance (IR). However, the association of PM with IR needs to be substantiated. Read More

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Psychosocial burden of lichen planus pigmentosus is similar to vitiligo, but greater than melasma: A cross-sectional study from a tertiary-care center in north India.

Indian J Dermatol Venereol Leprol 2021 May-Jun;87(3):341-347

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

Background: Lichen planus pigmentosus can have a negative impact on the quality of life; however, this has not been studied in detail.

Objectives: To study the quality of life in patients with lichen planus pigmentosus and compare it with patients with vitiligo and melasma.

Methods: This was a cross-sectional study conducted in a tertiary-care center in north India from January 2018 to May 2019. Read More

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October 2019

Cerebellar amelanotic melanoma can mimic cerebellar abscess in a pediatric case of neurocutaneous melanosis.

Clin Case Rep 2021 Apr 12;9(4):1999-2006. Epub 2021 Feb 12.

Department of Biomedical and Dental Sciences and of Morphofunctional Imaging University of Messina Messina Italy.

Neurocutaneous melanosis (NCM) is a rare phakomatosis that may be associated with intracerebral masses. The differential diagnosis of intracerebral masses in NCM is often challenging and should include pigmented and nonpigmented lesions. Read More

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