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    The first transepidermal transplantation of non-cultured epidermal suspension using a dermarolling system in vitiligo: A sequential histological and clinical study.
    Pigment Cell Melanoma Res 2017 May 19. Epub 2017 May 19.
    Vitiligo Melasma Research Association, 2, Corniche de la Meyjande, Lacanau, 33680, France.
    The current methods for melanocyte delivery to depigmented skin are invasive and often require sophisticated approaches. Here we describe a promising simple and minimally invasive technique based on the dermarolling system. The technique involves preparation of a keratinocyte/melanocyte suspension prepared by trypsinization from a non-lesioned part of a patient's scalp skin and transepidermal delivery using a dermaroller equipped with 0. Read More

    Development of a quantitative assessment method of pigmentary skin disease using ultraviolet optical imaging.
    Skin Res Technol 2017 May 21. Epub 2017 May 21.
    Research Institute for Skin Image, College of Medicine, Korea University, Seoul, South Korea.
    Background/purpose: The visual scoring method has been used as a subjective evaluation of pigmentary skin disorders. Severity of pigmentary skin disease, especially melasma, is evaluated using a visual scoring method, the MASI (melasma area severity index). This study differentiates between epidermal and dermal pigmented disease. Read More

    Epidemiology and Predisposing Factors for Erythema Toxicum Neonatorum and Transient Neonatal Pustular: A Multicenter Study.
    Pediatr Dermatol 2017 May 25. Epub 2017 May 25.
    Department of Dermatology, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
    Background/objectives: Erythema toxicum neonatorum (ETN) and transient neonatal pustular melanosis (TNPM) are benign pustular skin conditions that are relatively common in newborns, but the predisposing factors for these conditions are unknown. Our goal was to verify the prevalence of ETN and TNPM and their predisposing factors in a large sample of neonates.

    Methods: In this prospective 1-year multicenter study, 2,831 neonates (age ≤72 hours) born in southern Brazil were randomized to undergo skin examination by a dermatologist. Read More

    Eosinophilic annular erythema is clinically characterized by central pigmentation reflecting basal melanosis: A clinicopathological study of 10 cases.
    J Eur Acad Dermatol Venereol 2017 May 22. Epub 2017 May 22.
    Department of Dermatology, Hokkaido University Graduate School of Medicine, N15W7, Kita-ku, Sapporo, Japan.
    Background: Eosinophilic annular erythema (EAE) has been proposed as a clinical entity to describe annular skin lesions associated with tissue eosinophilia. However, systematic investigations on the histopathology of EAE have not been performed, and useful histopathological findings for diagnosis of EAE remain unknown.

    Objective: The aim of this study was to investigate the clinicopathological features of EAE METHODS: We retrospectively studied 10 patients at our hospital during a 5-year span who clinically showed annular or figurate lesions and histopathologically exhibited eosinophilic infiltration in the dermis. Read More

    Successful Treatment of Becker's Nevus With Long-Pulsed 1064nm Nd:YAG and 755nm Alexandrite Laser and Review of the Literature.
    J Cosmet Laser Ther 2017 May 12. Epub 2017 May 12.
    b Gateway Aesthetic Institute & Laser Center , Salt Lake City , UT.
    Background: Becker's Nevus is an aesthetically troublesome condition secondary to hyperpigmentation and hypertrichosis. Although several lasers have been employed with varying degrees of success, the exact devices and treatment parameters have yet to be elucidated.

    Objective: To assess the combination Nd:Yag and alexandrite laser as a safe and efficacious treatment for Becker's Nevus. Read More

    A review of laser and light therapy in melasma.
    Int J Womens Dermatol 2017 Mar 21;3(1):11-20. Epub 2017 Mar 21.
    Department of Dermatology, Palo Alto Medical Foundation, Sunnyvale, California.
    Melasma is a dysregulation of the homeostatic mechanisms that control skin pigmentation and excess pigment is produced. Traditional treatment approaches with topical medications and chemical peels are commonly used but due to the refractory and recurrent nature of melasma, patients often seek alternative treatment strategies such as laser and light therapy. Several types of laser and light therapy have been studied in the treatment of melasma. Read More

    Updates in the understanding and treatments of skin & hair disorders in women of color.
    Int J Womens Dermatol 2017 Mar 16;3(1 Suppl):S21-S37. Epub 2017 Feb 16.
    Department of Dermatology, Howard University College of Medicine, Washington, District of Columbia.
    Skin of color comprises a diverse and expanding population of individuals. In particular, women of color represent an increasing subset of patients who frequently seek dermatologic care. Acne, melasma, and alopecia are among the most common skin disorders seen in this patient population. Read More

    Efficacy of functional microarray of microneedles combined with topical tranexamic acid for melasma: A randomized, self-controlled, split-face study.
    Medicine (Baltimore) 2017 May;96(19):e6897
    aDepartment of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing bSuzhou NanoMED skincare Inc, Suzhou, China.
    To evaluate the efficacy of a functional microarray of microneedles (MNs) plus topical tranexamic acid (TA) for melasma in middle-aged women in China.Thirty female subjects with melasma were enrolled in this study. The left or right side of the face was chosen randomly to be pretreated with a functional microarray of MNs, followed by topical 0. Read More

    Novel regulation of melanogenesis by adiponectin via the AMPK/CRTC pathway.
    Pigment Cell Melanoma Res 2017 May 8. Epub 2017 May 8.
    Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    Several studies observed that adiponectin, an important adipokine that improves glucose metabolism by regulating AMP-activated protein kinase (AMPK) signaling, is dermatologically beneficial. In our recent microarray data, we found that adiponectin expression was lower in lesional skin than in non-lesional skin of melasma patients. Given that AMPK is a key adiponectin signaling mediator, we investigated the role of adiponectin and AICAR, a cell-permeable AMPK activator, in melanogenesis. Read More

    Oral pigmentations in physiologic conditions, post inflammatory affections and systemic diseases.
    G Ital Dermatol Venereol 2017 Apr 19. Epub 2017 Apr 19.
    Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy -
    Melanocytes are found throughout the oral mucosa but usually go unnoticed because of their relatively low level of pigment production. When focally or generally active in pigment production or proliferation they may be responsible for several affections in the oral mucosae ranging from physiologic pigmentation, systemic diseases to malignant neoplasms. The diagnosis of oral pigmentations (OP) is usually challenging for the physician, but a careful examination of the oral cavity may reveal the first manifestation of underlying systemic diseases. Read More

    Effect of catechin and its derivatives on inhibition of polyphenoloxidase and melanosis of Pacific white shrimp.
    J Food Sci Technol 2017 Apr 24;54(5):1098-1107. Epub 2017 Feb 24.
    Department of Food Science and Agricultural Chemistry, McGill University (Macdonald Campus), 21,111 Lakeshore Road, Sainte-Anne-de-Bellevue, QC H9X 3V9 Canada.
    This study aimed to investigate the effect of tea catechin (C) and 4 of its derivatives on the Pacific white shrimp PPO inhibition and melanosis during refrigerated storage. Epigallocatechin gallate (EGCG) exhibited the highest inhibition towards PPO, followed by C. Inhibitory activity of all compounds tested was in a dose dependent manner (0. Read More

    Supratentorial intermediate grade meningeal melanocytoma with intratumoral bleed in the background of neurocutaneous melanosis: Report of an unusual case and review of literature.
    Asian J Neurosurg 2017 Jan-Mar;12(1):98-102
    Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
    Primary melanocytic tumours of the central nervous system (CNS) are rare. According to the WHO classification (2007), these tumours include diffuse leptomeningeal melanosis, melanomatosis, melanocytoma, and primary CNS melanoma. Meningeal melanocytoma, most commonly seen in the infratentorial compartment and cervical spinal cord, is a benign primary melanocytic neoplasm. Read More

    Microneedling in All Skin Types: A Review.
    J Drugs Dermatol 2017 Apr;16(4):308-313

    INTRODUCTION: Microneedling procedures are growing in popularity for a wide variety of skin conditions. This paper comprehensively reviews the medical literature regarding skin needling efficacy and safety in all skin types and in multiple dermatologic conditions.

    METHODS: A PubMed literature search was conducted in all languages without restriction and bibliographies of relevant articles reviewed. Read More


    Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma: Case report.
    Medicine (Baltimore) 2017 Apr;96(15):e6470
    aDepartment of Dermatology, Venereology and Allergology, Wroclaw Medical University bDepartment of Pathomorphology, Wroclaw Medical University, Wroclaw, Poland.
    Rationale: Diffuse melanosis cutis (DMC) is a very rare sign of malignant melanoma progression. The condition usually develops after approximately one year from melanoma diagnosis in a patient with metastatic tumors and after anticancer treatment with cytostatic medications.

    Patient Concerns: A 72-year old Caucasian man was admitted to the Department of Dermatology with DMC for 4 months and the history of two melanomas treated surgically 30 years and 9 months before present hospitalization. Read More

    Conjunctival Tumors: Review of Clinical Features, Risks, Biomarkers, and Outcomes--The 2017 J. Donald M. Gass Lecture.
    Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):109-120
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA.
    Conjunctival tumors encompass a broad range of diagnoses. The 3 most important malignant tumors include ocular surface squamous neoplasia (OSSN) (14%), melanoma (12%), and lymphoma (7%). Conjunctival malignancies are rarely found in children. Read More

    Salicylic acid peeling combined with vitamin C mesotherapy versus salicylic acid peeling alone in the treatment of mixed type melasma: A comparative study.
    J Cosmet Laser Ther 2017 Apr 7:1-6. Epub 2017 Apr 7.
    a Medical Faculty, Dermatology Department , School of Medicine, İstanbul Medipol University , Istanbul , Turkey.
    Introduction: Melasma is a distressing condition for both dermatologists and patients. We evaluated the effectiveness of salicylic acid (SA) peel and vitamin C mesotherapy in the treatment of melasma.

    Materials And Methods: Fifty female patients were divided into two groups. Read More

    Coumestrol Down-Regulates Melanin Production in Melan-a Murine Melanocytes through Degradation of Tyrosinase.
    Biol Pharm Bull 2017 ;40(4):535-539
    Amorepacific R&D Corporation Center.
    Pigmentation reflects skin darkening caused by melanin production, but excessive melanin synthesis may cause problems, such as melasma, solar lentigo, dark spots, and freckles. Considerable effort has been devoted to alleviating these undesired symptoms through the development of safe and effective depigmenting agents. Coumestrol, a plant-derived natural isoflavone with an estrogen-like structure and actions, is known to have anti-aging ability, but its potential depigmenting efficacy has not been evaluated. Read More

    Efficacy and Safety of Tranexamic Acid in Melasma: A Meta-analysis and Systematic Review.
    Acta Derm Venereol 2017 Apr 4. Epub 2017 Apr 4.
    Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea.
    Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Read More

    Primary intranasal melanoma with brain invasion in a dog.
    Can Vet J 2017 Apr;58(4):391-396
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1 (Lemetayer); Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Al-Dissi, Tryon, MacDonald-Dickinson).
    A 6-year-old castrated male boxer dog with right-sided dark purulent nasal discharge and acute bilateral blindness was diagnosed on magnetic resonance imaging (MRI) and then on necropsy with primary nasal malignant melanoma that extended into the brain, as well as concurrent ocular melanosis. There was no evidence of metastasis in other organs. Read More

    Metastatic melanoma with features of blue nevus and tumoral melanosis identified during pembrolizumab therapy.
    JAAD Case Rep 2017 Mar 15;3(2):135-137. Epub 2017 Mar 15.
    Department of Dermatology, Penn State Health Hershey Medical Center, Hershey, Pennsylvania.
    Metastatic melanoma may exhibit clinical or histologic features of blue nevus. Pembrolizumab therapy is associated with regression and tumoral melanosis. We report on a man with widespread metastatic melanoma on pembrolizumab therapy in whom a blue-grey papule developed on the left side of his neck that clinically resembled a blue nevus and histologically showed features of both blue nevus and tumoral melanosis. Read More

    Melasma Associated with Topical Estrogen Cream.
    J Clin Aesthet Dermatol 2017 Feb 1;10(2):57-58. Epub 2017 Feb 1.
    Chairman, Department of Dermatology Herbert Wertheim College of Medicine, Florida International University, and Director, Greater Miami Skin and Laser Center, Mount Sinai Medical Center.
    A 47-year-old woman presented with hyperpigmented patches on her upper extremities. The patient had begun using a topical estrogen cream in the affected areas prior to noticing the hyperpigmentation. A diagnosis of melasma secondary to topical estrogen cream was made. Read More

    Melasma treatment: A novel approach using a topical agent that contains an anti-estrogen and a vascular endothelial growth factor inhibitor.
    Med Hypotheses 2017 Apr 3;101:1-5. Epub 2017 Feb 3.
    Department of Dermatology, University of California San Diego, San Diego, CA, United States. Electronic address:
    Melasma is an acquired disorder of pigmentation that presents with asymptomatic symmetric darkening of the face. The pathogenesis of this condition is multifactorial and influenced by several factors including female sex hormones, genetic predisposition and ultraviolet light exposure. The management of melasma is usually directed at more than one of the causative etiologic factors and often incorporates a combination of topical agents, with or without the addition of physical modalities. Read More

    Tumoral Melanosis Associated with Pembrolizumab-Treated Metastatic Melanoma.
    Cureus 2017 Feb 13;9(2):e1026. Epub 2017 Feb 13.
    Department of Dermatology, University of California, San Diego.
    Tumoral melanosis is a form of completely regressed melanoma that usually presents as darkly pigmented lesions suspicious for malignant melanoma. Histology reveals dense dermal and subcutaneous infiltration of melanophages. Pembrolizumab is an antibody directed against programmed death receptor-1 (PD1) and is frontline treatment for advanced melanoma. Read More

    [Correlation between chronic constipation and colorectal neoplasms].
    Zhonghua Wei Chang Wai Ke Za Zhi 2017 Mar;20(3):255-257
    Department of General Surgery, Center of Constipation Diagnosis and Treatment, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
    The correlation between chronic constipation and colorectal neoplasms has been arousing wide interest. There have been a number of domestic and international epidemiological and clinical researches focusing on this issue. Based on these researches, the correlation between constipation and colorectal neoplasms was studied from three aspects: constipation and colorectal polyps; constipation and colorectal cancer; melanosis coli (MC), laxatives and colorectal neoplasms. Read More

    Melanosis coli in patients with colon cancer.
    Prz Gastroenterol 2017 29;12(1):22-27. Epub 2016 Dec 29.
    Department of Gastroenterology and Metabolic Diseases, Medical University of Warsaw, Warsaw, Poland.
    Introduction: Melanosis coli is a benign lesion affecting the mucosa of the large intestine. There is a relationship between the presence of melanosis and anthraquinone laxative use. Melanosis coli is also observed in patients with colon cancer, but there is doubt whether these two conditions are related. Read More

    The Clinical and Histological Effect of a Low-Fluence Q-Switched 1,064-nm Neodymium: Yttrium-Aluminum-Garnet Laser for the Treatment of Melasma and Solar Lentigo in Asians: Prospective, Randomized, and Split-Face Comparative Study.
    Dermatol Surg 2017 Mar 21. Epub 2017 Mar 21.
    Departments of *Dermatology, and †Cosmetic Dermatology and Photomedicine, Wakayama Medical University, Wakayama, Japan.
    Background: The low-fluence Q-switched 1,064-nm neodymium:yttrium-aluminum-garnet laser (QSNYL) is popular for melasma treatment among Asians.

    Objective: This study was to evaluate the clinical and histological effects of the low-fluence QSNYL for treatment of melasma and solar lentigo.

    Materials And Methods: In this randomized split-face clinical study, 22 patients with melasma or solar lentigo received low-fluence QSNYL weekly for 10 sessions on one cheek. Read More

    Periorbital melasma: Hierarchical cluster analysis of clinical features in Asian patients.
    Skin Res Technol 2017 Mar 19. Epub 2017 Mar 19.
    Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
    Background: Studies have shown melasma lesions to be distributed across the face in centrofacial, malar, and mandibular patterns. Meanwhile, however, melasma lesions of the periorbital area have yet to be thoroughly described.

    Methods: We analyzed normal and ultraviolet light-exposed photographs of patients with melasma. Read More

    [Allogeneic cultured limbal epithelial transplantation: a clinical observation of its treatment effects on large conjunctival lesions].
    Zhonghua Yan Ke Za Zhi 2017 Mar;53(3):172-176
    Qingdao Eye Hospital, Shandong Eye Institute, Qingdao 266071, China.
    Objective: To introduce the surgical methods and investigate the treatment effects of conjunctival lesion resection combined with transplantation of allogeneic limbal epithelia cultured in vitro for treatment of varied large conjunctival lesions. Methods: A retrospective analysis of case data of the patients receiving transplantation of allogeneic limbal epithelia cultured in vitro for large conjunctival lesions at Qingdao Eye Hospital from January 2013 to December 2015 was conducted. Fresh donor corneal limbal epithelial tissues were obtained for cellular digestion and isolation. Read More

    Phacomatosis pigmentovascularis of cesioflammea type.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):54-56
    Instituto de Dermatologia Professor Rubem David Azulay - Santa Casa da Misericórdia do Rio de Janeiro (IDPRDA - SCMRJ) - Rio de Janeiro (RJ), Brazil.
    Phacomatosis pigmentovascularis is a rare syndrome, defined as the simultaneous presence of vascular nevus and melanocytic nevus in the same patient. We report the case of a 53-year-old woman presented with dermal melanosis and extensive vascular nevus, which match the typical manifestations of phakomatosis pigmetovascularis of cesioflammea type, according to Happle's classification. The rare occurrence of this genodermatosis and the clinical exuberance of the skin lesions motivated this case report. Read More

    Solution of Azelaic Acid (20%), Resorcinol (10%) and Phytic Acid (6%) Versus Glycolic Acid (50%) Peeling Agent in the Treatment of Female Patients with Facial Melasma.
    Adv Biomed Res 2017 22;6. Epub 2017 Feb 22.
    Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Melasma, a common acquired disorder of hyperpigmentation, especially in women, is often resistant to therapy. This study was aimed to evaluate the efficacy and safety of azelaic acid, resorcinol and phytic acid solution in chemical peeling of melasma in comparison to 50% glycolic acid.

    Materials And Methods: This clinical trial was performed, on 42 female patients with bilateral melasma. Read More

    Impression Cytology in a Series of Clinically Diagnosed Ocular Surface Melanocytic Lesions.
    J Ophthalmic Vis Res 2017 Jan-Mar;12(1):17-22
    Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
    Purpose: To report impression cytology (IC) results of clinically diagnosed ocular surface melanocytic lesions.

    Methods: Ten patients with a clinical diagnosis of an ocular surface melanocytic lesion underwent IC using cellulose acetate strips and Periodic acid Schiff-Papanicolaou staining. Excisional biopsy of lesions was performed in case of observing atypical cells on IC or at the patient's request, and excised specimens were subjected to histopathological analysis. Read More

    Tranexamic Acid in the Treatment of Melasma: A Review of the Literature.
    Am J Clin Dermatol 2017 Jun;18(3):373-381
    Department of Dermatology and Cutaneous Surgery, University of Miami Hospital, 1475 NW 12th Ave. Suite 2175, Miami, FL, 33136, USA.
    Melasma is a common acquired pigmentary disorder marked by irregular hyperpigmented macules or patches and most commonly occurs in women of darker skin color. It is a chronic often-relapsing condition that causes negative psychosocial effects in those affected. Current treatments such as hydroquinone, kojic acid, and retinoids, among others, demonstrate variable efficacy and side-effect profiles. Read More

    Melasma: systematic review of the systemic treatments.
    Int J Dermatol 2017 Feb 27. Epub 2017 Feb 27.
    Division of Dermatology, University of Toronto, Toronto, Ontario, Canada.
    Currently available treatment options for melasma include prevention of UV radiation, topical lightening agents, chemical peels, and light-based and laser therapies. However, none have shown effective and sustained results, with incomplete clearance and frequent recurrences. There has been increasing interest recently in oral medications and dietary supplements in improving melasma. Read More

    A novel mutation in the STK11 gene causes heritable Peutz-Jeghers syndrome - a case report.
    BMC Med Genet 2017 Feb 23;18(1):19. Epub 2017 Feb 23.
    Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, No. 74 Zhongshan 2 Road, Guangzhou, 510080, China.
    Background: Peutz-Jeghers syndrome (PJS) is a rare disorder characterized by multiple gastrointestinal hamartomatous polyps and mucocutaneous pigmentation. STK11 has been identified as a causative gene for this disease.

    Case Presentation: Herein we report a Chinese Han kindred with PJS. Read More

    Soft palatal melanosis, a simple predictor for neoplasia in the upper aerodigestive tract in Japanese alcoholic men.
    Cancer Sci 2017 Feb 20. Epub 2017 Feb 20.
    Department of Health Promotion, National Institute of Public Health, Wako, Japan.
    Soft palatal melanosis can be detected by visual inspection during routine physical examination or even personally in a mirror. The aim of this study was to evaluate the association between squamous cell neoplasia in the upper aerodigestive tract (UAT) and soft palatal melanosis. We reviewed digitized records of high-quality endoscopic images of the soft palate of 1786 Japanese alcoholic men who underwent endoscopic screening. Read More

    Sun-protective behaviors in patients with cutaneous hyperpigmentation: A cross-sectional study.
    J Am Acad Dermatol 2017 May 16;76(5):841-846.e2. Epub 2017 Feb 16.
    Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts. Electronic address:
    Background: Disorders of hyperpigmentation are seen commonly in clinical practice. Despite numerous studies investigating sun-protective habits among healthy persons, little is known about these behaviors within patient populations with hyperpigmentation disorders.

    Objective: We sought to examine photo-protective behaviors and their associations in individuals with disorders of hyperpigmentation. Read More

    African ancestry is associated with facial melasma in women: a cross-sectional study.
    BMC Med Genet 2017 Feb 17;18(1):17. Epub 2017 Feb 17.
    Department of Dermatology, FMB-Unesp, Botucatu, SP, Brazil.
    Background: Melasma is a chronic acquired focal hypermelanosis affecting photoexposed areas, especially for women during fertile age. Several factors contribute to its development: sun exposure, sex steroids, medicines, and family history. Melanic pigmentation pathway discloses several SNPs in different populations. Read More

    [Primary malignant melanoma in the brain of a 7-month-old sheep (Ovis aries f. domestica)].
    Tierarztl Prax Ausg G Grosstiere Nutztiere 2017 Apr 15;45(2):108-111. Epub 2017 Feb 15.
    Dr. Dr. habil. Wolfram Breuer, Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit, Oberschleißheim, Veterinärstraße 2, 85764 Oberschleißheim, E-Mail:
    A case of malignant melanoma in a sheep's brain is described for the first time. In a 7-month-old sheep that had been euthanized due to ataxia, post-mortem and histopathologic examinations were performed. Both the brain and the calvarium were heavily infiltrated with neoplastic tissue. Read More

    Common Skin Conditions in Children: Neonatal Skin Lesions.
    FP Essent 2017 Feb;453:11-17
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

    Combined Jessner Solution and Trichloroacetic Acid Versus Trichloroacetic Acid Alone in the Treatment of Melasma in Dark-Skinned Patients.
    Dermatol Surg 2017 May;43(5):651-656
    *All authors are affiliated with the Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt.
    Background: Melasma is a common challenging pigmentary skin disorder especially in dark-skinned females urging them to seek medical help. Many modalities of treatment are available, but none is satisfactory.

    Objective: To compare safety and efficacy of combined trichloroacetic acid (TCA) (20%-25%) and Jessner's solution versus TCA (20%-25%) alone in dark patients with melasma. Read More

    Anti-melasma codrug of retinoic acid assists cutaneous absorption with attenuated skin irritation.
    Eur J Pharm Biopharm 2017 May 1;114:154-163. Epub 2017 Feb 1.
    Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan; Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan; Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Kweishan, Taoyuan, Taiwan. Electronic address:
    Melasma treatment with combined retinoic acid (RA) and hydroquinone (HQ) usually causes unsatisfactory outcomes and safety concerns. This study attempted to evaluate the cutaneous absorption and skin tolerance of the codrug conjugated with RA and HQ via ester linkage. The codrug's permeation of the pig skin was estimated using Franz diffusion cell. Read More

    Immunohistochemical profiling including beta-catenin in conjunctival melanocytic lesions.
    Exp Mol Pathol 2017 Apr 1;102(2):198-202. Epub 2017 Feb 1.
    Department of Pathology, Division of Neuropathology, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA, United States. Electronic address:
    Conjunctival melanocytic lesions encompass a group of clinically diverse, benign to malignant, neoplasms that may contain overlapping histopathological features, making definitive diagnosis challenging in some cases. In this series, we compared multiple immunohistochemical (IHC) markers in 11 conjunctival nevi, 10 primary acquired melanosis (PAM) lesions, and 11 conjunctival melanomas. Immunostains included the melanocytic markers HMB-45 and Melan-A, as well as the proliferative marker Ki-67. Read More

    Pulsed alexandrite laser for treatment of melasma in Asian patients.
    J Cosmet Laser Ther 2017 Feb 2:1-5. Epub 2017 Feb 2.
    a Department of Dermatology , Chang Gung Memorial Hospital and Chang Gung University College of Medicine , Taoyuan , Taiwan.
    Background: Melasma is a common acquired facial hypermelanosis with irregular brownish macules and patches. The clinical course is often fluctuated and refractory to treatment. The present study was conducted to evaluate the efficacy and safety of pulsed alexandrite laser for the treatment of melasma. Read More

    Clinical efficacy of liposome-encapsulated Aloe vera on melasma treatment during pregnancy.
    J Cosmet Laser Ther 2017 Jun 31;19(3):181-187. Epub 2017 Jan 31.
    b Department of Medical Biotechnology , School of Advance Science in Medicine, Tehran University of Medical Sciences , Tehran , Iran.
    Background: Melasma is a challenging dermatological condition during pregnancy. The aim of this study was to determine the clinical efficacy of a topical liposome-encapsulated Aloe vera preparation, on melasma in pregnant women. In order to enhance the bioavailability of Aloe vera leaf gel extract (AGE), liposomes encapsulating Aloe vera were prepared and examined for their biochemical properties. Read More

    Retrospective analysis of the treatment of melasma lesions exhibiting increased vascularity with the 595-nm pulsed dye laser combined with the 1927-nm fractional low-powered diode laser.
    Lasers Surg Med 2017 Jan 13;49(1):20-26. Epub 2016 Apr 13.
    Dermatology and Laser Surgery Center, 6400 Fannin St. Suite 2720, Houston, Texas.
    Background: Melasma presents a significant challenge to laser surgeons. Aggressive treatments often result in rebound melasma or post-inflammatory pigmentary alteration. Recent reports suggest melasma pathogenesis may have a vascular component. Read More

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