9,285 results match your criteria Melasma


Platelet-Rich Plasma, a powerful tool in dermatology.

J Tissue Eng Regen Med 2019 Feb 22. Epub 2019 Feb 22.

Cellular and Functional Biology and Biomolecules Engineering Group. School of Science, Antonio Nariño University, Bogotá, Colombia.

Platelet-rich plasma (PRP), a platelet concentrate contained in a small volume of plasma, has become a promising option in the last decade to treat different diseases related to the skin due to its high concentration of growth factors. When it is of autologous origin, it decreases the probability of suffering adverse reactions and transfusion-transmitted infections, thus it is an optimal and safe therapy for the patient. PRP has been used in the treatment of several dermatological conditions such as acne, alopecia and skin ulcers. Read More

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http://dx.doi.org/10.1002/term.2832DOI Listing
February 2019

Neurocutaneous Melanosis in Association With Large Congenital Melanocytic Nevi in Children: A Report of 2 Cases With Clinical, Radiological, and Pathogenetic Evaluation.

Front Neurol 2019 7;10:79. Epub 2019 Feb 7.

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.

Melanocytic nevi present at birth, or within the first few months of life, are defined as congenital melanocytic nevi (CMN). Neurocutaneous melanosis (NCM) is a rare disorder, represents pigment cell tumors of the leptomeninges, and occurs in association with large or multiple CMN. NCM carries an extremely poor prognosis. Read More

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http://dx.doi.org/10.3389/fneur.2019.00079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374324PMC
February 2019

Melanoma arising in a Giant congenital melanocytic nevus: two case reports.

Diagn Pathol 2019 Feb 19;14(1):21. Epub 2019 Feb 19.

Federal State Budgetary Institution, "N.N. Blokhin Medical Research Center of Oncology" of the Ministry of Health of the Russian Federation, 115478 Kashirskoye shosse, 24, Moscow, Russian Federation.

Background: A giant congenital melanocytic nevus (GCMN) is found in 0.1% of live-born infants. If present, the lesion has a chance of about 6% to develop into malignant melanoma. Read More

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http://dx.doi.org/10.1186/s13000-019-0797-1DOI Listing
February 2019

Melasma: How hormones can modulate skin pigmentation.

J Cosmet Dermatol 2019 Feb 18. Epub 2019 Feb 18.

San Gallicano Dermatological Institute (IRCCS), Rome, Italy.

We described-along with a genetic predisposition and exposure to sunlight, as the main factors for melasma development-pregnancy, hormonal therapies, and oral contraceptive pills. Whilst hormonal alteration or therapies are frequently reported in literature in association with melasma, studies analyzing the laboratoristic correlation are limited. We review data published on hormones variations both in women and males with melasma and report some peculiar clinical cases that further demonstrate how the relationship between hormone secretion and melasma development is difficult to be defined. Read More

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http://dx.doi.org/10.1111/jocd.12877DOI Listing
February 2019

Efficacy of microneedling with topical vitamin C in the treatment of melasma.

J Cosmet Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Faculty of Medicine, Department of Dermatology, Sohag University, Sohag University Hospital, Sohag, Egypt.

Background: Despite the wide therapeutic options available for the treatment of melasma, including many active topical medications, technologies with lights and peelings, clinical control of this disorder is extremely challenging.

Objectives: To evaluate the effect of microneedling with topical vitamin C in the treatment of melasma.

Methods: Thirty female patients with melasma received six sessions of microneedling with addition of topical vitamin C every two weeks. Read More

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http://dx.doi.org/10.1111/jocd.12878DOI Listing
February 2019
1 Read

Parry-Romberg syndrome treatment with fat transfer and a new bleaching formula.

J Cosmet Dermatol 2019 Feb 15. Epub 2019 Feb 15.

ISAPS, Athens, Greece.

Parry-Romberg syndrome is a hemifacial atrophy which can be complicated by melasma. We present two cases of Parry-Romberg syndrome, treated by fat transfer and bleaching of the skin using a modified "Kligman's formula." The atrophy, as well as the skin dyschromia, improved, and the results were stable. Read More

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http://dx.doi.org/10.1111/jocd.12819DOI Listing
February 2019

Ocular Surface Squamous Neoplasia Hiding in Primary Acquired Melanosis.

JAMA Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miami, Florida.

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http://archopht.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaophthalmol.2018.6503DOI Listing
February 2019
3 Reads

Gastric Tumoral Melanosis: a Rare Manifestation of Successfully Treated Malignant Melanoma.

Clin Gastroenterol Hepatol 2019 Feb 8. Epub 2019 Feb 8.

Department of General Medical Oncology, University Hospitals Leuven, KU Leuven, Belgium.

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http://dx.doi.org/10.1016/j.cgh.2019.02.006DOI Listing
February 2019
1 Read

Efficacy of mesotherapy with tranexamic acid and ascorbic acid with and without glutathione in treatment of melasma: A split face comparative trial.

J Cosmet Dermatol 2019 Feb 8. Epub 2019 Feb 8.

Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Introduction: Melasma is a prevalent annoying skin hyperpigmentation disorder that commonly involves reproductive-aged females. Variety of treatments with controversial results has been recommended. The aim of the current study was to evaluate combination therapy of tranexamic acid (TA) and vitamin C with and without glutathione with mesotherapy technique for treatment of melasma. Read More

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http://dx.doi.org/10.1111/jocd.12874DOI Listing
February 2019
1.000 Impact Factor

Analysis of the effect of different doses of oral tranexamic acid on melasma: a multicentre prospective study.

Eur J Dermatol 2019 Feb 8. Epub 2019 Feb 8.

Department of Dermatology, Kinki University Faculty of Medicine, Higashiosaka, Japan.

Background: Melasma is pale brown to dark brown hyperpigmentation of the facial skin that commonly affects women of reproductive age. Treatment methods for melasma include oral and topical use of vitamin C, hydroquinone ointment, and laser treatment, with unsatisfactory results. Tranexamic acid (TA) has been shown to be effective against melasma, however, the optimal dose has not been investigated. Read More

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http://dx.doi.org/10.1684/ejd.2018.3494DOI Listing
February 2019
1 Read

Laser and Laser Compound Therapy for Melasma: A Meta-Analysis.

J Dermatolog Treat 2019 Jan 31:1-19. Epub 2019 Jan 31.

b Clinical Research Center, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine , Guangzhou 510006 , China.

Background: Treatment of melasma is challenging because its pathogenesis is unclear and it is prone to recurrence. We performed a meta-analysis to evaluate the efficacy and safety of laser and laser compound therapy for melasma.

Methods: We searched the Cochrane, Embase, and Medline databases for all relevant studies published from inception to July 2018. Read More

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http://dx.doi.org/10.1080/09546634.2019.1577544DOI Listing
January 2019

Peutz-Jeghers Syndrome.

N Engl J Med 2019 Jan;380(5):472

R.G. Kar Medical College and Hospital, Kolkata, India

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http://dx.doi.org/10.1056/NEJMicm1806623DOI Listing
January 2019
1 Read

Black and Brown Oro-facial Mucocutaneous Neoplasms.

Authors:
Easwar Natarajan

Head Neck Pathol 2019 Jan 29. Epub 2019 Jan 29.

Section of Oral and Maxillofacial Pathology, University of Connecticut Health Center, 263 Farmington Ave, MC-0925, Farmington, CT, 06030, USA.

Black and brown-colored mucocutaneous lesions present a differential diagnostic challenge, with malignant melanoma being the primary clinical concern. The vast majority of pigmented lesions in the head and neck region are the result of benign, reactive factors such as post-inflammatory melanosis. However, it is not uncommon to discover a range of muco-cutaneous black and brown neoplasms in the oro-facial area. Read More

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http://dx.doi.org/10.1007/s12105-019-01008-2DOI Listing
January 2019
2 Reads

Black and Brown: Non-neoplastic Pigmentation of the Oral Mucosa.

Head Neck Pathol 2019 Jan 22. Epub 2019 Jan 22.

Louisiana State University, 1100 Florida Avenue, New Orleans, LA, 70119, USA.

Black and brown pigmentation of the oral mucosa can occur due to a multitude of non-neoplastic causes. Endogenous or exogenous pigments may be responsible for oral discoloration which can range from innocuous to life-threatening in nature. Physiologic, reactive, and idiopathic melanin production seen in smoker's melanosis, drug-related discolorations, melanotic macule, melanoacanthoma and systemic diseases are presented. Read More

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http://dx.doi.org/10.1007/s12105-018-0980-9DOI Listing
January 2019
3 Reads

An herbal H2 blocker in melasma treatment.

Curr Drug Discov Technol 2019 Jan 21. Epub 2019 Jan 21.

Health center, Mashhad University of Medical Sciences, Mashhad. Iran.

Background: Melasma is a skin pigmentation disorder that remains resistant to available therapies. The exact cause of melasma is unknown. Histamine is an inflammatory factor. Read More

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http://dx.doi.org/10.2174/1570163816666190121145653DOI Listing
January 2019
1 Read

Efficacy of Trifecting Night Cream, a Novel Triple acting Skin Brightening Product: A Double-blind, Placebo-controlled Clinical Study.

J Clin Aesthet Dermatol 2018 Dec 1;11(12):21-25. Epub 2018 Dec 1.

Drs. Jiang, Hino, and Stephens are with Thomas J. Stephens & Associates in Richardson, Texas.

Melasma is a common, persistent disorder of hyperpigmented facial skin predominantly attributed to ultraviolet light exposure, hormonal influences, and genetic predisposition. This double-blind, placebo-controlled, randomized clinical trial was conducted to assess the efficacy and tolerance of a multimodality night cream when used over a course of 24 weeks followed by a four-week regression in female subjects with moderate to severe melasma, presence of solar lentigines, and periocular lines and wrinkles. Subjects were randomized into one of two groups: Cell 1 received Trifecting Night Cream (Envy Medical, Long Beach, California) 1. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334832PMC
December 2018

Common Neonatal Rashes.

Pediatr Ann 2019 Jan;48(1):e16-e22

Skin eruptions are commonly encountered in the neonatal and infant period and can be a source of concern for providers and parents alike. We present a brief, clinically focused discussion on topics commonly encountered by the pediatrician with a focus on pearls of knowledge to help distinguish diseases from one another and from more serious conditions. We review miliaria, transient neonatal pustular melanosis, neonatal cephalic pustulosis, erythema toxicum neonatorum, diaper dermatitis, seborrheic dermatitis, and atopic dermatitis. Read More

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http://dx.doi.org/10.3928/19382359-20181206-01DOI Listing
January 2019
4 Reads

[Diagnosis and treatment for 46 cases of Peutz-Jeghers syndrome].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Dec;43(12):1323-1327

Department of Gastroenterology, the Seventh Medical Center of PLA General Hospital, Beijing 100700, China.

Objective: To explore the clinical features, pathological features, gene test results, diagnosis, treatment and prognosis of Peutz-Jeghers syndrome(PJS).
 Methods: We retrospectively analyzed clinical data of 46 hospitalized cases of PJS during 2007 and 2017.
 Results: All 46 patients had mucocutaneous melanin pigmentation and multiple gastrointestinal polyposis. Read More

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http://www.csumed.org/xbwk/CN/10.11817/j.issn.1672-7347.2018
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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.12.007DOI Listing
December 2018
4 Reads

Azelaic acid-loaded nanoemulsion with hyaluronic acid - a new strategy to treat hyperpigmentary skin disorders.

Drug Dev Ind Pharm 2019 Jan 15:1-9. Epub 2019 Jan 15.

a Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul (UFRGS) , Porto Alegre , Brazil.

Objective: To develop an azelaic acid (AzA)-loaded nanoemulsion with hyaluronic acid (HA) as a double targeting strategy to increase drug retention and tyrosinase inhibition activity.

Significance: Dermic melasma is a recalcitrant disease. Therefore, the development of new technologies that allow a deeper penetration in the skin while enhancing the efficacy of a safe and well-known dermatological active, like AzA, is a very promising alternative to improve the treatment of this disease. Read More

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https://www.tandfonline.com/doi/full/10.1080/03639045.2019.1
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http://dx.doi.org/10.1080/03639045.2019.1569032DOI Listing
January 2019
4 Reads

Melanosis Coli: A Case of Mistaken Identity-A Case Report.

Perm J 2019 ;23

Division of Acute Care Surgery and Trauma, Memorial Regional Hospital, Hollywood, FL.

Introduction: Melanosis coli is a condition in which the colon develops a brown to black discoloration. It is associated with chronic laxative use and frequently diagnosed incidentally during colonoscopy or histopathologic evaluation.

Case Presentation: A 74-year-old woman presented to the Emergency Department with severe abdominal pain and bilious emesis. Read More

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http://dx.doi.org/10.7812/TPP/18-063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326559PMC
January 2019
1 Read

Clinical efficacy of laser combined with menstrual regulation in the treatment of female melasma: a retrospective study.

Lasers Med Sci 2019 Jan 8. Epub 2019 Jan 8.

Department of Plastic Surgery, Jiangsu Province Hospital of TCM, Affiliated Hospital of Nanjing University of TCM, No. 155, Hanzhong Road, Nanjing, 210029, China.

The aim of this study was to evaluate the clinical efficacy of using a Medlite C6 Q-switch Nd:YAG laser combined with menstrual regulation-based traditional Chinese medicine (TCM) in the treatment of female melasma. Forty cases of female patients with melasma, who were treated between December 2013 and December 2015 at the Jiangsu Provincial Hospital of Traditional Chinese Medicine, were reviewed retrospectively. Twenty patients received Q-switch Nd:YAG 1064 nm laser treatments combined with menstrual regulation treatments (experimental group), and 20 patients were treated only with the laser (control group). Read More

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http://link.springer.com/10.1007/s10103-018-02698-w
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http://dx.doi.org/10.1007/s10103-018-02698-wDOI Listing
January 2019
4 Reads

Photo-Modification of Melanin by a Mid-infrared Free-electron Laser.

Photochem Photobiol 2019 Jan 5. Epub 2019 Jan 5.

Institute of Advanced Energy, Kyoto University, Gokasho, Uji, Kyoto, Japan.

Melanin is rigidly constructed by several nitrogen-containing aromatic rings, and its excess accumulation in skin tissue is closely associated with melanosis. Although visible lasers (wavelength: 600-1000 nm) are conventionally used for the photo-thermolysis of melanocyte, several pigmented nevi are difficult to be treated. Here, we propose an alternate method for targeting the molecular structure of melanin using an infrared free-electron laser (FEL) tuned to 5. Read More

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http://dx.doi.org/10.1111/php.13079DOI Listing
January 2019
1 Read

Comparison of the Inflammatory Infiltrates in Tumoral Melanosis, Regressing Nevi, and Regressing Melanoma.

Am J Dermatopathol 2018 Dec 19. Epub 2018 Dec 19.

Department of Dermatology, University of Florida College of Medicine, Gainesville, FL.

Background: Tumoral melanosis (TM) is a histologic diagnosis characterized by abundant pigment-laden macrophages in the dermis. It is generally thought to represent a regressed melanoma, although it has also been reported after benign pigmented lesions as well. Determining the antecedent lesion in cases of TM is of clinical importance to accurately guide therapy and prognostication. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001346DOI Listing
December 2018
4 Reads

Pseudomelanosis intestini "from pylorus to jejunum:" A rare endoscopic finding in a patient with GI bleeding.

J Family Med Prim Care 2018 Sep-Oct;7(5):1120-1122

Department of Gastroenterology, Providence-Providence Park Hospital, Michigan State University College of Human Medicine, Southfield, Michigan, USA.

Pseudomelanosis of the gastrointestinal (GI) tract is a rare condition used to describe the accumulation of pigment deposits in the intestinal mucosa. Its underlying cause is not well understood. It has been described in association with gastrointestinal hemorrhage, chronic kidney disease, hypertension, diabetes mellitus, and medications such as hydralazine, ferrous sulfate, and furosemide. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_53_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259497PMC
January 2019

Evaluation of Using Fractional CO Laser plus NB-UVB versus NB-UVB Alone in Inducing Marginal Repigmentation of Vitiligo Lesions.

J Dermatolog Treat 2018 Dec 28:1-13. Epub 2018 Dec 28.

a Skin Research Center, Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Background: Vitiligo is a common depigmenting skin disorder, characterized by patchy loss of skin color and finding effective treatment has remained a challenging issue.

Methods: A paired (half-body) randomized clinical trial study was done to compare the efficacy and the safety of narrowband ultraviolet B (NB-UVB) plus fractional CO versus NB-UVB alone in stimulation of marginal repigmentation of vitiliginous patches. One side of the body was randomly treated with a fractional CO laser and NB-UVB twice weekly, while the other side was exposed only to NB-UVB with the same manner. Read More

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http://dx.doi.org/10.1080/09546634.2018.1564232DOI Listing
December 2018

Brightening and Improvement of Facial Skin Quality in Healthy Female Subjects With Moderate Hyperpigmentation or Dark Spots and Moderate Facial Aging

J Drugs Dermatol 2018 Dec;17(12):1310-1315

Objective: To evaluate the safety and efficacy of ISDINCEUTICS Melaclear® serum (Barcelona, Spain) on skin brightness, skin quality, and signs of facial aging. Design: This was a single-center, observational, open label, prospective clinical study. Ten healthy females (ages 30-70) with moderate signs of facial aging and moderate photodamage (hyperpigmentation and/or sun spots) were enrolled. Read More

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December 2018
14 Reads

[What's new in dermatological treatment?]

Authors:
V Descamps

Ann Dermatol Venereol 2018 Dec;145 Suppl 7:VIIS47-VIIS55

Service de dermatologie, Hôpital Bichat, université Paris 7, Paris, France. Electronic address:

The therapeutic revolution in the management of inflammatory dermatoses is under way. The therapeutic arsenal is expanding in the field of psoriasis, including biologics (TNF blockers, anti-IL12/IL23, anti-IL17, and anti-IL23 antibodies), new small molecules (tyrosine kinase inhibitor), and a new biologic for generalized pustular psoriasis (anti-IL36 receptor). New biologics will be soon available in the field of atopic dermatitis in addition to anti-IL4/IL13 antibodies. Read More

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http://dx.doi.org/10.1016/S0151-9638(18)31289-4DOI Listing
December 2018
8 Reads

[What's new in interventional dermatology?]

Authors:
C Raimbault

Ann Dermatol Venereol 2018 Dec;145 Suppl 7:VIIS11-VIIS16

Dermatologue libérale, 30, rue des Clercs, 57000 Metz, France, présidente du Groupe de dermatologie esthétique et correctrice (gDEC) de la Société française de dermatologie, past présidente de l'Association de dermatologie esthétique et laser de l'Est (ADELE). Electronic address:

This year, many publications have focused on understanding, avoiding and treating vascular complications when injecting fillers. New protocols for the use of hyaluronidase have shown their effectiveness in preventing skin necrosis or blindness after vascular embolism when injecting hyaluronic acid. Other areas of interventional dermatology have been well documented: myomodulation is an interesting concept that describes the impact of the injection depth of a filler on muscle forces in order to correct the balances between the lowering and elevators during congenital or acquired defcits with aging. Read More

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http://dx.doi.org/10.1016/S0151-9638(18)31284-5DOI Listing
December 2018
1 Read

Senescent fibroblasts in melasma pathophysiology.

Exp Dermatol 2018 Oct 29. Epub 2018 Oct 29.

Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.

It has been proposed that melasma is a photoageing skin disorder. The photoaged fibroblasts have been suggested as an important source of melanogenic factors which are involved in the regulation of pigmentation. To investigate whether melasma includes senescent cells, lesional and perilesional normal skin from 38 melasma patients was assessed using a cell senescence marker, p16 . Read More

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http://dx.doi.org/10.1111/exd.13814DOI Listing
October 2018
8 Reads

[Friction melanosis and mode of dress].

Pan Afr Med J 2018 17;30:215. Epub 2018 Jul 17.

Service de Dermatologie-Vénérologie, Hôpital d'Instruction Mohammed V, Rabat, Maroc.

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http://www.panafrican-med-journal.com/content/article/30/215
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http://dx.doi.org/10.11604/pamj.2018.30.215.16239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294982PMC
January 2019
1 Read

Melanosis Coli: A Helpful Contrast Effect or a Harmful Pigmentation?

Clin Med Insights Gastroenterol 2018 4;11:1179552218817321. Epub 2018 Dec 4.

Department of Gastroenterology and Hepatology, Hillel Yaffe Medical Center, Technion Faculty of Medicine, Hadera, Israel.

Background: Melanosis coli, a brown discoloration of colonic mucosa, is considered as a benign condition mainly observed in patients under chronic anthranoid laxatives. Recent data link this condition with an increased adenoma detection rate. Moreover, its tumorigenic potential and possible association with the development of colorectal cancer remains uncertain. Read More

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http://dx.doi.org/10.1177/1179552218817321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299301PMC
December 2018
6 Reads

Corneal dysplastic melanosis associated with recurrent corneal erosions: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13367

Department of Ophthalmology, Seoul National University College of Medicine.

Rationale: Pigmented lesions of conjunctiva and cornea can be observed in various conditions, from the benign nevus to malignant melanoma. Pigmented acquired melanosis (PAM) is one of them, which is a neoplastic proliferation with malignant transformation potential of melanocytes. However, to our knowledge, there has been no report as to a disturbance of corneal barrier function caused by PAM. Read More

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http://dx.doi.org/10.1097/MD.0000000000013367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319972PMC
December 2018
8 Reads

Quality of life in a cohort of melasma patients in Australia.

Australas J Dermatol 2018 Dec 18. Epub 2018 Dec 18.

CHROMA Dermatology, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/ajd.12969DOI Listing
December 2018
1 Read

Identification of candidate biomarkers associated with apoptosis in melanosis coli: GNG5, LPAR3, MAPK8, and PSMC6.

Biosci Rep 2019 Jan 18;39(1). Epub 2019 Jan 18.

Clinical Laboratory, Hangzhou Cancer Hospital, Hangzhou 310000, Zhejiang, China

Melanosis coli (MC) is a disorder of pigmentation of the wall of the colon, often identified at the time of colonoscopy. The aim of the present study is to identify candidate biomarkers for MC. The transcriptome data for MC (GSE78933) with five MC tissues and five corresponding normal tissues is obtained from the NCBI Gene Expression Omnibus (GEO) database. Read More

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http://dx.doi.org/10.1042/BSR20181369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340944PMC
January 2019

A case of ochronosis successfully treated with the picosecond laser.

J Cosmet Dermatol 2018 Dec 16. Epub 2018 Dec 16.

Clínica Dermatológica Isela Méndez, Ciudad de México, México.

Exogenous ochronosis is a cutaneous condition characterized by blue-black pigmentation resulting as a complication of long-term application of skin-lightening creams containing hydroquinone and other substances such as quinine, phenol and mercury derivatives. We report a case of a 55-year-old woman who developed exogenous ochronosis as a result of prolonged use of topical hydroquinone for 5 years, characterized by greyish hyperpigmented patches on the nose and cheeks. The diagnosis was confirmed histologically. Read More

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http://dx.doi.org/10.1111/jocd.12834DOI Listing
December 2018
10 Reads

Evaluation of the Novel Synthetic Tyrosinase Inhibitor ()-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498) and .

Molecules 2018 Dec 13;23(12). Epub 2018 Dec 13.

College of Pharmacy, Pusan National University, Busan 46241, Korea.

Tyrosinase is a key enzyme in melanin synthesis, catalyzing the initial rate-limiting steps of melanin synthesis. Abnormal and excessive melanin synthesis is the primary cause of serious skin disorders including melasma, senile lentigo, freckles, and age spots. In attempts to find potent and safe tyrosinase inhibitors, we designed and synthesized a novel compound, ()-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498), and evaluated its tyrosinase inhibitory activity and . Read More

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http://dx.doi.org/10.3390/molecules23123307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321646PMC
December 2018
2 Reads

Effects of moringa leaves () extraction on quality changes and melanosis of giant freshwater prawn () during chilled storage.

Ital J Food Saf 2018 Sep 26;7(3):6846. Epub 2018 Sep 26.

Institute of Tropical Aquaculture.

An aqueous extraction of moringa () leaves were prepared as the edible coats for keeping the quality of the giant freshwater prawn (). In addition, the antioxidant properties and activity; total phenolic content (TPC), total flavonoid contents (TFC), free radical scavenging activity (DPPH), and ferric reducing antioxidant power (FRAP) of moringa leaves were also determined. The phenolic compounds and antioxidant properties in the moringa leaves are low; 16. Read More

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http://dx.doi.org/10.4081/ijfs.2018.6846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240840PMC
September 2018
1 Read

Significant therapeutic response to cysteamine cream in a melasma patient resistant to Kligman's formula.

J Cosmet Dermatol 2019 Feb 11;18(1):293-295. Epub 2018 Dec 11.

Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.

L-Cysteamine is a biological antioxidant produced during the coenzyme A metabolism cycle and is naturally present in all mammalian cells. The efficacy of topical cysteamine for the treatment of melasma has been recently shown in two double-blind, randomized, and placebo-controlled clinical trials. Herein, we report a 44-year-old patient with melasma resistant to Kligman's formula (Pigmanorm cream), who was successfully treated with topical cysteamine as a new depigmenting agent. Read More

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http://dx.doi.org/10.1111/jocd.12837DOI Listing
February 2019
4 Reads

Evaluation of oral tranexamic acid in the treatment of melasma.

J Cosmet Dermatol 2018 Dec 9. Epub 2018 Dec 9.

Universidade de Mogi das Cruzes, Dermatology, Mogi das Cruzes, Brazil.

Background: Melasma is an acquired, chronic, recurrent hypermelanosis that occurs exclusively in areas exposed to the sun. Its treatment can be very challenging. Tranexamic acid (TA) is an inhibitor of plasmin, and it is a synthetic derivative of the amino acid lysine that reversibly blocks binding sites on the plasminogen molecule, inhibiting the plasminogen activator from converting plasminogen to plasmin. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12830
Publisher Site
http://dx.doi.org/10.1111/jocd.12830DOI Listing
December 2018
13 Reads

Tranexamic Acid for Adults with Melasma: A Systematic Review and Meta-Analysis.

Biomed Res Int 2018 6;2018:1683414. Epub 2018 Nov 6.

Department of Plastic Surgery, Zhejiang Hospital, Hangzhou 310013, China.

Objective: Melasma is a highly prevalent, chronic, and pigmentary disorder. This systematic review aims to evaluate the efficacy and safety of tranexamic acid (TA) for the treatment of adults with melasma.

Methods: We independently searched 3 databases from beginning to 26 April, 2018. Read More

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http://dx.doi.org/10.1155/2018/1683414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247725PMC
November 2018
2 Reads

Acquired diffuse slate-grey facial dyspigmentation due to henna: an unrecognized cause of pigment contact dermatitis in Korean patients.

Eur J Dermatol 2018 Oct;28(5):644-648

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Henna is a vegetable hair dye that can be used by individuals who are sensitized to oxidative dyes due to low allergenicity. The reported incidence of slate-grey facial dyspigmentation following the use of henna hair dye is extremely rare. This study aimed to identify the clinical, dermoscopic, and histopathological features of slate-grey facial dyspigmentation following the use of henna hair dye in Korean patients. Read More

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http://dx.doi.org/10.1684/ejd.2018.3404DOI Listing
October 2018
15 Reads

In vivo multiphoton microscopy of melasma.

Pigment Cell Melanoma Res 2018 Dec 1. Epub 2018 Dec 1.

Unilever R&D, Trumbull, Connecticut.

Melasma is a skin disorder characterized by hyperpigmented patches due to increased melanin production and deposition. In this pilot study, we evaluate the potential of multiphoton microscopy (MPM) to characterize non-invasively the melanin content, location, and distribution in melasma and assess the elastosis severity. We employed a clinical MPM tomograph to image in vivo morphological features in melasma lesions and adjacent normal skin in 12 patients. Read More

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http://doi.wiley.com/10.1111/pcmr.12756
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http://dx.doi.org/10.1111/pcmr.12756DOI Listing
December 2018
6 Reads

Histopathological comparison of lesional and perilesional skin in melasma: A cross-sectional analysis.

Indian J Dermatol Venereol Leprol 2018 Dec 5. Epub 2018 Dec 5.

Consultant Dermatologist and Epidemiologist, Mumbai, Maharashtra, India.

Background: Melasma is a common acquired hyperpigmentary disorder of the sun exposed skin, especially the face. The pathogenesis is unclear but interplay between genetic factors, hormones and ultraviolet radiation is important. We have evaluated the histological characteristics of melasma and compared the findings with adjacent normal skin. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_866_17DOI Listing
December 2018
3 Reads

Bilateral Iris Mammillations in Amblyopic Eyes without Oculodermal Melanocytosis or Neurofibromatosis.

Case Rep Ophthalmol Med 2018 29;2018:2534042. Epub 2018 Oct 29.

Department of Ophthalmology, Teikyo University School of Medicine, Tokyo 173-8605, Japan.

Purpose: Iris mammillations are related to oculodermal melanosis and iris nevi. We report a rare case of bilateral simple iris mammillations without ocular melanosis or systemic neuronal disorders.

Case Report: A healthy 10-year-old Japanese girl was found incidentally to have bilateral iris mammillations while being treated for amblyopia. Read More

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http://dx.doi.org/10.1155/2018/2534042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231380PMC
October 2018
2 Reads

Assessing skin disease and associated health-related quality of life in a rural Lao community.

BMC Dermatol 2018 Dec 4;18(1):11. Epub 2018 Dec 4.

Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology laboratory, Mahosot Hospital, Vientiane, Laos.

Background: Skin diseases are common and often have an impact on an individual's health-related quality of life. In rural communities where access to healthcare may be limited and individuals rely on farming for food and income, the impact of skin diseases may be greater. The objectives for this study were to perform an assessment of skin disease prevalence in a rural village in Laos and assess the associated impact of any skin disease found using the Dermatology Life Quality Index (DLQI). Read More

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http://dx.doi.org/10.1186/s12895-018-0079-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278038PMC
December 2018
14 Reads

Melasma Associated with Periodontitis, Anemia, and Vitamin D Abnormalities: A Chance Occurrence or a Syndrome.

J Contemp Dent Pract 2018 Oct 1;19(10):1254-1259. Epub 2018 Oct 1.

Department of Oral Medicine and Radiology, Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre Hyderabad, Telangana, India.

Aim: To correlate the possible association between melasma, periodontitis, vitamin D abnormalities, and anemia.

Materials And Methods: A total of 192 subjects, of either gender within the age group of 30 to 70 years were divided equally into two groups, group I (case group, patients with melasma) and group II (control group, patients without melasma). In all the subjects, anemia and periodontitis were checked clinically, along with biochemical evaluation of serum vitamin D levels and hemoglobin (Hb) percentage. Read More

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October 2018
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Oral tranexamic acid for the treatment of melasma.

Authors:
F R Ali

Clin Exp Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Dermatological Surgery and Laser Unit, Guy's Cancer Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1111/ced.13831DOI Listing
November 2018
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Clinicopathologically problematic melanocytic tumors: a case-based review.

Dermatol Pract Concept 2018 Oct 31;8(4):306-313. Epub 2018 Oct 31.

Anatomic Pathology Unit, Hospital of Macerata, Italy.

Background: In spite of recent advances in the histopathological and molecular diagnosis of melanocytic neoplasms, a certain proportion of these lesions remain a daunting challenge for both the clinician and the pathologist.

Objectives: To emphasize the importance of close collaboration between clinicians and pathologists in case of problematic melanocytic lesions.

Patients: We report and discuss 5 problematic scenarios of melanocytic lesions, including tumoral melanosis, nevoid melanoma, lentiginous melanoma, spitzoid melanoma and BAPoma that may pose diagnostic difficulties in our practice. Read More

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http://dx.doi.org/10.5826/dpc.0804a12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246059PMC
October 2018
1 Read