Spontaneous Regression of Diffuse Periosteal Melanotic Neuroectodermal Tumor of Infancy in the Tibia, With 13-Year Follow-up.
J Pediatr Hematol Oncol 2018 Apr 4. Epub 2018 Apr 4.
Departments of Pathology, Radiology, and Pediatric Hematology-Oncology, Loma Linda University Health, Loma Linda, CA.
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare entity primarily affecting the craniofacial bones during the first year of life, with only 5 reported cases involving peripheral long bones. We herein present a case of MNTI in the tibia of an infant, with a somewhat atypical presentation, and a noteworthy clinical course characterized by progressive spontaneous resolution without therapy, thus sparing the child the trauma of amputation. There is no evidence of active residual or recurrent disease with 13-year follow-up. Read More