414 results match your criteria Melanotic Neuroectodermal Tumor of Infancy


Mandibular Melanotic Neuroectodermal Tumor of Infancy: Interdisciplinary Treatment from 2 Months to 19 Years of Age.

J Maxillofac Oral Surg 2022 Mar 21;21(1):105-111. Epub 2021 Apr 21.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Melanotic neuroectodermal tumor of infancy (MNTI) is a clinically distinctive, benign neoplasm of neural crest origin. The tumor develops usually in the anterior maxilla and rarely in the skull and mandible. This is a report of the interdisciplinary treatment of a rare case of MNTI occurring in the mandible. Read More

View Article and Full-Text PDF

Melanotic neuroectodermal tumor of infancy in the mandible: A case report.

Medicine (Baltimore) 2021 Dec;100(50):e28001

Division of Reconstructive Surgery for Oral and Maxillofacial Region, Faculty of Dentistry & Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan.

Rationale: Melanocytic neuroectodermal tumor of infancy (MNTI) is a rare benign pigmented neoplasm that arises from the neural crest and has an aggressive growth pattern. It is predominantly seen in infants under 1 year of age, and the most common site of involvement is the maxilla. The currently accepted treatment is removal by surgical resection. Read More

View Article and Full-Text PDF
December 2021

Melanotic neuroectodermal tumor of infancy of maxilla: Report of a case with review of literature.

J Oral Maxillofac Pathol 2021 May-Aug;25(2):351-355. Epub 2021 Aug 31.

Department of Oral & Maxillofacial Surgery, Vydehi Institute of Dental, Sciences, Bangalore, Karnataka, India.

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, fast-growing, pigmented neoplasm of neural crest origin. Despite of its rapid and locally infiltrative growth, it is still considered benign with high recurrence rate and malignant potential, so early diagnosis is extremely important to limit its local expansion. Recurrences can be expected primarily because of incomplete excision, tumor dissemination, or due to its multicentric nature. Read More

View Article and Full-Text PDF

Melanotic Neuroectodermal Tumor of Infancy: Does Enucleation Alone Suffice?

J Indian Assoc Pediatr Surg 2021 Jul-Aug;26(4):265-267. Epub 2021 Jul 12.

Department of Pediatric Surgery, Narayana Health, Bengaluru, Karnataka, India.

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare melanin-containing mesenchymal tumor of neural crest origin. We present a case of MNTI in a 1-year-old girl. It was managed successfully with conservative excision (enucleation). Read More

View Article and Full-Text PDF

The Role of Chemotherapy in Management of Inoperable, Metastatic and/or Recurrent Melanotic Neuroectodermal Tumor of Infancy-Own Experience and Systematic Review.

Cancers (Basel) 2021 Jul 31;13(15). Epub 2021 Jul 31.

Department of Pediatrics, Hematology and Oncology, Medical University of Gdansk, 80-210 Gdansk, Poland.

Melanotic Neuroectodermal Tumor of Infancy (MNTI) is a very rare pediatric neoplasm of neural crest origin. In most cases, it develops in infants as a localized tumor of the maxilla, and surgery is usually curative. In less than 10% of patients with inoperable, metastatic or persistently recurring MNTI, chemotherapy (CHT) may be considered; however, its role is still unclear. Read More

View Article and Full-Text PDF

Melanotic Neuroectodermal Tumor of Infancy: A Clinicopathological and V600E Mutation Study of 11 Cases.

Front Oncol 2021 20;11:668505. Epub 2021 May 20.

Department of Oral Pathology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai, China.

Purpose: To investigate the clinicopathological features and V600E mutation of melanotic neuroectodermal tumor of infancy (MNTI).

Materials And Methods: Eleven cases of MNTI diagnosed at the Department of Oral Pathology were collected. Clinicopathological characteristics were obtained from the medical records. Read More

View Article and Full-Text PDF

Pineal anlage tumor: A case report and clinico-pathological review.

Clin Neurol Neurosurg 2021 Jul 5;206:106629. Epub 2021 May 5.

Department of Radiotherapy and Oncology, PGIMER, Chandigarh.

Pineal anlage tumor (PAT) is an extremely rare tumor of paediatric population. It is considered as a subtype of pineoblastoma having ectomesenchymal/ rhabdomyoblastic and cartilaginous differentiation. PAT is presumed to have an aggressive behaviour with propensity for craniospinal fluid (CSF) spread due to histologically resemblance with pineoblastoma, thus requiring intensive multimodality treatment with craniospinal irradiation and chemotherapy. Read More

View Article and Full-Text PDF

[Orbital melanotic neuroectodermal tumor in an infant].

Authors:
Y X Wu M Y Ren

Zhonghua Yan Ke Za Zhi 2021 May;57(5):372-374

Department of Orbital Disease and Ocular Tumor, Hebei Eye Hospital, Xingtai 054001, China.

A 3-month-old infant patient presented with a 1-week history of a quickly progressive mass in the left eye. A hard, irregularly shaped tumor was found in the superolateral orbit. B-scan showed an uneven hypoecho and an undefined lesion. Read More

View Article and Full-Text PDF

Melanotic Neuroectodermal Tumor of Infancy at Skull: Rare and Rapid-Growing Tumor but Histologically Benign.

Pediatr Neurosurg 2021 16;56(3):306-311. Epub 2021 Apr 16.

Division of Pediatric Neurosurgery, Department of Surgery, Queen Sirikit National Institute of Child Heath, Bangkok, Thailand.

Introduction: Melanotic neuroectodermal tumor of infancy (MNTI) is a rare and rapid-growing tumor. However, a neurosurgeon should not overlook this entity when differential diagnosing rapid-growing skull tumor because its histology nature is just benign, and the prognosis is much better than other malignant tumors.

Case Presentation: We reported the case of a 5-month old male presenting with progressive rapid-growing skull tumor which became 10 cm in diameter in only 5 months compared to the normal head circumference at birth. Read More

View Article and Full-Text PDF
October 2021

Melanotic Neuroectodermal Tumor of Infancy in the Epididymis: A Rare and Considerable Cause of Scrotal Mass.

Urology 2021 Oct 14;156:e141-e143. Epub 2021 Apr 14.

Department of Pathology, Beijing Children's Hospital, National Center for Children's Health, Beijing, China.

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, benign neoplasm with a predilection for children that predominantly involves the craniofacial region. Here we report 2 cases of MNTI involving epididymis, placing emphasis on the sonographic features. Both appeared to be hypoechoic, regular shaped masses with abundant blood supplies. Read More

View Article and Full-Text PDF
October 2021

Odontogenic and Developmental Oral Lesions in Pediatric Patients.

Head Neck Pathol 2021 Mar 15;15(1):71-84. Epub 2021 Mar 15.

Academic Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK.

This article reviews odontogenic and developmental oral lesions encountered in the gnathic region of pediatric patients. The process of odontogenesis is discussed as it is essential to understanding the pathogenesis of odontogenic tumors. The clinical presentation, microscopic features, and prognosis are addressed for odontogenic lesions in the neonate (dental lamina cysts/gingival cysts of the newborn, congenital (granular cell) epulis of the newborn, melanotic neuroectodermal tumor, choristoma/heterotopia, cysts of foregut origin), lesions associated with unerupted/erupting teeth (hyperplastic dental follicle, eruption cyst, dentigerous cyst, odontogenic keratocyst/keratocystic odonogenic tumor, buccal bifurcation cyst/inflammatory collateral cyst) and pediatric odontogenic hamartomas and tumors (odontoma, ameloblastic fibroma, ameloblastoma, adenomatoid odontogenic tumor, primordial odontogenic tumor). Read More

View Article and Full-Text PDF

Melanotic Neuroectodermal Tumor of Infancy in the Ulna of an Infant: A Very Rare Tumor: A Case Report.

JBJS Case Connect 2021 03 8;11(1). Epub 2021 Mar 8.

Department of Orthopaedics, Aster Medcity, Kochi, Kerala, India.

Case: A 4-month-old boy presented with a nontender swelling of the right proximal forearm of 2 months' duration. Radiological evaluation showed lytic lesion surrounded by sclerotic bone in the ulna with soft-tissue extension. Histopathological examination showed tumor of round and epithelioid cells containing melanin, interpreted as melanotic neuroectodermal tumor. Read More

View Article and Full-Text PDF

Melanotic Neuroectodermal Tumor of Infancy (MNTI) and Pineal Anlage Tumor (PAT) Harbor A Medulloblastoma Signature by DNA Methylation Profiling.

Cancers (Basel) 2021 Feb 9;13(4). Epub 2021 Feb 9.

Department of Pediatric Onco-Hematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.

MNTI is a rare tumor of indeterminate histogenesis and molecular signature. We performed methylation and copy number variation (CNV) profiles in patients with MNTI ( = 7) and PAT ( = 1) compared to the methylation brain tumor classifier v11b4 (BT-C) and the medulloblastoma (MB) classifier group 3/4 v1.0 (MB3/4-C). Read More

View Article and Full-Text PDF
February 2021

[Melanotic neuroectodermal tumor of infancy: a clinicopathological study of three cases].

Zhonghua Bing Li Xue Za Zhi 2021 Feb;50(2):131-133

Department of Pathology,the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

View Article and Full-Text PDF
February 2021

Melanotic neuroectodermal tumor of infancy successfully treated with metformin: A case report.

Medicine (Baltimore) 2020 Nov;99(45):e22303

Department of Surgery, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Rationale: Melanotic neuroectodermal tumor of infancy (MNTI) is a rare tumor originated from neural crest cells with the potential for recurrence and metastasis. The peak age for the disease is during the first year after birth. The current therapy is primarily surgery. Read More

View Article and Full-Text PDF
November 2020

Vascularized Composite Parietal Bone Flap for Immediate Reconstruction of a Hemi-Maxillectomy Defect in an Infant.

J Craniofac Surg 2020 Nov/Dec;31(8):2334-2338

Division of Plastic and Reconstructive Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT.

Background: Surgical resection of maxillary tumors can result in defects that can be difficult to reconstruct by conventional means due to the complex functional and anatomic nature of the midface and lack of regional bone flap options in the head and neck. Many reconstructive methods have been used to repair maxillary defects, but the ideal technique for the reconstruction of hemi-maxillectomy defects in growing pediatric patients has yet to be determined.

Methods: The authors present a rare pediatric patient with melanotic neuroectodermal tumor of infancy resulting in a hemi-maxillectomy defect after resection that was reconstructed using a pedicled vascularized composite flap consisting of temporalis muscle, pericranium, and parietal bone. Read More

View Article and Full-Text PDF

Melanotic Neuroectodermal Tumor of Infancy: A Rare Case Report.

Contemp Clin Dent 2020 Apr-Jun;11(2):168-170. Epub 2020 Aug 7.

Department of Oral Medicine and Radiology, Dr. D. Y. Patil Dental School, Pune, Maharashtra, India.

A rare case melanotic neuroectodermal tumor of infancy occurring in 2-year-old girl affecting left maxilla is described. Computed tomography showed benign expansile type of lesion affecting left maxilla. The lesion was surgically excised completely. Read More

View Article and Full-Text PDF

Oral melanotic neuroectodermal tumor of infancy: Management of a case affecting the maxilla.

J Indian Soc Pedod Prev Dent 2020 Jul-Sep;38(3):319-322

Department of Oral and Maxillofacial Surgery, Government College of Dentistry, Indore, Madhya Pradesh, India.

Melanotic neuroectodermal tumor is a rare benign congenital neoplasm involving the head-and-neck region found in infants <1 year of age. The lesion most commonly affects the maxilla. We report the case of a 4-month-old male child with a tumor involving the anterior region of the maxilla along with a brief review of literature, differential diagnosis, and treatment. Read More

View Article and Full-Text PDF
October 2020

Pigmented Lesions.

Dermatol Clin 2020 Oct;38(4):485-494

Department of Oral Surgery, University of Pennsylvania, School of Dental Medicine, 240 South 40th Street, Philadelphia, PA 19104, USA.

Oral pigmented lesions have a wide range of clinical presentations, some of which correlate with cutaneous pigmented lesions. This article highlights these correlates and underscores important differences that can potentially have clinical impact. Moreover, given a nonspecific presentation of an oral pigmented lesion, the article provides a reference to aid clinicians with differential diagnoses based on clinical features. Read More

View Article and Full-Text PDF
October 2020

Calvarial Melanotic Neuroectodermal Tumor of Infancy with Rhabdomyosarcomatous differentiation-A Rare Case.

World Neurosurg 2021 01 4;145:134-141. Epub 2020 Sep 4.

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Background: Malignant neuroectodermal tumor of infancy is a rare neural crest cell-derived neoplasm of infants. Histologically, melanotic neuroectodermal tumor of infancy usually consists of 2 types of cells: neuroblast-like and melanocyte-like cells. Here we present a rare case of melanotic neuroectodermal tumor of infancy containing a third type of cell population, that is, rhabdomyoblasts in addition to the above two. Read More

View Article and Full-Text PDF
January 2021

Oral pigmented lesions: a retrospective analysis from Brazil.

Med Oral Patol Oral Cir Bucal 2021 May 1;26(3):e284-e291. Epub 2021 May 1.

Department of Oral Diagnosis and Pathology Federal University of Rio de Janeiro School of Dentistry Av. Carlos Chagas Filho 373, Prédio do CCS, Bloco K, 2° andar, Sala 56 Ilha da Cidade Universitária, Rio de Janeiro/RJ. 21.941-902

Background: Pigmented lesions are uncommon in the oral mucosa, and studies investigating the incidence and types of these lesions are desired to improve the diagnostic knowledge of clinicians. The aim of this study was to analyze the distribution of oral pigmented lesions in a Brazilian population.

Material And Methods: A retrospective descriptive cross-sectional study was performed. Read More

View Article and Full-Text PDF

Appendageal tumors and tumor-like lesions of the testis and paratestis: a 32-year experience at a single institution.

Hum Pathol 2020 09 30;103:25-33. Epub 2020 Jun 30.

Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:

The testicular hilum and paratestis contain several embryologically diverse anatomic structures, including the spermatic cord, tunica vaginalis, epididymis, rete testis, and several other embryonic remnants. Several benign and malignant lesions arise from these morphologically distinct structures, and owing to their proximity, it is challenging to classify and subsequently stage these tumors. Herein, we conducted a retrospective review of the paratesticular appendageal and rete testis tumors and tumor-like lesions diagnosed at our department from 1985 to 2016. Read More

View Article and Full-Text PDF
September 2020

Ototoxicity after platinum-based chemotherapy in the treatment of melanotic neuroectodermal tumour of infancy.

Oncol Lett 2020 May 5;19(5):3411-3416. Epub 2020 Mar 5.

Department of Maxillofacial Orthopaedics and Orthodontics, University of Medical Sciences, 60-780 Poznań, Poland.

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare infantile tumor that originates from mesenchymal-neuroectodermal cells, the treatment of which uses platinum derivatives that can affect hearing loss. The present study evaluated the long-term effects of ototoxicity following chemotherapy with cisplatin, vincristine, cyclophosphamide, teniposide and adriamycin in a 10-year-old patient after surgical removal of a MNTI tumor at the age of 8 months. Audiometric tests (high-frequency tonal audiometry, speech audiometry, speech acoustics, tympanometry and absorbance measurements) were performed during a 10-year follow-up after receiving chemotherapy. Read More

View Article and Full-Text PDF

Melanotic Neuroectodermal Tumor of Infancy, a Rapidly Growing Maxillary Alveolar Mass: A Case Report.

J Dent (Shiraz) 2020 Mar;21(1):77-80

Dept. of Periodontics, Dental School of Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Melanotic neuroectodermal tumor of infancy is a rare, rapidly growing, painless, pigmented neoplasm with neural crest derivation. It usually occurs during the first year of life and there is a prominent predilection for the maxilla. The purpose of the present report is to describe additional case of melanotic neuroectodermal tumor of infancy of maxilla in a 6-month-old infant male. Read More

View Article and Full-Text PDF

Melanotic Neuroectodermal Tumor of Infancy: A Rare Case Report.

Cureus 2019 Dec 31;11(12):e6521. Epub 2019 Dec 31.

Department of Pathology, Mahatma Gandhi Medical College & Hospital, Jaipur, IND.

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare pigmented neoplasm of neural crest origin that most commonly arises in the maxilla of neonates and infants during the first year of life. We report the case of a three-month-old female child who presented with a 15-day history of intraoral swelling. Radiologically, the tumor was detected in the right maxilla, which was removed by wide local excision. Read More

View Article and Full-Text PDF
December 2019

Melanotic neuroectodermal tumor of infancy to the skull: case-based review.

Childs Nerv Syst 2020 04 17;36(4):679-688. Epub 2020 Jan 17.

Department of Neurosurgery, University Hospital of Basel, Basel, Switzerland.

Background: Melanotic neuroectodermal tumor of infancy (MNTI) is a rare tumor, which usually occurs in infants under the age of one. Early diagnosis and radical surgery seem to be critical for long-term cure.

Case Presentation: We describe a case of a 4-month-old boy with a MNTI to the skull. Read More

View Article and Full-Text PDF

Melanotic neuroectodermal tumor of infancy arising from the skull: report of an unusual case, review of the literature, and a diagnostic approach.

Childs Nerv Syst 2020 03 3;36(3):469-475. Epub 2020 Jan 3.

Neurosurgery Department, Pediatric Hospital "Prof. Dr. Juan P. Garrahan", Buenos Aires, Argentina.

Introduction: Melanotic neuroectodermal tumor of infancy is a rare neoplasm mainly seen in children under 1 year of life. The most common location of the tumor is the maxilla followed by the cranial vault. Surgery is the treatment of choice and outcome mainly depends on extent of resection. Read More

View Article and Full-Text PDF

Melanotic neuroectodermal tumor of infancy in ovary: A rare case report.

Medicine (Baltimore) 2019 Dec;98(49):e18181

Department of Pediatric Surgery, Hunan Children's Hospital.

Rationale: Melanotic neuroectodermal tumor of infancy (MNTI) is an extremely rare benign pigmented neoplasm of neural crest origin with rapid expansile growth and a high recurrence rate. It is predominantly found in infants of <1 year of age, involvement of the head-and-neck region is the most common presentation though it is reported at other sites including mediastinum, shoulder, thigh, foot, epididymis, uterus and ovary. The patient reported here is the third case of MNTI presenting in an ovary, and the first reported in the infant ovary. Read More

View Article and Full-Text PDF
December 2019

Melanotic neuroectodermal tumour of infancy presenting as a lytic lesion in femur: a rare tumour at a rare site with an unusual behaviour.

BMJ Case Rep 2019 Oct 5;12(10). Epub 2019 Oct 5.

Orthopaedics, All India Institute of Medical Sciences, New Delhi, India.

Melanotic neuroectodermal tumour of infancy (MNTI) is an uncommon tumour, predominantly occurring in head and neck, mostly maxilla, but also in skull and mandible. Although a benign lesion, it is known to recur in 15%-27% of cases, and rarely, may undergo malignant transformation. We present a case of a 5-month-old female patient, who presented with a gradually progressive swelling in the right thigh. Read More

View Article and Full-Text PDF
October 2019