3,065 results match your criteria Melanotic Neuroectodermal Tumor of Infancy


Moxifloxacin as an inducer of apoptosis in melanoma cells: A study at the cellular and molecular level.

Toxicol In Vitro 2018 Dec 4;55:75-92. Epub 2018 Dec 4.

Medical University of Silesia, School of Pharmacy with the Division of Laboratory Medicine, Department of Pharmaceutical Chemistry, Jagiellońska 4, 41-200 Sosnowiec, Poland.

Fluoroquinolones were shown to be cytotoxic towards various cancer cell lines, thus representing a potentially important source of new anticancer agents. The aim of the present study was to examine the effect of moxifloxacin on cell viability, redox balance and apoptosis in both amelanotic - C32 and melanotic - COLO829 melanoma cells. Herein, we found that moxifloxacin decreases the viability of C32 and COLO829 cells in concentration- and time-dependent manner. Read More

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December 2018

UBIAD1 suppresses the proliferation of bladder carcinoma cells by regulating H-Ras intracellular trafficking via interaction with the C-terminal domain of H-Ras.

Cell Death Dis 2018 Dec 5;9(12):1170. Epub 2018 Dec 5.

Department of Genetics and Developmental Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.

UbiA prenyltransferase domain-containing protein 1 (UBIAD1) plays a key role in biosynthesis of vitamin K and coenzyme Q10 using geranylgeranyl diphosphate (GGPP). However, the mechanism by which UBIAD1 participates in tumorigenesis remains unknown. This study show that UBIAD1 interacts with H-Ras, retains H-Ras in the Golgi apparatus, prevents H-Ras trafficking from the Golgi apparatus to the plasma membrane, blocks the aberrant activation of Ras/MAPK signaling, and inhibits the proliferation of bladder cancer cells. Read More

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December 2018
5 Reads

Melanotic neuroectodermal tumour of infancy: A report of two cases.

Int J Surg Case Rep 2018 Nov 15;53:337-344. Epub 2018 Nov 15.

Nasser Institute Hospital for Research and Treatment, Cairo, Egypt; Department of Oral & Maxillofacial Surgery, Faculty of Oral and Dental Medicine, Cairo University, Egypt. Electronic address:

Introduction: Melanotic neuroectodermal tumour of infancy (MNTI) is a benign tumour of infancy, most commonly affecting the head and neck region. First described in 1918, less than 500 cases have been reported in the literature. MNTI is aggressive in nature & has a high rate of recurrence. Read More

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November 2018
3 Reads

Melanotic Neuroectodermal Tumor of Infancy: a Clinicopathological Case Report.

Braz Dent J 2018 Jul-Aug;29(4):400-404

Department of Oral Diagnosis, Piracicaba Dental School, UNICAMP - Universidade de Estadual de Campinas, Piracicaba, SP, Brazil.

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm that affects mainly children under 1 year of age. A 4-month-old boy was referred for evaluation of a lesion with 1 month of evolution. Intra-oral examination detected a firm upon palpation submucosal nodular mass, measuring 1. Read More

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December 2017
2 Reads

Non-invasive dynamic assessment of conjunctival melanomas by photoacoustic imaging.

Exp Eye Res 2018 Nov 14;179:157-167. Epub 2018 Nov 14.

Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Ophthalmology and Vision Sciences, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Physics, Faculty of Science, Ryerson University, Toronto, Ontario, Canada; Faculty of Engineering and Architectural Science, Ryerson University, Toronto, Ontario, Canada; Institute of Biomedical Engineering, Science and Technology (iBEST), St. Michael's Hospital, Ryerson University, Toronto, Ontario, Canada. Electronic address:

This study describes non-invasive photoacoustic imaging to detect and monitor the growth of conjunctival melanomas in vivo. Conjunctival melanomas were induced by injection of melanotic B16F10 cells into the subconjunctival space in syngeneic albino C57BL/6 mice. Non-invasive in vivo photoacoustic tomography was performed before, and after tumor induction up to 2 weeks. Read More

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November 2018
4 Reads

Carney Complex.

Exp Clin Endocrinol Diabetes 2018 Nov 14. Epub 2018 Nov 14.

Section on Endocrinology and Genetics & Endocrinology Inter-institute Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA.

Carney complex is a rare, autosomal dominant, multiple endocrine neoplasia and lentiginosis syndrome, caused in most patients by defects in the gene, which encodes the regulatory subunit type 1α of protein kinase A. Inactivating defects of lead to aberrant cyclic-AMP-protein kinase A signaling. Patients may develop multiple skin abnormalities and a variety of endocrine and non-endocrine tumors. Read More

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November 2018
3 Reads

Melanotic Neuroectodermal Tumor of Infancy.

Arch Pathol Lab Med 2018 Nov;142(11):1358-1363

From the Divisions of Anatomic and Clinical Pathology (Dr Soles) and Anatomic Pathology (Drs Wilson and Lucas), Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor.

Context.—: Melanotic neuroectodermal tumor of infancy, albeit rare and generally regarded as benign, is an important tumor to recognize because of its rapid growth, potential for local recurrence, and small round blue cell morphology, which can lead to misdiagnosis of a malignant neoplasm.

Objective. Read More

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November 2018
4 Reads

Primary malignant melanotic melanoma and hypomelanotic melanoma of the female urethra: case series and a review of the literature in China.

Melanoma Res 2018 Nov 2. Epub 2018 Nov 2.

The incidence of primary malignant melanoma (MM) of female urethra is extremely low, leading to paucity of recommendations on management. The objectives of our study were to gain more insight into the clinical features, diagnosis, treatment, and prognosis of this rare type of tumor. We carried out a retrospective analysis of all four cases who underwent an operation in our hospital since 1980. Read More

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November 2018
4 Reads

Epididymal melanotic neuroectodermal tumor of infancy: A rare cause of scrotal mass in an infant.

J Clin Ultrasound 2018 Nov 5. Epub 2018 Nov 5.

Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada.

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, benign neoplasm of neural crest origin more commonly seen in the craniofacial region. We report a case of MNTI of the epididymis in a 6-month-old male child with emphasis on the sonographic appearance which has not been previously described. In this case, the mass was inseparable from the testicle and therefore the differential diagnosis considered both extratesticular and intratesticular masses. Read More

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November 2018
4 Reads

Melanotic Neuroectodermal Tumor of Infancy: Case Report and Review of Management.

J Oral Maxillofac Surg 2018 Oct 5. Epub 2018 Oct 5.

Professor and Vice Chairman, Department of Oral and Maxillofacial Surgery, University of Maryland School of Dentistry, Baltimore, MD.

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare pigmented tumor of the head and neck, which most commonly presents during the first year of life. Most cases present in the bones of the craniofacial region, including the maxilla (60.3%), skull (18. Read More

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October 2018
6 Reads

Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence.

Head Neck 2018 Nov 2. Epub 2018 Nov 2.

Oral Surgery and Pathology Department, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Pará, Brazil.

The aim of the present study was to integrate the available data published on melanotic neuroectodermal tumor of infancy (MNTI) of the jaw bones. An electronic search was undertaken in April 2018. Hundred forty-seven publications and 371 patients were included. Read More

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November 2018
3 Reads

Dermoscopy of venous lake on the lips: A comparative study with labial melanotic macule.

Authors:
Ji Su Lee Je-Ho Mun

PLoS One 2018 31;13(10):e0206768. Epub 2018 Oct 31.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

Background: Venous lake (VL) is a common vascular tumor occurring on the lips in the elderly. VL is sometimes difficult to distinguish from melanotic lesions such as labial melanotic macule (LMM) or oral malignant melanoma. However, the dermoscopic features of VL have not been sufficiently established in the literature. Read More

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October 2018
2 Reads

Melanization of Bomirski hamster amelanotic melanoma cells (Ab line) depends on the type of culture medium.

Folia Histochem Cytobiol 2018 Oct 29. Epub 2018 Oct 29.

Department of Embryology, Medical Umiversity of Gdansk, Debinki 1 St, 80-210 Gdansk, Poland.

Introduction: The effect of melanogenesis intensity on melanoma biology remains an open question, and the biological differences between melanotic and amelanotic melanoma cells have not yet been satisfactorily documented. As a result, the melanization of melanoma cells in in vitro cultures is not considered among experimental procedures. The aim of this study was to investigate the effect of the medium used to culture Bomirski amelanotic Ab melanoma cells on the melanogenesis process. Read More

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October 2018
6 Reads

Novel therapeutic compound acridine-retrotuftsin action on biological forms of melanoma and neuroblastoma.

J Cancer Res Clin Oncol 2018 Oct 26. Epub 2018 Oct 26.

Department of Organic Chemistry, Gdansk University of Technology, Narutowicza St 11/12, 80-233, Gdansk, PL, Poland.

Purpose: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO)-Pro-Lys-Thr-OCH]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocytes, neurons) of neuroectodermal origin, and both are tumors with high heterogeneity and unsatisfactory susceptibility to chemotherapies. Thus, we analyzed the action of ART on pairs of biological forms of melanoma (amelanotic and melanotic) and neuroblastoma (dopaminergic and cholinergic) with regard to proliferation, mechanism of cell death, and effect on the activity of tricarboxylic acid cycle (TAC) enzymes. Read More

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October 2018
4 Reads

The zebrafish orthologue of familial Alzheimer's disease gene PRESENILIN 2 is required for normal adult melanotic skin pigmentation.

PLoS One 2018 25;13(10):e0206155. Epub 2018 Oct 25.

University of Adelaide, School of Biological Sciences, Alzheimer's Disease Genetics Laboratory, North Terrace, Adelaide, South Australia, Australia.

Alzheimer's disease is the most common form of age-related dementia. At least 15 mutations in the human gene PRESENILIN 2 (PSEN2) have been found to cause familial Alzheimer's disease (fAD). Zebrafish possess an orthologous gene, psen2, and present opportunities for investigation of PRESENILIN function related to Alzheimer's disease. Read More

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October 2018

The management of locally advanced head and neck squamous and basal cell carcinomas.

J BUON 2018 Jul-Aug;23(4):1118-1124

Plastic Surgery Clinic, "Agios Savvas" General Anticancer-Oncologic Hospital, Athens, Greece.

Purpose: The management of locally advanced head and neck basal (BCC) and squamous cell (SCC) carcinomas has been controversial and often debated. The purpose of the current study was to present our experience in the treatment of non-melanotic head and neck skin malignancies.

Methods: From 2000 to 2017, 34 patients with locally advanced head and neck skin tumors were treated in our hospital with wide local excision and immediate reconstruction mainly with rotational flaps, free tissue transfers and skin grafting. Read More

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October 2018
12 Reads

Pigmented Lesions of the Nail Unit.

Am J Dermatopathol 2018 Nov;40(11):793-804

Faculty in Dermatopathology, Department of Dermatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.

Pigmented lesions of the nail unit are commonly encountered in the clinical setting. Yet, they often present a unique challenge to clinicians because of a broad differential diagnosis or unfamiliarity with clinical and histopathologic features. A wide variety of causes exist ranging from benign lesions such as subungual hemorrhage to malignant lesions such as subungual melanoma. Read More

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November 2018
2 Reads

Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents.

Med Chem 2018 Oct 15. Epub 2018 Oct 15.

Department of Organic Chemistry, Gdansk University of Technology, Narutowicza St 11/12, PL 80-233 Gdansk. Poland.

Background: The lack of efficacious therapy for advanced melanoma and neuroblastoma makes new approaches necessary. Therefore, many scientists seek new, more effective, more selective and less toxic anticancer drugs.

Objective: We propose the synthesis of the new functionalized analogs of 1-nitroacridine/4-nitroacridone connected to tuftsin/retro-tuftsin derivatives as potential anticancer agents. Read More

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October 2018
6 Reads

[Lentigo maligna and lentigo maligna melanoma: a clinicopathologic analysis of twenty-four cases].

Zhonghua Bing Li Xue Za Zhi 2018 Oct;47(10):769-774

Department of Pathology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

To study the clinicopathologic features, differential diagnosis and prognosis of lentigo maligna (LM) and lentigo maligna melanoma (LMM). Histopathologic evaluation and immunohistochemical study by HRP multimer method were carried out in 24 cases of LM and LMM from 2012 to 2017 at Fudan University Shanghai Cancer Center. The clinical information and follow-up data were analyzed. Read More

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October 2018
5 Reads

Primary mediastinal melanotic schwannian tumors: A clinicopathological and immunohistochemical study of 5 cases.

Ann Diagn Pathol 2018 Oct 3;37:103-106. Epub 2018 Oct 3.

Department of Pathology of the University of Texas, MD Anderson Cancer Center, Houston, TX, United States of America.

Mediastinal neurogenic tumors are unusual and more so is the presence of melanotic neurogenic tumors. We present five cases of mediastinal melanotic neurogenic tumors. The patients are five men between the ages of 34 and 43 years (average: 38. Read More

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October 2018
6 Reads

Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier-Hunziker syndrome.

World J Clin Cases 2018 Sep;6(10):322-334

Department of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, Jiangsu Province, China.

Labial and oral melanotic macules are commonly encountered in a broad range of conditions ranging from physiologic pigmentation to a sign of an underlying life-threatening disease. Although Laugier-Hunziker syndrome (LHS) shares some features of labial and oral pigmentation with a variety of conditions, it is a benign and acquired condition, frequently associated with longitudinal melanonychia. Herein, the demographic, clinical, dermoscopic, and pathological aspects of LHS were reviewed comprehensively. Read More

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September 2018
2 Reads

Melanotic Schwannoma of Spine: Illustration of Two Cases with Diverse Clinical Presentation and Outcome.

Asian J Neurosurg 2018 Jul-Sep;13(3):881-884

Department of Pathology, Government Medical College, Thiruvananthapuram, Kerala, India.

Melanotic schwannomas (MS) are rare variants of schwannomas the occurrence of which is described in case reports only. They usually arise from posterior spinal nerve roots and less commonly from other cells of neural crest origin. Although they are relatively benign tumors in young, aggressive behavior is reported. Read More

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October 2018
2 Reads

A Rare Case of Melanotic Schwannoma: Utility of Susceptibility Weighted Sequences in Preoperative Imaging.

Cureus 2018 Jul 30;10(7):e3068. Epub 2018 Jul 30.

Neuroradiology, Prince Sultan Military Medical City, Riyadh, SAU.

Intracranial schwannomas account for 8% of all intracranial tumors, out of which 90% are acoustic schwannomas. Other rare varieties include trigeminal melanotic schwannomas that account for 0.2% of all intracranial tumors. Read More

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July 2018
1 Read

Diagnostic Difficulties in Primary Pauci-Melanotic Leptomeningeal Melanomatosis.

Eur Neurol 2018 19;80(1-2):68-70. Epub 2018 Sep 19.

Department of Pathomorphology and Oncologic Cytology, Wroclaw Medical University, Wroclaw, Poland.

We present a rare case of primary malignant melanoma of the central nervous system. We underline the difficulties we faced during diagnostic procedures. Finally, postmortem examination revealed the diagnosis of primary pauci--melanotic leptomeningeal melanomatosis. Read More

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September 2018
3 Reads

Unilateral retinoblastoma with contralateral isolated choroidal Melanocytosis: case report of an unexpected presentation.

BMC Ophthalmol 2018 Sep 17;18(1):251. Epub 2018 Sep 17.

Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Background: Congenital ocular melanocytosis has been shown to be extremely uncommon in studies of numerous infants and children with retinoblastoma and disorders such as retinopathy of prematurity.

Case Presentation: A 33-month-old Caucasian boy presented with a solid white predominantly endophytic retinoblastoma filling most of the nasal aspect of the fundus and extensive vitreous seeding. Fundus exam of the contralateral eye showed a broad-based flat melanotic area of the choroid extending from the subfoveal region to the ora serrata temporally. Read More

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September 2018
1 Read

Shunt Surgery for Neurocutaneous Melanosis with Hydrocephalus: Case Report and Review of the Literature.

World Neurosurg 2018 Dec 8;120:583-589.e3. Epub 2018 Sep 8.

Section of Neurosurgery, Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Philippines. Electronic address:

Background: Neurocutaneous melanosis is a rare phakomatosis characterized by large or multiple pigmented nevi and melanosis of the leptomeninges. It is often complicated by hydrocephalus due to melanotic deposits interfering with cerebrospinal fluid reabsorption in the basal cisterns or causing foraminal or aqueductal obstruction. In 10% of cases, it will be associated with the Dandy-Walker complex. Read More

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December 2018
4 Reads

Melanotic neuroectodermal tumor of infancy: A rare pediatric head and neck lesion.

Pediatr Dermatol 2018 Nov 4;35(6):e389-e390. Epub 2018 Sep 4.

Department of Dermatology, University of New Mexico, Albuquerque, New Mexico.

Melanotic neuroectodermal tumors of infancy are rare tumors arising from the neural crest and typically present during the first 12 months of life. The majority involve the facial bones, although melanotic neuroectodermal tumors of infancy of the skull and extremities have been observed with less frequency, as in the present case. This entity may initially be presented to the dermatologist as a scalp mass and should be considered in the differential diagnosis of infants with rapidly growing head and neck lesions. Read More

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November 2018
6 Reads

Melanotic neuroectodermal tumour of infancy of the jaws: an analysis of diagnostic features and treatment.

Int J Oral Maxillofac Surg 2018 Aug 28. Epub 2018 Aug 28.

Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

The purpose of this study was to integrate the available published data on melanotic neuroectodermal tumour of infancy (MNTI) of the jaws into a comprehensive analysis of its clinical/radiological features, with emphasis on the predictive factors associated with recurrence. Eligibility criteria included publications with sufficient clinical/radiological/histological information to confirm the diagnosis. A total of 288 publications reporting 429 MNTI cases were included. Read More

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Aggressive histologic features do not predict biologic behavior in melanotic neuroectodermal tumor of infancy.

J Oral Maxillofac Pathol 2018 May-Aug;22(2):260-262

Department of Surgical and Hospital Dentistry, University of Louisville School of Dentistry, Louisville, Kentucky, USA.

While generally benign, occasional aggressive histologic features in the melanotic neuroectodermal tumor of infancy (MNTI) have been used to justify a diagnosis of malignancy; this could lead to overtreatment. We report a case with presumed aggressive histologic features that did not recur following conservative treatment. This adds evidence that histologic features are not predictive of clinical behavior in MNTI. Read More

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Late effects in high-risk neuroblastoma survivors treated with high-dose chemotherapy and stem cell rescue.

Pediatr Blood Cancer 2019 Jan 27;66(1):e27421. Epub 2018 Aug 27.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Background: Current treatment strategies have improved the outcome of high-risk neuroblastoma (HRNB) at the cost of increasing acute and late effects of treatment. Although high-dose chemotherapy with stem cell rescue (HDC-SCR) has replaced total body irradiation (TBI) based HRNB therapy, late effects of therapy remain a significant concern.

Objectives: To describe late effects prevalence, severity, and risks after HDC-SCR. Read More

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January 2019
3 Reads

A Rare Report of Lung Metastasis of the Common Non-Melanotic Skin Cancer.

Tanaffos 2018 Jan;17(1):62-65

Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Basal cell carcinoma is a common non-melanotic skin cancer with a prevalence of 74.5%-82.6% in the Iranian population. Read More

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January 2018
31 Reads

Pigmented (melanotic) diffuse neurofibroma of the back in neurofibromatosis type 1.

GMS Interdiscip Plast Reconstr Surg DGPW 2018 3;7:Doc04. Epub 2018 Aug 3.

Institute of Neuropathology, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany.

Neurofibromatosis type 1 (NF1) is a tumor predisposition disease. Multiple neurofibromas are among the characteristic tumors of NF1. The report describes the diagnosis and treatment of a large spinal neurofibroma in a NF1 patient. Read More

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August 2018
2 Reads

Development of a peptide-based bifunctional chelator conjugated to a cytotoxic drug for the treatment of melanotic melanoma.

Medchemcomm 2018 May 6;9(5):812-826. Epub 2018 Mar 6.

Infectious Diseases and Immunology Division , CSIR-Indian Institute of Chemical Biology , Kolkata , India . Email:

The cytotoxic drug gemcitabine (GEM) has been conjugated to receptor-binding peptides to target melanoma tumors. A hexapeptide having a Lys-Gly-His-Lys sequence (pep-1), an octapeptide with an Arg-Gly-Asp-Lys-Gly-His-Lys sequence (pep-2), a GEM-conjugated Lys-Gly-His-Lys peptide (GEM-pep-3) and a GEM-conjugated Asp-Gly-Arg peptide (GEM-pep-4) were synthesized and characterized. uptake of fluorescently labeled GEM-pep-3 and GEM-pep-4 on B16F10 cells was investigated. Read More

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May 2018
1 Read
2.500 Impact Factor

Melanotic Xp11 translocation renal cancer: a report of a distinctive case and a review of the literature.

Diagn Pathol 2018 Aug 13;13(1):51. Epub 2018 Aug 13.

Department of Pathology, Shandong Cancer Hospital Affiliated to Shandong University, No. 440 Jiyan Road, Jinan, 250117, China.

Background: Melanotic Xp11 translocation renal cancer (TRC) is a newly described exceedingly rare tumor, and its characterization remains controversial. This study aimed to describe a case of distinctive melanotic Xp11 TRC and to elucidate its clinicopathological and molecular genetic features.

Case Presentation: A 44-year-old Chinese female presented with a left renal mass. Read More

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Inflammatory juvenile compound nevi: A melanoma is not all that it appears to be.

Arch Soc Esp Oftalmol 2018 Aug 8. Epub 2018 Aug 8.

Servicio de Córnea y Cirugía Refractiva, Asociación Para Evitar la Ceguera en México, Ciudad de México, México.

An 11 year-old girl presented with a recent growth pigmented conjuntival lesion in the bulbar conjunctiva of left eye. Due to the the biomicroscopic and ultrasound findings, an excisional biopsy was performed on the lesion using the «no touch» technique, as well as cryo-coagulation of surgical margins. Histopathological examination revealed an inflammatory compound nevus. Read More

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August 2018
2 Reads

Combination of label-free quantitative proteomics and transcriptomics reveals intraspecific venom variation between the two strains of Tetrastichus brontispae, a parasitoid of two invasive beetles.

J Proteomics 2018 Aug 8. Epub 2018 Aug 8.

State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Fujian Provincial Key Laboratory of Insect Ecology, Department of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China. Electronic address:

The venom apparatus is a conserved organ in parasitoids that shows adaptations correlated with life-style diversification. Combining transcriptomics and label-free quantitative proteomics, here we explored the venom apparatus components of the endoparasitoid Tetrastichus brontispae (Eulophidae), and provide a comparison of the venom apparatus proteomes between its two closely related strains, T. brontispae-Octodonta nipae (Tb-On) and T. Read More

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August 2018
1 Read

Laugier-Hunziker syndrome in endocrine clinical practice.

Endocrinol Diabetes Metab Case Rep 2018 26;2018. Epub 2018 Jul 26.

Departments of Endocrinology, Diabetes and Metabolic Diseases.

Laugier-Hunziker syndrome (LHS) is a rare, benign and acquired disorder characterized by hyperpigmentation of the oral cavity and lips along with longitudinal melanonychia. No underlying systemic abnormalities or malignant predisposition is associated with it. In everyday clinical practice, an endocrinologist encounters certain endocrine conditions (e. Read More

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July 2018
9 Reads

Clinical characteristics and preliminary morphological observation of 47 cases of primary anorectal malignant melanomas.

Melanoma Res 2018 Dec;28(6):592-599

Department of Pathology, Tianjin Union Medical Center.

The clinical data and paraffin-embedded samples of 47 cases of primary anorectal malignant melanomas (ARMMs) detected from 2004 to 2017 were collected to investigate the clinicopathological characteristics. The ARMMs were grouped according to tumour size, appearance of melanin granules in the plasma of the tumour cell, linearly patterned programmed cell necrosis (LPPCN) in tumour tissue and lymph node metastasis. On the basis of size, these tumours were divided into two groups: group I (volume of tumour >20 cm, or minimal diameter >1 cm and volume of tumour <20 cm, but >10 cm) and group II (volume of tumour <20 cm and minimal diameter <1 cm). Read More

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December 2018
1 Read

New insights into neurocutaneous melanosis.

Pediatr Radiol 2018 Nov 3;48(12):1786-1796. Epub 2018 Aug 3.

Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, 505 Parnassus Ave., San Francisco, CA, 94143-0628, USA.

Background: Neurocutaneous melanosis is a rare disorder in which children with large cutaneous melanotic nevi have associated melanosis in the brain. Although many affected children have structurally normal brains, some have associated developmental disorders or brain anomalies.

Objectives: To determine the range of extent of brain melanosis as assessed by magnetic resonance imaging (MRI) and to investigate the frequency and types of associated brain anomalies. Read More

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November 2018
2 Reads

Caffeine modulates growth and vitality of human melanotic COLO829 and amelanotic C32 melanoma cells: Preliminary findings.

Food Chem Toxicol 2018 Oct 27;120:566-570. Epub 2018 Jul 27.

Department of Pharmaceutical Chemistry, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Jagiellońska 4, 41-200, Sosnowiec, Poland.

Coffee is one of the most popular beverages consumed worldwide and therefore even small effects of coffee bioactive compounds on cellular homeostasis could have a large impact on public health. Recent cohort health studies have shown an impressive inverse correlation between caffeinated coffee consumption and malignant melanoma risk. The aim of presented study was to examine the effect of caffeine on cell viability and glutathione status of melanotic (COLO829) and amelanotic (C32) melanoma cell lines as well as normal human melanocytes. Read More

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October 2018

Intracranial Melanotic Schwannomas: Rare and Distinctive Tumors to Know Due to their Risk of Recurrence and Metastases.

J Belg Soc Radiol 2018 Jan 31;102(1):15. Epub 2018 Jan 31.

Clinique Saint-Pierre Ottignies, BE.

Melanotic schwannomas are rare nerve sheath tumors that differentiate themselves from classical schwannomas by harboring melanin-producing cells. Intracranial localizations are uncommon, especially on the Gasserian ganglion. We performed a literature review, presenting imaging characteristics, differential diagnosis, and immunohistochemical features for identification. Read More

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January 2018
1 Read

Pigmented lesions of the oral mucosa: A cross-sectional study of 458 histopathological specimens.

Oral Dis 2018 Nov 10;24(8):1484-1491. Epub 2018 Jul 10.

Department of Oral Pathology and Surgery, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Objectives: To evaluate clinical, demographic, and histopathological characteristics of pigmented lesions of the oral mucosa.

Materials And Methods: A cross-sectional study was conducted over a 64-year period. Information was collected from medical charts, and all archived histopathological specimens with diagnoses of any pigmented lesion were retrieved. Read More

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November 2018
2 Reads

Staged margin-controlled excision (SMEX) for lentigo maligna melanoma in situ.

J Surg Oncol 2018 Jul 24;118(1):144-149. Epub 2018 Jun 24.

Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Background: No consensus exists regarding the best surgical strategy to achieve clear surgical margins while minimizing tissue excision when definitely excising lentigo maligna melanoma in situ (LM). The staged margin controlled excision (SMEX) technique is a modification of the spaghetti technique that allows surgeons to minimize margins and ensure complete excision of LM.

Objectives: Our objectives were twofold: a) to evaluate the effectiveness of SMEX for treatment of LM and b) detail the SMEX technique. Read More

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July 2018
2 Reads

Melanoma: clinical, evolutive and histopathological characteristics of a series of 136 cases.

An Bras Dermatol 2018 Jun;93(3):373-376

Department of Pathology, Universidade Estadual Paulista, Botucatu, SP, Brazil.

Background: The incidence of melanoma has been increasing in Brazil and all over the world. Despite improvements in diagnosis and treatment, mortality remains unchanged.

Objective: To associate clinical and histopathological aspects with the evolution of 136 cases of cutaneous melanoma. Read More

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June 2018
3 Reads

Prevalence and Distribution of Oral Mucosal Lesions by Sex and Age Categories: A Retrospective Study of Patients Attending Lebanese School of Dentistry.

Int J Dent 2018 17;2018:4030134. Epub 2018 May 17.

Faculty of Pharmacy, Lebanese University, Beirut, Lebanon.

Background: Prevalence and distribution of oral mucosal lesions in a sample of Lebanese population attending the School of Dentistry of Lebanese University is necessary to evaluate their oral health situation.

Objectives: The aim of the present study was to determine the prevalence and distribution of oral mucosal lesions of patients attending the School of Dentistry.

Methods: A descriptive study was carried out by retrospectively examining a total of 231 medical and clinical examination record files of patients, attending the School of Dentistry Lebanese University for multidisciplinary dental treatments. Read More

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May 2018
6 Reads

Acral Lentiginous Melanoma Is Associated with Certain Poor Prognostic Histopathological Factors but May Not be Correlated with Nodal Involvement, Recurrence, and a Worse Survival.

Pathobiology 2018 1;85(4):227-231. Epub 2018 Jun 1.

Background/aims: Acral lentiginous melanoma (ALM) is a small subtype of melanoma affecting Caucasians far more often than other ethnic groups, such as blacks, Hispanics, and Asians. Only a few studies have yielded controversial results on ALM so far. The aim of this study was to define the histopathological and clinical expressions of ALM and to compare them with those of non-ALM in a large group of Turkish patients from a single referral institution. Read More

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November 2018

Dermoscopic "Landscape Painting Patterns" as a Clue for Labial Melanotic Macules: An Analysis of 80 Cases.

Ann Dermatol 2018 Jun 23;30(3):331-334. Epub 2018 Apr 23.

Department of Dermatology, Pusan National University School of Medicine, Busan, Korea.

Background: Labial melanotic macules (LMMs) are benign pigmented lesions that usually take the shape of flat asymmetrical macules with tan-brown to black color and variable size. Whereas the dermoscopic features of other pigmented skin lesions have been relatively well described, little is known about LMMs.

Objective: To describe the dermoscopic features and find typical and schematic dermoscopic patterns in LMMs. Read More

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June 2018
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