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Int J Dermatol 2020 Jul 2. Epub 2020 Jul 2.

Departments of Dermatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.

J Cutan Pathol 2020 Jun 23. Epub 2020 Jun 23.

Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.

Introduction: Upto10% patients with lichen planus (LP) have nail involvement; still there is a paucity of studies on histopathological features. Nevertheless, nail biopsy is the diagnostic standard, especially for isolated nail LP.

Methodology: Nails of 45 patients with nail LP were evaluated clinically and biopsies taken from most involved nail (25 nail bed and 20 matrix biopsies). Read More

Indian J Dermatol 2020 May-Jun;65(3):193-198

Department of Dermatology, MLN Medical College, Allahabad, Uttar Pradesh, India.

Introduction: Nail toxicity is a relatively uncommon cutaneous adverse effect of chemotherapeutic agents. Rapidly dividing cells of the nail matrix are perturbed by the antimitotic activity of these agents. Although most of these changes are cosmetic and regress once the therapy is completed, a few of these adverse effects are challenging to manage and require temporary or permanent suspension of chemotherapeutic agents. Read More

Cureus 2020 May 3;12(5):e7946. Epub 2020 May 3.

Dermatology, San Diego Family Dermatology, National City, USA.

Onychomatricoma is a rare, benign nail matrix tumor. It most frequently occurs on one of the first three fingers of the dominant hand or the big toe in middle-aged women. Our patient presented with a 10-year history of a progressive thickening of her right great toenail; it bled easily and was intermittently painful. Read More

Postepy Dermatol Alergol 2020 Apr 10;37(2):195-201. Epub 2019 Sep 10.

Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, Gdańsk, Poland.

Introduction: Longitudinal melanonychia (LM) is characterized by a tan, brown or black longitudinal streak within nail plate caused by the presence of melanin. LM is relatively common in dark-skinned population, infrequent in Caucasian population, and rare in children.

Aim: We report epidemiological, clinicopathological and dermoscopic analysis of 8 cases of childhood LM from Poland, which is the largest series in the Central and Eastern European population. Read More

Postepy Dermatol Alergol 2020 Apr 5;37(2):180-183. Epub 2020 May 5.

Department of Dermatology and Venereology, Batman Medical Park Hospital, Batman, Turkey.

Introduction: There are very few studies about dermoscopic findings of fungal melanonychia (FM) apart from the case reports.

Aim: To reveal and identify dermoscopic findings which facilitate diagnosis of the FM.

Material And Methods: The study included a total of 42 nails from 33 patients diagnosed with FM on the basis of the clinical history, physical examination, dermoscopic findings and microbiological investigation. Read More

Indian Dermatol Online J 2020 Mar-Apr;11(2):195-201. Epub 2020 Mar 9.

Department of Skin and VD, SBH Govt. Medical College, Dhule, Maharashtra, India.

Introduction: Leprosy is a disease primarily affecting skin and nerve. Nail involvement, although indirect, is observed in several patients. This is a study to determine the pattern of nail changes in leprosy. Read More

Indian Dermatol Online J 2020 Mar-Apr;11(2):171-176. Epub 2020 Mar 9.

Department of Pathology, ESI-PGIMSR Hospital, Basaidarapur, Delhi, India.

Background And Aims: Melanonychia can be a manifestation of benign or malignant pathology and often poses a diagnostic challenge on clinical examination. Even with distinguishing dermoscopic features (nail plate), it can be quite difficult to determine the nature of pigmentation as complete assessment of nail bed and matrix is still not possible. Intraoperative dermoscopy (IOD) can serve as a useful tool to appreciate the bed and matrix changes. Read More

Ned Tijdschr Tandheelkd 2020 Apr;127(4):237-243

The medicament afamelanotide is an analogue of endogenous ?-melanocyte-stimulating hormone. It promotes cutaneous pigmentation, providing protection from sunlight. In dermatology, afamelanotide seems to establish therapeutic results for polymorphic light eruption, solar urticaria, erythropoietic protoporphyria, Hailey-Hailey disease, vitiligo and acne vulgaris. Read More

J Am Acad Dermatol 2020 May 18. Epub 2020 May 18.

Weill Cornell Medicine, Department of Dermatology, New York, NY.

J Am Acad Dermatol 2020 May 13. Epub 2020 May 13.

Weill Cornell Medicine, Department of Dermatology, New York, New York, USA.

J Eur Acad Dermatol Venereol 2020 Apr 22. Epub 2020 Apr 22.

Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Background: Longitudinal melanonychia (LM) can present a diagnostic challenge and dermoscopy is of utmost importance for its evaluation and differential diagnosis of LM.

Objective: This report aimed to describe an unusual dermoscopic pattern in a group of patients that presented with LM.

Methods: The clinical course and features of five LM patients that presented with an unusual 'zigzag' dermoscopic pattern were analyzed retrospectively. Read More

Histopathology 2020 Apr 20. Epub 2020 Apr 20.

Department of Pathology, First People's Hospital, Shanghai Jiaotong University, Shanghai, 200080, China.

Aims: Longitudinal melanonychia in pediatric patients often represents a difficult diagnostic challenge and studies emphasizing on its clinical and histopathologic features are limited due to its low incidence in childhood.

Methods And Results: We retrospectively analyzed 35 pediatric cases identified by excision specimens on their clinicopathologic features, and performed fluorescence in situ hybridization test on available 13 cases. Fingernails (77. Read More

JAAD Case Rep 2020 Apr 30;6(4):372-373. Epub 2020 Mar 30.

Department of Medicine, Centro Universitário de Caratinga, Caratinga, Brazil.

Case Rep Pediatr 2020 17;2020:8267805. Epub 2020 Mar 17.

Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, British Columbia V5Z 1K1, Canada.

Laugier-Hunziker syndrome is a rare, acquired disorder characterized by mucocutaneous hyperpigmentation and melanonychia striata with no underlying systemic abnormalities. We report an 8-year-old boy with Laugier-Hunziker syndrome who presented with melanonychia striata affecting all the fingernails and toenails, macular pigmentation on the tongue and the lower lip, and scleral melanocytosis. Melanonychia striata rarely affect all the twenty nails, and scleral melanocytosis has rarely been reported in association with Laugier-Hunziker syndrome. Read More

J Am Acad Dermatol 2020 Mar 19. Epub 2020 Mar 19.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.

Carpal tunnel syndrome (CTS) is commonly seen by general practitioners and often presents with neurologic symptoms of nocturnal pain and paresthesia along the median nerve distribution. Approximately 20% of patients also present with cutaneous findings (ulcerations, blistering, sclerodactyly, nail dystrophy) characterizing a severe form called necrotic CTS. Necrotic CTS can also be associated with bone changes (acro-osteolysis). Read More

An Bras Dermatol 2020 Mar - Apr;95(2):217-220. Epub 2020 Feb 12.

Dermatology Service, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Melanonychia is the change in the coloration of the nail plate resulting from the deposition of melanin. Among its causes are melanocytic hyperplasia, melanocytic activation and nail melanoma. Subungual follicular inclusions are histological findings of unknown etiology, possibly related to trauma. Read More

Cureus 2020 Jan 10;12(1):e6621. Epub 2020 Jan 10.

Oncologic Dermatology, Elias Emergency University Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU.

Melanonychia represents a brown to black discoloration of the nail plate that may be induced by benign or malignant causes. Two main mechanisms are involved in the appearance of melanonychias, i.e. Read More

Indian Dermatol Online J 2020 Jan-Feb;11(1):1-11. Epub 2020 Jan 13.

Department of Dermatology and STD, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.

Melanonychia is a very worrisome entity for most patients. It is characterized by brownish black discoloration of nail plate and is a common cause of nail plate pigmentation. The aetiology of melanonychia ranges from more common benign causes to less common invasive and in situ melanomas. Read More

Int J Dermatol 2020 Jun 10;59(6):e208-e209. Epub 2020 Feb 10.

DHM Pathology, Macquarie Park, NSW, Australia.

Cureus 2019 Dec 6;11(12):e6311. Epub 2019 Dec 6.

Medicine, State University of New York (SUNY) Downstate Medical Center, Brooklyn, USA.

Hydroxyurea (HU) is a commonly used medication for myeloproliferative neoplasm (MPN) and is usually well tolerated. Cutaneous toxicity of HU is well known and can be seen in several manifestations. We report a case of a man with MPL gene mutation associated with essential thrombocytosis, who had a rare mucocutaneous toxicity with diffuse tongue, skin and nail discoloration. Read More

Skinmed 2019 1;17(6):413-414. Epub 2019 Nov 1.

Department of Dermatology, University General Hospital of Patras, Patras, Greece.

A 35-year-old Greek woman (Fitzpatrick Skin Type IV) presented to our clinic 4 months after the delivery of her first child with nail changes that were first noted during pregnancy. During the 12th week of pregnancy, homogenous dark brown streaks appeared first on the nails of her right second and third fingers (Figure 1a, b) and later on her right fourth toenail (Figure 2a). During the following weeks, she developed similar changes on the second and fourth toenails (Figure 2b). Read More

Indian J Dermatol 2019 Nov-Dec;64(6):471-475

Department of Dermatology, B.J. Medical College and Civil Hospital, Ahmedabad, Gujarat, India.

Background: Targeted chemotherapeutic drugs have led to a remarkable improvement in the survival of cancer patients but also have resulted in the increased incidence of uncommon but specific muco-cutaneous adverse effects.

Aims: This study aimed to highlight the spectrum of such cutaneous adverse drug reactions and to derive a causal association.

Materials And Methods: A hospital-based, descriptive study was carried out in the dermatology outpatient department between August 2016 and July 2018, on patients referred from the state cancer institute, who developed muco-cutaneous lesions after the initiation of targeted chemotherapeutic drugs. Read More

Ann Dermatol Venereol 2020 Jan 4;147(1):18-28. Epub 2019 Dec 4.

Clinique dermatologique, université de Strasbourg et hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France. Electronic address:

Introduction: There are few studies focusing on ungual lesions in patients with lupus erythematosus (LE). The aim of this study is to describe the type and the prevalence of ungual lesions among LE patients.

Patients And Methods: A systematic literature review with analysis of individual data was performed by searching the MEDLINE database for scientific articles using the keywords "lupus erythematosus" and "nail". Read More

Photodermatol Photoimmunol Photomed 2020 03 10;36(2):163-165. Epub 2019 Dec 10.

Huang PH Dermatology and Aesthetics, Kaohsiung, Taiwan.

Postgrad Med J 2020 May 31;96(1135):296-297. Epub 2019 Oct 31.

Medicine, SRMSIMS, Bareilly, Uttar Pradesh, India.

JAMA Dermatol 2019 Oct 30. Epub 2019 Oct 30.

National Center for Children's Health, Department of Dermatology, Beijing Children's Hospital, Capital Medical University, Beijing, China.

Postgrad Med J 2020 Mar 9;96(1133):167. Epub 2019 Oct 9.

Neurology, Fortis Hospital Mohali, Mohali, Punjab, India

Pediatr Dermatol 2019 Nov 2;36(6):864-868. Epub 2019 Oct 2.

The National Skin Centre, Singapore City, Singapore.

Background And Objectives: Melanonychia striata is common in children of darker-skinned Asian races, while subungual melanoma is extremely rare and it is difficult to make a diagnosis clinically. However, performing nail unit biopsies in children is particularly challenging and can result in permanent nail dystrophy. The aim of this study was to review the clinical and histologic characteristics of melanonychia striata in pediatric patients of Asian descent to aid in the clinical decision regarding nail biopsy. Read More

Hand Surg Rehabil 2019 12 21;38(6):386-389. Epub 2019 Sep 21.

Department of plastic & reconstructive surgery, hand & microsurgery, American University of Beirut Medical Center, Cairo street, Beirut, Lebanon.

Pigmented onychomatricoma (OM) is a very rare benign fibroepithelial tumor of the nail matrix. We report the case of a 23-year-old Lebanese man with 15-year history of nail plate dystrophy with longitudinal ridging, yellowish discoloration, excessive transverse curvature and late-onset melanonychia along the medial third of the right thumb nail. Excisional biopsy was performed and confirmed OM. Read More

Taiwan J Obstet Gynecol 2019 Sep;58(5):709-711

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address:

Objective: Nail change after chemotherapy is relatively unfamiliar with gynecological oncologist. It often occurs after docetaxel treatment. For gynecological tract cancers, paclitaxel might be most frequently used but nail change after paclitaxel treatment is seldom reported before. Read More

Saudi J Kidney Dis Transpl 2019 Jul-Aug;30(4):978-981

Department of Nephrology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

Melanonychia is described as a brown to black pigmentation of nail, due to stimulation and hyperplasia of nail matrix. Various systemic disorders, trauma, inflammatory disorders, fungal infections, drugs, benign melanocytic hyperplasia, etc., are responsible for this condition, and most of them are benign. Read More

Am J Dermatopathol 2020 Feb;42(2):103-110

Laboratoire Central d'Anatomie Pathologique, Hôpital L. Pasteur, University of Nice, France.

This is a report of a previously undescribed type of onychomatricoma (OM) with an unusual clinical presentation as a thickened free edge of the nail plate without discernible cavities and distinguished histologically from the ordinary OM by 3 features: (1) the lack of cavitation at the proximal border of the nail plate and the small sizes of the cavities at the free edge of the distal nail plate; (2) a papillated epithelial hyperplasia pattern very different from the digitate pattern of the ordinary OM; and (3) a special pattern of matrical keratinization with pseudohorn cysts that mirror closely those found in onychocytic matricoma (OCM). Furthermore, the sex ratio and sites of the lesion seem different than those of conventional OM with the caveat that the numbers in this series are small. A practical approach to the diagnosis of onychogenic tumor mainly involves consideration of tumors that clinically present as localized longitudinal pachyonychia including melanoma and Bowen disease. Read More

J Dermatol 2019 Oct 25;46(10):911-913. Epub 2019 Jul 25.

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

A 73-year-old healthy woman noticed black pigmentation on both thumbnails for 6 years. Upon her visit to our clinic, she had pigmented onychomycosis with onycholysis in the distal area. There was no evidence of paronychia. Read More

Curr Health Sci J 2019 Jan-Mar;45(1):36-41. Epub 2019 Mar 31.

Medical Center Dr. Ianosi, Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, Romania.

Melanonychia is the brown or black color of the finger or toe nail due to melanin deposition or melanocytes in the nail plate. The evidence of melanocytic disease is made by the dermatoscope, which allows to highlight the anomalies of the plate. The purpose of our study was to evaluate dermatoscopically the melanonychia, both in the form of stain and longitudinal on finger and/or toe nails in order to establish the type of nail hyperpigmentation. Read More

J Eur Acad Dermatol Venereol 2019 Nov 3;33(11):e428. Epub 2019 Jul 3.

Departments of Dermatology, Pathology, Obstetrics and Gynecology, Urology, and Medical Research, China Medical University Hospital, Taichung, Taiwan.

Lupus 2019 Jul 19;28(8):1021-1026. Epub 2019 Jun 19.

2 Division of Rheumatology, University of the Witwatersrand, South Africa.

Background: Cutaneous involvement is very common in systemic lupus erythematosus. We describe the prevalence and spectrum of lupus-specific (cutaneous lupus erythematosus) and non-specific cutaneous features amongst mostly black South Africans with systemic lupus erythematosus.

Patients And Methods: A retrospective record review of 298 South Africans (262 blacks and 36 non-blacks) with systemic lupus erythematosus was carried out. Read More

Indian J Dermatol 2019 May-Jun;64(3):247-248

Department of Dermatology, University Hospital Dr. José Eleuterio González, Autonomous University of Nuevo Leon, Monterrey, México.

J Am Acad Dermatol 2019 May 23. Epub 2019 May 23.

An Bras Dermatol 2019 Mar-Apr;94(2):214-216. Epub 2019 May 9.

Center for Nail Research, Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro (RJ), Brazil.

Onychocytic matricoma is a newly described tumor of the nail matrix. Clinically, it presents with localized thickening of the nail plate and melanonychia. Histologically, it represents a benign acanthoma of onychocytes. Read More

Orthop Clin North Am 2019 Jul;50(3):357-366

Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15237, USA.

Subungual melanoma is a rare form of melanoma that presents a unique set of challenges largely based on the complex anatomy of the nail unit. Subungual melanoma often first appears with longitudinal melanonychia. Thus, practitioners must have a high clinical suspicion in any patient with longitudinal melanonychia and a low threshold for a biopsy. Read More

Int J Dermatol 2019 Nov 21;58(11):1239-1245. Epub 2019 Apr 21.

Departments of Pediatrics, Laboratory Medicine, and Pathology, The University of Alberta, Edmonton, Alberta, Canada.

Melanonychia striata is characterized by a tan, brown, or black longitudinal streak within the nail plate that runs from the proximal nail fold to the distal part of the nail plate. Melanonychia striata is due to increased activity of melanocytes or melanocytic hyperplasia in the nail matrix with subsequently increased melanin deposition in the nail plate. The most common cause of melanonychia striata associated with melanocytic activation is ethnic melanonychia which occurs in dark-skinned individuals. Read More

J Clin Rheumatol 2019 Apr 3. Epub 2019 Apr 3.

From the Allergy Immunology Unit, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

J Am Acad Dermatol 2019 Sep 28;81(3):717-722. Epub 2019 Mar 28.

Department of Dermatology, First Affiliated Hospital with Nanjing Medical University, Nanjing, China. Electronic address:

Background: Nail matrix histopathologic examination is still the criterion standard to diagnose longitudinal melanonychia (LM).

Objective: To introduce modified shave surgery combined with the nail window technique for managing LM and evaluate the postoperative outcome of the procedure.

Methods: We retrospectively reviewed the medical records of 67 patients with LM who underwent shave surgery combined with the longitudinal-strip nail window technique at our institution from March 2015 to June 2018. Read More

Ned Tijdschr Geneeskd 2019 03 11;163. Epub 2019 Mar 11.

Streekziekenhuis Koningin Beatrix, afd. Chirurgie, Winterswijk.

We present a 48-year-old man who had developed a skin lesion on his big toe. In 2 years' time, the lesion had evolved from melanonychia striata to an erratic, erosive, granulomatous plaque of approximately 3,0 x 3,0 cm. Histopathological examination of 2 skin biopsies revealed a nodular melanoma. Read More

Reumatologia 2019 28;57(1):63-65. Epub 2019 Feb 28.

Department of Dermatology and Venereology, Akdeniz University School of Medicine, Antalya, Turkey.

Laugier-Hunziker syndrome is a rare benign idiopathic condition characterized by acquired macular pigmentation of the lips and buccal mucosa, often accompanied by melanonychia. Although the etiopathogenesis is not fully known, tyrosine is thought to be responsible for the pathogenesis of enzyme hyperactivity in melanin biosynthesis. We present the case of a 66-year-old woman diagnosed with Laugier-Hunziker syndrome and rheumatoid arthritis. Read More

J Eur Acad Dermatol Venereol 2019 Sep 27;33(9):1800-1805. Epub 2019 Mar 27.

Department of Dermatology, Saint-Pierre, Brugmann and Queen Fabiola Children's University Hospitals, Université Libre de Bruxelles, Brussels, Belgium.

Background: Very few studies have been conducted to establish the nature and prevalence of nail disorders in children.

Objectives: To determine the frequency of various nail conditions in the paediatric setting and to report their management and follow-up.

Methods: This was a retrospective study between 2007 and 2017 of children under 18. Read More

Dermatol Pract Concept 2019 Jan 31;9(1):38-43. Epub 2019 Jan 31.

Department of Experimental, Diagnostic and Specialty Medicine-Division of_Dermatology, University of Bologna, Bologna, Italy.

The term melanonychia describes a black-brown-gray pigmentation of the nail plate that, in most cases, appears as a longitudinal band. Melanonychia can be observed at any age, affecting one digit or several digits, in both fingernails and toenails. Its causes can be difficult to differentiate clinically and depend on the number of bands and on their color, edge, and width. Read More

J Am Acad Dermatol 2019 May 11;80(5):1272-1283. Epub 2019 Feb 11.

Department of Dermatology, Weill Cornell Medicine, New York, New York. Electronic address:

Background: Longitudinal melanonychia (LM) is a common finding in clinical practice; however, it has a broad differential diagnosis, including subungual melanoma (SUM), which can be difficult to distinguish clinically from benign conditions.

Objective: To identify clinical and dermoscopic features that distinguish histopathologically diagnosed SUM from benign LM and to evaluate the validity of the ABCDEF criteria among patients on whom a biopsy was performed.

Methods: Retrospective cohort study of consecutive patients who underwent nail matrix biopsy for LM at a single center from January 2011 to November 2017. Read More

Skin Appendage Disord 2018 Nov 3;5(1):20-26. Epub 2018 Jul 3.

Department of Dermatology, University of São Paulo, São Paulo, Brazil.

Background: Nail apparatus melanoma (NAM) is rare. The higher mortality reported in the literature is most likely due to advanced disease associated with delayed diagnosis and treatment.

Objective: All patients diagnosed with NAM were followed at a single reference center during a period of 10 years, with emphasis on dermatological and histological findings. Read More