1,256 results match your criteria Melanoma Iris


[Clinico-echographic diagnostics of iris tumors].

Ophthalmologe 2019 Feb 18. Epub 2019 Feb 18.

Zentrum für Augenheilkunde, Uniklinik Köln, Kerpener Str. 62, 50924, Köln, Deutschland.

Background: The differentiation of iridic space-occupying lesions represents a regularly reoccurring diagnostic challenge.

Objective: This article presents an overview of the epidemiological data and describes the diagnostic procedure for iris tumors.

Material And Methods: The article provides a review of the literature from PubMed and own clinical results. Read More

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http://dx.doi.org/10.1007/s00347-019-0861-yDOI Listing
February 2019

Very late recurrence of iris melanoma: 45 years after treatment.

Melanoma Res 2019 Feb 5. Epub 2019 Feb 5.

Ocular Oncology Service, Moorfields Eye Hospital NHS Foundation Trust.

Iris melanoma is a rare tumour that accounts for ∼3-4% of all uveal melanoma cases. In the past, surgical resection was the sole treatement option, whereas nowadays, it has been replaced by brachytherapy as treatment of choice. Surgical resection is still in use in selected cases but combined with adjuvant radiotherapy in cases of incomplete resection. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000581DOI Listing
February 2019
2.282 Impact Factor

History of melanoma in situ · dyspnea · rib pain · Dx?

J Fam Pract 2019 Jan/Feb;68(1):E20-E23

Division of Pulmonary Medicine,Department of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.

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February 2019

Outcomes of Glaucoma Drainage Device Surgery in Eyes with Treated Uveal Melanoma.

Ocul Oncol Pathol 2019 Jan 2;5(1):20-27. Epub 2018 May 2.

Stein Eye and Doheny Eye Institutes, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Aim: We report patient safety and intraocular pressure (IOP) control after placement of a glaucoma drainage device (GDD) in eyes with a history of treated malignant uveal melanoma.

Methods: A retrospective review of the records of patients with uveal melanoma was performed. Outcomes were local tumor recurrence, rate of metastases, and to-nometric success, based on survival curves, defined as IOP < 21 mm Hg. Read More

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https://www.karger.com/Article/FullText/488056
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http://dx.doi.org/10.1159/000488056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341335PMC
January 2019
4 Reads

[New molecular pathological strategies for malignant iris tumors].

Ophthalmologe 2019 Jan 8. Epub 2019 Jan 8.

Zentrum für Augenheilkunde, Universitätsklinikum zu Köln, Köln, Deutschland.

Background: Molecular pathological research offers new chances for the diagnostic and therapeutic management of malignant iris tumors. Besides immunohistological and polymerase chain reaction analyses further techniques, such as multiplex ligation-dependent probe amplification, microsatellite analyses and next-generation sequencing are able to detect various mutations in the tumor genome.

Objective: An up to date review of new molecular pathological strategies for malignant iris tumors was carried out. Read More

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http://link.springer.com/10.1007/s00347-018-0840-8
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http://dx.doi.org/10.1007/s00347-018-0840-8DOI Listing
January 2019
6 Reads

Iris melanoma relapsing sixteen years after proton-beam therapy: The importance of lifelong follow-up.

Am J Ophthalmol Case Rep 2019 Mar 6;13:89-92. Epub 2018 Dec 6.

Institut Curie, PSL Research University, Department of Ophthalmology, F-75005, Paris, France.

Purpose: To report a case of locally recurrent spindle-cell iris amelanotic melanoma 16 years after proton-beam therapy.

Observations: In 2001, a 45-year-old man presented with an amelanotic iris melanoma, extending from the 5 to 10 o'clock positions on his left eye. High-frequency ultrasonography showed extension of melanoma into the ciliary body. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305799PMC

Basal cell carcinomas developing independently from BAP1-tumor predisposition syndrome in a patient with bilateral uveal melanoma: Diagnostic challenges to identify patients with BAP1-TPDS.

Genes Chromosomes Cancer 2018 Dec 22. Epub 2018 Dec 22.

Department of Ophthalmology, Division of Ophthalmic Pathology, University Hospital Bonn, Bonn, Germany.

Basal cell carcinomas (BCC) have been recently included into the spectrum of BAP1-tumor predisposition syndrome (TPDS). Uveal melanoma (UM) is also a tumor often observed in patients with this hereditary tumor syndrome, in particular bilateral UM is highly suspicious for BAP1-TPDS although no patient has been reported yet. Based on our index patient with BAP1-TPDS with bilateral UM (choroid OD, oculus dexter; iris OS, oculus sinister), several BCCs and thyroid cancer as well as a family history for cancer, this paper analyzes hints and pitfalls to diagnose this syndrome clinically and histologically. Read More

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http://dx.doi.org/10.1002/gcc.22724DOI Listing
December 2018

Glaucoma secondary to intraocular tumors: mechanisms and management.

Curr Opin Ophthalmol 2019 Mar;30(2):71-81

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose Of Review: Glaucoma secondary to intraocular tumors is important to consider in eyes with a known tumor and those with unilateral or refractory glaucoma. The purpose of this review is to discuss the mechanisms and management of intraocular tumors with related secondary glaucoma.

Recent Findings: Several intraocular tumors can lead to glaucoma, including iris melanoma, iris metastasis, iris lymphoma, trabecular meshwork melanoma, choroidal melanoma, choroidal metastasis, retinoblastoma, and medulloepithelioma. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000550DOI Listing
March 2019
7 Reads

Melanoma tumour vasculature heterogeneity: from mice models to human.

J Cancer Res Clin Oncol 2019 Mar 13;145(3):589-597. Epub 2018 Dec 13.

UMR Inserm 1066, CNRS 6021, Université d'Angers, CHU, IBS, IRIS, MINT, UNIV Angers, INSERM, CNRS, Université Bretagne Loire, IBS-CHU, 4, rue Larrey, 49933, Angers, France.

Tumour angiogenesis is defined by an anarchic vasculature and irregularities in alignment of endothelial cells. These structural abnormalities could explain the variability in distribution of nanomedicines in various tumour models. Then, the main goal of this study was to compare and to characterize the tumour vascular structure in different mouse models of melanoma tumours (B16F10 and SK-Mel-28) and in human melanomas from different patients. Read More

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http://link.springer.com/10.1007/s00432-018-2809-z
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http://dx.doi.org/10.1007/s00432-018-2809-zDOI Listing
March 2019
13 Reads
3.081 Impact Factor

[New treatment options for iridociliary tumors].

Ophthalmologe 2018 Dec 4. Epub 2018 Dec 4.

Zentrum für Augenheilkunde, Universität zu Köln, Kerpener Str. 62, 50924, Köln, Deutschland.

Background: Benign iridal tumors rarely necessitate a therapeutic intervention. In contrast, malignant tumors of the iris can threaten the patient's life and eyesight and require early treatment to prevent the development of metastases.

Objective: Presentation of current treatment options for iridal tumors with special emphasis on iridal melanoma. Read More

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http://dx.doi.org/10.1007/s00347-018-0825-7DOI Listing
December 2018
3 Reads

Amelanotic iris melanoma in a 7 year-old hispanic boy with subclinical globe perforation.

Arch Soc Esp Oftalmol 2019 Feb 17;94(2):81-84. Epub 2018 Oct 17.

Unidad de Oftalmología Pediátrica, Estrabismo y Neuro-Oftalmología «Dra. Ana María Illescas Putzeys», Benemérito Comité Pro Ciegos y Sordos de Guatemala, Hospital de Ojos y Oídos «Dr. Rodolfo Robles Valverde», Instituto de Ciencias de la Visión, Ciudad Guatemala, Guatemala.

We report an unusual case of an amelanotic melanoma in a 7 year old hispanic child with subclinical globe perforation. Uveal melanoma rarely occurs in children. Young affected patients are mostly light-colored eye Caucasian adolescents. Read More

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http://dx.doi.org/10.1016/j.oftal.2018.09.007DOI Listing
February 2019
1 Read

Melanoma or glaucoma? A case report.

Arch Soc Esp Oftalmol 2018 Dec 27;93(12):610-612. Epub 2018 Sep 27.

Sección de Glaucoma, FISABIO Oftalmología Médica, Valencia, España.

Case Report: The case is presented of a patient referred to us with suspicion of a ciliary body melanoma due to a pigmented lesion in iris root of left eye, associated with high intraocular pressure, despite maximal topical and systemic medication. The systematic workup revealed unilateral changes in the corneal endothelium, compatible with an iridocorneal syndrome. An Ahmed valve was inserted, achieving sustained control of intraocular pressure and visual field defects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03656691183018
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http://dx.doi.org/10.1016/j.oftal.2018.06.002DOI Listing
December 2018
1 Read

Case Report: Importance of B-scan Ultrasonography for the Detection of Choroidal Melanoma.

Optom Vis Sci 2018 Oct;95(10):971-974

Murray Ocular Oncology and Retina, Miami, Florida

Significance: This case highlights the importance of using ultrasonography to evaluate an eye that has no clear view of the fundus.

Purpose: Uveal melanoma stems from melanocytes found in the iris, ciliary body, and choroid, and it is the most common primary intraocular malignancy found in adults. The lesion is identified predominantly via fundus biomicroscopy and binocular indirect ophthalmoscopy. Read More

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http://dx.doi.org/10.1097/OPX.0000000000001287DOI Listing
October 2018
2 Reads

Monte Carlo dosimetry modeling of focused kV x-ray radiotherapy of eye diseases with potential nanoparticle dose enhancement.

Med Phys 2018 Oct 21;45(10):4720-4733. Epub 2018 Sep 21.

Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, 06510, USA.

Purpose: Eye plaque brachytherapy is the most common approach for intraocular cancer treatment. It is, however, invasive and subject to large setup uncertainty due to the surgical operation. We propose a novel-focused kV x-ray technique with potential nanoparticle (NP) enhancement and evaluate its application in treating choroidal melanoma and iris melanoma by Monte Carlo (MC) dosimetry modeling. Read More

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http://dx.doi.org/10.1002/mp.13144DOI Listing
October 2018
16 Reads

Iris Melanoma in a Child Simulating Juvenile Xanthogranuloma.

Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):115-117

Department of Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

An 8-year-old girl was referred for an amelanotic iris tumor believed to have enlarged slightly over 3 months, suspicious for juvenile xanthogranuloma (JXG). The affected right eye had a lightly pigmented, vascular iris mass measuring 6 mm in basal dimension and 2 mm in thickness. There were no feeder vessels, seeding, inflammatory cells, or cutaneous abnormalities. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_7_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071340PMC
September 2018
1 Read

Uveal Metastasis: Clinical Features and Survival Outcome of 2214 Tumors in 1111 Patients Based on Primary Tumor Origin.

Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):81-90

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: The purpose of this study is to evaluate patients with uveal metastasis based on primary tumor site.

Methods: Retrospective analysis from Wills Eye Hospital, Philadelphia, PA, USA, for uveal metastasis clinical features and outcomes based on the primary tumor site.

Results: There were 2214 uveal metastases diagnosed in 1111 consecutive patients. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_6_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071342PMC
September 2018
7 Reads

Near-infrared and short-wave autofluorescence in ocular specimens.

Jpn J Ophthalmol 2018 Sep 2;62(5):605-613. Epub 2018 Aug 2.

Department of Ophthalmology, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima City, Fukushima, 960-1295, Japan.

Purpose: To determine histopathologic characteristics of near-infrared autofluorescence (NIR-AF) and short-wave autofluorescence (SW-AF) in ocular tissue.

Study Design: Retrospective study.

Methods: Unstained specimens from four enucleated eyes with uveal melanoma were prepared for evaluation by fluorescence microscopy. Read More

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http://link.springer.com/10.1007/s10384-018-0614-5
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http://dx.doi.org/10.1007/s10384-018-0614-5DOI Listing
September 2018
7 Reads

Iris melanoma presenting as childhood glaucoma.

Am J Ophthalmol Case Rep 2018 Sep 26;11:56-60. Epub 2018 May 26.

Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, SC, USA.

Purpose: To describe the natural history and management of a rare case of iris melanoma in a pediatric patient.

Observations: A Caucasian female presented with left pupillary abnormalities at age 7, progressive iris changes at age 9, and markedly elevated intraocular pressure with advanced optic nerve cupping at 11 years of age. She was found to have a pigmented lesion overlying her iris and invading her angle. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047055PMC
September 2018
4 Reads

Distinguishing midzonal iris pigment epithelial cyst from adenoma and ciliary body melanoma.

Oman J Ophthalmol 2018 May-Aug;11(2):161-163

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

A 49-year old male with corrected visual acuity of 20/25 OD and 20/20 OS was found to have an asymptomatic dark iris mass OD with suspicion for ciliary body melanoma. Predilation slit-lamp biomicroscopy revealed a well-circumscribed brown round mass arising posterior to the iris, presumably from the ciliary body; however, postdilation demonstrated an extended fusiform mass of the iris pigment epithelium (IPE). By anterior segment imaging, the well-circumscribed IPE mass was cystic and measured 1440 microns in thickness peripherally predilation and 300 microns in thickness postdilation. Read More

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http://dx.doi.org/10.4103/ojo.OJO_226_2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991049PMC
June 2018
1 Read

Enhanced melanoma diagnosis with multispectral digital skin lesion analysis.

Cutis 2018 May;101(5):338-340

Department of Dermatology, New York University School of Medicine, New York, USA.

Multispectral digital skin lesion analysis (MSDSLA) is both sensitive and specific in the detection of malignant melanoma by dermatologists and nondermatologists, and data have shown that MSDSLA can be a valuable tool in the evaluation of pigmented skin lesions (PSLs). This study aimed to aggregate data from 7 prior studies to provide a comprehensive overview and evaluate the consistency of the effects of MSDSLA when used in conjunction with clinical examination and dermoscopy to evaluate PSLs. Read More

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May 2018
2 Reads

Clinical and pathological correlation of cotton wool spots in secondary angle closure glaucoma.

Am J Ophthalmol Case Rep 2018 Jun 28;10:192-195. Epub 2018 Feb 28.

University of California, Gavin Herbert Eye Institute, Irvine, CA, USA.

Purpose: Cotton Wool Spots (CWS) are a commonly described retinal finding in the posterior segment associated with an extensive number of systemic diseases. The appearance of a CWS in the setting of glaucoma has rarely been reported and has not been correlated with pathology to localized loss of the nerve fiber layer previously. In this case report, we augment a previous report of an 18 year old female with a diagnosis of low grade ciliary body melanoma. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.02.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956715PMC
June 2018
19 Reads

Lack of tumour pigmentation in conjunctival melanoma is associated with light iris colour and worse prognosis.

Br J Ophthalmol 2018 May 18. Epub 2018 May 18.

Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands

Aim: To investigate whether differences in iris colour, skin colour and tumour pigmentation are related to clinical outcome in conjunctival melanoma.

Methods: Data of 70 patients with conjunctival melanoma from the Leiden University Medical Center (Leiden, The Netherlands) and 374 patients from the Wills Eye Hospital (Philadephia, USA) were reviewed. The relation between iris colour, skin colour and tumour pigmentation versus clinical parameters and outcome was investigated using univariate and multivariate regression analyses. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312018DOI Listing
May 2018
4 Reads

Advanced Midzonal Iris Pigment Epithelial Cyst Managed by Aspiration Deflation.

Ocul Oncol Pathol 2018 Apr 9;4(3):182-185. Epub 2017 Nov 9.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

Background: There are several cysts that can occur in the iris. The midzonal (retroiridic) iris pigment epithelial (IPE) cyst is important because it can simulate melanoma of the ciliary body. However, it is frequently asymptomatic and requires no treatment. Read More

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http://dx.doi.org/10.1159/000481405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939718PMC
April 2018
1 Read

Uveal Melanoma: 5-Year Update on Incidence, Treatment, and Survival (SEER 1973-2013).

Ocul Oncol Pathol 2018 Apr 13;4(3):145-151. Epub 2017 Oct 13.

Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.

Purpose: To analyze trends in incidence, treatment, and survival of uveal melanoma in the United States from 1973 to 2013 using the Surveillance, Epidemiology, and End Results database.

Materials And Methods: Patients were identified using International Classification of Disease for Oncology codes: C69.3 (choroid), C69. Read More

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http://dx.doi.org/10.1159/000480640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939716PMC
April 2018
1 Read

[Nevus or Melanoma of the Iris? A Progressive Course Over at Least 43 Years].

Klin Monbl Augenheilkd 2018 May 3. Epub 2018 May 3.

Universitäts-Augenklinik, Eberhard-Karls-Universität Tübingen.

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http://dx.doi.org/10.1055/a-0599-1076DOI Listing

Immune privilege: failure of immunotherapy in controlling metastatic cutaneous melanoma to the eye.

Melanoma Res 2018 08;28(4):359-362

Moorfields Eye Hospital.

This report concerns a 49-year-old female with cutaneous malignant melanoma and systemic metastases. These resolved following combination immunotherapy with ipilimumab and nivolumab. She subsequently experienced unilateral floaters, an increase in iris pigmentation and pigmentary glaucoma. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000443DOI Listing
August 2018
9 Reads
2.282 Impact Factor

Uveal Melanoma Associated With Myotonic Dystrophy: A Report of 6 Cases.

JAMA Ophthalmol 2018 May;136(5):543-547

The Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Importance: Patients with myotonic dystrophy (MD) have an increased risk of malignancy including uveal melanoma. This case series further explores the association between these 2 diseases.

Objective: To describe a cohort of patients with uveal melanoma associated with MD, including a case of iris melanoma, and MD-associated uveal melanoma in relatives. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2018.0554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876914PMC
May 2018
2 Reads

Retraction: Brachytherapy and anterior segment imaging in iris melanoma.

Authors:

Oman J Ophthalmol 2018 Jan-Apr;11(1):100

[This retracts the article on p. 114 in vol. 10, PMID: 28757700. Read More

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http://dx.doi.org/10.4103/0974-620X.226329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848339PMC

Circulating cell-free DNA does not harbour a diagnostic benefit in cats with feline diffuse iris melanomas.

J Feline Med Surg 2019 Feb 13;21(2):124-132. Epub 2018 Mar 13.

1 Department for Companion Animals and Horses, Vetmeduni Vienna, Vienna, Austria.

Objectives: Feline diffuse iris melanoma (FDIM) is the most common malignant primary intraocular tumour in cats, with reported metastases rates between 19% and 63%. Currently, the only available diagnostic tool for a tentative diagnosis is histopathological examination of the enucleated eye. Therefore, the veterinary ophthalmologist is often faced with the dilemma of whether to enucleate an oftentimes visual eye or to continue monitoring, with the risk of metastases developing. Read More

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http://dx.doi.org/10.1177/1098612X18762017DOI Listing
February 2019
2 Reads

The iris signal: blue periphery, tan collaret and freckles pattern - strong indicators for epidermal skin cancer in South-Eastern Europe.

J Eur Acad Dermatol Venereol 2018 Oct 30;32(10):1662-1667. Epub 2018 Mar 30.

Department of Dermatology, 'Carol Davila' University of Medicine and Pharmacy, Colentina Hospital, Bucharest, Romania.

Background: Eye and skin share the embryological origin. Both are established risk factors in epidermal skin cancer. There are few reports using iris colour classification scales, most of them analyse colour in general or are too complex to use in daily practice. Read More

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http://dx.doi.org/10.1111/jdv.14929DOI Listing
October 2018
4 Reads

The Oncolytic Virus VSV-GP Is Effective against Malignant Melanoma.

Viruses 2018 03 2;10(3). Epub 2018 Mar 2.

Division of Virology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Previously, we described VSV-GP, a modified version of the vesicular stomatitis virus, as a non-neurotoxic oncolytic virus that is effective for the treatment of malignant glioblastoma and ovarian cancer. Here, we evaluate the therapeutic efficacy of VSV-GP for malignant melanoma. All of the human, mouse, and canine melanoma cell lines that were tested, alongside most primary human melanoma cultures, were infected by VSV-GP and efficiently killed. Read More

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http://dx.doi.org/10.3390/v10030108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869501PMC
March 2018
4 Reads

Optical coherence tomography angiography of a pigmented Fuchs' adenoma (age-related hyperplasia of the nonpigmented ciliary body epithelium) masquerading as a ciliary body melanoma.

Am J Ophthalmol Case Rep 2018 Mar 10;9:72-74. Epub 2018 Jan 10.

Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA.

Purpose: To report a case of age-related hypertrophy of the nonpigmented ciliary epithelium (ARH-NPCE) clinically resembling a ciliary body melanoma and report the optical coherence tomography angiography (OCTA) findings associated with this lesion.

Observations: A 51-year-old male was referred for evaluation of a deeply pigmented ciliary body mass with extension through the iris root. Iridocyclectomy was performed due to concern for ciliary body melanoma. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786886PMC
March 2018
10 Reads

Salvage proton beam therapy for recurrent iris melanoma: outcome and side effects.

Graefes Arch Clin Exp Ophthalmol 2018 Jul 20;256(7):1325-1332. Epub 2018 Feb 20.

Augenklinik/Department of Ophthalmology, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.

Purpose: This study aims to analyze the effect of salvage proton beam therapy for the treatment of recurrent iris melanoma.

Method: In this clinical case series, we retrospectively analyzed the data of eight patients who underwent proton beam therapy of the whole anterior segment as salvage therapy between 2000 and 2016 for recurrent iris melanoma after resection, ruthenium brachytherapy, or sector proton beam therapy. Two patients received salvage proton beam therapy for repeated tumor relapse. Read More

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http://dx.doi.org/10.1007/s00417-018-3929-5DOI Listing
July 2018
1 Read

Secondary Glaucoma due to Iridescent Crystalline Particles Masquerading as Refractory Hypertensive Uveitis in an Eye With Irradiated Iris Melanoma.

J Glaucoma 2018 Apr;27(4):385-388

Department of Ophthalmology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry.

Purpose: We report a previously unrecognized mechanism of secondary glaucoma due to iridescent crystalline particles released from an irradiated iris melanoma. It masqueraded as refractory hypertensive uveitis following uncomplicated phacoemulsification.

Materials And Methods: A 58-year-old gentleman had an iris melanoma that underwent successful regression following irradiation with proton beam radiotherapy. Read More

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http://dx.doi.org/10.1097/IJG.0000000000000891DOI Listing
April 2018
3 Reads

Fast growing melanoma following treatment with vismodegib for locally advanced basal cell carcinomas: report of two cases.

Eur J Cancer 2018 03 16;91:177-179. Epub 2018 Jan 16.

Dermatology Clinic, Hospital Maggiore, University of Trieste, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.11.031DOI Listing
March 2018
8 Reads

Genetic Background of Iris Melanomas and Iris Melanocytic Tumors of Uncertain Malignant Potential.

Ophthalmology 2018 Jun 19;125(6):904-912. Epub 2018 Jan 19.

Department of Ocular Oncology, The Rotterdam Eye Hospital, Rotterdam, The Netherlands; Department of Pathology, Section Ophthalmic Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address:

Purpose: Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Iris melanoma comprises 4% to 10% of all UMs and has a lower mortality rate. The genetic changes in iris melanoma are not as well characterized as ciliary body or choroidal melanoma. Read More

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http://dx.doi.org/10.1016/j.ophtha.2017.12.022DOI Listing
June 2018
9 Reads

Retinoinvasive Uveal Melanoma: Report of 2 Cases and Review of the Literature.

Ocul Oncol Pathol 2017 Nov 14;3(4):292-295. Epub 2017 Apr 14.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.

Purpose: To describe the clinical history and histopathologic findings of 2 cases of retinoinvasive uveal melanoma.

Methods: The medical records and pathology specimens of 2 patients with retinoinvasive uveal melanoma were reviewed.

Results: The first patient had an iris/ciliary body melanoma that was treated and the second patient had suspected iridocorneal endothelial syndrome. Read More

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http://dx.doi.org/10.1159/000468940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757583PMC
November 2017
5 Reads

The Impact of Quantitative Data Provided by a Multi-spectral Digital Skin Lesion Analysis Device on Dermatologists'Decisions to Biopsy Pigmented Lesions.

J Clin Aesthet Dermatol 2017 Sep 1;10(9):24-26. Epub 2017 Sep 1.

Dr. Farberg is with the Icahn School of Medicine, Dermatology, at Mount Sinai in New York, New York.

Early diagnosis of melanoma is critical to survival. New technologies, such as a multi-spectral digital skin lesion analysis (MSDSLA) device [MelaFind, STRATA Skin Sciences, Horsham, Pennsylvania] may be useful to enhance clinician evaluation of concerning pigmented skin lesions. Previous studies evaluated the effect of only the binary output. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749615PMC
September 2017
8 Reads

Iris Melanoma Outcomes Based on the American Joint Committee on Cancer Classification (Eighth Edition) in 432 Patients.

Ophthalmology 2018 Jun 17;125(6):913-923. Epub 2018 Jan 17.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose: The American Joint Committee on Cancer (AJCC) classification was updated to the eighth edition in January 2017, providing staging for iris melanoma. This study evaluated outcomes of iris melanoma per the AJCC classification, eighth edition.

Design: Retrospective case series. Read More

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http://dx.doi.org/10.1016/j.ophtha.2017.11.040DOI Listing
June 2018
4 Reads

Iris pigmented lesions as a marker of cutaneous melanoma risk: an Australian case-control study.

Br J Dermatol 2018 May 6;178(5):1119-1127. Epub 2018 Apr 6.

Dermatology Research Centre, The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Brisbane, 4102, Australia.

Background: Iris naevi and iris freckles have a frequency of 4% and 50% in the European population, respectively. They are associated with dysplastic naevi, but few studies have examined their link to cutaneous melanoma.

Objectives: To assess whether iris pigmented lesions are a predictive indicator for cutaneous melanoma. Read More

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http://dx.doi.org/10.1111/bjd.16323DOI Listing
May 2018
38 Reads

Cyclooxygenase-2 expression in the eyes of cats with and without uveitis.

Am J Vet Res 2018 Jan;79(1):90-97

OBJECTIVE To characterize the distribution and intensity of cyclooxygenase (COX)-2 expression in the eyes of cats with and without uveitis and to determine whether COX-2 expression is correlated with severity of inflammation. SAMPLES Archived ocular tissue specimens from 51 cats with and 10 cats without ocular disease. PROCEDURES Specimens from only 1 eye were evaluated for each cat. Read More

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http://dx.doi.org/10.2460/ajvr.79.1.90DOI Listing
January 2018
4 Reads

Young Woman With Eye Pressure.

Ann Emerg Med 2017 Dec;70(6):e53-e54

Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1016/j.annemergmed.2017.06.037DOI Listing
December 2017
2 Reads

[Diagnosis and Therapy of Iris Lesions].

Klin Monbl Augenheilkd 2017 Dec 20;234(12):1541-1554. Epub 2017 Nov 20.

The most common iris lesions are iris nevi, iris melanomas and iris pigment epithelium cysts. However, there is an abundance of rare differential diagnoses that have to be considered, including other melanocytic and non-melanocytic lesions. Diagnostic tools include the slit lamp examination, gonioscopy, tonometry, transillumination, ultrasound biomicroscopy (UBM), optical coherence tomography, fluorescein angiography and standardized photography-assisted documentation. Read More

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http://dx.doi.org/10.1055/s-0043-120093DOI Listing
December 2017
6 Reads

Limbal Stem Cell Preservation During Proton Beam Irradiation for Diffuse Iris Melanoma.

Cornea 2018 02;37(2):e6

Strahlenklinik, University Hospital Essen, Essen, Germany.

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http://dx.doi.org/10.1097/ICO.0000000000001457DOI Listing
February 2018
4 Reads

Proton Beam Therapy for Iris Melanomas in 107 Patients.

Ophthalmology 2018 Apr 8;125(4):606-614. Epub 2017 Nov 8.

Department of Ophthalmology, University Hospital Pasteur 2, Nice, France.

Purpose: To report on the clinical characteristics and outcomes for patients with iris melanoma using proton therapy.

Design: Retrospective study.

Participants: One hundred seven patients with iris melanoma from 3 regional ophthalmologic centers. Read More

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http://dx.doi.org/10.1016/j.ophtha.2017.10.009DOI Listing
April 2018
11 Reads

Ruthenium-106 brachytherapy for iris and iridociliary melanomas.

Br J Ophthalmol 2018 Aug 9;102(8):1154-1159. Epub 2017 Nov 9.

Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands.

Background And Purpose: To evaluate ruthenium-106 (Ru106) brachytherapy as eye-conserving treatment of iris melanomas (IMs) and iridociliary melanomas (ICMs).

Materials And Methods: Eighty-eight patients received Ru106 brachytherapy between 2006 and 2016. Primary outcome was local control, and secondary outcomes were metastasis, survival, eye preservation, complications and visual acuity (VA). Read More

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http://dx.doi.org/10.1136/bjophthalmol-2017-310688DOI Listing
August 2018
5 Reads

Human iris three-dimensional imaging at micron resolution by a micro-plenoptic camera.

Biomed Opt Express 2017 Oct 14;8(10):4514-4522. Epub 2017 Sep 14.

Department of Mechanical Engineering, University of Michigan, 1231 Beal Avenue, Ann Arbor, MI 48109, USA.

A micro-plenoptic system was designed to capture the three-dimensional (3D) topography of the anterior iris surface by simple single-shot imaging. Within a depth-of-field of 2.4 mm, depth resolution of 10 µm can be achieved with accuracy (systematic errors) and precision (random errors) below 20%. Read More

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http://dx.doi.org/10.1364/BOE.8.004514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654796PMC
October 2017
2 Reads

Handheld Photoacoustic Microscopy Probe.

Sci Rep 2017 Oct 17;7(1):13359. Epub 2017 Oct 17.

School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, Republic of Korea.

Optical resolution photoacoustic microscopy (OR-PAM) is a non-invasive, label-free method of in vivo imaging with microscopic resolution and high optical contrast. Based on intrinsic contrasts, OR-PAM has expanded to include in vivo vessel imaging, flow cytometry, physiological parameter analysis, and single-cell characterization. However, since conventional OR-PAM systems have a fixed tabletop configuration, a large system size, and slow imaging speed, their use in preclinical and clinical studies remains limited. Read More

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http://dx.doi.org/10.1038/s41598-017-13224-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645466PMC
October 2017
5 Reads

[Ocular melanomas : An update].

Pathologe 2017 Nov;38(6):491-499

Liverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, Großbritannien.

Melanoma is the most common type of primary cancer to affect the adult eye. Approximately 95% of ocular melanomas are intraocular and arise from the uvea (i. e. Read More

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http://dx.doi.org/10.1007/s00292-017-0389-3DOI Listing
November 2017
2 Reads