1,309 results match your criteria Melanoma Iris


Posterior uveal melanoma in 321 Asian Indian patients: analysis based on the 8th edition of American Joint Committee Cancer classification.

Int Ophthalmol 2020 Jun 29. Epub 2020 Jun 29.

Ophthalmic Biophysics, L V Prasad Eye Institute, Hyderabad, India.

Purpose: To evaluate the presenting features, treatment, and outcomes of posterior uveal melanoma (PUM) in Asian Indians based on the 8th edition of American Joint Committee on Cancer (AJCC) classification.

Methods: Retrospective interventional case series of 321 Asian Indian patients with PUM.

Results: Based on AJCC, PUM was classified into categories T1 (n = 36; 11%), T2 (n = 74; 23%), T3 (n = 126; 39%), and T4 (n = 85; 27%). Read More

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http://dx.doi.org/10.1007/s10792-020-01494-2DOI Listing

Optic nerve invasion of non-juxtapapillary uveal melanoma: a rare occurrence.

BMJ Case Rep 2020 Jun 28;13(6). Epub 2020 Jun 28.

Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, India

A 44-year-old man presented with complaints of pain and discomfort in his left eye (OS). On examination, he had bare perception of light in OS and had a diffuse pigmented mass lesion in the nasal quadrant of the bulbar conjunctiva, associated with neovascularisation of the iris and iridocyclitis, with no fundus view. Intraocular pressure OS was 40 mm Hg. Read More

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http://dx.doi.org/10.1136/bcr-2020-234610DOI Listing

Iris Vascular Malformation with 360-Degree Iridocorneal Angle Affectation.

Case Rep Ophthalmol Med 2020 2;2020:5913636. Epub 2020 Jun 2.

Ophthalmology Department, 12 de Octubre Hospital, Complutense University, 28041 Madrid, Spain.

Vascular iris lesions are rare and can sometimes be associated to systemic vascular lesions. They usually cause spontaneous recurrent hyphema. The differential diagnosis should be considered primarily with iris rubeosis and with highly vascular tumors as iris melanoma. Read More

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http://dx.doi.org/10.1155/2020/5913636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288034PMC

Optic Disc Pit Maculopathy - Case Series, Clinical Approach, and Management.

Middle East Afr J Ophthalmol 2020 Jan-Mar;27(1):34-39. Epub 2020 Apr 29.

Department of Ophthalmology, Birmingham and Midland Eye Centre, Birmingham, England, United Kingdom.

Purpose: The purpose of this study was to analyze the diagnostic and therapeutic approach of five cases with optic disc pit (ODP) maculopathy.

Materials And Methods: This was a retrospective study of five patients diagnosed with ODP maculopathy. Four of these cases had unilateral involvement, whereas one case had bilateral findings. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_181_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276172PMC

Side effects of proton beam therapy of choroidal melanoma in dependence of the dose to the optic disc and the irradiated length of the optic nerve.

Graefes Arch Clin Exp Ophthalmol 2020 Jun 12. Epub 2020 Jun 12.

Department of Radiation Oncology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Purpose: To analyze the impact of the dose to the optic disc and the irradiated length of the optic nerve on radiation-induced optic neuropathy, radiation-induced retinopathy, iris neovascularization, secondary glaucoma, enucleation, and local tumor control after proton beam therapy (PBT) of choroidal melanoma.

Method: Retrospective analysis of 1129 patients, who received primary PBT for the treatment of choroidal melanoma with a dose of 60 cobalt gray equivalents (CGE) between 1998 and 2013 at the Helmholtz-Zentrum Berlin, Germany. Kaplan-Meier curves and logrank test have been used for time-to-event analyses. Read More

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http://dx.doi.org/10.1007/s00417-020-04780-yDOI Listing

Uveal Melanoma in an Aradi Goat (Capra aegagrus hircus).

J Comp Pathol 2020 May 22;177:5-9. Epub 2020 Apr 22.

Department of Pathology, Faculty of Veterinary Medicine, Mansoura University, Dakahlia, Egypt. Electronic address:

A 6-year-old Aradi goat (Capra aegagrus hircus) was admitted with glaucoma of the left eye. Blood clots and a yellow exudate covered the cornea and sclera. Ocular examination found glaucoma, exophthalmos and a distorted iris. Read More

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http://dx.doi.org/10.1016/j.jcpa.2020.03.006DOI Listing

The MOLES System for Planning Management of Melanocytic Choroidal Tumors: Is It Safe?

Cancers (Basel) 2020 May 21;12(5). Epub 2020 May 21.

Ocular Oncology Service, Moorfields Eye Hospital, London EC1V 2PD, UK.

Purpose: To evaluate the MOLES system for identifying malignancy in melanocytic choroidal tumors in patients treated for choroidal melanoma.

Methods: Records of 615 patients treated for choroidal melanoma between January 2017 and December 2019 were reviewed. Patients were excluded if iris and/or ciliary body involvement (106 patients), inadequate fundus photography (26 patients), no images available for review (21 patients) and/or treatment was not primary (11 patients). Read More

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http://dx.doi.org/10.3390/cancers12051311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281649PMC

Molecular profiling of vitreous fluid by massively parallel sequencing: a case series.

J Am Soc Cytopathol 2020 Apr 13. Epub 2020 Apr 13.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina.

Introduction: In cases of suspected intraocular malignancy, vitreous may be the preferred pathologic sample; however, cellularity may be insufficient for definitive cytopathological diagnosis. Ancillary methodology to study vitreous fluid aspiration for mutational analysis may assist in treatment decisions.

Materials And Methods: Three individual patient vitreous humor samples were received in the laboratory for mutation testing. Read More

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http://dx.doi.org/10.1016/j.jasc.2020.03.005DOI Listing

Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours.

Nat Commun 2020 May 15;11(1):2408. Epub 2020 May 15.

QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

Uveal melanoma (UM) is the most common intraocular tumour in adults and despite surgical or radiation treatment of primary tumours, ~50% of patients progress to metastatic disease. Therapeutic options for metastatic UM are limited, with clinical trials having little impact. Here we perform whole-genome sequencing (WGS) of 103 UM from all sites of the uveal tract (choroid, ciliary body, iris). Read More

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http://dx.doi.org/10.1038/s41467-020-16276-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229209PMC

Palladium-103 plaque therapy for multifocal iris melanoma: Radiation of the entire anterior segment of the eye.

Eur J Ophthalmol 2020 Apr 20:1120672120914235. Epub 2020 Apr 20.

The New York Eye Cancer Center, New York, NY, USA.

Purpose: To investigate the safety and tolerability of total anterior segment palladium-103 (Pd) eye plaque brachytherapy for multifocal iris melanoma.

Methods: Interventional case series of 11 patients with multifocal iris melanomas. Anterior segment ultrasound revealed tumor size, location, and intraocular margins. Read More

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http://dx.doi.org/10.1177/1120672120914235DOI Listing

Impact of uveal melanoma thickness on post-plaque radiotherapy outcomes in the prophylactic anti-vascular endothelial growth factor era in 1131 patients.

Clin Exp Ophthalmol 2020 Apr 10. Epub 2020 Apr 10.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Importance: The impact of tumour thickness on radiation complications following plaque radiotherapy for uveal melanoma in the anti-vascular endothelial growth factor (VEGF) era remains unknown.

Background: To evaluate treatment outcomes following plaque radiotherapy and prophylactic intravitreal bevacizumab for uveal melanoma based on initial tumour thickness.

Design: This was a retrospective, interventional case series. Read More

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http://dx.doi.org/10.1111/ceo.13758DOI Listing

Glaucoma as the presenting sign of intraocular tumors: beware of the masquerading sign.

Int Ophthalmol 2020 Jul 20;40(7):1789-1795. Epub 2020 Mar 20.

Ophthalmic Plastic Surgery and Ocular Oncology Services, The Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, 500034, India.

Purpose: To discuss the clinical presentation and management of intraocular tumors masquerading as primary glaucoma or non-tumor-related secondary glaucoma.

Methods: Retrospective chart review.

Results: Ten patients with unsuspected intraocular tumor were referred to glaucoma clinic with a diagnosis of primary glaucoma or non-tumor-related secondary glaucoma. Read More

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http://dx.doi.org/10.1007/s10792-020-01348-xDOI Listing

Neurofibromatosis type 1 and melanoma of the iris arising from a dysplastic nevus: A rare yet casual association?

Eur J Ophthalmol 2020 Feb 16:1120672120906999. Epub 2020 Feb 16.

Laboratorio di Genetica Medica, Dipartimento di Scienze Biomediche e Oncologia Umana, Università degli Studi di Bari Aldo Moro, Bari, Italy.

Purpose: We investigated the molecular causes of an unusual pigmented and ulcerated iris lesion detected in a patient diagnosed with neurofibromatosis type 1 (NF1).

Case Report: A 52-year-old man was referred to our clinic with a non-traumatic ulcer in his left eye. Hyphema reabsorption disclosed a pigmented iris mass, thus ultrasound biomicroscopy and anterior segment fluorescein angiography were performed to investigate for the presence of a malignant lesion. Read More

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http://dx.doi.org/10.1177/1120672120906999DOI Listing
February 2020

Effects of plaque brachytherapy and proton beam radiotherapy on prognostic testing: a comparison of uveal melanoma genotyped by microsatellite analysis.

Br J Ophthalmol 2020 Feb 5. Epub 2020 Feb 5.

Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.

Background/aims: Proton beam radiotherapy and plaque brachytherapy are commonly applied in primary uveal melanoma (UM); however, their effect on chromosome 3 classification of UM by microsatellite analysis (MSA) for prognostication purposes is unknown, where the tumour is sampled post-irradiation. This study examined the prognostic accuracy of genotyping UM biopsied before or after administration of radiotherapy, by MSA.

Methods: 407 UM patients treated at the Liverpool Ocular Oncology Centre between January 2011 to December 2017, were genotyped for chromosome 3 by MSA; 172 and 176 primary UM were sampled prior to and post irradiation, respectively. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315363DOI Listing
February 2020

Germline Mutation Associated with Bilateral Primary Uveal Melanoma.

Ocul Oncol Pathol 2020 Jan 4;6(1):10-14. Epub 2019 Jun 4.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Purpose: To describe the occurrence of bilateral primary uveal melanoma in 2 patients with mutation on the gene encoding BRCA1-associated protein 1 .

Methods: Retrospective chart review of patients with bilateral primary uveal melanoma and subsequent positive germline mutation.

Results: There were 2 patients with bilateral uveal melanoma and germline positivity. Read More

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http://dx.doi.org/10.1159/000499570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984137PMC
January 2020

Intraocular leiomyoma: Current concepts.

Surv Ophthalmol 2020 Jul - Aug;65(4):421-437. Epub 2020 Jan 7.

The New York Eye and Ear Infirmary, Mount Sinai Hospital, New York, NY, USA.

Intraocular leiomyoma is a benign smooth muscle tumor. First recognized before the era of immunohistochemistry, uveal leiomyomas have been described in case reports and small case series. We add 3 new cases, for a total of 80. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.12.008DOI Listing
January 2020

Meta-analysis on the utility of radiotherapy for the treatment of Ocular Melanoma

Clin Ter 2020 Jan-Feb;170(1):e89-e98

Department of Sense Organs, University of Rome “Sapienza”, Rome

Introduction: Uveal melanoma is the most common intraocular tumor in the adult population. It can affect any part of the uveal tract: the iris, ciliary body, and choroid. Historically, enucleation has been the mainstay of treatment for primary melanoma. Read More

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BAP1 GERMLINE MUTATION WITH IRIDOCILIOCHOROIDAL MELANOMA AND MALIGNANT PERITONEAL MESOTHELIOMA.

Retin Cases Brief Rep 2019 Dec 31. Epub 2019 Dec 31.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose: BAP1 germline mutation can promote risk of uveal melanoma and mesothelioma. In this study, we report a patient with BAP1 germline mutation and uveal melanoma who developed a rare form of mesothelioma in the peritoneum.

Method: Case report. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000934DOI Listing
December 2019

Bleaching melanin in formalin-fixed and paraffin-embedded melanoma specimens using visible light: a pilot study.

Eur J Histochem 2019 Oct 31;63(4). Epub 2019 Oct 31.

Department of Veterinary Medicine (DIMEVET), University of Milan, Lodi.

In fluorescence microscopy, light radiation can be used to bleach fluorescent molecules in formalin-fixed and paraffin-embedded (FFPE) samples, in order to increase the ratio between signal of interest and background autofluorescence. We tested if the same principle can be exploited in bright field microscopy to bleach pigmented melanoma FFPE sections together with cell morphology maintenance. After dewaxing and rehydration, serial FFPE sections of a feline diffuse iris melanoma, a canine dermal melanoma, a gray horse dermal melanoma and a swine cutaneous melanoma were irradiated with visible light for 1, 2, 3, 4 and 5 days, prior to Hematoxylin and Eosin staining. Read More

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http://dx.doi.org/10.4081/ejh.2019.3071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829521PMC
October 2019

Diffuse Iris Melanoma: Conservative Treatment with Proton Beam Therapy after Limbal Stem Cell Preservation or Enucleation?

Ocul Oncol Pathol 2019 Oct 20;5(6):396-401. Epub 2019 Mar 20.

Département d'Ophtalmologie, Institut Curie, Paris, France.

Objectives: Iris melanomas represent 2-3% of uveal melanomas; the diffuse variant accounts for approximately 10% of all iris melanomas. Different treatment modalities for diffuse iris melanomas (DIM) have been proposed depending on the local status as well as the age and general condition of the patient.

Methods: This study is a single-centre retrospective case series describing the diagnosis, treatments and outcomes of DIM. Read More

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http://dx.doi.org/10.1159/000496847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873101PMC
October 2019

Iris biopsy to investigate feline iris hyperpigmentation.

Vet Ophthalmol 2020 Mar 16;23(2):269-276. Epub 2019 Nov 16.

Willows Veterinary Centre & Referral Service, West Midlands, UK.

Objective: To evaluate the benefit of iris biopsy in cats with iris hyperpigmentation to differentiate melanosis from early feline diffuse iris melanoma (FDIM).

Methods: The medical records of cats with unilateral iris hyperpigmentation that had undergone iris biopsy between February 2013 and September 2016 at Willows Veterinary Centre & Referral Service were reviewed.

Results: Seven cats with unilateral iris hyperpigmentation were included in this retrospective study. Read More

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http://dx.doi.org/10.1111/vop.12718DOI Listing

Glaucoma After Iodine-125 Brachytherapy for Uveal Melanoma: Incidence and Risk Factors.

J Glaucoma 2020 Jan;29(1):1-10

Stein Eye.

PRéCIS:: A single-center retrospective review over a 10-year period discovered an 8.6% risk of developing secondary open-angle glaucoma, and a 6.7% risk of neovascular glaucoma after brachytherapy for uveal melanoma. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001393DOI Listing
January 2020

Congenital choroidal melanocytoma in a child with ocular melanocytosis.

BMJ Case Rep 2019 Oct 30;12(10). Epub 2019 Oct 30.

Ocular Oncology, LV Prasad Eye Institute, Hyderabad, India

A 1-day-old child was brought to the clinic for evaluation of enlarged right eye (OD). On examination, OD showed buphthalmos with diffuse scleral melanocytosis, fleshy blackish-brown extrascleral mass with corneal extension, and secondary glaucoma. Anterior segment evaluation revealed darkly pigmented iris and fundus evaluation OD revealed a darkly pigmented choroidal lesion. Read More

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http://dx.doi.org/10.1136/bcr-2019-231376DOI Listing
October 2019

Tapioca Melanoma of the Iris: A Case Report.

J Ophthalmic Vis Res 2019 Jul-Sep;14(3):376-381. Epub 2019 Jul 18.

Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To report an extremely rare case of tapioca melanoma of the iris in an Iranian patient.

Case Report: A 50-year-old male patient presented with ocular pain and redness in the right eye for two weeks. The visual acuity was 7/10 and the intraocular pressure (IOP) was 30 mmHg. Read More

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http://dx.doi.org/10.18502/jovr.v14i3.4794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815328PMC

Choroidal melanoma, unfavorable prognostic factors. Case report and review of literature.

Rom J Morphol Embryol 2019 ;60(2):673-678

Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Romania; Department of Morphological Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Romania;

Uveal melanoma is the most common intraocular tumor characterized by increased metastatic potential. The tumor develops from uveal melanocytes that, from an embryological point of view, derive from the cells of the anterior neural crest. The risk factors associated with melanoma development are close related to patient phenotype: light-colored hair and iris, fair skin. Read More

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March 2020
1 Read

Uveal melanoma-associated survival in Scotland.

Eye (Lond) 2019 11 25;33(11):1699-1706. Epub 2019 Oct 25.

Scottish Ocular Oncology Service, Tennent Institute of Ophthalmology, Glasgow, UK.

Background/objectives: The Scottish Ocular Oncology Service (SOOS) manages all patients with uveal melanoma (UM) in Scotland. Our aim was to determine the long-term all-cause and cause-specific survival of patients with UM, irrespective of treatment modality.

Subjects/methods: A retrospective single-centre cohort study including all patients diagnosed with UM by the SOOS between 1/1/1998 and 31/12/2002. Read More

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http://dx.doi.org/10.1038/s41433-019-0622-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002729PMC
November 2019
4 Reads

Intraocular Biopsy and ImmunoMolecular Pathology for "Unmasking" Intraocular Inflammatory Diseases.

J Clin Med 2019 Oct 19;8(10). Epub 2019 Oct 19.

Vitreoretinal Department, Moorfields Eye Hospital, 162 City Rd, Old Street, London EC1V 2PD, UK.

Intraocular inflammation can hide a variety of eye pathologies. In 33% of cases, to obtain a correct diagnosis, investigation of the intraocular sample is necessary. The combined analyses of the intraocular biopsy, using immuno-pathology and molecular biology, point to resolve the diagnostic dilemmas in those cases where history, clinical tests, and ophthalmic and systemic examinations are inconclusive. Read More

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https://www.mdpi.com/2077-0383/8/10/1733
Publisher Site
http://dx.doi.org/10.3390/jcm8101733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832563PMC
October 2019
4 Reads

Genome-wide study on uveal melanoma patients finds association to DNA repair gene TDP1.

Melanoma Res 2020 04;30(2):166-172

Division of Molecular Genetic Epidemiology of German Cancer Research Center (DKFZ), Heidelberg.

Uveal melanoma is a life-threatening disease for which data on germline predisposition are essentially limited to mutations in the BAP1 gene. Many risk factors are shared between uveal melanoma and cutaneous melanoma, and these include fair skin color and light eye color. We carried out a genome-wide association study on 590 uveal melanoma patients and 5199 controls. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000641DOI Listing
April 2020
2.282 Impact Factor

Delineating the role of MITF isoforms in pigmentation and tissue homeostasis.

Pigment Cell Melanoma Res 2020 03 16;33(2):279-292. Epub 2019 Oct 16.

Department of Biological Chemistry, University of California, Irvine, CA, USA.

MITF, a gene that is mutated in familial melanoma and Waardenburg syndrome, encodes multiple isoforms expressed from alternative promoters that share common coding exons but have unique amino termini. It is not completely understood how these isoforms influence pigmentation in different tissues and how the expression of these independent isoforms of MITF is regulated. Here, we show that melanocytes express two isoforms of MITF, MITF-A and MITF-M. Read More

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http://dx.doi.org/10.1111/pcmr.12828DOI Listing
March 2020
2 Reads

The Potential Use of Electrochemotherapy in the Treatment of Uveal Melanoma: In Vitro Results in 3D Tumor Cultures and In Vivo Results in a Chick Embryo Model.

Cancers (Basel) 2019 Sep 11;11(9). Epub 2019 Sep 11.

Department of Ophthalmology, University Hospital Halle (Saale), Martin-Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120 Halle (Saale), Germany.

Uveal melanoma (UM) is the most common primary intraocular tumor that arises from neoplastic melanocytes in the choroid, iris, and ciliary body. Electrochemotherapy (ECT) has been successfully established for the treatment of skin and soft tissue metastatic lesions, deep-seated tumors of the liver, bone metastases, and unresectable pancreas lesions. The aim of this study was to evaluate the effect of ECT in vitro in 3D spheroid culture systems in primary and metastatic UM cell lines. Read More

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http://dx.doi.org/10.3390/cancers11091344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769976PMC
September 2019
2 Reads

A prospective trial of adjuvant therapy for high-risk uveal melanoma: assessing 5-year survival outcomes.

Br J Ophthalmol 2020 Apr 1;104(4):524-528. Epub 2019 Aug 1.

Department of Ophthalmic Oncology, Cleveland Clinic, Cole Eye Institute, Cleveland, Ohio, USA

Background/aims: Survival after diagnosis of metastasis from uveal melanoma is poor. Identifying individuals at high risk for metastasis and developing adjuvant therapy to prevent clinically apparent metastasis could improve survival. We conducted an adjuvant trial of sequential, low-dose dacarbazine (DTIC) and interferon-alpha-2b (IFN-α-2b) in patients with cytogenetic high-risk uveal melanoma. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-314461DOI Listing
April 2020
2 Reads

Large choroidal melanoma presenting as neovascular glaucoma.

GMS Ophthalmol Cases 2019 31;9:Doc19. Epub 2019 May 31.

Sagarmatha Choudhary Eye Hospital, Siraha, Nepal.

Choroidal melanoma is a relatively rare tumour with a poor prognosis, though it is the most common primary malignancy of the eye among adults. Choroidal melanoma has been reported to present as acute angle closure glaucoma, secondary glaucoma, chronic uveitis, cataract, and staphyloma. We report a case of a28-year-old male presenting with features of neovascular glaucoma in the right eye and having initially been treated with anti-glaucoma medications. Read More

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http://dx.doi.org/10.3205/oc000108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607447PMC
May 2019
10 Reads

Protein expression of KIT, BRAF, GNA11, GNAQ and RASSF1 in feline diffuse iris melanomas.

Vet J 2019 Jul 8;249:33-40. Epub 2019 May 8.

Department for Companion Animals and Horses, Vetmeduni Vienna, Veterinaerplatz 1, 1210 Vienna, Austria.

Feline iris melanoma, the most common feline intraocular tumour, has a reported metastatic rate of 19-63%. However, there is a lack of knowledge about its molecular biology. Previous studies have reported that feline iris melanomas do not harbour mutations comparable to common mutations found in their human counterpart. Read More

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http://dx.doi.org/10.1016/j.tvjl.2019.04.008DOI Listing
July 2019
1 Read

Intravitreal air bubble during exoresection of an iris-ciliary body melanoma.

Surg Oncol 2019 Jun 14;29:157-158. Epub 2019 May 14.

Oculoplastics-Orbit and Ocular Oncology Units, Department of Ophthalmology, Virgen Macarena University Hospital, Seville, Spain; RETICS OftaRed, Institute of Health Carlos III, Madrid, Spain. Electronic address:

In this manuscript, as members of a National Reference Unit in Ocular Oncology, we present succinctly our preferred surgical technique for iris-ciliary body melanomas. We attach a video describing the steps we usually follow [Video Clip 1], in which an impressive image of an intravitreal air bubble through the hyaloid membrane can be observed [Fig. 1]. Read More

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http://dx.doi.org/10.1016/j.suronc.2019.05.008DOI Listing
June 2019
7 Reads

Tectonic Keratoplasty to Restore the Bulbar Wall after Block Excision of Benign and Malignant Intraocular Tumors.

J Ophthalmol 2019 2;2019:4153064. Epub 2019 May 2.

Department of Ophthalmology, "Misericordia" Hospital, Grosseto, Italy.

Purpose: To report the surgical treatment and follow-up of tumors of the anterior uvea and epithelial cysts of the anterior chamber in 4 patients submitted to block excision and tectonic corneal graft between 2008 and 2012.

Methods: This is a retrospective, nonrandomized case series. Two patients were affected by anterior uveal malignant melanoma, and 2 patients were referred to us for large epithelial iris cysts with anterior chamber angle involvement and partial corneal failure. Read More

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http://dx.doi.org/10.1155/2019/4153064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525849PMC
May 2019
13 Reads

Diagnostic dilemma of ocular lymphoma.

BMJ Case Rep 2019 Jun 6;12(6). Epub 2019 Jun 6.

Singleton Hospital, Swansea, UK.

We report a very unusual presentation of primary intraocular lymphoma masquerading as anterior uveitis with atypical symptoms. A 68-year-old man, initially presented with a 4-day history of painless, left blurred vision. Examination revealed 2 or more anterior chamber cells, mutton-fat keratic precipitates and posterior synechiae. Read More

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http://dx.doi.org/10.1136/bcr-2019-229513DOI Listing
June 2019
16 Reads

[Bilateral iris mammillations: A case report].

J Fr Ophtalmol 2019 09 23;42(7):820-822. Epub 2019 May 23.

Service d'ophtalmologie, centre hospitalier universitaire Mohammed VI, BP 2360 Principal, avenue Ibn Sina, Marrakech, Maroc.

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http://dx.doi.org/10.1016/j.jfo.2019.03.006DOI Listing
September 2019

Pigmentation of conjunctival melanoma recurrences and outcome.

Graefes Arch Clin Exp Ophthalmol 2019 Aug 16;257(8):1783-1788. Epub 2019 May 16.

Department of Ophthalmology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.

Purpose: In primary conjunctival melanoma (CoM), one of the characteristics that is associated with an increased risk of metastases and death is a lack of tumour pigmentation. The aim of this study was to investigate whether the degree of pigmentation of CoM recurrences relates similarly to clinical outcome.

Methods: A data set of 177 patients with a CoM recurrence from the Wills Eye Hospital (USA) and the Leiden University Medical Center (The Netherlands) was analysed. Read More

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http://dx.doi.org/10.1007/s00417-019-04342-xDOI Listing
August 2019
6 Reads

Uveal melanoma: physiopathology and new in situ-specific therapies.

Cancer Chemother Pharmacol 2019 07 11;84(1):15-32. Epub 2019 May 11.

Department of Biology and Environment, University of Trás-os-Montes e Alto Douro, UTAD, Quinta de Prados, 5001-801, Vila Real, Portugal.

Uveal melanoma is the most common primary intraocular tumor in adults. It can arise from melanocytes in the anterior (iris) or posterior uveal tract (choroid and ciliary body). Uveal melanoma has a particular molecular pathogenesis, being characterized by specific chromosome alterations and gene mutations (e. Read More

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http://link.springer.com/10.1007/s00280-019-03860-z
Publisher Site
http://dx.doi.org/10.1007/s00280-019-03860-zDOI Listing
July 2019
22 Reads

Novel Eye Plaque Designs for Brachytherapy of Iris and Ciliary Body Melanoma and the First Clinical Application.

Ocul Oncol Pathol 2019 Apr 11;5(3):220-227. Epub 2018 Oct 11.

Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA.

Background: While traditional eye plaque brachytherapy can be used for the treatment of iris melanoma, it faces challenges of poor patient tolerability due to cornea-plaque touch caused by radius of curvature mismatch and potential dosimetric inaccuracy from incomplete coverage. We present novel plaque designs and the first clinical application of the plaques for iris melanoma.

Methods: Two dome-shaped plaques (EP2132 and EP1930) were designed to vault above the cornea to treat tumors of the iris and ciliary body. Read More

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http://dx.doi.org/10.1159/000493269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489066PMC
April 2019
13 Reads

Uveal Melanoma in Ireland.

Ocul Oncol Pathol 2019 Apr 13;5(3):195-204. Epub 2018 Sep 13.

Royal Victoria Eye and Ear Hospital, Dublin, Ireland.

Purpose: To report the clinical features and epidemiology of uveal melanoma in Ireland.

Methods: This was an observational study of 253 patients with a new diagnosis of uveal melanoma between June 2010 and December 2015. Main outcome measures included demographics, clinical features, age-adjusted incidence, relative survival, overall survival, and distant metastases-free survival. Read More

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https://www.karger.com/Article/FullText/492391
Publisher Site
http://dx.doi.org/10.1159/000492391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489068PMC
April 2019
29 Reads

Amelanotic Ciliochoroidal Melanoma in a Patient with Oculocutaneous Albinism.

Ocul Oncol Pathol 2019 Apr 3;5(3):182-185. Epub 2018 Sep 3.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

To report a case of amelanotic ciliochoroidal melanoma in a patient with oculocutaneous albinism. A 76-year-old Caucasian male with a past medical history of oculocutaneous albinism and recurrent urothelial carcinoma was found to have a mass in the left eye, suspicious for ciliochoroidal melanoma. On examination, visual acuity was 20/400 in both eyes (OU). Read More

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http://dx.doi.org/10.1159/000490913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489038PMC
April 2019
6 Reads

A Case of a Cavitary Iris Melanoma with Aqueous Cytological Modulation.

Ocul Oncol Pathol 2019 Apr 10;5(3):171-175. Epub 2018 Oct 10.

National Specialist Ophthalmic Pathology Service (NSOPS), Department of Histopathology, Royal Hallamshire Hospital, Sheffield, United Kingdom.

Malignant melanoma is the most common primary malignant tumour of the iris, but represents a small proportion of all uveal melanomas. The authors describe a 34-year-old male with a pigmented lesion of the iris. The lesion remained stable for 7 years, but the patient re-presented after this time with sudden enlargement of the mass and hyphaema. Read More

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http://dx.doi.org/10.1159/000493529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489039PMC
April 2019
2 Reads

Variability of Bad Prognosis in Uveal Melanoma.

Ophthalmol Retina 2019 02 21;3(2):186-193. Epub 2018 Sep 21.

Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Topic: Survival of patients with uveal melanoma classified to have a bad prognosis.

Clinical Relevance: To explore reasons for reported variability in survival of patients with uveal melanoma classified to have a bad prognosis.

Methods: We searched PUBMED, MEDLINE, and EMBASE for studies reporting survival data for uveal melanoma undergoing prognostic testing with chromosome 3 status by fluorescence in situ hybridization (FISH), comparative genomic hybridization (CGH), microsatellite analysis (MSA), multiplex ligation-dependent probe amplification (MLPA), single nucleotide polymorphism (SNP), gene expression profiling (GEP) class, and exon sequencing. Read More

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http://dx.doi.org/10.1016/j.oret.2018.09.007DOI Listing
February 2019
1 Read

Hemorrhagic occlusive retinal vasculitis leading to the diagnosis of ciliary body melanoma.

Saudi J Ophthalmol 2019 Jan-Mar;33(1):81-83. Epub 2018 Sep 24.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

Hemorrhagic occlusive retinal vasculitis (HORV) is a condition associated with intraocular vancomycin during surgical intervention, most frequently following bilateral sequential cataract surgery. Because of the high rate of ophthalmic vascular complications in this condition, gonioscopic evaluation for identification of neovascularization of the angle and iris is essential. Careful examination can reveal previously asymptomatic and unassociated lesions of the iris or ciliary body. Read More

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http://dx.doi.org/10.1016/j.sjopt.2018.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424716PMC
September 2018
7 Reads

Conservative management of suspicious melanocytic lesions of the iris.

Graefes Arch Clin Exp Ophthalmol 2019 Jun 27;257(6):1319-1324. Epub 2019 Mar 27.

Ocular Melanoma Center, Retina Service, Mass Eye and Ear, 243 Charles Street., Boston, MA, 02114, USA.

Purpose: The diagnosis of iris melanoma can be difficult, with no established diagnostic criteria currently available. Careful monitoring of patients with suspicious iris lesions is one approach to managing these tumors. We determined the risk of malignant transformation and melanoma-related mortality in patients under observation to evaluate the validity of this management approach. Read More

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http://dx.doi.org/10.1007/s00417-019-04296-0DOI Listing
June 2019
19 Reads

Size Matters: The Functional Role of the CEACAM1 Isoform Signature and Its Impact for NK Cell-Mediated Killing in Melanoma.

Cancers (Basel) 2019 Mar 13;11(3). Epub 2019 Mar 13.

Institute of Anatomy, Medical Faculty, University Duisburg-Essen, Essen 45147, Germany.

Malignant melanoma is the most aggressive and treatment resistant type of skin cancer. It is characterized by continuously rising incidence and high mortality rate due to its high metastatic potential. Various types of cell adhesion molecules have been implicated in tumor progression in melanoma. Read More

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https://www.mdpi.com/2072-6694/11/3/356
Publisher Site
http://dx.doi.org/10.3390/cancers11030356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468645PMC
March 2019
20 Reads

[Clinico-echographic diagnostics of iris tumors].

Ophthalmologe 2019 Apr;116(4):313-323

Zentrum für Augenheilkunde, Uniklinik Köln, Kerpener Str. 62, 50924, Köln, Deutschland.

Background: The differentiation of iridic space-occupying lesions represents a regularly reoccurring diagnostic challenge.

Objective: This article presents an overview of the epidemiological data and describes the diagnostic procedure for iris tumors.

Material And Methods: The article provides a review of the literature from PubMed and own clinical results. Read More

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http://dx.doi.org/10.1007/s00347-019-0861-yDOI Listing
April 2019
12 Reads

Very late recurrence of iris melanoma: 45 years after treatment.

Melanoma Res 2020 Jun;30(3):309-312

NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London Institute of Ophthalmology.

Iris melanoma is a rare tumour that accounts for ~3-4% of all uveal melanoma cases. In the past, surgical resection was the sole treatement option, whereas nowadays, it has been replaced by brachytherapy as treatment of choice. Surgical resection is still in use in selected cases but combined with adjuvant radiotherapy in cases of incomplete resection. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000581DOI Listing
June 2020
2 Reads
2.282 Impact Factor