1,371 results match your criteria Melanoma Conjunctival


Optic nerve invasion of non-juxtapapillary uveal melanoma: a rare occurrence.

BMJ Case Rep 2020 Jun 28;13(6). Epub 2020 Jun 28.

Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, India

A 44-year-old man presented with complaints of pain and discomfort in his left eye (OS). On examination, he had bare perception of light in OS and had a diffuse pigmented mass lesion in the nasal quadrant of the bulbar conjunctiva, associated with neovascularisation of the iris and iridocyclitis, with no fundus view. Intraocular pressure OS was 40 mm Hg. Read More

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http://dx.doi.org/10.1136/bcr-2020-234610DOI Listing

Image Analysis of 3D Conjunctival Melanoma Cell Cultures Following Electrochemotherapy.

Biomedicines 2020 Jun 13;8(6). Epub 2020 Jun 13.

Liverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, UK.

Three-dimensional (3D) cell cultures represent small avascular tumors in vitro and simulate some of the biological characteristics of solid tumors, enhancing the evaluation of anticancer drug efficacy. Automated image analysis can be used for the assessment of tumor growth and documentation of changes in the size parameters of 3D tumor spheroids following anticancer treatments such as electrochemotherapy. The objective of this article is to assess the effect of various electroporation (EP) conditions (500-750 Volts/cm, 8-20 pulses, 100 µs pulse duration, 5 Hz repetition rate) combined with different bleomycin concentrations (1-2. Read More

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http://dx.doi.org/10.3390/biomedicines8060158DOI Listing

Primary Conjunctival Pigmented Basal Cell Carcinoma with Increased Numbers of Intra-Tumour Melanocytes, Mimicking Melanoma: A Case Report and Review of the Literature.

Ocul Oncol Pathol 2020 May 29;6(3):168-173. Epub 2019 Nov 29.

Orbit and Oculoplastic Department, Chittagong Eye Infirmary and Training Complex (CEITC), Chittagong, Bangladesh.

A 60-year-old, South-Asian male patient presented with a dark brown lesion on his left conjunctiva surface near the limbus for 2 years. Examination showed a globular, dark brown-coloured mass near the temporal limbus at 4 to 5 o'clock position, measuring 3 × 3 × 2 mm. There were a few scattered flat pigmented lesions near the mass and also a few prominent vessels. Read More

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http://dx.doi.org/10.1159/000504413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250331PMC

Electrochemotherapy in 3D Ocular Melanoma Spheroids using a Customized Electrode.

J Vis Exp 2020 Apr 21(158). Epub 2020 Apr 21.

Department of Ophthalmology, University Hospital Halle (Saale), Martin-Luther University Halle-Wittenberg.

Electrochemotherapy (ECT) is the combination of transient pore formation following electric pulse application with the administration of cytotoxic drugs, which enhances the cytotoxic effect of the applied agent due to membrane changes. In vitro 3D culture systems simulate the in vivo tumor growth and preserve the biological characteristics of tumors more accurately than conventional monolayer cell cultures. We describe a protocol for the development of 3D tumor organoids using conjunctival melanoma (CM) and uveal melanoma (UM) cell lines as well as the use of hand-held customized electrodes, suitable for in vitro ECT in the culture well without destruction of the tumor environment. Read More

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http://dx.doi.org/10.3791/60611DOI Listing

Extra-Nodal Marginal Zone Lymphoma (MZL) of MALT CD20+ of the Ocular Adnexa: Case Report.

Maedica (Buchar) 2020 Mar;15(1):126-128

Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia.

Even though rare in the orbital region, lymphomas are reported as the third most common malignancies of the conjunctiva, following squamous cell carcinoma and melanoma. It is estimated that more than 95% lymphomas in periocular tissues are B cell in origin. We present a case of extra-nodal marginal zone lymphoma (MZL) of MALT type of the ocular adnexa, successfully treated with chemoimmunotherapy R-CVP. Read More

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http://dx.doi.org/10.26574/maedica.2020.15.1.126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221267PMC

Conjunctival melanoma: A 20-year survey in a comprehensive medical center.

J Formos Med Assoc 2020 May 14. Epub 2020 May 14.

Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan; Chang Gung University, College of Medicine, Taoyuan, Taiwan. Electronic address:

Background: To better understand population-specific tumor characteristics and behavior of conjunctival melanoma in Asian.

Methods: A retrospective cohort enrolled patients with primary conjunctival melanoma treated and followed up at Chang Gung Memorial Hospital (CGMH) in Taiwan between 1995 and 2015. Basic characteristics such as age, gender, tumor size, cell type, location, and TNM stage were recorded. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.04.032DOI Listing

[Management of ocular cancer during COVID-19 pandemic].

Authors:
N Cassoux

J Fr Ophtalmol 2020 Jun 30;43(6):545-546. Epub 2020 Apr 30.

Département Ophtalmologie, Institut Curie, Oncologie Chirurgicale, 26, rue d'ULM, 750005 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jfo.2020.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190518PMC

Delayed Onset Scleromalacia and Conjunctival Bleb Formation Following Intraoperative Mitomycin C Application during Conjunctival Melanoma Excision.

Vision (Basel) 2020 May 6;4(2). Epub 2020 May 6.

Sussex Eye Hospital, Brighton & Sussex University Hospitals NHS Trust, Eastern Road, Brighton BN2 5BF, UK.

Purpose: To present a case of delayed onset scleromalacia and conjunctival bleb formation one year after conjunctival melanoma excision with intraoperative use of mitomycin-C (MMC) and double-freeze-thaw technique.

Methods: Case report.

Results: A 69-year-old woman had a conjunctival melanoma excised by the 'no touch technique' with intraoperative application of 0. Read More

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http://dx.doi.org/10.3390/vision4020024DOI Listing

Rapid Rehabilitation With Skin-Muscle Sparing Orbital Exenteration: A Single-Center Series.

Ophthalmic Plast Reconstr Surg 2020 May 4. Epub 2020 May 4.

Adnexal Service, Moorfields Eye Hospital, London, United Kingdom.

Aims: To examine the features and clinical management of patients who underwent skin-muscle sparing orbital exenteration in a tertiary referral center.

Patients And Method: Retrospective case-note review for patients undergoing skin-muscle sparing orbital exenteration at Moorfields Eye Hospital between 1997 and 2012. Patient demographics, clinical features, histopathology, clearance, surgery, adjuvant therapy, and outcomes were analyzed. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001677DOI Listing

Expression of the COVID-19 receptor ACE2 in the human conjunctiva.

J Med Virol 2020 May 6. Epub 2020 May 6.

Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Germany.

SARS-CoV-2 is assumed to use angiotensin-converting enzyme 2 (ACE2) and other auxiliary proteins for cell entry. Recent studies have described conjunctival congestion in 0.8% of patients with laboratory-confirmed SARS-CoV-2, and there has been speculation that SARS-CoV-2 can be transmitted through the conjunctiva. Read More

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http://dx.doi.org/10.1002/jmv.25981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267303PMC

Management of conjunctival melanoma with local excision and adjuvant brachytherapy.

Eye (Lond) 2020 Apr 24. Epub 2020 Apr 24.

Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.

Background/objectives: To evaluate the management of conjunctival melanoma with local excision and adjuvant brachytherapy.

Subjects/methods: Data of all patients who received local excision and adjuvant brachytherapy for conjunctival melanoma between 1999 and 2016 in a Dutch national referral centre were reviewed. A protocol with Sr-90 was used until 2012, a protocol with Ru-106 was used hereafter. Read More

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http://dx.doi.org/10.1038/s41433-020-0879-zDOI Listing

Differential diagnosis and management of melanocytic lesions of the ocular surface

Orv Hetil 2020 04 1;161(15):563-574. Epub 2020 Apr 1.

Semmelweis Egyetem, Budapest, Mária u. 39., 1085.

Our purpose is to summarize the actual knowledge about melanocytic lesions of the ocular surface (conjunctival nevus, primary acquired melanosis and conjunctival melanoma),especially their clinical appearance, differential diagnosis and treatment. Conjunctival nevus is the most common benign, conjunctival melanocytic lesion. Primary acquired melanosis mainly presents in middle-aged or elderly individuals, characterized by proliferation of melanocytes of the conjunctival epithelial layer. Read More

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http://dx.doi.org/10.1556/650.2020.31699DOI Listing

Children with malignant melanoma: a single center experience from Turkey.

Turk Pediatri Ars 2020 9;55(1):39-45. Epub 2020 Mar 9.

Department of Pediatric Hematology-Oncology, İstanbul University, Oncology Institute, İstanbul, Turkey.

Aim: Malignant melanoma is the most frequent skin cancer in children and adolescents. It comprises 1-3% of all malignancies. In this study, we aimed to evaluate the clinical aspects, histopathologic features, and treatment outcomes of our patients with malignant melanoma. Read More

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http://dx.doi.org/10.14744/TurkPediatriArs.2019.90022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096563PMC

Intradural Extramedullary Metastatic Conjunctival Malignant Melanoma.

World Neurosurg 2020 Jun 23;138:444-448. Epub 2020 Mar 23.

Department of Pathology, Dongguk University Ilsan Hospital, Goyang, South Korea.

Background: Intradural extramedullary (IDEM) metastatic spine tumors of nonneurogenic origin, excluding leptomeningeal seeding, are very rare. Most patients with IDEM metastatic spine tumors of nonneurogenic origin have coexisting brain metastasis. We report a case of IDEM metastatic malignant melanoma without antecedent or coexisting brain metastasis. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.03.078DOI Listing

Controlling Conjunctival Melanoma-To Infinity and Beyond.

JAMA Ophthalmol 2020 Mar 26. Epub 2020 Mar 26.

Department of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1001/jamaophthalmol.2020.0522DOI Listing

Incidence and Survival of Patients With Conjunctival Melanoma in Europe.

JAMA Ophthalmol 2020 Mar 26. Epub 2020 Mar 26.

Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Importance: Conjunctival melanoma (CM) is a rare ocular tumor. Estimates of incidence and survival of patients with CM are important to researchers and policy makers.

Objective: To estimate incidence and survival of patients with CM in Europe. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2020.0531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099468PMC

Conjunctival Fungal Ball Mimicking Melanoma.

Ophthalmology 2020 Apr;127(4):534

Glick Eye Institute, Indiana University School of Medicine, Indianapolis, Indiana.

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http://dx.doi.org/10.1016/j.ophtha.2019.12.027DOI Listing

TLD1433 Photosensitizer Inhibits Conjunctival Melanoma Cells in Zebrafish Ectopic and Orthotopic Tumour Models.

Cancers (Basel) 2020 Mar 4;12(3). Epub 2020 Mar 4.

Institute of Biology, Leiden University, 2333 CC Leiden, The Netherlands.

The ruthenium-based photosensitizer (PS) TLD1433 has completed a phase I clinical trial for photodynamic therapy (PDT) treatment of bladder cancer. Here, we investigated a possible repurposing of this drug for treatment of conjunctival melanoma (CM). CM is a rare but often deadly ocular cancer. Read More

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http://dx.doi.org/10.3390/cancers12030587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139549PMC

Conjunctival melanoma in an African American man.

Am J Ophthalmol Case Rep 2020 Jun 26;18:100641. Epub 2020 Feb 26.

University of Illinois at Chicago, Department of Ophthalmology and Visual Sciences, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.ajoc.2020.100641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049596PMC

Conjunctival Melanoma: Features and Outcomes Based on the Fitzpatrick Skin Type in 540 Patients at a Single Ocular Oncology Center.

Ophthalmic Plast Reconstr Surg 2020 Mar 2. Epub 2020 Mar 2.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.

Purpose: To determine the association of Fitzpatrick skin type (FST) with conjunctival melanoma.

Methods: Retrospective case series of 540 patients with conjunctival melanoma to assess clinical features and outcomes per FST.

Results: The FST was Type I (n = 126, 23%), II (n = 337, 62%), III (n = 56, 10%), IV (n = 8, 2%), V (n = 12, 2%), and VI (n = 1, <1%). Read More

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http://dx.doi.org/10.1097/IOP.0000000000001624DOI Listing

First case of melanoma-associated retinopathy with conjunctival melanoma.

Can J Ophthalmol 2020 Feb 21. Epub 2020 Feb 21.

University of Sherbrooke, Sherbrooke, Que.. Electronic address:

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http://dx.doi.org/10.1016/j.jcjo.2020.01.006DOI Listing
February 2020

Dabrafenib and Trametinib for BRAF-Mutated Conjunctival Melanoma.

Ocul Oncol Pathol 2020 Jan 26;6(1):35-38. Epub 2019 Jul 26.

Department of Ophthalmology and Visual Science at Yale University School of Medicine, New Haven, Connecticut, USA.

Background: Conjunctival melanoma is a potentially lethal malignancy of the ocular surface. There have been no therapeutic advancements made in the past several decades despite increasing prevalence of the disease.

Methods: The authors report the case of a 52-year-old Caucasian male with unresectable, recurrent conjunctival melanoma with V600 mutation who was treated with systemic BRAF/MEK inhibition. Read More

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http://dx.doi.org/10.1159/000497473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984155PMC
January 2020

Conjunctival Melanoma: Current Treatments and Future Options.

Am J Clin Dermatol 2020 Jun;21(3):371-381

Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, USA.

Conjunctival melanoma is a rare tumor of the conjunctival epithelium with a heterogenous clinical presentation and a propensity for regional and distant metastatic spread. Guidelines for the treatment of local conjunctival melanoma are well-established, but there are no standard efficacious therapies for metastatic disease. Given that conjunctival melanoma is genetically similar to cutaneous melanoma and mucosal melanomas, targeted therapies effective in the treatment of these diseases, such as BRAF inhibitors and KIT inhibitors, may be effective in the treatment of patients with metastatic conjunctival melanoma. Read More

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http://dx.doi.org/10.1007/s40257-019-00500-3DOI Listing

Orbital exenteration and conjunctival melanoma: a 14-year study at the Jules Gonin Eye Hospital.

Eye (Lond) 2020 Jan 20. Epub 2020 Jan 20.

Ophthalmology Department, Jules Gonin Eye Hospital, Lausanne, Switzerland.

Purpose: To report our 14-year experience with orbital exenteration and assess risk factors for poor prognosis by focusing on conjunctival melanoma.

Patients And Method: A retrospective study was conducted in our tertiary care centre (Jules Gonin Eye Hospital, Lausanne, Switzerland) between 2003 and 2017. Inclusion criteria were patients aged  ≥18 years with a follow-up >12 months, without metastatic spread at the time of surgery. Read More

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http://dx.doi.org/10.1038/s41433-020-0767-6DOI Listing
January 2020

[Personalized medicine in the treatment of periocular tumors : Targeted treatment and use of immune checkpoint inhibitors].

Ophthalmologe 2020 Jun;117(6):521-527

Zentrum für Augenheilkunde, Universität zu Köln, Medizinische Fakultät und Universitätsklinikum Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

The aim of this article is to provide an overview on the current state of personalized medicine in the systemic treatment of selected periocular tumors, such as basal cell carcinoma, Merkel cell carcinoma and conjunctival melanoma. This article therefore provides an extensive current literature review from PubMed including the current guidelines and standard operating procedures (SOP). As 90% of basal cell carcinomas have a pathologic activation of the sonic hedgehog pathway, vismodegib is a new treatment option for inoperable or metastatic basal cell carcinoma and for patients with Gorlin-Goltz syndrome. Read More

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http://dx.doi.org/10.1007/s00347-019-01034-zDOI Listing

Conjunctival melanoma in patients with xeroderma pigmentosum: a series of four cases.

Int Ophthalmol 2020 May 13;40(5):1143-1146. Epub 2020 Jan 13.

Operation Eyesight Universal Institute for Eye Cancer (VHV, SK), L V Prasad Eye Institute, Hyderabad, 500034, India.

Purpose: To study the demographic features, treatment, histopathology, and outcomes in patients of xeroderma pigmentosum (XP) with conjunctival melanoma.

Methods: Retrospective case series.

Results: The median age at presentation was 18 years (range 9-30 years). Read More

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http://dx.doi.org/10.1007/s10792-019-01279-2DOI Listing

A pigmented lesion on the eye.

BMJ 2020 01 9;368:l6810. Epub 2020 Jan 9.

Department of Ophthalmology & Visual Sciences, W K Kellogg Eye Center, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1136/bmj.l6810DOI Listing
January 2020

Transformation of a naevus into a mixed pyogenic granuloma-naevus mimicking conjunctival melanoma.

Pathology 2020 Feb 27;52(2):269-271. Epub 2019 Dec 27.

Eye Center, University Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2019.09.018DOI Listing
February 2020

Oncologic and visual outcomes after postoperative proton therapy of localized conjunctival melanomas.

Radiat Oncol 2019 Dec 27;14(1):239. Epub 2019 Dec 27.

Department of Ophthalmology, Pasteur 2 Teaching Hospital, Nice, France.

Introduction: conjunctival melanomas have high local relapse rates. Oncologic and visual outcomes can be improved with proton therapy and no-touch surgery.

Material And Methods: a monocentric retrospective study of consecutive patients treated with surgery and proton therapy for conjunctival melanoma was conducted. Read More

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http://dx.doi.org/10.1186/s13014-019-1426-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935064PMC
December 2019

Conjunctival Melanoma Treated With Complete Circumferential Peripheral and Deep Margin Assessment ("Slow Mohs") Surgery.

Dermatol Surg 2019 Dec 13. Epub 2019 Dec 13.

Department of Medicine, Division of Dermatology, Washington University in St. Louis School of Medicine, St. Louis, Missouri Department of Ophthalmology and Visual Sciences, Washington University in St. Louis School of Medicine, St. Louis, Missouri Department of Medicine, Division of Dermatology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1097/DSS.0000000000002283DOI Listing
December 2019

Immunohistochemical analysis of benign and malignant melanocytic lesions of the conjunctiva using double-staining.

Can J Ophthalmol 2019 12 14;54(6):699-707. Epub 2019 Jun 14.

Department of Ophthalmology, The Ottawa Hospital, University of Ottawa, Ottawa, Ont.; Department of Pathology, The Ottawa Hospital, University of Ottawa, Ottawa, Ont.

Objective: To implement a double-staining technique to identify the most sensitive and specific combinations of melanoma antigen recognized by T cells (Melan-A), microphthalmia-associated transcription factor (MITF), human melanoma black 45 (HMB45), and Ki67 aiming to assist in the diagnosis of atypical melanocytic conjunctival lesions that are more prone to malignant progression.

Methods: Eight specimens of conjunctival melanoma and of primary acquired melanosis with moderate to severe atypia were double-immunostained with a combination of a cytoplasmic marker (anti-Melan-A or anti-HMB45), and a nuclear marker (anti-MITF or anti-Ki67). Eight specimens of normal conjunctiva and of conjunctival nevi served as controls. Read More

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http://dx.doi.org/10.1016/j.jcjo.2019.03.015DOI Listing
December 2019

[Does orbital exenteration still has a place in 2019?]

J Fr Ophtalmol 2020 Feb 9;43(2):152-174. Epub 2019 Dec 9.

Service de chirurgie oncologique cervico-faciale, centre Antoine Lacassagne, 06189 Nice, France.

Introduction: Orbital exenteration is a radical anatomically and psychologically disfiguring procedure. It is mostly performed for management of orbital cancers or cancers with orbital involvement. The lack of benefit in terms of overall survival and the development of new molecular therapies (targeted therapies, immunotherapy) in recent years leads us to question its use. Read More

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http://dx.doi.org/10.1016/j.jfo.2019.04.021DOI Listing
February 2020

Sebaceous carcinoma: evidence-based clinical practice guidelines.

Lancet Oncol 2019 12;20(12):e699-e714

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address:

Sebaceous carcinoma usually occurs in adults older than 60 years, on the eyelid, head and neck, and trunk. In this Review, we present clinical care recommendations for sebaceous carcinoma, which were developed as a result of an expert panel evaluation of the findings of a systematic review. Key conclusions were drawn and recommendations made for diagnosis, first-line treatment, radiotherapy, and post-treatment care. Read More

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http://dx.doi.org/10.1016/S1470-2045(19)30673-4DOI Listing
December 2019
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Conjunctival pigmented lesion: Clinicopathological analysis of 85 cases in Korean population.

Sci Rep 2019 12 3;9(1):18204. Epub 2019 Dec 3.

Department of Ophthalmology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.

To evaluate histopathological characteristics of conjunctival pigmented lesions and analyze clinical features related to histologic classification in Asian population, we analyzed medical records, anterior segment photographs, and histological specimen of 85 eyes who had undergone biopsy for pigmented conjunctival lesions at Seoul National University Hospital between 1999 and 2018. Compound nevus was the most common type of conjunctival pigmented lesions (67.1%), followed by conjunctival melanocytic intraepithelial neoplasia (primary acquired melanosis)(11. Read More

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http://dx.doi.org/10.1038/s41598-019-54786-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890774PMC
December 2019

Effective conservative management of locally advanced conjunctival melanoma using initial systemic therapy.

Clin Exp Ophthalmol 2020 Apr 6;48(3):402-404. Epub 2019 Dec 6.

The Kinghorn Cancer Centre, St Vincent's Hospital, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/ceo.13691DOI Listing

Conjunctival Melanoma in Childhood and Adolescence: A Systematic Review.

Ocul Oncol Pathol 2019 Oct 10;5(6):387-395. Epub 2019 Apr 10.

Sydney Children's Hospital, Randwick, New South Wales, Australia.

Background: Conjunctival melanoma is rare in adults and rarer in children. We systematically reviewed the presentation, diagnostic and management strategies as well as outcomes for conjunctival melanoma in children and adolescents.

Methods: The following databases were searched: Medline, Embase, Web of Science and Scopus for cases of conjunctival melanoma occurring in children and adolescents < 18 years of age. Read More

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http://dx.doi.org/10.1159/000497813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873081PMC
October 2019

MicroRNA Profiling in Benign and Malignant Conjunctival Melanocytic Lesions.

Ophthalmology 2020 03 12;127(3):432-434. Epub 2019 Oct 12.

Section Ophthalmic Pathology, Department of Pathology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands; The Rotterdam Eye Hospital, Rotterdam, the Netherlands; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ophtha.2019.10.008DOI Listing

Conjunctival melanoma with orbital invasion and liver metastasis managed with systemic immune checkpoint inhibitor therapy.

Indian J Ophthalmol 2019 12;67(12):2071-2073

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

A 60-year-old Caucasian female was referred for biopsy-proven amelanotic orbito-conjunctival melanoma. Map biopsies revealed residual invasive melanoma on the deep tarsal margin at the site of previous surgery. Repeat excisions were required after recurrence was detected following 3 months and 7 months. Read More

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http://dx.doi.org/10.4103/ijo.IJO_663_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896557PMC
December 2019

Ipsilateral presentation of ocular surface squamous neoplasia and conjunctival melanoma in xeroderma pigmentosum: A rare occurrence.

Indian J Ophthalmol 2019 12;67(12):2068-2071

Laboratory Services, Dr Shroff's Charity Eye Hospital, New Delhi, India.

A case of a 16-year-old male with xeroderma pigmentosum (XP) who presented with multiple pigmented and nonpigmented conjunctival lesions in both eyes is reported. He had a keratinized lesion at the limbus and a pigmented lesion in bulbar conjunctiva in the left eye and multiple pigmented bulbar conjunctival lesions and a keratinized limbal nodule in the right eye. Excision biopsy confirmed the diagnosis of ocular surface squamous neoplasia (OSSN) and conjunctival intraepithelial melanocytic neoplasia-2 (CIMN-2) in the right eye and OSSN and conjunctival melanoma in situ (CIMN-5) in the left eye. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1449_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896572PMC
December 2019

Evaluation of PD-L1 and PD-1 expression in aggressive eyelid sebaceous gland carcinoma and its clinical significance.

Indian J Ophthalmol 2019 12;67(12):1983-1987

Department of Ocular Pathology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: Eyelid sebaceous gland carcinoma (SGC) is an aggressive but rare malignancy of ocular region. Over-expression of PD-L1 and PD-1 has been demonstrated in a variety of solid tumors including conjunctival melanoma. PD-L1 is an immunoinhibitory molecule that suppresses the effective T cells response against tumor antigen leading to the progression of tumors. Read More

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http://dx.doi.org/10.4103/ijo.IJO_2056_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896547PMC
December 2019

Tumors of the conjunctiva and cornea.

Indian J Ophthalmol 2019 12;67(12):1930-1948

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Tumors of the conjunctiva and cornea comprise a large and varied spectrum of conditions. These tumors are grouped into two major categories of congenital and acquired lesions. The acquired lesions are further subdivided based on origin of the mass into surface epithelial, melanocytic, vascular, fibrous, neural, histiocytic, myxoid, myogenic, lipomatous, lymphoid, leukemic, metastatic and secondary tumors. Read More

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http://dx.doi.org/10.4103/ijo.IJO_2040_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896532PMC
December 2019

mA modification suppresses ocular melanoma through modulating HINT2 mRNA translation.

Mol Cancer 2019 11 14;18(1):161. Epub 2019 Nov 14.

Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 20025, People's Republic of China.

Background: Dynamic N-methyladenosine (mA) RNA modification generated and erased by N-methyltransferases and demethylases regulates gene expression, alternative splicing and cell fate. Ocular melanoma, comprising uveal melanoma (UM) and conjunctival melanoma (CM), is the most common primary eye tumor in adults and the 2nd most common melanoma. However, the functional role of mA modification in ocular melanoma remains unclear. Read More

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http://dx.doi.org/10.1186/s12943-019-1088-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854757PMC
November 2019
4.257 Impact Factor

β-Catenin Expression and Activation in Conjunctival Melanoma.

Dermatopathology (Basel) 2019 Apr-Jun;6(2):50-62. Epub 2019 Jun 26.

Jules-Gonin Eye Hospital, Lausanne University, FAA, Lausanne, Switzerland.

Purpose: To assess the role of the canonical Wnt pathway via activation of β-catenin in tumor progression of conjunctival melanoma.

Methods: β-Catenin localization was assessed by immunohistochemistry in 43 conjunctival nevi, 48 primary acquired melanoses (PAM; conjunctival melanocytic intraepithelial neoplasia), and 44 conjunctival melanomas. Activation of the canonical or the noncanonical Wnt pathway was tested in vitro in 4 conjunctival melanoma cell lines with stimulation of either Wnt5a or Wnt3a. Read More

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http://dx.doi.org/10.1159/000500682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827456PMC

Management Issues in Conjunctival Tumours: Conjunctival Melanoma and Primary Acquired Melanosis.

Ophthalmol Ther 2019 Dec 6;8(4):501-510. Epub 2019 Nov 6.

Ocular Oncology Service, Moorfields Eye Hospital and St Bartholomew's Hospital, London, UK.

Conjunctival melanoma is a rare malignant condition of the ocular surface. It is potentially lethal, with regional lymph node spread often preceding distant solid-organ metastasis. Due to its rarity and the long latency between treatment and local recurrence or the development of metastases, it is difficult to study. Read More

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http://dx.doi.org/10.1007/s40123-019-00219-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858423PMC
December 2019
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Conjunctival Melanoma: Genetic and Epigenetic Insights of a Distinct Type of Melanoma.

Int J Mol Sci 2019 Oct 31;20(21). Epub 2019 Oct 31.

Medical Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.

Conjunctival melanoma (CjM) is a rare, primary cancer of the ocular region. Genetic and epigenetic characteristics of conjunctival melanoma have not been completely elucidated yet. Conjunctival melanoma presents similarities with cutaneous melanoma, with substantial differences in the biological behavior. Read More

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http://dx.doi.org/10.3390/ijms20215447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862213PMC
October 2019

Integrative Exome and Transcriptome Analysis of Conjunctival Melanoma and Its Potential Application for Personalized Therapy.

JAMA Ophthalmol 2019 Oct 24. Epub 2019 Oct 24.

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor.

Importance: Greater understanding of molecular features of conjunctival melanoma (CM) may improve its clinical management.

Objective: To evaluate molecular features of CM and application of this information into clinical care.

Design, Setting, And Participants: In a prospective case series of CM with integrative exome and transcriptome analysis, 8 patients at an academic ocular oncology setting were evaluated. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2019.4237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813594PMC
October 2019

A simple pingueculum or not?

Indian J Ophthalmol 2019 11;67(11):1792

Wills Eye Hospital, Philadelphia, PA, USA.

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http://dx.doi.org/10.4103/ijo.IJO_1831_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836611PMC
November 2019

[Current Therapies in Superficial Malignant Tumors].

Laryngorhinootologie 2019 Oct 14;98(10):685-694. Epub 2019 Oct 14.

Zentrum für Augenheilkunde, Universitätsklinikum Essen, Essen.

This article is a review of diagnostic and therapeutic possibilities in common epibulbar malignant tumors, such as basal cell carcinoma, conjunctival lymphoma, squamous cell carcinoma and conjunctival melanoma. Most importantly, for every tumor patient there is a detailed anamnesis, split lamp examination and photo documentation. Further regular controls after therapy are required due to the risk of recurrences. Read More

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http://dx.doi.org/10.1055/a-0960-6490DOI Listing
October 2019
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The Cold Case of Metabotropic Glutamate Receptor 6: Unjust Detention in the Retina?

Curr Neuropharmacol 2020 ;18(2):120-125

Department of Experimental Medicine, Pharmacology Division, University of Campania "L. Vanvitelli", Naples, Italy.

It is a common opinion that metabotropic glutamate receptor subtype 6 (mGluR6) is expressed exclusively in the retina, and in particular in the dendrites of ON-bipolar cells. Glutamate released in darkness from photoreceptors activates mGluR6, which is negatively associated with a membrane non-selective cation channel, the transient receptor potential melanoma-related 1, TRPM1, resulting in cell hyperpolarization. The evidence that mGluR6 is expressed not only in the retina but also in other tissues and cell populations has accumulated over time. Read More

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http://dx.doi.org/10.2174/1570159X17666191001141849DOI Listing
January 2020
2 Reads