1,287 results match your criteria Melanoma Conjunctival


Neurothekeoma of the eye, conjunctiva and periorbital adnexa. Report of two cases and brief review.

Surv Ophthalmol 2019 Apr 9. Epub 2019 Apr 9.

Departments of Ophthalmology and Pathology, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address:

Neurothekeomas (NTK) are benign soft tissue tumors most commonly occurring in the head, neck and upper extremities of young adults, with a female preponderance. Herein we report 2 cases of ocular NTK presenting as an orbital mass or chalazion. Both cases underwent excision of the mass with histopathologic diagnosis of cellular NTK. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.04.002DOI Listing
April 2019
1 Read

Interferon Alpha 2a and 2b in Ophthalmology: A Review.

J Interferon Cytokine Res 2019 Apr 5. Epub 2019 Apr 5.

1 Department and Clinic of Ophthalmology, University of Wrocław Medical College, Wrocław, Poland.

Interferon alpha (IFN-α) is a glycoprotein with antitumor, antiviral, and immunomodulatory activity, used widely in the treatment of viral infections (hepatitis B and C, condylomata acuminata, herpes zoster, etc.), hematological disorders (leukemia, multiple myeloma, T cell lymphoma, and essential thrombocythemia), and solid tumors (clear cell carcinoma in the metastatic stage, melanoma, hepatocellular carcinoma, and cervical neoplasia). Studies have proven the effectiveness of IFN-α in the treatment of ophthalmic disorders involving the anterior segment of the eye (conjunctival papilloma, squamous neoplasia, conjunctival mucosa-associated lymphoid tissue, Mooren's ulcer, and vernal keratoconjunctivitis) and the posterior segment of the eye (serpiginous choroidopathy, posterior uveitis, pseudophakic and diabetic cystoid macular edema, and proliferative diabetic retinopathy). Read More

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https://www.liebertpub.com/doi/10.1089/jir.2018.0125
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http://dx.doi.org/10.1089/jir.2018.0125DOI Listing
April 2019
3 Reads

Global microRNA profiling of metastatic conjunctival melanoma.

Melanoma Res 2019 Mar 29. Epub 2019 Mar 29.

Department of Pathology, Eye Pathology Section.

This study aimed to investigate the microRNA (miRNA) profile in primary tumors from conjunctival melanoma with and without subsequent metastatic spread along with their coupled distant metastases to identify miRNAs likely to be involved in metastatic progression. This observational study included 13 patients with metastatic conjunctival melanoma (follow-up: 1-39 years) treated at a Danish referral center. Twenty-five patients with nonmetastatic conjunctival melanoma (follow-up: 5-17 years) were included for comparison. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000606DOI Listing
March 2019
1 Read
2.282 Impact Factor

Proton radiotherapy in advanced malignant melanoma of the conjunctiva.

Graefes Arch Clin Exp Ophthalmol 2019 Mar 27. Epub 2019 Mar 27.

Department of Radiation Therapy, University Hospital Essen, Hufelandstrasse 55, 45147, Essen, Germany.

Background: The management of conjunctival melanoma is challenging and frequently ends in exenteration. The aim of this retrospective study was to evaluate the long-term results of proton beam radiation with regard to various clinical parameters.

Methods: Eighty-nine patients with extended conjunctival melanoma (≥T2) and multifocal bulbar located tumors (T1c/d) were treated consecutively with proton radiotherapy (dose 45 Gy). Read More

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http://dx.doi.org/10.1007/s00417-019-04286-2DOI Listing
March 2019
1 Read

Checkpoint inhibition immunotherapy for advanced local and systemic conjunctival melanoma: a clinical case series.

J Immunother Cancer 2019 Mar 25;7(1):83. Epub 2019 Mar 25.

New York University Cancer Institute, 160 East 34th Street, New York, NY, 10016, USA.

Background: Herein, we describe the use of systemic immunotherapy for both locally advanced and metastatic conjunctival melanoma. Current treatments for advanced conjunctival melanoma typically result in poor local control leading to disfiguring orbital exenteration surgery. Locoregional spread of conjunctival malignant melanoma typically requires pre-auricular and cervical lymph node dissection with post-operative adjuvant radiation therapy. Read More

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http://dx.doi.org/10.1186/s40425-019-0555-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434860PMC

Altered expression profile of circular RNAs in conjunctival melanoma.

Epigenomics 2019 Mar 20. Epub 2019 Mar 20.

Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 12, Lane 833, Zhizaoju Road, Huangpu District, Shanghai 200001, China.

Aim: We aimed to explore the roles of circular RNA (circRNA) in conjunctival melanoma.

Materials & Methods: The altered circRNAs were identified by RNA sequencing. The function of one circRNA, circMTUS1, was explored by several experiments in conjunctival melanoma. Read More

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http://dx.doi.org/10.2217/epi-2019-0029DOI Listing
March 2019
1 Read

Recurrent hotspot SF3B1 mutations at codon 625 in vulvovaginal mucosal melanoma identified in a study of 27 Australian mucosal melanomas.

Oncotarget 2019 Jan 29;10(9):930-941. Epub 2019 Jan 29.

Melanoma Institute Australia, The University of Sydney, Sydney, Australia.

Introduction: Clinical outcomes for mucosal melanomas are often poor due to a lack of effective systemic drug therapies. Identifying driver genes in mucosal melanoma may enhance the understanding of disease pathogenesis and provide novel opportunities to develop effective therapies.

Results: Somatic variant analysis identified (6 of 27: 22%) as the most commonly mutated gene, followed by (3 of 27: 11%). Read More

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http://dx.doi.org/10.18632/oncotarget.26584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398173PMC
January 2019

A retrospective review of conjunctival melanoma: Presentation, treatment and evolution.

Arch Soc Esp Oftalmol 2019 Mar 4. Epub 2019 Mar 4.

Unidad de Tumores del Adulto, Servicio de Oftalmología, Hospital Clínico Universitario de Valladolid, Valladolid, España.

Objective: The purpose of the present study is to describe the clinical characteristics and outcomes of patients diagnosed and treated for conjunctival melanoma in the Ocular Oncology Unit of the University Hospital Clinic of Valladolid.

Methods: A retrospective observational case series study was conducted on patients diagnosed with conjunctival melanoma in the Ocular Oncology Unit of University Hospital Clinic of Valladolid, from January 1992 to December 2017. Demographic information and tumour features were recorded in a Microsoft Access database. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03656691193004
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http://dx.doi.org/10.1016/j.oftal.2019.01.008DOI Listing
March 2019
5 Reads

Corneal ulceration associated with Nivolumab use.

Am J Ophthalmol Case Rep 2019 Jun 7;14:26-27. Epub 2019 Feb 7.

Parker Cornea, 1720 University Blvd Suite 503, Birmingham, AL, 35233, USA.

Purpose: To describe a case of corneal ulceration associated with Nivolumab use.

Observations: An 80-year-old woman treated with Nivolumab for metastatic melanoma developed an intractable corneal ulcer in her left eye, refractory to all therapies - including surgery to cover the ulcer with a conjunctival flap - until topical prednisolone acetate was tried, which was curative.

Conclusions And Importance: Nivolumab use may be associated with a form of steroid-responsive corneal ulceration. Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377387PMC

The Amazon Ocular Oncology Center: The first three years.

Arq Bras Oftalmol 2019 Mar-Apr;82(2):107-110. Epub 2019 Jan 24.

Centro de Oncologia Ocular, Departamento de Ofalmologia e Ciências Visuais, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Purpose: To evaluate the first three years of The Amazon Ocular Oncology Center, the first ocular cancer center in the North of Brazil.

Methods: Here, we report patient information including patients' age, gender, diagnosis, treatment, and city of origin.

Results: Two hundred and twenty-one patients were included on this study: 160 (72%) patients came from the city of Manaus, 52 (24%) from other cities in Amazonas, and 9 (4%) from other states. Read More

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http://dx.doi.org/10.5935/0004-2749.20190024DOI Listing
January 2019
1 Read

Clinicopathological study of malignant melanoma in a regional cancer center.

Indian J Cancer 2018 Jul-Sep;55(3):292-296

Department of Pathology, A.H. Regional Cancer Centre, Cuttack, Odisha, India.

Background: : Malignant melanoma is a tumor of melanocytic origin. Although uncommon in India as compared with the west, its prevalence is increasing.

Objectives: To document the pattern of clinicopathological features of malignant melanoma cases attending in a regional cancer center in eastern India. Read More

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http://dx.doi.org/10.4103/ijc.IJC_612_17DOI Listing
January 2019
7 Reads

Oculodermal Melanocytosis: Nevus of Ota in a Dog.

Vet Pathol 2019 Jan 27:300985818823667. Epub 2019 Jan 27.

1 Optivet Referrals, Havant, Hampshire, UK.

This report describes the clinical presentation, diagnosis, and histopathologic features of oculodermal melanocytosis in a young dog. A 3-year-old male neutered Labrador Retriever presented with conjunctival and scleral hyperpigmentation of the right eye, with concurrent ipsilateral cutaneous hyperpigmentation involving the right side of the face. Initial skin and conjunctival biopsies revealed an accumulation of histologically benign melanocytes within the dermis and conjunctival stroma, respectively. Read More

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http://dx.doi.org/10.1177/0300985818823667DOI Listing
January 2019
6 Reads

Conjunctival melanoma copy number alterations and correlation with mutation status, tumor features, and clinical outcome.

Pigment Cell Melanoma Res 2019 Jan 23. Epub 2019 Jan 23.

Liverpool Ocular Oncology Research Group, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

Relatively little is known about the genetic aberrations of conjunctival melanomas (CoM) and their correlation with clinical and histomorphological features as well as prognosis. The aim of this large collaborative multicenter study was to determine potential key biomarkers for metastatic risk and any druggable targets for high metastatic risk CoM. Using Affymetrix single nucleotide polymorphism genotyping arrays on 59 CoM, we detected frequent amplifications on chromosome (chr) 6p and deletions on 7q, and characterized mutation-specific copy number alterations. Read More

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http://doi.wiley.com/10.1111/pcmr.12767
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http://dx.doi.org/10.1111/pcmr.12767DOI Listing
January 2019
10 Reads

Eye-Sparing Treatment for Diffuse Invasive Conjunctival Melanoma.

Ocul Oncol Pathol 2018 Jun 1;4(4):261-266. Epub 2018 Feb 1.

Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

The management of patients with diffuse invasive conjunctival melanoma focuses on local tumor control and screening for metastasis. Despite the lack of consensus on the benefit of sentinel lymph node biopsy for these neoplasms, the information obtained by histopathology is useful for tumor staging and treatment planning. Due to the lack of evidence of survival improvement, orbital exenteration is being performed with diminishing frequency. Read More

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http://dx.doi.org/10.1159/000485978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322084PMC
June 2018
2 Reads

Single-Stage Orbital Socket Reconstruction Using the Oversized Dermis Fat Graft and the 22 mm Silicone Orbital Implant after an Extended Enucleation.

Case Rep Ophthalmol Med 2018 4;2018:8954193. Epub 2018 Dec 4.

University Eye Clinic, Faculty of Dental Medicine and Health Care Osijek, Faculty of Medicine Osijek, University Josip Juraj Strossmayer in Osijek, University Hospital "Sveti Duh", Zagreb, Croatia.

We would like to present a surgical technique of orbital socket reconstruction using oversized dermis fat graft and 22 mm silicone orbital implant in a single-stage after extended enucleation in two patients with massive local recurrence of anteriorly located choroidal melanoma previously treated with endoresection. Orbital tissues en bloc were removed leaving conjunctival lining only at the fornices. Simultaneously, the 22 mm silicone sphere was implanted deeply into the orbit and covered with the oversized dermis fat graft of 30 mm in height and 35 mm in length with 20 mm of the fat thickness. Read More

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https://www.hindawi.com/journals/criopm/2018/8954193/
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http://dx.doi.org/10.1155/2018/8954193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304640PMC
December 2018
17 Reads

Genetic Profiling of Primary Orbital Melanoma: An Analysis of 6 Cases with Clinicopathologic Correlation.

Ophthalmology 2018 Dec 31. Epub 2018 Dec 31.

Department of Oncology & Metabolism, Medical School, University of Sheffield, Sheffield, United Kingdom.

Purpose: To analyze the genetic profile of 6 cases of primary orbital melanoma with clinicopathologic correlation.

Design: Retrospective noninterventional study to analyze the genetic profile of 6 cases of primary orbital melanoma and to correlate the genetic findings with prognosis and clinicopathologic features. Inclusion criteria were patients with primary orbital melanoma with no evidence of primary eyelid skin, conjunctival, uveal, or remote melanoma at extraocular sites. Read More

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http://dx.doi.org/10.1016/j.ophtha.2018.12.047DOI Listing
December 2018

Corneal dysplastic melanosis associated with recurrent corneal erosions: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13367

Department of Ophthalmology, Seoul National University College of Medicine.

Rationale: Pigmented lesions of conjunctiva and cornea can be observed in various conditions, from the benign nevus to malignant melanoma. Pigmented acquired melanosis (PAM) is one of them, which is a neoplastic proliferation with malignant transformation potential of melanocytes. However, to our knowledge, there has been no report as to a disturbance of corneal barrier function caused by PAM. Read More

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http://dx.doi.org/10.1097/MD.0000000000013367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319972PMC
December 2018
15 Reads

Detection of mutations in SF3B1, EIF1AX and GNAQ in primary orbital melanoma by candidate gene analysis.

BMC Cancer 2018 Dec 17;18(1):1262. Epub 2018 Dec 17.

Orbital Service, Moorfields Eye Hospital, City Road, London, EC1V 2PD, UK.

Background: Ocular melanoma is a rare but often deadly malignancy that arises in the uvea (commonest primary site), conjunctiva or the orbit. Primary orbital melanoma (POM) is exceedingly rare, with approximately 60 cases reported to date. Despite recent advances in our understanding of the genetics of primary uveal and conjunctival melanomas, this information is lacking for POM. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-5190-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297940PMC
December 2018
2 Reads

Conjunctival melanoma and electrochemotherapy: preliminary results using 2D and 3D cell culture models in vitro.

Acta Ophthalmol 2018 Dec 10. Epub 2018 Dec 10.

Liverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

Purpose: To investigate the cytotoxic effect of bleomycin, mitomycin C (MMC) and Fluorouracil (5-FU) in combination with electroporation (EP) on human conjunctival melanoma (CM) and normal conjunctival cell lines using 2D and 3D cell culture systems in vitro.

Methods: Two CM (CRMM1, CRMM2) and one normal conjunctival epithelial cell line (HCjE-Gi) were treated with various EP conditions and increasing concentrations of 5-FU, MMC and bleomycin. Cell survival was assessed by MTT viability assay. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/aos.13993
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http://dx.doi.org/10.1111/aos.13993DOI Listing
December 2018
16 Reads

Expression of VEGF in human conjunctival melanoma analyzed with immunohistochemistry.

Clin Ophthalmol 2018 19;12:2363-2367. Epub 2018 Nov 19.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan,

Purpose: The aim of this study was to examine the immunolocalization of VEGF-A and CD34, a marker of endothelial cells, in human conjunctival melanoma.

Methods: This study retrospectively analyzed primary conjunctival melanoma patients who underwent surgical resection of the tumor. All excised tissues were fixed with paraformaldehyde and embedded in paraffin, which were then submitted for immunohistochemistry with anti-VEGF and CD34 antibodies. Read More

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http://dx.doi.org/10.2147/OPTH.S184193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251435PMC
November 2018
1 Read

Gallbladder Metastasis From Conjunctival Melanoma.

Clin Nucl Med 2019 Feb;44(2):e107-e109

From the Department of Nuclear Medicine, Institut Curie, PSL Research University, Paris, France.

Malignant conjunctival melanoma is a rare tumor. A 46-year-old woman with a history of locally recurrent left conjunctival melanoma was followed by F-FDG PET/CT. Four years after the local recurrence treated by orbital exenteration, the follow-up PET/CT scan showed an incidental intense FDG uptake mass infiltrating the gallbladder associated with a low uptake of an infracentimetric pulmonary nodule. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9732
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http://dx.doi.org/10.1097/RLU.0000000000002413DOI Listing
February 2019
12 Reads

Malignant melanoma of conjunctiva: Diagnosis on fine-needle aspiration cytology.

J Lab Physicians 2018 Oct-Dec;10(4):453-456

Department of Pathology, Post Graduate Institute of Medical Education and Research, Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Malignant melanoma of conjunctiva is an uncommon malignancy. The diagnosis is suspected clinically and confirmed on pathological examination. We present a case of a 63-year-old female with previous history of pigmented lesion in the right eye and subsequently diagnosed as malignant melanoma of right conjunctiva and cornea on fine-needle aspiration cytology and histopathology. Read More

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http://dx.doi.org/10.4103/JLP.JLP_43_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210837PMC
December 2018

Conjunctival melanoma.

An Bras Dermatol 2018 Nov/Dec;93(6):936-937

Medical School student, Universidade do Oeste Paulista, Presidente Prudente (SP), Brazil.

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http://dx.doi.org/10.1590/abd1806-4841.20187657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256205PMC
February 2019
1 Read

TRPM8 Activation via 3-Iodothyronamine Blunts VEGF-Induced Transactivation of TRPV1 in Human Uveal Melanoma Cells.

Front Pharmacol 2018 13;9:1234. Epub 2018 Nov 13.

Klinik für Augenheilkunde, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Berlin Institute of Health, Humboldt-Universität zu Berlin, Berlin, Germany.

In human uveal melanoma (UM), tumor enlargement is associated with increases in aqueous humor vascular endothelial growth factor-A (VEGF-A) content that induce neovascularization. 3-Iodothyronamine (3-TAM), an endogenous thyroid hormone metabolite, activates TRP melastatin 8 (TRPM8), which blunts TRP vanilloid 1 (TRPV1) activation by capsaicin (CAP) in human corneal, conjunctival epithelial cells, and stromal cells. We compare here the effects of TRPM8 activation on VEGF-induced transactivation of TRPV1 in an UM cell line (92. Read More

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https://www.frontiersin.org/article/10.3389/fphar.2018.01234
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http://dx.doi.org/10.3389/fphar.2018.01234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243059PMC
November 2018
4 Reads

Non-invasive dynamic assessment of conjunctival melanomas by photoacoustic imaging.

Exp Eye Res 2019 02 14;179:157-167. Epub 2018 Nov 14.

Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Ophthalmology and Vision Sciences, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Physics, Faculty of Science, Ryerson University, Toronto, Ontario, Canada; Faculty of Engineering and Architectural Science, Ryerson University, Toronto, Ontario, Canada; Institute of Biomedical Engineering, Science and Technology (iBEST), St. Michael's Hospital, Ryerson University, Toronto, Ontario, Canada. Electronic address:

This study describes non-invasive photoacoustic imaging to detect and monitor the growth of conjunctival melanomas in vivo. Conjunctival melanomas were induced by injection of melanotic B16F10 cells into the subconjunctival space in syngeneic albino C57BL/6 mice. Non-invasive in vivo photoacoustic tomography was performed before, and after tumor induction up to 2 weeks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144835183060
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http://dx.doi.org/10.1016/j.exer.2018.11.014DOI Listing
February 2019
18 Reads

Prognostic factors and incidence of primary mucosal melanoma: a population-based study in France.

Eur J Dermatol 2018 Oct;28(5):654-660

Department of Dermatology.

Few population-based studies on the incidence and prognosis of primary mucosal melanoma (PMM) are available. The first objective was to evaluate disease-specific survival of PMM, overall and according to specific locations, and to identify prognostic factors. The second objective was to assess the global incidence of PMM compared to cutaneous melanoma and to specify the relative frequency of each affected location. Read More

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http://dx.doi.org/10.1684/ejd.2018.3398DOI Listing
October 2018
3 Reads

Immunotherapy With Programmed Cell Death 1 Inhibitors for 5 Patients With Conjunctival Melanoma.

JAMA Ophthalmol 2018 Nov;136(11):1236-1241

Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston.

Importance: Conjunctival melanoma has the potential for regional lymphatic and distant metastasis. There is an urgent need for effective treatment for patients with metastatic or locally advanced conjunctival melanoma.

Objective: To describe the use of immune checkpoint inhibitors for the treatment of conjunctival melanoma in 5 adult patients. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2018.3488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248169PMC
November 2018
17 Reads

Conjunctival Dehiscence and Scleral Necrosis following Iodine-125 Plaque Brachytherapy for Uveal Melanoma: A Report of 3 Cases.

Ocul Oncol Pathol 2018 Sep 13;4(5):291-296. Epub 2018 Feb 13.

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA.

Background/aims: Plaque brachytherapy is currently the most common treatment for uveal melanoma and has many known potential complications. Here we present 3 cases of early conjunctival and scleral necrosis following iodine-125 plaque.

Methods: This study was conducted as a retrospective case series. Read More

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https://www.karger.com/Article/FullText/481858
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http://dx.doi.org/10.1159/000481858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167656PMC
September 2018
10 Reads

The Patient's Experience of Ocular Melanoma in the US: A Survey of the Ocular Melanoma Foundation.

Ocul Oncol Pathol 2018 Sep 8;4(5):280-290. Epub 2018 Feb 8.

Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.

Background: Ocular melanomas threaten patients with early death, visual handicap, and loss of the eye. The aims of this study were to identify aspects of care that patients with ocular melanoma considered most important and to determine whether patients felt their needs had been adequately addressed.

Methods: A cross-sectional study including US ocular melanoma patients and their caregivers. Read More

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http://dx.doi.org/10.1159/000485189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170915PMC
September 2018

Orbital Cellulitis and Secondary Angle Closure: A Rare Presentation of Choroidal Melanoma.

Ocul Oncol Pathol 2018 Sep 26;4(2):130-133. Epub 2017 Sep 26.

Save Sight Institute, Sydney, NSW, Australia.

We describe a case of choroidal melanoma initially presenting with orbital cellulitis, fulminant conjunctival swelling, and secondary angle closure. Despite treatment with intravenous antibiotics, the patient's condition did not improve. With further investigations including ultrasound scan and magnetic resonance imaging, a high-density lesion was found within the globe. Read More

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https://www.karger.com/Article/FullText/477546
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http://dx.doi.org/10.1159/000477546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167683PMC
September 2018
13 Reads

Conjunctival Metastasis of a Cutaneous Melanoma.

Ocul Oncol Pathol 2018 Sep 1;4(2):107-111. Epub 2017 Sep 1.

Department of Ophthalmology, Leiden University Medical Centre, Leiden, The Netherlands.

Purpose: To report a patient who presented with a conjunctival tumour as a first sign of distant metastasis of cutaneous melanoma. The patient was treated successfully with BRAF/MEK-inhibitors and anti-PD-1 antibodies.

Methods: Clinical and histopathological examination of the conjunctival lesion. Read More

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https://www.karger.com/Article/FullText/479114
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http://dx.doi.org/10.1159/000479114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167684PMC
September 2018
19 Reads

Pigmented Conjunctival Lesions as Presenting Signs of Vaginal Melanoma.

Ocul Oncol Pathol 2018 Sep 23;4(2):79-81. Epub 2017 Aug 23.

Ophthalmic Plastic Surgery, Lions Eye Institute-Albany Medical Center, Slingerlands, NY, USA.

A 43-year-old woman was referred to an oculoplastic surgeon for the evaluation of 2 small pigmented lesions in the tarsal conjunctiva. She underwent a biopsy of the lesions, both of which were found to be consistent with metastatic melanoma. Follow-up with the patient revealed that she had been hospitalized for balance issues and headaches. Read More

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http://dx.doi.org/10.1159/000478278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167657PMC
September 2018
8 Reads

Super-Thick Amniotic Membrane Graft for Ocular Surface Reconstruction.

Am J Ophthalmol 2019 Feb 9;198:45-53. Epub 2018 Oct 9.

The New York Eye Cancer Center, New York, New York, USA.

Purpose: The purpose of this study was to evaluate super-thick amniotic membrane grafts (ST-AMGs) for ocular surface reconstruction.

Design: Retrospective, interventional case series.

Methods: This was a single-center study of clinical practice that included select patients with typically large ocular surface abnormalities that required reconstruction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183057
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http://dx.doi.org/10.1016/j.ajo.2018.09.035DOI Listing
February 2019
5 Reads

Reconstruction of the Lacrimal Excretory System in the Medial Canthal Region.

Plast Reconstr Surg Glob Open 2018 Jun 19;6(6):e1795. Epub 2018 Jun 19.

Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Osaka City University, Osaka, Japan.

The resection of malignant tumors in medial canthal region may lead to full-thickness defects including medial canthal ligament and lacrimal duct. There had been reports on various reconstructive methods, but none of those methods succeeded in lacrimal reconstruction with functional lacrimal excretory system. We experienced a case of conjunctival malignant melanoma at the lacrimal caruncle and performed new method of the reconstruction for full-thickness defects of the medial canthal region with the maintenance of the lacrimal drainage function. Read More

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http://dx.doi.org/10.1097/GOX.0000000000001795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157939PMC
June 2018
42 Reads

Cancers of the eye.

Cancer Metastasis Rev 2018 12;37(4):677-690

The New York Eye Cancer Center, Suite 5B, 115 East 61st Street, New York, NY, 10065, USA.

Ocular cancers are unique among the diseases of the eye, threatening both vision and life. In most cases, the diagnosis can be made utilizing a careful clinical history and specialized ocular examination. Eye cancer diagnosis relies heavily on imaging techniques such as high-frequency ultrasound, fluorescein angiography, anterior and posterior segment optical coherence tomography, computed tomography (CT), and magnetic resonance imaging (MRI). Read More

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http://link.springer.com/10.1007/s10555-018-9762-9
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http://dx.doi.org/10.1007/s10555-018-9762-9DOI Listing
December 2018
24 Reads

Dermoscopy for the Diagnosis of Conjunctival Lesions.

Dermatol Clin 2018 Oct 16;36(4):439-449. Epub 2018 Aug 16.

Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria Alle Scotte Hospital, Viale Bracci 16, Siena 53100, Italy.

This article describes the present literature on dermoscopy of conjunctiva and shows the results of a dermoscopy study of 147 conjunctival tumors. Melanomas were characterized by a heavy pigmentation, irregular dots, and a higher prevalence of gray color compared with nevi. Squamous cell carcinomas had peculiar hairpin and glomerular vessels. Read More

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http://dx.doi.org/10.1016/j.det.2018.05.011DOI Listing
October 2018
31 Reads

Coned Radial Forearm Free Flap for Improved Retention of Orbital Prosthesis following Orbital Exenteration.

Plast Reconstr Surg 2018 11;142(5):818e-819e

Royal Prince Alfred Hospital Westmead Clinical School, Westmead and, Institute of Academic Surgery, Royal Prince Alfred Hospital, University of Sydney Institute of Academic Surgery, Royal Prince Alfred Hospital, University of Sydney and Department of Head and Neck Surgery, Chris O'Brien Lifehouse Cancer Centre Institute of Academic Surgery, Royal Prince Alfred Hospital, University of Sydney, Department of Head and Neck Surgery, Chris O'Brien Lifehouse Cancer Centre, and Department of Plastic Surgery, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

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http://dx.doi.org/10.1097/PRS.0000000000004910DOI Listing
November 2018
2 Reads

Inflammatory juvenile compound nevi: A melanoma is not all that it appears to be.

Arch Soc Esp Oftalmol 2019 Feb 8;94(2):90-94. Epub 2018 Aug 8.

Servicio de Córnea y Cirugía Refractiva, Asociación Para Evitar la Ceguera en México, Ciudad de México, México.

An 11 year-old girl presented with a recent growth pigmented conjuntival lesion in the bulbar conjunctiva of left eye. Due to the the biomicroscopic and ultrasound findings, an excisional biopsy was performed on the lesion using the «no touch» technique, as well as cryo-coagulation of surgical margins. Histopathological examination revealed an inflammatory compound nevus. Read More

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http://dx.doi.org/10.1016/j.oftal.2018.06.022DOI Listing
February 2019
3 Reads

Resolution of conjunctival melanoma with topical interferon alpha 2b in a patient with mitomycin C intolerance.

Arch Soc Esp Oftalmol 2018 Nov 30;93(11):558-561. Epub 2018 Jul 30.

Unidad de Oculoplástica, Hospital General, Granollers, España.

Objective: To describe the clinical and histological resolution of a case of an inexcisable conjunctival melanoma using topical interferon alpha 2b (INFα2b) in a patient with mitomycin C (MMC) intolerance.

Case Report: Conjunctival melanoma is a rare, but potentially sight- and life-threatening, tumour. In cases of multiple lesions, or when surgical excision is not possible, topical combination chemotherapy with MMC and INFα2b has been described as first line therapy. Read More

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http://dx.doi.org/10.1016/j.oftal.2018.06.008DOI Listing
November 2018
3 Reads

Conjunctival melanoma in a child: A clinicopathological report.

Saudi J Ophthalmol 2018 Apr-Jun;32(2):156-159. Epub 2017 Sep 28.

Department of Ophthalmology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

We report a case of a 16 years old Asian Indian boy who presented with a large brownish lesion measuring 20 × 12 mm on the temporal conjunctive in his right eye. Anterior segment optical coherence topography revealed cystic spaces without scleral involvement. The patient underwent conjunctival excisional biopsy using "no touch" technique with double freeze-thaw cryotherapy to underside of the adjacent conjunctival margins. Read More

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http://dx.doi.org/10.1016/j.sjopt.2017.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010591PMC
September 2017
35 Reads

Conjunctival invasive poorly differentiated squamous cell carcinoma in a 91-year-old female patient.

Rom J Morphol Embryol 2018 ;59(1):375-380

Department of Surgery (Dental and Oro-Maxillo-Facial Surgery), "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania;

The invasive conjunctival squamous cell carcinoma (SCC) of the eyeball is a malignant tumor that invades only the conjunctiva and rarely the eyeball and the tissue of the orbit. We presented the clinical case of a 91-year-old patient, hospitalized at the 2nd Ophthalmology Clinic of the "Prof. Dr. Read More

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October 2018
4 Reads

Conjunctival melanocytic tumors in children - a challenge in diagnosis and treatment.

Rom J Morphol Embryol 2018 ;59(1):317-322

Discipline of Ophthalmology, Department of Surgery II, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania;

Conjunctival melanocytic lesions are very diverse pigmented tumors that include benign, premalignant and malignant tumors. The aim of this article is to highlight the clinical and histopathological aspects of conjunctival melanocytic tumors at children. This study is a retrospective case series study of three patients selected from fifteen cases with melanocytic conjunctival tumors who were operated in the Department of Ophthalmology, "St. Read More

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October 2018
18 Reads

Conjunctival Melanoma Metastasis to the Contralateral Orbit.

J Craniofac Surg 2018 Nov;29(8):2128-2130

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine.

Background: Malignant melanoma predominantly occurs in whites, and is potentially fatal. Distant metastases often occur in lung, liver, brain, and could occur without prior regional disease. Conjunctival melanoma metastasis to contralateral orbit has never been reported. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004673DOI Listing
November 2018
6 Reads

[Focus on clinical and pathological management of conjunctival melanocytic tumors].

Ann Pathol 2018 Jun 24;38(3):153-163. Epub 2018 May 24.

Laboratoire de pathologie clinique et expérimentale, pavillon J, hôpital Pasteur, CHU de Nice, 30, voie Romaine, CS 51069, 06001 Nice cedex 1, France; Institute of research on cancer and aging de Nice (IRCAN), Inserm U1081/CNRS UMR7284, UFR de médecine, 28, avenue Valombrose, 06107 Nice cedex 2, France; FHU OncoAge Nice, 30, avenue de la voie Romaine, CS 51069, 06001 Nice cedex 1, France.

Conjunctival-pigmented tumors are rare, but they are one of the most commonly encountered by the pathologist working with the department of ophthalmology. Nevus and melanoma can be encountered and have some histological difference compared to their cutaneous counterpart. Primary acquired melanosis (PAM) is a conjunctival specific entity. Read More

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http://dx.doi.org/10.1016/j.annpat.2018.03.006DOI Listing
June 2018
5 Reads

Conjunctival Melanoma - Epidemiological Trends and Features.

Pathol Oncol Res 2018 Oct 25;24(4):787-796. Epub 2018 May 25.

Psychiatric Hospital Sveti Ivan, Zagreb, Croatia.

Conjunctival melanoma is a rare but sight and life threatening malignancy. It accounts for 2%-5% of all ocular tumours and 5%-7% of all ocular melanomas with an incidence of 0.2-0. Read More

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http://dx.doi.org/10.1007/s12253-018-0419-3DOI Listing
October 2018
6 Reads
1.810 Impact Factor

Possible dissemination of conjunctival melanoma along tear flow path.

Am J Ophthalmol Case Rep 2018 Jun 23;10:122-123. Epub 2018 Feb 23.

Department of Pathology, National Hospital Organization, Nagoya Medical Center, Japan.

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http://dx.doi.org/10.1016/j.ajoc.2018.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956803PMC
June 2018
1 Read

Outcomes after surgical resection of lower eyelid tumors and reconstruction using a nasal chondromucosal graft and an upper eyelid myocutaneous flap.

J Fr Ophtalmol 2018 May 16;41(5):412-420. Epub 2018 May 16.

Institut Curie, 26, rue d'Ulm, 75248 Paris cedex 05, France.

Introduction: Surgical excision of large malignant lower eyelid tumors may cause important full-thickness eyelid defects. The reconstruction of such defects must restore the physiologic function of the eyelid and also re-establish an acceptable aesthetic result.

Materials And Methods: We report the outcomes of full-thickness excision of tumors extending over half of the horizontal lid length, followed by reconstruction using a nasal chondromucosal graft (coming from the ipsilateral ala of the nose) and an upper eyelid myocutaneous flap. Read More

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http://dx.doi.org/10.1016/j.jfo.2017.10.008DOI Listing
May 2018
5 Reads

Lack of tumour pigmentation in conjunctival melanoma is associated with light iris colour and worse prognosis.

Br J Ophthalmol 2019 Mar 18;103(3):332-337. Epub 2018 May 18.

Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands

Aim: To investigate whether differences in iris colour, skin colour and tumour pigmentation are related to clinical outcome in conjunctival melanoma.

Methods: Data of 70 patients with conjunctival melanoma from the Leiden University Medical Center (Leiden, The Netherlands) and 374 patients from the Wills Eye Hospital (Philadephia, USA) were reviewed. The relation between iris colour, skin colour and tumour pigmentation versus clinical parameters and outcome was investigated using univariate and multivariate regression analyses. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312018DOI Listing
March 2019
5 Reads