1,512 results match your criteria Melanoma Conjunctival


Clinical and immunohistopathological study of conjunctival melanocytic lesions in pediatric and adolescent patients. A case series.

Rom J Morphol Embryol 2021 Oct-Dec;62(4):907-915

Discipline of Ophthalmology, Department of Surgery II, Discipline of Anatomy and Embryology, Department of Morphofunctional Sciences I, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania;

Background: Conjunctival pigmented neoplasia can be benign, premalignant or malignant tumors. Our study aims to establish the epidemiological, gross morphological and immunohistopathological features of the conjunctival pigmented lesions in pediatric and adolescent patients (<18 years), to establish an accurate diagnosis.

Patients, Material And Methods: This is a retrospective case series study conducted within two Ophthalmology Clinics from Iaşi, Romania, on seven pediatric and adolescent patients. Read More

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BRAF and NRAS prognostic values in conjunctival melanoma: analysis and literature review.

Arq Bras Oftalmol 2022 May 9. Epub 2022 May 9.

Department of Ophthalmology, University Clinical Hospital of Valladolid, Spain.

Purpose: Conjunctival melanoma is a rare and aggressive tumor with a propensity for regional and distant metastases. This study aimed to analyze BRAF/NRAS markers in conjunctival melanoma and their relationship with tumor recurrences and patient prognosis.

Methods: This retrospective, observational, single-center study included consecutive patients with an anatomopathological diagnosis of conjunctival melanoma, registered between January 1992 and December 2019. Read More

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Xeroderma pigmentosum: an updated review.

Drugs Context 2022 25;11. Epub 2022 Apr 25.

Department of Paediatrics, Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong.

Background: Early recognition of xeroderma pigmentosum is important to minimize the complications arising from the harmful effects of exposure to ultraviolet radiation. This narrative review aims to familiarize physicians with the clinical features, diagnosis and management of xeroderma pigmentosum.

Methods: A search was conducted in December 2021 in PubMed Clinical Queries using the key term "xeroderma pigmentosum". Read More

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Clinicopathologic features and survival outcomes of ocular melanoma: a series of 31 cases from a tertiary university hospital.

J Pathol Transl Med 2022 May 3. Epub 2022 May 3.

Department of Pathology, Faculty of Medicine, Gazi University, Ankara, Turkey.

Background: We aimed to determine the effect of clinicopathologic features on overall survival among Caucasian ocular melanoma patients in the Central Anatolia region of Turkey.

Materials And Methods: This single-center study included conjunctival (n = 12) and uveal (n = 19) melanoma patients diagnosed between January 2008 and March 2020. Clinicopathologic features and outcomes were reviewed retrospectively. Read More

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Conjunctival malignant melanoma treated successfully with BRAF inhibitor: encorafenib plus binimetinib.

Dermatol Online J 2022 01 15;28(1). Epub 2022 Jan 15.

Department of Dermatology, Iwate Medical University School of Medicine, Yahaba-cho Iwate, Japan.

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January 2022

Annulus-shaped I-125 plaque brachytherapy for conjunctival melanoma.

Am J Ophthalmol Case Rep 2022 Jun 18;26:101512. Epub 2022 Apr 18.

Tennessee Retina, Nashville, TN, USA.

Purpose: To report successful ring-shaped iodine-125 plaque brachytherapy for conjunctival melanoma.

Observations: Eye Physics (EP) plaque brachytherapy, designed with Plaque Simulator software, proved to be an effective treatment modality with some corneal irritation and no recurrence at 12-months post radiation.

Conclusion And Importance: Management of conjunctival melanoma is complicated by the lack of gold standard adjuvant treatments. Read More

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Blue nevi of the palpebral conjunctiva: report of 2 cases and review of literature.

Orbit 2022 Apr 28:1-8. Epub 2022 Apr 28.

Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Purpose: To describe two patients with blue nevi of the palpebral conjunctiva and to review the existing literature on common and cellular blue nevi of the conjunctiva.

Methods: Report of two cases and literature review.

Results: We present two cases of blue nevi in the palpebral conjunctiva: an atypical cellular blue nevus of the left upper eyelid and a common blue nevus around the lacrimal punctum of the left lower eyelid. Read More

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PRAME Expression in Junctional Melanocytic Proliferations of the Conjunctiva: A Potential Biomarker for Primary Acquired Melanosis/Conjunctival Melanocytic Intraepithelial Lesions.

Am J Dermatopathol 2022 Apr 11. Epub 2022 Apr 11.

Departments of Pathology, and.

Abstract: Conjunctival melanocytic proliferations are diagnostically challenging, often complicated by small specimen size, and are separated into 3 broad categories. The first group includes benign nevi and primary acquired melanosis (PAM) without atypia. The second group includes junctional melanocytic proliferations with a risk of progression to invasive melanoma (PAM with atypia). Read More

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Clinical profile of melanocytic lesions of the ocular surface in a Hispanic population.

Int Ophthalmol 2022 Apr 19. Epub 2022 Apr 19.

Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Batallon de San Patricio 112, 1st Floor. Real de San Agustin, 66278, Monterrey, NL, Mexico.

Purpose: To determine the prevalence, clinical characteristics, and demographic factors of melanocytic lesions of the ocular surface, such as racial melanosis, primarily acquired melanosis, conjunctival nevus, and conjunctival melanoma in a Hispanic population.

Materials And Methods: A cross-sectional and observational study was undertaken in a tertiary referral ophthalmological center in northern Mexico from December 2020 to April 2021. All patients attending an ophthalmology specialty clinic were screened during their first visit in order to detect melanocytic lesions of the ocular surface. Read More

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Single Time Frame Overview of the Genetic Changes in Conjunctival Melanoma from Intraepithelial Disease to Invasive Melanoma: A Study of 4 Exenteration Specimens Illustrating the Potential Role of Cyclin D1.

Ocul Oncol Pathol 2022 Feb 17;8(1):52-63. Epub 2021 Nov 17.

Department of Biopathologie, Centre Leon Berard, Lyon, France.

Introduction: Despite advances in the understanding of the molecular pathogenesis of cutaneous melanoma, relatively little is known about the genetic changes that occur in the progression of conjunctival melanocytic intraepithelial lesions to invasive conjunctival melanoma.

Methods: We exposed 4 exenteration specimens that each contained varying grades of intraepithelial conjunctival melanocytic neoplasia and invasive neoplasia to a combination of various techniques, including array comparative genomic hybridization (aCGH), ribonucleic acid sequencing (RNA-seq), fluorescence in situ hybridization (FISH), and immunohistochemistry.

Results: Three out of 4 of the invasive melanomas showed gains in 11q13 (CCND1 locus) by aCGH. Read More

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February 2022

Incidence and survival of ocular melanoma in National Cancer Registry of Poland in 2010-2017.

Adv Clin Exp Med 2022 Mar 29. Epub 2022 Mar 29.

Department of Analyses and Strategies, Ministry of Health, Warszawa, Poland.

Background: Oncology trends are based on data coming from different countries and ocular melanoma is the most common primary eye cancer in adults.

Objectives: To investigate the incidence and characteristics of ocular melanoma in the overall population of Poland.

Material And Methods: The retrospective survey of both the National Cancer Registry (NCR) and National Health Fund (NHF) databases was performed to identify all ocular melanoma cases in Poland in 2010-2017. Read More

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The Prognostic Relevance of PMCA4 Expression in Melanoma: Gender Specificity and Implications for Immune Checkpoint Inhibition.

Int J Mol Sci 2022 Mar 19;23(6). Epub 2022 Mar 19.

Department of Thoracic Surgery, University Medicine Essen-Ruhrlandklinik, 45239 Essen, Germany.

PMCA4 is a critical regulator of Ca homeostasis in mammalian cells. While its biological and prognostic relevance in several cancer types has already been demonstrated, only preclinical investigations suggested a metastasis suppressor function in melanoma. Therefore, we studied the expression pattern of PMCA4 in human skin, nevus, as well as in primary and metastatic melanoma using immunohistochemistry. Read More

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A Case of Non-Irradiated Balloon Cell Melanoma of the Choroid: Expanding the Morphological Spectrum of Primary Uveal Melanomas.

Diagnostics (Basel) 2022 Mar 5;12(3). Epub 2022 Mar 5.

Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", Anatomic Pathology, University of Catania, 95123 Catania, Italy.

Uveal melanoma (UM) is the most common primary intraocular tumor in adults and usually has a very poor prognosis. Histologically, UMs have been classified in epithelioid cell type, spindle cell type, and mixed cell type. Balloon cells are large pale cells that contain small, hyperchromatic, central nuclei with vesiculated, clear, and lipid-rich cytoplasm. Read More

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Identification of New Vulnerabilities in Conjunctival Melanoma Using Image-Based High Content Drug Screening.

Cancers (Basel) 2022 Mar 19;14(6). Epub 2022 Mar 19.

Jules-Gonin Eye Hospital, University of Lausanne, 1004 Lausanne, Switzerland.

Recent evidence suggests that numerous similarities exist between the genomic landscapes of both conjunctival and cutaneous melanoma. Since alterations of several components of the MAP kinases, PI3K/mTOR, and cell cycle pathways have been reported in conjunctival melanoma, we decided to assess the sensitivity of conjunctival melanoma to targeted inhibition mostly of kinase inhibitors. A high content drug screening assay based on automated fluorescence microscopy was performed in three conjunctival melanoma cell lines with different genomic backgrounds with 489 kinase inhibitors and 53 other inhibitors. Read More

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Granuloma of graphite foreign body in conjunctiva simulates melanoma: a case report and literature review.

Int J Ophthalmol 2022 18;15(3):515-517. Epub 2022 Mar 18.

Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.

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Melanoma of the Palpebral Conjunctiva and Eyelid.

N Engl J Med 2022 Mar 19;386(12):e28. Epub 2022 Mar 19.

Xi'an No.3 Hospital, Xi'an, China

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Genetic characterization of advanced conjunctival melanoma and response to systemic treatment.

Eur J Cancer 2022 05 10;166:60-72. Epub 2022 Mar 10.

Department of Dermatology, Venereology and Allergology, University Hospital Essen, Essen, Germany; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen and German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

Background: Conjunctival melanoma is a rare type of ocular melanoma, which is prone to local recurrence and metastasis and can lead to patient death. Novel therapeutic strategies have revolutionized cutaneous melanoma management. The efficacy of these therapies in conjunctival melanoma, however, has not been evaluated in larger patient cohorts. Read More

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Use of interferon alpha 2b to manage conjunctival primary acquired melanosis and conjunctival melanoma.

Surv Ophthalmol 2022 Mar 9. Epub 2022 Mar 9.

Department of Ophthalmology, University Hospital Arnau de Vilanova, Lleida, Spain; School of Medicine, University of Lleida, Lleida, Spain; Biomedical Research Institute of Lleida, University of Lleida, Lleida, Spain. Electronic address:

Primary acquired melanosis (PAM) is acquired conjunctival pigmentation that can give rise to conjunctival melanoma (CM), a malignant tumor of the bulbar and palpebral conjunctiva or the caruncle. Surgical excision is the treatment of choice for this neoplasm. Topical chemotherapy is also used for patients with PAM with atypia or CM and, in patients with recurrent or extensive disease, this may be an important option. Read More

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Diagnosis of the origin of an epibulbar melanocytic tumor with molecular genomics.

Ophthalmic Genet 2022 Mar 8:1-4. Epub 2022 Mar 8.

Ocular Oncology Service, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

Background: Uveal melanoma (UM) and conjunctival melanoma (CM) are distinct entities with different etiologies and genetic background. We present a case of an atypical subconjunctival melanoma arising from a blue nevus.

Patients And Methods: A 61-year-old female presented with a partially melanocytic epibulbar mass with surrounding episcleral pigmented spots. Read More

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Insidious ocular surface lesion in an 81-year-old woman.

BMJ Case Rep 2022 Mar 4;15(3). Epub 2022 Mar 4.

Department of Ophthalmology, Galway University Hospitals, Galway, Ireland.

Ocular surface melanoma (OSM) is rare. An 81-year-old Caucasian woman presented with a 4-month history of right eye pain and reduced vision. Histopathological examination of the excisional biopsy identified invasive amelanotic melanoma of the conjunctiva expressing Melan A and SOX10. Read More

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American Joint Committee on Cancer Tumor Staging System Predicts the Outcome and Metastasis Pattern in Conjunctival Melanoma.

Ophthalmology 2022 Jul 1;129(7):771-780. Epub 2022 Mar 1.

Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China. Electronic address:

Purpose: To assess the predictive value of the tumor staging system in the AJCC Cancer Staging Manual, Eighth Edition, and histologic features for outcomes and metastasis patterns in conjunctival melanoma (CM).

Design: Retrospective, single-center cohort study.

Participants: Eighty-three patients with CM were treated at Shanghai Ninth People's Hospital between 2000 and 2021. Read More

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Scleral complications of plaque brachytherapy for pterygium and for uveal melanoma.

Clin Exp Ophthalmol 2022 May 18;50(4):465-466. Epub 2022 Mar 18.

Department of Ophthalmology, Prince of Wales Hospital, Sydney, New South Wales, Australia.

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Immunohistochemical and mutational status of telomerase reverse transcriptase in conjunctival squamous cell carcinoma.

Indian J Ophthalmol 2022 Mar;70(3):971-975

Oculo Service, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: Mutations in human telomerase reverse transcriptase (TERT) are associated with increased telomerase activity in cutaneous melanomas. Conjunctival squamous cell carcinoma, also referred to as ocular surface squamous cell carcinoma, is cancer on the surface of the eye. Recent studies have identified UV signat`ure mutations in TERT promoters in ocular melanoma and ocular surface squamous neoplasia. Read More

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Clinicopathological Analysis and Surgical Outcome of Eyelid Malignancies: A Study of 332 Cases.

J Skin Cancer 2022 18;2022:4075668. Epub 2022 Feb 18.

Department of Pathology, Northern International Medical College, Dhaka, Bangladesh.

Background: Eyelid tumours are common in our ophthalmic practice. Malignancy cases account only for one-fourth of all eyelid tumours. The most aggressive eyelid malignancy is sebaceous gland carcinoma, but its occurrences are rare in western countries. Read More

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February 2022

Mutational Characteristics of Primary Mucosal Melanoma: A Systematic Review.

Mol Diagn Ther 2022 03 23;26(2):189-202. Epub 2022 Feb 23.

Université de Reims Champagne-Ardenne, EA 7509: Immune Dysregulation and Tissue Remodelling in Cancer, Autoimmune and Inflammatory Diseases, Reims, France.

Background: Primary mucosal melanomas (PMMs) are rare and clinically heterogeneous, including head and neck (HNMs), vulvovaginal (VVMs), conjunctival (CjMs), anorectal (ARMs) and penile (PMs) melanomas. While the prognosis of advanced cutaneous melanoma has noticeably improved using treatments with immune checkpoint inhibitors (ICIs) and molecules targeting BRAF and MEK, few advances have been made for PMMs because of their poorer response to ICIs and their different genetic profile. This prompted us to conduct a systematic review of molecular studies of PMMs to clarify their pathogenesis and potential therapeutic targets. Read More

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New Therapeutic Approaches for Conjunctival Melanoma-What We Know So Far and Where Therapy Is Potentially Heading: Focus on Lymphatic Vessels and Dendritic Cells.

Int J Mol Sci 2022 Jan 27;23(3). Epub 2022 Jan 27.

Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.

Conjunctival melanoma (CM) accounts for 5% of all ocular melanomas and arises from malignantly transformed melanocytes in the conjunctival epithelium. Current therapies using surgical excision in combination with chemo- or cryotherapy still have high rates for recurrences and metastatic disease. Lately, novel signal transduction-targeted and immune checkpoint inhibitors like cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitors, programmed cell death protein-1 (PD-1) receptor inhibitors, BRAF- or MEK-inhibitors for systemic treatment of melanoma have improved the outcome even for unresectable cutaneous melanoma, improving patient survival dramatically. Read More

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January 2022

Modified procedure of anterior orbital exenteration enables eye socket reconstruction: A retrospective cohort study.

Medicine (Baltimore) 2022 Jan;101(4):e28698

Department of Ophthalmology, Fudan Eye & ENT Hospital, Shanghai, China.

Abstract: The conventional procedure of anterior orbital exenteration is unfavorable for eye socket reconstruction, whereas a modified procedure enables socket reconstruction and prosthesis fitting. Our study aims to compare the cosmetic outcomes between these 2 surgical techniques.We retrospectively recruited patients treated with modified or conventional exenteration during January 2015 to May 2021 in our hospital. Read More

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January 2022