1,453 results match your criteria Melanoma Conjunctival

Case of Rapidly Expanding Conjunctival Malignant Melanoma Initially from Primary Acquired Melanosis Diagnosed 14 Years Earlier.

Int Med Case Rep J 2021 28;14:361-364. Epub 2021 May 28.

Department of Ophthalmology, Nara Medical University, Nara, Japan.

Primary acquired melanosis (PAM) of the conjunctiva is a potentially serious melanocytic lesion that can lead to the development of a melanoma. A 60-year-old woman noticed pigmentation of the conjunctiva of her left eye for more than 10 years. She underwent excisional biopsy combined with cryotherapy and was diagnosed with PAM without atypia by intraoperative consultation. Read More

View Article and Full-Text PDF

PRAME Immunohistochemistry is Useful in the Evaluation of Conjunctival Melanomas, Nevi, and Primary Acquired Melanosis.

J Cutan Pathol 2021 Jun 4. Epub 2021 Jun 4.

Department of Surgery, Section of Ophthalmology, Geisel School of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Background: Many dermatopathologists find conjunctival melanocytic proliferations challenging because they are rare relative to their cutaneous counterparts and have nuanced morphology and nomenclature. PRAME immunohistochemistry has been widely adopted for distinguishing cutaneous nevi from melanoma, but limited data exist assessing its utility in evaluating conjunctival specimens. In particular, it is uncertain whether it can predict the risk of melanoma progression in primary acquired melanosis (PAM). Read More

View Article and Full-Text PDF

Diagnostic Algorithm for Conjunctival Melanocytic Lesions.

Anticancer Res 2021 Jun;41(6):3161-3167

Department of Ophthalmology and Ocular Oncology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland;

Background/aim: This study aimed to develop an algorithm allowing the differentiation between conjunctival melanoma and other melanocytic infiltrations of the conjunctiva, on the basis of a dermatoscopic examination.

Patients And Methods: A total of 160 conjunctival pigmented lesions were studied (40 melanomas and 120 non-melanoma conjunctival infiltrations). The clinical characteristics of the tumours were assessed with the use of dermatoscopic characteristics as described by Kittler, and with taking into consideration the typical characteristics of conjunctival lesions. Read More

View Article and Full-Text PDF

Molecular Genetics of Conjunctival Melanoma and Prognostic Value of Promoter Mutation Analysis.

Int J Mol Sci 2021 May 28;22(11). Epub 2021 May 28.

Department of Pathology, Section Ophthalmic Pathology, Erasmus MC University Medical Center, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.

The aim of this study was exploration of the genetic background of conjunctival melanoma (CM) and correlation with recurrent and metastatic disease. Twenty-eight CM from the Rotterdam Ocular Melanoma Study group were collected and DNA was isolated from the formalin-fixed paraffin embedded tissue. Targeted next-generation sequencing was performed using a panel covering , , , , , , , , , and genes. Read More

View Article and Full-Text PDF

Conjunctival melanoma: New insights in tumour genetics and immunology, leading to new therapeutic options.

Prog Retin Eye Res 2021 May 17:100971. Epub 2021 May 17.

Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

Recent developments in oncology have led to a better molecular and cellular understanding of cancer, and the introduction of novel therapies. Conjunctival melanoma (CoM) is a rare but potentially devastating disease. A better understanding of CoM, leading to the development of novel therapies, is urgently needed. Read More

View Article and Full-Text PDF

Incidence and trends of ophthalmic cancer in Singapore: Data from Singapore Cancer Registry.

Ann Acad Med Singap 2021 04;50(4):297-305

Department of Ophthalmology, National University Hospital, Singapore.

Introduction: Limited data are available on the incidence of primary ophthalmic cancers worldwide. We describe the incidence and trends of primary ophthalmic cancers in Singapore.

Methods: Data on ophthalmic cancers diagnosed in Singapore from 1996 to 2016 were retrieved from the Singapore Cancer Registry for analysis. Read More

View Article and Full-Text PDF

The role of imaging technologies for ocular surface tumors.

Curr Opin Ophthalmol 2021 07;32(4):369-378

Bascom Palmer Eye Institute, Department of Ophthalmology University of Miami, Miami, Florida, USA.

Purpose Of Review: This review will discuss the utility of high-resolution anterior segment optical coherence tomography (HR-OCT), in-vivo confocal microscopy (IVCM) and ultrasound biomicroscopy (UBM) in characterizing and diagnosing various ocular surface tumors, namely ocular surface squamous neoplasia (OSSN), conjunctival lymphoma and conjunctival melanoma. The strengths and limitations of each imaging modality will be discussed along with the characteristics findings of each lesion on each imaging platform.

Recent Findings: HR-OCT can consistently be utilized in the clinic setting to distinguish between epithelial ocular surface tumors such as OSSN as compared with subepithelial tumors such as conjunctival lymphoma and conjunctival melanoma given their distinctive findings. Read More

View Article and Full-Text PDF

Clinical and Histopathological Features of Corneal Primary Acquired Melanosis and Melanoma.

Ocul Oncol Pathol 2021 Mar 21;7(2):103-107. Epub 2021 Jan 21.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.

Aim: The aim of this study is to describe the clinical and pathologic features of corneal primary acquired melanosis (PAM) and melanoma.

Methods: We describe 3 cases in total: two cases of corneal melanomas and 1 case of corneal PAM. The eyes were processed routinely for histopathological examination. Read More

View Article and Full-Text PDF

Case of a Giant Conjunctival Melanocytic Nevus.

Ocul Oncol Pathol 2021 Mar 18;7(2):97-102. Epub 2020 Dec 18.

Department of Ophthalmology, Kansai Medical University, Osaka, Japan.

A 78-year-old female experienced extraocular extension of a giant conjunctival melanocytic mass. The clinical diagnosis was conjunctival malignant melanoma. We performed local excision and histopathological examination. Read More

View Article and Full-Text PDF

A Rare Case of Conjunctival Melanoma with Orbital Invasion.

Nepal J Ophthalmol 2020 Jul;12(24):352-354

Universidad del Valle; Ocular Health Research Group, Grupo de Investigación en Salud Ocular (GISOC-UV), Hospital Universitario del Valle, Universidad del Valle, Cali, Colombia.

View Article and Full-Text PDF

Ocular Oncology-Primary and Metastatic Malignancies.

Med Clin North Am 2021 May 2;105(3):531-550. Epub 2021 Apr 2.

Medicine, 231 Albert Sabin Way, Suite 5412, Cincinnati, OH 45267-0567, USA. Electronic address: https://twitter.com/mauradinicola.

Several neoplastic processes can involve the eye, either primarily or secondary to a systemic malignancy. The most common primary tumors of the eye include conjunctival and uveal melanoma, retinoblastoma, conjunctival and intraocular lymphoma, and ocular surface squamous neoplasia. Metastatic spread from systemic malignancies, especially of the breast and lung, also can involve the eye. Read More

View Article and Full-Text PDF

Iatrogenic Ocular Surface Diseases Occurring during and/or after Different Treatments for Ocular Tumours.

Cancers (Basel) 2021 Apr 16;13(8). Epub 2021 Apr 16.

Service d'ophtalmologie, Ophtalmopôle de Paris, Hôpital Cochin, AP-HP, F-75014 Paris, France.

The ocular surface represents a finely regulated system that allows the protection of the eye. It is particularly susceptible to different treatments for intraocular tumours, such as uveal melanoma and conjunctival cancers. Traditionally, the management of ocular tumours depends on the characteristics of the lesion, and is based on a combination of selective surgery, topical chemotherapy, and/or radiotherapy delivered through different mechanisms (e. Read More

View Article and Full-Text PDF

Scleral necrosis after brachytherapy for uveal melanoma: Analysis of risk factors.

Clin Exp Ophthalmol 2021 Apr 17. Epub 2021 Apr 17.

Department of Ophthalmology, University Hospital of Essen, Essen, Germany.

Background: Radiation-induced scleral necrosis (RISN) is a rare, but a serious complication of brachytherapy for uveal melanoma. We aimed at analysing the incidence, timing and risk factors associated with development of RISN in a large institutional series.

Methods: All consecutive cases with brachytherapy for uveal melanoma treated by the Departments of Ophthalmology and Radiotherapy at University Hospital Essen between 1999 and 2016 were eligible. Read More

View Article and Full-Text PDF

Adopting low-shot deep learning for the detection of conjunctival melanoma using ocular surface images.

Comput Methods Programs Biomed 2021 Jun 3;205:106086. Epub 2021 Apr 3.

B&VIIT Eye Center, Seoul, South Korea; VISUWORKS, Seoul, South Korea.

Background And Objective: The purpose of the present study was to investigate low-shot deep learning models applied to conjunctival melanoma detection using a small dataset with ocular surface images.

Methods: A dataset was composed of anonymized images of four classes; conjunctival melanoma (136), nevus or melanosis (93), pterygium (75), and normal conjunctiva (94). Before training involving conventional deep learning models, two generative adversarial networks (GANs) were constructed to augment the training dataset for low-shot learning. Read More

View Article and Full-Text PDF

Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway.

Cell Death Dis 2021 Apr 7;12(4):380. Epub 2021 Apr 7.

State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, 130 Mei Long Road, Shanghai, 200237, China.

Conjunctival melanoma (CM) is a rare and fatal ocular tumour with poor prognosis. There is an urgent need of effective therapeutic drugs against CM. Here, we reported the discovery of a novel potential therapeutic target for CM. Read More

View Article and Full-Text PDF

Sunglasses to hide behind may also prevent melanoma of the eyes.

Br J Cancer 2021 Apr 6. Epub 2021 Apr 6.

Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, SK10 4TG, UK.

In 1967, Sandy Posey pronounced that sunglasses are essential beachwear ( https://www.youtube.com/watch?v=4HVBEb-GA1Y ). Read More

View Article and Full-Text PDF

Nuclear Medicine and Molecular Imaging in Nodal Staging and Surveillance of Ocular Melanoma: Cases Report and Review of Literature.

J Nucl Med Technol 2021 Apr 5. Epub 2021 Apr 5.

Mayo Clinic Arizona, United States.

Ocular melanoma (OM) is a rare noncutaneous malignancy and consists of 2 different subtypes based on anatomic location in the eye: uveal melanoma (UM) and conjunctival melanoma (CM). As in cutaneous melanoma, nuclear medicine and molecular imaging play valuable roles in the nodal staging and clinical management of OM. Through the illustration of 2 distinctive cases, we aim to demonstrate the complementary roles of standard lymphoscintigraphy, advanced single-photon emission computed tomography/computed tomography, 18F-fludeoxyglucose positron emission tomography/computed tomography, and hybrid positron emission tomography/magnetic resonance imaging in accurate nodal staging and surveillance of OM. Read More

View Article and Full-Text PDF

Targeting the YAP/TAZ Pathway in Uveal and Conjunctival Melanoma With Verteporfin.

Invest Ophthalmol Vis Sci 2021 Apr;62(4)

Department of Ophthalmology, Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, United States.

Purpose: The purpose of this study was to determine whether YAP/TAZ activation in uveal melanoma (UM) and the susceptibility of melanoma cell lines to YAP/TAZ inhibition by verteporfin (VP) is related to the tumor's genetic background.

Methods: Characteristics of 144 patients with enucleated UM were analyzed together with mRNA expression levels of YAP/TAZ-related genes (80 patients from the The Cancer Genome Atlas [TCGA] project and 64 patients from Leiden, The Netherlands). VP was administered to cell lines 92. Read More

View Article and Full-Text PDF

Age Conditional Probability of Ocular and Ocular Adnexal Malignancies.

Ocul Oncol Pathol 2021 Mar 16;7(1):70-73. Epub 2020 Nov 16.

Department of Ophthalmology, Pathology and Cell Biology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.

Aim: The aim of this study was to discuss and illustrate the role age-conditional probability has in communicating risk of developing ocular and ocular adnexal malignancies.

Methods: Cross-sectional incidence for retinoblastoma, uveal melanoma, conjunctival melanoma, and lacrimal gland carcinomas from 2000 to 2017 were obtained from the Surveillance, Epidemiology and End Results (SEER) database. Incidence rates were age-adjusted to the 2000 United States population. Read More

View Article and Full-Text PDF

Conjunctival melanoma: outcomes based on tumour origin in 629 patients at a single ocular oncology centre.

Eye (Lond) 2021 Mar 26. Epub 2021 Mar 26.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: To investigate clinical features and outcomes of conjunctival melanoma classified by tumour origin.

Methods: Retrospective review of conjunctival melanoma patients at a single ocular oncology centre between April 18, 1974 and September 9, 2019. Lesions were divided into three tumour origin groups (primary acquired melanosis [PAM], nevus, and de novo) and clinical features and outcomes were compared. Read More

View Article and Full-Text PDF

Conjunctival Intraepithelial Neoplasia in a Patient Presenting with Pigmented Conjunctival Lesion.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):77-82. Epub 2021 Jan 21.

Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

We report a case of conjunctival intraepithelial neoplasia (CIN) in a patient presenting with the pigmented conjunctival lesion. This study involved a 56-year-old woman that presented with right eye irritation for 1 month. She noticed brownish pigmentation arising from her right nasal conjunctiva and growing slowly over time. Read More

View Article and Full-Text PDF
January 2021

Orbital exenteration for conjunctival melanoma: comparison of long-term outcome between individualised and conventional techniques.

Eye (Lond) 2021 Feb 19. Epub 2021 Feb 19.

Department of Ophthalmology, Fudan Eye & ENT Hospital, Shanghai, China.

Background: Growing evidence supports an individualised approach rather than radical surgery for conjunctival melanoma (CM). This study aimed to compare the long-term outcome between individualised and conventional exenteration techniques.

Methods: Our study retrospectively recruited advanced CM (clinical T3 stage) patients treated with individualised (13 cases) or conventional (18 cases) exenteration from June 2014 to April 2019. Read More

View Article and Full-Text PDF
February 2021

mA RNA hypermethylation-induced BACE2 boosts intracellular calcium release and accelerates tumorigenesis of ocular melanoma.

Mol Ther 2021 Jun 15;29(6):2121-2133. Epub 2021 Feb 15.

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai 200001, China. Electronic address:

Ocular melanoma, including uveal melanoma (UM) and conjunctival melanoma (CM), is the most common and deadly eye cancer in adults. Both UM and CM originate from melanocytes and exhibit an aggressive growth pattern with high rates of metastasis and mortality. The integral membrane glycoprotein beta-secretase 2 (BACE2), an enzyme that cleaves amyloid precursor protein into amyloid beta peptide, has been reported to play a vital role in vertebrate pigmentation and metastatic melanoma. Read More

View Article and Full-Text PDF

Indocyanine Green Angiographic Assessment of Conjunctival Melanocytic Disorders.

Cornea 2021 Feb 15. Epub 2021 Feb 15.

Department Ophthalmology, Medical University of Innsbruck, Austria; and Department of Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom.

Purpose: To investigate whether transvascular indocyanine green (ICG) dye leakage is associated with conjunctival malignancy.

Methods: This is a prospective interventional study. Patients presenting with circumscribed conjunctival melanocytic disorders (CMDs) were included and examined using color photography, anterior segment optical coherence tomography to measure lesion size, and fluorescein and ICG angiography to measure vascular pattern and leakage. Read More

View Article and Full-Text PDF
February 2021

Secondary orbital exenteration for conjunctival melanoma: A study of 25 cases.

J Fr Ophtalmol 2021 Mar 8;44(3):415-419. Epub 2021 Feb 8.

Service d'oncologie oculaire, Institut Curie, 26, rue d'Ulm, 75248 Paris cedex 05, France.

Introduction: The treatment of conjunctival melanoma is most often conservative, but exenteration is sometimes necessary in order to achieve local control of the disease. It can be performed as a primary procedure in cases of locally advanced disease or as a secondary procedure after one or more recurrences. No benefit to secondary exenteration on patient survival has been demonstrated to date for conjunctival melanoma, and it is generally considered a palliative procedure. Read More

View Article and Full-Text PDF

Conjunctival and uveal melanoma: Survival and risk factors following orbital exenteration.

Eur J Ophthalmol 2021 Feb 11:1120672121995131. Epub 2021 Feb 11.

Department of Oral and Maxillofacial Surgery, University of Duisburg-Essen, Essen, Germany.

Purpose: This study aims to analyse disease-free survival, overall survival and risk factors after orbital exenteration in patients with conjunctival and uveal melanoma.

Methods: Patients who underwent orbital exenteration due to conjunctival and uveal melanoma were included in this retrospective study (March 2000 to March 2018).

Results: A total of 76 patients were enrolled in this study: 60 patients had a conjunctival melanoma and 16 had a uveal melanoma. Read More

View Article and Full-Text PDF
February 2021

Giant conjunctival melanoma in a paranoid schizophrenic man: A case report.

Ann Med Surg (Lond) 2021 Feb 26;62:391-394. Epub 2021 Jan 26.

Department of Plastic Surgery, Faculty of Medicine Diponegoro University, Dr. Kariadi General Hospital, Jl. Dr. Sutomo No. 16, Randusari, Semarang Selatan, Semarang, Jawa Tengah, 50244, Indonesia.

Introduction: and importance: Conjunctival melanoma (CM) is a rare and potentially lethal ocular tumor. As with any oncologic disease, early diagnosis and appropriate treatment of CM is paramount to limit morbidity and increase life expectancy. However, patients with severe mental disability with social isolation are usually presented in late-stage disease. Read More

View Article and Full-Text PDF
February 2021

The Evaluation of the Malignant Characteristics of Conjunctival Lesions Based on the Dermatoscopic Algorithm.

Anticancer Res 2021 Feb;41(2):895-903

Jagiellonian University Medical College, Faculty of Medicine, Department of Ophthalmology and Ocular Oncology, Krakow, Poland;

Background/aim: This study analysed the prevalence of the characteristics evaluated in dermatoscopy for melanocytic infiltrations of the conjunctiva with various degrees of malignancy.

Patients And Methods: A total of 160 conjunctival pigmented lesions were studied. Each lesion was scored using dermatoscopic patterns and the characteristics of malignancy described by Kittler. Read More

View Article and Full-Text PDF
February 2021

Genetic drivers of non-cutaneous melanomas: Challenges and opportunities in a heterogeneous landscape.

Exp Dermatol 2021 Jan 17. Epub 2021 Jan 17.

Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.

Non-cutaneous melanomas most frequently involve the uveal tract and mucosal membranes, including the conjunctiva. In contrast to cutaneous melanoma, they often present at an advanced clinical stage, are associated with worse clinical outcomes and show poorer responses to immunotherapy. The mutational load within most non-cutaneous melanomas reflects their lower ultraviolet light (UV) exposure. Read More

View Article and Full-Text PDF
January 2021

Clinical Characteristics of UM and Association of Metastasis of Uveal Melanoma with Congenital Oculocutaneous Melanosis in Asian Patients: Analysis of 1151 Consecutive Eyes.

Ophthalmol Retina 2021 Jan 12. Epub 2021 Jan 12.

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Medical Artificial Intelligence Research and Verification Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address:

Purpose: To analyze the clinical characteristics of uveal melanoma (UM) and evaluate the relationship of congenital oculocutaneous melanosis (OCM) to the prognosis of Asian patients with UM.

Design: Retrospective cohort study.

Participants: We included a total of 1151 Asian patients with UM who were managed at the Beijing Tongren Hospital from June 26, 2005, to July 27, 2020. Read More

View Article and Full-Text PDF
January 2021