1,312 results match your criteria Melanoma Ciliary Body


Five Decades of Enucleations for Uveal Melanoma in One Center: More Tumors with High Risk Factors, No Improvement in Survival over Time.

Ocul Oncol Pathol 2021 Mar 15;7(2):133-141. Epub 2020 Dec 15.

Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.

Background: In order to improve medical care for uveal melanoma (UM) patients, we need to monitor disease and survival to guide our research efforts. We analyzed the data of UM patients who underwent an enucleation at the Leiden University Medical Center over the last five decades and investigated trends in patient and tumor characteristics and survival.

Methods: Data were collected from charts and pathology reports from all patients who underwent an enucleation for UM between 1973 and 2019 ( = 1,212), of which 1,066 were primary enucleations; data were analyzed according to five time periods: 1973-1979 ( = 209), 1980-1989 ( = 148), 1990-1999 ( = 174), 2000-2009 ( = 280), and 2010-2019 ( = 401). Read More

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Large Hemorrhagic Extrascleral Ciliary Body Melanoma Recurrence Treated With Transarterial Embolization and Coiling Followed by Exenteration.

Ophthalmic Plast Reconstr Surg 2021 Apr 28. Epub 2021 Apr 28.

Department of Radiology Regional Hospital St. Gallen Department of Dermatology Regional Hospital St. Gallen Department of Pathology Regional Hospital St. Gallen Department of Ophthalmology, Regional Hospital St. Gallen University of Zurich, Zurich, Switzerland.

A 59-year-old male patient who suffered from a systemically metastasized, large extrascleral uveal melanoma recurrence of the left eye presented with active hemorrhage from the tumor. He had undergone proton beam irradiation for an epithelioid ciliary body melanoma 4 years before presentation and was lost to follow-up. Magnetic resonance angiography showed vascularization of the lesion via the ophthalmic and maxillary artery. Read More

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Eye Tumors in Childhood as First Sign of Tumor Predisposition Syndromes: Insights from an Observational Study Conducted in Germany and Austria.

Cancers (Basel) 2021 Apr 14;13(8). Epub 2021 Apr 14.

Institute of Human Genetics, Medical Faculty, University Duisburg-Essen, 45122 Essen, Germany.

Retinoblastoma and other eye tumors in childhood are rare diseases. Many eye tumors are the first signs of a genetic tumor predisposition syndrome and the affected children carry a higher risk of developing other cancers later in life. Clinical and genetic data of all children with eye tumors diagnosed between 2013-2018 in Germany and Austria were collected in a multicenter prospective observational study. Read More

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Rapid growth of primary uveal melanoma following intravitreal bevacizumab injection: a case report and review of the literature.

Digit J Ophthalmol 2021 Feb 3;26(3):27-30. Epub 2020 Jul 3.

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alberta, Canada.

Uveal melanoma size is a significant predictor of tumor metastasis. Although the relationship between antivascular endothelial growth factors (VEGF) and uveal melanoma growth has been studied, results are paradoxical, and the relationship remains controversial. We report the case of a 65-year-old man who presented with elevated intraocular pressure in his right eye, neovascularization of his iris, and significant corneal edema, which obscured the view of the angle. Read More

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February 2021

Scleral necrosis after brachytherapy for uveal melanoma: Analysis of risk factors.

Clin Exp Ophthalmol 2021 Apr 17. Epub 2021 Apr 17.

Department of Ophthalmology, University Hospital of Essen, Essen, Germany.

Background: Radiation-induced scleral necrosis (RISN) is a rare, but a serious complication of brachytherapy for uveal melanoma. We aimed at analysing the incidence, timing and risk factors associated with development of RISN in a large institutional series.

Methods: All consecutive cases with brachytherapy for uveal melanoma treated by the Departments of Ophthalmology and Radiotherapy at University Hospital Essen between 1999 and 2016 were eligible. Read More

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Locally Invasive Diffuse Iris Ring Melanoma Presenting as Unilateral Severe Glaucoma: Case Report and Review of Molecular Genetics.

Case Rep Oncol 2021 Jan-Apr;14(1):403-410. Epub 2021 Mar 11.

Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas, USA.

We report the clinical history and histopathological findings in a case of diffuse iris ring melanoma (DIM) and review the most recent literature and modern molecular genetics of this entity. An 85-year-old Hispanic man presented with severe unilateral glaucoma, managed at an outside institution for 2 years prior to presentation. Diffuse pigmentation was noted in the angle, on the intraocular lens implant, and in the vitreous without clear demonstration of a mass on ultrasound biomicroscopy. Read More

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Doppelgänger dilemma: Leiomyoma versus uveal melanoma.

Am J Ophthalmol Case Rep 2021 Jun 6;22:101040. Epub 2021 Mar 6.

The New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA.

Background: Ciliary body tumors can remain undetected and achieve large dimensions. Pigmented ciliary body tumors include: melanoma, leiomyoma and melanocytoma, however correct diagnosis may require tissue diagnosis with immunohistochemical stains.

Case Presentation: Two men presented with identical ciliochoroidal tumors. Read More

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Clinicopathologic analysis of 32 ciliary body tumors.

Jpn J Ophthalmol 2021 Mar 19;65(2):237-249. Epub 2021 Feb 19.

Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Purpose: To describe the demographic profile, clinical and histopathologic features, and treatment of ciliary body tumors.

Study Design: Retrospective, observational case series.

Methods: Thirty-two patients (32 eyes) with ciliary body tumors diagnosed histopathologically at Tokyo Medical University Hospital between 1994 and 2017 were retrospectively reviewed. Read More

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Optimising prediction of early metastasis-free survival in uveal melanoma using a four-category model incorporating gene expression profile and tumour size.

Br J Ophthalmol 2021 Feb 15. Epub 2021 Feb 15.

Department of Ophthalmology and Visual Sciences, University of Alberta Faculty of Medicine & Dentistry, Edmonton, Alberta, Canada

Background: Largest basal diameter (LBD) appears to have independent prognostic value in uveal melanoma (UM).

Methods: All patients undergoing plaque brachytherapy or enucleation for UM involving the choroid and/or ciliary body between 2012 and 2019.

Results: A total of 348 patients with a mean age of 60±14 years were included and followed for a mean of 40±26 months (3. Read More

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February 2021

Patients presenting with metastases: stage IV uveal melanoma, an international study.

Br J Ophthalmol 2021 Jan 15. Epub 2021 Jan 15.

Department of Ophthalmic Oncology, National Cancer Center Hospital, Tokyo, Japan.

Objective: To analyse ocular and systemic findings of patients presenting with systemic metastasis.

Methods And Analysis: It is an international, multicentre, internet-enabled, registry-based retrospective data analysis. Patients were diagnosed between 2001 and 2011. Read More

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January 2021

Clinical Characteristics of UM and Association of Metastasis of Uveal Melanoma with Congenital Oculocutaneous Melanosis in Asian Patients: Analysis of 1151 Consecutive Eyes.

Ophthalmol Retina 2021 Jan 12. Epub 2021 Jan 12.

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Medical Artificial Intelligence Research and Verification Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address:

Purpose: To analyze the clinical characteristics of uveal melanoma (UM) and evaluate the relationship of congenital oculocutaneous melanosis (OCM) to the prognosis of Asian patients with UM.

Design: Retrospective cohort study.

Participants: We included a total of 1151 Asian patients with UM who were managed at the Beijing Tongren Hospital from June 26, 2005, to July 27, 2020. Read More

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January 2021

Uveal Melanoma Metastasis to the Contralateral Eye Structures: A Retrospective Comparative Analysis of 13 Consecutive Patients.

Ophthalmol Retina 2021 Jan 7. Epub 2021 Jan 7.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:

Purpose: To report uveal melanoma (UM) metastasis to the contralateral ocular and periocular structures.

Design: Retrospective study.

Participants: Thirteen patients with UM metastasis to the contralateral ocular and periocular structures were included. Read More

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January 2021

Estimating Cured Fractions of Uveal Melanoma.

JAMA Ophthalmol 2021 02;139(2):174-181

Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.

Importance: The extent to which uveal melanoma is cured by ocular therapy is not known.

Objective: To estimate cured fractions (CF) of uveal melanoma using combination of institutional and Surveillance, Epidemiology, and End Results (SEER) data.

Design, Setting, And Participants: Integrative analysis of 42 years of SEER data (1975-2016) with 25 years (1993-2018) of complementary institutional data. Read More

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February 2021

Proton beam irradiation of uveal melanoma involving the iris, ciliary body and anterior choroid without surgical localisation (light field).

Br J Ophthalmol 2020 Dec 21. Epub 2020 Dec 21.

Retina Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

Aims: To assess treatment outcomes after proton beam irradiation (PBI) without surgical localisation of uveal melanomas involving the iris, ciliary body and anterior choroid.

Methods: Retrospective chart review of 125 patients evaluated at Massachusetts Eye and Ear and treated with PBI using a light field set-up without localisation surgery between November 1975 and April 2017. The tumours were characterised as follows: iris (n=18, 14. Read More

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December 2020

Sclerouvectomy plus intraoperative ophthalmic brachytherapy for iris-ciliary body melanomas.

Surg Oncol 2021 Mar 11;36:113-114. Epub 2020 Dec 11.

Retina Unit, Department of Ophthalmology, Virgen Macarena University Hospital, Seville, Spain; RETICS OftaRed, Institute of Health Carlos III, Madrid, Spain.

Background: Partial lamellar sclerouvectomy was designed more than 30 years ago by Jerry and Carol Shields, in order to remove melanomas that involved the ciliary body and/or the choroid, while leaving intact the outer portion of the sclera and the overlying sensory retina [1].

Methods: We present two cases of iris-ciliary body melanoma with different size. The performed surgery was a partial lamellar sclerouvectomy plus iridectomy, complemented by intraoperative juxtalimbar ruthenium-106 brachytherapy. Read More

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Three-dimensional MRI-based treatment planning approach for non-invasive ocular proton therapy.

Med Phys 2021 Mar 17;48(3):1315-1326. Epub 2021 Jan 17.

Department of Radiation Oncology, Erasmus Medical Center, Rotterdam, The Netherlands.

Purpose: To develop a high-resolution three-dimensional (3D) magnetic resonance imaging (MRI)-based treatment planning approach for uveal melanomas (UM) in proton therapy.

Materials/methods: For eight patients with UM, a segmentation of the gross tumor volume (GTV) and organs-at-risk (OARs) was performed on T1- and T2-weighted 7 Tesla MRI image data to reconstruct the patient MR-eye. An extended contour was defined with a 2. Read More

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Doctor reported outcomes: Real-world data from a tertiary eye cancer center.

Indian J Ophthalmol 2021 Jan;69(1):135-139

Department of Ocular Tumor and Orbital Disease, The New York Eye Cancer Center, New York, NY, USA.

Purpose: To provide real-world data on the world-wide-web for patient and doctor awareness.

Methods: From December 2017 to January 2020, consecutive patients with choroidal melanoma (CM), iris ciliary body melanoma (ICM), and ocular surface squamous carcinoma (OSSC) had specific outcomes recorded at each return visit. Each result was anonymized, entered in an online portal, and sent to a unique software program where it was used to create real-world data of number of patients, mean vision, local tumor control, eye salvage, systemic metastases, and length of follow-up for our eye cancer center. Read More

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January 2021

A case of ciliary body mesectodermal leiomyoma with rapid growth and loss of vision necessitating enucleation.

Ann Med Surg (Lond) 2020 Dec 27;60:651-653. Epub 2020 Nov 27.

King Saud University Medical City (KSUMC), King Saud University, Riyadh, PO Box: 266, Postal Code: 11362, Saudi Arabia.

Introduction: Mesectodermal leiomyoma of the ciliary body is a benign rare tumor that rarely presents acutely with a complicated clinical course.

Presentation Of Case: We are reporting a 39-year-old healthy female who presented with subacute blurred vision in her right eye secondary to a ciliary body mass. Initial fine needle aspiration biopsy ruled out a melanoma but the patient meanwhile experienced rapid complicated growth of the mass with vision loss, for which her right globe was eventually enucleated. Read More

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December 2020

Large Choroidal Melanocytoma Simulating Choroidal Melanoma: A Difficult Differential Diagnosis and an Inevitable Enucleation.

Case Rep Ophthalmol Med 2020 21;2020:8890857. Epub 2020 Nov 21.

Department of Ophthalmology, Military Teaching Hospital Med-V, Rabat, Morocco.

Purpose: To describe a case of choroidal melanocytoma mimicking a melanoma.

Methods: Retrospective case report. . Read More

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November 2020

Eye plaque brachytherapy versus enucleation for ocular melanoma: an analysis from the National Cancer Database.

J Contemp Brachytherapy 2020 Aug 21;12(4):303-310. Epub 2020 Aug 21.

Department of Radiation Oncology, Houston Methodist Hospital, Houston, TX, USA.

Purpose: There is no current randomized data comparing the efficacy of brachytherapy and enucleation for patients with larger sized tumors. The purpose of the present study was to use a large, contemporary database to determine current practice patterns and compare survival outcomes between different management options for patients with choroidal melanoma of various sizes.

Material And Methods: The National Cancer Database was queried (2004-2014) for histologically-confirmed choroidal melanoma for patients treated with brachytherapy versus enucleation. Read More

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Epidemiology of uveal melanoma in Brazil.

Int J Retina Vitreous 2020 Nov 11;6(1):51. Epub 2020 Nov 11.

Clinical Research Division, Brazilian National Cancer Institute-COPQ/INCA, Rua André Cavalcanti, 37-50 Andar - Anexo, Centro, Rio de Janeiro, RJ, 20231-050, Brazil.

Purpose: To report the prevalence of uveal melanoma in a Hospital database in Brazil over the period of 16 years (2000 to 2016).

Design: Descriptive epidemiological study evaluating the Brazilian Hospital Based Cancer Registries.

Participants/methods: Uveal melanomas were identified based on ICD-O-3 codes C69. Read More

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November 2020

Choroidal vascularization and adrenergic innervation qualitative findings obtained with induced fluorescence preparations and optical coherence tomography angiography: possible correlations and perspectives.

Int J Retina Vitreous 2020 Nov 30;6(1):61. Epub 2020 Nov 30.

Department of Ophthalmology, San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Via Olgettina 60, 20132, Milan, Italy.

Background: Recent advances in optical coherence tomography (OCT) technology allow a more accurate choroidal visualization. The aim of this study is to provide histochemical analysis with induced fluorescence images of the choroidal stromal, vascular and nerve network, highlighting possible correspondences with OCT and OCT angiography (OCT-A) analysis.

Methods: The material examined with a histochemical process of induced fluorescence through condensation of biologically active monoamines with glyoxylic acid was obtained from 6 eyes enucleated for malignant melanoma and ciliary body neoplasia. Read More

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November 2020

Research Progress of Cancer Stem Cells in Uveal Melanoma.

Onco Targets Ther 2020 27;13:12243-12252. Epub 2020 Nov 27.

Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, People's Republic of China.

Uveal melanoma is the most common malignant tumor in adult eyes, mostly in the choroid, but also in the iris and ciliary body. Distant metastasis is found in nearly half of the patients. Cancer stem cells are a kind of cells with the ability of self-renewal and multidirectional differentiation, which are related to tumor invasion and metastasis. Read More

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November 2020

Clinical outcomes of Modified Collaborative Ocular Melanoma Study IRIS plaques for treatment of iris, iridociliary, and ciliary body melanoma.

Eye (Lond) 2020 Nov 24. Epub 2020 Nov 24.

Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA.

Background/objectives: To report clinical outcomes of modified Collaborative Ocular Melanoma Study IRIS (COMS IRIS) plaques for treatment of iris, iridociliary, and ciliary body melanoma.

Subjects/methods: Retrospective, single-centre cohort study of iris melanoma treated with COMS IRIS plaque radiotherapy from July 26, 2010 to October 15, 2018. Medical records were reviewed for demographics, tumour features, treatment parameters, and clinical outcomes. Read More

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November 2020

Update on uveal melanoma: Translational research from biology to clinical practice (Review).

Int J Oncol 2020 Dec 22;57(6):1262-1279. Epub 2020 Oct 22.

Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, 28871 Madrid, Spain.

Uveal melanoma is the most common type of intraocular cancer with a low mean annual incidence of 5‑10 cases per million. Tumours are located in the choroid (90%), ciliary body (6%) or iris (4%) and of 85% are primary tumours. As in cutaneous melanoma, tumours arise in melanocytes; however, the characteristics of uveal melanoma differ, accounting for 3‑5% of melanocytic cancers. Read More

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December 2020

A 45-year experience of uveal melanoma in Taiwan: Verification of American Joint Committee on Cancer staging system and prognostic factors.

J Formos Med Assoc 2020 Oct 27. Epub 2020 Oct 27.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan; College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: To verify the staging system of the American Joint Committee on Cancer (AJCC) 8th edition for uveal melanoma, and to propose the prognostic factors of uveal melanoma by a 45-year cohort study.

Methods: We collected patients who underwent operation with pathological proof from 1973 to 2017. The demographic data including gender, age, laterality, metastatic pattern, and histopathology type were recorded. Read More

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October 2020

Two Cases of Giant Melanocytoma (Hyperpigmented Magnocellular Nevus).

Ocul Oncol Pathol 2020 Oct 2;6(5):344-352. Epub 2020 Jun 2.

Department of Ophthalmology and Visual Sciences, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Melanocytoma or hyperpigmented magnocellular nevus is a variant of melanocytic nevus that is most commonly seen in the optic nerve, but has also been reported to occur in the iris, ciliary body, choroid, sclera, and conjunctiva. We present two cases of giant uveal melanocytoma with histopathology. The first case occurred in a 10-year-old girl who presented with decreased vision in the right eye and a mushroom-shaped pigmented choroidal lesion measuring 15. Read More

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October 2020

Case Report with Review of the Literature: Uveal Melanoma in a Patient with Carney Complex - Another Rare Component of the Syndrome?

Ocul Oncol Pathol 2020 Oct 21;6(5):311-317. Epub 2020 Apr 21.

Emeritus Member, Mayo Clinic, Rochester, Minnesota, USA.

A 74-year-old woman with Carney complex (CNC) and complaints of poor vision was found, on ophthalmic examination, to have a pigmented tumor involving the peripheral choroid and ciliary body in her right eye. The eye was enucleated and showed a ciliochoroidal melanoma with marked pleomorphism. The tumor did not recur or metastasize after almost 10 years of follow-up, and the patient died of unrelated causes. Read More

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October 2020