1,260 results match your criteria Melanoma Ciliary Body


Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours.

Nat Commun 2020 May 15;11(1):2408. Epub 2020 May 15.

QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

Uveal melanoma (UM) is the most common intraocular tumour in adults and despite surgical or radiation treatment of primary tumours, ~50% of patients progress to metastatic disease. Therapeutic options for metastatic UM are limited, with clinical trials having little impact. Here we perform whole-genome sequencing (WGS) of 103 UM from all sites of the uveal tract (choroid, ciliary body, iris). Read More

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http://dx.doi.org/10.1038/s41467-020-16276-8DOI Listing

A non-contiguous recurrence of the ciliary body melanoma-is cataract surgery a risk factor?

Int J Ophthalmol 2020 18;13(4):681-683. Epub 2020 Apr 18.

University Eye Clinic, University Hospital Centre Zagreb, Zagreb 10000, Croatia.

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http://dx.doi.org/10.18240/ijo.2020.04.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137701PMC

Not every pigmented tumour is melanoma: Adenoma of the ciliary body pigment epithelium.

Arch Soc Esp Oftalmol 2020 Apr 23. Epub 2020 Apr 23.

Departamento de Órbita y Oculoplástica, Fundación Hospital «Nuestra Señora de la Luz», IAP, Ciudad de México, México.

Differential diagnosis between a melanoma and a pseudomelanoma requires many years of experience and ocular studies, and requires paying attention to the smallest details. The case is presented of a 57 year-old male with an adenoma of the ciliary body pigment epithelium that was treated with an enucleation of the eye due to a suspicion of a choroidal melanoma. Read More

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http://dx.doi.org/10.1016/j.oftal.2020.03.009DOI Listing

Ciliary Body Seeding after Pars Plana Transvitreal Fine-Needle Aspiration Biopsy of Choroidal Melanoma.

J Ophthalmic Vis Res 2020 Apr-Jun;15(2):252-255. Epub 2020 Apr 6.

Wills Eye Hospital, Ocular Oncology Service, Philadelphia, PA, USA.

Purpose: To report ciliary body seeding 20 years after pars plana transvitreal fine needle aspiration biopsy (FNAB) of choroidal melanoma.

Case Report: 67-year-old man with choroidal melanoma in left eye was previously managed with pars plana FNAB using a 25-gauge needle followed by plaque radiotherapy. Twenty years later, choroidal melanoma was regressed but there was a small flat focus of scleral pigment 3. Read More

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http://dx.doi.org/10.18502/jovr.v15i2.6744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151516PMC

[Characteristics of CMR Appearance in a Case of Cardiac Metastatic Melanoma].

Sichuan Da Xue Xue Bao Yi Xue Ban 2020 Mar;51(2):264-266

Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.

A 53-year-old woman was found "an occupant in the left ciliary body" two years ago and underwent the surgery of "left eye ball removal". Pathological results confirmed the diagnosis of malignant melanoma. The patient was admitted to our hospital again due to newly found heart murmur. Read More

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http://dx.doi.org/10.12182/20200360106DOI Listing

Glaucoma as the presenting sign of intraocular tumors: beware of the masquerading sign.

Int Ophthalmol 2020 Mar 20. Epub 2020 Mar 20.

Ophthalmic Plastic Surgery and Ocular Oncology Services, The Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, 500034, India.

Purpose: To discuss the clinical presentation and management of intraocular tumors masquerading as primary glaucoma or non-tumor-related secondary glaucoma.

Methods: Retrospective chart review.

Results: Ten patients with unsuspected intraocular tumor were referred to glaucoma clinic with a diagnosis of primary glaucoma or non-tumor-related secondary glaucoma. Read More

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http://dx.doi.org/10.1007/s10792-020-01348-xDOI Listing

NCCN Guidelines Insights: Uveal Melanoma, Version 1.2019.

J Natl Compr Canc Netw 2020 02;18(2):120-131

National Comprehensive Cancer Network.

The NCCN Guidelines for Uveal Melanoma include recommendations for staging, treatment, and follow-up of patients diagnosed with uveal melanoma of the choroid or ciliary body. In addition, because distinguishing between uveal melanoma and benign uveal nevi is in some cases difficult, these guidelines also contain recommendations for workup of patients with suspicious pigmented uveal lesions, to clarify the tests needed to distinguish between those who should have further workup and treatment for uveal melanoma versus those with uncertain diagnosis and low risk who should to be followed and later reevaluated. These NCCN Guidelines Insights describe recommendations for treatment of newly diagnosed nonmetastatic uveal melanoma in patients who have already undergone a complete workup. Read More

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http://dx.doi.org/10.6004/jnccn.2020.0007DOI Listing
February 2020
4.178 Impact Factor

Germline Mutation Associated with Bilateral Primary Uveal Melanoma.

Ocul Oncol Pathol 2020 Jan 4;6(1):10-14. Epub 2019 Jun 4.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Purpose: To describe the occurrence of bilateral primary uveal melanoma in 2 patients with mutation on the gene encoding BRCA1-associated protein 1 .

Methods: Retrospective chart review of patients with bilateral primary uveal melanoma and subsequent positive germline mutation.

Results: There were 2 patients with bilateral uveal melanoma and germline positivity. Read More

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http://dx.doi.org/10.1159/000499570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984137PMC
January 2020

Analysis of local recurrence causes in uveal melanoma patients treated with I brachytherapy - a single institution study.

J Contemp Brachytherapy 2019 Dec 16;11(6):554-562. Epub 2019 Dec 16.

Department of Ophthalmology and Ocular Oncology of the Jagiellonian University, Medical College, Kraków, Poland.

Purpose: To perform a retrospective analysis of factors which might affect the occurrence of a relapse of uveal melanoma after I brachytherapy.

Material And Methods: The analysis concerned 343 patients treated in the years 2001-2012. The effect on local recurrence of such factors as patient's sex, age, tumour size, shape, pigmentation, location, presence of orange pigment or petechiae on tumour surface, retinal detachment, and blood or dispersed pigment in vitreous body were studied. Read More

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http://dx.doi.org/10.5114/jcb.2019.90985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964341PMC
December 2019

Intraocular leiomyoma: Current concepts.

Surv Ophthalmol 2020 Jul - Aug;65(4):421-437. Epub 2020 Jan 7.

The New York Eye and Ear Infirmary, Mount Sinai Hospital, New York, NY, USA.

Intraocular leiomyoma is a benign smooth muscle tumor. First recognized before the era of immunohistochemistry, uveal leiomyomas have been described in case reports and small case series. We add 3 new cases, for a total of 80. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.12.008DOI Listing
January 2020

Meta-analysis on the utility of radiotherapy for the treatment of Ocular Melanoma

Clin Ter 2020 Jan-Feb;170(1):e89-e98

Department of Sense Organs, University of Rome “Sapienza”, Rome

Introduction: Uveal melanoma is the most common intraocular tumor in the adult population. It can affect any part of the uveal tract: the iris, ciliary body, and choroid. Historically, enucleation has been the mainstay of treatment for primary melanoma. Read More

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Aqueous Humor Biomarkers Identify Three Prognostic Groups in Uveal Melanoma.

Invest Ophthalmol Vis Sci 2019 11;60(14):4740-4747

Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.

Purpose: To investigate whether we can identify different patterns of inflammation in the aqueous humor of a uveal melanoma (UM)-containing eye, and whether these are related to prognosis.

Methods: Ninety samples of aqueous humor from UM-containing eyes were analyzed using a high-throughput multiplex immunoassay that enables simultaneous analysis of 92 predefined protein biomarkers. Cytokine expression was compared to clinical and histopathological characteristics. Read More

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http://dx.doi.org/10.1167/iovs.19-28309DOI Listing
November 2019

Glaucoma After Iodine-125 Brachytherapy for Uveal Melanoma: Incidence and Risk Factors.

J Glaucoma 2020 Jan;29(1):1-10

Stein Eye.

PRéCIS:: A single-center retrospective review over a 10-year period discovered an 8.6% risk of developing secondary open-angle glaucoma, and a 6.7% risk of neovascular glaucoma after brachytherapy for uveal melanoma. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001393DOI Listing
January 2020

Acute subconjunctival pigmentation with an underlying ciliary body mass: An unusual case presentation.

Saudi J Ophthalmol 2019 Jul-Sep;33(3):294-296. Epub 2019 Jul 17.

Dhahran Eye Specialist Hospital, Eastern Province, Saudi Arabia.

Intraocular melanocytoma is a rare slowly growing benign tumor that may occur anywhere along the uveal tract including the ciliary body but is more commonly found near the optic disc. It is darkly pigmented and may exhibit fast growth and possibly malignant transformation. Ciliary body (CB) melanocytoma is rare and often misdiagnosed as a melanoma. Read More

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http://dx.doi.org/10.1016/j.sjopt.2019.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819707PMC

Congenital choroidal melanocytoma in a child with ocular melanocytosis.

BMJ Case Rep 2019 Oct 30;12(10). Epub 2019 Oct 30.

Ocular Oncology, LV Prasad Eye Institute, Hyderabad, India

A 1-day-old child was brought to the clinic for evaluation of enlarged right eye (OD). On examination, OD showed buphthalmos with diffuse scleral melanocytosis, fleshy blackish-brown extrascleral mass with corneal extension, and secondary glaucoma. Anterior segment evaluation revealed darkly pigmented iris and fundus evaluation OD revealed a darkly pigmented choroidal lesion. Read More

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http://dx.doi.org/10.1136/bcr-2019-231376DOI Listing
October 2019

Uveal melanoma-associated survival in Scotland.

Eye (Lond) 2019 11 25;33(11):1699-1706. Epub 2019 Oct 25.

Scottish Ocular Oncology Service, Tennent Institute of Ophthalmology, Glasgow, UK.

Background/objectives: The Scottish Ocular Oncology Service (SOOS) manages all patients with uveal melanoma (UM) in Scotland. Our aim was to determine the long-term all-cause and cause-specific survival of patients with UM, irrespective of treatment modality.

Subjects/methods: A retrospective single-centre cohort study including all patients diagnosed with UM by the SOOS between 1/1/1998 and 31/12/2002. Read More

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http://dx.doi.org/10.1038/s41433-019-0622-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002729PMC
November 2019
4 Reads

Intraocular Biopsy and ImmunoMolecular Pathology for "Unmasking" Intraocular Inflammatory Diseases.

J Clin Med 2019 Oct 19;8(10). Epub 2019 Oct 19.

Vitreoretinal Department, Moorfields Eye Hospital, 162 City Rd, Old Street, London EC1V 2PD, UK.

Intraocular inflammation can hide a variety of eye pathologies. In 33% of cases, to obtain a correct diagnosis, investigation of the intraocular sample is necessary. The combined analyses of the intraocular biopsy, using immuno-pathology and molecular biology, point to resolve the diagnostic dilemmas in those cases where history, clinical tests, and ophthalmic and systemic examinations are inconclusive. Read More

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https://www.mdpi.com/2077-0383/8/10/1733
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http://dx.doi.org/10.3390/jcm8101733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832563PMC
October 2019
4 Reads

Pembrolizumab Induced Ocular Hypotony With Near Complete Vision Loss, Interstitial Pulmonary Fibrosis and Arthritis.

Front Oncol 2019 23;9:944. Epub 2019 Sep 23.

Goulburn Valley Health, Peninsula Health, Monash University, Melbourne, VIC, Australia.

Clinical outcomes for patients with advanced melanoma have improved significantly with the introduction of immune checkpoint inhibitors. These agents have distinct adverse effects with the potential for heightened host immune responses manifesting as an autoimmune reaction in any organ. We report a unique case who developed pembrolizumab induced arthritis, ocular hypotony with vision loss and pulmonary interstitial fibrosis. Read More

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http://dx.doi.org/10.3389/fonc.2019.00944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768006PMC
September 2019

The Potential Use of Electrochemotherapy in the Treatment of Uveal Melanoma: In Vitro Results in 3D Tumor Cultures and In Vivo Results in a Chick Embryo Model.

Cancers (Basel) 2019 Sep 11;11(9). Epub 2019 Sep 11.

Department of Ophthalmology, University Hospital Halle (Saale), Martin-Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120 Halle (Saale), Germany.

Uveal melanoma (UM) is the most common primary intraocular tumor that arises from neoplastic melanocytes in the choroid, iris, and ciliary body. Electrochemotherapy (ECT) has been successfully established for the treatment of skin and soft tissue metastatic lesions, deep-seated tumors of the liver, bone metastases, and unresectable pancreas lesions. The aim of this study was to evaluate the effect of ECT in vitro in 3D spheroid culture systems in primary and metastatic UM cell lines. Read More

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http://dx.doi.org/10.3390/cancers11091344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769976PMC
September 2019
2 Reads

Soluble HLA in the Aqueous Humour of Uveal Melanoma Is Associated with Unfavourable Tumour Characteristics.

Cancers (Basel) 2019 Aug 18;11(8). Epub 2019 Aug 18.

Department of Ophthalmology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

A high HLA expression in uveal melanoma (UM) is part of the prognostically unfavorable inflammatory phenotype. We wondered whether the presence of soluble HLA (sHLA) in the aqueous humour is associated with clinical, histopathological or genetic tumour characteristics, and represents tumour HLA expression and intratumoural inflammation. Aqueous humour from 108 UM patients was analysed for the presence of sHLA, using a Luminex assay specific for HLA Class I. Read More

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http://dx.doi.org/10.3390/cancers11081202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721510PMC
August 2019
1 Read

Neoadjuvant intravitreal ranibizumab treatment in high-risk ocular melanoma patients: a two-stage single-centre phase II single-arm study.

Melanoma Res 2020 02;30(1):102-106

Liverpool Ocular Oncology Centre, St Pauls Eye Unit, Royal Liverpool University Hospital, Liverpool, UK.

Despite an established history of intraocular antivascular endothelial growth factor (anti-VEGF) agents therapy in a variety of ocular pathologies as well as other cancer forms, use in the primary treatment of uveal melanoma has not been well assessed. This was a two-stage therapeutic and exploratory phase II, non-randomised, single centre trial involving intraocular treatment with 0.5 mg in 0. Read More

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http://Insights.ovid.com/crossref?an=00008390-900000000-9913
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http://dx.doi.org/10.1097/CMR.0000000000000635DOI Listing
February 2020
1 Read

Nomogram for visual acuity outcome after iodine-125 plaque radiotherapy and prophylactic intravitreal bevacizumab for uveal melanoma in 1131 patients.

Br J Ophthalmol 2020 May 13;104(5):697-702. Epub 2019 Aug 13.

Ocular Oncology Service, Wills Eye Hospital, Philadelphia, Pennsylvania, USA

Aims: To develop a nomogram for prediction of visual acuity outcome following plaque radiotherapy for uveal melanoma.

Methods: Retrospective review of uveal melanoma treated with plaque radiotherapy and prophylactic intravitreal bevacizumab injections at 4-month intervals for 2 years duration. Two nomograms for poor visual acuity outcome (Snellen <20/200) were developed based on (1) Clinical risk factors. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-314686DOI Listing
May 2020
3 Reads

RADIATION MACULOPATHY AFTER ONE-DAY SESSION STEREOTACTIC RADIOSURGERY IN PATIENTS WITH CILIARY BODY AND CHOROIDAL MELANOMA.

Cesk Slov Oftalmol 2019 ;75(1):3-10

Introduction: Nowadays radiotherapy is the standard treatment care for patients with uveal melanoma. In Slovakia the only one option is a one-day session stereotactic radiosurgery at linear accelerator LINAC. Irradiation of surrounding tissues of the eye and orbit causes radiation complications. Read More

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http://dx.doi.org/10.31348/2019/1/1DOI Listing
October 2019
3 Reads

A prospective trial of adjuvant therapy for high-risk uveal melanoma: assessing 5-year survival outcomes.

Br J Ophthalmol 2020 Apr 1;104(4):524-528. Epub 2019 Aug 1.

Department of Ophthalmic Oncology, Cleveland Clinic, Cole Eye Institute, Cleveland, Ohio, USA

Background/aims: Survival after diagnosis of metastasis from uveal melanoma is poor. Identifying individuals at high risk for metastasis and developing adjuvant therapy to prevent clinically apparent metastasis could improve survival. We conducted an adjuvant trial of sequential, low-dose dacarbazine (DTIC) and interferon-alpha-2b (IFN-α-2b) in patients with cytogenetic high-risk uveal melanoma. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-314461DOI Listing
April 2020
2 Reads

Melanoma-Associated Spongiform Scleropathy Adjacent to a Choroidal Nevus.

Ocul Oncol Pathol 2019 Jun 19;5(4):258-261. Epub 2018 Dec 19.

Morsani College of Medicine, Department of Ophthalmology, University of South Florida, Tampa, Florida, USA.

Melanoma-associated spongiform scleropathy contiguous to a choroidal nevus was an incidental finding in a 57-year-old woman whose eye was removed for a separate choroidal-ciliary body melanoma. All previously reported cases of melanoma-associated spongiform scleropathy, except for one, have been found adjacent to posterior uveal melanoma. The mechanism of scleral degeneration in melanoma-associated spongiform scleropathy is unknown. Read More

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http://dx.doi.org/10.1159/000494326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615339PMC
June 2019
3 Reads

Ultrasonography and transillumination for uveal melanoma localisation in proton beam treatment planning.

Eye (Lond) 2019 12 5;33(12):1904-1910. Epub 2019 Jul 5.

Department of Ophthalmology & Vision Science, University of California Davis Health Eye Centre, Sacramento, CA, USA.

Background/objective: The success of proton beam treatment (PBT) in uveal melanoma depends in part on the accuracy of tumour localisation. This study determined if using ultrasonography (US) to measure the distance between tumour margin and tantalum ring (DTR) in PBT planning improves local treatment success when compared with using intraoperative transillumination (TI) alone.

Methods: Retrospective analysis of patients with uveal melanoma treated at one centre between January 2006 and June 2017 with ≥12-month follow-up (or until treatment failure). Read More

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http://dx.doi.org/10.1038/s41433-019-0512-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002621PMC
December 2019
3 Reads
1.897 Impact Factor

Ciliochoroidal melanoma presenting as bleeding anterior staphyloma: Report of a case and review of literature.

Indian J Ophthalmol 2019 07;67(7):1162-1163

Orbit, Oculoplasty, Reconstructive and Aesthetic Services, Sankara Nethralaya, Medical Research Foundation, Chennai, Tamil Nadu, India.

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http://dx.doi.org/10.4103/ijo.IJO_1559_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611270PMC
July 2019
4 Reads

[Excision and tectonic covering of a vascular leiomyoma of the ciliary body with large anterior staphyloma using scleral patch graft].

Ophthalmologe 2020 Mar;117(3):270-276

Zentrum für Augenheilkunde, Universität zu Köln, Kerpener Str. 62, 50924, Köln, Deutschland.

Benign tumors of the ciliary body are rare and may potentially be confused with uveal melanoma in clinical routine. Clinical findings rarely allow for safe differentiation. Hence primary excisions are frequent. Read More

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http://dx.doi.org/10.1007/s00347-019-0919-xDOI Listing
March 2020
11 Reads

Intravitreal air bubble during exoresection of an iris-ciliary body melanoma.

Surg Oncol 2019 Jun 14;29:157-158. Epub 2019 May 14.

Oculoplastics-Orbit and Ocular Oncology Units, Department of Ophthalmology, Virgen Macarena University Hospital, Seville, Spain; RETICS OftaRed, Institute of Health Carlos III, Madrid, Spain. Electronic address:

In this manuscript, as members of a National Reference Unit in Ocular Oncology, we present succinctly our preferred surgical technique for iris-ciliary body melanomas. We attach a video describing the steps we usually follow [Video Clip 1], in which an impressive image of an intravitreal air bubble through the hyaloid membrane can be observed [Fig. 1]. Read More

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http://dx.doi.org/10.1016/j.suronc.2019.05.008DOI Listing
June 2019
7 Reads

Tectonic Keratoplasty to Restore the Bulbar Wall after Block Excision of Benign and Malignant Intraocular Tumors.

J Ophthalmol 2019 2;2019:4153064. Epub 2019 May 2.

Department of Ophthalmology, "Misericordia" Hospital, Grosseto, Italy.

Purpose: To report the surgical treatment and follow-up of tumors of the anterior uvea and epithelial cysts of the anterior chamber in 4 patients submitted to block excision and tectonic corneal graft between 2008 and 2012.

Methods: This is a retrospective, nonrandomized case series. Two patients were affected by anterior uveal malignant melanoma, and 2 patients were referred to us for large epithelial iris cysts with anterior chamber angle involvement and partial corneal failure. Read More

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http://dx.doi.org/10.1155/2019/4153064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525849PMC
May 2019
13 Reads

Diagnostic dilemma of ocular lymphoma.

BMJ Case Rep 2019 Jun 6;12(6). Epub 2019 Jun 6.

Singleton Hospital, Swansea, UK.

We report a very unusual presentation of primary intraocular lymphoma masquerading as anterior uveitis with atypical symptoms. A 68-year-old man, initially presented with a 4-day history of painless, left blurred vision. Examination revealed 2 or more anterior chamber cells, mutton-fat keratic precipitates and posterior synechiae. Read More

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http://dx.doi.org/10.1136/bcr-2019-229513DOI Listing
June 2019
16 Reads

Uveal melanoma: physiopathology and new in situ-specific therapies.

Cancer Chemother Pharmacol 2019 07 11;84(1):15-32. Epub 2019 May 11.

Department of Biology and Environment, University of Trás-os-Montes e Alto Douro, UTAD, Quinta de Prados, 5001-801, Vila Real, Portugal.

Uveal melanoma is the most common primary intraocular tumor in adults. It can arise from melanocytes in the anterior (iris) or posterior uveal tract (choroid and ciliary body). Uveal melanoma has a particular molecular pathogenesis, being characterized by specific chromosome alterations and gene mutations (e. Read More

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http://link.springer.com/10.1007/s00280-019-03860-z
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http://dx.doi.org/10.1007/s00280-019-03860-zDOI Listing
July 2019
22 Reads

Novel Eye Plaque Designs for Brachytherapy of Iris and Ciliary Body Melanoma and the First Clinical Application.

Ocul Oncol Pathol 2019 Apr 11;5(3):220-227. Epub 2018 Oct 11.

Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA.

Background: While traditional eye plaque brachytherapy can be used for the treatment of iris melanoma, it faces challenges of poor patient tolerability due to cornea-plaque touch caused by radius of curvature mismatch and potential dosimetric inaccuracy from incomplete coverage. We present novel plaque designs and the first clinical application of the plaques for iris melanoma.

Methods: Two dome-shaped plaques (EP2132 and EP1930) were designed to vault above the cornea to treat tumors of the iris and ciliary body. Read More

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http://dx.doi.org/10.1159/000493269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489066PMC
April 2019
13 Reads

Next-Generation Sequencing of Uveal Melanoma for Detection of Genetic Alterations Predicting Metastasis.

Transl Vis Sci Technol 2019 Mar 17;8(2):18. Epub 2019 Apr 17.

Hellen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.

Purpose: To clinically use the UCSF500, a pancancer, next-generation sequencing assay in uveal melanoma (UM) and to correlate results with gene expression profiling (GEP) and predictive factors for metastasis.

Methods: Cohort study. Tumor samples of adult UM patients were analyzed with the UCSF500 and GEP. Read More

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http://tvst.arvojournals.org/article.aspx?doi=10.1167/tvst.8
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http://dx.doi.org/10.1167/tvst.8.2.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472431PMC
March 2019
14 Reads

Hemorrhagic occlusive retinal vasculitis leading to the diagnosis of ciliary body melanoma.

Saudi J Ophthalmol 2019 Jan-Mar;33(1):81-83. Epub 2018 Sep 24.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

Hemorrhagic occlusive retinal vasculitis (HORV) is a condition associated with intraocular vancomycin during surgical intervention, most frequently following bilateral sequential cataract surgery. Because of the high rate of ophthalmic vascular complications in this condition, gonioscopic evaluation for identification of neovascularization of the angle and iris is essential. Careful examination can reveal previously asymptomatic and unassociated lesions of the iris or ciliary body. Read More

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http://dx.doi.org/10.1016/j.sjopt.2018.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424716PMC
September 2018
7 Reads

Pseudomelanoma (with Cataract) in a Child Caused by Amniocentesis.

Ophthalmology 2019 04;126(4):590

Memorial Sloan Kettering Cancer Center, New York, New York.

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https://linkinghub.elsevier.com/retrieve/pii/S01616420193017
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http://dx.doi.org/10.1016/j.ophtha.2019.01.025DOI Listing
April 2019
8 Reads

[Rapidly progressing cataract in contact with ciliary body melanoma after proton-beam irradiation].

J Fr Ophtalmol 2019 Mar 2;42(3):e115-e116. Epub 2019 Mar 2.

Service d'ophtalmologie, institut Curie, PSL Research University, 26, rue d'Ulm, 75005 Paris, France.

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http://dx.doi.org/10.1016/j.jfo.2018.06.020DOI Listing
March 2019
12 Reads

[Clinico-echographic diagnostics of iris tumors].

Ophthalmologe 2019 Apr;116(4):313-323

Zentrum für Augenheilkunde, Uniklinik Köln, Kerpener Str. 62, 50924, Köln, Deutschland.

Background: The differentiation of iridic space-occupying lesions represents a regularly reoccurring diagnostic challenge.

Objective: This article presents an overview of the epidemiological data and describes the diagnostic procedure for iris tumors.

Material And Methods: The article provides a review of the literature from PubMed and own clinical results. Read More

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http://dx.doi.org/10.1007/s00347-019-0861-yDOI Listing
April 2019
12 Reads

The Lens Opacities Classification System III Grading in Irradiated Uveal Melanomas to Characterize Proton Therapy-Induced Cataracts.

Am J Ophthalmol 2019 05 2;201:63-71. Epub 2019 Feb 2.

Department of Radiation Oncology. Centre Francois Baclesse / ARCHADE - Normandie Université, Caen, France. Electronic address:

Purpose: To evaluate the use of the Lens Opacities Classification System III grading (LOCS III) for the characterization of radiation-induced cataract, and to correlate the proton beam projection onto the lens with cataract location and grade as defined by the LOCS III.

Design: Prospective, interventional case series.

Methods: Fifty-two consecutive patients with cataract following proton therapy were included. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.025DOI Listing
May 2019
1 Read

Outcomes of Glaucoma Drainage Device Surgery in Eyes with Treated Uveal Melanoma.

Ocul Oncol Pathol 2019 Jan 2;5(1):20-27. Epub 2018 May 2.

Stein Eye and Doheny Eye Institutes, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Aim: We report patient safety and intraocular pressure (IOP) control after placement of a glaucoma drainage device (GDD) in eyes with a history of treated malignant uveal melanoma.

Methods: A retrospective review of the records of patients with uveal melanoma was performed. Outcomes were local tumor recurrence, rate of metastases, and to-nometric success, based on survival curves, defined as IOP < 21 mm Hg. Read More

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https://www.karger.com/Article/FullText/488056
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http://dx.doi.org/10.1159/000488056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341335PMC
January 2019
29 Reads

Iris melanoma relapsing sixteen years after proton-beam therapy: The importance of lifelong follow-up.

Am J Ophthalmol Case Rep 2019 Mar 6;13:89-92. Epub 2018 Dec 6.

Institut Curie, PSL Research University, Department of Ophthalmology, F-75005, Paris, France.

Purpose: To report a case of locally recurrent spindle-cell iris amelanotic melanoma 16 years after proton-beam therapy.

Observations: In 2001, a 45-year-old man presented with an amelanotic iris melanoma, extending from the 5 to 10 o'clock positions on his left eye. High-frequency ultrasonography showed extension of melanoma into the ciliary body. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305799PMC
March 2019
8 Reads

Two Uveal Melanomas in One Eye: A Choroidal Nevus Giving Rise to a Melanoma in an Eye with a Separate Large Choroidal Melanoma.

Ocul Oncol Pathol 2018 Nov 2;4(6):355-358. Epub 2018 Mar 2.

Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Multifocal uveal melanomas are extremely rare. In this case report, we describe a patient with 2 independent uveal melanomas in the same eye. A 52-year-old woman presented with a large choroidal melanoma and a smaller ciliary body mass, clinically thought to be a nevus, in her left eye. Read More

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http://dx.doi.org/10.1159/000486682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288664PMC
November 2018
9 Reads

Glaucoma secondary to intraocular tumors: mechanisms and management.

Curr Opin Ophthalmol 2019 Mar;30(2):71-81

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose Of Review: Glaucoma secondary to intraocular tumors is important to consider in eyes with a known tumor and those with unilateral or refractory glaucoma. The purpose of this review is to discuss the mechanisms and management of intraocular tumors with related secondary glaucoma.

Recent Findings: Several intraocular tumors can lead to glaucoma, including iris melanoma, iris metastasis, iris lymphoma, trabecular meshwork melanoma, choroidal melanoma, choroidal metastasis, retinoblastoma, and medulloepithelioma. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000550DOI Listing
March 2019
36 Reads

Ciliary body melanoma treatment by stereotactic radiosurgery.

Cesk Slov Oftalmol Spring 2018;73(5-6):204-210

Introduction: Malignant melanoma of the ciliary body (corpus ciliare) represents 10 to 15 percent of tumors of the uveal tract. The aim of the work is to evaluate the effectiveness of stereotactic radiosurgery performed on LINAC linear accelerator and the occurrence of postoperative complications.

Material And Methods: Retrospective analysis of patients with ciliary body melanoma treated with stereotactic radiosurgery on linear accelerator in the period 1/2011 to 12/2016 in Slovakia. Read More

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May 2019
7 Reads

[New treatment options for iridociliary tumors].

Ophthalmologe 2019 Apr;116(4):332-339

Zentrum für Augenheilkunde, Universität zu Köln, Kerpener Str. 62, 50924, Köln, Deutschland.

Background: Benign iridal tumors rarely necessitate a therapeutic intervention. In contrast, malignant tumors of the iris can threaten the patient's life and eyesight and require early treatment to prevent the development of metastases.

Objective: Presentation of current treatment options for iridal tumors with special emphasis on iridal melanoma. Read More

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http://dx.doi.org/10.1007/s00347-018-0825-7DOI Listing
April 2019
12 Reads

Posterior uveal melanoma in adolescents and children: current perspectives.

Clin Ophthalmol 2018 7;12:2205-2212. Epub 2018 Nov 7.

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA,

Recognizing that <1% of all uveal melanomas occur in young persons, and that very few clinicians encounter more than a few such cases over an extended career, we felt that a retrospective review of literature and sharing of our clinical experience would be appropriate to remind readers about this age subgroup of patients with posterior uveal melanoma. This interest stems from the increase in reported cases of uveal melanoma in younger individuals and recent advances in the field. Read More

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http://dx.doi.org/10.2147/OPTH.S142984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6228084PMC
November 2018
26 Reads