1,219 results match your criteria Melanoma Ciliary Body


Hemorrhagic occlusive retinal vasculitis leading to the diagnosis of ciliary body melanoma.

Saudi J Ophthalmol 2019 Jan-Mar;33(1):81-83. Epub 2018 Sep 24.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

Hemorrhagic occlusive retinal vasculitis (HORV) is a condition associated with intraocular vancomycin during surgical intervention, most frequently following bilateral sequential cataract surgery. Because of the high rate of ophthalmic vascular complications in this condition, gonioscopic evaluation for identification of neovascularization of the angle and iris is essential. Careful examination can reveal previously asymptomatic and unassociated lesions of the iris or ciliary body. Read More

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http://dx.doi.org/10.1016/j.sjopt.2018.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424716PMC
September 2018
1 Read

[Rapidly progressing cataract in contact with ciliary body melanoma after proton-beam irradiation].

J Fr Ophtalmol 2019 Mar 2;42(3):e115-e116. Epub 2019 Mar 2.

Service d'ophtalmologie, institut Curie, PSL Research University, 26, rue d'Ulm, 75005 Paris, France.

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http://dx.doi.org/10.1016/j.jfo.2018.06.020DOI Listing
March 2019
6 Reads

[Clinico-echographic diagnostics of iris tumors].

Ophthalmologe 2019 Apr;116(4):313-323

Zentrum für Augenheilkunde, Uniklinik Köln, Kerpener Str. 62, 50924, Köln, Deutschland.

Background: The differentiation of iridic space-occupying lesions represents a regularly reoccurring diagnostic challenge.

Objective: This article presents an overview of the epidemiological data and describes the diagnostic procedure for iris tumors.

Material And Methods: The article provides a review of the literature from PubMed and own clinical results. Read More

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http://dx.doi.org/10.1007/s00347-019-0861-yDOI Listing
April 2019
2 Reads

Outcomes of Glaucoma Drainage Device Surgery in Eyes with Treated Uveal Melanoma.

Ocul Oncol Pathol 2019 Jan 2;5(1):20-27. Epub 2018 May 2.

Stein Eye and Doheny Eye Institutes, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Aim: We report patient safety and intraocular pressure (IOP) control after placement of a glaucoma drainage device (GDD) in eyes with a history of treated malignant uveal melanoma.

Methods: A retrospective review of the records of patients with uveal melanoma was performed. Outcomes were local tumor recurrence, rate of metastases, and to-nometric success, based on survival curves, defined as IOP < 21 mm Hg. Read More

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https://www.karger.com/Article/FullText/488056
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http://dx.doi.org/10.1159/000488056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341335PMC
January 2019
9 Reads

Iris melanoma relapsing sixteen years after proton-beam therapy: The importance of lifelong follow-up.

Am J Ophthalmol Case Rep 2019 Mar 6;13:89-92. Epub 2018 Dec 6.

Institut Curie, PSL Research University, Department of Ophthalmology, F-75005, Paris, France.

Purpose: To report a case of locally recurrent spindle-cell iris amelanotic melanoma 16 years after proton-beam therapy.

Observations: In 2001, a 45-year-old man presented with an amelanotic iris melanoma, extending from the 5 to 10 o'clock positions on his left eye. High-frequency ultrasonography showed extension of melanoma into the ciliary body. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305799PMC
March 2019
1 Read

Two Uveal Melanomas in One Eye: A Choroidal Nevus Giving Rise to a Melanoma in an Eye with a Separate Large Choroidal Melanoma.

Ocul Oncol Pathol 2018 Nov 2;4(6):355-358. Epub 2018 Mar 2.

Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Multifocal uveal melanomas are extremely rare. In this case report, we describe a patient with 2 independent uveal melanomas in the same eye. A 52-year-old woman presented with a large choroidal melanoma and a smaller ciliary body mass, clinically thought to be a nevus, in her left eye. Read More

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http://dx.doi.org/10.1159/000486682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288664PMC
November 2018
2 Reads

Glaucoma secondary to intraocular tumors: mechanisms and management.

Curr Opin Ophthalmol 2019 Mar;30(2):71-81

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose Of Review: Glaucoma secondary to intraocular tumors is important to consider in eyes with a known tumor and those with unilateral or refractory glaucoma. The purpose of this review is to discuss the mechanisms and management of intraocular tumors with related secondary glaucoma.

Recent Findings: Several intraocular tumors can lead to glaucoma, including iris melanoma, iris metastasis, iris lymphoma, trabecular meshwork melanoma, choroidal melanoma, choroidal metastasis, retinoblastoma, and medulloepithelioma. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000550DOI Listing
March 2019
13 Reads

Ciliary body melanoma treatment by stereotactic radiosurgery.

Cesk Slov Oftalmol Spring 2018;73(5-6):204-210

Introduction: Malignant melanoma of the ciliary body (corpus ciliare) represents 10 to 15 percent of tumors of the uveal tract. The aim of the work is to evaluate the effectiveness of stereotactic radiosurgery performed on LINAC linear accelerator and the occurrence of postoperative complications.

Material And Methods: Retrospective analysis of patients with ciliary body melanoma treated with stereotactic radiosurgery on linear accelerator in the period 1/2011 to 12/2016 in Slovakia. Read More

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December 2018
3 Reads

[New treatment options for iridociliary tumors].

Ophthalmologe 2019 Apr;116(4):332-339

Zentrum für Augenheilkunde, Universität zu Köln, Kerpener Str. 62, 50924, Köln, Deutschland.

Background: Benign iridal tumors rarely necessitate a therapeutic intervention. In contrast, malignant tumors of the iris can threaten the patient's life and eyesight and require early treatment to prevent the development of metastases.

Objective: Presentation of current treatment options for iridal tumors with special emphasis on iridal melanoma. Read More

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http://dx.doi.org/10.1007/s00347-018-0825-7DOI Listing
April 2019
4 Reads

Posterior uveal melanoma in adolescents and children: current perspectives.

Clin Ophthalmol 2018 7;12:2205-2212. Epub 2018 Nov 7.

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA,

Recognizing that <1% of all uveal melanomas occur in young persons, and that very few clinicians encounter more than a few such cases over an extended career, we felt that a retrospective review of literature and sharing of our clinical experience would be appropriate to remind readers about this age subgroup of patients with posterior uveal melanoma. This interest stems from the increase in reported cases of uveal melanoma in younger individuals and recent advances in the field. Read More

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http://dx.doi.org/10.2147/OPTH.S142984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6228084PMC
November 2018
12 Reads

Uveal melanoma survival rates after single dose stereotactic radiosurgery.

Neoplasma 2018 Nov 4;65(6):965-971. Epub 2018 Sep 4.

Department of Ophthalmology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

This paper presents the long-term results of single dose stereotactic radiosurgery for intraocular uveal malignant melanoma, and summarizes the results of the retrospective study in 170 Slovak patients. A group of uveal melanoma patients (149 choroidal melanoma, 21 ciliary body melanoma) from 20 to 92 years of age with 59 year median were treated in 2001-2016. There were 81males (47. Read More

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http://dx.doi.org/10.4149/neo_2018_171209N808DOI Listing
November 2018
2 Reads

20-year assessment of metastatic latency and subsequent time to death after proton therapy for uveal melanomas.

Melanoma Res 2018 Oct 12. Epub 2018 Oct 12.

Department of Ophthalmology, Croix-Rousse University Hospital.

The aim of this study was to evaluate metastatic latency and survival after the occurrence of metastases in patients with choroidal/ciliary body melanoma treated with proton therapy. This was a retrospective cohort study. All consecutive patients with choroidal/ciliary body melanoma treated with proton therapy between 1991 and 2010 were included. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000519DOI Listing
October 2018

Melanoma or glaucoma? A case report.

Arch Soc Esp Oftalmol 2018 Dec 27;93(12):610-612. Epub 2018 Sep 27.

Sección de Glaucoma, FISABIO Oftalmología Médica, Valencia, España.

Case Report: The case is presented of a patient referred to us with suspicion of a ciliary body melanoma due to a pigmented lesion in iris root of left eye, associated with high intraocular pressure, despite maximal topical and systemic medication. The systematic workup revealed unilateral changes in the corneal endothelium, compatible with an iridocorneal syndrome. An Ahmed valve was inserted, achieving sustained control of intraocular pressure and visual field defects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03656691183018
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http://dx.doi.org/10.1016/j.oftal.2018.06.002DOI Listing
December 2018
2 Reads

Radiobiological doses, tumor, and treatment features influence on local control, enucleation rates, and survival after epiescleral brachytherapy. A 20-year retrospective analysis from a single-institution: part I.

J Contemp Brachytherapy 2018 Aug 31;10(4):337-346. Epub 2018 Aug 31.

Intraocular Tumor Unit, Hospital Universitario de Valladolid, Valladolid.

Purpose: To assess influence of the radiobiological doses, tumor, and treatment features on local control, enucleation rates, overall and disease-specific survival rates after brachytherapy for posterior uveal melanoma.

Material And Methods: Local control, enucleation, overall and disease-specific survival rates were evaluated on the base of 243 patients from 1996 through 2016, using plaques loaded with iodine sources. Clinical and radiotherapy data were extracted from a dedicated prospective database. Read More

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http://dx.doi.org/10.5114/jcb.2018.77849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142652PMC
August 2018
11 Reads

Case Report: Importance of B-scan Ultrasonography for the Detection of Choroidal Melanoma.

Optom Vis Sci 2018 Oct;95(10):971-974

Murray Ocular Oncology and Retina, Miami, Florida

Significance: This case highlights the importance of using ultrasonography to evaluate an eye that has no clear view of the fundus.

Purpose: Uveal melanoma stems from melanocytes found in the iris, ciliary body, and choroid, and it is the most common primary intraocular malignancy found in adults. The lesion is identified predominantly via fundus biomicroscopy and binocular indirect ophthalmoscopy. Read More

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http://dx.doi.org/10.1097/OPX.0000000000001287DOI Listing
October 2018
3 Reads

Uveal Metastasis: Clinical Features and Survival Outcome of 2214 Tumors in 1111 Patients Based on Primary Tumor Origin.

Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):81-90

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: The purpose of this study is to evaluate patients with uveal metastasis based on primary tumor site.

Methods: Retrospective analysis from Wills Eye Hospital, Philadelphia, PA, USA, for uveal metastasis clinical features and outcomes based on the primary tumor site.

Results: There were 2214 uveal metastases diagnosed in 1111 consecutive patients. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_6_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071342PMC
September 2018
12 Reads

Do Largest Basal Tumor Diameter and the American Joint Committee on Cancer's Cancer Staging Influence Prognostication by Gene Expression Profiling in Choroidal Melanoma.

Am J Ophthalmol 2018 Nov 4;195:83-92. Epub 2018 Aug 4.

Department of Ophthalmology and Visual Sciences, Yale University, New Haven, Connecticut, USA.

Purpose: To evaluate the prognostication of choroidal melanoma (CM) by the gene expression profiling (GEP) test.

Design: Cohort study.

Methods: Retrospective review of 293 CM patients from 2 centers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183042
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http://dx.doi.org/10.1016/j.ajo.2018.07.033DOI Listing
November 2018
8 Reads

Upregulation of BCL2 19 kD Protein-Interacting Protein 3 (BNIP3) is Predictive of Unfavorable Prognosis in Uveal Melanoma.

Med Sci Monit 2018 Jul 8;24:4711-4717. Epub 2018 Jul 8.

Department of Gynecology and Obstetrics, LinYi Central Hospital, Shandong, China (mainland).

BACKGROUND BCL2 19 kD protein-interacting protein 3 (BNIP3) is a BH3-containing protein of the BCL-2 family; it can regulate cell death, autophagy, and cytoprotection. The upregulation of BNIP3 has been reported to relate to progression and poor prognosis in different cancer types. However, the clinical significance of BNIP3 in uveal melanoma (UM) is still unknown. Read More

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http://dx.doi.org/10.12659/MSM.907679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070000PMC
July 2018
4 Reads

Distinguishing midzonal iris pigment epithelial cyst from adenoma and ciliary body melanoma.

Oman J Ophthalmol 2018 May-Aug;11(2):161-163

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

A 49-year old male with corrected visual acuity of 20/25 OD and 20/20 OS was found to have an asymptomatic dark iris mass OD with suspicion for ciliary body melanoma. Predilation slit-lamp biomicroscopy revealed a well-circumscribed brown round mass arising posterior to the iris, presumably from the ciliary body; however, postdilation demonstrated an extended fusiform mass of the iris pigment epithelium (IPE). By anterior segment imaging, the well-circumscribed IPE mass was cystic and measured 1440 microns in thickness peripherally predilation and 300 microns in thickness postdilation. Read More

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http://dx.doi.org/10.4103/ojo.OJO_226_2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991049PMC
June 2018
3 Reads

Rosai-Dorfman disease masquerading as Uveal Melanoma: Case report and review of literature.

Hematol Oncol Stem Cell Ther 2018 Jun 15. Epub 2018 Jun 15.

Department of Surgery, King Hussein Cancer Center, Amman, Jordan.

Objective/background: Intra ocular Rosai-Dorfman disease (RDD) is an extremely rare disease. We are reporting the first case of RDD presenting as ciliary body mass mimicking ciliary body melanoma, and we are reviewing the English literature reporting on cases of RDD presented with intraocular disease.

Methods: An 18-year-old lady presented with loss of vision in the right eye, and was found to have intraocular mass lesion. Read More

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http://dx.doi.org/10.1016/j.hemonc.2018.05.005DOI Listing
June 2018
6 Reads

Neoadjuvant proton beam irradiation vs. adjuvant ruthenium brachytherapy in transscleral resection of uveal melanoma.

Graefes Arch Clin Exp Ophthalmol 2018 Sep 16;256(9):1767-1775. Epub 2018 Jun 16.

Department of Ophthalmology, Medical University Innsbruck, Innsbruck, Austria.

Background: Uveal melanoma is the most common primary ocular malignancy in adults in the USA and Europe. The optimal treatment of large uveal melanoma is still under debate. Radiation therapy has its limitation due its eye-threatening secondary complications and is therefore often combined with surgical excision of the tumor. Read More

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http://dx.doi.org/10.1007/s00417-018-4032-7DOI Listing
September 2018

Clinical and pathological correlation of cotton wool spots in secondary angle closure glaucoma.

Am J Ophthalmol Case Rep 2018 Jun 28;10:192-195. Epub 2018 Feb 28.

University of California, Gavin Herbert Eye Institute, Irvine, CA, USA.

Purpose: Cotton Wool Spots (CWS) are a commonly described retinal finding in the posterior segment associated with an extensive number of systemic diseases. The appearance of a CWS in the setting of glaucoma has rarely been reported and has not been correlated with pathology to localized loss of the nerve fiber layer previously. In this case report, we augment a previous report of an 18 year old female with a diagnosis of low grade ciliary body melanoma. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.02.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956715PMC
June 2018
28 Reads

Advanced Midzonal Iris Pigment Epithelial Cyst Managed by Aspiration Deflation.

Ocul Oncol Pathol 2018 Apr 9;4(3):182-185. Epub 2017 Nov 9.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

Background: There are several cysts that can occur in the iris. The midzonal (retroiridic) iris pigment epithelial (IPE) cyst is important because it can simulate melanoma of the ciliary body. However, it is frequently asymptomatic and requires no treatment. Read More

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http://dx.doi.org/10.1159/000481405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939718PMC
April 2018
1 Read

Uveal Melanoma: 5-Year Update on Incidence, Treatment, and Survival (SEER 1973-2013).

Ocul Oncol Pathol 2018 Apr 13;4(3):145-151. Epub 2017 Oct 13.

Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.

Purpose: To analyze trends in incidence, treatment, and survival of uveal melanoma in the United States from 1973 to 2013 using the Surveillance, Epidemiology, and End Results database.

Materials And Methods: Patients were identified using International Classification of Disease for Oncology codes: C69.3 (choroid), C69. Read More

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http://dx.doi.org/10.1159/000480640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939716PMC
April 2018
2 Reads

Proton Beam Irradiation: A Safe Procedure in Postequatorial Extraocular Extension From Uveal Melanoma.

Am J Ophthalmol 2018 Jul 12;191:49-53. Epub 2018 Apr 12.

Department of Ophthalmology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Purpose: This study was performed to show long-term outcomes concerning metastasis rates and local recurrence rates after primary proton beam therapy in uveal melanoma with posterior extraocular extension (EOE) with the main focus on optic nerve invasion.

Design: Retrospective case series.

Methods: All patients treated with primary proton beam therapy for choroidal or ciliary body melanoma with posterior EOE between July 1998 and August 2010 were included. Read More

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http://dx.doi.org/10.1016/j.ajo.2018.04.006DOI Listing
July 2018
7 Reads

Immune privilege: failure of immunotherapy in controlling metastatic cutaneous melanoma to the eye.

Melanoma Res 2018 08;28(4):359-362

Moorfields Eye Hospital.

This report concerns a 49-year-old female with cutaneous malignant melanoma and systemic metastases. These resolved following combination immunotherapy with ipilimumab and nivolumab. She subsequently experienced unilateral floaters, an increase in iris pigmentation and pigmentary glaucoma. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000443DOI Listing
August 2018
10 Reads
2.282 Impact Factor

Yield, Techniques, and Complications of Transvitreal and Transscleral Biopsies in Small Uveal Melanoma.

JAMA Ophthalmol 2018 May;136(5):482-488

Retina Consultants of Houston, Houston, Texas.

Importance: Intraoperative adequacy check of biopsy samples can lead to a higher biopsy yield rate, and subsequent genomic analysis can provide patients with valuable prognostic information.

Objectives: To examine the yield rates for transscleral and transvitreal fine-needle aspiration biopsies of small uveal melanoma less than 3.6 mm in apical height and to discuss techniques that would maximize yield rates and minimize complications. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2018.0561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876837PMC

RELATIONSHIP OF CLINICAL FEATURES AND BASELINE TUMOR SIZE WITH GENE EXPRESSION PROFILE STATUS IN UVEAL MELANOMA: A Multi-institutional Study.

Retina 2018 Mar 23. Epub 2018 Mar 23.

Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas.

Purpose: To study the relationship between gene expression profile subclass and clinical features in a multicenter cohort of patients with uveal melanoma.

Methods: A retrospective, multicenter study was undertaken with patients entered from nine major ocular oncology centers from across the United States. Eligible patients had uveal melanoma and underwent I-125 plaque brachytherapy with concurrent tumor biopsy with gene expression profile testing between January 1, 2010, and October 28, 2014. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002113DOI Listing
March 2018
3 Reads

Clinical Predictors of Regression of Choroidal Melanomas after Brachytherapy: A Growth Curve Model.

Ophthalmology 2018 May 2;125(5):747-754. Epub 2018 Mar 2.

Ocular Oncology Service, Department of Ophthalmology University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Purpose: To build multivariate models to assess correctly and efficiently the contribution of tumor characteristics on the rate of regression of choroidal melanomas after brachytherapy in a way that adjusts for confounding and takes into account variation in tumor regression patterns.

Design: Modeling of longitudinal observational data.

Participants: Ultrasound images from 330 of 388 consecutive choroidal melanomas (87%) irradiated from 2000 through 2008 at the Helsinki University Hospital, Helsinki, Finland, a national referral center. Read More

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http://dx.doi.org/10.1016/j.ophtha.2018.01.032DOI Listing
May 2018
5 Reads

Optical coherence tomography angiography of a pigmented Fuchs' adenoma (age-related hyperplasia of the nonpigmented ciliary body epithelium) masquerading as a ciliary body melanoma.

Am J Ophthalmol Case Rep 2018 Mar 10;9:72-74. Epub 2018 Jan 10.

Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA.

Purpose: To report a case of age-related hypertrophy of the nonpigmented ciliary epithelium (ARH-NPCE) clinically resembling a ciliary body melanoma and report the optical coherence tomography angiography (OCTA) findings associated with this lesion.

Observations: A 51-year-old male was referred for evaluation of a deeply pigmented ciliary body mass with extension through the iris root. Iridocyclectomy was performed due to concern for ciliary body melanoma. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786886PMC
March 2018
12 Reads

Metastatic uveal melanoma showing durable response to anti-CTLA-4 and anti-PD-1 combination therapy after experiencing progression on anti-PD-1 therapy alone.

J Immunother Cancer 2018 Feb 12;6(1):13. Epub 2018 Feb 12.

Hematology/Oncology, Norris cotton Cancer Center, One Medical Center Dr., Lebanon, NH, 03756, USA.

Background: Uveal melanoma accounts for 85% of the ocular melanomas and has an increased risk of hematogenous spread, most commonly to the liver. After curative intent therapy like surgery and radiation, fifty percent of patients present with distant metastasis. Metastatic uveal melanoma (MUM) does not harbor typically targetable mutations, e. Read More

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https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0
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http://dx.doi.org/10.1186/s40425-018-0322-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809910PMC
February 2018
6 Reads

Genetic Background of Iris Melanomas and Iris Melanocytic Tumors of Uncertain Malignant Potential.

Ophthalmology 2018 Jun 19;125(6):904-912. Epub 2018 Jan 19.

Department of Ocular Oncology, The Rotterdam Eye Hospital, Rotterdam, The Netherlands; Department of Pathology, Section Ophthalmic Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address:

Purpose: Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Iris melanoma comprises 4% to 10% of all UMs and has a lower mortality rate. The genetic changes in iris melanoma are not as well characterized as ciliary body or choroidal melanoma. Read More

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http://dx.doi.org/10.1016/j.ophtha.2017.12.022DOI Listing
June 2018
15 Reads

Long-term uveal melanoma survivors: measuring their quality of life.

Acta Ophthalmol 2018 Jun 25;96(4):e421-e426. Epub 2018 Jan 25.

Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Purpose: Patients with uveal melanoma (UM) undergo lifelong follow-up as metastases can occur more than 20 years after diagnosis. Little is known about the quality of life (QoL) of UM survivors over such an extended period. To investigate their QoL, we used various estimating factors. Read More

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http://dx.doi.org/10.1111/aos.13655DOI Listing
June 2018
9 Reads

Acute Presentation of Mesectodermal Leiomyoma of the Ciliary Body.

Ocul Oncol Pathol 2017 Nov 21;3(4):304-309. Epub 2017 Apr 21.

Yale New Haven Hospital, New Haven, Connecticut, USA.

Purpose: We report a case of acutely presenting mesectodermal leiomyoma of the ciliary body in a 29-year-old female who reported waking up with swollen eyelids of the right eye and light-perception vision. The affected eye had elevated intraocular pressure, a flat anterior chamber, and a pale, round mass arising from the nasal ciliary body, invading the angle and protruding into the visual axis posterior to the lens. Within days, the visual acuity decreased to no light perception. Read More

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http://dx.doi.org/10.1159/000464466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757584PMC
November 2017
4 Reads

Retinoinvasive Uveal Melanoma: Report of 2 Cases and Review of the Literature.

Ocul Oncol Pathol 2017 Nov 14;3(4):292-295. Epub 2017 Apr 14.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.

Purpose: To describe the clinical history and histopathologic findings of 2 cases of retinoinvasive uveal melanoma.

Methods: The medical records and pathology specimens of 2 patients with retinoinvasive uveal melanoma were reviewed.

Results: The first patient had an iris/ciliary body melanoma that was treated and the second patient had suspected iridocorneal endothelial syndrome. Read More

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http://dx.doi.org/10.1159/000468940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757583PMC
November 2017
6 Reads

Ring-Shaped Leiomyoma of the Ciliary Body.

Ocul Oncol Pathol 2017 Nov 24;3(4):250-253. Epub 2017 Mar 24.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.

Purpose: Ciliary body mesectodermal leiomyoma is a rare, benign smooth muscle tumor that typically presents in women in the second to fourth decade of life. The diagnosis is typically based on clinical color, funduscopic appearance, transillumination properties, and B-scan ultrasonography.

Methods: We present a patient with a 360° ciliary body mass with transillumination and ultrasonographic properties consistent with a ring melanoma. Read More

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http://dx.doi.org/10.1159/000464249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757545PMC
November 2017
5 Reads

Outcomes of primary endoresection for choroidal melanoma.

Int J Retina Vitreous 2017 6;3:42. Epub 2017 Nov 6.

Department of Ophthalmology and Visual Sciences, Federal University of São Paulo, São Paulo, Brazil.

Purpose: To review long time treatment results in patients with small or medium sized choroidal melanoma who underwent surgical tumor endoresection as a primary treatment when plaque radiotherapy was unable and patients declined enucleation.

Materials And Methods: Patients were evaluated for best corrected visual acuity (BCVA), and underwent biomicroscopy, indirect ophthalmoscopy, retinography and ultrasound as well as the usual systemic workup. Study inclusion required the absence of scleral invasion or metastasis and an anterior margin not exceeding the pars plana or the ciliary body. Read More

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http://dx.doi.org/10.1186/s40942-017-0096-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674241PMC
November 2017
5 Reads

Ruthenium-106 brachytherapy for iris and iridociliary melanomas.

Br J Ophthalmol 2018 08 9;102(8):1154-1159. Epub 2017 Nov 9.

Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands.

Background And Purpose: To evaluate ruthenium-106 (Ru106) brachytherapy as eye-conserving treatment of iris melanomas (IMs) and iridociliary melanomas (ICMs).

Materials And Methods: Eighty-eight patients received Ru106 brachytherapy between 2006 and 2016. Primary outcome was local control, and secondary outcomes were metastasis, survival, eye preservation, complications and visual acuity (VA). Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2017-3106
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http://dx.doi.org/10.1136/bjophthalmol-2017-310688DOI Listing
August 2018
13 Reads

SOX10 Expression as Well as BRAF and GNAQ/11 Mutations Distinguish Pigmented Ciliary Epithelium Neoplasms From Uveal Melanomas.

Invest Ophthalmol Vis Sci 2017 10;58(12):5445-5451

Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.

Purpose: Adenocarcinomas or adenomas derived from pigmented ciliary epithelium (APCE) are exceptionally rare ocular tumors. These tumors have pigmented and epithelioid features, and some APCEs are negative for keratin markers and positive for melanocytic markers. It is especially difficult to distinguish APCEs from uveal melanoma (UM). Read More

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http://dx.doi.org/10.1167/iovs.17-22362DOI Listing
October 2017
51 Reads

[Ocular melanomas : An update].

Pathologe 2017 Nov;38(6):491-499

Liverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, Großbritannien.

Melanoma is the most common type of primary cancer to affect the adult eye. Approximately 95% of ocular melanomas are intraocular and arise from the uvea (i. e. Read More

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http://dx.doi.org/10.1007/s00292-017-0389-3DOI Listing
November 2017
2 Reads

Ciliary body melanoma manifesting as unilateral ocular hypertension and early cataract.

Clin Exp Optom 2018 03 11;101(2):305-307. Epub 2017 Oct 11.

Department of Ophthalmology, Gartnavel General Hospital, Glasgow, Scotland.

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http://dx.doi.org/10.1111/cxo.12610DOI Listing
March 2018
4 Reads

Palladium-103 plaque radiation therapy for ciliary body melanoma through a functioning glaucoma filtering bleb.

Eur J Ophthalmol 2018 Jan;28(1):119-122

1 Department of Ophthalmology, Ocular Tumor Service, The New York Eye and Ear Infirmary of Mount Sinai, New York, New York - USA.

Purpose: To provide a clinical description of the long-term outcome of a Pd plaque-irradiated ciliary body melanoma with extrascleral extension while attempting to preserve a subadjacent glaucoma filtering bleb.

Methods: A 75-year-old woman with pseudoexfoliative glaucoma for 17 years, 16 years status post argon laser trabeculoplasty, and 15 years status post trabeculectomy in the left eye, was diagnosed with an ipsilateral ciliary body melanoma with visible extrascleral extension. Treatment involved insertion of a Pd radioactive plaque over the functioning trabeculectomy, with removal 7 days later. Read More

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http://dx.doi.org/10.5301/ejo.5001046DOI Listing
January 2018
27 Reads

Uveal Melanoma Regression after Brachytherapy: Relationship with Chromosome 3 Monosomy Status.

Ocul Oncol Pathol 2017 Jul 29;3(2):87-94. Epub 2016 Oct 29.

Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Ohio, USA.

Aim: The objective was to evaluate the relationship between the regression rate of ciliary body melanoma and choroidal melanoma after brachytherapy and chromosome 3 monosomy status.

Methods: We conducted a prospective and consecutive case series of patients who underwent biopsy and brachytherapy for ciliary/choroidal melanoma. Tumor biopsy performed at the time of radiation plaque placement was analyzed with fluorescence in situ hybridization to determine the percentage of tumor cells with chromosome 3 monosomy. Read More

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https://www.karger.com/Article/FullText/451001
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http://dx.doi.org/10.1159/000451001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567042PMC
July 2017
33 Reads

[CyberKnife®: new treatment option for uveal melanoma].

Ophthalmologe 2018 04;115(4):302-308

Zentrum für Augenheilkunde, Universität zu Köln, Kerpener Str. 62, 50924, Köln, Deutschland.

Background: CyberKnife® stereotactic radiosurgery is a new treatment option for uveal melanoma.

Objective: This review outlines the technique of robot-assisted CyberKnife® therapy, as well as the pros and cons in the treatment of uveal melanoma.

Methods: The study provides a PubMed literature review and own preliminary clinical experiences. Read More

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http://dx.doi.org/10.1007/s00347-017-0560-5DOI Listing
April 2018
8 Reads

[Surgical Methods in the Treatment of Uveal Melanoma].

Klin Monbl Augenheilkd 2017 Jul 25;234(7):874-885. Epub 2017 Jul 25.

Universitätsklinik für Augenheilkunde und Optometrie, Medizinische Universität Innsbruck, Innsbruck, Österreich.

Significant advancements have been made in the last decades in the treatment of uveal melanoma. Radiation therapy can achieve, depending on the method, local tumour control in up to 98% of cases. Surgical modalities have been implemented in the ocular therapy for uveal melanoma either to treat/prevent radiation complications, such as so-called toxic tumour syndrome, or to primarily treat the tumour with or without adjunctive radiotherapy. Read More

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http://dx.doi.org/10.1055/s-0043-114421DOI Listing
July 2017
16 Reads

Neovascular glaucoma after proton beam therapy of choroidal melanoma: incidence and risk factors.

Graefes Arch Clin Exp Ophthalmol 2017 Nov 18;255(11):2263-2269. Epub 2017 Jul 18.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Department of Ophthalmology, Campus Benjamin Franklin, Berlin, Germany.

Purpose: To analyze the risk factors for the development of neovascular glaucoma (NVG) of patients with choroidal melanoma after proton beam therapy (PBT).

Method: Clinical case series, retrospective study. We evaluated 629 consecutive patients receiving proton beam therapy for the treatment of a choroidal melanoma at the oncology service at Charité, Berlin and Helmholtz-Zentrum, Berlin between 05/1998 and 11/2008 regarding the development and risk factors of NVG. Read More

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http://dx.doi.org/10.1007/s00417-017-3737-3DOI Listing
November 2017
8 Reads

Scleral Thinning Documented by Ultrasound Biomicroscopy after Plaque Therapy for Anterior Ciliary Melanoma.

Semin Ophthalmol 2018 13;33(4):571-575. Epub 2017 Jul 13.

a University Eye Clinic, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, University Hospital "Sveti Duh" , Zagreb , Croatia.

Purpose: To evaluate, by ultrasound biomicroscopy (UBM), changes in scleral thickness after ruthenium-106 CCB and CCC plaque (Eckert & Ziegler BE-BIG GmbH, Berlin, Germany) therapy for anterior ciliary melanoma.

Methods: Eleven patients with anterior ciliary melanoma underwent ruthenium-106 CCB and CCC plaque radiation with a radiation dose at the tumor apex of 80-100 Gy. UBM measurements performed prior to and after treatment were as follows: the largest prominence of the tumor perpendicular to the sclera and scleral thickness at scleral spur, 1. Read More

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http://dx.doi.org/10.1080/08820538.2017.1346131DOI Listing
June 2018
16 Reads

Frequent GNAQ, GNA11, and EIF1AX Mutations in Iris Melanoma.

Invest Ophthalmol Vis Sci 2017 07;58(9):3464-3470

Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK), Essen, Germany 8Dermatopathologie bei Mainz, Nieder-Olm, Germany.

Purpose: The most common malignant intraocular tumors with a high mortality in adults are uveal melanomas. Uveal melanomas arise most frequently in the choroid or ciliary body (97%) and rarely in the iris (3%). Whereas conjunctival and posterior uveal (ciliary body and choroidal) melanomas have been studied in more detail genetically, little data exist regarding iris melanomas. Read More

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http://dx.doi.org/10.1167/iovs.17-21838DOI Listing
July 2017
73 Reads

Iridociliary cysts masquerading as neoplasia in cats: a morphologic review of 14 cases.

Vet Ophthalmol 2018 Mar 6;21(2):125-131. Epub 2017 Jul 6.

Comparative Ocular Pathology Laboratory of Wisconsin, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.

Objective: To report 14 neoplasia-free feline eyes enucleated for suspected intraocular neoplasia containing only iridociliary cysts. To analyze clinical findings that may have led veterinarians to suspect neoplasia in these globes.

Procedures: The archives at the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) were searched to identify neoplasia-free feline globes enucleated for suspected neoplasia. Read More

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http://doi.wiley.com/10.1111/vop.12484
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http://dx.doi.org/10.1111/vop.12484DOI Listing
March 2018
7 Reads