3,335 results match your criteria Melanoma Choroidal


[Metastatic clear cell renal cell carcinoma: a potential mimicker of choroidal melanoma].

Magy Onkol 2022 Jun 1;66(2):157-161. Epub 2021 Jul 1.

Szemészeti Klinika, Semmelweis Egyetem, Budapest, Hungary.

While metastases are the most common intraocular malignancies, ocular metastases of renal cell carcinoma are rare. The most frequent primary malignancy of the eye is uveal melanoma. The common ocular localization is the choroid in both cases. Read More

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Potential of Aqueous Humor as a Liquid Biopsy for Uveal Melanoma.

Int J Mol Sci 2022 Jun 2;23(11). Epub 2022 Jun 2.

The Vision Center at Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.

Tumor biopsy can identify prognostic biomarkers for metastatic uveal melanoma (UM), however aqueous humor (AH) liquid biopsy may serve as an adjunct. This study investigated whether the AH of UM eyes has sufficient circulating tumor DNA (ctDNA) to perform genetic analysis. This is a case series of 37 AH samples, taken before or after radiation, and one tumor wash sample, from 12 choroidal and 8 ciliary body (CB) melanoma eyes. Read More

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Case Series: Presumed Choroidal Melanoma Diagnosis Expedited by Documented Growth on Serial Optical Coherence Tomography.

Optom Vis Sci 2022 Jun 9. Epub 2022 Jun 9.

Ocular Oncology Clinic, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia (RFJO'D, DMc, JDMc), Centre for Eye Research Australia (PvW), and Ophthalmology, Department of Surgery (PvW), University of Melbourne, Parkville, Victoria, Australia.

Significance: These cases highlight the importance of monitoring choroidal nevi with benign imaging characteristics and the potential to quantify horizontal growth using optical coherence tomography (OCT), in the absence of color fundus photography.

Purpose: This study aimed to present reports of two patients with pigmented choroidal tumors with low malignant potential based on their multimodal imaging features at the time of referral, but access to prior OCT imaging confirmed horizontal growth consistent with melanoma.Case ReportsTwo patients with pigmented, dome shaped, subfoveal tumors were referred. Read More

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Ocular malignancies treated with iodine-125 low dose rate (LDR) brachytherapy at a single high-volume institution: A retrospective review.

Med Dosim 2022 May 26. Epub 2022 May 26.

Department of Radiation Oncology, Texas Oncology, Brownsville, TX, USA.

The aim of our study is to document our cases of choroidal melanoma treated with low dose rate (LDR) brachytherapy and to correlate the dosimetry and radiobiology with clinical effects and oncologic outcomes. Data from 157 patients treated from 2014 to 2018 with LDR brachytherapy were used for this investigation. Treatments used a collaborative ocular melanoma study eye plaque and Iodine-125 radioactive seeds. Read More

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Laser Treatment for Choroidal Melanoma: Current Concepts.

Surv Ophthalmol 2022 May 26. Epub 2022 May 26.

Department of Ocular Tumor, Orbital Disease and Ophthalmic Radiation Therapy, The New York Eye Cancer Center, 115 East 61st Street, New York City, New York, USA, 10065.

Laser treatment has offered a relatively nonsurgical alternative for eye, life, and vision-sparing treatment of malignant melanoma of the choroid. Historically, the most commonly used forms of lasers were xenon-arc, argon laser, krypton laser, and the more recent transpupillary thermotherapy (TTT) and photodynamic therapy (PDT). Melanomas selected for laser treatment tend to be smaller and visibly accessible, which means these tumors are usually located in the posterior choroid. Read More

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Simple Congenital Hamartoma of Retinal Pigment Epithelium.

J Coll Physicians Surg Pak 2022 Apr;32(4):S31-S33

Department of Ophthalmology, Rashid Latif Medical College, Lahore, Pakistan.

A 45-year female presented in the Outpatient Department of a tertiary care hospital of Lahore with dimness of vision in the right eye. Her history revealed that the patient had noticed decreased vision since her childhood. Fundus examination revealed a jet-black slightly raised lesion about the size of ¼-disc diameter, located in the centre of macula. Read More

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Survey of ophthalmic imaging use to assess risk of progression of choroidal nevus to melanoma.

Eye (Lond) 2022 May 23. Epub 2022 May 23.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

Background/objectives: The aim of this study was to ascertain the use of ocular imaging and the updated screening criteria in the evaluation of choroidal nevus across the United States.

Methods: Sixty ophthalmologists completed an anonymous 21-question survey addressing their use of the screening criteria for evaluating choroidal nevi, as well as their use of ultrasonography (US), optical coherence tomography (OCT), and autofluorescence (AF) in daily practice.

Results: The majority of respondents were from the Northeast (55%), worked in private practice (83%), and practiced general ophthalmology (42%). Read More

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Intravitreal brolucizumab as treatment of early onset radiation retinopathy secondary to plaque brachytherapy for choroidal melanoma.

Am J Ophthalmol Case Rep 2022 Sep 14;27:101581. Epub 2022 May 14.

Department of Ophthalmology, Stanford University School of Medicine, 2452, Watson Ct, Palo Alto, CA, United States.

Purpose: To describe the efficacy and safety of brolucizumab (Beovu®, Novartis Pharmaceuticals) in a case of cystoid macular edema associated with radiation retinopathy as a result of iodine-125 plaque brachytherapy (PBT) for choroidal melanoma, resistant to treatment with other anti-vascular endothelial growth factor (VEGF) agents.

Observations: A 67-year-old woman with choroidal melanoma in the right eye and best-corrected visual acuity (BCVA) of 20/20, underwent uncomplicated PBT. On post-operative month 7, the patient developed early onset radiation retinopathy. Read More

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September 2022

Acute angle-closure attack as primary manifestation of choroidal melanoma: A case report.

J Fr Ophtalmol 2022 May 11. Epub 2022 May 11.

Service d'ophtalmologie A, CHU d'Ibn-Sina, université Mohammed V, Souissi, hôpital des Spécialités, BP 6220, Rabat, Morocco.

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Metastatic lesion of choroidal melanoma located in the head of pancreas.

Rev Esp Enferm Dig 2022 May 12. Epub 2022 May 12.

UGC Aparato Digestivo, Hospital Universitario Reina Sofía, ESPAÑA.

Metastases in pancreas are uncommon, ranging from 2 to 5 % of pancreatic malignancies. Choroidal melanoma is rare, and less than 1% spread to the pancreas. It can cause obstructive jaundice if it affects the pancreatic head region. Read More

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Scleral communication between Glaucoma drainage device capsule and the suprachoroidal space simulating amelanotic choroidal melanoma.

Arq Bras Oftalmol 2022 May 9. Epub 2022 May 9.

Ophthal Hospital Especializado Ltda, São Paulo, SP, Brasil.

This is a case report involving a 56-year-old male patient with a history of pars plana vitrectomy due to a rhegmatogenous retinal detachment in the right eye that resulted in the implantation of a drainage device after the patient developed secondary glaucoma. Two years after the device's implantation, the patient was referred to our care as his visual acuity had decreased to 20/200 (1.00 LogMAR). Read More

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Partial spontaneous regression of choroidal melanoma: A case image with histopathology and gene expression profiling.

Am J Ophthalmol Case Rep 2022 Jun 12;26:101517. Epub 2022 Apr 12.

The University of Texas at Austin Dell Medical School, Austin, TX, USA.

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Improving organs-at-risk sparing for choroidal melanoma patients: A CT-based two-beam strategy in ocular proton therapy with a dedicated eyeline.

Radiother Oncol 2022 06 27;171:173-181. Epub 2022 Apr 27.

Erasmus Medical Center, Cancer Institute, Department of Radiotherapy, Rotterdam, The Netherlands; Holland Proton Therapy Center, Delft, The Netherlands.

Purpose: To investigate the potential clinical benefit of a two-beam arrangement technique using three-dimensional (3D) imaging of uveal melanoma (UM) patients treated with proton therapy and a dedicated eyeline.

Material/methods: Retrospective CT-based treatment plans of 39 UM patients performed using a single beam (SB) were compared to plans with two beams (TB) optimized for better trade-offs in organs-at-risk sparing. The RBE-weighted prescribed dose was 60 Gy (D = 60 Gy) in four fractions, assuming an RBE of 1. Read More

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Surgical Approach in Intraocular Tumors

Turk J Ophthalmol 2022 04;52(2):125-138

Ankara University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey

Surgery in intraocular tumors is done for excision/biopsy and the management of complications secondary to the treatment of these tumors. Excision/biopsy of intraocular tumors can be done via fine-needle aspiration biopsy (FNAB), transretinal biopsy (TRB), partial lamellar sclerouvectomy (PLSU), and endoresection. FNAB, TRB, and PLSU can be used in tumors that cannot be diagnosed by clinical examination and other ancillary testing methods. Read More

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"De novo" Appearance of a Choroidal Melanoma During 5 Years' Follow-up for CHRPE.

Klin Monbl Augenheilkd 2022 04 26;239(4):590-592. Epub 2022 Apr 26.

Ophthalmology, Hôpital ophtalmique Jules-Gonin, University of Lausanne, Lausanne, Switzerland.

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Unusual initial manifestation of choroidal melanoma in a 46-year-old adult with rapid growth over 9 months.

Am J Ophthalmol Case Rep 2022 Jun 12;26:101518. Epub 2022 Apr 12.

Department of Ophthalmology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Purpose: To report a case with unusual initial manifestation of uveal melanoma in a 46-year-old adult.

Observations: A 46-year-old man demonstrated a mid-peripheral temporal partially hyperpigmented lesion in his left eye. Initial clinical appearance as well as multimodal imaging approaches were similar to a chorioretinitic disease. Read More

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Population-based incidence of intraocular tumours in Olmsted County, Minnesota.

Br J Ophthalmol 2022 Apr 21. Epub 2022 Apr 21.

Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA

Background/aims: To determine population-based incidence of intraocular tumours in Olmsted County, Minnesota.

Methods: Record review of the Rochester Epidemiology Project medical record linkage system from 1 January 2006 to 31 December 2015 for patient demographics, tumour type by clinical diagnosis and presence or absence of confirmation by histopathology. The incidence rate of any intraocular tumour and of each tumour type was calculated per million person-years. Read More

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The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature.

BMC Cancer 2022 Apr 13;22(1):398. Epub 2022 Apr 13.

Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, 171 64, Stockholm, Sweden.

Background: Uveal melanoma is a rare form of cancer with high mortality. The incidence of metastases is attributed to early seeding of micrometastases from the eye to distant organs, primarily the liver. Once these seeded clusters of dormant tumor cells grow into larger radiologically detectable macrometastases, median patient survival is about 1 year. Read More

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Fundus Autofluorescence Imaging in Patients with Choroidal Melanoma.

Cancers (Basel) 2022 Apr 2;14(7). Epub 2022 Apr 2.

Department of Ophthalmology, DRK Kliniken Berlin Westend, 14050 Berlin, Germany.

Choroidal melanocytic lesions require reliable and precise clinical examination and diagnosis to differentiate benign choroidal nevi from choroidal melanoma, as the latter may become life-threatening through metastatic disease. To come to an accurate diagnosis, as well as for monitoring, and to assess the efficacy of therapy, various imaging modalities may be used, one of which is non-invasive fundus autofluorescence (FAF) imaging using novel high-resolution digital imaging technology. FAF imaging is based on the visualization of intrinsic fluorophores in the ocular fundus. Read More

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Robotic CyberKnife radiosurgery for small choroidal melanomas.

Melanoma Res 2022 06 8;32(3):192-199. Epub 2022 Apr 8.

Department of Ophthalmology, University Hospital, LMU Munich.

Plaque brachytherapy is the most common procedure for the treatment of small choroidal melanoma, especially in posteriorly located tumors. However, there is only little information on outcome after treatment with stereotactic radiosurgery, for example, CyberKnife radiosurgery. We reviewed patients with choroidal melanoma (maximum tumor height 4 mm) treated with CyberKnife radiosurgery. Read More

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Longitudinal optical coherence tomography angiography (OCT-A) in a patient with radiation retinopathy following plaque brachytherapy for uveal melanoma.

Am J Ophthalmol Case Rep 2022 Jun 25;26:101508. Epub 2022 Mar 25.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA, USA.

Purpose: Patients with choroidal melanoma treated with brachytherapy lose vision over time due to radiation retinopathy and optic neuropathy. Newer imaging modalities such as optical coherence tomography angiography (OCT-A) may provide further insight into the ultrastructural vascular changes that occur over time. We studied the progressive OCT-A derived reduction in capillary density that occurred in the macula and juxtapapillary region of a patient treated with plaque brachytherapy for posterior uveal melanoma. Read More

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Long term outcome of adjuvant photodynamic therapy after cyberknife radiotherapy for choroidal melanoma.

Photodiagnosis Photodyn Ther 2022 Jun 31;38:102840. Epub 2022 Mar 31.

Retina Service, Department of Ophthalmology, Sakarya University, Sakarya, Turkey.

Purpose: To report the outcome of photodynamic therapy (PDT) for choroidal melanoma as adjuvant treatment with CyberKnife radiotherapy.

Design: Retrospective interventional case series.

Methods: Standard-fluence PDT using verteporfin. Read More

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Choroidal melanoma with synchronous Fuchs' adenoma and novel ATRX mutation.

Int J Retina Vitreous 2022 Apr 1;8(1):24. Epub 2022 Apr 1.

Queensland Ocular Oncology Service, Terrace Eye Centre, 2/87 Wickham Terrace, Spring Hill, QLD, 4011, Australia.

Background: To report a case of Fuchs' adenoma occurring in an eye with a large choroidal melanoma. We have reviewed the literature to describe the clinical presentation, ultrasound characteristics and pathological features of these entities.

Case Presentation: A 69-year-old Caucasian man presented with vision loss from a large choroidal melanoma. Read More

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Small Choroidal Melanoma: Outcomes After Surveillance Versus Immediate Treatment.

Am J Ophthalmol 2022 Mar 28;241:47-56. Epub 2022 Mar 28.

Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic (E.C.Z.), Cleveland, Ohio, USA.

Purpose: To quantify potential loss (loss of vision) and gain (freedom from metastasis) in patients with small choroidal melanoma treated after a period of surveillance to document growth.

Methods: A total of 167 patients with small choroidal melanoma (size: 5.0-16. Read More

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Improved Prognostic Precision in Uveal Melanoma through a Combined Score of Clinical Stage and Molecular Prognostication.

Ocul Oncol Pathol 2022 Feb 1;8(1):35-41. Epub 2021 Nov 1.

Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, Michigan, USA.

Introduction: Prognosis of uveal melanoma (UM) is assessed using clinical staging or molecular testing. Two modalities often used for prognostication are the American Joint Committee on Cancer (AJCC) staging and a tumor gene expression profile (GEP), the outcomes of which are often discordant. This article discusses a total risk score created to combine the discordant information from both sources. Read More

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February 2022

A Prediction Model to Discriminate Small Choroidal Melanoma from Choroidal Nevus.

Ocul Oncol Pathol 2022 Feb 22;8(1):71-78. Epub 2021 Dec 22.

Cole Eye Institute, Ophthalmic Oncology, Cleveland Clinic, Cleveland, Ohio, USA.

Objective: This study aimed to develop a validated machine learning model to diagnose small choroidal melanoma.

Design: This is a cohort study.

Subjects Participants And/or Controls: The training data included 123 patients diagnosed as small choroidal melanocytic tumor (5. Read More

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February 2022

The Prognostic Relevance of PMCA4 Expression in Melanoma: Gender Specificity and Implications for Immune Checkpoint Inhibition.

Int J Mol Sci 2022 Mar 19;23(6). Epub 2022 Mar 19.

Department of Thoracic Surgery, University Medicine Essen-Ruhrlandklinik, 45239 Essen, Germany.

PMCA4 is a critical regulator of Ca homeostasis in mammalian cells. While its biological and prognostic relevance in several cancer types has already been demonstrated, only preclinical investigations suggested a metastasis suppressor function in melanoma. Therefore, we studied the expression pattern of PMCA4 in human skin, nevus, as well as in primary and metastatic melanoma using immunohistochemistry. Read More

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Extrascleral Extension from Choroidal Melanoma Diagnosed on Doppler Ultrasound.

Ophthalmology 2022 04;129(4):405

Ocular Oncology Service, Moorfields Eye Hospital, London, United Kingdom; Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, United Kingdom.

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Metastatic tumours to the eye. Review of metastasis to the iris, ciliary body, choroid, retina, optic disc, vitreous, and/or lens capsule.

Eye (Lond) 2022 Mar 19. Epub 2022 Mar 19.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

Metastasis to the eye can involve the choroid (90%), ciliary body (2%), iris (8%), and retina, optic disc, vitreous, and/or lens capsule (<1-4%). The mean number of uveal metastasis per eye (1.7), mean tumour base (11. Read More

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The long-term prognosis of patients with untreated primary uveal melanoma: A systematic review and meta-analysis.

Crit Rev Oncol Hematol 2022 Apr 15;172:103652. Epub 2022 Mar 15.

Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Tomtebodavägen 18A, plan 5, 171 77 Stockholm, Sweden; Department of Pathology, Västmanland Hospital Västerås, Västerås, Sweden.

Purpose: To examine patient survival in untreated primary uveal melanoma.

Methods: Systematic review and meta-analysis.

Results: Seven studies with a total of 19 patients were included. Read More

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