2,936 results match your criteria Melanoma Choroidal


[UNUSUAL VITREOUS DETACHMENT].

Harefuah 2019 Feb;158(2):109-111

Ocular Oncology Service - The Goldschleger Eye Institute, Sheba Medical Center, Tel-Aviv University, Israel.

Introduction: A 49 years old patient with a history of brachytherapy for choroidal melanoma was referred to the ocular emergency room for suspected recurrence due to pigment in the vitreous cavity. On examination, pigmented vitreous secondary to posterior vitreous detachment with traction from the atrophic tumor was observed with no evidence of recurrence. Read More

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February 2019

THE SMALL FATAL CHOROIDAL MELANOMA STUDY A Survey by the European Ophthalmic Oncology Group.

Am J Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Ocular Oncology Service, Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Purpose: To determine the size at which choroidal melanomas can metastasize and to report the characteristics of small fatal choroidal melanomas (SFCM).

Design: Retrospective case series.

Methods: Ten ocular oncology services submitted 45 patients with a choroidal melanoma 3 mm or less in thickness and 9 mm or less in largest basal diameter (LBD), when treated, who developed metastases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394193006
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http://dx.doi.org/10.1016/j.ajo.2019.01.031DOI Listing
February 2019
1 Read

Endogenous fluorescence can differentiate the keratoconic cornea.

Exp Eye Res 2019 Feb 5;181:178-184. Epub 2019 Feb 5.

Department of Biophysics and Molecular Physics, A. Chelkowski Institute of Physics, Silesian Center for Education and Interdisciplinary Research, University of Silesia, 41-500 Chorzów, 75 Pułku Piechoty 1A, Poland.

The purpose of the study was to investigate the endogenous fluorescence of the keratoconic cornea in order to analyze changes in the spectra due to the keratoconic stroma abnormalities. Twenty-two corneal buttons obtained from patients with keratoconus (KC, N = 22) at the time of penetrating keratoplasty were used. As a reference, twelve normal corneas (N = 12): ten from the Eye Bank and two from enucleated eyes due to choroidal melanoma were used. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144835183076
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http://dx.doi.org/10.1016/j.exer.2019.02.002DOI Listing
February 2019
2 Reads

Statins in Ophthalmology.

Surv Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia.

3-Hydroxy-3-methyl-gutaryl coenzyme A (HMG-CoA) reductase inhibitors or 'statins' are a class of lipid lowering drugs with anti-inflammatory, immunomodulatory, and vascular effects. Statins are increasingly being used in the treatment of a variety of medical conditions. We examine the actions of statins on the eye and its associated ophthalmic disorders. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.01.013DOI Listing
January 2019
7 Reads

The Amazon Ocular Oncology Center: The first three years.

Arq Bras Oftalmol 2019 Mar-Apr;82(2):107-110. Epub 2019 Jan 24.

Centro de Oncologia Ocular, Departamento de Ofalmologia e Ciências Visuais, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Purpose: To evaluate the first three years of The Amazon Ocular Oncology Center, the first ocular cancer center in the North of Brazil.

Methods: Here, we report patient information including patients' age, gender, diagnosis, treatment, and city of origin.

Results: Two hundred and twenty-one patients were included on this study: 160 (72%) patients came from the city of Manaus, 52 (24%) from other cities in Amazonas, and 9 (4%) from other states. Read More

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http://dx.doi.org/10.5935/0004-2749.20190024DOI Listing
January 2019
1 Read

Trends in Radiation Practices for Female Ocular Oncologists in North America: A Collaborative Study of the International Society of Ocular Oncology.

Ocul Oncol Pathol 2019 Jan 12;5(1):54-59. Epub 2018 Jun 12.

USC Roski Eye Institute, University of Southern California, Los Angeles, California, USA.

Background: The aim of this study was to determine the known radiation exposure, attitudes, and consequent risk modifications among female ocular oncologists in North America who routinely administer radioactive plaque brachytherapy treatment and are members of the International Society of Ocular Oncology.

Methods: Nineteen female ocular oncologists completed an anonymous 17-question radiation exposure survey.

Results: Eleven of the participants chose to routinely wear lead protection during surgery; 8 did not. Read More

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https://www.karger.com/Article/FullText/489219
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http://dx.doi.org/10.1159/000489219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341326PMC
January 2019
4 Reads

Outcomes of Glaucoma Drainage Device Surgery in Eyes with Treated Uveal Melanoma.

Ocul Oncol Pathol 2019 Jan 2;5(1):20-27. Epub 2018 May 2.

Stein Eye and Doheny Eye Institutes, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Aim: We report patient safety and intraocular pressure (IOP) control after placement of a glaucoma drainage device (GDD) in eyes with a history of treated malignant uveal melanoma.

Methods: A retrospective review of the records of patients with uveal melanoma was performed. Outcomes were local tumor recurrence, rate of metastases, and to-nometric success, based on survival curves, defined as IOP < 21 mm Hg. Read More

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https://www.karger.com/Article/FullText/488056
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http://dx.doi.org/10.1159/000488056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341335PMC
January 2019
4 Reads

Multifocal Primary Uveal Melanoma: Clinical and Molecular Characteristics.

Ocul Oncol Pathol 2019 Jan 27;5(1):8-12. Epub 2018 Apr 27.

Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

We report two patients who developed a second distinct choroidal melanoma in the same eye following successful regression of their first choroidal melanoma after iodine-125 plaque brachytherapy. Neither patient demonstrated ocular melanocytosis, local tumor recurrence, or vitreous seeding. One patient had the second tumor arising from a previously documented choroidal nevus, and after undergoing enucleation, there was no detectable connection between the tumors on histopathologic examination. Read More

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https://www.karger.com/Article/FullText/487891
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http://dx.doi.org/10.1159/000487891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341333PMC
January 2019
4 Reads

Outcomes of I-125 brachytherapy for uveal melanomas depending on irradiation dose applied to the tumor apex - a single institution study.

J Contemp Brachytherapy 2018 Dec 28;10(6):532-541. Epub 2018 Dec 28.

Department of Ophthalmology and Ocular Oncology of University Hospital, Cracow.

Purpose: The aim of the study was an evaluation of I-125 brachytherapy patients with uveal melanoma with special consideration for the relationship of the treatment results and the irradiation dose applied to the tumor apex.

Material And Methods: Medical records of 344 adults with uveal melanoma treated with I-125 brachytherapy in the Department of Ophthalmology and Ocular Oncology of the Jagiellonian University, Medical College in Cracow, Poland were retrospectively analyzed. The study was conducted between 2003 and 2012, and the study group was divided into two subgroups depending on the irradiation dose applied to the top of the tumor: 80 Gy to 100 Gy ( = 177) and 100 Gy to 120 Gy ( = 167). Read More

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http://dx.doi.org/10.5114/jcb.2018.79886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335559PMC
December 2018

Intraocular schwannoma: A case series of 3 patients.

Oncol Lett 2019 Jan 16;17(1):1274-1278. Epub 2018 Nov 16.

Department of Ophthalmology, Peking University People's Hospital, Beijing 100044, P.R. China.

Schwannoma is a proliferation of neoplastic Schwann cells. Schwannomas comprise 8-10% of all primary intracranial tumors. Primary intraorbital schwannoma arising from the ciliary nerves in the uvea, which accounts for 1-2% of all intracranial tumors, is a rare intraocular neoplasm. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9718
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http://dx.doi.org/10.3892/ol.2018.9718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313066PMC
January 2019
3 Reads

Late Apical Recurrence of Choroidal Melanoma 10 Years after Successful Treatment with Brachytherapy.

Ocul Oncol Pathol 2018 Jun 22;4(4):225-229. Epub 2017 Dec 22.

University of Southern California Roski Eye Institute, Los Angeles, CA, USA.

Purpose: To describe late apical relapse of a choroidal melanoma at the site of fine needle aspiration biopsy 10 years following successful treatment with I brachytherapy.

Methods: Retrospective case report of a 78-year-old male presenting 10 years following successful I brachytherapy for a choroidal melanoma with a medium-sized nodular amelanotic tumor recurrence at the site of the prior tumor biopsy.

Results: Fundus photography and B-scan ultrasound documented the findings at presentation at our institution. Read More

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https://www.karger.com/Article/FullText/485131
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http://dx.doi.org/10.1159/000485131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322081PMC
June 2018
8 Reads

Rare Occurrence of an Intraocular Choroidal Solitary Fibrous Tumor/Hemangiopericytoma.

Ocul Oncol Pathol 2018 Jun 16;4(4):213-219. Epub 2017 Dec 16.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Purpose: Tumors previously diagnosed as solitary fibrous tumors (SFT) and hemangiopericytomas (HPC) are characterized by the fusion gene, leading to nuclear STAT6 expression, and are now considered part of one SFT/HPC tumor entity by the 2016 World Health Organization Classification of Tumors of the Central Nervous System. We present the first primary choroidal SFT/HPC with the diagnosis confirmed by STAT6 expression.

Procedures: A 51-year-old man underwent enucleation for a choroidal mass, which revealed a spindle cell neoplasm involving the optic nerve, without extrascleral extension. Read More

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http://dx.doi.org/10.1159/000481947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322087PMC

CHOROIDAL MELANOMA DURING PREGNANCY: A CASE REPORT AND REVIEW OF THE LITERATURE.

Retin Cases Brief Rep 2019 Jan 11. Epub 2019 Jan 11.

Duke Eye Center, Duke University School of Medicine, Durham, North Carolina.

Purpose: To report a case of a woman diagnosed with choroidal melanoma during pregnancy, as well as review similar cases published in the literature. The prevalence, risk factors, treatment, prognosis, and outcomes of choroidal melanoma in pregnancy are addressed.

Methods: An extensive search of the literature was conducted by accessing PubMed, MEDLINE, and Scopus databases in January 2018 to identify cases of choroidal or uveal melanoma diagnosed during pregnancy. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000851DOI Listing
January 2019
3 Reads

Single-Stage Orbital Socket Reconstruction Using the Oversized Dermis Fat Graft and the 22 mm Silicone Orbital Implant after an Extended Enucleation.

Case Rep Ophthalmol Med 2018 4;2018:8954193. Epub 2018 Dec 4.

University Eye Clinic, Faculty of Dental Medicine and Health Care Osijek, Faculty of Medicine Osijek, University Josip Juraj Strossmayer in Osijek, University Hospital "Sveti Duh", Zagreb, Croatia.

We would like to present a surgical technique of orbital socket reconstruction using oversized dermis fat graft and 22 mm silicone orbital implant in a single-stage after extended enucleation in two patients with massive local recurrence of anteriorly located choroidal melanoma previously treated with endoresection. Orbital tissues en bloc were removed leaving conjunctival lining only at the fornices. Simultaneously, the 22 mm silicone sphere was implanted deeply into the orbit and covered with the oversized dermis fat graft of 30 mm in height and 35 mm in length with 20 mm of the fat thickness. Read More

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https://www.hindawi.com/journals/criopm/2018/8954193/
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http://dx.doi.org/10.1155/2018/8954193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304640PMC
December 2018
4 Reads

CHOROIDAL NEVUS IMAGING FEATURES IN 3,806 CASES AND RISK FACTORS FOR TRANSFORMATION INTO MELANOMA IN 2,355 CASES: The 2020 Taylor R. Smith and Victor T. Curtin Lecture.

Retina 2018 Dec 31. Epub 2018 Dec 31.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose: To use multimodal imaging for identification of risk factors for choroidal nevus transformation into melanoma.

Methods: Retrospective chart review of 3806 consecutive choroidal nevi with imaging and 2355 choroidal nevi with additional follow up to identify factors predictive of transformation of choroidal nevus into melanoma.

Results: The median patient age was 62. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002440DOI Listing
December 2018

Rhegmatogenous retinal detachment in a patient with choroidal melanoma simulating choroidal detachment: a case report.

J Med Case Rep 2018 Dec 25;12(1):389. Epub 2018 Dec 25.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.

Background: Ophthalmologists and retina specialists may consider choroidal detachment if patients with rhegmatogenous retinal detachment present with choroidal elevation. That misdiagnosis may lead to inappropriate treatments, development of tumor cell dissemination, and eventual promotion of patient death. We report a case of a patient with rhegmatogenous retinal detachment associated with choroidal melanoma simulating choroidal detachment according to fundus findings. Read More

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http://dx.doi.org/10.1186/s13256-018-1921-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305567PMC
December 2018
1 Read

The Use of Intravitreal Anti-VEGF and Triamcinolone in the Treatment of Radiation Papillopathy.

Ocul Oncol Pathol 2018 Nov 8;4(6):395-400. Epub 2018 Jun 8.

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alberta, Canada.

Background/aims: To evaluate a treatment regimen for radiation papillopathy.

Methods: This is a prospective noncomparative interventional case series of patients who developed radiation papillopathy after plaque brachytherapy for uveal melanoma. Treatment consisted of intravitreal bevacizumab (IVB) (1. Read More

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http://dx.doi.org/10.1159/000487543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288662PMC
November 2018

Surface-Coil MRI for Small Peripheral Choroidal Melanoma: Imaging in a Rabbit Eye Model.

Ocul Oncol Pathol 2018 Nov 13;4(6):364-369. Epub 2018 Jun 13.

Department of Ophthalmology, University Hospital of Heraklion, Heraklion, Greece.

Introduction: Imaging of small peripheral choroidal melanomas remains challenging in clinical and experimental settings, requiring wide-field ophthalmoscopy modalities. In this study, we applied surface-coil MRI to assess imaging feasibility for small peripherally located choroidal melanoma in a rabbit eye model.

Methods: A female albino rabbit with a body weight of 2. Read More

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https://www.karger.com/Article/FullText/486789
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http://dx.doi.org/10.1159/000486789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288665PMC
November 2018
1 Read

Two Uveal Melanomas in One Eye: A Choroidal Nevus Giving Rise to a Melanoma in an Eye with a Separate Large Choroidal Melanoma.

Ocul Oncol Pathol 2018 Nov 2;4(6):355-358. Epub 2018 Mar 2.

Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Multifocal uveal melanomas are extremely rare. In this case report, we describe a patient with 2 independent uveal melanomas in the same eye. A 52-year-old woman presented with a large choroidal melanoma and a smaller ciliary body mass, clinically thought to be a nevus, in her left eye. Read More

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http://dx.doi.org/10.1159/000486682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288664PMC
November 2018

Kenalog modified by ionizing radiation induces intrinsic apoptosis mediated by elevated levels of reactive oxygen species in melanoma cancer.

Oncol Rep 2019 Mar 19;41(3):1837-1850. Epub 2018 Dec 19.

Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup‑si, Jeollabuk‑do 580‑185, Republic of Korea.

Kenalog is a synthetic glucocorticoid drug used to treat various cancers including ocular and choroidal melanoma. However, the drug achieves rarely sustainable results for patients. To overcome this difficulty, the structure of Kenalog was altered by ionizing radiation (IR) to develop a more effective anticancer agent for treatment of various skin cancers. Read More

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http://dx.doi.org/10.3892/or.2018.6940DOI Listing
March 2019
1 Read

Choroidal melanoma masquerading as orbital cellulitis.

BMJ Case Rep 2018 Dec 9;11(1). Epub 2018 Dec 9.

Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Orbital cellulitis is the most common subset of orbital inflammatory disease. We describe a patient with necrotic choroidal melanoma who presented with orbital cellulitis. MRI revealed a mass lesion suggesting intraocular melanoma with no extrascleral extension. Read More

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http://dx.doi.org/10.1136/bcr-2018-227486DOI Listing
December 2018

Glaucoma secondary to intraocular tumors: mechanisms and management.

Curr Opin Ophthalmol 2019 Mar;30(2):71-81

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose Of Review: Glaucoma secondary to intraocular tumors is important to consider in eyes with a known tumor and those with unilateral or refractory glaucoma. The purpose of this review is to discuss the mechanisms and management of intraocular tumors with related secondary glaucoma.

Recent Findings: Several intraocular tumors can lead to glaucoma, including iris melanoma, iris metastasis, iris lymphoma, trabecular meshwork melanoma, choroidal melanoma, choroidal metastasis, retinoblastoma, and medulloepithelioma. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000550DOI Listing
March 2019
7 Reads

Ocular ultrasound versus MRI in the detection of extrascleral extension in a patient with choroidal melanoma.

BMC Ophthalmol 2018 Dec 12;18(1):320. Epub 2018 Dec 12.

Department of Ophthalmology, University of Utah, Salt Lake City, UT, USA.

Background: To describe the superiority of ocular ultrasound in the diagnostic management of extrascleral extension in choroidal melanoma.

Case Presentation: We present a case of a 94-year-old male with choroidal melanoma of the right eye imaged with MRI and ocular ultrasound to aid in the detection of extrascleral extension.

Conclusions: With advancement in technology and new imaging modalities emerging, it can become difficult to determine the best diagnostic approach for patients. Read More

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http://dx.doi.org/10.1186/s12886-018-0990-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291956PMC
December 2018
2 Reads

Combination of multimodal imaging features predictive of choroidal nevus transformation into melanoma.

Br J Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Aim: To characterise combinations of multimodal imaging risk factors and predictive value for choroidal nevus transformation into melanoma.

Methods: This is a retrospective review of multimodal imaging features for 3806 choroidal nevi from 1 January 2007 through 1 January 2017. Kaplan-Meier estimates and Cox regression analyses were used to calculate 5-year percentages of growth to melanoma and HR. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3129
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http://dx.doi.org/10.1136/bjophthalmol-2018-312967DOI Listing
December 2018
3 Reads

Scleritis-associated vortex vein varix masquerading as choroidal melanoma.

Can J Ophthalmol 2018 Dec 2;53(6):e260-e262. Epub 2018 Apr 2.

Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.

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http://dx.doi.org/10.1016/j.jcjo.2018.02.002DOI Listing
December 2018
1 Read

[Unilateral multifocal uveal melanoma (a clinical and genetic study)].

Vestn Oftalmol 2018 ;134(5):78-85

Institute of General Pathology and Pathophysiology, 8 Baltiiskaya St., Moscow, Russian Federation, 125315.

The study presents clinical and genetic analysis of a case of unilateral multifocal uveal choroidal melanoma in a patient of 67 years. Results of ophthalmoscopy, echography, fluorescent angiography, optical coherence tomography are described. Molecular genetic testing of peripheral blood samples was performed, including detection of the occurrences of CC genotype in C3435T polymorphism of the gene ABCB1/MDR1 associated with unfavorable vital prognosis. Read More

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http://dx.doi.org/10.17116/oftalma201813405178DOI Listing
January 2018
11 Reads

[Morphogenesis of choroidal melanomas in OCT imaging].

Vestn Oftalmol 2018 ;134(5. Vyp. 2):186-194

S.P. Botkin Moscow City Clinical Hospital, Branch No. 1, Ophtalmooncology department, 7 Mamonovskiy Lane, Moscow, Russian Federation, 123001.

When planning conservation therapy for choroidal melanoma (CM), evaluation of its size and stage is done using various methods of visualization, among which is optical coherence tomography (OCT). A recently introduced modification of OCT - Enhanced Depth Imaging (EDI) allows observation of deep choroid and sclera.

Purpose: To specify clinicomorphologic correlations between OCT signs related to CM and its pathomorphological state as described in literature. Read More

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http://dx.doi.org/10.17116/oftalma2018134051186DOI Listing
January 2018
9 Reads

[Ultrasound diagnosis and differential diagnosis of medium and small choroidal melanomas].

Zhonghua Yan Ke Za Zhi 2018 Nov;54(11):843-848

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab., Beijing Key Lab. of Intraocular Tumor Diagnosis and Treatment, Beijing 100730, China.

To analyze the ultrasound diagnosis and differential diagnosis of medium and small choroidal melanomas. It was a retrospective case series study. Thirty-six cases (36 eyes) with medium or small choroidal melanoma were collected between January 2016 and January 2017 in Beijing Tongren Hospital, including 16 males and 20 females aged (50±12) years old. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2018.11.009DOI Listing
November 2018
9 Reads

Clinical Features, Metastasis, and Survival in Patients Younger Than 21 Years With Posterior Uveal Melanoma.

JAMA Ophthalmol 2019 Jan;137(1):75-81

Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, Ohio.

Importance: Given the rarity of posterior uveal melanoma in patients younger than 21 years, reporting clinical experience in this area has relevance.

Objective: To describe the baseline clinical features, treatment, and clinical course of a group of patients younger than 21 years who have primary posterior uveal melanoma.

Design, Setting, And Participants: This retrospective descriptive case series of patients younger than 21 years who have a primary choroidal or ciliochoroidal melanoma was conducted at a single-center subspecialty referral practice. Read More

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https://jamanetwork.com/journals/jamaophthalmology/fullartic
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https://jamanetwork.com/collections/5798/intraocular-tumors
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https://jamanetwork.com/journals/jamaophthalmology/fullartic
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http://dx.doi.org/10.1001/jamaophthalmol.2018.5132DOI Listing
January 2019
9 Reads

Subretinal Fluid Optical Density and Spectral-Domain Optical Coherence Tomography Characteristics for the Diagnosis of Circumscribed Choroidal Hemangioma.

Ophthalmologica 2018 Nov 5:1-7. Epub 2018 Nov 5.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: To investigate spectral domain-optical coherence tomography (SD-OCT) features of untreated circumscribed choroidal hemangioma (CCH), and the optical density (OD) of the associated subretinal fluid (SRF).

Procedures: This international retrospective multicenter study conducted at 5 tertiary retina referral centers included 34 patients with symptomatic CCH imaged on SD-OCT. CCH surface, size, and overlying retinal changes and OD ratio (ODR) were evaluated. Read More

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https://www.karger.com/Article/FullText/492948
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http://dx.doi.org/10.1159/000492948DOI Listing
November 2018
8 Reads

Regression rate of choroidal melanoma following iodine-125 brachytherapy is not associated with metastatic spread.

Melanoma Res 2018 Oct 31. Epub 2018 Oct 31.

Centre universitaire d'ophtalmologie (CUO).

Nearly half of choroidal melanomas progress to the metastatic stage at 15 years. The purpose of our study was to evaluate the prognostic value of tumour-height regression rate in medium-sized choroidal melanomas treated with iodine-125 brachytherapy. A retrospective cohort study was performed on 128 patients with medium-sized choroidal melanoma who were treated with iodine-125 brachytherapy. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000540DOI Listing
October 2018

Sympathetic ophthalmia associated with untreated choroidal melanoma.

Can J Ophthalmol 2018 Oct 3;53(5):e173-e176. Epub 2018 Feb 3.

John Hunter Hospital, Newcastle, Australia.

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http://dx.doi.org/10.1016/j.jcjo.2017.11.013DOI Listing
October 2018

Uveal melanoma survival rates after single dose stereotactic radiosurgery.

Neoplasma 2018 Nov 4;65(6):965-971. Epub 2018 Sep 4.

Department of Ophthalmology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

This paper presents the long-term results of single dose stereotactic radiosurgery for intraocular uveal malignant melanoma, and summarizes the results of the retrospective study in 170 Slovak patients. A group of uveal melanoma patients (149 choroidal melanoma, 21 ciliary body melanoma) from 20 to 92 years of age with 59 year median were treated in 2001-2016. There were 81males (47. Read More

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http://dx.doi.org/10.4149/neo_2018_171209N808DOI Listing
November 2018
1 Read

Metastatic choroidal melanoma to the contralateral eye: a rare case.

Arq Bras Oftalmol 2018 Nov./Dec.;81(6):517-519. Epub 2018 Oct 11.

Intervention Radiology Service, Radiology Department, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Uveal melanoma is the most common adult primary intraocular cancer. Although liver metastasis is common to the natural history of the disease, metastasis to the fellow eye is extremely rare. Here we report the case of a 59-year-old man with choroidal melanoma in his right eye who underwent enucleation at a different center. Read More

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http://dx.doi.org/10.5935/0004-2749.20180099DOI Listing
October 2018
2 Reads

20-year assessment of metastatic latency and subsequent time to death after proton therapy for uveal melanomas.

Melanoma Res 2018 Oct 12. Epub 2018 Oct 12.

Department of Ophthalmology, Croix-Rousse University Hospital.

The aim of this study was to evaluate metastatic latency and survival after the occurrence of metastases in patients with choroidal/ciliary body melanoma treated with proton therapy. This was a retrospective cohort study. All consecutive patients with choroidal/ciliary body melanoma treated with proton therapy between 1991 and 2010 were included. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000519DOI Listing
October 2018

Conjunctival Dehiscence and Scleral Necrosis following Iodine-125 Plaque Brachytherapy for Uveal Melanoma: A Report of 3 Cases.

Ocul Oncol Pathol 2018 Sep 13;4(5):291-296. Epub 2018 Feb 13.

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA.

Background/aims: Plaque brachytherapy is currently the most common treatment for uveal melanoma and has many known potential complications. Here we present 3 cases of early conjunctival and scleral necrosis following iodine-125 plaque.

Methods: This study was conducted as a retrospective case series. Read More

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https://www.karger.com/Article/FullText/481858
Publisher Site
http://dx.doi.org/10.1159/000481858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167656PMC
September 2018
6 Reads

Orbital Cellulitis and Secondary Angle Closure: A Rare Presentation of Choroidal Melanoma.

Ocul Oncol Pathol 2018 Sep 26;4(2):130-133. Epub 2017 Sep 26.

Save Sight Institute, Sydney, NSW, Australia.

We describe a case of choroidal melanoma initially presenting with orbital cellulitis, fulminant conjunctival swelling, and secondary angle closure. Despite treatment with intravenous antibiotics, the patient's condition did not improve. With further investigations including ultrasound scan and magnetic resonance imaging, a high-density lesion was found within the globe. Read More

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https://www.karger.com/Article/FullText/477546
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http://dx.doi.org/10.1159/000477546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167683PMC
September 2018
11 Reads

Extrascleral Tumor Extension Associated with Localized Scleral Melt following Plaque Brachytherapy for Uveal Melanoma: Clinical and Histologic Findings.

Ocul Oncol Pathol 2018 Sep 23;4(2):93-99. Epub 2017 Aug 23.

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA.

Background/aims: Our study aims to better characterize the clinical and histopathologic features of eyes with extrascleral uveal melanoma associated with scleral melt following brachytherapy.

Methods: A retrospective review was performed on patients who had undergone I (iodine-125) brachytherapy for uveal melanoma at our institution between 1992 and 2015. Patients with postradiation scleral necrosis who required enucleation were identified, and an analysis including a review of histopathology results was performed on those cases. Read More

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http://dx.doi.org/10.1159/000477302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167664PMC
September 2018

Two-Toned Lipofuscin in the Same Choroidal Melanoma: Orange versus Gray.

Ophthalmology 2018 Nov;125(11):1792

Department of Ophthalmology, University of California San Francisco, San Francisco, California; Department of Ophthalmology, The Permanente Medical Group, San Francisco, California.

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http://dx.doi.org/10.1016/j.ophtha.2018.07.029DOI Listing
November 2018

99mTc-3PRGD2 single-photon emission computed tomography/computed tomography for the diagnosis of choroidal melanoma: A preliminary STROBE-compliant observational study.

Medicine (Baltimore) 2018 Oct;97(40):e12441

Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing.

Recent successes in monitoring and diagnosing a variety of tumors using Tc-PEG4-E[PEG4-c(RGDfK)]2 (Tc-3PRGD2) single-photon emission computed tomography (SPECT) imaging encouraged us to expand the use of this tracer. This case-control study aimed to evaluate the feasibility of Tc-3PRGD2 imaging for detecting choroidal melanoma (CM) and for monitoring tumor response to plaque brachytherapy (PB). Ten consecutive patients with CM who underwent Tc-3PRGD2 imaging before and 3 months after PB were reviewed. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810050-0001
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http://dx.doi.org/10.1097/MD.0000000000012441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200507PMC
October 2018
1 Read

Visual Outcome and Millimeter Incremental Risk of Metastasis in 1780 Patients With Small Choroidal Melanoma Managed by Plaque Radiotherapy.

JAMA Ophthalmol 2018 Dec;136(12):1325-1333

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Importance: Early detection of choroidal melanoma at a small tumor size is emphasized in the literature. However, there is little published information on the specific risks of plaque-irradiated small choroidal melanoma on visual acuity and metastasis.

Objective: To analyze outcomes of plaque radiotherapy for small choroidal melanoma 3 mm in thickness or less. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2018.3881DOI Listing
December 2018
9 Reads

Treating Small Choroidal Melanoma: Smaller Is Better.

JAMA Ophthalmol 2018 Dec;136(12):1333-1334

Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City.

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http://dx.doi.org/10.1001/jamaophthalmol.2018.3880DOI Listing
December 2018

Mortality after deferral of treatment or no treatment for choroidal melanoma.

Indian J Ophthalmol 2018 Oct;66(10):1395-1400

Jules Stein Eye Institute and Department of Ophthalmology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.

Purpose: To report mortality of patients who were eligible for enrollment in the Collaborative Ocular Melanoma Study (COMS) clinical trials of medium-sized choroidal melanoma or large-sized choroidal melanoma but chose to defer treatment or receive no melanoma treatment.

Design: Prospective nonrandomized multicenter cohort study as an adjunct to COMS randomized clinical trials.

Methods: Patient follow-up procedures included examinations, correspondence, telephone contacts, and National Death Index searches. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1499_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173014PMC
October 2018
9 Reads

Considerations for using Natalizumab treatment in patients with a history of choroidal melanoma.

Mult Scler Relat Disord 2018 Nov 12;26:74-76. Epub 2018 Sep 12.

Prince Charles Eye Unit, King Edward VII Hospital, St. Leonard's Road, Windsor SL4 3DR, UK. Electronic address:

Natalizumab is a monoclonal antibody licensed for the treatment of relapsing-remitting multiple sclerosis (RRMS). It is known to increase the potential risk of developing progressive multifocal leukoencephalopathy (PML). There is current debate in the literature regarding its association with malignant melanoma. Read More

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http://dx.doi.org/10.1016/j.msard.2018.09.012DOI Listing
November 2018
3 Reads

Case Report: Importance of B-scan Ultrasonography for the Detection of Choroidal Melanoma.

Optom Vis Sci 2018 Oct;95(10):971-974

Murray Ocular Oncology and Retina, Miami, Florida

Significance: This case highlights the importance of using ultrasonography to evaluate an eye that has no clear view of the fundus.

Purpose: Uveal melanoma stems from melanocytes found in the iris, ciliary body, and choroid, and it is the most common primary intraocular malignancy found in adults. The lesion is identified predominantly via fundus biomicroscopy and binocular indirect ophthalmoscopy. Read More

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http://dx.doi.org/10.1097/OPX.0000000000001287DOI Listing
October 2018
2 Reads

Unilateral retinoblastoma with contralateral isolated choroidal Melanocytosis: case report of an unexpected presentation.

BMC Ophthalmol 2018 Sep 17;18(1):251. Epub 2018 Sep 17.

Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Background: Congenital ocular melanocytosis has been shown to be extremely uncommon in studies of numerous infants and children with retinoblastoma and disorders such as retinopathy of prematurity.

Case Presentation: A 33-month-old Caucasian boy presented with a solid white predominantly endophytic retinoblastoma filling most of the nasal aspect of the fundus and extensive vitreous seeding. Fundus exam of the contralateral eye showed a broad-based flat melanotic area of the choroid extending from the subfoveal region to the ora serrata temporally. Read More

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http://dx.doi.org/10.1186/s12886-018-0916-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142679PMC
September 2018
2 Reads

[Management of uveal melanomas, guidelines for oncologists].

Bull Cancer 2018 Oct 11;105(10):967-980. Epub 2018 Sep 11.

Centre François Baclesse, ARCHADE, service de radiothérapie, 3, avenue du général-Harris, 14000 Caen, France. Electronic address:

Uveal melanomas are the most frequent primary malignant eye tumor. Enucleation was historically the gold standard. Since then, several studies showed that conservative treatments did not increase the risk of metastasis or survival. Read More

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http://dx.doi.org/10.1016/j.bulcan.2018.07.011DOI Listing
October 2018
3 Reads

[Multimodal Imaging of the Choroidal Melanoma, with Differential Diagnosis, Therapy (Radiation Planning) and Follow-up].

Klin Monbl Augenheilkd 2018 Sep 14;235(9):1001-1012. Epub 2018 Sep 14.

Klinik und Poliklinik für Augenheilkunde, Charité - Universitätsmedizin Berlin, Berlin.

Imaging of intraocular tumors is multimodal, multi-purpose, and in continuous development. Therefore, imaging is indispensable for the detection, diagnosis, therapy and monitoring of intraocular tumours. A broad spectrum of imaging procedures is available for diagnostic testing and follow-up. Read More

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http://dx.doi.org/10.1055/a-0667-0806DOI Listing
September 2018

Cancers of the eye.

Cancer Metastasis Rev 2018 12;37(4):677-690

The New York Eye Cancer Center, Suite 5B, 115 East 61st Street, New York, NY, 10065, USA.

Ocular cancers are unique among the diseases of the eye, threatening both vision and life. In most cases, the diagnosis can be made utilizing a careful clinical history and specialized ocular examination. Eye cancer diagnosis relies heavily on imaging techniques such as high-frequency ultrasound, fluorescein angiography, anterior and posterior segment optical coherence tomography, computed tomography (CT), and magnetic resonance imaging (MRI). Read More

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http://link.springer.com/10.1007/s10555-018-9762-9
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http://dx.doi.org/10.1007/s10555-018-9762-9DOI Listing
December 2018
16 Reads

[Local treatment of choroidal melanoma: possibilities and limitations].

Authors:
A F Brovkina

Vestn Oftalmol 2018 ;134(4):52-60

Russian Medical Academy of Postgraduate Education, Ministry of Health of the Russian Federation, 2/1 Barrikadnaya St., Moscow, Russian Federation, 123995.

Local treatment of choroidal melanoma (CM) attracts the attention of many ophthalmology specialists, especially in recent years as the capabilities to target irradiation at small objects and possibilities of surgical interventions on the eyeball have expanded. The article discusses the medical indications for local treatment of CM. Review of literature of the last 16 years and author's own observations on CM patients who underwent almost all kinds of conventional methods of local treatment allowed thorough analysis of indications and counter-indications for their usage. Read More

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http://dx.doi.org/10.17116/oftalma201813404152DOI Listing
January 2018
2 Reads