3,213 results match your criteria Melanoma Choroidal


Cesk Slov Oftalmol 2021 ;77(2):94-100

Uveal melanoma is the most common intraocular tumour in adults, it is a form of cancer that affects mostly older adults, as the average age at detection of this tumour is 60 years, but it can occur in any age group with no significant gender difference. However, uveal melanoma is very rare in children compared to the adult population, accounting for 1 % of all cases. In pediatric patients, malignant uveal melanoma is more frequently manifested during puberty, leading to speculation of an association between uveal melanoma and growth hormone levels. Read More

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January 2021

Impact of Therapy & Age in Choroidal Cancers: A Retrospective Cohort Analysis of 7722 Patients from a US National Database.

Clin Ophthalmol 2021 28;15:1763-1774. Epub 2021 Apr 28.

Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA.

Background: Collectively, choroidal cancers represent a vast array of histopathologically diverse constituencies with profound repercussions related to mortality and metastasis. Prognosticated factors provide utility in determining clinical management and outcome propensities. To date, measures to collectively characterize choroidal cancers as a class are not impressive. Read More

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Endometrial Mesonephric-like Adenocarcinoma Presenting as an Ocular Lesion: A Case Report.

Int J Gynecol Pathol 2021 May 3. Epub 2021 May 3.

Department of Pathology, St. Vincent's University Hospital (S.A.L.N., A.D., S.K., D.G.) UCD School of Medicine and Medical Specialties (S.K., R.M.V., J.C., D.G.) Departments of Gynecological Oncology (R.M.V.) Oncology (J.C.), St. Vincent's University Hospital.

Endometrial mesonephric-like carcinoma (ML-CA) is a recently recognized subtype of aggressive endometrial adenocarcinoma that is morphologically and immunophenotypically similar to mesonephric carcinoma but not typically associated with mesonephric remnants. Here, we report a case of 58-yr-old female who had a past medical history of fibroids and of irregular menstrual bleeding for ~20 yr who presented with visual disturbance. On further investigation, she was found to have a large choroidal peri-papillary tumor of the right eye. Read More

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Iatrogenic Ocular Surface Diseases Occurring during and/or after Different Treatments for Ocular Tumours.

Cancers (Basel) 2021 Apr 16;13(8). Epub 2021 Apr 16.

Service d'ophtalmologie, Ophtalmopôle de Paris, Hôpital Cochin, AP-HP, F-75014 Paris, France.

The ocular surface represents a finely regulated system that allows the protection of the eye. It is particularly susceptible to different treatments for intraocular tumours, such as uveal melanoma and conjunctival cancers. Traditionally, the management of ocular tumours depends on the characteristics of the lesion, and is based on a combination of selective surgery, topical chemotherapy, and/or radiotherapy delivered through different mechanisms (e. Read More

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Choroidal melanoma in phakomatosis pigmentovascularis with overlapping Sturge-Weber syndrome and Klippel-Trenaunay syndrome.

Retin Cases Brief Rep 2021 Apr 16. Epub 2021 Apr 16.

From the Ocular Oncology Service, Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Purpose: T' trunk, along with hemi-hypertrophy of the left side of the face and left upper limb, presented for evaluation of an intraocular mass of the left eye (OS). Anterior examination OS showed diffuse episcleral and iris melanocytosis. Fundus examination OS showed diffuse choroidal melanocytosis as well as an elevated choroidal lesion. Read More

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Intra-operative ocular ultrasonography of iodine-125 brachytherapy plaques in patients with uveal melanoma.

J Contemp Brachytherapy 2021 Apr 14;13(2):126-134. Epub 2021 Apr 14.

Unidad de Retina Quirúrgica y Tumores Intraoculares del Adulto, Spain.

Purpose: Brachytherapy with iodine-125 (I) has been extensively used as a conservative treatment for uveal melanoma (UM). Surgical technique for correct placement of episcleral radioactive plaques (ERP) in UM cases with posterior choroidal location and/or small size can be difficult and inaccurate. In this study, the correct positioning of plaques was assessed by intra-operative ultrasound control. Read More

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[Results of optical coherence tomography angiography in choroidal melanoma].

A S Stoyukhina

Vestn Oftalmol 2021 ;137(2):18-25

Research Institute of Eye Diseases, Moscow, Russia.

Blood supply is known to be required for tumor growth and metastasis, and the formation of the tumor's own vasculature plays a critical role in the development of solid neoplasms. The method of optical coherence tomography angiography (OCTA) is considered promising for the study of angioarchitectonics.

Purpose: To evaluate the OCTA signs of choroidal melanoma (CM) depending on its sizes. Read More

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Plaque brachytherapy for choroidal melanoma with vitreous haemorrhage: a therapeutic challenge.

BMJ Case Rep 2021 Apr 13;14(4). Epub 2021 Apr 13.

Department of Radiodiagnosis, Government Medical College and Hospital, Chandigarh, India.

A 47-year-old man presented with profound loss of vision in right eye and relative afferent pupillary defect. On fundus examination, posterior pole details were obscured due to dense vitreous haemorrhage. B-scan ultrasonography was performed that revealed a mushroom-shaped hyperechoic lesion with medium internal reflectivity on A-scan ultrasonography. Read More

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Optic disc melanocytoma: a case report.

Rom J Ophthalmol 2021 Jan-Mar;65(1):89-92

Department of Ophthalmology, Government Medical College and Hospital, Chandigarh, India.

Often misdiagnosed as melanoma, melanocytoma of the optic disc is a rare benign ocular lesion that requires minimal active intervention, but demands a life time follow-up. We present a case of a 32-year-old man who was referred to our institute for the management of choroidal melanoma of the optic disc, which was detected by chance when the patient presented to a general ophthalmologist with chief complaint of itching in both eyes. The patient had normal visual acuity and fundoscopy revealed classical optic disc melanocytoma. Read More

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Association of TYRP1 with hypoxia and its correlation with patient outcome in uveal melanoma.

Clin Transl Oncol 2021 Apr 3. Epub 2021 Apr 3.

Department of Ocular Pathology, Dr.R.P.Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: Molecular mechanisms of uveal melanoma development in association with high pigmentation are unclear. Tyrosinase Related Protein (TYRP1) is not only one of the important melanogenesis marker that contributes to melanin synthesis, but can also prevents the melanocyte death. The induction of melanogenesis leads to induction of HIF-1α which can affect the behavior of melanoma cells and its surrounding environment. Read More

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Acute exudative polymorphous paraneoplastic vitelliform maculopathy (AEPPVM) associated with choroidal melanoma.

Int J Retina Vitreous 2021 Apr 1;7(1):27. Epub 2021 Apr 1.

Ophthalmology Department, Federal University of São Paulo (Unifesp-EPM), Rua Botucatu, 822, São Paulo, SP, 04023-062, Brazil.

Background: To report a case of acute exudative polymorphous paraneoplastic vitelliform maculopathy in a patient with a history of choroidal melanoma, with metastases to the pancreas, liver, and central nervous system.

Case Presentation: A 63-year-old patient, with a history of enucleation of the right eye due to choroidal melanoma, complained of progressive visual loss during a follow-up visit. Fundoscopic examination revealed multiple small areas of serous retinal detachment scattered throughout the posterior pole and ancillary tests confirmed the diagnosis of acute exudative polymorphous paraneoplastic vitelliform maculopathy (AEPPVM). Read More

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MRI and dual-energy CT fusion anatomic imaging in Ru-106 ophthalmic brachytherapy.

Brachytherapy 2021 Mar 27. Epub 2021 Mar 27.

Department of Ophthalmology, University Hospital of Heraklion, Crete, Greece.

Purpose: Brachytherapy with Ru-106 is widely used for the treatment of intraocular tumors, and its efficacy depends on the accuracy of radioactive plaque placement. Ru-106 plaques are MRI incompatible and create severe metal artifacts on conventional CT scans. Dual-energy CT scans (DECT) may be used to suppress such artifacts. Read More

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Choroidal nevus with retinal invasion, clinical and imaging features.

Am J Ophthalmol Case Rep 2021 Jun 14;22:101059. Epub 2021 Mar 14.

Department of Ophthalmology, Duke University, Durham, NC, USA.

Purpose: To report a clinically challenging case of a choroidal nevus with retinal invasion with accompanying ancillary testing.

Observations: A 60-year-old Caucasian female was referred for a suspicious melanocytic choroidal lesion in her left eye. Ophthalmoscopic examination revealed a melanocytic choroidal lesion, measuring 10 mm × 10 mm in basal diameter. Read More

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The role of melanocytes in the human choroidal microenvironment and inflammation: Insights from the transcriptome.

Pigment Cell Melanoma Res 2021 Mar 22. Epub 2021 Mar 22.

School of Optometry and Vision Science, University of NSW, Sydney, NSW, Australia.

The choroid within the human eye contains a rich milieu of cells including melanocytes. Human choroidal melanocytes (HCMs) absorb light, regulate free radical production, and were recently shown to modulate inflammation. This study aimed to identify key genes and pathways involved in the inflammatory response of HCMs through the use of RNA-seq. Read More

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Very late orbital recurrence of choroidal melanoma four decades post enucleation.

Eur J Ophthalmol 2021 Mar 11:11206721211001266. Epub 2021 Mar 11.

Unit of Ophthalmology, Department of Medicine, Surgery and Neuroscience, Azienda Ospedaliera Universitaria Senese, Siena, Italy.

Orbital recurrence of malignant choroidal melanoma is quite uncommon, occurring in about 3% of patients undergoing enucleation for large tumors. Orbital recurrences after more than 10 years from enucleation are even rarer. In literature, only few reports described orbital recurrence that occurred between 10 and 40 years after primary diagnosis. Read More

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Estimating malignancy risk of melanocytic choroidal tumours detected in the Australian National Eye Health Survey.

Clin Exp Optom 2021 Mar 2:1-5. Epub 2021 Mar 2.

Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.

: The malignant potential of choroidal melanocytic tumours detected incidentally in the community is thought to be low, but this has not been assessed using a validated screening tool. An accurate characterisation of the malignant potential of these lesions has implications for resource allocation, service provision, education, and training.: MOLES (Mushroom shape, Orange Pigment, Large size, Enlargement, and Subretinal fluid) categorises tumours as 'common naevus', 'low-risk naevus', 'high-risk naevus', and 'probable melanoma'. Read More

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Suprachoroidal Delivery of Small Molecules, Nanoparticles, Gene and Cell Therapies for Ocular Diseases.

Pharmaceutics 2021 Feb 22;13(2). Epub 2021 Feb 22.

Clearside Biomedical, 900 North Point Parkway, Suite 200, Alpharetta, GA 30005, USA.

Suprachoroidal drug delivery technology has advanced rapidly and emerged as a promising administration route for a variety of therapeutic candidates, in order to target multiple ocular diseases, ranging from neovascular age-related macular degeneration to choroidal melanoma. This review summarizes the latest preclinical and clinical progress in suprachoroidal delivery of therapeutic agents, including small molecule suspensions, polymeric entrapped small molecules, gene therapy (viral and nonviral nanoparticles), viral nanoparticle conjugates (VNCs), and cell therapy. Formulation customization is critical in achieving favorable pharmacokinetics, and sustained drug release profiles have been repeatedly observed for multiple small molecule suspensions and polymeric formulations. Read More

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February 2021

Current molecular and clinical insights into uveal melanoma (Review).

Int J Oncol 2021 04 2;58(4). Epub 2021 Mar 2.

Department of Ophthalmology, University of Catania, I‑95123 Catania, Italy.

Uveal melanoma (UM) represents the most prominent primary eye cancer in adults. With an incidence of approximately 5 cases per million individuals annually in the United States, UM could be considered a relatively rare cancer. The 90‑95% of UM cases arise from the choroid. Read More

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Predictive factors of radio-induced complications in 194 eyes undergoing gamma knife radiosurgery for uveal melanoma.

Acta Ophthalmol 2021 Feb 26. Epub 2021 Feb 26.

Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Background And Purpose: To report the factors predictive of radio-induced complications (i.e. radiation retinopathy [RR], radiation papillopathy [RP] and neovascular glaucoma [NVG]) in uveal melanoma (UM) patients undergoing gamma knife radiosurgery (GKR). Read More

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February 2021

Survival in small choroidal melanocytic lesions with risk factors managed by initial observation until detection of tumour growth.

Clin Exp Ophthalmol 2021 Apr 9;49(3):251-259. Epub 2021 Mar 9.

Department of Ophthalmology, Ocular Oncology and Vitreoretinal Service, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain.

Background: The main objective was to describe metastatic and survival rates in patients with small choroidal melanocytic lesions initially managed by observation.

Methods: Retrospective, observational study of consecutive cases recruited from 2001 through 2018, followed for a median (mean, range) of 81.0 (89. Read More

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Application of Multimodal and Molecular Imaging Techniques in the Detection of Choroidal Melanomas.

Front Oncol 2020 1;10:617868. Epub 2021 Feb 1.

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.

Choroidal melanomas are the most common ocular malignant tumors worldwide. The onset of such tumors is insidious, such that affected patients often have no pain or obvious discomfort during early stages. Notably, enucleation is required for patients with a severe choroidal melanoma, which can seriously impact their quality of life. Read More

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February 2021

Response to Treatment with an Anti-Interleukin-6 Receptor Antibody (Tocilizumab) in a Patient with Hemophagocytic Syndrome Secondary to Immune Checkpoint Inhibitors.

Case Rep Oncol Med 2021 12;2021:6631859. Epub 2021 Feb 12.

Department of Medical Oncology, University Healthcare Complex of Salamanca, Paseo de San Vicente, 182, CP 37007 Salamanca, Spain.

. Immunotherapy represents one of the fundamental treatments in the management of some types of cancer, especially malignant melanoma. Toxicity derived from increased immune system activity can manifest in multiple organs and systems. Read More

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February 2021

Venous-air embolism during vitrectomy for endoresection of choroidal melanoma: Case report.

Eur J Ophthalmol 2021 Feb 24:1120672121995101. Epub 2021 Feb 24.

Asociación para Evitar la Ceguera Hospital IAP Dr Luis Sánchez Bulnes, Mexico City, Mexico.

Introduction: The purpose of this study is to report a case of venous-air embolism during a vitrectomy for endoresection of choroidal melanoma.

Case Description: A 31-year-old man went to the clinic because of photopsias and vision loss in his right eye. On fundoscopy of the right eye, a choroidal mass with an associated retinal detachment was found near the inferotemporal vascular arcade. Read More

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February 2021

Choroidal melanoma treatment in times of coronavirus disease 2019.

Melanoma Res 2021 04;31(2):194-195

Radiation Oncology Service, Tecnologico de Monterrey/Hospital Zambrano-Hellion, Monterrey, Nuevo Leon, Mexico.

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Histologic Findings of Choroidal Vasculopathy in Eyes Enucleated following Radiation Therapy for Uveal Melanoma: Radiation Choroidopathy.

Klin Monbl Augenheilkd 2021 Feb 22. Epub 2021 Feb 22.

Ophthalmology and Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States.

Introduction: Little has been published about the choroidal vascular changes that occur years after radiation exposure. The aim of this study was to review the histological changes observed in the choroidal vasculature following radiotherapy for uveal melanoma.

Methods: Records from a single institution were retrospectively reviewed from June 7, 2007 to June 7, 2017; 101 patients with a diagnosis of uveal melanoma that underwent enucleation had their records reviewed. Read More

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February 2021

Prognostic significance of regression and mitotic rate in head and neck cutaneous melanoma.

Laryngoscope Investig Otolaryngol 2021 Feb 16;6(1):109-115. Epub 2020 Dec 16.

Department of Otolaryngology-Head and Neck Surgery University of Minnesota Minneapolis Minnesota USA.

Importance: While regression is a commonly reported microscopic feature of melanoma, its prognostic significance is unclear.

Objective: To examine the impact of regression on sentinel node status and the likelihood of recurrence in primary cutaneous melanoma of the head and neck.

Design: Retrospective analysis of 191 adults who underwent surgical management for primary cutaneous melanoma of the head and neck between May 2002 and March 2019. Read More

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February 2021

Effect of luteolin on apoptosis and vascular endothelial growth factor in human choroidal melanoma cells.

Int J Ophthalmol 2021 18;14(2):186-193. Epub 2021 Feb 18.

Nanchang University, Nanchang 330000, Jiangxi Province, China.

Aim: To investigate the effects of luteolin on apoptosis, the cell cycle, and the expression and secretion of vascular endothelial growth factor (VEGF) in human choroidal melanoma cells (C918 and OCM-1).

Methods: C918 and OCM-1 cells cultured were treated with various concentrations of luteolin (0, 5, 10, 15 µmol/L). Cell growth was observed with an inverted microscope, and cell cycle arrest was detected by propidium iodide (PI) staining using flow cytometry. Read More

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February 2021

Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma.

BMC Cancer 2021 Feb 15;21(1):164. Epub 2021 Feb 15.

Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands.

Background: Activating Gα signalling mutations are considered an early event in the development of uveal melanoma. Whereas most tumours harbour a mutation in GNAQ or GNA11, CYSLTR2 (encoding G-protein coupled receptor CysLTR) forms a rare alternative. The role of wild-type CysLTR in uveal melanoma remains unknown. Read More

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February 2021