3,078 results match your criteria Melanoma Choroidal


Managing patients with choroidal melanoma in the COVID-19 era: a personal perspective.

Authors:
Bertil Damato

Br J Ophthalmol 2020 May 20. Epub 2020 May 20.

Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK

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http://dx.doi.org/10.1136/bjophthalmol-2020-316686DOI Listing

Effect of plaque brachytherapy dose and dose rate on risk for disease-related mortality in 1238 patients with choroidal melanoma.

Br J Ophthalmol 2020 May 19. Epub 2020 May 19.

St. Erik Eye Hospital, Stockholm, Sweden.

Background: Episcleral brachytherapy is the most common treatment for medium-sized choroidal melanomas. Although controversial, inadequate brachytherapy dose and dose rates have at least a hypothetical implication on patient survival.

Methods: All patients who received ruthenium-106 or iodine-125 brachytherapy for choroidal melanoma at St. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315722DOI Listing

Adenoma and Adenocarcinoma of the Retinal Pigment Epithelium: A Review of 51 Consecutive Patients.

Ophthalmol Retina 2020 Mar 18. Epub 2020 Mar 18.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:

Purpose: To describe the clinical and imaging characteristics, pathologic features, and management options of retinal pigment epithelium (RPE) adenoma/adenocarcinoma.

Design: Retrospective case series.

Participants: Fifty-one patients with RPE adenoma/adenocarcinoma. Read More

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http://dx.doi.org/10.1016/j.oret.2020.03.008DOI Listing

EXTENDED FIELD IMAGING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FOR THE STUDY OF RETINAL AND CHOROIDAL CHANGES AFTER RADIATION THERAPY FOR CHOROIDAL MELANOMA: Comparison With Wide-Field Angiography.

Retina 2020 May 11. Epub 2020 May 11.

Department of Biomedical and Clinical Science "Luigi Sacco," Eye Clinic, Luigi Sacco Hospital, University of Milan, Milan, Italy.

Purpose: Radiation retinopathy is a common side effect of ocular radiotherapy with no long-term effective therapy. Optical coherence tomography angiography (OCTA) and wide-field fluorescein angiography (FA) are widely used for the study of radiation maculopathy and peripheral nonperfusion, respectively. We investigated the role of extended field imaging (EFI-OCTA) for the study of retinal and choroidal alterations after radiotherapy for choroidal melanoma. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002848DOI Listing

Lower Levels of Adiponectin and Its Receptor Adipor1 in the Uveal Melanomas With Monosomy-3.

Invest Ophthalmol Vis Sci 2020 May;61(5):12

,.

Purpose: Adiponectin is an insulin-sensitizing and anticarcinogenic hormone that is encoded by a gene on chromosome 3. Here, we analyzed the expression of adiponectin and its receptor Adipor1 in primary uveal melanoma (UM) with regard to the monosomy-3 status and clinical factors, as well as the physiological response of UM cells to adiponectin.

Methods: Immunohistochemistry was performed on the primary UM of 34 patients. Read More

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http://dx.doi.org/10.1167/iovs.61.5.12DOI Listing

Wide-Field (15 × 9 mm) Swept-Source Optical Coherence Tomography Angiography Following Plaque Radiotherapy of Choroidal Melanoma: An Analysis of 105 eyes.

Asia Pac J Ophthalmol (Phila) 2020 May 4. Epub 2020 May 4.

From the Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA.

Purpose: The aim of this study was to evaluate retinal microvascular abnormalities following plaque radiotherapy of choroidal melanoma (CM) using wide-field swept-source optical coherence tomography angiography (OCTA).

Design: Single-centre retrospective review.

Methods: Retrospective case series of 105 CM patients treated with I-125 plaque radiotherapy and imaged with wide-field (15 × 9 mm) SS-OCTA from March 2018 to August 2018 at the Ocular Oncology Service, Wills Eye Hospital (Philadelphia, PA). Read More

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http://dx.doi.org/10.1097/APO.0000000000000282DOI Listing

Ultra-wide-field imaging assessment of small choroidal pigmented lesions using red and green colour channels.

Eye (Lond) 2020 May 4. Epub 2020 May 4.

Medical Retina Service/Ocular Oncology Service, Moorfields Eye Hospital, 162 City Road, London, EC1V 2PD, England, UK.

Background: Diagnosis of small choroidal melanoma is mainly based on tumour thickness, subretinal fluid, or lipofuscin pigment. Ultra-wide-field imaging (UWF) allows depiction of choroidal lesions through a red (RC) and a green channel (GC). Aim of the study was to determine the utility of this tool in the detection of small choroidal melanoma. Read More

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http://dx.doi.org/10.1038/s41433-020-0900-6DOI Listing
May 2020
1.897 Impact Factor

Not every pigmented tumour is melanoma: Adenoma of the ciliary body pigment epithelium.

Arch Soc Esp Oftalmol 2020 Apr 23. Epub 2020 Apr 23.

Departamento de Órbita y Oculoplástica, Fundación Hospital «Nuestra Señora de la Luz», IAP, Ciudad de México, México.

Differential diagnosis between a melanoma and a pseudomelanoma requires many years of experience and ocular studies, and requires paying attention to the smallest details. The case is presented of a 57 year-old male with an adenoma of the ciliary body pigment epithelium that was treated with an enucleation of the eye due to a suspicion of a choroidal melanoma. Read More

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http://dx.doi.org/10.1016/j.oftal.2020.03.009DOI Listing

Parsimonious Models for Predicting Mortality from Choroidal Melanoma.

Invest Ophthalmol Vis Sci 2020 Apr;61(4):35

,.

Purpose: To develop parsimonious models for estimating metastasis mortality in patients with choroidal melanoma for situations where use of the Liverpool Uveal Melanoma Prognosticator Online (LUMPO) or Tumor, Node, Metastasis (TNM) staging system is not possible.

Methods: A backward-selection algorithm identified largest basal tumor diameter (LBTD) and chromosome 3 status (C3S) as the most informative predictors of metastatic death. We defined two prognostic models, based on LBTD with or without known C3S, that took into account competing risks of death from other causes by using the Aalen estimator. Read More

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http://dx.doi.org/10.1167/iovs.61.4.35DOI Listing

Metastatic Choroidal Melanoma Treated with Ipilimimab.

Ophthalmology 2020 May;127(5):600

Medical College of Wisconsin, Milwaukee, Wisconsin.

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http://dx.doi.org/10.1016/j.ophtha.2020.01.020DOI Listing

Choroidal melanoma overlying scleral buckle evading detection treated with proton beam radiotherapy.

Am J Ophthalmol Case Rep 2020 Jun 8;18:100688. Epub 2020 Apr 8.

Ocular Oncology Service, Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.

Purpose: to present a case of a choroidal melanoma located along a scleral buckle contour and was successfully treated with proton beam radiotherapy, without disturbing the scleral buckle.

Observations: A 60-year-old woman presented with photopsias and history of retinal detachment repair with scleral buckle 36 years prior. She had annual dilated exams with her ophthalmologist over the last several years. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154985PMC

Ciliary Body Seeding after Pars Plana Transvitreal Fine-Needle Aspiration Biopsy of Choroidal Melanoma.

J Ophthalmic Vis Res 2020 Apr-Jun;15(2):252-255. Epub 2020 Apr 6.

Wills Eye Hospital, Ocular Oncology Service, Philadelphia, PA, USA.

Purpose: To report ciliary body seeding 20 years after pars plana transvitreal fine needle aspiration biopsy (FNAB) of choroidal melanoma.

Case Report: 67-year-old man with choroidal melanoma in left eye was previously managed with pars plana FNAB using a 25-gauge needle followed by plaque radiotherapy. Twenty years later, choroidal melanoma was regressed but there was a small flat focus of scleral pigment 3. Read More

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http://dx.doi.org/10.18502/jovr.v15i2.6744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151516PMC

Optical coherence tomography angiography in primary eye care.

Clin Exp Optom 2020 Apr 13. Epub 2020 Apr 13.

Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, Australia.

Optical coherence tomography angiography (OCT-A) is a non-invasive imaging modality for assessing the vasculature within ocular structures including the retina, macula, choroid and optic nerve. OCT-A has a wide range of clinical applications in various optometric conditions which have been independently reported in the literature. This paper aims to present a review of the current literature on the clinical application of OCT-A in optometric practice as well as to analyse and evaluate the quality of the available evidence. Read More

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http://dx.doi.org/10.1111/cxo.13068DOI Listing

Gamma Knife Radiosurgery for Uveal Melanoma: A Retrospective Review of Clinical Complications in a Tertiary Referral Center.

Ocul Oncol Pathol 2020 Mar 3;6(2):115-122. Epub 2019 Sep 3.

Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, Italy.

Introduction: Gamma knife radiosurgery (GKR) has shown promising results in the treatment of intraocular uveal melanoma (UM) in terms of local tumor control. However, GKR is not free from potentially sight-threatening side effects, including cataract, dry eye disease, vitreous hemorrhage, radiation retinopathy (RR), radiation maculopathy (RM), optic neuropathy, and neovascular glaucoma. The aim of this paper is to report our 20-year experience in UM management with GKR focusing on the rate of clinical treatment-induced complications. Read More

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http://dx.doi.org/10.1159/000501971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109381PMC

[Optical coherence tomography in diagnostics of small choroidal melanoma].

Vestn Oftalmol 2020 ;136(1):56-64

Helmholtz National Medical Research Center of Eye Diseases, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062.

Purpose: To determine signs of small choroidal melanoma with different pigmentation using enhanced depth imaging optical coherence tomography (EDI-OCT).

Material And Methods: The study included 344 patients with small choroidal melanoma with different pigmentation examined using EDI-OCT: 1st group - pigmented melanoma (228 eyes), 2nd group - low pigmented (65 eyes), and 3rd group - amelanotic (51 eyes).

Results: In pigmented small choroidal melanomas - elevation of choroidal profile towards vitreous, compression of choriocapillaries with a narrow even 'belt' and a 'shadow' effect; thinning, defects in Bruch's membrane; thickening of the retina above the tumor, lobulated photoreceptors; intra- and subretinal exudate (diffuse, cystic edema, neuroepithelial detachment); defects and detachment of pigment epithelium with hyperreflective foci, disorganization of the pigment with the formation of hyperreflective foci at different retinal levels. Read More

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http://dx.doi.org/10.17116/oftalma202013601156DOI Listing

Fluorinated-functionalized hyaluronic acid nanoparticles for enhanced photodynamic therapy of ocular choroidal melanoma by ameliorating hypoxia.

Carbohydr Polym 2020 Jun 4;237:116119. Epub 2020 Mar 4.

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, China. Electronic address:

Photodynamic therapy (PDT) is a method for killing cancer cells by employing reactive singlet oxygen (O). However, the inherent hypoxia and oxygen consumption in tumors during PDT lead to a deficient oxygen supply, which in turn hinder the photodynamic efficacy. To overcome this issue, fluorinated-functionalized polysaccharide-based nanocomplexes were prepared by anchoring perfluorocarbons (PFCs) and pyropheophorbide a (Ppa) onto the polymer chains of hyaluronic acid (HA) to deliver O in hypoxia area. Read More

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http://dx.doi.org/10.1016/j.carbpol.2020.116119DOI Listing

Leptomeningeal Seeding in Choroidal Melanoma after Enucleation Surgery.

Korean J Ophthalmol 2020 Apr;34(2):176-177

Department of Ophthalmology, Institute of Vision Research, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3341/kjo.2019.0101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105793PMC

Naevus of Ota: clinical characteristics and proposal for a new ocular classification and grading system.

Br J Ophthalmol 2020 Mar 30. Epub 2020 Mar 30.

Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel.

Introduction: Naevus of Ota is a congenital condition that may involve the skin, eyeball and even intracranial structures usually in the distribution of the ophthalmic and maxillary divisions of the trigeminal cranial nerve. The purpose of this study was to summarise our experience with the ocular clinical presentation, imaging, outcome, treatment of complications and to offer a new classification of patients with naevus of Ota.

Methods: We retrospectively reviewed the patients' medical records and the following parameters were retrieved and analysed: demographics, clinical presentation complications and treatment of complications. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-313984DOI Listing

An amelanotic choroidal melanoma arising in a young man with tattoo-associated sarcoidosis.

Am J Ophthalmol Case Rep 2020 Jun 7;18:100655. Epub 2020 Mar 7.

Tennessee Retina, PC, Nashville, TN, USA.

Purpose: To describe a patient with an amelanotic choroidal melanoma, originally misdiagnosed as a choroidal granuloma, following his systemic diagnosis of tattoo-associated sarcoidosis.

Observations: The amelanotic choroidal tumor, suspected to be a granuloma, failed initial steroid treatment. Full-thickness chorioretinal biopsy demonstrated histologic presence of uveal melanoma and tumor genetics via GEP analysis demonstrated a PRAME negative, Class 1A lesion. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082514PMC

The COMS Randomized Trial of Iodine 125 Brachytherapy for Choroidal Melanoma: IV. Local Treatment Failure and Enucleation in the First 5 Years after Brachytherapy. COMS Report No. 19.

Ophthalmology 2020 Apr;127(4S):S148-S157

Department of Ophthalmology, University of Washington, Seattle, Washington.

Objective: To describe the frequency and predictors of local treatment failure and enucleation after iodine 125 (I) brachytherapy in patients with choroidal melanoma treated and followed up in a large randomized clinical trial.

Design: Prospective, noncomparative, interventional case series within a randomized, multicenter clinical trial.

Participants: Patients enrolled in the Collaborative Ocular Melanoma Study (COMS) trial of enucleation versus brachytherapy between February 1987 and July 1998; tumors measured 2. Read More

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http://dx.doi.org/10.1016/j.ophtha.2020.01.032DOI Listing

Glaucoma as the presenting sign of intraocular tumors: beware of the masquerading sign.

Int Ophthalmol 2020 Mar 20. Epub 2020 Mar 20.

Ophthalmic Plastic Surgery and Ocular Oncology Services, The Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, 500034, India.

Purpose: To discuss the clinical presentation and management of intraocular tumors masquerading as primary glaucoma or non-tumor-related secondary glaucoma.

Methods: Retrospective chart review.

Results: Ten patients with unsuspected intraocular tumor were referred to glaucoma clinic with a diagnosis of primary glaucoma or non-tumor-related secondary glaucoma. Read More

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http://dx.doi.org/10.1007/s10792-020-01348-xDOI Listing

Checkpoint inhibitor-induced sarcoid choroidal granulomas.

Am J Ophthalmol Case Rep 2020 Jun 6;18:100652. Epub 2020 Mar 6.

Massachusetts Eye and Ear, Department of Ophthalmology, Retina Service, Harvard Medical School, Boston, MA, USA.

Purpose: To present a novel case of sarcoid choroidal granulomas due to nivolumab therapy for metastatic cutaneous melanoma.

Observations: A 55 year-old male with a history of stage III metastatic cutaneous melanoma treated by nivolumab presented with bilateral choroidal lesions. The ophthalmologic examination revealed bilateral creamy, yellow choroidal lesions with no ocular inflammation. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075746PMC

Variable Presentations of Peripheral Exudative Hemorrhagic Chorioretinopathy.

Middle East Afr J Ophthalmol 2019 Oct-Dec;26(4):253-256. Epub 2020 Jan 29.

Vitreoretinal Division, King Khaled Eye Specialist Hospital (KKESH), Riyadh, Saudi Arabia.

Three cases of peripheral exudative hemorrhagic chorioretinopathy (PEHCR), which mimicked other retinal pathologies, were reported. Different preliminary diagnoses were made initially, but thorough examination combined with the appropriate investigations led to the final diagnosis of PEHCR. Despite the rare occurrence of PEHCR, it must be included in the differential diagnosis for peripheral retinal diseases. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_138_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034151PMC

DNA damage response proteins and its role in tumor progression of uveal melanoma with patient outcome.

Clin Transl Oncol 2020 Mar 2. Epub 2020 Mar 2.

Department of Ophthalmology, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Background: The role of DNA damage response (DDR) proteins is poorly understood in uveal melanoma. ATR belongs to one of those proteins that induce DDR by arresting the cell cycle which leads to DNA repair. ATR is localized at position 23 on the same chromosome 3 where BAP1 is located at position 21. Read More

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http://dx.doi.org/10.1007/s12094-019-02281-xDOI Listing

Influence of Ranibizumab versus laser photocoagulation on radiation retinopathy (RadiRet) - a prospective randomized controlled trial.

Graefes Arch Clin Exp Ophthalmol 2020 Apr 28;258(4):869-878. Epub 2020 Feb 28.

Department of Ophthalmology, Charité University Medicine Berlin, Hindenburgdamm 30, 12200, Berlin, Germany.

Purpose: To demonstrate superiority of intravitreal ranibizumab 0.5 mg compared to focal and peripheral laser treatment in patients with radiation retinopathy for choroidal melanoma.

Methods: Inclusion criteria were as follows: patients with radiation retinopathy and visual acuity impairment due to radiation maculopathy accessible for laser therapy, age ≥ 18 years, and BCVA less than 20/32. Read More

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http://dx.doi.org/10.1007/s00417-020-04618-7DOI Listing

Comparison of Iodide-125 and Ruthenium-106 Brachytherapy in the Treatment of Choroidal Melanomas.

Clin Ophthalmol 2020 4;14:339-346. Epub 2020 Feb 4.

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, IR, Iran.

Background: To compare iodine-125 (I) with ruthenium-106 (Ru) episcleral plaque radiation therapy in terms of the effectiveness and non-inferiority for choroidal melanoma treatment.

Objective: To report the non-inferiority of new made iodine-125 (I) compared with ruthenium-106 (Ru) episcleral plaque radiation.

Patients And Methods: A retrospective, non-randomized comparative case series. Read More

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http://dx.doi.org/10.2147/OPTH.S235265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007774PMC
February 2020

Multimodal Imaging in a Case of Localized Suprachoroidal Hemorrhage.

J Ophthalmic Vis Res 2020 Jan-Mar;15(1):104-108. Epub 2020 Feb 2.

Smt Kanuri Santhamma Center for Vitreo Retina Services, L. V. Prasad Eye Institute, Hyderabad, India.

Purpose: To report a case of localized suprachoroidal hemorrhage presenting as a choroidal mass.

Case Report: A 66-year-old woman presented with sudden onset pain in the right eye, one week following uneventful cataract surgery. The best corrected visual acuity (BCVA) was 20/160 and fundus examination showed a brown elevated choroidal mass temporal to the fovea in the right eye with normal retina and retinal vessels over it. Read More

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http://dx.doi.org/10.18502/jovr.v15i1.5956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001026PMC
February 2020

Multicenter External Validation of the Liverpool Uveal Melanoma Prognosticator Online: An OOG Collaborative Study.

Cancers (Basel) 2020 Feb 18;12(2). Epub 2020 Feb 18.

Liverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, L7 8TX, UK.

Uveal melanoma (UM) is fatal in ~50% of patients as a result of disseminated disease. This study aims to externally validate the Liverpool Uveal Melanoma Prognosticator Online V3 (LUMPO3) to determine its reliability in predicting survival after treatment for choroidal melanoma when utilizing external data from other ocular oncology centers. Anonymized data of 1836 UM patients from seven international ocular oncology centers were analyzed with LUMPO3 to predict the 10-year survival for each patient in each external dataset. Read More

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http://dx.doi.org/10.3390/cancers12020477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072188PMC
February 2020

ECHO-7 oncolytic virus Rigvir® in an adjuvant setting for stage I uveal melanoma; A retrospective case report.

Am J Ophthalmol Case Rep 2020 Mar 31;17:100615. Epub 2020 Jan 31.

Rigvir, Rīga, Latvia.

Purpose: To describe a case of choroidal melanoma treated with Rigvir® virotherapy in an adjuvant setting.

Observations: A female patient born in 1956 presented with a small choroidal melanoma in October 2007. 34 months after transpupillary thermotherapy the state of her eye worsened until tumor growth was visualized. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011033PMC

[Choroidal melanoma and retinal changes].

Vestn Oftalmol 2019 ;135(6):4-10

S.P. Botkin Moscow City Clinical Hospital, Branch No. 1, Ophtalmooncology department, 7 Mamonovskiy Lane, Moscow, Russian Federation, 123001.

Literary sources suggest the existence of a new phenotype - retinoinvasive choroidal melanoma (CM). However, the factual evidence of its spreading over the inner retinal surface cannot be dismissed.

Purpose: To study the capabilities of optical coherence tomography (OCT) in terms of finding the ways CM spreads into the retina based on pathomorphological examination of the eyes enucleated due to CM. Read More

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http://dx.doi.org/10.17116/oftalma20191350614DOI Listing
February 2020

Histopathologic Patterns of Recurrent Choroidal Melanoma Following I-125 Plaque Brachytherapy.

Ocul Oncol Pathol 2020 Jan 18;6(1):50-57. Epub 2019 Jun 18.

Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Purpose: Histologic correlation of clinical patterns of recurrent choroidal melanoma following I-125 plaque brachytherapy was performed to identify pathologic mechanisms of recurrence.

Methods: We reviewed 7 cases of recurrent choroidal melanoma following I-125 plaque brachytherapy managed with enucleation. Clinical characteristics included tumor dimensions, radiation dose, time to local recurrence, and clinical pattern of recurrence. Read More

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http://dx.doi.org/10.1159/000500446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984146PMC
January 2020

Choroidal Melanoma Simulating Adenoma of the Retinal Pigment Epithelium Arising at the Site of Congenital Hypertrophy of the Retinal Pigment Epithelium.

Ocul Oncol Pathol 2020 Jan 30;6(1):39-43. Epub 2019 Jul 30.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Neoplasms of the retinal pigment epithelium (RPE) are rare tumors that can simulate choroidal melanoma, but clinical and imaging characteristics often differentiate these lesions. We report a 70-year-old male with an abruptly elevated pigmented lesion that arose at the site of congenital hypertrophy of the RPE and demonstrated associated exudation, as well as feeding and draining vessels, suggestive of RPE adenoma. Optical coherence tomography showed retinal elevation with serous retinal detachment adjacent to the mass, and ultrasonography revealed an abruptly elevated, moderately echodense mass of 6. Read More

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http://dx.doi.org/10.1159/000501084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984159PMC
January 2020

Choroidal Nevus and Melanoma in Patients with Oculocutaneous Albinism.

Ocul Oncol Pathol 2020 Jan 10;6(1):31-34. Epub 2019 Jul 10.

Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, India.

Background: There are limited reports of uveal "melanocytic" lesions in patients with oculocutaneous albinism, with no reports from Asia.

Objectives: In this study, we report 3 eyes with uveal "melanocytic" lesions in Asian patients with oculocutaneous albinism.

Methods: Retrospective small case series. Read More

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http://dx.doi.org/10.1159/000500784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984154PMC
January 2020

3D Wrap Ultra-Widefield Reconstruction in Stereotactic Radiosurgery for Choroidal Melanoma.

Ocul Oncol Pathol 2020 Jan 12;6(1):20-24. Epub 2019 Jun 12.

Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, Italy.

Choroidal melanoma (CM) is the most commonly diagnosed primary intraocular malignancy in adults. Gamma knife radiosurgery (GKR) has demonstrated reliable results in the treatment of CM, but it is limited by the risk of radiation-induced ocular complications. To optimize the dose of radiation focused on the tumor, and limit side effects, the eye should be properly immobilized before treatment. Read More

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http://dx.doi.org/10.1159/000500312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984162PMC
January 2020

Germline Mutation Associated with Bilateral Primary Uveal Melanoma.

Ocul Oncol Pathol 2020 Jan 4;6(1):10-14. Epub 2019 Jun 4.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Purpose: To describe the occurrence of bilateral primary uveal melanoma in 2 patients with mutation on the gene encoding BRCA1-associated protein 1 .

Methods: Retrospective chart review of patients with bilateral primary uveal melanoma and subsequent positive germline mutation.

Results: There were 2 patients with bilateral uveal melanoma and germline positivity. Read More

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http://dx.doi.org/10.1159/000499570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984137PMC
January 2020

ELF1-mediated LUCAT1 promotes choroidal melanoma by modulating RBX1 expression.

Cancer Med 2020 Mar 22;9(6):2160-2170. Epub 2020 Jan 22.

Tianjin Medical University Eye Hospital, Tianjin, China.

Long noncoding RNAs (lncRNAs) are essential regulators of gene expression and biological behaviors. However, the contribution of lncRNA LUCAT1 to choroidal melanoma (CM) remains unexplored. Here, we examined the expression of LUCAT1 in CM cells by qRT-PCR and investigated its biological effects by cell counting kit-8, EdU, TUNEL, transwell assays, and Western blot. Read More

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http://dx.doi.org/10.1002/cam4.2859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064025PMC

Orbital exenteration and conjunctival melanoma: a 14-year study at the Jules Gonin Eye Hospital.

Eye (Lond) 2020 Jan 20. Epub 2020 Jan 20.

Ophthalmology Department, Jules Gonin Eye Hospital, Lausanne, Switzerland.

Purpose: To report our 14-year experience with orbital exenteration and assess risk factors for poor prognosis by focusing on conjunctival melanoma.

Patients And Method: A retrospective study was conducted in our tertiary care centre (Jules Gonin Eye Hospital, Lausanne, Switzerland) between 2003 and 2017. Inclusion criteria were patients aged  ≥18 years with a follow-up >12 months, without metastatic spread at the time of surgery. Read More

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http://dx.doi.org/10.1038/s41433-020-0767-6DOI Listing
January 2020

Blue-Light Fundus Autofluorescence Imaging following Ruthenium-106 Brachytherapy for Choroidal Melanoma.

Ophthalmologica 2020 Jan 15:1-13. Epub 2020 Jan 15.

Department of Ophthalmology, DRK Kliniken Berlin Westend, Berlin, Germany,

Purpose: To describe changes in blue-light fundus autofluorescence (FAF) and corresponding alterations in optical coherence tomography (OCT) within the irradiation field after ruthenium-106 brachytherapy (RBT) for choroidal melanoma.

Methods: Consecutive patients with choroidal melanoma were included in a retrospective case series. Patients were treated with RBT at a single institution. Read More

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http://dx.doi.org/10.1159/000504715DOI Listing
January 2020

Intraocular leiomyoma: Current concepts.

Surv Ophthalmol 2020 Jul - Aug;65(4):421-437. Epub 2020 Jan 7.

The New York Eye and Ear Infirmary, Mount Sinai Hospital, New York, NY, USA.

Intraocular leiomyoma is a benign smooth muscle tumor. First recognized before the era of immunohistochemistry, uveal leiomyomas have been described in case reports and small case series. We add 3 new cases, for a total of 80. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.12.008DOI Listing
January 2020

Choroidal Metastasis From Melanoma Treated by Cyberknife Irradiation.

JAMA Ophthalmol 2020 Jan 9;138(1):e190388. Epub 2020 Jan 9.

Department of Radiation Therapy, Centre François Baclesse-ARCHADE, Unicaen-Normandie University, Caen, France.

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http://dx.doi.org/10.1001/jamaophthalmol.2019.0388DOI Listing
January 2020

Widefield imaging of retinal and choroidal tumors.

Int J Retina Vitreous 2019 12;5(Suppl 1):49. Epub 2019 Dec 12.

Department of Ophthalmology, Stanford University Byers Eye Institute, 2452 Watson Court MC 5353, Palo Alto, CA 94303 USA.

Background: Wide-field imaging plays an increasingly important role in ocular oncology clinics. The purpose of this review is to describe the commonly used wide-field imaging devices and review conditions seen in ocular oncology clinic that underwent wide-field imaging as part of the multimodal evaluation.

Summary Of Review: Wide-field or wide-angle imaging is defined as greater than 50° field of view. Read More

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http://dx.doi.org/10.1186/s40942-019-0196-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907111PMC
December 2019

RETINAL OXIMETRY IS ALTERED IN EYES WITH CHOROIDAL MELANOMA BUT NOT IN EYES WITH CHOROIDAL NEVI.

Retina 2019 Dec 17. Epub 2019 Dec 17.

Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.

Purpose: To compare retinal vessel oxygenation in eyes with an untreated choroidal nevus or choroidal melanoma.

Methods: The affected and fellow eye of patients with an untreated choroidal nevus (n = 42) or choroidal melanoma (n = 45) were investigated using noninvasive retinal oximetry (Oxymap T1). Oxygen saturation of arterioles (ArtSat) and venules (VenSat) was determined, together with the arteriovenous difference (AV-difference). Read More

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http://dx.doi.org/10.1097/IAE.0000000000002719DOI Listing
December 2019

[Tyrosine kinase inhibitor-associated choroidopathy].

Ophthalmologe 2019 Dec 16. Epub 2019 Dec 16.

Universitätsklinikum Halle (Saale), Universitätsklinik und Poliklinik für Augenheilkunde, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06120, Halle/Saale, Deutschland.

A 66-year-old male patient presented to the ophthalmology department with bilateral blurred vision, which had persisted for 1 week. Due to a pulmonary melanoma metastasis, the patient received a combination treatment with dabrafenib and trametinib. At the first presentation visual acuity was 1. Read More

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http://dx.doi.org/10.1007/s00347-019-00964-yDOI Listing
December 2019
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Distant metastasis in choroidal melanoma with spontaneous corneal perforation and intratumoral calcification: A case report.

World J Clin Cases 2019 Dec;7(23):4044-4051

Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan.

Background: Uveal melanoma is the most common primary intraocular malignancy in adults, but its incidence is low in Asian populations. Spontaneous corneal perforation and intratumoral calcification are rare presentations of choroidal melanoma (CM) , and reports regarding these presentations have been limited. Even after complete surgical treatment, the prognosis of CM patients is usually poor if distant metastasis is present. Read More

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http://dx.doi.org/10.12998/wjcc.v7.i23.4044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906580PMC
December 2019

[Does orbital exenteration still has a place in 2019?]

J Fr Ophtalmol 2020 Feb 9;43(2):152-174. Epub 2019 Dec 9.

Service de chirurgie oncologique cervico-faciale, centre Antoine Lacassagne, 06189 Nice, France.

Introduction: Orbital exenteration is a radical anatomically and psychologically disfiguring procedure. It is mostly performed for management of orbital cancers or cancers with orbital involvement. The lack of benefit in terms of overall survival and the development of new molecular therapies (targeted therapies, immunotherapy) in recent years leads us to question its use. Read More

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http://dx.doi.org/10.1016/j.jfo.2019.04.021DOI Listing
February 2020