2,951 results match your criteria Melanoma Choroidal


Distant Subconjunctival Recurrences following Proton Therapy for a Choroidal Melanoma with Extrascleral Extension.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):422-424. Epub 2019 Apr 18.

Jules-Gonin Eye Hospital, Department of Ophthalmology, University of Lausanne, FAA, Switzerland.

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http://dx.doi.org/10.1055/a-0796-6299DOI Listing

Vision loss with pembrolizumab treatment: A report of two cases.

J Oncol Pharm Pract 2019 Apr 18:1078155219841683. Epub 2019 Apr 18.

University of Kansas Medical Center, Kansas City, KS.

Background: Vision loss and other ocular toxicities are rare, but detrimental, side effects of immune checkpoint inhibitors. Herein, we report two patients who developed vision loss while on pembrolizumab treatment.

Cases Presentation: Case 1 - A 58-year-old man was started on pembrolizumab for advanced melanoma. Read More

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http://dx.doi.org/10.1177/1078155219841683DOI Listing
April 2019
1 Read

Expression of immune checkpoint receptors Indoleamine 2,3-dioxygenase and T cell Ig and ITIM domain in metastatic versus nonmetastatic choroidal melanoma.

Cancer Med 2019 Apr 16. Epub 2019 Apr 16.

Departments of Ophthalmology and Pathology, Emory University School of Medicine, Atlanta, Georgia.

Background: Survival in metastasized cutaneous melanoma (CM) has been improved with the advent of inhibitors of immune checkpoints CTLA4 and PD-1. In contrast, the response rate for inhibition of these checkpoints in uveal melanoma (UM) is very low. Other checkpoints including IDO and TIGIT may be targetable. Read More

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http://dx.doi.org/10.1002/cam4.2167DOI Listing
April 2019
1 Read

Metastatic Cutaneous Melanoma Presenting with Choroidal Metastasis Simulating Primary Uveal Melanoma.

Ocul Oncol Pathol 2019 Feb 8;5(2):135-138. Epub 2018 Aug 8.

Department of Ophthalmology, University of California, San Francisco, California, USA.

Purpose: To report a case of metastatic cutaneous melanoma presenting with choroidal metastasis simulating primary uveal melanoma.

Design: Case report.

Method: Presentation of clinical, radiographic, histopathologic, and tumor genetic findings in a patient with cutaneous melanoma with choroidal metastasis. Read More

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https://www.karger.com/Article/FullText/488708
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http://dx.doi.org/10.1159/000488708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422132PMC
February 2019
4 Reads

Gene Expression Profiling as an Adjunctive Measure to Guide the Management of Indeterminate, High-Risk Choroidal Melanocytic Lesions: A Pilot Study.

Ocul Oncol Pathol 2019 Feb 12;5(2):102-109. Epub 2018 Jul 12.

Department of Oncology, University of Alberta, Edmonton, Alberta, Canada.

Purpose: To describe our early experience with gene expression profiling (GEP) assessment for juxtafoveal, subfoveal, and peripapillary indeterminate high-risk melanocytic lesions to assist in making early treatment decisions in patients who did not feel comfortable with either close observation or definitive treatment.

Methods: A prospective cohort of patients with indeterminate lesions who underwent GEP were enrolled. Nonparametric statistical analysis was utilized given the small sample size. Read More

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http://dx.doi.org/10.1159/000490252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422137PMC
February 2019

Ipsilateral metastatic choroidal melanoma responds to systemic immunotherapy.

Eur J Ophthalmol 2019 Apr 4:1120672119839925. Epub 2019 Apr 4.

1 The New York Eye Cancer Center, New York, NY, USA.

Purpose:: To report that metastatic choroidal melanoma (systemic and intraocular) can respond to systemic immunotherapy.

Methods:: In 2010, a 64-year-old woman with a choroidal melanoma was treated with palladium-103 plaque brachytherapy. Developing 2. Read More

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http://dx.doi.org/10.1177/1120672119839925DOI Listing
April 2019
2 Reads

Ruthenium-106 versus iodine-125 plaque brachytherapy of 571 choroidal melanomas with a thickness of ≥5.5 mm.

Br J Ophthalmol 2019 Mar 25. Epub 2019 Mar 25.

St. Erik Eye Hospital, Stockholm, Sweden

Background: Episcleral brachytherapy is the most common eye-preserving treatment for medium-sized choroidal melanomas. γ-emitting iodine-125 (I) and β-emitting ruthenium-106 (Ru) are widely used. The latter is however generally reserved for thinner tumours (<6 mm). Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313419DOI Listing

AUSTRALIAN AND NEW ZEALAND STUDY OF PHOTODYNAMIC THERAPY IN CHOROIDAL AMELANOTIC MELANOMA.

Retina 2019 Mar 19. Epub 2019 Mar 19.

Royal Victorian Eye and Ear Hospital, Victoria, Australia.

Purpose: To evaluate the safety and efficacy of primary photodynamic therapy (PDT) for posterior choroidal amelanotic melanomas.

Methods: Patients with posterior choroidal amelanotic melanomas up to 6 mm in height were treated with PDT using verteporfin as the photosensitizing agent. Treatment was repeated every 3 months until the tumor was flat up to a maximum of 6 treatments. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002520DOI Listing

Clinical and histopathological features of choroidal melanoma-related enucleated eyes in a Spanish tertiary hospital.

Arch Soc Esp Oftalmol 2019 Mar 21. Epub 2019 Mar 21.

Servicio de Oftalmología, Hospital Universitario La Paz, IdiPaz, Madrid, España.

Objective: To study clinical and pathological variables leading to a poor prognosis in a sample of uveal malignant melanoma patients who required eyeball enucleation as final treatment approach. All patients were seen and treated in the same public tertiary hospital in Madrid (Spain) within a 6-year time-period.

Materials And Methods: Longitudinal observational retrospective study. Read More

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http://dx.doi.org/10.1016/j.oftal.2018.12.005DOI Listing

CHOROIDAL NEVUS TRANSFORMATION INTO MELANOMA PER MILLIMETER INCREMENT IN THICKNESS USING MULTIMODAL IMAGING IN 2355 CASES: The 2019 Wendell L. Hughes Lecture.

Retina 2019 Mar 15. Epub 2019 Mar 15.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA. Dr. Dalvin has an appointment at the Department of Ophthalmology, Mayo Clinic, Rochester, MN.

Purpose: To analyze risk of nevus transformation into melanoma per millimeter increment.

Methods: Retrospective analysis of 3,806 choroidal nevi for transformation into melanoma per incremental millimeter thickness (flat [≤1.0 mm], thin [1. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002508DOI Listing

Small choroidal melanoma: detection with multimodal imaging and management with plaque radiotherapy or AU-011 nanoparticle therapy.

Curr Opin Ophthalmol 2019 May;30(3):206-214

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Purpose Of Review: To explore risk factors for choroidal nevus transformation into melanoma using multimodal imaging and review current treatment options.

Recent Findings: A recently published longitudinal study of 3806 choroidal nevi, imaged with optical coherence tomography (OCT), ultrasonography, and standard wavelength autofluorescence, revealed transformation into melanoma in 5.8% at 5 years and 13. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000560DOI Listing

[Optical coherence tomography angiography in ophthalmic oncology].

Vestn Oftalmol 2019;135(1):104-111

I.M. Sechenov First Moscow State Medical University, Department of Ophthalmology, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991.

The article reviews literature on various methods of optical coherence tomography (OCT). The review also describes clinical aspects of OCT angiography and its applications in ophthalmic oncology. Read More

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http://dx.doi.org/10.17116/oftalma2019135011104DOI Listing
January 2019
8 Reads

Choroidal Melanoma With Optic Nerve Infiltration Presenting as Orbital Pseudocellulitis.

Ophthalmic Plast Reconstr Surg 2019 Feb 21. Epub 2019 Feb 21.

The Operation Eyesight Universal Institute for Eye Cancer, and.

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http://dx.doi.org/10.1097/IOP.0000000000001328DOI Listing
February 2019
3 Reads

Retinal detachment with hemorrhagic intraretinal macrocyst clinically presenting as pseudo-choroidal melanoma.

Oman J Ophthalmol 2019 Jan-Apr;12(1):62-64

Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Medical Research Foundation, Chennai, Tamil Nadu, India.

A 23-year male with complaint of diminution of vision in left eye was referred to us as a suspect case of inflammatory choroidal mass/melanoma. Examination revealed a total retinal detachment with a reddish brown lesion in the superior hemi-fundus. B-scan ultrasonography demonstrated the 'mass' to be intra-retinal without choroidal involvement. Read More

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http://dx.doi.org/10.4103/ojo.OJO_136_2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380148PMC
February 2019

[UNUSUAL VITREOUS DETACHMENT].

Harefuah 2019 Feb;158(2):109-111

Ocular Oncology Service - The Goldschleger Eye Institute, Sheba Medical Center, Tel-Aviv University, Israel.

Introduction: A 49 years old patient with a history of brachytherapy for choroidal melanoma was referred to the ocular emergency room for suspected recurrence due to pigment in the vitreous cavity. On examination, pigmented vitreous secondary to posterior vitreous detachment with traction from the atrophic tumor was observed with no evidence of recurrence. Read More

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February 2019
2 Reads

THE SMALL FATAL CHOROIDAL MELANOMA STUDY A Survey by the European Ophthalmic Oncology Group.

Am J Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Ocular Oncology Service, Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Purpose: To determine the size at which choroidal melanomas can metastasize and to report the characteristics of small fatal choroidal melanomas (SFCM).

Design: Retrospective case series.

Methods: Ten ocular oncology services submitted 45 patients with a choroidal melanoma 3 mm or less in thickness and 9 mm or less in largest basal diameter (LBD), when treated, who developed metastases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394193006
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http://dx.doi.org/10.1016/j.ajo.2019.01.031DOI Listing
February 2019
14 Reads

Endogenous fluorescence can differentiate the keratoconic cornea.

Exp Eye Res 2019 Apr 5;181:178-184. Epub 2019 Feb 5.

Department of Biophysics and Molecular Physics, A. Chelkowski Institute of Physics, Silesian Center for Education and Interdisciplinary Research, University of Silesia, 41-500 Chorzów, 75 Pułku Piechoty 1A, Poland.

The purpose of the study was to investigate the endogenous fluorescence of the keratoconic cornea in order to analyze changes in the spectra due to the keratoconic stroma abnormalities. Twenty-two corneal buttons obtained from patients with keratoconus (KC, N = 22) at the time of penetrating keratoplasty were used. As a reference, twelve normal corneas (N = 12): ten from the Eye Bank and two from enucleated eyes due to choroidal melanoma were used. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144835183076
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http://dx.doi.org/10.1016/j.exer.2019.02.002DOI Listing
April 2019
12 Reads

Statins in ophthalmology.

Surv Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia.

Statins, 3-hydroxy-3-methyl-gutaryl coenzyme A reductase inhibitors, are a class of lipid-lowering drugs with anti-inflammatory, immunomodulatory, and vascular effects. Statins are increasingly being used in the treatment of a variety of medical conditions. We examine the actions of statins on the eye and its associated ophthalmic disorders. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.01.013DOI Listing
January 2019
8 Reads

The Amazon Ocular Oncology Center: The first three years.

Arq Bras Oftalmol 2019 Mar-Apr;82(2):107-110. Epub 2019 Jan 24.

Centro de Oncologia Ocular, Departamento de Ofalmologia e Ciências Visuais, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Purpose: To evaluate the first three years of The Amazon Ocular Oncology Center, the first ocular cancer center in the North of Brazil.

Methods: Here, we report patient information including patients' age, gender, diagnosis, treatment, and city of origin.

Results: Two hundred and twenty-one patients were included on this study: 160 (72%) patients came from the city of Manaus, 52 (24%) from other cities in Amazonas, and 9 (4%) from other states. Read More

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http://dx.doi.org/10.5935/0004-2749.20190024DOI Listing
January 2019
1 Read

Trends in Radiation Practices for Female Ocular Oncologists in North America: A Collaborative Study of the International Society of Ocular Oncology.

Ocul Oncol Pathol 2019 Jan 12;5(1):54-59. Epub 2018 Jun 12.

USC Roski Eye Institute, University of Southern California, Los Angeles, California, USA.

Background: The aim of this study was to determine the known radiation exposure, attitudes, and consequent risk modifications among female ocular oncologists in North America who routinely administer radioactive plaque brachytherapy treatment and are members of the International Society of Ocular Oncology.

Methods: Nineteen female ocular oncologists completed an anonymous 17-question radiation exposure survey.

Results: Eleven of the participants chose to routinely wear lead protection during surgery; 8 did not. Read More

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https://www.karger.com/Article/FullText/489219
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http://dx.doi.org/10.1159/000489219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341326PMC
January 2019
11 Reads

Outcomes of Glaucoma Drainage Device Surgery in Eyes with Treated Uveal Melanoma.

Ocul Oncol Pathol 2019 Jan 2;5(1):20-27. Epub 2018 May 2.

Stein Eye and Doheny Eye Institutes, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Aim: We report patient safety and intraocular pressure (IOP) control after placement of a glaucoma drainage device (GDD) in eyes with a history of treated malignant uveal melanoma.

Methods: A retrospective review of the records of patients with uveal melanoma was performed. Outcomes were local tumor recurrence, rate of metastases, and to-nometric success, based on survival curves, defined as IOP < 21 mm Hg. Read More

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https://www.karger.com/Article/FullText/488056
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http://dx.doi.org/10.1159/000488056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341335PMC
January 2019
9 Reads

Multifocal Primary Uveal Melanoma: Clinical and Molecular Characteristics.

Ocul Oncol Pathol 2019 Jan 27;5(1):8-12. Epub 2018 Apr 27.

Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

We report two patients who developed a second distinct choroidal melanoma in the same eye following successful regression of their first choroidal melanoma after iodine-125 plaque brachytherapy. Neither patient demonstrated ocular melanocytosis, local tumor recurrence, or vitreous seeding. One patient had the second tumor arising from a previously documented choroidal nevus, and after undergoing enucleation, there was no detectable connection between the tumors on histopathologic examination. Read More

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https://www.karger.com/Article/FullText/487891
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http://dx.doi.org/10.1159/000487891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341333PMC
January 2019
8 Reads

Outcomes of I-125 brachytherapy for uveal melanomas depending on irradiation dose applied to the tumor apex - a single institution study.

J Contemp Brachytherapy 2018 Dec 28;10(6):532-541. Epub 2018 Dec 28.

Department of Ophthalmology and Ocular Oncology of University Hospital, Cracow.

Purpose: The aim of the study was an evaluation of I-125 brachytherapy patients with uveal melanoma with special consideration for the relationship of the treatment results and the irradiation dose applied to the tumor apex.

Material And Methods: Medical records of 344 adults with uveal melanoma treated with I-125 brachytherapy in the Department of Ophthalmology and Ocular Oncology of the Jagiellonian University, Medical College in Cracow, Poland were retrospectively analyzed. The study was conducted between 2003 and 2012, and the study group was divided into two subgroups depending on the irradiation dose applied to the top of the tumor: 80 Gy to 100 Gy ( = 177) and 100 Gy to 120 Gy ( = 167). Read More

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http://dx.doi.org/10.5114/jcb.2018.79886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335559PMC
December 2018

Intraocular schwannoma: A case series of 3 patients.

Oncol Lett 2019 Jan 16;17(1):1274-1278. Epub 2018 Nov 16.

Department of Ophthalmology, Peking University People's Hospital, Beijing 100044, P.R. China.

Schwannoma is a proliferation of neoplastic Schwann cells. Schwannomas comprise 8-10% of all primary intracranial tumors. Primary intraorbital schwannoma arising from the ciliary nerves in the uvea, which accounts for 1-2% of all intracranial tumors, is a rare intraocular neoplasm. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9718
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http://dx.doi.org/10.3892/ol.2018.9718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313066PMC
January 2019
8 Reads

Late Apical Recurrence of Choroidal Melanoma 10 Years after Successful Treatment with Brachytherapy.

Ocul Oncol Pathol 2018 Jun 22;4(4):225-229. Epub 2017 Dec 22.

University of Southern California Roski Eye Institute, Los Angeles, CA, USA.

Purpose: To describe late apical relapse of a choroidal melanoma at the site of fine needle aspiration biopsy 10 years following successful treatment with I brachytherapy.

Methods: Retrospective case report of a 78-year-old male presenting 10 years following successful I brachytherapy for a choroidal melanoma with a medium-sized nodular amelanotic tumor recurrence at the site of the prior tumor biopsy.

Results: Fundus photography and B-scan ultrasound documented the findings at presentation at our institution. Read More

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https://www.karger.com/Article/FullText/485131
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http://dx.doi.org/10.1159/000485131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322081PMC
June 2018
14 Reads

Rare Occurrence of an Intraocular Choroidal Solitary Fibrous Tumor/Hemangiopericytoma.

Ocul Oncol Pathol 2018 Jun 16;4(4):213-219. Epub 2017 Dec 16.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Purpose: Tumors previously diagnosed as solitary fibrous tumors (SFT) and hemangiopericytomas (HPC) are characterized by the fusion gene, leading to nuclear STAT6 expression, and are now considered part of one SFT/HPC tumor entity by the 2016 World Health Organization Classification of Tumors of the Central Nervous System. We present the first primary choroidal SFT/HPC with the diagnosis confirmed by STAT6 expression.

Procedures: A 51-year-old man underwent enucleation for a choroidal mass, which revealed a spindle cell neoplasm involving the optic nerve, without extrascleral extension. Read More

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http://dx.doi.org/10.1159/000481947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322087PMC
June 2018
1 Read

CHOROIDAL MELANOMA DURING PREGNANCY: A CASE REPORT AND REVIEW OF THE LITERATURE.

Retin Cases Brief Rep 2019 Jan 11. Epub 2019 Jan 11.

Duke Eye Center, Duke University School of Medicine, Durham, North Carolina.

Purpose: To report a case of a woman diagnosed with choroidal melanoma during pregnancy, as well as review similar cases published in the literature. The prevalence, risk factors, treatment, prognosis, and outcomes of choroidal melanoma in pregnancy are addressed.

Methods: An extensive search of the literature was conducted by accessing PubMed, MEDLINE, and Scopus databases in January 2018 to identify cases of choroidal or uveal melanoma diagnosed during pregnancy. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000851DOI Listing
January 2019
7 Reads

Single-Stage Orbital Socket Reconstruction Using the Oversized Dermis Fat Graft and the 22 mm Silicone Orbital Implant after an Extended Enucleation.

Case Rep Ophthalmol Med 2018 4;2018:8954193. Epub 2018 Dec 4.

University Eye Clinic, Faculty of Dental Medicine and Health Care Osijek, Faculty of Medicine Osijek, University Josip Juraj Strossmayer in Osijek, University Hospital "Sveti Duh", Zagreb, Croatia.

We would like to present a surgical technique of orbital socket reconstruction using oversized dermis fat graft and 22 mm silicone orbital implant in a single-stage after extended enucleation in two patients with massive local recurrence of anteriorly located choroidal melanoma previously treated with endoresection. Orbital tissues en bloc were removed leaving conjunctival lining only at the fornices. Simultaneously, the 22 mm silicone sphere was implanted deeply into the orbit and covered with the oversized dermis fat graft of 30 mm in height and 35 mm in length with 20 mm of the fat thickness. Read More

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https://www.hindawi.com/journals/criopm/2018/8954193/
Publisher Site
http://dx.doi.org/10.1155/2018/8954193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304640PMC
December 2018
17 Reads

CHOROIDAL NEVUS IMAGING FEATURES IN 3,806 CASES AND RISK FACTORS FOR TRANSFORMATION INTO MELANOMA IN 2,355 CASES: The 2020 Taylor R. Smith and Victor T. Curtin Lecture.

Retina 2018 Dec 31. Epub 2018 Dec 31.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose: To use multimodal imaging for identification of risk factors for choroidal nevus transformation into melanoma.

Methods: Retrospective chart review of 3806 consecutive choroidal nevi with imaging and 2355 choroidal nevi with additional follow up to identify factors predictive of transformation of choroidal nevus into melanoma.

Results: The median patient age was 62. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002440DOI Listing
December 2018

Rhegmatogenous retinal detachment in a patient with choroidal melanoma simulating choroidal detachment: a case report.

J Med Case Rep 2018 Dec 25;12(1):389. Epub 2018 Dec 25.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.

Background: Ophthalmologists and retina specialists may consider choroidal detachment if patients with rhegmatogenous retinal detachment present with choroidal elevation. That misdiagnosis may lead to inappropriate treatments, development of tumor cell dissemination, and eventual promotion of patient death. We report a case of a patient with rhegmatogenous retinal detachment associated with choroidal melanoma simulating choroidal detachment according to fundus findings. Read More

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http://dx.doi.org/10.1186/s13256-018-1921-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305567PMC
December 2018
3 Reads

The Use of Intravitreal Anti-VEGF and Triamcinolone in the Treatment of Radiation Papillopathy.

Ocul Oncol Pathol 2018 Nov 8;4(6):395-400. Epub 2018 Jun 8.

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alberta, Canada.

Background/aims: To evaluate a treatment regimen for radiation papillopathy.

Methods: This is a prospective noncomparative interventional case series of patients who developed radiation papillopathy after plaque brachytherapy for uveal melanoma. Treatment consisted of intravitreal bevacizumab (IVB) (1. Read More

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http://dx.doi.org/10.1159/000487543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288662PMC
November 2018

Surface-Coil MRI for Small Peripheral Choroidal Melanoma: Imaging in a Rabbit Eye Model.

Ocul Oncol Pathol 2018 Nov 13;4(6):364-369. Epub 2018 Jun 13.

Department of Ophthalmology, University Hospital of Heraklion, Heraklion, Greece.

Introduction: Imaging of small peripheral choroidal melanomas remains challenging in clinical and experimental settings, requiring wide-field ophthalmoscopy modalities. In this study, we applied surface-coil MRI to assess imaging feasibility for small peripherally located choroidal melanoma in a rabbit eye model.

Methods: A female albino rabbit with a body weight of 2. Read More

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https://www.karger.com/Article/FullText/486789
Publisher Site
http://dx.doi.org/10.1159/000486789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288665PMC
November 2018
1 Read

Two Uveal Melanomas in One Eye: A Choroidal Nevus Giving Rise to a Melanoma in an Eye with a Separate Large Choroidal Melanoma.

Ocul Oncol Pathol 2018 Nov 2;4(6):355-358. Epub 2018 Mar 2.

Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Multifocal uveal melanomas are extremely rare. In this case report, we describe a patient with 2 independent uveal melanomas in the same eye. A 52-year-old woman presented with a large choroidal melanoma and a smaller ciliary body mass, clinically thought to be a nevus, in her left eye. Read More

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http://dx.doi.org/10.1159/000486682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288664PMC
November 2018
2 Reads

Kenalog modified by ionizing radiation induces intrinsic apoptosis mediated by elevated levels of reactive oxygen species in melanoma cancer.

Oncol Rep 2019 Mar 19;41(3):1837-1850. Epub 2018 Dec 19.

Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup‑si, Jeollabuk‑do 580‑185, Republic of Korea.

Kenalog is a synthetic glucocorticoid drug used to treat various cancers including ocular and choroidal melanoma. However, the drug achieves rarely sustainable results for patients. To overcome this difficulty, the structure of Kenalog was altered by ionizing radiation (IR) to develop a more effective anticancer agent for treatment of various skin cancers. Read More

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http://dx.doi.org/10.3892/or.2018.6940DOI Listing
March 2019
1 Read

Choroidal melanoma masquerading as orbital cellulitis.

BMJ Case Rep 2018 Dec 9;11(1). Epub 2018 Dec 9.

Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Orbital cellulitis is the most common subset of orbital inflammatory disease. We describe a patient with necrotic choroidal melanoma who presented with orbital cellulitis. MRI revealed a mass lesion suggesting intraocular melanoma with no extrascleral extension. Read More

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http://dx.doi.org/10.1136/bcr-2018-227486DOI Listing
December 2018
4 Reads

Glaucoma secondary to intraocular tumors: mechanisms and management.

Curr Opin Ophthalmol 2019 Mar;30(2):71-81

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose Of Review: Glaucoma secondary to intraocular tumors is important to consider in eyes with a known tumor and those with unilateral or refractory glaucoma. The purpose of this review is to discuss the mechanisms and management of intraocular tumors with related secondary glaucoma.

Recent Findings: Several intraocular tumors can lead to glaucoma, including iris melanoma, iris metastasis, iris lymphoma, trabecular meshwork melanoma, choroidal melanoma, choroidal metastasis, retinoblastoma, and medulloepithelioma. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000550DOI Listing
March 2019
13 Reads

Ocular ultrasound versus MRI in the detection of extrascleral extension in a patient with choroidal melanoma.

BMC Ophthalmol 2018 Dec 12;18(1):320. Epub 2018 Dec 12.

Department of Ophthalmology, University of Utah, Salt Lake City, UT, USA.

Background: To describe the superiority of ocular ultrasound in the diagnostic management of extrascleral extension in choroidal melanoma.

Case Presentation: We present a case of a 94-year-old male with choroidal melanoma of the right eye imaged with MRI and ocular ultrasound to aid in the detection of extrascleral extension.

Conclusions: With advancement in technology and new imaging modalities emerging, it can become difficult to determine the best diagnostic approach for patients. Read More

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http://dx.doi.org/10.1186/s12886-018-0990-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291956PMC
December 2018
2 Reads

Combination of multimodal imaging features predictive of choroidal nevus transformation into melanoma.

Br J Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Aim: To characterise combinations of multimodal imaging risk factors and predictive value for choroidal nevus transformation into melanoma.

Methods: This is a retrospective review of multimodal imaging features for 3806 choroidal nevi from 1 January 2007 through 1 January 2017. Kaplan-Meier estimates and Cox regression analyses were used to calculate 5-year percentages of growth to melanoma and HR. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3129
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http://dx.doi.org/10.1136/bjophthalmol-2018-312967DOI Listing
December 2018
3 Reads

Scleritis-associated vortex vein varix masquerading as choroidal melanoma.

Can J Ophthalmol 2018 Dec 2;53(6):e260-e262. Epub 2018 Apr 2.

Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, N.C.

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http://dx.doi.org/10.1016/j.jcjo.2018.02.002DOI Listing
December 2018
2 Reads

[Unilateral multifocal uveal melanoma (a clinical and genetic study)].

Vestn Oftalmol 2018;134(5):78-85

Institute of General Pathology and Pathophysiology, 8 Baltiiskaya St., Moscow, Russian Federation, 125315.

The study presents clinical and genetic analysis of a case of unilateral multifocal uveal choroidal melanoma in a patient of 67 years. Results of ophthalmoscopy, echography, fluorescent angiography, optical coherence tomography are described. Molecular genetic testing of peripheral blood samples was performed, including detection of the occurrences of CC genotype in C3435T polymorphism of the gene ABCB1/MDR1 associated with unfavorable vital prognosis. Read More

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http://dx.doi.org/10.17116/oftalma201813405178DOI Listing
January 2018
15 Reads

[Morphogenesis of choroidal melanomas in OCT imaging].

Vestn Oftalmol 2018;134(5. Vyp. 2):186-194

S.P. Botkin Moscow City Clinical Hospital, Branch No. 1, Ophtalmooncology department, 7 Mamonovskiy Lane, Moscow, Russian Federation, 123001.

When planning conservation therapy for choroidal melanoma (CM), evaluation of its size and stage is done using various methods of visualization, among which is optical coherence tomography (OCT). A recently introduced modification of OCT - Enhanced Depth Imaging (EDI) allows observation of deep choroid and sclera.

Purpose: To specify clinicomorphologic correlations between OCT signs related to CM and its pathomorphological state as described in literature. Read More

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http://dx.doi.org/10.17116/oftalma2018134051186DOI Listing
January 2018
12 Reads

[Ultrasound diagnosis and differential diagnosis of medium and small choroidal melanomas].

Zhonghua Yan Ke Za Zhi 2018 Nov;54(11):843-848

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab., Beijing Key Lab. of Intraocular Tumor Diagnosis and Treatment, Beijing 100730, China.

To analyze the ultrasound diagnosis and differential diagnosis of medium and small choroidal melanomas. It was a retrospective case series study. Thirty-six cases (36 eyes) with medium or small choroidal melanoma were collected between January 2016 and January 2017 in Beijing Tongren Hospital, including 16 males and 20 females aged (50±12) years old. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2018.11.009DOI Listing
November 2018
12 Reads

Clinical Features, Metastasis, and Survival in Patients Younger Than 21 Years With Posterior Uveal Melanoma.

JAMA Ophthalmol 2019 Jan;137(1):75-81

Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, Ohio.

Importance: Given the rarity of posterior uveal melanoma in patients younger than 21 years, reporting clinical experience in this area has relevance.

Objective: To describe the baseline clinical features, treatment, and clinical course of a group of patients younger than 21 years who have primary posterior uveal melanoma.

Design, Setting, And Participants: This retrospective descriptive case series of patients younger than 21 years who have a primary choroidal or ciliochoroidal melanoma was conducted at a single-center subspecialty referral practice. Read More

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https://jamanetwork.com/journals/jamaophthalmology/fullartic
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https://jamanetwork.com/collections/5798/intraocular-tumors
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https://jamanetwork.com/journals/jamaophthalmology/fullartic
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http://dx.doi.org/10.1001/jamaophthalmol.2018.5132DOI Listing
January 2019
12 Reads

Subretinal Fluid Optical Density and Spectral-Domain Optical Coherence Tomography Characteristics for the Diagnosis of Circumscribed Choroidal Hemangioma.

Ophthalmologica 2019 5;241(4):195-201. Epub 2018 Nov 5.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: To investigate spectral domain-optical coherence tomography (SD-OCT) features of untreated circumscribed choroidal hemangioma (CCH), and the optical density (OD) of the associated subretinal fluid (SRF).

Procedures: This international retrospective multicenter study conducted at 5 tertiary retina referral centers included 34 patients with symptomatic CCH imaged on SD-OCT. CCH surface, size, and overlying retinal changes and OD ratio (ODR) were evaluated. Read More

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https://www.karger.com/Article/FullText/492948
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http://dx.doi.org/10.1159/000492948DOI Listing
November 2018
12 Reads

Regression rate of choroidal melanoma following iodine-125 brachytherapy is not associated with metastatic spread.

Melanoma Res 2018 Oct 31. Epub 2018 Oct 31.

Centre universitaire d'ophtalmologie (CUO).

Nearly half of choroidal melanomas progress to the metastatic stage at 15 years. The purpose of our study was to evaluate the prognostic value of tumour-height regression rate in medium-sized choroidal melanomas treated with iodine-125 brachytherapy. A retrospective cohort study was performed on 128 patients with medium-sized choroidal melanoma who were treated with iodine-125 brachytherapy. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000540DOI Listing
October 2018

Sympathetic ophthalmia associated with untreated choroidal melanoma.

Can J Ophthalmol 2018 Oct 3;53(5):e173-e176. Epub 2018 Feb 3.

John Hunter Hospital, Newcastle, Australia.

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http://dx.doi.org/10.1016/j.jcjo.2017.11.013DOI Listing
October 2018

Uveal melanoma survival rates after single dose stereotactic radiosurgery.

Neoplasma 2018 Nov 4;65(6):965-971. Epub 2018 Sep 4.

Department of Ophthalmology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

This paper presents the long-term results of single dose stereotactic radiosurgery for intraocular uveal malignant melanoma, and summarizes the results of the retrospective study in 170 Slovak patients. A group of uveal melanoma patients (149 choroidal melanoma, 21 ciliary body melanoma) from 20 to 92 years of age with 59 year median were treated in 2001-2016. There were 81males (47. Read More

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http://dx.doi.org/10.4149/neo_2018_171209N808DOI Listing
November 2018
2 Reads

Metastatic choroidal melanoma to the contralateral eye: a rare case.

Arq Bras Oftalmol 2018 Nov./Dec.;81(6):517-519. Epub 2018 Oct 11.

Intervention Radiology Service, Radiology Department, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Uveal melanoma is the most common adult primary intraocular cancer. Although liver metastasis is common to the natural history of the disease, metastasis to the fellow eye is extremely rare. Here we report the case of a 59-year-old man with choroidal melanoma in his right eye who underwent enucleation at a different center. Read More

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http://dx.doi.org/10.5935/0004-2749.20180099DOI Listing
October 2018
2 Reads

20-year assessment of metastatic latency and subsequent time to death after proton therapy for uveal melanomas.

Melanoma Res 2018 Oct 12. Epub 2018 Oct 12.

Department of Ophthalmology, Croix-Rousse University Hospital.

The aim of this study was to evaluate metastatic latency and survival after the occurrence of metastases in patients with choroidal/ciliary body melanoma treated with proton therapy. This was a retrospective cohort study. All consecutive patients with choroidal/ciliary body melanoma treated with proton therapy between 1991 and 2010 were included. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000519DOI Listing
October 2018

Conjunctival Dehiscence and Scleral Necrosis following Iodine-125 Plaque Brachytherapy for Uveal Melanoma: A Report of 3 Cases.

Ocul Oncol Pathol 2018 Sep 13;4(5):291-296. Epub 2018 Feb 13.

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA.

Background/aims: Plaque brachytherapy is currently the most common treatment for uveal melanoma and has many known potential complications. Here we present 3 cases of early conjunctival and scleral necrosis following iodine-125 plaque.

Methods: This study was conducted as a retrospective case series. Read More

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https://www.karger.com/Article/FullText/481858
Publisher Site
http://dx.doi.org/10.1159/000481858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167656PMC
September 2018
10 Reads