793 results match your criteria Meigs Syndrome


Meigs syndrome.

Klin Onkol 2022 ;35(3):232-234

Background: Meigs syndrome is defined by the presence of a benign ovarian tumor, ascites, and pleural effusion (predominantly on the right side). A characteristic sign of Meigs syndrome is the complete disappearance of exudate after surgical resection of the ovarian tumor.

Case Report: We present a case report of a 58-year-old patient admitted for an advanced ovarian tumor with pleural effusion, ascites, and tumor marker elevation typical for ovarian cancer. Read More

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Large uterine leiomyoma presenting as pseudo-Meigs' syndrome with an elevated ca125: a case report and literature review.

J Surg Case Rep 2022 Jun 7;2022(6):rjac253. Epub 2022 Jun 7.

Department of Surgery, University of Texas Health Science Center, UT Health East Texas, Tyler, TX, USA.

Ascites, pelvic mass and elevated CA-125 in females carry a grim prognosis, likely an ovarian carcinoma. However, more benign etiologies such as Meigs' and pseudo-Meigs' syndrome must be considered. Pseudo-Meigs' syndrome presenting with an elevated CA-125 is rare and presents a diagnostic challenge. Read More

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The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature.

Sci Adv 2022 May 27;8(21):eabo5083. Epub 2022 May 27.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA.

The nonstructural protein 3 (NSP3) macrodomain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Mac1) removes adenosine diphosphate (ADP) ribosylation posttranslational modifications, playing a key role in the immune evasion capabilities of the virus responsible for the coronavirus disease 2019 pandemic. Here, we determined neutron and x-ray crystal structures of the SARS-CoV-2 NSP3 macrodomain using multiple crystal forms, temperatures, and pHs, across the apo and ADP-ribose-bound states. We characterize extensive solvation in the Mac1 active site and visualize how water networks reorganize upon binding of ADP-ribose and non-native ligands, inspiring strategies for displacing waters to increase the potency of Mac1 inhibitors. Read More

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Rare cause of ascites and pleural effusion: The first case report and literature review of pseudo-pseudo Meig's syndrome in Taiwan.

J Formos Med Assoc 2022 Apr 19. Epub 2022 Apr 19.

Division of Nephrology, Department of Internal Medicine, Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan. Electronic address:

Pseudo-pseudo Meigs' syndrome (PPMS) exhibits patients with ascites, pleural effusion, elevated CA-125, and diagnosed of systemic lupus erythematosus (SLE) eventually without evidence of ovarian or pelvic tumor. It's a rare diagnosis but it has a good response to treatment. We here present an 82-year-old female, who was found to have ascites, pleural effusion, and elevated CA-125. Read More

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Pseudo-pseudo Meig's syndrome presenting as an acute surgical abdomen: A rare entity and review of the literature.

J Obstet Gynaecol Res 2022 Apr 10. Epub 2022 Apr 10.

Department of Obstetrics and Gynecology, University of Health Sciences Umraniye Training and ResearchHospital, Istanbul, Turkey.

Aim: Pseudo-pseudo Meigs' syndrome is a rare entity of systemic lupus erythematosus, which is defined with the combination of pleural effusion, elevated serum CA-125 levels, and ascites. It has similar clinical aspects with gynecological malignancies which may lead gynecologists to perform unnecessary surgeries and lab workouts. This review seeks to point out the importance of diagnosing pseudo-pseudo Meig's syndrome (PPMS) and endeavors to inform gynecologists about the differential diagnoses. Read More

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A challenging case of pseudo Meigs syndrome: A case report.

J Pak Med Assoc 2022 Mar;72(3):547-549

Department of Gynaecology, and Obstetrics, Shalamar Hospital, Lahore, Pakistan.

Meigs Syndrome is a rare condition characterised by Ovarian fibroma, ascites and pleural effusion. Pseudo Meigs is called so because it mimics Meigs but occurs with tumours other than fibromas. The objective of this case report is to shed light on the diverse presentations of Ovarian carcinomas. Read More

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Demons syndrome with pericardial effusion followed by intensive care unit-acquired weakness: A case report and literature review.

SAGE Open Med Case Rep 2022 13;10:2050313X211069315. Epub 2022 Jan 13.

Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan.

Demons syndrome is defined by hydrothorax and ascites associated with a benign genital tumor that resolves after resection of the tumor. However, Demons syndrome with pericardial effusion has never been reported. Intensive care unit-acquired weakness is a neurological sequela to sepsis/systemic inflammatory response syndrome, or multi-organ failure. Read More

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January 2022

[A Case of Pseudo-Meigs' Syndrome Caused by Ovarian Metastasis from Colon Cancer].

Gan To Kagaku Ryoho 2021 Dec;48(13):2142-2144

Dept. of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine.

This case pertains to a female patient in her 60s who was diagnosed with carcinoma in the cecum with lung, ovarian, and peritoneal metastases. She complained of abdominal distension and poor feeding because her ascites and ovarian metastasis worsened 18 months after chemotherapy initiation. Repeated cytologic examination of the ascitic fluid revealed no malignant cells. Read More

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December 2021

Meigs Syndrome Caused by Ovarian Granulosa Cell Tumor: A Case Report.

J Pediatr Adolesc Gynecol 2022 Jun 13;35(3):407-409. Epub 2022 Jan 13.

Department of Gynaecology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Gynecological Oncology Research and Engineering Center of Hunan Province, Changsha, Hunan, China. Electronic address:

Background: Ovarian granulosa cell tumor (GCT) is extremely rare in children and adolescents, especially along with Meigs syndrome (MS).

Case: We describe the case of a 12-year-old girl who was referred to our center for massive peritoneal effusions with evidence of a pelvic mass on ultrasonography and computed tomography. The patient was treated with laparoscopic surgery (fertility-sparing surgery) and postoperative chemotherapy. Read More

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Meigs' syndrome and adult-type granulosa cell tumor.

Taiwan J Obstet Gynecol 2021 Nov;60(6):1116-1120

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Female Cancer Foundation, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address:

Objective: Adult-type granulosa cell tumors (GCT) are sex cord-stromal tumors and often accompanied with abdominal distention and hyperestrogenism-related symptoms. Adult-type GCT-presenting ascites and pleural effusion is extremely rare.

Case Report: A 56-year-old perimenopausal woman presented with abdominal distention and abnormal vaginal spotting. Read More

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November 2021

Understanding the Link Between Obesity and Severe COVID-19 Outcomes: Causal Mediation by Systemic Inflammatory Response.

J Clin Endocrinol Metab 2022 01;107(2):e698-e707

Division of Cardiology, Columbia University, New York, NY 10027, USA.

Background: Obesity is an established risk factor for severe COVID-19 outcomes. The mechanistic underpinnings of this association are not well-understood.

Objective: To evaluate the mediating role of systemic inflammation in obesity-associated COVID-19 outcomes. Read More

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January 2022

Giant Ovarian Thecoma Associated with Meigs Syndrome: A Striking Case.

Chirurgia (Bucur) 2021 Aug;116(eCollection):1-5

Meigs syndrome consists of the presence of a benign ovarian tumor, ascites and pleural effusion, and the latter two subdued after surgical excision of the ovarian tumor. Elevated Ca-125 in this context is confusing and is reported only in a handful of cases. A rare but striking case with the above features is presented herein. Read More

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A 36 kg Giant Ovarian Fibroma with Meigs Syndrome: A Case Report and Literature Review of Extremely Giant Ovarian Tumor.

Case Rep Obstet Gynecol 2021 15;2021:1076855. Epub 2021 Aug 15.

Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, 54 Shogoinkawahara-cho, Sakyo-ku, Kyoto city, Kyoto, Japan 606-8507.

Ovarian tumors can get extremely giant to occupy the whole abdominal cavity. We report a case of 36 kg solid ovarian tumor, which was the largest ovarian solid tumor that have been ever reported. A 54-year-old woman presented to our hospital with a chief complaint of markedly distended abdominal wall. Read More

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Meigs syndrome with pleural effusion as initial manifestation: A case report.

World J Clin Cases 2021 Jul;9(21):5972-5979

Department of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.

Background: Meigs syndrome is a rare neoplastic disease characterized by the triad of benign solid ovarian tumor, ascites, and pleural effusion. In postmenopausal women with pleural effusions, ascites, elevated CA-125 level, and pelvic masses, the probability of disseminated disease is high. Nevertheless, the final diagnosis is based on its histopathologic features following surgical removal of a mass lesion. Read More

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Lupus-related protein-losing enteropathy associated with pseudo-pseudo Meigs' syndrome and successfully treated with hydroxychloroquine.

Rom J Intern Med 2022 Mar 17;60(1):85-89. Epub 2022 Mar 17.

Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi783-8505, Japan.

We herein report the first case of lupus-related protein-losing enteropathy associated with pseudo-pseudo Meigs' syndrome. Lupus-related protein-losing enteropathy and pseudo-pseudo Meigs' syndrome are extremely rare complications in patients with systemic lupus erythematosus, Both have a similar clinical course characterized by producing marked ascites, and respond to steroids in typical cases. However, in our case, steroid monotherapy was inadequate and the addition of hydroxychloroquine was effective for their treatment. Read More

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Pelvic mass, ascites, hydrothorax: a malignant or benign condition? Meigs syndrome with high levels of CA 125.

Prz Menopauzalny 2021 Jun 25;20(2):103-107. Epub 2021 May 25.

Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.

Introduction: Abdominal-pelvic mass, ascites and pleural effusion are suggestive of malignant metastatic ovarian cancer. This triad is also present in a rare benign condition called Meigs syndrome. Rarely this condition is associated with an increased CA 125 level. Read More

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Visceral Adiposity and Severe COVID-19 Disease: Application of an Artificial Intelligence Algorithm to Improve Clinical Risk Prediction.

Open Forum Infect Dis 2021 Jul 28;8(7):ofab275. Epub 2021 May 28.

Medical Practice Evaluation Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Background: Obesity has been linked to severe clinical outcomes among people who are hospitalized with coronavirus disease 2019 (COVID-19). We tested the hypothesis that visceral adipose tissue (VAT) is associated with severe outcomes in patients hospitalized with COVID-19, independent of body mass index (BMI).

Methods: We analyzed data from the Massachusetts General Hospital COVID-19 Data Registry, which included patients admitted with polymerase chain reaction-confirmed severe acute respiratory syndrome coronavirus 2 infection from March 11 to May 4, 2020. Read More

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Meigs' syndrome caused by granulosa cell tumor accompanied with intrathoracic lesions: A case report.

World J Clin Cases 2021 Jun;9(18):4734-4740

Department of Respiratory and Critical Care Medicine, Suining Central Hospital, Suining 629000, Sichuan Province, China.

Background: Meigs' syndrome is regarded as a benign ovarian tumor accompanied by pleural effusion and ascites, both of which resolve after removal of the tumor. Patients often seek treatment in the Department of Respiratory and Critical Care Medicine or other internal medicine departments due to symptoms caused by ascites or hydrothorax. Here, we report a rare case of Meigs' syndrome caused by granulosa cell tumor accompanied with intrathoracic lesions. Read More

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The Immunopathobiology of SARS-CoV-2 Infection.

FEMS Microbiol Rev 2021 11;45(6)

Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, NE 68198, USA.

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to coronavirus disease 2019 (COVID-19). Virus-specific immunity controls infection, transmission and disease severity. With respect to disease severity, a spectrum of clinical outcomes occur associated with age, genetics, comorbidities and immune responses in an infected person. Read More

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November 2021

Ovarian dysgerminoma with pseudo-Meigs syndrome: A case report.

Medicine (Baltimore) 2021 Jun;100(23):e26319

Forensic and Pathology Laboratory, Jiaxing University Medical College, Jiaxing, ZJ, China.

Rationale: Dysgerminoma is a rare malignant tumor of the ovary, more frequently occurring in young women. The main signs of pseudo-Meigs syndrome (PMS) are ascites and hydrothorax accompanying benign or malignant ovarian tumors (no fibroma or fibroma-like tumor).

Patient Concerns: A 19-year-old woman with fever and chest tightness for 2 days. Read More

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Ovarian metastasis from breast cancer mimicking a primary ovarian neoplasm: A case report.

Mol Clin Oncol 2021 Jul 17;15(1):135. Epub 2021 May 17.

Department of Obstetrics and Gynecology, Tokyo Women's Medical University, Shinjuku, Tokyo 162-8666, Japan.

Ovarian metastasis (OM) from breast cancer accounts for 3-38% of all ovarian neoplasms and is associated with various characteristic clinical presentations, such as pseudo-Meigs syndrome and Krukenberg tumor. Accurate diagnosis of OM may be challenging, as such lesions are frequently asymptomatic until they reach a large size. Occasionally, metastatic ovarian cancer is detected prior to the diagnosis of the primary tumor. Read More

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Pseudo-pseudo Meigs' syndrome (PPMS) in chronic lupus peritonitis: a case report with review of literature.

Mod Rheumatol Case Rep 2021 07 10;5(2):300-305. Epub 2021 May 10.

Department of General Medicine, All India Institute of Medical Sciences, Jodhpur, India.

Gastrointestinal involvement in systemic lupus erythematosus (SLE) usually occurs in the form of mesenteric vasculitis, protein-losing enteropathy, intestinal pseudo-obstruction, and pancreatitis. We describe a 23-year-old female, a known case of SLE presented with significant ascites and pleural effusion. Further evaluation showed elevated CA-125 levels without evidence of malignancy. Read More

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Pseudo-Meigs' Syndrome in Tunisian H Syndrome Female Patient: First Case Reported.

Appl Clin Genet 2021 15;14:235-239. Epub 2021 Apr 15.

Department of Gastroenterology, Charles Nicolle Hospital, Tunis, Tunisia.

H syndrome is an extremely rare autosomal recessive affection caused by biallelic mutations in the SLC29A3 gene encoding the human equilibrative nucleoside transporter hENT3. The hallmark signs are cutaneous consisting of hyperpigmentation and hypertrichosis patches. Besides, associated systemic manifestations are highly various reflecting phenotypic pleiotropism. Read More

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Incomplete pseudo-Meigs' syndrome caused by endometrial ovarian cyst: A case report.

Respir Med Case Rep 2021 22;33:101387. Epub 2021 Mar 22.

Department of Respiratory Internal Medicine, Fukui Prefectural Hospital, 2-8-1 Yotsui, Fukui-shi, Fukui-ken, 910-8526, Japan.

A 63-year-old female was admitted to our hospital with history of persistent dyspnea. Right pleural effusion and ovarian tumor were discovered, but here were no significant findings on thoracoscopy under local anesthesia. The pleural effusion was suspected to be secondary to Meigs' syndrome, and a diagnosis of endometriotic ovarian cyst was made. Read More

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Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.

Sci Adv 2021 04 14;7(16). Epub 2021 Apr 14.

National Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY 11973, USA.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate-ribosylation signaling. This enzyme is a promising antiviral target because catalytic mutations render viruses nonpathogenic. Here, we report a massive crystallographic screening and computational docking effort, identifying new chemical matter primarily targeting the active site of the macrodomain. Read More

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Is there any relationship between massive ascites and elevated CA-125 in systemic lupus erythematosus? Case report and review of the literature.

Mod Rheumatol Case Rep 2021 07 20;5(2):292-299. Epub 2021 Apr 20.

Research Institute. Fundación Universitaria de Ciencia de la Salud (FUCS), Bogotá, Colombia.

Systemic lupus erythematosus (SLE) is a chronic, multisystemic autoimmune disease of variable presentation. Massive ascites in the context of SLE is infrequent. Even so, it has been reported that ascites may be the first manifestation of SLE. Read More

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Meigs syndrome presenting with severely elevated CA-125 level.

BMJ Case Rep 2021 Mar 2;14(3). Epub 2021 Mar 2.

Gynecology Oncology, Jersey Shore University Medical Center, Neptune City, New Jersey, USA.

A 64-year-old woman referred to Gynaecological Oncology secondary to the finding of pelvic mass and ascites. Imaging showed multiple pelvic masses, with the largest mass measuring 20 cm in diameter, as well as bilateral pleural effusions and abdominal ascites, suspicious for ovarian carcinoma. Laboratory findings included elevated cancer antigen 125 (CA-125) of 2124 units/mL. Read More

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