8,620 results match your criteria Megaloblastic Anemia

Letter to the editor regarding megaloblastic anemia with elevated vitamin B12.

Clin Biochem 2021 Jul 27. Epub 2021 Jul 27.

Hematology Research Laboratory, Department of Hematology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China. Electronic address:

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Long-term metformin therapy and vitamin B12 deficiency: An association to bear in mind.

World J Diabetes 2021 Jul;12(7):916-931

Diabetes Research Institute Federation (DRIF), Division of Endocrinology and Diabetes, CTO Alesini Hospital, Department of Systems Medicine, University of Rome Tor Vergata, Rome 00145, Italy.

To date, metformin remains the first-line oral glucose-lowering drug used for the treatment of type 2 diabetes thanks to its well-established long-term safety and efficacy profile. Indeed, metformin is the most widely used oral insulin-sensitizing agent, being prescribed to more than 100 million people worldwide, including patients with prediabetes, insulin resistance, and polycystic ovary syndrome. However, over the last decades several observational studies and meta-analyses have reported a significant association between long-term metformin therapy and an increased prevalence of vitamin B12 deficiency. Read More

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Deep Learning-Based Nuclear Lobe Count Method for Differential Count of Neutrophils.

Tohoku J Exp Med 2021 ;254(3):199-206

Faculty of Health Sciences, Hokkaido University.

Differentiating neutrophils based on the count of nuclear lobulation is useful for diagnosing various hematological disorders, including megaloblastic anemia, myelodysplastic syndrome, and sepsis. It has been reported that one-fifth of sepsis-infected patients worldwide died between 1990 and 2017. Notably, fewer nuclear-lobed and stab-formed neutrophils develop in the peripheral blood during sepsis. Read More

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January 2021

The beneficial role of vitamin B12 in injury induced by ischemia/reperfusion: Beyond scavenging superoxide?

Feng Li

J Exp Nephrol 2021 ;2(1):3-6

Department of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.

Vitamin B12 (B12) is required for cellular metabolism and DNA synthesis as a co-enzyme; it also possesses anti-reactive oxygen species (ROS) property as a superoxide scavenger. B12 deficiency has been implicated in multiple diseases such as megaloblastic anemia, and this disease can be effectively cured by supplementation of B12. Multiple studies suggest that B12 also benefits the conditions associated with excess ROS. Read More

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January 2021

Monogenic diabetes in Pakistani infants and children: challenges in a resource poor country.

J Pediatr Endocrinol Metab 2021 Jun 29. Epub 2021 Jun 29.

National Institute of Child Health, Karachi, Pakistan.

Objectives: To review the data of infants and children with suspected monogenic diabetes who underwent genetic testing.

Methods: Monogenic diabetes is a rare form of diabetes resulting from mutations in a single gene. It can be caused by dominant as well as recessive modes of inheritance. Read More

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Modulation of immune functions, inflammatory response, and cytokine production following long-term oral exposure to three food additives; thiabendazole, monosodium glutamate, and brilliant blue in rats.

Int Immunopharmacol 2021 Jun 26;98:107902. Epub 2021 Jun 26.

Department of Biochemistry, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt; Department of Biochemistry, College of Science, University of Jeddah, Jeddah, Saudi Arabia.

The food additives thiabendazole (TBZ), monosodium glutamate (MSG), and brilliant blue (BB) are commonly used in many daily-consumed food products worldwide. They are widely used in major agricultural and industrial applications. Yet, many of its toxicological aspects are still unclear, especially immune modulation. Read More

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A normal mean cell volume does not exclude a diagnosis of megaloblastic anemia.

Am J Hematol 2021 Jun 24. Epub 2021 Jun 24.

Centre for Haematology, St Mary's Hospital Campus of Imperial College Faculty of Medicine, St Mary's Hospital, London, UK.

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Genome-wide association study identifies five risk loci for pernicious anemia.

Nat Commun 2021 06 18;12(1):3761. Epub 2021 Jun 18.

Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.

Pernicious anemia is a rare condition characterized by vitamin B12 deficiency anemia due to lack of intrinsic factor, often caused by autoimmune gastritis. Patients with pernicious anemia have a higher incidence of other autoimmune disorders, such as type 1 diabetes, vitiligo, and autoimmune thyroid issues. Therefore, the disease has a clear autoimmune basis, although the genetic susceptibility factors have thus far remained poorly studied. Read More

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A retrospective cohort study on red blood cell morphology changes in pre-school age children under nitrous oxide anesthesia.

BMC Anesthesiol 2021 Jun 16;21(1):171. Epub 2021 Jun 16.

Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Megaloblastic anemia or bone marrow changes could occur after prolonged nitrous oxide inhalation via vitamin B inactivation related DNA synthesis impairment. Previous researches have studied hematological changes with nitrous oxide exposure, but only in adults or adolescents. Pre-school age children with active hematopoietic red bone marrow are more vulnerable to potential side effects of nitrous oxide and might experience growth impairment. Read More

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Determination of Folic Acid Using Biosensors-A Short Review of Recent Progress.

Sensors (Basel) 2021 May 12;21(10). Epub 2021 May 12.

Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy.

Folic acid (FA) is the synthetic surrogate of the essential B vitamin folate, alternatively named folacin, pteroylglutamic acid or vitamin B. FA is an electroactive compound that helps our body to create and keep our cells healthy: it acts as the main character in a variety of synthetic biological reactions such as the synthesis of purines, pyrimidine (thus being indirectly implied in DNA synthesis), fixing and methylation of DNA. Therefore, physiological folate deficiency may be responsible for severe degenerative conditions, including neural tube defects in developing embryos and megaloblastic anaemia at any age. Read More

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Subacute combined degeneration of the spinal cord concurrent with acute pulmonary embolism: a case report.

J Int Med Res 2021 May;49(5):3000605211016815

Department of Neurology and Neuroscience Centre, The First Hospital of Jilin University, Changchun, Jilin Province, China.

A 58-year-old male vegetarian presented with progressive numbness and weakness in the lower extremities. Laboratory examinations showed reduced vitamin B12 level with megaloblastic anaemia. Spinal magnetic resonance imaging (MRI) revealed hyperintensity within the posterior and lateral columns on T2-weighted imaging. Read More

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A 17-Month-old Boy With Pancytopenia Caused by a Rare Genetic Defect of Vitamin B12 Malabsorption.

J Pediatr Hematol Oncol 2021 May 31. Epub 2021 May 31.

Departments of Pediatrics Pathology Pediatrics and Prevention Genetics LLC Pediatric Hematology-Oncology Pediatric Intensive Care Unit, Marshfield Children's Hospital, Marshfield Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI.

Imerslund-Gräsbeck syndrome is an autosomal recessive disorder of vitamin B12 malabsorption presenting with megaloblastic anemia and mild proteinuria in childhood. The disorder is caused by biallelic pathogenic variants in the CUBN or AMN genes, which encode proteins involved in B12 absorption. We present the case of a 17-month-old boy with failure to thrive, pancytopenia, and fevers. Read More

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Hemorrhagic manifestation in different etiologies of pancytopenia: A prospective, cross-sectional study.

J Family Med Prim Care 2021 Feb 27;10(2):804-808. Epub 2021 Feb 27.

Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Mangalagiri, Andhra Pradesh, India.

Background: Pancytopenia is a triage of anemia, leukopenia, and thrombocytopenia. The etiology causing pancytopenia varies depending upon factors such as age, sex, occupation, and geographical distribution. Unfortunately, the major treatises of hematology have not given emphasis on the hemorrhagic manifestation of different etiologies causing pancytopenia. Read More

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February 2021

Comparative study of IgG binding to megakaryocytes in immune and myelodysplastic thrombocytopenic patients.

Ann Hematol 2021 Jul 13;100(7):1701-1709. Epub 2021 May 13.

Clinical Pathology Department, Faculty of Medicine, Minia University, Cornish Al-Nile Road, PO: 61519, Minia, Egypt.

Immune thrombocytopenia (ITP) is a disorder in which autoantibodies are responsible for destruction and decreased production of platelets. In the meantime, thrombocytopenia is frequent in patients with myelodysplastic syndromes (MDS) and immune clearance of megakaryocytes could be a reason. The aim of the present study is to evaluate and compare IgG binding to megakaryocytes in bone marrow of ITP and MDS patients to determine megakaryocytes targeting by autoantibodies in vivo as a mechanism of platelet underproduction in these disorders. Read More

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Anaemic retinopathy in megaloblastic anaemia.

Nepal J Ophthalmol 2020 Jul;12(24):313-316

Alluri Seetharamaraju Academy of Medical Sciences and Hospital, Eluru, West Godavari district, Andhra Pradesh, India.

Introduction: Anaemias are the commonest haematological disorders which cause ocular manifestations. With the progression of disease, retinal haemorrhages, dilated and tortuous veins, cotton wool spots may occur in the ocular fundus.

Case: An 18-year-old female patient presented to our out patient department with the sudden, painless, non-progressive blurring of vision in both eyes (best-corrected visual acuity in the right eye is 6/60, and left eye is 6/36) for two days. Read More

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Pernicious anaemia: cause of recurrent cerebral venous thrombosis.

BMJ Case Rep 2021 May 10;14(5). Epub 2021 May 10.

Baroda Medical College, Vadodara, Gujarat, India.

This case of recurrent cerebral venous thrombosis (CVT) highlights hyperhomocysteinemia in pernicious anemia due to vitamin B deficiency. No other risk factors such as trauma, infections, coagulation disorders or autoimmune diseases were present. The patient was cured with vitamin B and anticoagulation therapy. Read More

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Surviving Extreme Anaemia.

Eur J Case Rep Intern Med 2021 5;8(3):002357. Epub 2021 Mar 5.

Internal Medicine Department, Centro Hospitalar e Universitário São João, Porto, Portugal.

Before the development of transfusion medicine, severe anaemia was an important cause of morbidity and mortality. The discovery of haematopoietic mechanisms and essential nutrients made it possible to easily treat and prevent this condition. Nevertheless, it is often fatal in patients presenting with extreme anaemia (haemoglobin levels <2 g/dl). Read More

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Use of hyperbaric oxygenation as an adjunctive treatment for severe pernicious anaemia in a bloodless medicine patient.

BMJ Case Rep 2021 Apr 12;14(4). Epub 2021 Apr 12.

Bloodless Medicine and Surgery Program, MedStar Georgetown University Hospital, Washington, DC, USA.

Severe anaemia in patients who cannot receive blood transfusion is an indication for the use of hyperbaric oxygen therapy (HBO). Most reports of the use of HBO for anaemia involve patients with acute blood loss. This report details a case of HBO used for a patient with severe pernicious anaemia. Read More

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Case Report: Genetic and Clinical Features of Maternal Uniparental Isodisomy-Induced Thiamine-Responsive Megaloblastic Anemia Syndrome.

Front Pediatr 2021 19;9:630329. Epub 2021 Mar 19.

Caihong Hospital, Xianyang, China.

Thiamine-responsive megaloblastic anemia syndrome (TRMA) is a rare autosomal recessive hereditary disease due to mutations in . Some cases show familial inheritance. A female patient (from a gravida 1, para 1 mother) of 3. Read More

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Rapid Development of Pernicious Anemia Unmasking Underlying Gastric Adenocarcinoma.

Cureus 2021 Mar 1;13(3):e13630. Epub 2021 Mar 1.

Hematology/Oncology, Mercy Catholic Medical Center, Darby, USA.

Gastric cancer is one of the most common malignancies, often detected at later stages as patients remain asymptomatic until later stages. Pernicious anemia (PA), a well-known cause of vitamin B12 deficiency, is a classic risk factor for gastric cancer. Patients with PA usually present with megaloblastic anemia and peripheral neuropathy; however, they can also present with nonspecific symptoms. Read More

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[Extra hospital use of nitrous oxide for recreational purposes].

Rev Prat 2020 Dec;70(10):1143-1149

Service des urgences du CUB, hôpital Erasme, Bruxelles, Belgique.

Extra hospital use of nitrous oxide. FOR RECREATIONAL PURPOSESThe problematic recreational consumption of nitrous oxide is increasing in the adolescent population and its harms are little publicized and / or trivialized. This therefore represents a public health issue. Read More

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December 2020

Cutaneous hyperpigmentation and megaloblastic anemia as manifestations of gastric syphilis.

Int J Dermatol 2021 Mar 14. Epub 2021 Mar 14.

Departamento de Dermatologia e Radioterapia, FMB-UNESP, Botucatu, Brazil.

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Sub-internal limiting membrane haemorrhage following pancytopenia in megaloblastic anemia.

Clin Exp Optom 2021 Jul 1;104(5):653-655. Epub 2021 Mar 1.

Department of Ophthalmology, Lady Hardinge Medical College and Associated SSKH and KSC Hospital, University of Delhi, New Delhi, India.

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Long-term outcome of a patient with Transcobalamin deficiency caused by the homozygous c.1115_1116delCA mutation in TCN2 gene: a case report.

Ital J Pediatr 2021 Mar 8;47(1):54. Epub 2021 Mar 8.

Department of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.

Background: Transcobalamin deficiency is a rare autosomal recessive inborn error of cobalamin transport (prevalence: < 1/1000000) which clinically manifests in early infancy.

Case Presentation: We describe the case of a 31 years old woman who at the age of 30 days presented with the classical clinical and laboratory signs of an inborn error of vitamin B metabolism. Family history revealed a sister who died at the age of 3 months with a similar clinical syndrome and with pancytopenia. Read More

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The Effects of Genetic Mutations and Drugs on the Activity of the Thiamine Transporter, SLC19A2.

AAPS J 2021 03 1;23(2):35. Epub 2021 Mar 1.

Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, California, 94158, USA.

A rare cause of megaloblastic anemia (MA) is thiamine-responsive megaloblastic anemia (TRMA), a genetic disorder caused by mutations in SLC19A2 (encoding THTR1), a thiamine transporter. The study objectives were to (1) functionally characterize selected TRMA-associated SLC19A2 variants and (2) determine whether current prescription drugs associated with drug-induced MA (DIMA) may act via inhibition of SLC19A2. Functional characterization of selected SLC19A2 variants was performed by confocal microscopy and isotopic uptake studies of [3H]-thiamine in HEK293 cells. Read More

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Vitamine B12 deficiency in children: a diagnostic challenge.

Acta Gastroenterol Belg 2021 Jan-Mar;84(1):121-124

Department of Paediatric Gastroenterology, University Hospital Ghent, Corneel Heymanslaan 10, 9000 Ghent, Belgium.

Cobalamin or vitamin B12 (vitB12) is involved in DNA synthesis, haematopoiesis and myelinisation. Consequently, vitB12 deficiency causes various symptoms, such as megaloblastic anaemia, neurologic signs or pancytopenia. Despite possible severe symptoms, vitB12 deficiency can present asymptomatically. Read More

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A Case of Pseudothrombotic Microangiopathy Associated with Pernicious Anemia.

J Gen Intern Med 2021 06 23;36(6):1775-1777. Epub 2021 Feb 23.

John W. Deming Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA.

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Enteral Vitamin B12 Supplementation Is Effective for Improving Anemia in Patients Who Underwent Total Gastrectomy.

Oncology 2021 18;99(4):225-233. Epub 2021 Feb 18.

Department of Surgery, Kochi Medical School, Nankoku, Japan.

Background: This study aimed to investigate the efficacy of enteral supplementation of vitamin B12 for vitamin B12 deficiency in patients who underwent total gastrectomy for gastric cancer.

Methods: The study enrolled 133 patients who underwent total gastrectomy for gastric cancer at Kochi Medical School. Clinical data were obtained to investigate associations between vitamin B12 supplementation and vitamin B12 levels. Read More

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Potential contributors to low dose methotrexate toxicity in a patient with rheumatoid arthritis and pernicious anemia: case report.

BMC Rheumatol 2021 Feb 12;5(1). Epub 2021 Feb 12.

Department of Internal Medicine, WellStar Atlanta Medical Center, Atlanta, GA, USA.

Background: Low dose methotrexate toxicity rarely occurs, but may present with severe complications, such as pancytopenia, hepatotoxicity, mucositis, and pneumonitis. Known risk factors for methotrexate toxicity include dosing errors, metabolic syndrome, hypoalbuminemia, renal dysfunction, lack of folate supplementation, and the concomitant use of drugs that interfere with methotrexate metabolism. Vitamin B12 deficiency leads to megaloblastic anemia and may cause pancytopenia, but its role in methotrexate toxicity has not been described. Read More

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February 2021