8,705 results match your criteria Megaloblastic Anemia


Retinopathy of Megaloblastic Anaemia: Treatable and reversible.

J Pediatr 2022 Aug 6. Epub 2022 Aug 6.

Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India. 342005.

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Biogenic silver nanoparticles (AgNp-Bio) restore testosterone levels and increase TNF-α and IL-6 in Leydig cells infected with Toxoplasma gondii.

Exp Parasitol 2022 Aug 6:108343. Epub 2022 Aug 6.

Laboratory of Immunoparasitology, Department of Pathological Sciences, Universidade Estadual de Londrina, Londrina, PR, Brazil. Electronic address:

Toxoplasma gondii, a protozoan parasite, is responsible for toxoplasmosis. The available therapy for patients with toxoplasmosis involves a combination of pyrimethamine and sulfadiazine, which have several adverse effects, including bone marrow suppression, megaloblastic anemia, leukopenia, and granulocytopenia. The development of therapeutic alternatives is essential for the management of toxoplasmosis, emphasizing the recent advances in nanomedicine. Read More

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An Unusual Presentation of Vitamin B12 Deficiency Associated With Massive Splenomegaly, Hemolytic Anemia, and Pancytopenia: A Case Report.

Cureus 2022 Jun 18;14(6):e26058. Epub 2022 Jun 18.

Internal Medicine, Hamad General Hospital, Doha, QAT.

Deficiency of vitamin B12 usually presents with symptoms of anaemia or neurological dysfunction. We report a case of a young lady who was found to be vitamin B12 deficient with massive splenomegaly, haemolytic anaemia, and pancytopenia. She was thoroughly investigated for other causes of similar presentation. Read More

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[Vitamin B12 deficiency in an infant child of a mother with pernicious anemia].

Andes Pediatr 2022 Jun;93(3):410-415

Departamento de Pediatría, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.

Introduction: In infants, vitamin B12 deficiency is mainly due to nutritional deficiencies related to maternal deficit. Most cases of maternal deficiencies are associated with vegetarian diets. Pernicious anemia is an au toimmune disease that affects the absorption of this vitamin. Read More

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Coexistence of Primary Sjögren's Syndrome and Autoimmune Gastritis With Pernicious Anemia and Subacute Combined Degeneration of the Spinal Cord: Case Report and Literature Review.

Front Immunol 2022 23;13:908528. Epub 2022 Jun 23.

Department of Gastroenterology, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: Autoimmune gastritis (AIG) and Primary Sjögren's syndrome (pSS) are both autoimmune diseases with low prevalence in China. Subacute combined degeneration (SCD) of the spinal cord is the most common neurological manifestation of vitamin B12 deficiency. Until now, a patient with pSS and complications of AIG including SCD has not been reported. Read More

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Diabetes Out-of-the-Box: Diabetes Mellitus and Impairment in Hearing and Vision.

Curr Diab Rep 2022 Sep 5;22(9):423-432. Epub 2022 Jul 5.

Pediatric Endocrine and Diabetes Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.

Purposeof Review: This review aims to provide an update on the etiologies of diabetes that are due to genetic disorders and that co-occur with impaired hearing or vision and to compare them. The potential mechanisms, including novel treatments, will be detailed.

Recent Findings: Wolfram syndrome, Kearns-Sayre syndrome, thiamine-responsive megaloblastic anemia, and maternally inherited diabetes and deafness are genetic disorders characterized by diabetes, impaired hearing, and vision. Read More

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September 2022

A case report: subacute combined degeneration of the spinal cord and pernicious anemia caused by autoimmune gastritis.

Medicine (Baltimore) 2022 Jul 1;101(26):e29226. Epub 2022 Jul 1.

From the Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Pudong New District, Shanghai, China.

Introduction: Autoimmune gastritis causing both subacute combined degeneration of the spinal cord and pernicious anemia is rare in clinical practice. Here, we report a case of subacute combined degeneration of the spinal cord and pernicious anemia resulting from vitamin B12 deficiency due to autoimmune gastritis.

Patient Concerns: A 66-year-old woman presented with a 2-month history of numbness in her extremities. Read More

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An infantile case of hereditary folate malabsorption with sudden development of pulmonary hemorrhage: a case report.

J Med Case Rep 2022 Jun 30;16(1):268. Epub 2022 Jun 30.

Department of Pediatrics, Asahikawa Medical University, 2-1-1-1, Midorigaoka-Higashi, Asahikawa, Hokkaido, 078-8510, Japan.

Background: Hereditary folate malabsorption-a rare disorder caused by impairment of the folate transporter-can develop into severe folate deficiency manifesting as megaloblastic anemia and occasionally thrombocytopenia. Reportedly, megaloblastic anemia can manifest with hemorrhagic episodes, possibly due to ineffective platelet production and platelet dysfunction. However, life-threatening hemorrhage events in hereditary folate malabsorption have not been well investigated. Read More

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Folates in various African foods: Contents, Food processing and matrix effects.

Int J Vitam Nutr Res 2022 Jun 29. Epub 2022 Jun 29.

Doctoral School of Sciences and Technology, Laboratory of Applied Biochemistry and Immunology (LABIA), University Joseph KI-ZERBO, Ouagadougou, Burkina Faso.

Poor folate status is implicated in a wide variety of health disorders including megaloblastic anaemia, neural tube defects, and cardiovascular diseases. Human diet remains the main provider par excellence. Despite several public-health options to overcome this micronutrient deficiency, dietary folate intakes of women of childbearing age and children are still below recommendations in many African countries. Read More

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Thromboembolic complications of recreational nitrous oxide (ab)use: a systematic review.

J Thromb Thrombolysis 2022 Jun 27. Epub 2022 Jun 27.

Department of Radiology, Radiologist, Thoracic Imaging, Jessa Hospital, Hasselt, Belgium.

The recreatinal use of nitrous oxide has become more common in recent years, especially in adolescents and young adults. It has been mainly associated with medical conditions like megaloblastic anemia and (myelo)neuropathy. We report on the thromboembolic complications, a less known side effect, associated with recreational inhalation of nitrous oxide. Read More

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Frequency and utility of bone marrow examination in relapsed/refractory immune thrombocytopenia.

J Thromb Haemost 2022 Jun 25. Epub 2022 Jun 25.

Division of Hematology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.

Background: The diagnosis of immune thrombocytopenia (ITP) is one of exclusion. Although guidelines recommend against routine bone marrow examination (BME) at time of ITP diagnosis, the role of BME in relapsed/refractory ITP is unclear.

Objectives: To examine the frequency and predictors of BME in relapsed/refractory ITP. Read More

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Aetiology of pancytopenia: Experience of a South African tertiary academic centre.

Afr J Lab Med 2022 31;11(1):1645. Epub 2022 May 31.

Division of Haematological Pathology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Background: Pancytopenia is a manifestation of numerous disease entities. The causes of pancytopenia differ with geographic region, socio-economic factors and HIV prevalence. Awareness of the common causes of pancytopenia may aid timely diagnosis. Read More

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Spectrum of Pancytopenia in Adults Attending a Clinical Hematology Department: A Four-Year Experience From a Tertiary Care Center of Western India.

Cureus 2022 May 12;14(5):e24933. Epub 2022 May 12.

Emergency Medicine, Dr. Sampurnanand Medical College, Jodhpur, IND.

Background Pancytopenia is a common hematological condition encountered in clinical practice. Because there is a wide variation in causes of pancytopenia even in different populations of the same geographical region, identifying the pattern of underlying etiologies is crucial for proper management. This study was conducted to evaluate the clinico-hematological profile and different etiologies of pancytopenia among adults presenting to a clinical hematology department at a tertiary care hospital of Western India. Read More

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Vitamin B12 and Plant-Predominant Diets.

Authors:
Nicole D White

Am J Lifestyle Med 2022 May-Jun;16(3):295-297. Epub 2022 May 4.

Creighton University, Omaha, NE, USA.

Vitamin B12 deficiencies are common in individuals consuming plant-predominant diets, including those who consume diary and/or eggs. Deficiencies can lead to megaloblastic anemia and peripheral neuropathy, among other multi-system manifestations. The prevalence, assessment and prevention of vitamin B12 deficiency in patients following plant-predominant diets will be discussed. Read More

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Whole-Exome Sequencing Revealed a Pathogenic Nonsense Variant in the SLC19A2 Gene in an Iranian Family with Thiamine-Responsive Megaloblastic Anemia.

Lab Med 2022 Jun 10. Epub 2022 Jun 10.

Cardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Objective: Solute carrier family 19 member 2 (SLC19A2, OMIM *603941) encodes thiamine human transporter 1 (THTR-1), which contributes to bringing thiamine (vitamin B1) into cells. Mutations in SLC19A2 lead to a rare recessive genetic disorder termed thiamine-responsive megaloblastic anemia (TRMA) syndrome.

Methods: An Iranian family with TRMA was investigated by whole-exome sequencing (WES) to determine the genetic cause(s) of the disease. Read More

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Parenteral vs Oral Vitamin B12 in Children With Nutritional Macrocytic Anemia: A Randomized Controlled Trial.

Indian Pediatr 2022 May 31. Epub 2022 May 31.

Department of Pediatrics, Pramukhswami Medical College, Bhaikaka University, Karamsad, Gujarat. Correspondence to: Dr Krutika Rahul Tandon, Professor and Head, Department of Pediatrics, Pramukhswami Medical College, Bhaikaka University, Karamsad 388 325, Dist. Anand (Gujarat).

Objective: Background: There is limited literature in children on efficacy of different routes of vitamin B12 administration for vitamin B12 deficiency macrocytic-megaloblastic anemia.

Objective: To compare parenteral with oral vitamin B12 therapy in children with macrocytic-megaloblastic anemia.

Study Design: Single-center, open-label randomized controlled trial. Read More

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Transporters in Drug Development: International Transporter Consortium Update on Emerging Transporters of Clinical Importance.

Clin Pharmacol Ther 2022 May 13. Epub 2022 May 13.

Department of Pharmaceutical Sciences, University of Toronto, Leslie Dan Faculty of Pharmacy, Toronto, Ontario, Canada.

During its fourth transporter workshop in 2021, the International Transporter Consortium (ITC) provided updates on emerging clinically relevant transporters for drug development. Previously highlighted and new transporters were considered based on up-to-date clinical evidence of their importance in drug-drug interactions and potential for altered drug efficacy and safety, including drug-nutrient interactions leading to nutrient deficiencies. For the first time, folate transport pathways (PCFT, RFC, and FRα) were examined in-depth as a potential mechanism of drug-induced folate deficiency and related toxicities (e. Read More

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Utility of reticulocyte indices in the diagnosis of pancytopenia.

J Family Med Prim Care 2022 Apr 18;11(4):1335-1340. Epub 2022 Mar 18.

Department of Pediatrics, NEIGRIHMS, Shillong, Meghalaya, India.

Introduction: Pancytopenia is a hematological condition in which there is a reduction in all three cell lines of blood. This study aims to evaluate the utility of reticulocyte indices such as reticulocyte % (retic %), immature reticulocyte fraction (IRF), and mean reticulocyte volume (MRV) in identifying the cause of pancytopenia.

Materials And Methods: Reticulocyte indices were measured by an automated coulter. Read More

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A novel TCN2 mutation with unusual clinical manifestations of hemolytic crisis and unexplained metabolic acidosis: expanding the genotype and phenotype of transcobalamin II deficiency.

BMC Pediatr 2022 04 29;22(1):233. Epub 2022 Apr 29.

Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama 6 Rd., Rajthewi, Bangkok, 10400, Thailand.

Background: Transcobalamin deficiency is a rare inborn metabolic disorder, characterized by pancytopenia, megaloblastic anemia, failure to thrive, diarrhea, and psychomotor retardation.

Case Presentation: We describe a patient who first presented at 3 months of age, with pancytopenia, hepatosplenomegaly, recurrent infection, metabolic acidosis, and acute hemolytic crisis. Extensive hematologic and immunologic investigations did not identify inherited bone marrow failure syndrome, acute leukemia or its related disorders. Read More

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Elevated IL-19 Serum Levels in Patients With Pernicious Anemia and Autoimmune Gastritis.

Front Immunol 2022 11;13:887256. Epub 2022 Apr 11.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Pernicious anemia (PA) is a megaloblastic anemia consisting of hematological, gastric and immunological alterations. The immunopathogenesis of PA is sustained by both autoantibodies (e.g. Read More

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Pernicious Anemia: The Hematological Presentation of a Multifaceted Disorder Caused by Cobalamin Deficiency.

Nutrients 2022 Apr 17;14(8). Epub 2022 Apr 17.

Medical-Surgical Department of Clinical Sciences and Translational Medicine, Sant'Andrea Hospital, University Sapienza, 00189 Rome, Italy.

Pernicious anemia is still a neglected disorder in many medical contexts and is underdiagnosed in many patients. Pernicious anemia is linked to but different from autoimmune gastritis. Pernicious anemia occurs in a later stage of autoimmune atrophic gastritis when gastric intrinsic factor deficiency and consequent vitamin B deficiency may occur. Read More

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Effects of vitamin B12 supplementation on pain relief in certain diseases - a literature review.

Acta Biochim Pol 2022 Apr;69(2):265-271

Faculty of Medicine, Centre for Innovative Research in Medical and Natural Sciences, University of Rzeszów, Rzeszów Poland.

Based on current scientific reports, vitamin B12 (cobalamin), used in the treatment of pernicious anemia, may be used as a pain reliever. It has been shown to be effective in the treatment of different sorts of pain, including diabetic neuropathic, musculoskeletal, abdominal, back and spine ones, but also pain in Alzheimer's disease and pain ailments resulting from the development of neoplasms. In addition, it helps regeneration of the sensory nerves and relieves pain in eye diseases, for example in dry eye syndrome. Read More

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Macrocytic Anaemia: Not Always a Straightforward Diagnosis.

Cureus 2022 Mar 14;14(3):e23152. Epub 2022 Mar 14.

Internal Medicine, Centro Hospitalar de Entre Douro e Vouga, Santa Maria da Feira, PRT.

Macrocytosis is defined as a mean corpuscular volume greater than 100 femtolitres (fL). There are several causes for macrocytic anaemia, and they can be divided into megaloblastic or non-megaloblastic anaemia. Vitamin B12 deficiency is one of the most common causes of megaloblastic anaemia. Read More

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Absolute Neutrophil Count in Cases of Pancytopenia.

J Assoc Physicians India 2022 Apr;70(4):11-12

Army Hospital Research & Referral, New Delhi.

Pancytopenia is a common cause of hematological consultation. Common underlying causes include vitamin deficiency (vitamin B12, folic acid), drugs (hydroxyurea, phenytoin, methotrexate), and bone marrow failure syndrome. Aplastic anemia is one of the rarest hematological diseases and presents as pancytopenia. Read More

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Comment "Asymptomatic small intestinal ulcerative lesions: Obesity and are likely to be risk factors".

World J Gastroenterol 2022 Mar;28(10):1085-1087

Department of Obstetrics and Gynecology, Taizhou Women and Children's Hospital of Wenzhou Medical University, Taizhou 318000, Zhejiang Province, China.

There are many causes of anemia. It is unreasonable to simply associate anemia with asymptomatic ulcers in the small intestine. Read More

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Lutetium-177 Dotatate-Induced Hemolytic Anemia and Myelodysplastic Syndrome.

Cureus 2022 Feb 19;14(2):e22392. Epub 2022 Feb 19.

Pediatrics, Woodhull Medical Center, New York, USA.

Lutetium-177 (Lu) dotatate is a type of peptide receptor radioligand therapy (PRRT) using radiolabeled somatostatin for patients with progressive somatostatin receptor-positive gastrointestinal neuroendocrine tumors. While cases of therapy-related myeloid neoplasms (t-MN) have been described as a consequence of Lu dotatate, there are no reports of hemolytic anemia associated with therapy. We present a case of a 68-year-old woman with metastatic low-grade neuroendocrine tumor who presented four weeks after the second dose of Lu dotatate with progressive fatigue and dyspnea. Read More

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February 2022

COVID-19 fear-induced anorexia nervosa and obsessive-compulsive disorder leading to fatal megaloblastic anemia: Lethal psychological complication of the pandemic.

J Family Med Prim Care 2022 Feb 16;11(2):799-801. Epub 2022 Feb 16.

Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India.

We report a young female having severe pallor and breathlessness on presentation, being diagnosed as a case of megaloblastic anemia, which was confirmed on bone marrow biopsy. On detailed history taking, she was revealed to have anorexia nervosa precipitated due to extreme fear of COVID-19 along with obsessive-compulsive disorder. Thus, a psychiatric disorder presenting due to simple phobia of COVID-19 can also have a fatal outcome in the young. Read More

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February 2022

Atypical presentation of thiamine-responsive megaloblastic anemia in a Chinese baby boy.

Int J Lab Hematol 2022 Aug 31;44(4):e175-e178. Epub 2022 Mar 31.

Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China.

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