962 results match your criteria Megacolon Toxic


Consensus on the prevention, diagnosis, and treatment of Clostridium difficile infection.

Rev Gastroenterol Mex 2019 Apr 12. Epub 2019 Apr 12.

Hospital Ángeles y Hospital Lomas, San Luis Potosí, S.L.P., México. Electronic address:

In recent decades, Clostridium difficile infection (CDI) has become a worldwide health problem. Mexico is no exception, and therefore the Asociación Mexicana de Gastroenterología brought together a multidisciplinary group (gastroenterologists, endoscopists, internists, infectious disease specialists, and microbiologists) to carry out the "Consensus on the prevention, diagnosis, and treatment of Clostridium difficile infection", establishing useful recommendations (in relation to the adult population) for the medical community. Said recommendations are presented herein. Read More

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http://dx.doi.org/10.1016/j.rgmx.2018.12.001DOI Listing
April 2019
1 Read

Combination of oral vancomycin and intra-colonic vancomycin: Successful treatment of complicated pseudomembranous colitis in a child patient.

SAGE Open Med Case Rep 2019 19;7:2050313X19838442. Epub 2019 Mar 19.

Clinic of Gastroenterology, Adana City Research and Education Hospital, University of Health Sciences, Adana, Turkey.

The infection-related disease varies from mild diarrhoea to pseudomembranouscolitis. Although infection is commonly considered to be a hospital-acquired infection, a significant number of cases are community acquired. Community-acquired infection can exhibit itself as ileus or toxic megacolon. Read More

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http://dx.doi.org/10.1177/2050313X19838442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425522PMC
March 2019
3 Reads

A comprehensive review and update on ulcerative colitis.

Dis Mon 2019 Mar 2. Epub 2019 Mar 2.

Division of Gastroenterology, American University of Beirut, Beirut, Lebanon; Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, M2, C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA.

Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disorder of the colon that causes continuous mucosal inflammation extending from the rectum to the more proximal colon, with variable extents. UC is characterized by a relapsing and remitting course. UC was first described by Samuel Wilks in 1859 and it is more common than Crohn's disease worldwide. Read More

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http://dx.doi.org/10.1016/j.disamonth.2019.02.004DOI Listing
March 2019
5 Reads

Clostridioides difficile-related toxic megacolon after Cryptococcus neoformans cellulitis: A complex of two rare infections in an immunocompromised host.

J Infect Chemother 2019 May 21;25(5):379-384. Epub 2019 Feb 21.

Department of Clinical Infectious Diseases, Aichi Medical University Hospital, Nagakute, Aichi, Japan; Department of Infection Control and Prevention, Aichi Medical University Hospital, Nagakute, Aichi, Japan. Electronic address:

A 76-year-old Japanese woman was admitted due to uncontrolled cellulitis of the right lower leg. She had deep vein thrombosis on the right limb. Moreover, she had a long history of rheumatoid arthritis treated with corticosteroids. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.12.003DOI Listing
May 2019
6 Reads

Community-acquired fulminant colitis caused by binary toxin-producing Clostridium difficile in Japan.

Clin J Gastroenterol 2019 Feb 14. Epub 2019 Feb 14.

Third Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan.

We report a case of community-acquired fulminant colitis caused by Clostridium difficile in Japan. A 46-year-old woman was diagnosed with severe infectious enterocolitis and was admitted at another hospital. The stool culture was positive for toxigenic C. Read More

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http://dx.doi.org/10.1007/s12328-019-00949-zDOI Listing
February 2019
2 Reads

Multilocus Variable-Number Tandem-Repeat Analysis of Clusters in Ribotype 027 Isolates and Lack of Association with Clinical Outcomes.

J Clin Microbiol 2019 Feb 13. Epub 2019 Feb 13.

Department of Microbiology and Infectious Disease, Université de Sherbrooke, Sherbrooke, Quebec, Canada

The epidemiology of infection (CDI) has drastically changed since the emergence of the epidemic strain BI/NAP1/027, also known as ribotype 027 (R027). However, the relationship between the infecting strain and clinical outcomes is still debated. We hypothesized that certain subpopulations of R027 isolates could be associated with unfavorable outcomes. Read More

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http://dx.doi.org/10.1128/JCM.01724-18DOI Listing
February 2019
1 Read

Hemolytic uremic syndrome: differential diagnosis with the onset of inflammatory bowel diseases.

Acta Biomed 2018 Dec 17;89(9-S):153-157. Epub 2018 Dec 17.

Pediatric Emergency Unit, University Hospital of Parma, Maternal and Infant Department, Parma, Italy.

Background: Shiga-toxin Escherichia coli productor (STEC) provokes frequently an important intestinal damage that may be considered in differential diagnosis with the onset of Inflammatory Bowel Disease (IBD). The aim of this work is to review in the current literature about Hemolytic Uremic Syndrome (HUS) and IBD symptoms at the onset, comparing the clinical presentation and symptoms, as the timing of diagnosis and of the correct treatment of both these conditions is a fundamental prognostic factor. A focus is made about the association between typical or atypical HUS and IBD and a possible renal involvement in patient with IBD (IgA-nephropathy). Read More

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http://dx.doi.org/10.23750/abm.v89i9-S.7911DOI Listing
December 2018
19 Reads

H, C and N resonance assignments and structure prediction of translation initiation factor 1 from Clostridium difficile.

Biomol NMR Assign 2019 04 28;13(1):91-95. Epub 2018 Oct 28.

Department of Chemistry, The University of Texas Rio Grande Valley, Edinburg, TX, USA.

Clostridium difficile is a gram-positive, toxin-producing, anaerobic bacterium whose virulence factors and mechanisms of pathogenesis require further investigation. C. difficile infections (CDI) result in the severe and potentially fatal gastrointestinal diseases pseudomembranous colitis and toxic megacolon following extensive broad spectrum antibiotic treatment. Read More

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http://link.springer.com/10.1007/s12104-018-9858-8
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http://dx.doi.org/10.1007/s12104-018-9858-8DOI Listing
April 2019
15 Reads

Diagnosis and Treatment of Invasive Aspergillus fumigatus Wound Infection Following Subtotal Colectomy for Perforated Toxic Megacolon in an Immunosuppressed Patient.

Wounds 2018 Oct;30(10):E102-E104

Department of Surgery, Swedish Medical Center, Seattle, WA.

Introduction: Aspergillus is a rare cause of surgical site infection most often seen in immunocompromised patients undergoing cardiac, transplant, ophthalmologic, or burn operations; an unusual case following a colon resection is presented here.

Case Report: The authors report a case of an invasive Aspergillus fumigatus infection following a subtotal colectomy for toxic megacolon. The patient was on antibiotics following the operation and chronic immunosuppression with steroids and infliximab. Read More

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October 2018
23 Reads

Imaging features of toxic megacolon.

BMJ Case Rep 2018 Sep 30;2018. Epub 2018 Sep 30.

Department of Diagnostic Imaging, Hospital Tuanku Ja'afar Seremban, Seremban, Malaysia.

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http://dx.doi.org/10.1136/bcr-2018-227121DOI Listing
September 2018
14 Reads

Evaluation of risk factors for a fulminant Clostridium difficile infection after cardiac surgery: a single-center, retrospective cohort study.

BMC Anesthesiol 2018 09 27;18(1):133. Epub 2018 Sep 27.

University Department for Cardiac Surgery, Heart Center Leipzig, Struempellstr. 39, 04289, Leipzig, Germany.

Background: Clostridium difficile (CD) is the most common pathogen causing nosocomial diarrhea. The clinical presentation ranges from mild diarrhea to severe complications, including pseudomembranous colitis, toxic megacolon, sepsis, and multi-organ failure. When the disease takes a fulminant course, death ensues rapidly in severe and complex cases. Read More

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http://dx.doi.org/10.1186/s12871-018-0597-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158878PMC
September 2018
18 Reads

Mouse Gamma Herpesvirus MHV-68 Induces Severe Gastrointestinal (GI) Dilatation in Interferon Gamma Receptor-Deficient Mice (IFNγR) That Is Blocked by Interleukin-10.

Viruses 2018 09 23;10(10). Epub 2018 Sep 23.

Department of Medicine, Divisions of Cardiovascular Medicine and Rheumatology, University of Florida, Gainesville, FL 32610-0277, USA.

Inflammatory bowel disease (IBD) and infection cause gastrointestinal (GI) distension and, in severe cases, toxic megacolon with risk of perforation and death. Herpesviruses have been linked to severe GI dilatation. MHV-68 is a model for human gamma herpesvirus infection inducing GI dilatation in interleukin-10 (IL-10)-deficient mice but is benign in wildtype mice. Read More

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http://dx.doi.org/10.3390/v10100518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213885PMC
September 2018
22 Reads

Atypical onset of total colonic Hirschsprung disease in a small female infant: A case report.

Medicine (Baltimore) 2018 Sep;97(38):e12315

University of Medicine and Pharmacy of Tirgu Mures, Tirgu Mures, Romania.

Rationale: Hirschsprung disease (HD) or colonic aganglionosis is a congenital disorder, which results from the abnormal migration of neuronal cells of the neural crest leading to a disorder of the enteric nervous system consisting in the absence of ganglion cells within the submucosal and myenteric plexus.

Patient Concerns: We report the case of a 7-month-old female infant admitted in our clinic for constipation and failure to thrive. At the age of 6 months, she was examined in our clinic for the same reasons, and we recommended symptomatic treatment without improvements. Read More

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http://dx.doi.org/10.1097/MD.0000000000012315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160117PMC
September 2018
16 Reads
5.723 Impact Factor

First reported case of afatinib-associated toxic megacolon.

Respirol Case Rep 2018 Oct 31;6(7):e00360. Epub 2018 Aug 31.

Department of Medicine Queen Mary Hospital Hong Kong China.

We report the first case of toxic megacolon associated with afatinib use, which is a potentially fatal complication, with risks of colonic perforation. In this case, the condition improved on stopping afatnib. Clinicians need to be alert of this rare but fatal adverse effect and to avoid anti-diarrhoeal agents, which can worsen toxic megacolon. Read More

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http://dx.doi.org/10.1002/rcr2.360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117793PMC
October 2018
14 Reads

Variable spectrum of disease and risk factors of peripartum Clostridium difficile infection: report of 14 cases from French hospitals and literature review.

Eur J Clin Microbiol Infect Dis 2018 Dec 3;37(12):2293-2299. Epub 2018 Sep 3.

Service de Biologie, Unité de Microbiologie, Centre Hospitalier de Versailles, Le Chesnay, France.

Our aim was to study Clostridium difficile infection (CDI) in peripartum women in France and compare them to cases published in the literature. We characterize these infections regarding clinico-biological features and specific risk factors in order to raise awareness for obstetricians and midwifes. Eight antepartum and six post-partum CDI cases were retrospectively studied in 6 French centers during the period between 2008 and 2013. Read More

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http://dx.doi.org/10.1007/s10096-018-3372-xDOI Listing
December 2018
26 Reads

colitis and zoonotic origins-a narrative review.

Gastroenterol Rep (Oxf) 2018 Aug 28;6(3):157-166. Epub 2018 Jun 28.

General Surgery Department, Liverpool Hospital, Elizabeth St, Liverpool, NSW, Australia.

is a major cause of hospital-associated diarrhoea, and in severe cases leads to pseudomembranous colitis and toxic megacolon. The frequency of infection (CDI) has increased in recent decades, with 453 000 cases identified in 2011 in the USA. This is related to antibiotic-selection pressure, disruption of normal host intestinal microbiota and emergence of antibiotic-resistant strains. Read More

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https://academic.oup.com/gastro/article/6/3/157/5046687
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http://dx.doi.org/10.1093/gastro/goy016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101521PMC
August 2018
27 Reads

Prevalence and Strain Characterization of in Representative Regions of Germany, Ghana, Tanzania and Indonesia - A Comparative Multi-Center Cross-Sectional Study.

Front Microbiol 2018 7;9:1843. Epub 2018 Aug 7.

Institute of Medical Microbiology, University Medical Center Göttingen Göttingen, Germany.

infections (CDI) are considered worldwide as emerging health threat. Uptake of spores may result in asymptomatic carrier status or lead to CDI that could range from mild diarrhea, eventually developing into pseudomembranous colitis up to a toxic megacolon that often results in high mortality. Most epidemiological studies to date have been performed in middle- and high income countries. Read More

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http://dx.doi.org/10.3389/fmicb.2018.01843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090210PMC
August 2018
13 Reads

Clostridium difficile, the Difficult "Kloster" Fuelled by Antibiotics.

Curr Microbiol 2018 Aug 6. Epub 2018 Aug 6.

Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, 141, Stockholm, Sweden.

Clostridium difficile is normally present in low numbers in a healthy adult gastro-intestinal tract (GIT). Drastic changes in the microbial population, e.g. Read More

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http://link.springer.com/10.1007/s00284-018-1543-8
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http://dx.doi.org/10.1007/s00284-018-1543-8DOI Listing
August 2018
34 Reads

In-hospital mortality for toxic megacolon.

Intern Emerg Med 2018 09 2;13(6):837-838. Epub 2018 Aug 2.

Clinica Medica I, Department of Internal Medicine, IRCCS San Matteo Hospital Foundation, University of Pavia, Pavia, 27100, Italy.

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http://dx.doi.org/10.1007/s11739-018-1919-6DOI Listing
September 2018
21 Reads

HSV1/2 Genital Infection in Mice Cause Reversible Delayed Gastrointestinal Transit: A Model for Enteric Myopathy.

Front Med (Lausanne) 2018 17;5:176. Epub 2018 Jul 17.

All India Institute of Medical Sciences, New Delhi, India.

In an interesting investigation by Khoury-Hanold et al. (1), genital infection of mice with herpes simplex virus 1 (HSV1) were reported to cause multiple pelvic organ involvement and obstruction. A small subset of mice succumbed after the first week of HSV1 infection. Read More

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http://dx.doi.org/10.3389/fmed.2018.00176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056620PMC
July 2018
18 Reads

Pulmonary Involvement in Crohn's Disease: A Rare Case Report.

Cureus 2018 May 30;10(5):e2710. Epub 2018 May 30.

Graduate, Pontifical Catholic University of Ecuador, Chagrin Falls, USA.

Crohn's disease (CD) is a granulomatous inflammatory disease that can involve any part of the gastrointestinal tract, from mouth to anus. In most cases, it remits and relapses in the terminal ileum, requiring treatment via steroid boluses. In rare cases, however, CD can involve the pulmonary system presenting as dyspnea on exertion and dry cough. Read More

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http://dx.doi.org/10.7759/cureus.2710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065616PMC
May 2018
17 Reads

Symptomatic pulmonary restriction secondary to diaphragmatic eventration and megacolon in adult.

BMJ Case Rep 2018 Jul 26;2018. Epub 2018 Jul 26.

General Surgery, NYU Langone Medical Center, Brooklyn, New York, USA.

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http://dx.doi.org/10.1136/bcr-2018-225778DOI Listing
July 2018
4 Reads

[Inflammatory bowel disease: cardinal signs and their diagnostics].

Dtsch Med Wochenschr 2018 Jul 4;113(13):937-944. Epub 2018 Jul 4.

Inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, often occur early in life. Therefore, they affect our patient's individual path of life, their ability to work and the quality of life tremendously, which calls for close and comprehensive medical care. This article features 5 cardinal signs and their diagnostics. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0612-3564
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http://dx.doi.org/10.1055/a-0612-3564DOI Listing
July 2018
14 Reads

Incidence, features, in-hospital outcomes and predictors of in-hospital mortality associated with toxic megacolon hospitalizations in the United States.

Intern Emerg Med 2018 Sep 12;13(6):881-887. Epub 2018 Jun 12.

Department of Internal Medicine, HCA GME Consortium's Internal Medicine Program, University of Central Florida College of Medicine, Gainesville, FL, USA.

Toxic megacolon (TM) is a potentially fatal condition characterized by non-obstructive colonic dilatation and systemic toxicity. It is most commonly caused by inflammatory bowel disease (IBD). Limited data for TM are available demonstrating incidence, in-hospital outcomes and predictors of mortality. Read More

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http://dx.doi.org/10.1007/s11739-018-1889-8DOI Listing
September 2018
14 Reads

Current updates in management of Clostridium difficile infection in cancer patients.

Curr Med Res Opin 2019 Mar 5;35(3):473-478. Epub 2018 Jul 5.

e Department of Hematology & Oncology , St. Luke's Hospital of Kansas City/University of Missouri , Kansas City , MO , USA.

Background: Clostridium difficile infection (CDI) is a significant health burden, now recognized as the leading cause of acquired diarrhea in patients receiving antibiotic therapy. Complications of infection with this pathogen include severe diarrhea, causing electrolyte imbalances, dehydration, hemodynamic instability, toxic megacolon, shock, and death. Hence it is extremely paramount to stay updated on management options for this infection, especially in cancer patients. Read More

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https://www.tandfonline.com/doi/full/10.1080/03007995.2018.1
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http://dx.doi.org/10.1080/03007995.2018.1487389DOI Listing
March 2019
16 Reads

infection and antibiotic-associated diarrhoea.

Clin Med (Lond) 2018 06;18(3):237-241

St Mary's Hospital Campus, Imperial College London, London, UK.

Antibiotic-associated diarrhoea is among the most common adverse events related to antibiotic use. Most cases are mild, but infection causes a spectrum of disease, ranging from occasional diarrhoea to colitis, toxic megacolon, and potentially death. Recent developments in our understanding of the biology of the gut microbiota have provided new insights into the pathogenesis of these conditions, and have revealed a role for manipulation of the gut microbiota as a novel therapeutic approach. Read More

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http://dx.doi.org/10.7861/clinmedicine.18-3-237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334067PMC
June 2018
16 Reads

Congenital diaphragmatic disease: An unusual presentation in adulthood. Case report.

Int J Surg Case Rep 2018 7;48:34-37. Epub 2018 May 7.

Department of Biomedical Sciences and Human Oncology, Unit of Endocrine, Digestive and Emergency Surgery, University Medical School "A. Moro'', Bari, Italy.

Introduction: Congenital diaphragmatic disease is a quite common condition that usually occurs in the neonatal period, and the diagnosis of congenital diaphragmatic disease in adulthood is rare.

Case Presentation: A 64-years-old Caucasian woman was admitted in emergency at our Department, due to a bowel obstruction and dyspnea. A CT-scan showed a diaphragmatic herniation in the left area, with malposition of dilated transverse and descending colon in the chest. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026686PMC
May 2018
16 Reads

Bis-Cyclic Guanidines as a Novel Class of Compounds Potent against Clostridium difficile.

ChemMedChem 2018 Jul 14;13(14):1414-1420. Epub 2018 Jun 14.

Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL, 33620, USA.

Clostridium difficile infection (CDI) symptoms range from diarrhea to severe toxic megacolon and even death. Due to its rapid acquisition of resistance, C. difficile is listed as an urgent antibiotic-resistant threat, and has surpassed methicillin-resistant Staphylococcus aureus (MRSA) as the most common hospital-acquired infection in the USA. Read More

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http://doi.wiley.com/10.1002/cmdc.201800240
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http://dx.doi.org/10.1002/cmdc.201800240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121702PMC
July 2018
16 Reads
2.970 Impact Factor

- From Colonization to Infection.

Front Microbiol 2018 10;9:646. Epub 2018 Apr 10.

Extracorporeal Immunomodulation Unit, Fraunhofer Institute for Cell Therapy and Immunology, Rostock, Germany.

is the most frequent cause of nosocomial antibiotic-associated diarrhea. The incidence of infection (CDI) has been rising worldwide with subsequent increases in morbidity, mortality, and health care costs. Asymptomatic colonization with is common and a high prevalence has been found in specific cohorts, e. Read More

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http://dx.doi.org/10.3389/fmicb.2018.00646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902504PMC
April 2018
21 Reads

Serum vancomycin concentrations after oral and intracolonic vancomycin administration in a patient with colonic discontinuity and severe infection.

Am J Health Syst Pharm 2018 May;75(9):e189-e193

Division of Infectious Diseases, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany

Purpose: A case of detectable systemic vancomycin levels after oral vancomycin administration but not after intracolonic administration in a patient with colonic discontinuity and severe infection (CDI) is reported.

Summary: A 63-year-old woman who had recently undergone pancreas-kidney transplantation developed severe CDI after 13 days of meropenem therapy for presumed urosepsis. Meropenem was stopped immediately, and treatment with oral vancomycin (250 mg every 6 hours) was started. Read More

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http://dx.doi.org/10.2146/ajhp170200DOI Listing
May 2018
13 Reads

Endoscopic Treatment of Ileal Pouch Sinus.

Authors:
Nan Lan Bo Shen

Inflamm Bowel Dis 2018 06;24(7):1510-1519

Interventional Inflammatory Bowel Disease (i-IBD) Unit, Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

Background And Aims: Pouch sinus is a serious complication in patients undergoing ileal pouch-anal anastomosis. The aim of this study was to verify the efficacy and safety of endoscopic needle knife sinusotomy (NKSi) in the management of pouch sinus.

Methods: All consecutive patients with a pouch sinus treated with NKSi from 2008 to 2016 were identified. Read More

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http://dx.doi.org/10.1093/ibd/izy029DOI Listing
June 2018
20 Reads

Shigellosis and toxic megacolon secondary to Shigella flexneri serotype 3a: The challenges of laboratory diagnosis.

Int J Infect Dis 2018 May 2;70:104-106. Epub 2018 Mar 2.

Division of Infection, Barts Health NHS Trust, London, United Kingdom.

We present a rare case of Shigella flexneri bacteraemia and toxic megacolon, and discuss the challenges of conventional laboratory techniques versus molecular PCR platforms in differentiating between Shigella species and Escherichia coli. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.02.020DOI Listing
May 2018
11 Reads
2.330 Impact Factor

Gastrointestinal Motility Problems in Critically Ill Patients.

Crit Care Nurs Clin North Am 2018 Mar 29;30(1):109-121. Epub 2017 Nov 29.

College of Health Sciences, School of Nursing, Walden University, 100 Washington Avenue South, Suite 900, Minneapolis, MN 55401, USA.

Gastrointestinal (GI) motility problems are common complications in critical care patients. GI problems contribute to an increased risk of morbidity and mortality. Toxic megacolon (TM) is a type of acquired megacolon categorized as a medical emergency and includes severe inflammation affecting all layers of the colon wall. Read More

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http://dx.doi.org/10.1016/j.cnc.2017.10.010DOI Listing
March 2018
17 Reads

Lauric Acid Is an Inhibitor of Growth and Reduces Inflammation in a Mouse Infection Model.

Front Microbiol 2017 17;8:2635. Epub 2018 Jan 17.

Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

is a Gram-positive, spore-forming anaerobic human gastrointestinal pathogen. infection (CDI) is a major health concern worldwide, with symptoms ranging from diarrhea to pseudomembranous colitis, toxic megacolon, sepsis, and death. CDI onset and progression are mostly caused by intestinal dysbiosis and exposure to spores. Read More

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http://dx.doi.org/10.3389/fmicb.2017.02635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776096PMC
January 2018
24 Reads

Beware of air.

BMJ Case Rep 2018 Jan 11;2018. Epub 2018 Jan 11.

Department of Intensive Care Unit, Gelderse Vallei Hospital, Ede, The Netherlands.

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http://dx.doi.org/10.1136/bcr-2017-223081DOI Listing
January 2018
20 Reads

Comparative genome and phenotypic analysis of three Clostridioides difficile strains isolated from a single patient provide insight into multiple infection of C. difficile.

BMC Genomics 2018 01 2;19(1). Epub 2018 Jan 2.

Department of Genomic and Applied Microbiology & Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August-University, Göttingen, Germany.

Background: Clostridioides difficile infections (CDI) have emerged over the past decade causing symptoms that range from mild, antibiotic-associated diarrhea (AAD) to life-threatening toxic megacolon. In this study, we describe a multiple and isochronal (mixed) CDI caused by the isolates DSM 27638, DSM 27639 and DSM 27640 that already initially showed different morphotypes on solid media.

Results: The three isolates belonging to the ribotypes (RT) 012 (DSM 27639) and 027 (DSM 27638 and DSM 27640) were phenotypically characterized and high quality closed genome sequences were generated. Read More

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https://bmcgenomics.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12864-017-4368-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749029PMC
January 2018
27 Reads

Adaptive Returns of Deficient Systemic Plasma Immunoglobulin G Levels as Rehabilitation Biomarker After Emergency Colectomy for Fulminant Ulcerative Colitis.

Clin Med Insights Gastroenterol 2017 13;10:1179552217746692. Epub 2017 Dec 13.

Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN, USA.

Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis (IPAA) is the standard surgical treatment for ulcerative colitis (UC). Emergency colectomies are performed for fulminant colitis (ie, toxic megacolon, profuse bleeding, perforation, or sepsis). The RPC and IPAA involve manipulation of the proximal ileum, which may influence the essential physiological function of gut-associated lymphoid tissues. Read More

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http://dx.doi.org/10.1177/1179552217746692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734426PMC
December 2017
35 Reads

Investigation of Clostridium difficile ribotypes in symptomatic patients of a German pediatric oncology center.

Eur J Pediatr 2018 Mar 22;177(3):403-408. Epub 2017 Dec 22.

Institute of Medical Microbiology and Hygiene, National Consultant Laboratory for Clostridium difficile, University of Saarland Medical Centre, Homburg, Germany.

In a German pediatric oncology unit, the attending physicians diagnosed 27 cases of Clostridium difficile-associated disease (CDI) from January 01, 2010 to October 31, 2013. This refers to a CDI incidence density of 2.0/1000 inpatient days. Read More

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http://link.springer.com/10.1007/s00431-017-3070-1
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http://dx.doi.org/10.1007/s00431-017-3070-1DOI Listing
March 2018
23 Reads

[German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS) position statement on endoscopic decompression in acute Ileus].

Z Gastroenterol 2017 Dec 6;55(12):1499-1508. Epub 2017 Dec 6.

Klinik und Poliklinik für Innere Medizin A, Universitätsklinikum Greifswald.

In patients with ileus with dilated intestine in imaging studies, endoscopic decompression appears a feasible option. However, its use is often uncritical and without scientific evidence. Before considering endoscopic intervention, CT-imaging should differentiate between mechanical obstruction and paralytic ileus/intestinal pseudo-obstruction. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-120351
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http://dx.doi.org/10.1055/s-0043-120351DOI Listing
December 2017
25 Reads

[Clostridium difficile Infection: Epidemiology, Clinical Presentation, Therapy and Prevention].

Zentralbl Chir 2018 Jun 30;143(3):241-249. Epub 2017 Nov 30.

Chirurgische Klinik, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Bochum, Deutschland.

Clostridium difficile infections (CDI) are common causes of diarrhoea in hospitalised medical and surgical patients. Clinical presentation ranges from mild diarrhoea to pseudomembraneous enterocolitis of the colon and sometimes the small intestines, with development of a toxic megacolon. Recurrent infections are common. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-119894
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http://dx.doi.org/10.1055/s-0043-119894DOI Listing
June 2018
13 Reads

Management of acute severe ulcerative colitis in children.

Semin Pediatr Surg 2017 Dec 5;26(6):367-372. Epub 2017 Oct 5.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Division of Pediatric Surgery, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania. Electronic address:

The incidence of pediatric-onset ulcerative colitis (UC) is rising. Children often present with a more severe disease phenotype as compared to adults with over a third requiring hospitalization for the management of acute severe ulcerative colitis (ASUC). Further, in pediatric patients presenting with inflammatory bowel disease (IBD) limited to the colon, a definitive diagnosis of UC vs. Read More

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http://dx.doi.org/10.1053/j.sempedsurg.2017.10.006DOI Listing
December 2017
25 Reads

Ogilvie's syndrome treated with an emergency laparotomy, right hemicolectomy and end ileostomy.

BMJ Case Rep 2017 Oct 9;2017. Epub 2017 Oct 9.

The Royal Stoke University Hospital, Stoke-on-Trent, UK.

Acute colonic pseudo-obstruction (ACPO), or Ogilvie's syndrome, is a rare clinical entity in which there is massive non-toxic colonic dilatation in the absence of a mechanically obstructing lesion. It is an important yet poorly recognised cause of surgical morbidity and mortality occurring typically in elderly patients with multiple comorbidities. ACPO can often be reversed conservatively with colonoscopic or nasogastric decompression. Read More

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http://dx.doi.org/10.1136/bcr-2017-220916DOI Listing
October 2017
24 Reads

Colon-sparing surgery for Clostridium difficile.

J Trauma Acute Care Surg 2017 Oct 4. Epub 2017 Oct 4.

aAcademic Department of Military Surgery and Trauma, Royal Centre for Defence Medicine, Queen Elizabeth Hospital, Birmingham, B152TH bNIHR Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital, Birmingham, B152TH cUniversity of Birmingham, Birmingham, UK.

There has been recent evidence from a large multi-center study sponsored by the Eastern Association for the Surgery of Trauma that colon-sparing surgery reduces mortality for patients with severe Clostridium difficile associated disease (CDAD) when compared to total colectomy. Amoebic colitis shares many pathologic and clinical features to CDAD, such as worsening diarrhoea, patchy colonic ulceration and necrosis, toxic megacolon, pseudomembranous colitis, perforation, and death. However, published research regarding amoebic colitis is sparse. Read More

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http://dx.doi.org/10.1097/TA.0000000000001710DOI Listing
October 2017
20 Reads

An unexpected complication following uterine artery embolisation.

BMJ Case Rep 2017 Sep 26;2017. Epub 2017 Sep 26.

Department of Interventional Radiology, Auckland District Health Board, Auckland, New Zealand.

A 35-year-old nulliparous woman underwent uterine artery embolisation (UAE) for heavy menstrual bleeding and anaemia due to fibroids, refractive to medical and surgical treatment.Bilateral UAE was performed after cephazolin prophylaxis and analgesia. Postoperatively, pain and abdominal bloating were prominent. Read More

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http://dx.doi.org/10.1136/bcr-2016-217238DOI Listing
September 2017
18 Reads

Frequency and Variables Associated with Fasting Orders in Inpatients with Ulcerative Colitis: The Audit of Diet Orders-Ulcerative Colitis (ADORE-UC) Study.

Inflamm Bowel Dis 2017 10;23(10):1790-1795

Division of Gastroenterology, Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Introduction: Current clinical practice guidelines suggest that patients with ulcerative colitis (UC) hospitalized because of a disease flare should be offered a normal diet, unless such a diet is not tolerated. Studies of hospitalized patients have demonstrated iatrogenic malnutrition from unjustified or inappropriate nil per os (NPO) or clear liquid diet (CLD) orders. In this study, we aim to characterize the burden of this problem in hospitalized patients with UC. Read More

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http://dx.doi.org/10.1097/MIB.0000000000001244DOI Listing
October 2017
50 Reads

Investigation of the Cross-talk Mechanism in Caco-2 Cells during Infection through Genetic-and-Epigenetic Interspecies Networks: Big Data Mining and Genome-Wide Identification.

Front Immunol 2017 2;8:901. Epub 2017 Aug 2.

Laboratory of Control and Systems Biology, National Tsing Hua University, Hsinchu, Taiwan.

is the leading cause of nosocomial antibiotic-associated diarrhea and the major etiologic agent of pseudomembranous colitis. In severe cases, infection (CDI) can cause toxic megacolon, intestinal perforation, and death. The intestinal epithelium is the first tissue encountered in the adhesion and colonization of , and serves as a physical defense barrier against infection. Read More

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.00
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http://dx.doi.org/10.3389/fimmu.2017.00901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539260PMC
August 2017
23 Reads

Analysis of proteomes released from in vitro cultured eight PCR ribotypes revealed specific expression in PCR ribotypes 027 and 176 confirming their genetic relatedness and clinical importance at the proteomic level.

Gut Pathog 2017 14;9:45. Epub 2017 Aug 14.

Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic.

Background: is the causative agent of . infection (CDI) that could be manifested by diarrhea, pseudomembranous colitis or life-threatening toxic megacolon. The spread of certain strains represents a significant economic burden for health-care. Read More

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http://gutpathogens.biomedcentral.com/articles/10.1186/s1309
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http://dx.doi.org/10.1186/s13099-017-0194-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556371PMC
August 2017
34 Reads

Pathogenicity Locus, Core Genome, and Accessory Gene Contributions to Virulence.

MBio 2017 08 8;8(4). Epub 2017 Aug 8.

Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

is a spore-forming anaerobic bacterium that causes colitis in patients with disrupted colonic microbiota. While some individuals are asymptomatic carriers, symptomatic disease ranges from mild diarrhea to potentially lethal toxic megacolon. The wide disease spectrum has been attributed to the infected host's age, underlying diseases, immune status, and microbiome composition. Read More

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http://dx.doi.org/10.1128/mBio.00885-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550754PMC
August 2017
40 Reads

Molecular epidemiology and antimicrobial susceptibility of Clostridium difficile isolated from the Chinese People's Liberation Army General Hospital in China.

Int J Infect Dis 2018 Feb 20;67:86-91. Epub 2017 Jul 20.

Department of Microbiology, Chinese People's Liberation Army General Hospital, Beijing, China. Electronic address:

Clostridium difficile is a Gram-positive, spore-forming obligate anaerobe responsible for antibiotic-associated diarrhoea. Its virulence is associated with the production of endotoxins A and B and endospores, which can cause symptoms, such as diarrhoea, toxic megacolon, and pseudomembranous colitis. Given the increasing elderly population and the well-recognized problem of over-prescribing of broad-spectrum antibiotics, it is critical to have an understanding of molecular epidemiology and antimicrobial susceptibility in China. Read More

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http://dx.doi.org/10.1016/j.ijid.2017.07.010DOI Listing
February 2018
31 Reads

Clostridium Difficile, Colitis, and Colonoscopy: Pediatric Perspective.

Curr Gastroenterol Rep 2017 Aug;19(8):34

Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Purpose Of The Review: Review tests available for detection of Clostridium difficile (C. Diff) induced disease, including when such tests should be done in children and how they should be interpreted.

Recent Findings: Multiple tests are available for detecting disease due to C. Read More

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http://dx.doi.org/10.1007/s11894-017-0571-zDOI Listing
August 2017
26 Reads