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Case Rep Gastroenterol 2020 Jan-Apr;14(1):220-225. Epub 2020 Apr 27.

Department of Clinical Pediatrics, Manima Not-for-Profit Healthcare and Assistance, Milan, Italy.

Constipation is frequent amongst infants who have undergone surgery for anorectal malformation (ARM). Faecal retention, due to a dysfunctional enteric reflex of defaecation, can cause abdominal cramps, pseudoincontinence and, in the worst cases, megacolon. Prokinetic protocols are used to stimulate at least 1 bowel movement per day, including laxatives, enema, stools softeners and dietary schedules. Read More

Clin J Gastroenterol 2020 Jun 11;13(3):328-333. Epub 2019 Dec 11.

Department of Gastroenterological Surgery, Gastroenterological Cancer, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Acquired isolated hypoganglionosis is a rare intestinal neurological disease, which presents in adulthood with the clinical symptoms of chronic constipation. A 39-year-old man underwent laparoscopic low anterior resection and covering ileostomy for locally advanced-rectal cancer. A 6-month course of postoperative adjuvant chemotherapy was completed, followed by closure of the ileostoma. Read More

Am J Gastroenterol 2019 12;114(12):1847-1856

Division of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Mayo Clinic, Rochester, Minnesota, USA.

Objectives: Although systemic sclerosis (SSc) is known to affect the gastrointestinal (GI) tract, most of the literature focuses on esophageal, small intestinal, or anorectal manifestations. There have been no reviews focused on large bowel SSc complications in over 30 years. The aim of this study is to perform a systematic review of colonic manifestations and complications of SSc. Read More

Transplant Proc 2019 Nov;51(9):3181-3185

Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, California. Electronic address:

Small intestinal transplantation is performed for patients with intestinal failure who failed other surgical and medical treatment. It carries notable risks, including, but not limited to, acute and chronic cellular rejection and graft malfunction. Late severe acute intestinal allograft rejection is associated with increased risk of morbidity and mortality and, in the majority of cases, ends with total enterectomy. Read More

Cir Pediatr 2019 Oct 1;32(4):195-200. Epub 2019 Oct 1.

Hospital Universitario y Politécnico La Fe. Valencia.

Objective: Retrospective and descriptive study of patients with diagnosis of Hirschsprung disease (HD) in whom transanal pull-through was performed in our center.

Material And Methods: All patients with diagnosis of HD in whom transanal surgery was performed between 2006 and 2018 in our center were selected. In all cases laparoscopic biopsy was performed in the previous dilated area. Read More

Epidemiol Infect 2019 10 14;147:e289. Epub 2019 Oct 14.

Division of Nephrology, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.

The risk of metronidazole treatment failure in Clostridium difficile infection (CDI) patients with chronic kidney disease (CKD) or end-stage renal disease in Korea has not been established. We evaluated 481 patients who had been admitted to two secondary hospitals with a diagnosis of, and treatment for, CDI during 2010-2016. CDI patients were divided into three groups according to CKD status: non-CKD (n = 363), CKD (n = 55) and those requiring dialysis (n = 63). Read More

Cir Cir 2019 ;87(5):568-571

Servicio de Cirugía General. Hospital Civil de Tepic Dr. Antonio González Guevara, Servicios de Salud de Nayarit, Tepic, Nayarit, México.

Exposure and infections by Trypanosoma cruzi are the fourth cause of loss of potential life years between parasitic and infectious diseases. We describe the case of a 11-year-old patient with intestinal occlusion, surgically treated with intestinal volvulus, the surgical specimen is sent to histopathology reporting Chagasic megacolon. The age range of presentation is a challenge in the absence of nonspecific symptoms. Read More

Medicine (Baltimore) 2019 Jul;98(30):e16487

Rationale: Idiopathic megacolon (IMC) is a rare condition in young children. The association of indigestible food and IMC has never been mentioned in literature.

Patient Concerns: An 11-year-old boy reported with a 1-year duration of intermittent constipation and abdominal distension after having eaten a large amount of fried sticky rice in 1 consumption. Read More

J Coll Physicians Surg Pak 2019 Jul;29(7):674-676

Department of Surgery, Khyber Teaching Hospital (KTH), Peshawar, Pakistan.

Hirschsprung's disease (HD), a classic disease of childhood, may rarely escape diagnosis and lead to unique presentations in adults. By definition, the disease involves the rectosigmoid colon and is the result of a birth defect characterised by the absence of nerve cells responsible for the movement of the colon; thereby leading to functional obstruction. We present here a case of an 18-year girl who visited multiple doctors for the complaints of chronic constipation, abdominal distension, and failure to thrive since infancy. Read More

Trop Med Health 2019 13;47:38. Epub 2019 Jun 13.

5Department of Microbiology, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-Gun, Saitama 350-0495 Japan.

Background: There are no reports on the prevalence of Chagas disease in Japan. Furthermore, screening programs and access to diagnosis and treatment have not been established. This study aimed to clarify the prevalence of Chagas disease among suspected cases in Japan and provide the reference data required for disease control. Read More

Am J Med Genet A 2019 08 10;179(8):1426-1431. Epub 2019 Jun 10.

Down Syndrome Outpatient Clinic, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.

Down syndrome is the most common human chromosomal disorder. Among clinical findings, one constant concern is the high prevalence of gastrointestinal system alterations. The aim of this study was to determine the prevalence of gastrointestinal disorders at a Down syndrome outpatient clinic during a 10-year follow-up period. Read More

J Obstet Gynaecol Res 2019 Jul 7;45(7):1215-1221. Epub 2019 May 7.

Division of Gastroenterology, Department of Internal Medicine and Medical Specialties, "Sapienza" University of Rome, Umberto I Hospital, Rome, Italy.

Ulcerative colitis (UC) is a chronic inflammatory disease rarely arising during gestation. Because the available information is based on case reports or small retrospective studies, diagnosis may be difficult and treatment is still controversial. A case of toxic megacolon developing in late pregnancy associated to a sudden fetal decompensation is described. Read More

J Pediatr Surg 2019 Nov 24;54(11):2311-2317. Epub 2019 Apr 24.

Colorectal and Hirschsprung Center for Children, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, School of Medicine, Pittsburgh, USA. Electronic address:

Background: At the severe end of the idiopathic constipation spectrum exist patients with chronic idiopathic constipation associated with an enormous megarectosigmoid, among whom few require surgery. We performed transanal proximal rectosigmoidectomy, involving preservation of a 5 cm rectal reservoir, to ameliorate inconsistent and unpredictable outcomes and fecal incontinence occurring in some patients operated on with other techniques.

Methods: We retrospectively observed patients with chronic idiopathic constipation with megarectosigmoid who underwent transanal proximal rectosigmoidectomy during July 2017-May 2018. Read More

J Med Case Rep 2019 Apr 29;13(1):124. Epub 2019 Apr 29.

Department of Visceral Surgery, Carcassonne Hospital, 1060 Chemin de la Madeleine, 111000, Carcassonne, France.

Background: Hirschsprung disease is a neonatal discovery in almost all cases, and the association of Hirschsprung disease in adults with symptomatic intestinal malrotation is unusual. This combination delays diagnosis and can lead to mistake in surgical strategy.

Case Presentation: A 43-year-old patient with a history of colectomy for colonic inertia and megadolichocolon was admitted to the Carcassonne Hospital emergency room for a volvulus of small bowel obstruction in a chronic intestinal obstruction context with episodes of acute, variable-looking occlusive syndromes. Read More

Case Rep Surg 2019 6;2019:4036823. Epub 2019 Mar 6.

Intensive Care Department, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.

Although Schistosoma infection in humans commonly involves the intestines, megacolon is a rare finding. We report a 47-year-old patient who was found to have chronic megacolon. After failing conservative management, he underwent extended hemicolectomy with colorectal anastomosis. Read More

Dig Dis Sci 2019 10 5;64(10):2750-2756. Epub 2019 Apr 5.

Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Division of Gastroenterology and Hepatology, Mayo Clinic, Charlton Bldg., Rm. 8-110, 200 First Street S.W., Rochester, MN, 55905, USA.

Objective: Chronic megacolon is rarely encountered in clinical practice beyond infancy or early childhood. Most cases are sporadic, and some are familial megacolon and present during adolescence or adulthood. There is a need for diagnostic criteria and identifying genetic variants reported in non-Hirschsprung's megacolon. Read More

J Pediatr Surg 2019 Nov 1;54(11):2325-2330. Epub 2019 Mar 1.

Department of General Pediatric Surgery, Robert Debre Children University Hospital, APHP, Paris, France; UMR1149 Inserm, Paris Diderot University, Paris, France. Electronic address:

Aim Of The Study: Congenital Central Hypoventilation Syndrome (CCHS) is a rare affection associated to Hirschsprung disease (HD) in 20% of the cases. Using the French CCHS registry, we described the population of patients suffering from both CCHS and HD reporting the outcome on these patients.

Methods: Medical records were reviewed. Read More

Dis Mon 2019 Dec 2;65(12):100851. Epub 2019 Mar 2.

Division of Gastroenterology, American University of Beirut, Beirut, Lebanon; Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, M2, C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA.

Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disorder of the colon that causes continuous mucosal inflammation extending from the rectum to the more proximal colon, with variable extents. UC is characterized by a relapsing and remitting course. UC was first described by Samuel Wilks in 1859 and it is more common than Crohn's disease worldwide. Read More

Sci Rep 2019 01 24;9(1):492. Epub 2019 Jan 24.

Département des Sciences Biologiques, Université du Québec à Montréal, Montréal, H3C 3P8, Québec, Canada.

Based on the bilateral relationship between the gut microbiota and formation/function of the enteric nervous system (ENS), we sought to determine whether antibiotics-induced dysbiosis might impact the expressivity of genetically-induced ENS abnormalities. To address this, we took advantage of the TashT mouse model of Hirschsprung disease, in which colonic aganglionosis and hypoganglionosis are both much more severe in males. These defects result into two male-biased colon motility phenotypes: either megacolon that is lethal around weaning age or chronic constipation in adults, the latter being also associated with an increased proportion of nitrergic neurons in the distal ENS. Read More

Neurogastroenterol Motil 2019 04 20;31(4):e13550. Epub 2019 Jan 20.

Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota.

Objective: We identified a pedigree over five generations with 49 members, some of whom had chronic megacolon presenting in adolescence or adulthood. We aimed to assess the genetic cause of chronic megacolon through clinical and DNA studies.

Design: After ethical approval and informed consent, family members provided answers to standard bowel disease questionnaires, radiological or surgical records, and DNA (buccal mucosal scraping). Read More

J Med Case Rep 2019 Jan 13;13(1):10. Epub 2019 Jan 13.

Sickle Cell Unit, Caribbean Institute for Health Research, The University of the West Indies, Kingston 7, Jamaica.

Background: It is important that multiple genetic diagnoses are not missed. This case report describes the clinical features and management of a patient with co-inheritance of Waardenburg syndrome type 4 or Waardenburg-Shah syndrome, an extremely rare disease, and homozygous sickle cell disease not uncommon in the Caribbean. This case is unusual as it may be the first documented case of the co-inheritance of both these diseases. Read More

J Clin Immunol 2019 01 3;39(1):81-89. Epub 2019 Jan 3.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Department of Pediatrics, University of Washington, Seattle, WA, USA.

The association of immunodeficiency-related vaccine-derived rubella virus (iVDRV) with cutaneous and visceral granulomatous disease has been reported in patients with primary immunodeficiency disorders (PIDs). The majority of these PID patients with rubella-positive granulomas had DNA repair disorders. To support this line of inquiry, we provide additional descriptive data on seven previously reported patients with Nijmegen breakage syndrome (NBS) (n = 3) and ataxia telangiectasia (AT) (n = 4) as well as eight previously unreported patients with iVDRV-induced cutaneous granulomas and DNA repair disorders including NBS (n = 1), AT (n = 5), DNA ligase 4 deficiency (n = 1), and Artemis deficiency (n = 1). Read More

J Pediatr Surg 2019 Jul 27;54(7):1379-1383. Epub 2018 Nov 27.

Department of Pediatric Surgery, Stavropol State Medical University, 310 Mira Str., 355017, Stavropol, Russian Federation. Electronic address:

Background: Chronic constipation in children is associated with primary megarectum. This study investigated outcomes of surgical treatment of idiopathic megarectum in children.

Methods: This retrospective comparative study included 52 children with idiopathic megarectum (mean age, 9. Read More

Am J Med Genet A 2019 02 14;179(2):243-248. Epub 2018 Dec 14.

Department of Otolaryngology - Head and Neck Surgery, The Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Waardenburg syndrome (WS) is a genetic disorder characterized by hearing loss and pigmentary abnormalities with variable penetrance. Though heterozygous mutations in MITF are a major cause for Waardenburg syndrome type 2 (WS2), homozygous mutations in this gene and the associated phenotype have been rarely characterized. In this study, we identified a novel p. Read More

Eur J Pediatr Surg 2019 Feb 10;29(1):97-101. Epub 2018 Dec 10.

Department of Paediatric Surgery, Noah's Ark Children's Hospital for Wales, Cardiff, United Kingdom.

Introduction:  The U.K. National Institute for Health and Clinical Excellence (NICE) specify the following indications for performing rectal biopsy to rule out Hirschsprung's disease (HSD): (1) passage of meconium > 48 hours; (2) constipation since first few weeks of life; (3) chronic abdominal distension with vomiting; (4) family history of HSD; and (5) faltering growth in addition to any other indication. Read More

World J Nucl Med 2018 Oct-Dec;17(4):249-252

Hospital de Base do Distrito Federal - Nuclear Medicine Service, Brasília, Brasil.

The aim of this study was to assess the colonic transit in children and teenagers with chronic constipation. Twenty patients from 1.5 to 16 years old were included (mean age = 6. Read More

JAAPA 2018 Dec;31(12):30-33

Dan M. Tzizik practices in the ED at Portsmouth (N.H.) Regional Hospital. Roy A. Borchardt is supervisor of advanced practice providers at M.D. Anderson Cancer Center's Department of Infectious Diseases, Infection Control and Employee Health, in Houston, Tex. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Chagas disease is a parasite infection primarily transmitted to humans via the bite of triatomine insect vectors. Up to 8 million people are estimated to be infected with Chagas disease in the Americas. Patients who do not receive treatment can develop severe cardiac debility, gastrointestinal organ dysfunction, and may die. Read More

Pediatr Surg Int 2019 Feb 19;35(2):215-220. Epub 2018 Nov 19.

Japanese Study Group for Allied Disorders of Hirschsprung's Disease, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Purpose: Acquired isolated hypoganglionosis (A-IH) is a late-onset intestinal pseudo-obstruction disorder and shows different pathophysiological findings from congenital isolated hypoganglionosis (C-IH). In this study, we retrospectively examined five cases of A-IH and investigated the features of A-IH.

Methods: Five cases of A-IH were extracted from a nationwide retrospective cohort study in 10 years, from which totally 355 cases of Allied Disorders of Hirschsprung's Disease (ADHD) were collected. Read More

BMC Infect Dis 2018 Nov 3;18(1):547. Epub 2018 Nov 3.

Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes, s/n - Monte Alegre, Ribeirão Preto, SP, 14049-900, Brazil.

Background: The Leuconostoc mesenteroides are members of the Streptococcae family and currently has been recognized as potential pathogens. This case describes a bacteremia caused by L. mesenteroides in an immunocompetent patient affected by Chagas disease. Read More

Wounds 2018 Oct;30(10):E102-E104

Department of Surgery, Swedish Medical Center, Seattle, WA.

Introduction: Aspergillus is a rare cause of surgical site infection most often seen in immunocompromised patients undergoing cardiac, transplant, ophthalmologic, or burn operations; an unusual case following a colon resection is presented here.

Case Report: The authors report a case of an invasive Aspergillus fumigatus infection following a subtotal colectomy for toxic megacolon. The patient was on antibiotics following the operation and chronic immunosuppression with steroids and infliximab. Read More

World J Urol 2019 Jul 9;37(7):1395-1402. Epub 2018 Oct 9.

Intertryp, IRD-Cirad, Université de Montpellier, Montpellier, France.

Purpose: To describe and give an estimation of the prevalence of urinary disorders in chronic Chagas disease, since most clinical research has been centered on the description of the cardiac and digestive forms.

Methods: To explore this topic, a cross-sectional study was conducted in 137 Bolivian adults of both sexes suffering from symptomatic chronic Chagas disease. All patients presenting confirmed chagasic cardiomyopathy, megacolon or both underwent a urologic symptom questionnaire, uroflowmetry, urinary tract ultrasonography and a creatinine assay. Read More

Clin Radiol 2018 12 17;73(12):1041-1045. Epub 2018 Sep 17.

Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai cho, Showa-ku, Nagoya, Japan.

Aim: To present the technique and the diagnostic accuracy of the air test to diagnose Hirschsprung's disease (HD).

Materials And Methods: Children who attended hospital for chronic constipation (CC) between January 2012 and December 2016 for whom the air test was performed were enrolled. The test was conducted during contrast enema under fluoroscopic observation using 20-50 ml injections of air into the rectum through a 10 F Nelaton catheter. Read More

Dermatol Online J 2018 Jun 15;24(6). Epub 2018 Jun 15.

Department of Dermatology and Venereology, Istanbul Faculty of Medicine, Istanbul University, Istanbul.

We herein present a 4 year-old boy with Waardenburg-Shah syndrome who developed Jacquet erosive diaper dermatitis following a total colectomy and ileoanal anastomosis procedure for Hirschsprung disease. The diagnosis was made according to history and typical clinical findings. Complete resolution of the recalcitrant lesions after an ileostomy procedure supported the diagnosis. Read More

BMJ Case Rep 2018 Aug 20;2018. Epub 2018 Aug 20.

General Surgery, Newham University Hospital, London, UK.

BMJ Case Rep 2018 Aug 8;2018. Epub 2018 Aug 8.

Department of Surgery, University Hospital Limerick, Limerick, Ireland.

A 31-year-old male patient with chronic constipation of unknown aetiology presented emergently with worsening nausea, vomiting and abdominal distension of one week duration. On examination, his abdomen was distended with minimal tenderness. A plain film of the abdomen demonstrated severe faecal loading. Read More

Ann Surg 2018 09;268(3):497-505

Children's Hospital of Wisconsin and Division of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI.

Objective: This prospective observational study was designed to assess Pediatric Quality of Life (PedsQL) after surgical treatment for congenital diaphragmatic hernia (CDH), esophageal atresia/tracheoesophageal fistula (EA/TEF), Hirschsprung disease (HD), gastroschisis (GAS), omphalocele (OMP), and necrotizing enterocolitis (NEC).

Summary Of Background Data: Improvements in neonatal and surgical care have led to increased survival for many newborn conditions. Quality of life in these patients is seldom explored in a longitudinal manner. Read More

Endoscopy 2018 10 3;50(10):E281-E283. Epub 2018 Jul 3.

Centro de Innovaciones Digestivas Martínez-Alcalá (CIDMA), Seville, Spain.

J Laparoendosc Adv Surg Tech A 2018 Jul 29;28(7):894-898. Epub 2018 Jun 29.

Cardinal Glennon Children's Hospital, Saint Louis University , Saint Louis, Missouri.

Background: The Soave pull-through for Hirschsprung's disease leaves a muscular cuff of aganglionosis surrounding the pull-through. In some patients, this cuff can extrinsically compress the pull-through, leading to chronic enterocolitis and failure to thrive. We describe a novel technique for managing the Soave cuff as an alternative to a complete redo pull-through. Read More

Intern Emerg Med 2018 Sep 12;13(6):881-887. Epub 2018 Jun 12.

Department of Internal Medicine, HCA GME Consortium's Internal Medicine Program, University of Central Florida College of Medicine, Gainesville, FL, USA.

Toxic megacolon (TM) is a potentially fatal condition characterized by non-obstructive colonic dilatation and systemic toxicity. It is most commonly caused by inflammatory bowel disease (IBD). Limited data for TM are available demonstrating incidence, in-hospital outcomes and predictors of mortality. Read More

Pediatr Int 2018 May;60(5):400-410

The guideline establishment group for allied disorders of Hirschsprung's disease, Science Research, Ministry of Health Labour and Welfare, Fukuoka, Japan.

Background: Despite the presence of ganglion cells in the rectum, some patients have symptoms similar to those of Hirschsprung's disease. A consensus has yet to be established regarding the terminology for these diseases. We defined this group of diseases as "allied disorders of Hirschsprung's disease" and compiled these guidelines to facilitate accurate clinician diagnosis and provide appropriate treatment strategies for each disease. Read More

Zhongguo Dang Dai Er Ke Za Zhi 2018 May;20(5):428-432

Department of Neonatal Surgery, Shengjing Hospital of China Medical University, Shenyang 110003, China.

Hirschsprung′s disease (HSCR) is one of the major causes of chronic incomplete intestinal obstruction in children. HSCR is considered a type of neurocristopathy caused by no colonization of ganglion cells on some parts of the bowel wall due to abnormal termination of the migration of vagal neural cells during embryonic development. This disease can be classified into different types according to the length of the affected intestinal canal. Read More

Am J Case Rep 2018 May 14;19:557-561. Epub 2018 May 14.

Department of General Surgery, Colorectal Surgery Section, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

BACKGROUND Intestinal hypoganglionosis is very rare and accounts for 3% to 5% of all classified congenital intestinal innervation disorders. Isolated hypoganglionosis of the colon is a particularly rare form of the disease, and differential diagnosis includes association with Hirschsprung's disease and chronic intestinal pseudo-obstruction (CIPO) related to visceral myopathies. Most cases are diagnosed at an early age or in childhood with only a few cases reported in adults. Read More

Rozhl Chir Spring 2018;97(3):133-138

Hirschsprungs disease (HD) in adults is extremely rare, only three publications in Czech and Czechoslovak journals making reference to the condition after childhood. We present two cases of adult patients with HD. The first case is a 46-year-old male patient suffering from chronic constipation since childhood and diagnosed with megacolon at the age of 16; however, no further detailed diagnosis was done. Read More

Front Microbiol 2018 1;9:351. Epub 2018 Mar 1.

Centro de Biología Molecular Severo Ochoa (CSIC), Madrid, Spain.

Chagas disease is a multisystemic disorder caused by the protozoan parasite , which affects ~8 million people in Latin America, killing 7,000 people annually. Chagas disease is one of the main causes of death in the endemic area and the leading cause of infectious myocarditis in the world. infection induces two phases, acute and chronic, where the infection is initially asymptomatic and the majority of patients will remain clinically indeterminate for life. Read More

Parasitol Res 2018 Apr 22;117(4):1147-1158. Epub 2018 Feb 22.

Morphology Department, Federal University of Minas Gerais, Belo Horizonte, 31.270-901, Brazil.

Chagas disease is an infection caused by the parasite Trypanosoma cruzi that affects millions of people worldwide and is endemic in Latin America. Megacolon is the most frequent complication of the digestive chronic form and happens due to lesions of the enteric nervous system. The neuronal lesions seem to initiate in the acute phase and persist during the chronic phase, albeit the mechanisms involved in this process are still debated. Read More

Vojnosanit Pregl 2017 Jan;74(1):78-80

Introduction: Transverse colon volvulus is an uncommon cause of bowel obstruction in general. Predisposing factors are mental retardation, dysmotility disorders, chronic constipation and congenital megacolon.

Case Report: We presented transverse colon volvulus in a 16-year-old boy with cerebral palsy. Read More

Afr J Paediatr Surg 2018 Jan-Mar;15(1):31-35

Lilavati Hospital and Research Centre, Mumbai, Maharashtra, India.

Background: Chronic refractory constipation (CRC) is an uncommon type of constipation. These children have persistent symptoms even after treatment with high dose laxatives, which may cause abdominal distension, vomiting, cramping and bloating. We conducted this study to assess the diagnostic and therapeutic role of anorectal myomectomy in children with CRC. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2017 Dec;20(12):1339-1341

Department of Colorectal Surgery, Changhai Hospital, Shanghai 200433, China.

Surgery, as one of the methods for the treatment of chronic constipation, is the final choice after the failure of non-surgical treatment with its specific particularity. The history of surgical treatment of chronic constipation is complex and tortuous. How to select operation among many kinds of surgery, and control risk is difficult for clinician. Read More

J Pediatr Surg 2017 Dec 2;52(12):2001-2005. Epub 2017 Sep 2.

Department of Pediatric Surgery, Research Field in Medical and Health Sciences, Medical and Dental Area, Research and Education Assembly, Kagoshima University, Kagoshima, Japan. Electronic address:

Background/purpose: Hirschsprung disease (HD) is considered curable, but the postoperative bowel function is not always satisfactory. In this study, we evaluated the general condition, bowel function, and social performance in adults who were older than 17years of age who had undergone definitive operations in childhood.

Method: From 1984 to 2016, 110 patients with HD underwent definitive surgery at our institute. Read More

J Laparoendosc Adv Surg Tech A 2018 Apr 30;28(4):471-475. Epub 2017 Nov 30.

Department of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China .

Background: Laparoscopic surgery is widely used in the treatment of Hirschsprung's disease (HD). However, constipation and soiling are still the main long-term complications. A new type of anastomosis, which is characterized by a heart-shaped colorectal anastomosis after splitting the posterior rectum wall to 0. Read More