413 results match your criteria Megacolon Acute


Chagas disease: An underrecognized diagnosis.

JAAPA 2018 Dec;31(12):30-33

Dan M. Tzizik practices in the ED at Portsmouth (N.H.) Regional Hospital. Roy A. Borchardt is supervisor of advanced practice providers at M.D. Anderson Cancer Center's Department of Infectious Diseases, Infection Control and Employee Health, in Houston, Tex. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Chagas disease is a parasite infection primarily transmitted to humans via the bite of triatomine insect vectors. Up to 8 million people are estimated to be infected with Chagas disease in the Americas. Patients who do not receive treatment can develop severe cardiac debility, gastrointestinal organ dysfunction, and may die. Read More

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http://dx.doi.org/10.1097/01.JAA.0000547749.92933.6aDOI Listing
December 2018
2 Reads

Megabowel and Giant Fecaloma: a Surgical Condition?

J Gastrointest Surg 2018 Sep 4. Epub 2018 Sep 4.

Department of Surgery, Traumatology and Acute Care, Hôpital du Sacré-Coeur de Montréal, Montreal, Québec, Canada.

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http://link.springer.com/10.1007/s11605-018-3919-2
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http://dx.doi.org/10.1007/s11605-018-3919-2DOI Listing
September 2018
15 Reads

A Rare Case of Adult-Onset Rectosigmoid Hypoganglionosis.

Am J Case Rep 2018 May 14;19:557-561. Epub 2018 May 14.

Department of General Surgery, Colorectal Surgery Section, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

BACKGROUND Intestinal hypoganglionosis is very rare and accounts for 3% to 5% of all classified congenital intestinal innervation disorders. Isolated hypoganglionosis of the colon is a particularly rare form of the disease, and differential diagnosis includes association with Hirschsprung's disease and chronic intestinal pseudo-obstruction (CIPO) related to visceral myopathies. Most cases are diagnosed at an early age or in childhood with only a few cases reported in adults. Read More

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http://dx.doi.org/10.12659/AJCR.907109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983074PMC
May 2018
2 Reads

Clinical course of severe colitis: a comparison between Crohn’s Disease and ulcerative colitis.

J Biol Regul Homeost Agents 2018 Mar-Apr;32(2):415-423

DIBIMIS, Ospedali Riuniti Villa Sofia – Vincenzo Cervello, Division of Internal Medicine, Palermo, Italy.

Few data are available about the clinical course of severe colonic Crohn’s disease (CD). The aim of this study is to describe the clinical course of severe Crohn’s colitis in a patient cohort with isolated colonic or ileocolonic CD, and to compare it with the clinical course of patients with severe ulcerative colitis (UC). Thirty-four patients with severe Crohn’s colitis were prospectively identified in our cohort of 593 consecutive hospitalized patients through evaluation of the Crohn’s Disease Activity Index score and the Harvey-Bradshaw Index. Read More

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June 2018
2 Reads

Endoscopic Treatment of Ileal Pouch Sinus.

Authors:
Nan Lan Bo Shen

Inflamm Bowel Dis 2018 Jun;24(7):1510-1519

Interventional Inflammatory Bowel Disease (i-IBD) Unit, Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

Background And Aims: Pouch sinus is a serious complication in patients undergoing ileal pouch-anal anastomosis. The aim of this study was to verify the efficacy and safety of endoscopic needle knife sinusotomy (NKSi) in the management of pouch sinus.

Methods: All consecutive patients with a pouch sinus treated with NKSi from 2008 to 2016 were identified. Read More

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http://dx.doi.org/10.1093/ibd/izy029DOI Listing
June 2018
14 Reads

[Hirschsprungs disease in adults two case reports and review of the literature].

Rozhl Chir 2018 ;97(3):133-138

Hirschsprungs disease (HD) in adults is extremely rare, only three publications in Czech and Czechoslovak journals making reference to the condition after childhood. We present two cases of adult patients with HD. The first case is a 46-year-old male patient suffering from chronic constipation since childhood and diagnosed with megacolon at the age of 16; however, no further detailed diagnosis was done. Read More

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January 2018
5 Reads

Regulatory Lymphoid and Myeloid Cells Determine the Cardiac Immunopathogenesis of Infection.

Front Microbiol 2018 1;9:351. Epub 2018 Mar 1.

Centro de Biología Molecular Severo Ochoa (CSIC), Madrid, Spain.

Chagas disease is a multisystemic disorder caused by the protozoan parasite , which affects ~8 million people in Latin America, killing 7,000 people annually. Chagas disease is one of the main causes of death in the endemic area and the leading cause of infectious myocarditis in the world. infection induces two phases, acute and chronic, where the infection is initially asymptomatic and the majority of patients will remain clinically indeterminate for life. Read More

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http://dx.doi.org/10.3389/fmicb.2018.00351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838393PMC
March 2018
9 Reads

Mast cell-nerve interaction in the colon of Trypanosoma cruzi-infected individuals with chagasic megacolon.

Parasitol Res 2018 Apr 22;117(4):1147-1158. Epub 2018 Feb 22.

Morphology Department, Federal University of Minas Gerais, Belo Horizonte, 31.270-901, Brazil.

Chagas disease is an infection caused by the parasite Trypanosoma cruzi that affects millions of people worldwide and is endemic in Latin America. Megacolon is the most frequent complication of the digestive chronic form and happens due to lesions of the enteric nervous system. The neuronal lesions seem to initiate in the acute phase and persist during the chronic phase, albeit the mechanisms involved in this process are still debated. Read More

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http://link.springer.com/10.1007/s00436-018-5792-z
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http://dx.doi.org/10.1007/s00436-018-5792-zDOI Listing
April 2018
5 Reads

Gastrointestinal Motility Problems in Critically Ill Patients.

Crit Care Nurs Clin North Am 2018 Mar 29;30(1):109-121. Epub 2017 Nov 29.

College of Health Sciences, School of Nursing, Walden University, 100 Washington Avenue South, Suite 900, Minneapolis, MN 55401, USA.

Gastrointestinal (GI) motility problems are common complications in critical care patients. GI problems contribute to an increased risk of morbidity and mortality. Toxic megacolon (TM) is a type of acquired megacolon categorized as a medical emergency and includes severe inflammation affecting all layers of the colon wall. Read More

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http://dx.doi.org/10.1016/j.cnc.2017.10.010DOI Listing
March 2018
12 Reads

Transverse colon volvulus in neurologicaly imparied patient as an emergency surgical condition: A case report.

Vojnosanit Pregl 2017 Jan;74(1):78-80

Introduction: Transverse colon volvulus is an uncommon cause of bowel obstruction in general. Predisposing factors are mental retardation, dysmotility disorders, chronic constipation and congenital megacolon.

Case Report: We presented transverse colon volvulus in a 16-year-old boy with cerebral palsy. Read More

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http://dx.doi.org/10.2298/VSP150911015MDOI Listing
January 2017
14 Reads

Adaptive Returns of Deficient Systemic Plasma Immunoglobulin G Levels as Rehabilitation Biomarker After Emergency Colectomy for Fulminant Ulcerative Colitis.

Clin Med Insights Gastroenterol 2017 13;10:1179552217746692. Epub 2017 Dec 13.

Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN, USA.

Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis (IPAA) is the standard surgical treatment for ulcerative colitis (UC). Emergency colectomies are performed for fulminant colitis (ie, toxic megacolon, profuse bleeding, perforation, or sepsis). The RPC and IPAA involve manipulation of the proximal ileum, which may influence the essential physiological function of gut-associated lymphoid tissues. Read More

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http://dx.doi.org/10.1177/1179552217746692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734426PMC
December 2017
26 Reads

Investigation of Clostridium difficile ribotypes in symptomatic patients of a German pediatric oncology center.

Eur J Pediatr 2018 Mar 22;177(3):403-408. Epub 2017 Dec 22.

Institute of Medical Microbiology and Hygiene, National Consultant Laboratory for Clostridium difficile, University of Saarland Medical Centre, Homburg, Germany.

In a German pediatric oncology unit, the attending physicians diagnosed 27 cases of Clostridium difficile-associated disease (CDI) from January 01, 2010 to October 31, 2013. This refers to a CDI incidence density of 2.0/1000 inpatient days. Read More

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http://link.springer.com/10.1007/s00431-017-3070-1
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http://dx.doi.org/10.1007/s00431-017-3070-1DOI Listing
March 2018
16 Reads

[German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS) position statement on endoscopic decompression in acute Ileus].

Z Gastroenterol 2017 Dec 6;55(12):1499-1508. Epub 2017 Dec 6.

Klinik und Poliklinik für Innere Medizin A, Universitätsklinikum Greifswald.

In patients with ileus with dilated intestine in imaging studies, endoscopic decompression appears a feasible option. However, its use is often uncritical and without scientific evidence. Before considering endoscopic intervention, CT-imaging should differentiate between mechanical obstruction and paralytic ileus/intestinal pseudo-obstruction. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-120351
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http://dx.doi.org/10.1055/s-0043-120351DOI Listing
December 2017
20 Reads

Management of acute severe ulcerative colitis in children.

Semin Pediatr Surg 2017 Dec 5;26(6):367-372. Epub 2017 Oct 5.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Division of Pediatric Surgery, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania. Electronic address:

The incidence of pediatric-onset ulcerative colitis (UC) is rising. Children often present with a more severe disease phenotype as compared to adults with over a third requiring hospitalization for the management of acute severe ulcerative colitis (ASUC). Further, in pediatric patients presenting with inflammatory bowel disease (IBD) limited to the colon, a definitive diagnosis of UC vs. Read More

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http://dx.doi.org/10.1053/j.sempedsurg.2017.10.006DOI Listing
December 2017
18 Reads

Ogilvie's syndrome treated with an emergency laparotomy, right hemicolectomy and end ileostomy.

BMJ Case Rep 2017 Oct 9;2017. Epub 2017 Oct 9.

The Royal Stoke University Hospital, Stoke-on-Trent, UK.

Acute colonic pseudo-obstruction (ACPO), or Ogilvie's syndrome, is a rare clinical entity in which there is massive non-toxic colonic dilatation in the absence of a mechanically obstructing lesion. It is an important yet poorly recognised cause of surgical morbidity and mortality occurring typically in elderly patients with multiple comorbidities. ACPO can often be reversed conservatively with colonoscopic or nasogastric decompression. Read More

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http://dx.doi.org/10.1136/bcr-2017-220916DOI Listing
October 2017
19 Reads

Colon-sparing surgery for Clostridium difficile.

J Trauma Acute Care Surg 2017 Oct 4. Epub 2017 Oct 4.

aAcademic Department of Military Surgery and Trauma, Royal Centre for Defence Medicine, Queen Elizabeth Hospital, Birmingham, B152TH bNIHR Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital, Birmingham, B152TH cUniversity of Birmingham, Birmingham, UK.

There has been recent evidence from a large multi-center study sponsored by the Eastern Association for the Surgery of Trauma that colon-sparing surgery reduces mortality for patients with severe Clostridium difficile associated disease (CDAD) when compared to total colectomy. Amoebic colitis shares many pathologic and clinical features to CDAD, such as worsening diarrhoea, patchy colonic ulceration and necrosis, toxic megacolon, pseudomembranous colitis, perforation, and death. However, published research regarding amoebic colitis is sparse. Read More

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http://dx.doi.org/10.1097/TA.0000000000001710DOI Listing
October 2017
13 Reads

Predictors of emergency colectomy in patients admitted with acute severe ulcerative colitis.

S Afr J Surg 2017 Sep;55(3):20-26

Division of Gastroenterology, Department of Medicine, Groote Schuur Hospital and University of Cape Town.

Background: Acute Severe Ulcerative Colitis (ASUC) is a life-threatening condition which requires urgent and aggressive medical therapy to reduce mortality, morbidity and avoid surgery. To facilitate this process, it is essential to identify patients at high risk of poor outcomes and emergency colectomy. Numerous such risk factors have been described in Western literature, however there is no local data addressing this issue. Read More

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September 2017
15 Reads

Infectious diseases causing autonomic dysfunction.

Clin Auton Res 2018 02 20;28(1):67-81. Epub 2017 Jul 20.

Neurology Department, Raigmore Hospital, Inverness, UK.

Objectives: To review infectious diseases that may cause autonomic dysfunction.

Methods: Review of published papers indexed in medline/embase.

Results: Autonomic dysfunction has been reported in retrovirus (human immunodeficiency virus (HIV), human T-lymphotropic virus), herpes viruses, flavivirus, enterovirus 71 and lyssavirus infections. Read More

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http://link.springer.com/10.1007/s10286-017-0452-4
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http://dx.doi.org/10.1007/s10286-017-0452-4DOI Listing
February 2018
46 Reads

Myenteric neuroprotective role of aspirin in acute and chronic experimental infections with Trypanosoma cruzi.

Neurogastroenterol Motil 2017 Oct 19;29(10):1-13. Epub 2017 May 19.

Department of Histology, State University of Londrina, Londrina, Paraná, Brazil.

Background: Experimental and clinical studies have shown that myenteric neuron cell death during infection with Trypanosoma cruzi mainly occurs in the esophagus and colon, resulting in megaesophagus and megacolon, respectively. Evidence suggests that the cyclooxygenase enzyme (COX) is involved in the T. cruzi invasion process. Read More

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http://dx.doi.org/10.1111/nmo.13102DOI Listing
October 2017
14 Reads

Is abdominal CT useful for the management of patients with severe acute colitis complicating inflammatory bowel disease? A study in 54 consecutive patients.

Colorectal Dis 2017 Apr;19(4):O97-O102

Department of Colorectal Surgery, Beaujon Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris VII, Clichy, France.

Aim: To evaluate the contribution of CT for the management of patients with severe acute exacerbation of colitis (SAC) complicating inflammatory bowel disease (IBD); in particular, its contribution to surgical decision making.

Method: All patients who were admitted to our institution for SAC complicating IBD were divided into two groups: group A (those who received surgical treatment); and group B (those who received medical treatment). Admission CT results were compared between groups. Read More

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http://dx.doi.org/10.1111/codi.13640DOI Listing
April 2017
12 Reads

The Surgical Treatment of Toxic Megacolon in Hirschsprung Disease.

Pediatr Emerg Care 2016 Nov;32(11):785-788

From the Departments of *Pediatric Surgery and †Pediatrics, University of Mannheim, Medical Faculty of Heidelberg, Mannheim, Germany.

Objectives: Enterocolitis remains the most significant cause of morbidity and mortality in Hirschsprung disease (HD). It could progress into toxic megacolon (TM)-acute dilatation of the colon as accompanying toxic complication of Hirschsprung enterocolitis. It is a devastating complication, especially in infants with so far undiagnosed HD. Read More

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http://dx.doi.org/10.1097/PEC.0000000000000444DOI Listing
November 2016
17 Reads

[Clostridium difficile infection : What is currently available for treatment?]

Authors:
A Stallmach

Internist (Berl) 2016 Dec;57(12):1182-1190

Klinik für Innere Medizin IV (Gastroenterologie, Hepatologie und Infektiologie), Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Am Klinikum 1, 07747, Jena, Deutschland.

Clostridium difficile (C. difficile) is an anaerobic, Gram-positive, spore-forming, toxin-secreting bacillus. It is transmitted via a fecal-oral route and can be found in 1-3 % of the healthy population. Read More

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http://link.springer.com/10.1007/s00108-016-0149-0
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http://dx.doi.org/10.1007/s00108-016-0149-0DOI Listing
December 2016
10 Reads

MANAGEMENT OF ACUTE SEVERE ULCERATIVE COLITIS: A CLINICAL UPDATE.

Arq Bras Cir Dig 2016 Jul-Sep;29(3):201-205

Discipline of Coloproctology, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, SP, Brazil.

Introduction: : Acute severe colitis is a potentially lethal medical emergency and, even today, its treatment remains a challenge for clinicians and surgeons. Intravenous corticoid therapy, which was introduced into the therapeutic arsenal in the 1950s, continues to be the first-line treatment and, for patients who are refractory to this, the rescue therapy may consist of clinical measures or emergency colectomy.

Objective: : To evaluate the indications for and results from drug rescue therapy (cyclosporine, infliximab and tacrolimus), and to suggest a practical guide for clinical approaches. Read More

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http://dx.doi.org/10.1590/0102-6720201600030017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074675PMC
March 2017
29 Reads

An elusive cause of perianal pain in a patient with Hirschsprung's disease.

BMJ Case Rep 2016 Oct 12;2016. Epub 2016 Oct 12.

Madras Medical College, Institute of Surgical Gastroenterology, Chennai, Tamilnadu, India.

A 23-year-old woman presented to the outpatients department with symptoms of acute onset perianal pain of 2 weeks' duration and constipation. She was a known case of Hirschsprung's disease and was operated on in infancy. Rectal examination ruled out acute fissure or perianal sepsis, and subsequent colonoscopy was normal. Read More

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http://dx.doi.org/10.1136/bcr-2016-215173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073638PMC
October 2016
12 Reads

Anorectal emergencies.

Authors:
Varut Lohsiriwat

World J Gastroenterol 2016 Jul;22(26):5867-78

Varut Lohsiriwat, Division of Colon and Rectal Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Anorectal emergencies refer to anorectal disorders presenting with some alarming symptoms such as acute anal pain and bleeding which might require an immediate management. This article deals with the diagnosis and management of common anorectal emergencies such as acutely thrombosed external hemorrhoid, thrombosed or strangulated internal hemorrhoid, bleeding hemorrhoid, bleeding anorectal varices, anal fissure, irreducible or strangulated rectal prolapse, anorectal abscess, perineal necrotizing fasciitis (Fournier gangrene), retained anorectal foreign bodies and obstructing rectal cancer. Sexually transmitted diseases as anorectal non-surgical emergencies and some anorectal emergencies in neonates are also discussed. Read More

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http://www.wjgnet.com/1007-9327/full/v22/i26/5867.htm
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http://dx.doi.org/10.3748/wjg.v22.i26.5867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948271PMC
July 2016
39 Reads

Neonatal sigmoid volvulus.

J Pediatr Surg 2016 Nov 5;51(11):1782-1785. Epub 2016 Jul 5.

Department of Pediatric Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address:

Background: Neonatal sigmoid volvulus is a rare entity. It is associated with Hirschsprung's disease. Presentation is acute abdominal distention, vomiting and obstipation. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2016.06.017DOI Listing
November 2016
9 Reads
1 Citation
1.311 Impact Factor

A Case of Severe Ulcerative Colitis with Colonic Dilatation caused by Renal Mucinous Tubular and Spindle Cell Carcinoma.

Euroasian J Hepatogastroenterol 2016 Jul-Dec;6(2):190-193. Epub 2016 Dec 1.

Department of Gastroenterology and Hepatology, Wroclaw Medical University, Wroclaw, Polland.

We present a case of ulcerative colitis (UC) in a patient during the first severe relapse with colonic dilatation and coexisting of giant renal tumor. Kidney tumor was constricting on colon and imitating toxic megacolon (TM). The patient with severe acute colitis (SAC) was admitted to the Department of Gastroenterology and Hepatology with inflammatory bowel disease (IBD) diagnosed in the previous month, based on clinical symptoms, endoscopy, and histopathology results. Read More

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http://dx.doi.org/10.5005/jp-journals-10018-1198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578594PMC
December 2016
8 Reads

Sigmoid volvulus: an uncommon complication of Hirschsprung's disease.

BMJ Case Rep 2016 May 26;2016. Epub 2016 May 26.

Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Sigmoid volvulus is a rare and potentially life-threatening condition that is usually seen in adults, however, when diagnosed in children, it is often associated with Hirschsprung's disease (HD). We report a case of an 11-year-old boy who presented with a history of constipation since 1.5 months of age, with acute onset of severe abdominal pain and marked distention of the abdomen. Read More

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http://dx.doi.org/10.1136/bcr-2016-214693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885264PMC
May 2016
6 Reads

Giant Fecaloma Causing Small Bowel Obstruction: Case Report and Review of the Literature.

Bull Emerg Trauma 2015 Apr;3(2):70-2

Department of General and Minimal Access Surgery, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, J & K, India.

Fecaloma is a mass of hardened feces being impacted mostly in rectum and sigmoid. The most common sites of the fecaloma is the sigmoid colon and the rectum. There are several causes of fecaloma and have been described in association with Hirschsprung's disease, psychiatric patients, Chagas disease, both inflammatory and neoplastic, and in patients suffering with chronic constipation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771270PMC
April 2015
9 Reads

Acute colonic complications in a patient with Chagas disease.

Rev Esp Enferm Dig 2016 Dec;108(12):841

UGC Aparato Digestivo, Hospital Universitario Virgen de la Victoria.

We present the case of a young bolivian woman who suffered two acute and impressive colonic complications due to a Chagasic megacolon. Read More

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https://online.reed.es/fichaArticulo.aspx?iarf=683764742234-
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http://dx.doi.org/10.17235/reed.2016.4193/2016DOI Listing
December 2016
4 Reads

Enteric Neuronal Damage, Intramuscular Denervation and Smooth Muscle Phenotype Changes as Mechanisms of Chagasic Megacolon: Evidence from a Long-Term Murine Model of Trypanosoma cruzi Infection.

PLoS One 2016 5;11(4):e0153038. Epub 2016 Apr 5.

Departamento de Patologia Geral Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

We developed a novel murine model of long-term infection with Trypanosoma cruzi with the aim to elucidate the pathogenesis of megacolon and the associated adaptive and neuromuscular intestinal disorders. Our intent was to produce a chronic stage of the disease since the early treatment should avoid 100% mortality of untreated animals at acute phase. Treatment allowed animals to be kept infected and alive in order to develop the chronic phase of infection with low parasitism as in human disease. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153038PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821538PMC
August 2016
16 Reads

Hirschsprung disease with debut in adult age as acute intestinal obstruction: case report.

Rev Esp Enferm Dig 2016 Nov;108(11):742-746

Unidad de Trasplante Hepático, Hospital Universitario Virgen del Rocío, ESPAÑA.

Hirschsprung's disease is characterized by absence of ganglion cells in submucosal and myenteric plexus of distal bowel. Most cases become manifest during the neonatal period, but in rare instances, this disease is initially diagnosed in adult age. It usually presents as severe constipation with colonic dilatation proximal to the aganglionic segment. Read More

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http://dx.doi.org/10.17235/reed.2016.3841/2015DOI Listing
November 2016
8 Reads

Cancer Immunotherapy with Anti-CTLA-4 Monoclonal Antibodies Induces an Inflammatory Bowel Disease.

J Crohns Colitis 2016 Apr 18;10(4):395-401. Epub 2016 Jan 18.

Department of Gastroenterology, Kremlin Bicêtre Hospital, Assistance publique-Hôpitaux de Paris (AP-HP), Paris Sud University, Le Kremlin Bicêtre, France

Background: Therapeutic monoclonal anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) antibodies are associated with immune-mediated enterocolitis. The aim of this study was to provide a detailed description of this entity.

Methods: We included patients with endoscopic signs of inflammation after anti-CTLA-4 infusions for cancer treatment. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjv227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946758PMC
April 2016
7 Reads

Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?

Redox Biol 2015 Dec 23;6:617-39. Epub 2015 Oct 23.

Instituto de Química e Biotecnologia (IQB), Universidade Federal de Alagoas (UFAL), Brazil. Electronic address:

Oxidative stress (OS) is considered as one of the etiologic factors involved in several signals and symptoms of inflammatory bowel diseases (IBD) that include diarrhea, toxic megacolon and abdominal pain. This systematic review discusses approaches, challenges and perspectives into the use of nontraditional antioxidant therapy on IBD, including natural and synthetic compounds in both human and animal models. One hundred and thirty four papers were identified, of which only four were evaluated in humans. Read More

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http://dx.doi.org/10.1016/j.redox.2015.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637335PMC
December 2015
8 Reads

The burden of Chagas disease: estimates and challenges.

Glob Heart 2015 Sep;10(3):139-44

Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA; Division of Cardiology, University of Washington, Seattle, WA, USA.

Chagas disease, caused by infection with the protozoa Trypanosoma cruzi is transmitted most often by Triatominae insect vectors, but also through blood transfusion, organ transplant, and congenital transmission. Between 5 and 18 million people are currently infected and the infection is estimated to cause more than 10,000 deaths annually. The disease has 3 phases: acute, indeterminate, and chronic. Read More

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http://dx.doi.org/10.1016/j.gheart.2015.06.001DOI Listing
September 2015
3 Reads

[Acute colonic pseudo-obstruction: Ogilvie syndrome].

Authors:
J Keller P Layer

Med Klin Intensivmed Notfmed 2015 Oct 23;110(7):506-9. Epub 2015 Sep 23.

Medizinische Klinik, Israelitisches Krankenhaus, Orchideenstieg 14, 22297, Hamburg, Deutschland.

Acute colonic pseudo-obstruction (ACPO) is characterized by marked colonic dilatation which develops over several days. ACPO is due to a motility disorder and is not caused by colonic obstruction and occurs in patients with severe, often acute underlying diseases or postoperatively. It is associated with a 25-30% mortality overall that increases to up to 50% in patients who develop complications (e. Read More

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http://dx.doi.org/10.1007/s00063-015-0081-4DOI Listing
October 2015
5 Reads

Surgical and medical treatment in patients with acute severe ulcerative colitis.

J Dig Dis 2015 Oct;16(10):558-67

University of Genoa, Department of Surgery, IRCCS Azienda Ospedaliera Universitaria San Martino, Istituto Nazionale per la Ricerca sul Cancro, Italy.

Ulcerative colitis (UC) is a chronic inflammatory disease of the mucosa of the colorectum. The treatment of UC depends on the severity of symptoms and the extent of the disease. Acute severe colitis (ASC) occurs in 12-25% of patients with UC. Read More

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http://dx.doi.org/10.1111/1751-2980.12278DOI Listing
October 2015
13 Reads
3 Citations
1.924 Impact Factor

Mouse model of endoscopically ablated enteric nervous system.

J Surg Res 2016 Jan 28;200(1):117-21. Epub 2015 Jul 28.

Department of Surgery, UCLA David Geffen School of Medicine, Los Angeles, California. Electronic address:

Background: Current transgenic animal models of Hirschsprung disease are restricted by limited survival and need for special dietary care. We used small animal colonoscopy to produce chemically ablated enteric nervous system in the distal colon and rectum of normal mice.

Materials And Methods: Adult C57BL/6 mice underwent colonoscopy with submucosal injection of 75-100 μL of saline (n = 2) or 0. Read More

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http://dx.doi.org/10.1016/j.jss.2015.07.034DOI Listing
January 2016
11 Reads
2 Citations
1.940 Impact Factor

Abdominal X-ray in Pediatric Acute Severe Colitis and Radiographic Predictors of Response to Intravenous Steroids.

J Pediatr Gastroenterol Nutr 2016 Feb;62(2):259-63

*Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center †Hebrew University of Jerusalem, Jerusalem, Israel ‡Alder Hey Children's NHS Foundation Trust, Liverpool, UK §Children's Hospital of Eastern Ontario IBD Centre ||Department of Pediatrics, University of Ottawa, Ottawa, Canada ¶Connecticut Children's Medical Center, Hartford, CT #Nationwide Children's Hospital, Ohio State University, Columbus **SickKids Hospital, University of Toronto, Toronto, Canada.

Background: Abdominal x-ray (AXR) can identify complications in acute severe colitis (ASC) and may assist in selecting high-risk children for early aggressive treatment. We aimed to describe AXR findings in pediatric ASC and to explore radiological predictors of response to intravenous corticosteroid (IVCS) therapy.

Methods: A total of 56 children with ASC were included in a multicenter, retrospective 1-year cohort study (41% boys, mean age 12. Read More

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MPG.0000000000000910DOI Listing
February 2016
23 Reads

[Phosphate Intoxication after Application of Enema--a Life-threatening Iatrogenic Complication].

Klin Padiatr 2015 Jul 3;227(4):235-8. Epub 2015 Jun 3.

Introduction: Enemas are used in pediatric patients with constipation. Retention of phosphate containing enemas with prolonged resorption or reduced renal elimination of phosphate can result in life-threatening hyperphosphatemia with subsequent lethal hypocalcemia and acidosis.

Case Presentation: We report the case of a 6-month-old child who received phosphate-containing enema to treat acute aggravation of constipation. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0035-1548839
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http://dx.doi.org/10.1055/s-0035-1548839DOI Listing
July 2015
3 Reads

Acute colonic pseudoobstruction.

Clin Colon Rectal Surg 2015 Jun;28(2):112-7

Colorectal Surgery Program, Department of Surgery, MedStar Georgetown University Hospital, Washington, District of Columbia ; Section of Colon and Rectal Surgery, Washington Hospital Center, Washington, District of Columbia.

Acute colonic pseudoobstruction (ACPO), often referred to as Ogilvie syndrome, is a clinical entity characterized by severe colonic distension (adult acute megacolon) in the absence of mechanical obstruction. It can result in abdominal ischemia and perforation if left untreated. This article discusses the epidemiology and current pathophysiologic theories of ACPO as well as the clinical presentation and diagnostic modalities utilized to identify the disease. Read More

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http://dx.doi.org/10.1055/s-0035-1549100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442725PMC
June 2015
8 Reads

Toxic megacolon during pregnancy in ulcerative colitis: A case report.

Int J Surg Case Rep 2015 29;11:83-86. Epub 2015 Apr 29.

Florida Hospital Division of Colon and Rectal Surgery,Orlando, FL, USA.

Introduction: Ulcerative colitis is an idiopathic inflammatory bowel condition whose peak incidence coincides with fertility in female patients. In pregnancy, acute fulminant colitis is rare, and, when it becomes refractory to maximum medical therapy, emergency colectomy is mandated. Over the past quarter century, there have been few reports of this rare event in the literature. Read More

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http://dx.doi.org/10.1016/j.ijscr.2015.04.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446693PMC
May 2015
4 Reads

[Motility disorders of the colon].

Internist (Berl) 2015 Jun;56(6):648-52

Abteilung Innere Medizin, Park-Klinik Weissensee, Lehrkrankenhaus der Charité - Universitätsmedizin Berlin, Schönstr. 80, 13086, Berlin, Deutschland,

The motility of the colon is modulated by the enteric nervous system. It is very complex, governing backward and forward movements of the feces. Primary megacolon and megarectum are clinically diverse. Read More

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http://dx.doi.org/10.1007/s00108-014-3607-6DOI Listing
June 2015
4 Reads

[A neonate with aganglionosis of the entire colon].

Ned Tijdschr Geneeskd 2015 ;159:A8733

Universitair Medisch Centrum Groningen, afd. Kinderchirurgie, Groningen.

Background: 1 in every 5,000 children is born with Hirschsprung's disease (HD). Total colonic aganglionosis is an extended form of HD and is present in 2-13% of all patients with the disease.

Case Description: Paediatricians from a general hospital referred a 12-day-old male neonate on account of suspected abdominal obstruction and sepsis. Read More

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October 2015
23 Reads

Toxic megacolon and human Cytomegalovirus in a series of severe ulcerative colitis patients.

J Clin Virol 2015 May 14;66:103-6. Epub 2015 Mar 14.

Biomedical Department of Internal and Specialist Medicine (DIBIMIS), Division of Medicine, Villa Sofia-V. Cervello Hospital, Palermo University, Palermo, Italy. Electronic address:

Background: Human Cytomegalovirus (HCMV) infection has been reported to be a cause of refractory ulcerative colitis (UC). Toxic megacolon (TM) is a rare but severe complication of an acute attack of UC.

Objectives: Aim of this study is to evaluate in a case-control study the association between HCMV and TM. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13866532150008
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http://dx.doi.org/10.1016/j.jcv.2015.03.009DOI Listing
May 2015
10 Reads

Severe hypercalcaemia and colon ischaemia: dehydration as an unusual cause?

BMJ Case Rep 2015 Mar 25;2015. Epub 2015 Mar 25.

Intensive Care Department, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal.

Hypercalcaemia is an emergency with severe consequences. Dehydration can be an uncommon cause of hypercalcaemia, as seen in this case. A 63-year-old woman with type 2 diabetes mellitus, hypothyroidism and osteoporosis, was admitted to the emergency room with abdominal distension and vomiting for 24 h. Read More

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http://dx.doi.org/10.1136/bcr-2014-208809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386446PMC
March 2015
6 Reads

Giant colonic volvulus due to colonic pseudo-obstruction.

BMJ Case Rep 2015 Feb 25;2015. Epub 2015 Feb 25.

Department of General Surgery, Izmir Tepecik Teaching and Research Hospital, Izmir, Turkey.

Acute colonic pseudo-obstruction (ACPO), also known as Ogilvie's syndrome, is a clinical syndrome characterised by gross dilation of the caecum and right hemicolon, which sometimes extends to the sigmoid colon and rectum in the absence of an anatomic lesion in the intestinal lumen. It is characterised by impaired propulsion of contents of the gastrointestinal tract, which results in a clinical picture of intestinal obstruction. A careful examination of the markedly distended colon can exclude several colonic pathologies, including mechanical obstruction and other causes of toxic megacolon. Read More

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http://dx.doi.org/10.1136/bcr-2014-207963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342665PMC
February 2015
6 Reads

Mast cells in the colon of Trypanosoma cruzi-infected patients: are they involved in the recruitment, survival and/or activation of eosinophils?

Parasitol Res 2015 May 25;114(5):1847-56. Epub 2015 Feb 25.

Departamento de Morfologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, 31.270-901, Brazil.

Megacolon is frequently observed in patients who develop the digestive form of Chagas disease. It is characterized by dilation of the rectum-sigmoid portion and thickening of the colon wall. Microscopically, the affected organ presents denervation, which has been considered as consequence of an inflammatory process that begins at the acute phase and persists in the chronic phase of infection. Read More

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http://link.springer.com/content/pdf/10.1007%2Fs00436-015-43
Web Search
http://link.springer.com/10.1007/s00436-015-4371-9
Publisher Site
http://dx.doi.org/10.1007/s00436-015-4371-9DOI Listing
May 2015
11 Reads