7,934 results match your criteria Megacolon Acute


Scintigraphic evaluation of colonic transit in children with constipation using Ga-citrate.

World J Nucl Med 2018 Oct-Dec;17(4):249-252

Hospital de Base do Distrito Federal - Nuclear Medicine Service, Brasília, Brasil.

The aim of this study was to assess the colonic transit in children and teenagers with chronic constipation. Twenty patients from 1.5 to 16 years old were included (mean age = 6. Read More

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December 2018

Bacteremia by Leuconostoc mesenteroides in an immunocompetent patient with chronic Chagas disease: a case report.

BMC Infect Dis 2018 Nov 3;18(1):547. Epub 2018 Nov 3.

Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes, s/n - Monte Alegre, Ribeirão Preto, SP, 14049-900, Brazil.

Background: The Leuconostoc mesenteroides are members of the Streptococcae family and currently has been recognized as potential pathogens. This case describes a bacteremia caused by L. mesenteroides in an immunocompetent patient affected by Chagas disease. Read More

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November 2018
3 Reads

H, C and N resonance assignments and structure prediction of translation initiation factor 1 from Clostridium difficile.

Biomol NMR Assign 2018 Oct 28. Epub 2018 Oct 28.

Department of Chemistry, The University of Texas Rio Grande Valley, Edinburg, TX, USA.

Clostridium difficile is a gram-positive, toxin-producing, anaerobic bacterium whose virulence factors and mechanisms of pathogenesis require further investigation. C. difficile infections (CDI) result in the severe and potentially fatal gastrointestinal diseases pseudomembranous colitis and toxic megacolon following extensive broad spectrum antibiotic treatment. Read More

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October 2018
4 Reads

Diagnosis and Treatment of Invasive Aspergillus fumigatus Wound Infection Following Subtotal Colectomy for Perforated Toxic Megacolon in an Immunosuppressed Patient.

Wounds 2018 Oct;30(10):E102-E104

Department of Surgery, Swedish Medical Center, Seattle, WA.

Introduction: Aspergillus is a rare cause of surgical site infection most often seen in immunocompromised patients undergoing cardiac, transplant, ophthalmologic, or burn operations; an unusual case following a colon resection is presented here.

Case Report: The authors report a case of an invasive Aspergillus fumigatus infection following a subtotal colectomy for toxic megacolon. The patient was on antibiotics following the operation and chronic immunosuppression with steroids and infliximab. Read More

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October 2018
3 Reads

Lower urinary tract dysfunction in chronic Chagas disease: clinical and urodynamic presentation.

World J Urol 2018 Oct 9. Epub 2018 Oct 9.

Intertryp, IRD-Cirad, Université de Montpellier, Montpellier, France.

Purpose: To describe and give an estimation of the prevalence of urinary disorders in chronic Chagas disease, since most clinical research has been centered on the description of the cardiac and digestive forms.

Methods: To explore this topic, a cross-sectional study was conducted in 137 Bolivian adults of both sexes suffering from symptomatic chronic Chagas disease. All patients presenting confirmed chagasic cardiomyopathy, megacolon or both underwent a urologic symptom questionnaire, uroflowmetry, urinary tract ultrasonography and a creatinine assay. Read More

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October 2018
5 Reads

Imaging features of toxic megacolon.

BMJ Case Rep 2018 Sep 30;2018. Epub 2018 Sep 30.

Department of Diagnostic Imaging, Hospital Tuanku Ja'afar Seremban, Seremban, Malaysia.

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September 2018
2 Reads

Evaluation of risk factors for a fulminant Clostridium difficile infection after cardiac surgery: a single-center, retrospective cohort study.

BMC Anesthesiol 2018 Sep 27;18(1):133. Epub 2018 Sep 27.

University Department for Cardiac Surgery, Heart Center Leipzig, Struempellstr. 39, 04289, Leipzig, Germany.

Background: Clostridium difficile (CD) is the most common pathogen causing nosocomial diarrhea. The clinical presentation ranges from mild diarrhea to severe complications, including pseudomembranous colitis, toxic megacolon, sepsis, and multi-organ failure. When the disease takes a fulminant course, death ensues rapidly in severe and complex cases. Read More

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September 2018
1 Read

Mouse Gamma Herpesvirus MHV-68 Induces Severe Gastrointestinal (GI) Dilatation in Interferon Gamma Receptor-Deficient Mice (IFNγR) That Is Blocked by Interleukin-10.

Viruses 2018 09 23;10(10). Epub 2018 Sep 23.

Department of Medicine, Divisions of Cardiovascular Medicine and Rheumatology, University of Florida, Gainesville, FL 32610-0277, USA.

Inflammatory bowel disease (IBD) and infection cause gastrointestinal (GI) distension and, in severe cases, toxic megacolon with risk of perforation and death. Herpesviruses have been linked to severe GI dilatation. MHV-68 is a model for human gamma herpesvirus infection inducing GI dilatation in interleukin-10 (IL-10)-deficient mice but is benign in wildtype mice. Read More

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September 2018
1 Read

Atypical onset of total colonic Hirschsprung disease in a small female infant: A case report.

Medicine (Baltimore) 2018 Sep;97(38):e12315

University of Medicine and Pharmacy of Tirgu Mures, Tirgu Mures, Romania.

Rationale: Hirschsprung disease (HD) or colonic aganglionosis is a congenital disorder, which results from the abnormal migration of neuronal cells of the neural crest leading to a disorder of the enteric nervous system consisting in the absence of ganglion cells within the submucosal and myenteric plexus.

Patient Concerns: We report the case of a 7-month-old female infant admitted in our clinic for constipation and failure to thrive. At the age of 6 months, she was examined in our clinic for the same reasons, and we recommended symptomatic treatment without improvements. Read More

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September 2018
1 Read
5.720 Impact Factor

Phospho-proteomic analysis of primary human colon epithelial cells during the early Trypanosoma cruzi infection phase.

PLoS Negl Trop Dis 2018 Sep 17;12(9):e0006792. Epub 2018 Sep 17.

Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee, United States of America.

The protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease, causes severe morbidity and mortality in afflicted individuals. About 30% of T. cruzi-infected individuals present with cardiac, gastrointestinal tract, and/or neurological disorders. Read More

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September 2018
4 Reads

The Skiles Mummy: Care of a debilitated hunter-gatherer evidenced by coprolite studies and stable isotopic analysis of hair.

Int J Paleopathol 2018 Sep 7. Epub 2018 Sep 7.

University of Nebraska-Lincoln, School of Natural Resources, United States.

The Skiles Mummy (SMM), a naturally mummified adult male from the late archaic period of Lower Pecos Canyonlands of South Texas, represents a unique case of care. SMM is an exceptional mummy within this region due to both the retention of a full head of hair, and having a diagnosed case of megacolon, a complication commonly associated with Chagas disease caused by Trypanosoma cruzi. Stable isotopic analysis of his hair is consistent with a diet incorporating of C/CAM plants with some C plants, freshwater resources, and higher trophic level animals. Read More

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September 2018
5 Reads

Megabowel and Giant Fecaloma: a Surgical Condition?

J Gastrointest Surg 2018 Sep 4. Epub 2018 Sep 4.

Department of Surgery, Traumatology and Acute Care, Hôpital du Sacré-Coeur de Montréal, Montreal, Québec, Canada.

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September 2018
9 Reads

First reported case of afatinib-associated toxic megacolon.

Respirol Case Rep 2018 Oct 31;6(7):e00360. Epub 2018 Aug 31.

Department of Medicine Queen Mary Hospital Hong Kong China.

We report the first case of toxic megacolon associated with afatinib use, which is a potentially fatal complication, with risks of colonic perforation. In this case, the condition improved on stopping afatnib. Clinicians need to be alert of this rare but fatal adverse effect and to avoid anti-diarrhoeal agents, which can worsen toxic megacolon. Read More

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October 2018
1 Read

Variable spectrum of disease and risk factors of peripartum Clostridium difficile infection: report of 14 cases from French hospitals and literature review.

Eur J Clin Microbiol Infect Dis 2018 Dec 3;37(12):2293-2299. Epub 2018 Sep 3.

Service de Biologie, Unité de Microbiologie, Centre Hospitalier de Versailles, Le Chesnay, France.

Our aim was to study Clostridium difficile infection (CDI) in peripartum women in France and compare them to cases published in the literature. We characterize these infections regarding clinico-biological features and specific risk factors in order to raise awareness for obstetricians and midwifes. Eight antepartum and six post-partum CDI cases were retrospectively studied in 6 French centers during the period between 2008 and 2013. Read More

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December 2018
4 Reads

Digital pathology imaging and computer-aided diagnostics as a novel tool for standardization of evaluation of aganglionic megacolon (Hirschsprung disease) histopathology.

Cell Tissue Res 2018 Sep 3. Epub 2018 Sep 3.

Institute of Anatomy and Cell Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstraße 9, 91054, Erlangen, Germany.

Based on a recently introduced immunohistochemical panel (Bachmann et al. 2015) for aganglionic megacolon (AM), also known as Hirschsprung disease, histopathological diagnosis, we evaluated whether the use of digital pathology and 'machine learning' could help to obtain a reliable diagnosis. Slides were obtained from 31 specimens of 27 patients immunohistochemically stained for MAP2, calretinin, S100β and GLUT1. Read More

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September 2018
1 Read

colitis and zoonotic origins-a narrative review.

Gastroenterol Rep (Oxf) 2018 Aug 28;6(3):157-166. Epub 2018 Jun 28.

General Surgery Department, Liverpool Hospital, Elizabeth St, Liverpool, NSW, Australia.

is a major cause of hospital-associated diarrhoea, and in severe cases leads to pseudomembranous colitis and toxic megacolon. The frequency of infection (CDI) has increased in recent decades, with 453 000 cases identified in 2011 in the USA. This is related to antibiotic-selection pressure, disruption of normal host intestinal microbiota and emergence of antibiotic-resistant strains. Read More

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August 2018
9 Reads

The Reality of Multiple Endocrine Neoplasia Type 2B Diagnosis: Awareness of Unique Physical Appearance Is Important.

J Nippon Med Sch 2018 ;85(3):178-182

Department of Endocrine Surgery, Nippon Medical School.

Background: Multiple endocrine neoplasia type 2B (MEN2B) is an extremely rare syndrome mainly caused by RET918 germline mutations. MEN2B typically causes medullary thyroid carcinoma (MTC), pheochromocytoma, and unique physical characteristics including mucosal neuroma, distinctive facial appearance, and Marfanoid habitus. Most patients have abdominal symptoms such as bloating, intermittent constipation, and diarrhea. Read More

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October 2018
2 Reads

Prevalence and Strain Characterization of in Representative Regions of Germany, Ghana, Tanzania and Indonesia - A Comparative Multi-Center Cross-Sectional Study.

Front Microbiol 2018 7;9:1843. Epub 2018 Aug 7.

Institute of Medical Microbiology, University Medical Center Göttingen Göttingen, Germany.

infections (CDI) are considered worldwide as emerging health threat. Uptake of spores may result in asymptomatic carrier status or lead to CDI that could range from mild diarrhea, eventually developing into pseudomembranous colitis up to a toxic megacolon that often results in high mortality. Most epidemiological studies to date have been performed in middle- and high income countries. Read More

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August 2018
2 Reads

Bowel perforation in chronic idiopathic megarectum and megacolon.

BMJ Case Rep 2018 Aug 20;2018. Epub 2018 Aug 20.

General Surgery, Newham University Hospital, London, UK.

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August 2018
2 Reads

Outcomes of Clostridium difficile-suspected diarrhea in a French university hospital.

Eur J Clin Microbiol Infect Dis 2018 Nov 17;37(11):2123-2130. Epub 2018 Aug 17.

Sanofi Pasteur, Lyon, France.

Clostridium difficile infection (CDI) produces a variety of clinical presentations ranging from mild diarrhea to severe infection with fulminant colitis, septic shock, and death. CDI puts a heavy burden on healthcare systems due to increased morbidity and mortality, and higher costs. We evaluated the clinical impact of CDI in terms of complications and mortality in a French university hospital compared with patients with diarrhea unrelated to CDI. Read More

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November 2018
14 Reads

Surgical treatment of children with total colonic aganglionosis: functional and metabolic long-term outcome.

BMC Surg 2018 Aug 15;18(1):58. Epub 2018 Aug 15.

Department of Pediatric Surgery and Pediatric Urology, University Children's Hospital of Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

Background: Total colonic aganglionosis (TCA) is a rare variant of Hirschsprung's disease occurring in 3-10% of the cases. Only few studies reported the long-term clinical and metabolic outcomes of patients with TCA. The aim of this study was to evaluate the functional and metabolic long-term outcomes of children undergoing surgical treatment for TCA. Read More

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August 2018
1 Read

Abdominal compartment syndrome secondary to megarectum and megasigmoid.

BMJ Case Rep 2018 Aug 8;2018. Epub 2018 Aug 8.

Department of Surgery, University Hospital Limerick, Limerick, Ireland.

A 31-year-old male patient with chronic constipation of unknown aetiology presented emergently with worsening nausea, vomiting and abdominal distension of one week duration. On examination, his abdomen was distended with minimal tenderness. A plain film of the abdomen demonstrated severe faecal loading. Read More

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August 2018
8 Reads

Clostridium difficile, the Difficult "Kloster" Fuelled by Antibiotics.

Curr Microbiol 2018 Aug 6. Epub 2018 Aug 6.

Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, 141, Stockholm, Sweden.

Clostridium difficile is normally present in low numbers in a healthy adult gastro-intestinal tract (GIT). Drastic changes in the microbial population, e.g. Read More

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August 2018
11 Reads

In-hospital mortality for toxic megacolon.

Intern Emerg Med 2018 09 2;13(6):837-838. Epub 2018 Aug 2.

Clinica Medica I, Department of Internal Medicine, IRCCS San Matteo Hospital Foundation, University of Pavia, Pavia, 27100, Italy.

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September 2018
4 Reads

HSV1/2 Genital Infection in Mice Cause Reversible Delayed Gastrointestinal Transit: A Model for Enteric Myopathy.

Front Med (Lausanne) 2018 17;5:176. Epub 2018 Jul 17.

All India Institute of Medical Sciences, New Delhi, India.

In an interesting investigation by Khoury-Hanold et al. (1), genital infection of mice with herpes simplex virus 1 (HSV1) were reported to cause multiple pelvic organ involvement and obstruction. A small subset of mice succumbed after the first week of HSV1 infection. Read More

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July 2018
3 Reads

Pulmonary Involvement in Crohn's Disease: A Rare Case Report.

Cureus 2018 May 30;10(5):e2710. Epub 2018 May 30.

Graduate, Pontifical Catholic University of Ecuador, Chagrin Falls, USA.

Crohn's disease (CD) is a granulomatous inflammatory disease that can involve any part of the gastrointestinal tract, from mouth to anus. In most cases, it remits and relapses in the terminal ileum, requiring treatment via steroid boluses. In rare cases, however, CD can involve the pulmonary system presenting as dyspnea on exertion and dry cough. Read More

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May 2018
4 Reads

Long non-coding RNA FAL1 functions as a ceRNA to antagonize the effect of miR-637 on the down-regulation of AKT1 in Hirschsprung's disease.

Cell Prolif 2018 Oct 30;51(5):e12489. Epub 2018 Jul 30.

State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China.

Objectives: Emerged evidence demonstrates that long non-coding RNAs (lncRNAs) may play quintessential regulatory roles in the cellular processes, tumourigenesis and the development of disease. Though focally amplified lncRNA on chromosome 1 (FAL1) has been identified to have crucial functions in many diseases, its biological mechanism in the development of Hirschsprung's disease (HSCR) still remains unknown.

Materials And Methods: The expression levels of FAL1 in HSCR aganglionic tissues and matched normal specimens were detected by quantitative real-time PCR (qRT-PCR). Read More

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October 2018
3 Reads
3.120 Impact Factor

GT-repeat extension in the IL11 promoter is associated with Hirschsprung's disease (HSCR).

Gene 2018 Nov 26;677:163-168. Epub 2018 Jul 26.

Department of Pediatric Surgery, University Hospital Carl Gustav Carus, TU Dresden, Germany.

Hirschsprung's disease (HSCR) is a congenital disease characterized by intestinal obstruction due to a defective intestinal neural system. Frequently, the disease is associated with an intestinal inflammation. The most common known underlying genetic alterations are in the RET gene but HSCR can also be caused by mutations in other genes that are responsible for the maturation and migration of intestinal neural cells. Read More

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November 2018

Symptomatic pulmonary restriction secondary to diaphragmatic eventration and megacolon in adult.

BMJ Case Rep 2018 Jul 26;2018. Epub 2018 Jul 26.

General Surgery, NYU Langone Medical Center, Brooklyn, New York, USA.

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July 2018
1 Read

Association between DSCAM polymorphisms and non-syndromic Hirschsprung disease in Chinese population.

BMC Med Genet 2018 Jul 13;19(1):116. Epub 2018 Jul 13.

Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China.

Background: Hirschsprung disease (HSCR, aganglionic megacolon) is the most frequent genetic cause of congenital intestinal obstruction. DSCAM was identified as associated to HSCR with Down Syndrome (DS-HSCR) in European population,but failed to replicate in the non-syndromic HSCR patients. We aim to further investigate the relationship of DSCAM with non-sydromic HSCR in a South Chinese cohort, the largest case-control study so far. Read More

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July 2018
7 Reads

[Inflammatory bowel disease: cardinal signs and their diagnostics].

Dtsch Med Wochenschr 2018 Jul 4;113(13):937-944. Epub 2018 Jul 4.

Inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, often occur early in life. Therefore, they affect our patient's individual path of life, their ability to work and the quality of life tremendously, which calls for close and comprehensive medical care. This article features 5 cardinal signs and their diagnostics. Read More

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July 2018
4 Reads

Laparoscopic Excision of an Obstructing Soave Cuff in Hirschsprung's Disease.

J Laparoendosc Adv Surg Tech A 2018 Jul 29;28(7):894-898. Epub 2018 Jun 29.

Cardinal Glennon Children's Hospital, Saint Louis University , Saint Louis, Missouri.

Background: The Soave pull-through for Hirschsprung's disease leaves a muscular cuff of aganglionosis surrounding the pull-through. In some patients, this cuff can extrinsically compress the pull-through, leading to chronic enterocolitis and failure to thrive. We describe a novel technique for managing the Soave cuff as an alternative to a complete redo pull-through. Read More

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July 2018
1 Read

Incidental finding of pulmonary arterial sling during patent ductus arteriosus surgery in a patient with Mowat-Wilson syndrome.

Cardiol Young 2018 Aug 29;28(8):1074-1076. Epub 2018 Jun 29.

3Pediatric Interventional Cardiology Department,Fundación Cardioinfantil,Bogotá,Colombia.

Mowat-Wilson syndrome is a genetic condition due to a mutation in the ZEB2 gene; it affects many systems including the cardiovascular system. The pulmonary arterial sling originates from a failure of development of the proximal portion of the left sixth aortic arch, resulting in an anomalous left pulmonary artery origin from the posterior wall of the right pulmonary artery and the left pulmonary artery crossing to the left lung between the trachea and the oesophagus. We present a 4-month-old infant with Mowat-Wilson syndrome and left pulmonary arterial sling, and discuss the association of these two rare conditions. Read More

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August 2018
14 Reads

Incidence, features, in-hospital outcomes and predictors of in-hospital mortality associated with toxic megacolon hospitalizations in the United States.

Intern Emerg Med 2018 Sep 12;13(6):881-887. Epub 2018 Jun 12.

Department of Internal Medicine, HCA GME Consortium's Internal Medicine Program, University of Central Florida College of Medicine, Gainesville, FL, USA.

Toxic megacolon (TM) is a potentially fatal condition characterized by non-obstructive colonic dilatation and systemic toxicity. It is most commonly caused by inflammatory bowel disease (IBD). Limited data for TM are available demonstrating incidence, in-hospital outcomes and predictors of mortality. Read More

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September 2018
2 Reads

[Management of Clostridium difficile infections at German intensive care units - results from a survey among intensivists].

Z Gastroenterol 2018 06 11;56(6):551-560. Epub 2018 Jun 11.

Klinik für Gastroenterologie, Stoffwechselerkrankungen und Internistische Intensivmedizin, Uniklinik RWTH Aachen.

Background: Clostridium difficile associated colitis is a frequent cause of nosocomial diarrhea at the intensive care unit (ICU) and is associated with poor prognosis in critically ill patients. Few studies have evaluated the efficacy of treatment options or adherence to guideline recommendations of Clostridium difficile infections at the ICU.

Methods: Therefore, on behalf of the Gastroenterology Intensive Care Medicine working group of the DGVS, we have conducted an online-based survey among leading intensivists in Germany. Read More

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June 2018
5 Reads

Current updates in management of Clostridium difficile infection in cancer patients.

Curr Med Res Opin 2018 Jul 5:1-6. Epub 2018 Jul 5.

e Department of Hematology & Oncology , St. Luke's Hospital of Kansas City/University of Missouri , Kansas City , MO , USA.

Background: Clostridium difficile infection (CDI) is a significant health burden, now recognized as the leading cause of acquired diarrhea in patients receiving antibiotic therapy. Complications of infection with this pathogen include severe diarrhea, causing electrolyte imbalances, dehydration, hemodynamic instability, toxic megacolon, shock, and death. Hence it is extremely paramount to stay updated on management options for this infection, especially in cancer patients. Read More

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July 2018
1 Read

Japanese clinical practice guidelines for allied disorders of Hirschsprung's disease, 2017.

Pediatr Int 2018 May;60(5):400-410

The guideline establishment group for allied disorders of Hirschsprung's disease, Science Research, Ministry of Health Labour and Welfare, Fukuoka, Japan.

Background: Despite the presence of ganglion cells in the rectum, some patients have symptoms similar to those of Hirschsprung's disease. A consensus has yet to be established regarding the terminology for these diseases. We defined this group of diseases as "allied disorders of Hirschsprung's disease" and compiled these guidelines to facilitate accurate clinician diagnosis and provide appropriate treatment strategies for each disease. Read More

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May 2018
20 Reads

Clinical practice guidelines for allied disorders of Hirschsprung's disease.

Authors:
Jun Murakami

Pediatr Int 2018 05;60(5):399

Division of Pediatrics and Perinatology, Tottori University Faculty of Medicine, Yonago, Japan.

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infection and antibiotic-associated diarrhoea.

Clin Med (Lond) 2018 Jun;18(3):237-241

St Mary's Hospital Campus, Imperial College London, London, UK.

Antibiotic-associated diarrhoea is among the most common adverse events related to antibiotic use. Most cases are mild, but infection causes a spectrum of disease, ranging from occasional diarrhoea to colitis, toxic megacolon, and potentially death. Recent developments in our understanding of the biology of the gut microbiota have provided new insights into the pathogenesis of these conditions, and have revealed a role for manipulation of the gut microbiota as a novel therapeutic approach. Read More

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June 2018
2 Reads

Enteric Neural Stem Cells Expressing Insulin-Like Growth Factor 1: A Novel Cellular Therapy for Hirschsprung's Disease in Mouse Model.

DNA Cell Biol 2018 Jul 24;37(7):642-648. Epub 2018 May 24.

Department of Pediatric Surgery, Shandong Provincial Hospital Affiliated to Shandong University , Jinan, China .

Transplanting enteric neural stem cells (ENSCs) is an innovative approach for replacing enteric neurons in Hirschsprung's disease (HSCR). However, posttransplantation cell survival and differentiation limit efficacy. We aimed to investigate whether transplantation of ENSCs engineered with insulin-like growth factor 1 (IGF-1) could improve survival and differentiation of the engrafted cells and promote functional recovery of the aganglionic colon. Read More

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July 2018
2 Reads

Congenital diaphragmatic disease: An unusual presentation in adulthood. Case report.

Int J Surg Case Rep 2018 7;48:34-37. Epub 2018 May 7.

Department of Biomedical Sciences and Human Oncology, Unit of Endocrine, Digestive and Emergency Surgery, University Medical School "A. Moro'', Bari, Italy.

Introduction: Congenital diaphragmatic disease is a quite common condition that usually occurs in the neonatal period, and the diagnosis of congenital diaphragmatic disease in adulthood is rare.

Case Presentation: A 64-years-old Caucasian woman was admitted in emergency at our Department, due to a bowel obstruction and dyspnea. A CT-scan showed a diaphragmatic herniation in the left area, with malposition of dilated transverse and descending colon in the chest. Read More

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May 2018
3 Reads

Bis-Cyclic Guanidines as a Novel Class of Compounds Potent against Clostridium difficile.

ChemMedChem 2018 Jul 14;13(14):1414-1420. Epub 2018 Jun 14.

Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, Tampa, FL, 33620, USA.

Clostridium difficile infection (CDI) symptoms range from diarrhea to severe toxic megacolon and even death. Due to its rapid acquisition of resistance, C. difficile is listed as an urgent antibiotic-resistant threat, and has surpassed methicillin-resistant Staphylococcus aureus (MRSA) as the most common hospital-acquired infection in the USA. Read More

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July 2018
1 Read
2.970 Impact Factor

[Syndromic Hirschsprung′s disease and its mode of inheritance].

Zhongguo Dang Dai Er Ke Za Zhi 2018 May;20(5):428-432

Department of Neonatal Surgery, Shengjing Hospital of China Medical University, Shenyang 110003, China.

Hirschsprung′s disease (HSCR) is one of the major causes of chronic incomplete intestinal obstruction in children. HSCR is considered a type of neurocristopathy caused by no colonization of ganglion cells on some parts of the bowel wall due to abnormal termination of the migration of vagal neural cells during embryonic development. This disease can be classified into different types according to the length of the affected intestinal canal. Read More

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May 2018
4 Reads

A Rare Case of Adult-Onset Rectosigmoid Hypoganglionosis.

Am J Case Rep 2018 May 14;19:557-561. Epub 2018 May 14.

Department of General Surgery, Colorectal Surgery Section, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

BACKGROUND Intestinal hypoganglionosis is very rare and accounts for 3% to 5% of all classified congenital intestinal innervation disorders. Isolated hypoganglionosis of the colon is a particularly rare form of the disease, and differential diagnosis includes association with Hirschsprung's disease and chronic intestinal pseudo-obstruction (CIPO) related to visceral myopathies. Most cases are diagnosed at an early age or in childhood with only a few cases reported in adults. Read More

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May 2018
1 Read

Cartilage hair hypoplasia with cutaneous lymphomatoid granulomatosis.

Clin Exp Dermatol 2018 Aug 10;43(6):713-717. Epub 2018 May 10.

Department of Pathology, Birmingham Children's Hospital, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.

Cartilage-hair hypoplasia (CHH) is an autosomal recessive chondrodysplasia characterized by short-stature, sparse hair and impaired cellular immunity. We describe a young girl who was diagnosed with CHH based on the findings of recurrent infections, short stature with metaphyseal chondrodysplasia, and a confirmed bi-allelic RMRP gene mutation. At 13 years, the patient developed an Epstein-Barr virus (EBV)-driven lymphoproliferative disorder involving the lung, which responded partially to chemotherapy. Read More

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August 2018
1 Read

Functional outcomes in Hirschsprung disease patients after transabdominal Soave and Duhamel procedures.

BMC Gastroenterol 2018 Apr 27;18(1):56. Epub 2018 Apr 27.

Pediatric Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Gadjah Mada/Dr. Sardjito Hospital, Jl. Kesehatan No. 1, Yogyakarta, 55281, Indonesia.

Background: Several pull-through procedures have been described for Hirschsprung disease (HSCR) with varying functional outcomes. The voluntary bowel movement (VBM) and the absence of soiling or constipation after pull-through remain the most important markers of good outcome. We aimed to compare the functional outcomes in HSCR patients following Soave and Duhamel procedures. Read More

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April 2018
8 Reads

- From Colonization to Infection.

Front Microbiol 2018 10;9:646. Epub 2018 Apr 10.

Extracorporeal Immunomodulation Unit, Fraunhofer Institute for Cell Therapy and Immunology, Rostock, Germany.

is the most frequent cause of nosocomial antibiotic-associated diarrhea. The incidence of infection (CDI) has been rising worldwide with subsequent increases in morbidity, mortality, and health care costs. Asymptomatic colonization with is common and a high prevalence has been found in specific cohorts, e. Read More

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April 2018
2 Reads

Serum vancomycin concentrations after oral and intracolonic vancomycin administration in a patient with colonic discontinuity and severe infection.

Am J Health Syst Pharm 2018 May;75(9):e189-e193

Division of Infectious Diseases, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany

Purpose: A case of detectable systemic vancomycin levels after oral vancomycin administration but not after intracolonic administration in a patient with colonic discontinuity and severe infection (CDI) is reported.

Summary: A 63-year-old woman who had recently undergone pancreas-kidney transplantation developed severe CDI after 13 days of meropenem therapy for presumed urosepsis. Meropenem was stopped immediately, and treatment with oral vancomycin (250 mg every 6 hours) was started. Read More

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May 2018
3 Reads