Radiology 2022 Apr 19:212137. Epub 2022 Apr 19.
From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, Stanford University, 725 Welch Rd, G516, Palo Alto, CA 94304; Department of Statistics, Stanford University, Stanford, Calif (S.W.W.); Department of Radiology (J.N.W.) and Division of Pediatric Hematology/Oncology, Department of Pediatrics (N.A.V.), Seattle Children's Hospital, Seattle, Wash; Department of Radiology, Harborview Medical Center, Seattle, Wash (J.N.W.); Departments of Diagnostic Imaging (M.W.W., S. Laughlin, B.E.W.) and Surgery (M.T.) and Division of Haematology/Oncology, Department of Pediatrics (V.R.), The Hospital for Sick Children, Toronto, Canada; Departments of Neurosurgery (S.T., K.A.), Radiology (K.M.), and Developmental Biology & Cancer (T.S.J.), Great Ormond Street Institute of Child Health, London, UK; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pa (M.H.); Stanford School of Medicine, Stanford University, Stanford, Calif (L.T.T.); Departments of Radiology (K.S., M.M.) and Neurosurgery (S.H.), Duke Children's Hospital & Health Center, Durham, NC; Department of Physiology and Nutrition, University of Colorado-Colorado Springs, Colorado Springs, Colo (S. Lummus); Department of Radiology, Children's Hospital of Orange County, Orange, Calif (H.L., A.E.); Department of Radiology, New York University Grossman School of Medicine, New York, NY (A.R.); Division of Pediatric Neurosurgery, Department of Neurosurgery, and Huntsman Cancer Institute, University of Utah School of Medicine, Intermountain Healthcare Primary Children's Hospital, Salt Lake City, Utah (J.N., S.H.C., E.T.); Division of Child Neurology, Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montreal, Canada (S. Perreault); Department of Clinical Radiology & Imaging Sciences, Riley Children's Hospital, Indianapolis, Ind (K.R.M.B., C.Y.H.); Division of Neurosurgery, Dayton Children's Hospital, Dayton, Ohio (R.M.L.); Department of Pediatrics, Doernbecher Children's Hospital, Portland, Ore (Y.J.C.); Department of Radiology, Boston Children's Hospital, Boston, Mass (T.P.); Department of Pediatrics, Hopp Children's Cancer Center, Heidelberg, Germany (S. Pfister); and Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill (A.J.).
Background Radiogenomics of pediatric medulloblastoma (MB) offers an opportunity for MB risk stratification, which may aid therapeutic decision making, family counseling, and selection of patient groups suitable for targeted genetic analysis. Purpose To develop machine learning strategies that identify the four clinically significant MB molecular subgroups. Materials and Methods In this retrospective study, consecutive pediatric patients with newly diagnosed MB at MRI at 12 international pediatric sites between July 1997 and May 2020 were identified. Read More