616 results match your criteria Medullary Sponge Kidney


[Ultrasound screening and follow-up study of congenital anomalies of the kidney and urinary tract in neonates].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Dec;51(6):1062-1066

Department of Ultrasound, Beijing Tsinghua Changgung Hospital Affiliated to Tsinghua University, Beijing 102218, China.

Objective: To investigate the incidence of congenital anomalies of the kidney and urinary tract (CAKUT) in neonates, and to evaluate the value of urinary ultrasound screening in the early postnatal period.

Methods: The neonates born or treated in Beijing Tsinghua Changgung Hospital affiliated to Tsinghua University between January 2016 and December 2018 accepted the urinary ultrasound screening, and the neonates with problem were followed up. In the meanwhile, the maternal pregnancy data were analyzed to screen out the risk factors associated with the onset of CAKUT. Read More

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December 2019

Proteomic Analysis of Urinary Extracellular Vesicles Reveals a Role for the Complement System in Medullary Sponge Kidney Disease.

Int J Mol Sci 2019 Nov 5;20(21). Epub 2019 Nov 5.

Renal Unit, Department of Medicine, University/Hospital of Verona, Piazzale A. Stefani 1, 37126 Verona, Italy.

Medullary sponge kidney (MSK) disease is a rare and neglected kidney condition often associated with nephrocalcinosis/nephrolithiasis and cystic anomalies in the precalyceal ducts. Little is known about the pathogenesis of this disease, so we addressed the knowledge gap using a proteomics approach. The protein content of microvesicles/exosomes isolated from urine of 15 MSK and 15 idiopathic calcium nephrolithiasis (ICN) patients was investigated by mass spectrometry, followed by weighted gene coexpression network analysis, support vector machine (SVM) learning, and partial least squares discriminant analysis (PLS-DA) to select the most discriminative proteins. Read More

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http://dx.doi.org/10.3390/ijms20215517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862015PMC
November 2019
1 Read

Medullary Sponge Kidney: Current Perspectives.

Int J Nephrol Renovasc Dis 2019 26;12:213-218. Epub 2019 Sep 26.

Department of Medicine, Division of Pulmonary Critical Care and Sleep Medicine, Stony Brook University Hospital, Stony Brook, NY, USA.

Medullary Sponge Kidney (MSK) disease is a rare congenital malformation of the distal nephron where cystic dilatation is appreciable in the collecting ducts and renal papillae. Most cases of the malformation are thought to arise from a malfunction within neurotrophic factor and tyrosine kinase interactions. Presentation and prognosis are usually indolent; however, they include urinary tract infections (UTI), nephrolithiasis and nephrocalcinosis, distal renal tubular acidosis (dRTA) and hypocitraturia. Read More

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http://dx.doi.org/10.2147/IJNRD.S169336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769051PMC
September 2019
2 Reads

Phosphate matters when investigating hypercalcemia: a mutation in SLC34A3 causing HHRH

Endocrinol Diabetes Metab Case Rep 2019 Jul 26;2019(1):1-6. Epub 2019 Jul 26.

Division of Endocrinology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada

Summary: Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) is a rare, autosomal recessive disorder caused by mutations in the SLC34A3 gene that encodes the renal sodium-dependent phosphate cotransporter 2c (NaPi-IIc). It may present as intermittent mild hypercalcemia which may attract initial diagnostic attention but appreciation of concomitant hypophosphatemia is critical for consideration of the necessary diagnostic approach. A 21-year-old woman was assessed by adult endocrinology for low bone mass. Read More

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http://dx.doi.org/10.1530/EDM-19-0058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685096PMC
July 2019
4 Reads

The impact of potassium citrate therapy in the natural course of Medullary Sponge Kidney with associated nephrolithiasis.

Arch Ital Urol Androl 2019 Jul 2;91(2). Epub 2019 Jul 2.

Urology Unit, Department of Surgery, Ospedale Ca' Foncello, Treviso.

Objectives: The present study was carried out to evaluate the effectiveness of medical therapy with potassium citrate in preventing calculosis complicating Medullary Sponge Kidney (MSK) without renal acidification defects.

Materials And Methods: In a open, uncontrolled, retrospective analysis, 49 MSK patients with nephrolithiasis without renal tubular acidosis, underwent a complete metabolic evaluation and received potassium citrate therapy 4-6 g/day. The course of stone disease before and after citrate therapy was determined in each patient from a combination of clinical history, past records, radiographs and kidney ultrasound. Read More

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http://dx.doi.org/10.4081/aiua.2019.2.102DOI Listing
July 2019
4 Reads

Trends in surgical management of multicystic dysplastic kidney at USA children's hospitals.

J Pediatr Urol 2019 Aug 30;15(4):368-373. Epub 2019 Apr 30.

Division of Urology, Nationwide Children's Hospital, Columbus, OH, USA; Center for Surgical Outcomes Research, Nationwide Children's Hospital, Columbus, OH, USA.

Introduction And Objective: Multicystic dysplastic kidney (MCDK) is a congenital renal cystic disease often incidentally diagnosed in children. Historically, children with MCDK underwent early nephrectomy because of concerns for the development of hypertension or malignancy. Over the last decade, management recommendations have not supported routine early surgical removal of MCDK. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.04.024DOI Listing
August 2019
13 Reads

Proteomic Analysis of Urinary Microvesicles and Exosomes in Medullary Sponge Kidney Disease and Autosomal Dominant Polycystic Kidney Disease.

Clin J Am Soc Nephrol 2019 06 24;14(6):834-843. Epub 2019 Apr 24.

Renal Unit, Department of Medicine, University Hospital of Verona, Verona, Italy; and

Background And Objectives: Microvesicles and exosomes are involved in the pathogenesis of autosomal dominant polycystic kidney disease. However, it is unclear whether they also contribute to medullary sponge kidney, a sporadic kidney malformation featuring cysts, nephrocalcinosis, and recurrent kidney stones. We addressed this knowledge gap by comparative proteomic analysis. Read More

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http://dx.doi.org/10.2215/CJN.12191018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556712PMC
June 2019
10 Reads

Magnetic resonance imaging of fibropolycystic liver disease: the spectrum of ductal plate malformations.

Abdom Radiol (NY) 2019 06;44(6):2156-2171

Radiology Unit, Department of Diagnostic and Therapeutic Services, IRCCS ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies), Via Tricomi 5, 90127, Palermo, Italy.

Fibropolycystic liver diseases, also known as ductal plate malformations, are a group of associated congenital disorders resulting from abnormal development of the biliary ductal system. These disorders include congenital hepatic fibrosis, biliary hamartomas, polycystic liver disease, choledochal cysts and Caroli disease. Recently, it has been thought to include biliary atresia in this group of diseases, because ductal plate malformations could be implicated in the pathogenesis of this disease. Read More

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http://dx.doi.org/10.1007/s00261-019-01966-9DOI Listing
June 2019
13 Reads

Nephrocalcinosis in adolescent girl with medullary sponge kidney and mild hemihypertrophy: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14529

Department of Pediatric Nephrology.

Rationale: Medullary sponge kidney (MSK) is a rare congenital abnormality characterized by cystic dilatation of the medullary collecting tubules. The disorder is likely to be complicated by nephrocalcinosis, urolithiasis, tubular dysfunctions, and urinary tract infections. In addition, it may be rarely associated with extrarenal anomalies. Read More

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http://dx.doi.org/10.1097/MD.0000000000014529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407984PMC
February 2019
11 Reads

Heterozygous Pkhd1 mice develop cystic liver disease and proximal tubule ectasia that mimics radiographic signs of medullary sponge kidney.

Am J Physiol Renal Physiol 2019 03 2;316(3):F463-F472. Epub 2019 Jan 2.

Department of Medicine, The University of Alabama at Birmingham , Birmingham, Alabama.

Heterozygosity for human polycystic kidney and hepatic disease 1 ( PKHD1) mutations was recently associated with cystic liver disease and radiographic findings resembling medullary sponge kidney (MSK). However, the relevance of these associations has been tempered by a lack of cystic liver or renal disease in heterozygous mice carrying Pkhd1 gene trap or exon deletions. To determine whether heterozygosity for a smaller Pkhd1 defect can trigger cystic renal disease in mice, we generated and characterized mice with the predicted truncating Pkhd1 mutation in a region corresponding to the middle of exon 20 cluster of five truncating human mutations (between PKHD1 and PKHD1). Read More

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http://dx.doi.org/10.1152/ajprenal.00181.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442377PMC
March 2019
40 Reads

Medullary sponge kidney and Caroli's disease in a patient with stricture urethra: look for the hidden in presence of the apparent.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.

Caroli's disease is a rare congenital disorder with incidence rate of approximately 1 in 1 000 000 population. Renal anomalies which may be associated with Caroli's disease include medullary sponge kidney (MSK), cortical cysts, adult recessive polycystic kidney disease and rarely autosomal dominant polycystic kidney disease. Exact incidence of MSK in patients of Caroli's disease is not known. Read More

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http://dx.doi.org/10.1136/bcr-2018-226746DOI Listing
December 2018
17 Reads

Urinary proteome in inherited nephrolithiasis.

Urolithiasis 2019 Feb 18;47(1):91-98. Epub 2018 Dec 18.

Chair of Nephrology, Department of Translational Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

In the last decades, proteomics has been largely applied to the Nephrology field, with the double aim to (1) elucidate the biological processes underlying renal diseases; (2) identify disease-specific biomarkers, predictor factors of therapeutic efficacy and prognostic factors of disease progression. Kidney stone disease, and in particular, inherited nephrolithiasis (INL) are not an exception. Given the multifactorial origin of these disorders, the combination of genomics and proteomics studies may complement each other, with the final objective to give a global and comprehensive mechanistic view. Read More

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http://dx.doi.org/10.1007/s00240-018-01104-yDOI Listing
February 2019
11 Reads

Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.

Urolithiasis 2019 Feb 23;47(1):115-123. Epub 2018 Nov 23.

UOC Nefrologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Deciding whether to accept a donor with nephrolithiasis is a multifaceted task because of the challenge of finding enough suitable donors while at the same time ensuring the safety of both donors and recipients. Until not long ago, donors with a history of renal stones or with stones emerging during screening on imaging were not considered ideal, but recent guidelines have adopted less stringent criteria for potential donors at risk of stones. This review goes through the problems that need to be approached to arrive at a wise clinical decision, balancing the safety of donors and recipients with the need to expand the organ pool. Read More

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http://dx.doi.org/10.1007/s00240-018-1092-4DOI Listing
February 2019
42 Reads

Medullary sponge kidney.

J Med Imaging Radiat Oncol 2018 Oct;62 Suppl 1:93-94

Department of Radiology, Concord Repatriation General Hospital, Concord, New South Wales, Australia.

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http://doi.wiley.com/10.1111/1754-9485.40_12784
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http://dx.doi.org/10.1111/1754-9485.40_12784DOI Listing
October 2018
13 Reads

Page kidney as a complication after a shock wave lithotripsy: a case report.

CEN Case Rep 2018 11 29;7(2):330-331. Epub 2018 Aug 29.

Department of Nephrology, University Hospital Puerta del Mar, Av. Ana de Viya, 21, 11009, Cádiz, Spain.

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http://dx.doi.org/10.1007/s13730-018-0361-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181889PMC
November 2018
7 Reads

Association of medullary sponge kidney and hyperparathyroidism with RET G691S/S904S polymorphism: a case report.

J Med Case Rep 2018 Jul 9;12(1):197. Epub 2018 Jul 9.

Department of Endocrinology, The Third Xiangya Hospital, Central South University, Tongzipo Road, Changsha, 410007, Hunan Province, People's Republic of China.

Background: Medullary sponge kidney is a rare renal malformation, which usually manifests as nephrocalcinosis, renal tubular acidosis, and recurrent urinary tract infections. Medullary sponge kidney is often associated with renal developmental anomalies and tumors, and its exact pathogenesis is not yet clearly explained. Given the key role of the interaction of glial cell line-derived neurotrophic factor gene, GDNF, and the "rearranged during transfection" proto-oncogene, RET, in kidney and urinary tract development, variations in these genes are proposed to be candidates for medullary sponge kidney. Read More

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http://dx.doi.org/10.1186/s13256-018-1736-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036688PMC
July 2018
61 Reads

Efficacy of Multi-Detector Computed Tomography for the Diagnosis of Medullary Sponge Kidney.

Curr Urol 2018 Mar 20;11(3):139-143. Epub 2018 Feb 20.

Smith Institute for Urology, Hofstra Northwell School of Medicine, New Hyde Park, New York, NY, USA.

Objective: To expand the diagnostic armamentarium for medullary sponge kidney (MSK), we evaluate the use of high-resolution multidetector computed tomography (MDCT) for MSK diagnosis and compare to the standard intravenous urography (IVU). Despite a significant prevalence amongst stone formers, diagnosis of this well described condition has declined. IVU, the gold standard in MSK diagnosis, has largely been replaced by CT, which has previously been shown unable to demonstrate signs of MSK. Read More

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http://dx.doi.org/10.1159/000447208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903462PMC
March 2018
15 Reads

Chronic pain in medullary sponge kidney: a rare and never described clinical presentation.

J Nephrol 2018 08 21;31(4):537-542. Epub 2018 Feb 21.

Divisione di Nefrologia, Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore, Via G. Moscati 31, 00168, Rome, Italy.

Medullary sponge kidney (MSK) is a cause of nephrocalcinosis, associated with hematuria, renal colic, pyelonephritis. There are rare and atypical MSK cases characterized by chronic severe pain (CP), whose features are unknown, in particular the relationship with the stone disease activity. This study analyzes a cohort of MSK-CP patients belonging to three North-America self-support Facebook groups. Read More

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http://dx.doi.org/10.1007/s40620-018-0480-8DOI Listing
August 2018
13 Reads

The genetic framework for development of nephrolithiasis.

Asian J Urol 2017 Jan 28;4(1):18-26. Epub 2016 Nov 28.

Smith Institute for Urology, Hofstra Northwell School of Medicine, Lake Success, NY, USA.

Over 1%-15% of the population worldwide is affected by nephrolithiasis, which remains the most common and costly disease that urologists manage today. Identification of at-risk individuals remains a theoretical and technological challenge. The search for monogenic causes of stone disease has been largely unfruitful and a technological challenge; however, several candidate genes have been implicated in the development of nephrolithiasis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22143882163008
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http://dx.doi.org/10.1016/j.ajur.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730897PMC
January 2017
22 Reads

The "bouquet of flowers" appearance in medullary sponge kidney.

Abdom Radiol (NY) 2018 08;43(8):2206-2207

Section of Radiological Sciences, Di.Bi.Med, University of Palermo, Via del Vespro 127, 90127, Palermo, Italy.

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http://dx.doi.org/10.1007/s00261-017-1420-0DOI Listing
August 2018
15 Reads

[Effects of percutaneous nephrolithotomy in the treatment of medullary sponge kidney with calculi].

Zhonghua Wai Ke Za Zhi 2017 Oct;55(10):742-745

Department of Urology, Peking University People's Hospital, Beijing 100034, China.

To evaluate the effects of percutaneous nephrolithotomy (PNL) in the treatment of medullary sponge kidney with calculi. A total of 77 patients (91 renal units) of medullary sponge kidney with calculi (MSK group) and 77 patients (77 renal units) with common kidney stone (control group) received PNL at Department of Urology in Peking University People's Hospital from September 2006 to February 2016 were analyzed retrospectively. The MSK group included 33 males and 44 females with a mean age of (42. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2017.10.005DOI Listing
October 2017
21 Reads

A giant septal diverticulum in a patient with medullary sponge kidney.

Eur Heart J Cardiovasc Imaging 2017 10;18(10):1189

Department of Cardiology, University Hospital La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain.

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http://dx.doi.org/10.1093/ehjci/jex142DOI Listing
October 2017
19 Reads

Recurrent renal calculi in coexistence of horseshoe kidney and medullary sponge kidney.

Urol Ann 2017 Apr-Jun;9(2):214-215

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.4103/UA.UA_173_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405675PMC
May 2017
23 Reads

Breaking the ice: urine proteomics of medullary sponge kidney disease.

Kidney Int 2017 02;91(2):281-283

Pediatric Translational Research Unit, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand. Electronic address:

Urinary proteomics is a promising tool for biomarker investigation, particularly in complex kidney diseases. Fabris and colleagues report that urinary laminin subunit alpha-2 is a potential diagnostic marker of medullary sponge kidney (MSK) disease by using a label-free quantitative proteomics platform and a clinically compatible enzyme-linked immunosorbent assay. The neglected issue of stone pathogenesis was also evidenced. Read More

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http://dx.doi.org/10.1016/j.kint.2016.10.032DOI Listing
February 2017
10 Reads

Outcomes of living kidney donors with medullary sponge kidney.

Clin Kidney J 2016 Dec 22;9(6):866-870. Epub 2015 Oct 22.

Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA.

Background: Patients with medullary sponge kidney (MSK) commonly encounter recurrent nephrolithiasis. The existing knowledge on safety of donors with MSK has not been studied.

Methods: We conducted a retrospective cohort study at a tertiary referral hospital to assess the outcomes of living kidney donors with MSK. Read More

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http://dx.doi.org/10.1093/ckj/sfv107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5162403PMC
December 2016
17 Reads

Proteomic-based research strategy identified laminin subunit alpha 2 as a potential urinary-specific biomarker for the medullary sponge kidney disease.

Kidney Int 2017 02 1;91(2):459-468. Epub 2016 Dec 1.

Renal Unit, Department of Medicine, University Hospital of Verona, Verona, Italy. Electronic address:

Medullary sponge kidney (MSK) disease, a rare kidney malformation featuring recurrent renal stones and nephrocalcinosis, continues to be diagnosed using expensive and time-consuming clinical/instrumental tests (mainly urography). Currently, no molecular diagnostic biomarkers are available. To identify such we employed a proteomic-based research strategy utilizing urine from 22 patients with MSK and 22 patients affected by idiopathic calcium nephrolithiasis (ICN) as controls. Read More

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http://dx.doi.org/10.1016/j.kint.2016.09.035DOI Listing
February 2017
118 Reads

New non-renal congenital disorders associated with medullary sponge kidney (MSK) support the pathogenic role of GDNF and point to the diagnosis of MSK in recurrent stone formers.

Urolithiasis 2017 Aug 29;45(4):359-362. Epub 2016 Aug 29.

Division of Nephrology, Department of Medical Sciences, Catholic University of the Sacred Heart, Rome, Italy.

Medullary sponge kidney (MSK) is a congenital renal disorder. Its association with several developmental abnormalities in other organs hints at the likelihood of some shared step(s) in the embryogenesis of the kidney and other organs. It has been suggested that the REarranged during Transfection (RET) proto-oncogene and the Glial cell line-Derived Neurotrophic Factor (GDNF) gene are defective in patients with MSK, and both RET and GDNF are known to have a role in the development of the central nervous system, heart, and craniofacial skeleton. Read More

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http://dx.doi.org/10.1007/s00240-016-0913-6DOI Listing
August 2017
65 Reads

Characteristics of renal papillae in kidney stone formers.

Minerva Urol Nefrol 2016 Dec 21;68(6):496-515. Epub 2016 Jul 21.

Department of Urologic Surgery, Vanderbilt Medical Center, Nashville, TN, USA -

The mechanism of kidney stone formation is not well understood. In order to better understand the pathophysiology for specific kidney stone compositions and systemic diseases associated with kidney stones, endoscopic papillary mapping studies with concurrent biopsies have been conducted. This review will summarize the findings of these studies and proposed mechanisms for thirteen disease processes associated with kidney stones. Read More

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December 2016
20 Reads

Sorting the Alphabet Soup of Renal Pathology: A Review.

Curr Probl Diagn Radiol 2018 Nov 28;47(6):417-427. Epub 2016 Jan 28.

Department of Radiology, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA.

Diseases of the kidney often have their names shortened, creating an arcane set of acronyms which can be confusing to both radiologists and clinicians. This review of renal pathology aims to explain some of the most commonly used acronyms within the field. For each entity, a summary of the clinical features, pathophysiology, and radiological findings is included to aid in the understanding and differentiation of these entities. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2016.01.003DOI Listing
November 2018
9 Reads

Safety and efficacy of minimally invasive percutaneous nephrolithotomy in the treatment of patients with medullary sponge kidney.

Urolithiasis 2016 Oct 15;44(5):421-6. Epub 2015 Dec 15.

Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Urology, Guangzhou, 510230, China.

The purpose of this study was to review the safety and efficacy of the minimally invasive percutaneous nephrolithotomy in the treatment of medullary sponge kidney patients with complex renal calculi. Sixteen medullary sponge kidney patients with complex renal calculi underwent minimally invasive percutaneous nephrolithotomy procedures in our center were entered into this retrospective study. The data analyzed included patients' demographics, stone burden, operative time, operative blood loss, length of hospital stay, complications according to the modified Clavien system, and stone-free rate. Read More

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http://dx.doi.org/10.1007/s00240-015-0853-6DOI Listing
October 2016
26 Reads

[Nephrocalcinosis in children].

G Ital Nefrol 2015 Dec;35(Suppl 71)

U.O. Nefrologia Pediatrica, ARNAS Civico Palermo, Italy.

Nephrocalcinosis (NC) is a renal disease characterized by deposition of calcium salts into the renal medulla. There are several causes, organic, iatrogenic, hereditary and sometimes related to extrarenal diseases. We studied 34 children affected by NC, 21 M and 13 F (average age at diagnosis 7. Read More

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December 2015
10 Reads

[Abnormal kidneys].

Rev Med Interne 2016 Jul 26;37(7):507-8. Epub 2015 Oct 26.

Service de radiologie, hôpital militaire My Ismail, Meknès, Maroc.

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http://dx.doi.org/10.1016/j.revmed.2015.09.013DOI Listing
July 2016
12 Reads

Role of Osteogenesis in the Formation of Randall's Plaques.

Anat Rec (Hoboken) 2016 Jan 30;299(1):5-7. Epub 2015 Oct 30.

Division of Nephrology and Dialysis, Columbus-Gemelli University Hospital Catholic University, School of Medicine, Rome, Italy.

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http://dx.doi.org/10.1002/ar.23275DOI Listing
January 2016
15 Reads

The Clinical Efficacy and Safety of Ureteroscopic Laser Papillotomy to Treat Intraductal Papillary Calculi Associated With Medullary Sponge Kidney.

Urology 2015 Sep 8;86(3):472-6. Epub 2015 Jul 8.

Department of Urology, Second Affiliated Hospital of Zhejiang University, Hangzhou, China.

Objective: To evaluate the safety, efficacy, and durability of ureteroscopic laser papillotomy for the treatment of radiographically visible intraductal papillary calculi and/or free collecting system calculi associated with medullary sponge kidney (MSK).

Methods: The medical records of 25 MSK patients who underwent ureteroscopic laser papillotomy were reviewed at our institution from 2010 to 2013. The follow-up was made in our outpatient department. Read More

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http://dx.doi.org/10.1016/j.urology.2015.06.037DOI Listing
September 2015
34 Reads

Nephrocalcinosis in Calcium Stone Formers Who Do Not have Systemic Disease.

J Urol 2015 Nov 16;194(5):1308-12. Epub 2015 May 16.

Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:

Purpose: Nephrocalcinosis is commonly present in primary hyperparathyroidism, distal renal tubular acidosis and medullary sponge kidney disease. To our knowledge it has not been studied in patients with calcium phosphate stones who do not have systemic disease.

Materials And Methods: We studied patients undergoing percutaneous nephrolithotomy who had calcium phosphate or calcium oxalate stones and did not have hyperparathyroidism, distal renal tubular acidosis or medullary sponge kidney disease. Read More

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http://dx.doi.org/10.1016/j.juro.2015.05.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774334PMC
November 2015
50 Reads

Spontaneous calcification process in primary renal cells from a medullary sponge kidney patient harbouring a GDNF mutation.

J Cell Mol Med 2015 Apr 18;19(4):889-902. Epub 2015 Feb 18.

Laboratory of Histomorphology and Molecular Biology of the Kidney, Nephrology Division, Department of Medicine DIMED, University of Padua, Padua, Italy.

Medullary nephrocalcinosis is a hallmark of medullary sponge kidney (MSK). We had the opportunity to study a spontaneous calcification process in vitro by utilizing the renal cells of a patient with MSK who was heterozygous for the c.-27 + 18G>A variant in the GDNF gene encoding glial cell-derived neurotrophic factor. Read More

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http://dx.doi.org/10.1111/jcmm.12514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395202PMC
April 2015
61 Reads

Biopsy proven medullary sponge kidney: clinical findings, histopathology, and role of osteogenesis in stone and plaque formation.

Anat Rec (Hoboken) 2015 May 17;298(5):865-77. Epub 2015 Feb 17.

Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana.

Medullary sponge kidney (MSK) is associated with recurrent stone formation, but the clinical phenotype is unclear because patients with other disorders may be incorrectly labeled MSK. We studied 12 patients with histologic findings pathognomonic of MSK. All patients had an endoscopically recognizable pattern of papillary malformation, which may be segmental or diffuse. Read More

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http://dx.doi.org/10.1002/ar.23105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405475PMC
May 2015
38 Reads

Medullary sponge kidney diagnosed by unenhanced magnetic resonance imaging.

Iran J Kidney Dis 2015 Jan;9(1):18

Department of Nephrology and Endocrinology, National Defense Medical College, Tokorozawa, Saitama, Japan.

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January 2015
15 Reads

Complication and safety of ultrasound guided percutaneous nephrolithotomy in 8,025 cases in China.

Chin Med J (Engl) 2014 ;127(24):4184-9

Department of Urology, Peking University People's Hospital, Beijing 100044, China.

Background: Percutaneous nephrolithotomy (PCNL) was mostly performed with fluoroscopy and/or ultrasonography. The safety and feasibility of PCNL performed totally under ultrasound are not clearly defined. Therefore, we introduce the 9-year experience of 8 025 ultrasound guided PCNL procedures from multiple centers in China performed by the same surgeon, to evaluate the feasibility and security of this technique. Read More

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August 2015
15 Reads

Calcium phosphate stone morphology can reliably predict distal renal tubular acidosis.

J Urol 2015 May 10;193(5):1564-9. Epub 2014 Dec 10.

Assistance Publique-Hôpitaux de Paris, Service des Explorations Fonctionnelles and Institut National de la Santé et de la Recherche Médicale, Unités Mixtes de Recherche S 1155, Hôpital Tenon, Paris, France.

Purpose: Calcium stones represent 85% to 90% of all urinary calculi, including various crystalline compositions and etiological conditions. Calcium phosphate accounts for 10% to 15% of cases. These stones are mainly related to 3 groups of risk factors, including calcium or phosphate metabolism disturbance, renal acidification defects and urinary tract infection. Read More

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http://dx.doi.org/10.1016/j.juro.2014.12.017DOI Listing
May 2015
13 Reads

Familial mixed nephrocalcinosis as a cause of chronic kidney failure: two case reports.

J Med Case Rep 2014 Oct 27;8:355. Epub 2014 Oct 27.

Urology Department, São José do Rio Preto School of Medicine, Avenida Brigadeiro Faria Lima 5416, São José do Rio Preto, SP 15090-000, Brazil.

Introduction: Nephrocalcinosis consists of the deposition of calcium salts in the renal parenchyma and is considered the mixed form when it involves the renal cortex and medulla. The main etiological agents of this condition are primary hyperparathyroidism, renal tubular acidosis, medullary sponge kidney, hyperoxaluria and taking certain drugs. These factors can lead to hypercalcemia and/or hypercalciuria, which can give rise to nephrocalcinosis. Read More

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http://dx.doi.org/10.1186/1752-1947-8-355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217101PMC
October 2014
37 Reads

An unusual case of recurrent hypokalemic paralysis in an adolescent: Questions and Answers.

Pediatr Nephrol 2015 Sep 28;30(9):1437-41. Epub 2014 Aug 28.

Division of Pediatric Nephrology, Department of Pediatrics, Shands Children's Hospital, University of Florida, Gainesville, FL, USA.

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http://link.springer.com/10.1007/s00467-014-2914-4
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http://dx.doi.org/10.1007/s00467-014-2914-4DOI Listing
September 2015
27 Reads

Medullary sponge kidney and isolated hemihyperplasia.

Indian J Nephrol 2014 Jul;24(4):243-5

Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

The term hemihyperplasia refers to an enlargement of body parts beyond the normal asymmetry. Hemihyperplasia can be isolated or associated with various well-described malformation syndromes. Medullary sponge kidney (MSK) has been described with isolated and syndromic hemihyperplasia; the actual prevalence is not known The hemi hypertrophy can be so subtle that it may be easily overlooked. Read More

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http://dx.doi.org/10.4103/0971-4065.133013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119338PMC
July 2014
27 Reads

Inherited renal diseases.

Authors:
Jocelyn C Leung

Curr Pediatr Rev 2014 ;10(2):95-100

Department of Pediatrics, Division of Neonatology, University of Maryland School of Medicine, 110 S. Paca St, 8th floor, Baltimore, MD 21201, USA.

Genetic disorders of the kidney include cystic diseases, metabolic diseases and immune glomerulonephritis. Cystic diseases include autosomal dominant and recessive polycystic kidney disease (ADPKD, ARPKD, respectively). Neonates with enlarged, cystic kidneys should be evaluated for PKD. Read More

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http://dx.doi.org/10.2174/157339631002140513101755DOI Listing
May 2015
12 Reads

[Imaging of medullary sponge kidney: notes for urologists].

Urologia 2014 Oct-Dec;81(4):196-9. Epub 2014 Oct 6.

Dipartimento di Scienze cliniche applicate e biotecnologie, Università degli Studi dell'Aquila, L'Aquila - Italy.

The medullary sponge kidney is a malformation characterized by Bellini ducts' ectasias and often by nephrocalcinosis. Scientific literature demonstrates and emphasizes how the Rx-urography plays a primary role to achieve diagnostic certainty in cases of suspected MSK. Pathognomonic urographic aspects in cases of medullary sponge kidney are defined as "bouquet of flowers", "bunch of grapes" or "brush". Read More

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http://dx.doi.org/10.5301/uro.5000074DOI Listing
December 2016
32 Reads