76,955 results match your criteria Medullary Sponge Kidney


Impaired pressure natriuresis and non-dipping blood pressure in Rats with early type 1 diabetes mellitus.

J Physiol 2018 Dec 7. Epub 2018 Dec 7.

The British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, United Kingdom, EH16 4TJ.

Key Points Summary: Type 1 diabetes mellitus increases cardiovascular risk: hypertension amplifies this risk. Pressure natriuresis regulates long-term blood pressure. We induced type 1 diabetes in rats by streptozotocin injection and after three weeks demonstrated a substantial impairment of pressure natriuresis: acute increases in blood pressure did not increase renal medullary blood flow, and tubular sodium reabsorption was not downregulated. Read More

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December 2018

Genetic testing and surveillance guidelines in hereditary pheochromocytoma and paraganglioma.

J Intern Med 2018 Dec 8. Epub 2018 Dec 8.

Clinical Genetics, Karolinska University Hospital, 171 76, Stockholm.

Pheochromocytomas (PCC) and paragangliomas (PGL), collectively abbreviated PPGL are rare tumours originating from the chromaffin cells in the adrenal medulla (PCC) or the sympathetic or parasympathetic extra-adrenal paraganglia (PGL) (1, 2), Figure 1. The enlarged cell volume leads to increased levels of catecholamines (adrenaline, noraderenaline and/or dopamine) and their metabolites which can be measured in plasma or urine for biochemical diagnosis. Hormone-producing PPGL commonly originate from sympathetic paraganglia in the adrenal glands, abdomen or pelvis (3). Read More

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December 2018

Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus.

Int Immunol 2018 Dec 10. Epub 2018 Dec 10.

Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Hassall's corpuscles (HCs) are composed of cornifying, terminally differentiated medullary thymic epithelial cells (mTECs) that are developed under the control of Aire. Here, we demonstrated that HC-mTECs show features of cellular senescence and produce inflammatory cytokines and chemokines including CXCL5, thereby recruiting and activating neutrophils to produce IL-23 in the thymic medulla. We further indicated that thymic plasmacytoid dendritic cells (pDCs) expressing IL-23 receptors constitutively produced Ifna, which plays a role in single positive (SP) cell maturation, in an Il23a-dependent manner. Read More

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December 2018

DOTA-MGS5, a new cholecystokinin-2 receptor targeting peptide analog with optimized targeting profile for theranostic use.

J Nucl Med 2018 Dec 7. Epub 2018 Dec 7.

Department of Nuclear Medicine, Medical University of Innsbruck, Austria.

Molecular imaging and targeted radiotherapy (TRT) with radiolabeled cholecystokinin-2-receptor (CCK2R) targeting peptide probes holds high promise to improve the clinical management of patients with metastatic medullary thyroid carcinoma (MTC) and other CCK2R-expressing malignancies. Low stability and suboptimal targeting of currently available radiolabeled peptide analogs has prompted us to seek for new stabilization strategies. In this study we present a new minigastrin analog with site-specific C-terminal modifications showing a highly optimized targeting profile. Read More

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December 2018

Diuretic, natriuretic, and vasodepressor activity of a lipid fraction enhanced in medium of cultured mouse medullary interstitial cells by a selective FAAH inhibitor.

J Pharmacol Exp Ther 2018 Dec 7. Epub 2018 Dec 7.

VCU Department of Pharmacology and Toxicology

The relationship between the endocannabinoid system in the renal medulla and the long-term regulation of blood pressure is not understood. To investigate the possible role of the endocannabinoid system in renomedullary interstitial cells, mouse medullary interstitial cells (MMICs) were obtained, cultured and characterized for their responses to treatment with a selective inhibitor of fatty acid amide hydrolase (FAAH), PF-3845. Treatment of MMICs with PF-3845 increased cytoplasmic lipid granules detected by Sudan Black B staining and multilamellar bodies identified by transmission electron microscopy. Read More

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December 2018

PD-1/PD-L1 expressions in medullary thyroid carcinoma: Clinicopathologic and prognostic analysis of Chinese population.

Eur J Surg Oncol 2018 Oct 21. Epub 2018 Oct 21.

Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. Electronic address:

Introduction: Few studies have focused on PD-L1 expression in medullary thyroid carcinoma (MTC). Expressions of PD-1 and PD-L1 and their clinicopathologic and prognostic relevance were therefore further investigated on a relatively large population of MTC patients.

Materials And Methods: Surgical specimens were obtained from 87 MTC patients during a median follow-up of 37. Read More

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October 2018

Computed tomographic morphometric analysis of lateral inclination C1 pedicle screw for atlantoaxial instability patients with a narrow C1 posterior arch.

Authors:
Lei Zhang Huan Wang

Kaohsiung J Med Sci 2018 Dec 19;34(12):700-704. Epub 2018 Sep 19.

Spinal Surgery Unit, Shengjing Hospital of China Medical University, Shenyang, PR China. Electronic address:

Atlanto-axial instability (AAI) is a congenital or developmental condition that leads to instability/subluxation of the atlantoaxial joint. This study is performed to determine anatomic feasibility of trajectory L and help select an optimal screw trajectory in treating patients with AAI with a narrow C1 posterior arch. Sixty patients who underwent cervical three dimensional-computed tomography (3D-CT) were chosen from the hospital's picture archiving and communication system (PACS). Read More

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December 2018

Medullary bone in an Early Cretaceous enantiornithine bird and discussion regarding its identification in fossils.

Nat Commun 2018 12 5;9(1):5169. Epub 2018 Dec 5.

Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, 100044, Beijing, China.

Medullary bone is an ephemeral type of bone tissue, today found only in sexually mature female birds, that provides a calcium reservoir for eggshell formation. The presence of medullary bone-like tissues in extant birds, pterosaurs, and dinosaurs distantly related to birds shows that caution must be exercised before concluding that fossils bear medullary bone. Here we describe a new specimen of pengornithid enantiornithine from the Lower Cretaceous Jiufotang Formation. Read More

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December 2018
5 Reads

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery.

J Vis Exp 2018 Nov 14(141). Epub 2018 Nov 14.

Laboratory of Pharmaceutics, School of Pharmacy, Nihon University;

Intranasal administration has been reported to be a potential pathway for nose-to-brain delivery of therapeutic agents that circumvents the blood-brain barrier. However, there have been few reports regarding not only the quantitative analysis but also optimal administration conditions and dosing regimens for investigations of nose-to-brain delivery. The limited progress in research on nose-to-brain pathway mechanisms using rodents represents a significant impediment in terms of designing nose-to-brain delivery systems for candidate drugs. Read More

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November 2018

Reverse takotsubo cardiomyopathy triggered by a multiple sclerosis relapse.

Acta Neurol Belg 2018 Nov 30. Epub 2018 Nov 30.

Department of Radiology, Université catholique de Louvain (UCLouvain), CHU UCL Namur, Yvoir, Belgium.

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November 2018
1 Read

Dentoalveolar Evaluation of Lower Incisors by CBCT after Treatment with Herbst Appliance.

Braz Dent J 2018 Nov-Dec;29(6):562-568

Department of Orthodontics, Universidade Positivo, Curitiba, PR, Brazil.

This study aimed to evaluate the effects of the Herbst appliance on the proclination and protrusion of the lower incisors, and to verify if the device causes alveolar bone loss in the anterior region of the mandible. This is a retrospective study. The sample consisted of 35 individuals. Read More

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February 2018
3 Reads

Combination of fixative agents and fixation times to visually differentiate the cortical from the medullary layer in bovine adrenal glands.

An Acad Bras Cienc 2018 Oct-Dec;90(4):3887-3891

Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista/UNESP, Via de acesso Paulo Donato Castelane, s/n, 14884-900 Jaboticabal, SP, Brazil.

Chronic stress exposure commonly increases adrenals weight and changes their morphology. This study aimed to compare four methods to delimitate the cortical and medullary layers of adrenals glands in Nelore bulls. Fresh adrenals did not present differentiation between layers. Read More

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May 2018
2 Reads

Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress.

Proc Natl Acad Sci U S A 2018 Dec 4. Epub 2018 Dec 4.

Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany;

The adrenal gland is a master regulator of the human body during response to stress. This organ shows constant replacement of senescent cells by newly differentiated cells. A high degree of plasticity is critical to sustain homeostasis under different physiological demands. Read More

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December 2018
2 Reads

Activation of µ-opioid receptors in the rostral ventrolateral medulla blocks the sympathetic counterregulatory response to glucoprivation.

Am J Physiol Regul Integr Comp Physiol 2018 Dec 3;315(6):R1115-R1122. Epub 2018 Oct 3.

Department of Physiology, Sydney Medical School, The University of Sydney , Sydney, NSW , Australia.

Activation of neurons in the rostral ventrolateral medulla (RVLM) following glucoprivation initiates sympathoadrenal activation, adrenaline release, and increased glucose production. Here, we aimed to determine the role of RVLM µ-opioid receptors in the counterregulatory response to systemic glucoprivation. Experiments were performed in pentobarbital sodium anesthetized male Sprague-Dawley rats ( n = 30). Read More

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December 2018

Cytomorphological Study of Medullary Carcinoma of Breast in Comparison to Infiltrating Ductal Carcinoma.

J Cytol 2018 Oct-Dec;35(4):195-198

Department of Pathology, ESIC MC and PGIMSR, Bengaluru, Karnataka, India.

Introduction: Medullary breast carcinoma (MBC) is one of the rare variants of breast carcinoma, accounting for less than 5% of invasive breast carcinoma. MBCs relatively appear a decade earlier when compared to invasive ductal carcinoma (IDC NOS), which is more prevalent in the elderly age.

Subjects And Methods: A retrospective study was conducted in the Department of Pathology from 2009 to 2016. Read More

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December 2018
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Preclinical IV busulfan dose-finding study to induce reversible myeloablation in a non-human primate model.

PLoS One 2018 29;13(11):e0206980. Epub 2018 Nov 29.

Division of Hematology/Oncology, Department of Medicine, University of Illinois college of Medicine, Chicago, Illinois, United States of America.

In this study we utilized a large animal model to identify a dose of intravenous busulfan that can cause reversible myelosuppression. Nine baboons (Papio anubis) were treated with IV busulfan at 6.4 (Group A), 8 (Group B), or 9. Read More

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November 2018

Effect of Neoadjuvant and Adjuvant Therapy of Experimental Breast Cancer on the Structure of Mesenteric Lymph Nodes.

Bull Exp Biol Med 2018 Dec 28;166(2):245-249. Epub 2018 Nov 28.

Research Institute of Experimental and Clinical Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

The morphometric analysis of mesenteric lymph nodes was carried out in female Wistar rats with chemically induced breast cancer. In control rats with untreated breast cancer, the volume of the system of sinuses increased in parallel with the appearance of morphological signs of suppression of cell-mediated immunity, inhibition of humoral immunity, and macrophage reaction. Against the background of chemotherapy, we observed a decrease in the volume of paracortex and lymphoid nodules, suppression of proliferative activity of lymphoid cells in paracortical and B-cell zone, and a decrease in macrophage content. Read More

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December 2018
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A headache-free reversible cerebral vasoconstriction syndrome (RCVS) with symptomatic brain stem ischemia at late pregnancy as a rare manifestation of RCVS resolved with termination of pregnancy by semi-urgent cesarean section.

Oxf Med Case Reports 2018 Dec 21;2018(12):omy101. Epub 2018 Nov 21.

Department of Neurosurgery, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Minami-Uonuma, Niigata, Japan.

A 32-year-old pregnant woman in her 39th week of pregnancy presented at the emergency room complaining of sudden-onset dizziness with gaze disturbance and was admitted to our hospital. Her past medical history included hypertension, diabetes mellitus and infarction in the right medulla oblongata 18 months prior to this event. Magnetic resonance (MR) angiography showed multiple irregular stenosis of the intracranial arterial system. Read More

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December 2018
1 Read

Inhibitory effects of Mas-related gene (Mrg) C receptor on chronic morphine-induced spinal glial activation.

J Pharmacol Exp Ther 2018 Nov 28. Epub 2018 Nov 28.

Fujian Normal University

Glial activation plays a pivotal role in morphine tolerance. This study investigated effect of Mas-related gene (Mrg) C receptor on morphine-induced activation of microglia and astrocytes in the spinal cord and its underlying mechanisms. Intrathecal (i. Read More

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November 2018
3 Reads

Mutation in precludes transcription factor cooperativity and causes congenital hypoventilation in humans and mice.

Proc Natl Acad Sci U S A 2018 Nov 28. Epub 2018 Nov 28.

Developmental Biology and Signal Transduction Group, Max-Delbrueck-Centrum in the Helmholtz Association, 13125 Berlin, Germany;

The respiratory rhythm is generated by the preBötzinger complex in the medulla oblongata, and is modulated by neurons in the retrotrapezoid nucleus (RTN), which are essential for accelerating respiration in response to high CO Here we identify a frameshift ( ) mutation in patients with congenital central hypoventilation. The mutation alters the C-terminal but not the DNA-binding domain of Mice with the analogous mutation recapitulate the breathing deficits found in humans. Furthermore, the mutation only interferes with a small subset of Lbx1 functions, and in particular with development of RTN neurons that coexpress Lbx1 and Phox2b. Read More

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November 2018
2 Reads

Fusiform vertebral artery aneurysms involving the posterior inferior cerebellar artery origin associated with the sole angiographic anterior spinal artery origin: technical case report and treatment paradigm proposal.

Authors:

J Neurosurg 2018 Oct 1:1-7. Epub 2018 Oct 1.

Fusiform aneurysms of the vertebral artery (VA) involving the posterior inferior cerebellar artery (PICA) origin are uncommon and challenging. The anterior spinal artery (ASA) commonly originates from a unilateral ramus just distal to the PICA. Occlusion of an unpaired ASA can result in bilateral medial medullary syndrome. Read More

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October 2018

Intramedullary versus extramedullary alignment guides on total knee arthroplasty: a meta-analysis.

J Comp Eff Res 2018 Dec 28;7(12):1181-1193. Epub 2018 Nov 28.

Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin 300052, PR China.

Aim: A meta-analysis concentrated on the effect of intramedullary and extramedullary systems on total knee arthroplasty.

Method: Potential academic articles were identified from Cochrane Library, Medline, PubMed, Embase, ScienceDirect, CNKI, WanFang, VIP and other databases. The STATA version was used to analyze the pooled data. Read More

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December 2018
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[Epidemiological scope of traditional gold panning with trauma in emergency service at Gabriel Touré teaching hospital].

Mali Med 2018 ;33(2):5-8

Département anesthésie-réanimation et médecine d'urgence du CHU Gabriel TOURE.

Introduction: Traditional gold washing traumatism during traditional gold panningfalls within the scope of occupational accidents, which are common pathologies in developing countries such as Mali. to study traumatism during traditional gold panning.

Material And Method: A 1-year prospective study from November 2014 to November 2015 on the cases of traumatism during traditional gold washing (TOT) admitted to the emergency room(ER) of the University Hospital Gabriel Touré during the study period. Read More

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January 2018

Innervation of the Nose and Nasal Region of the Rat: Implications for Initiating the Mammalian Diving Response.

Front Neuroanat 2018 13;12:85. Epub 2018 Nov 13.

Department of Physiology, College Graduate Studies, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL, United States.

Most terrestrial animals demonstrate an autonomic reflex that facilitates survival during prolonged submersion under water. This diving response is characterized by bradycardia, apnea and selective increases in peripheral vascular resistance. Stimulation of the nose and nasal passages is thought to be primarily responsible for providing the sensory afferent signals initiating this protective reflex. Read More

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November 2018

Persistent disease and recurrence in medullary thyroid carcinoma: A case series.

Cir Esp 2018 Oct 25. Epub 2018 Oct 25.

Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario Insular de Gran Canaria, Universidad de las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Las Palmas, España.

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October 2018

Effect of IBDV infection on the interfollicular epithelium of chicken bursa of Fabricius.

Poult Sci 2018 Nov 27. Epub 2018 Nov 27.

Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest 1094, Hungary.

In the chicken bursa of Fabricius (BF), the interfollicular epithelium (IFE) consists of cylindrical- and cuboidal-shaped cells. Among the cylindrical-shaped epithelial cells, mucus-producing and caveolin-1 (Cav-1)-expressing cells can be distinguished. Occasionally, the cuboidal-shaped cells also express Cav-1, which suggests that they are precursors of both mucus-producing and Cav-1-expressing cells. Read More

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November 2018
4 Reads

Promoter haplotypes of the corticotropin-releasing hormone encoding gene modulate the physiological stress response in vitro and in vivo.

Stress 2018 Nov 27:1-9. Epub 2018 Nov 27.

a Institute of Psychobiology, Department of Neurobehavioral Genetics , University of Trier , Trier , Germany.

The corticotropin-releasing hormone (CRH) is a neuropeptide mediating stress responses. CRH exerts effects via the hypothalamus pituitary adrenal axis as well as immediate effects on the sympathetic-adrenal-medullary system. Genetic variants of the CRH promoter were previously found to be associated with altered CRH promoter activity and physiological reactions. Read More

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November 2018

Anatomical Variation in Morphometry and Morphology of the Foramen Magnum and Occipital Condyle in Dried Adult Skulls.

J Craniofac Surg 2018 Nov 22. Epub 2018 Nov 22.

School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: The foramen magnum (FM) is the largest opening and is outlet through which medulla oblongata and spinal cord along with meninges, vertebral arteries, anterior and posterior spinal arteries, tectorial membrane, alar ligaments, and spinal branch of the accessory nerve. Occipital condyle (OC) is an important part of craniovertebral or craniocervical junction located anterolaterally on either side of the FM. The objective of the study was to assess variations of FM and OC in Ethiopian dried adult skulls. Read More

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November 2018

Effect of photoperiod on growth performance and quality characteristics of tibia and femur in layer ducks during the pullet phase.

Poult Sci 2018 Nov 23. Epub 2018 Nov 23.

Key Laboratory of Feed Biotechnology of Ministry of Agriculture & Rural Affairs, and National Engineering Research Center of Biological Feed, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.

This study aimed to evaluate the effect of photoperiod on growth performance and bone development in layer ducks during the pullet phase. A total of 480 11-wk-old Jinding layer ducks were randomly divided into 5 groups, receiving 6L (light): 18D (dark), 8L: 16D, 10L: 14D, 12L: 12D, 14L: 10D, respectively. Each group had 6 replicates of 16 birds each. Read More

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November 2018
3 Reads

A Multimodality Review of Adrenal Tumors.

Curr Probl Diagn Radiol 2018 Oct 25. Epub 2018 Oct 25.

Department of Radiology, LSU Health, Shreveport, LA.

Adrenal tumors are very commonly encountered in the practice of radiology. They may arise from the adrenal gland itself, either the cortex or the medulla, or they could be secondary lesions. They may be benign or malignant. Read More

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October 2018
3 Reads

BOLD-fMRI reveals the association between renal oxygenation and functional connectivity in the aging brain.

Neuroimage 2018 Nov 22;186:510-517. Epub 2018 Nov 22.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China. Electronic address:

Aging is accompanied by a decline in physical and cognitive function. Vascular aging may provide a major influence on these measures. The purpose of this study was to explore the relationship between renal oxygenation and functional connectivity of the aging brain because of the anatomic and hemodynamic similarities between cerebral and renal vessels. Read More

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November 2018
6 Reads

Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.

Urolithiasis 2018 Nov 23. Epub 2018 Nov 23.

UOC Nefrologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Deciding whether to accept a donor with nephrolithiasis is a multifaceted task because of the challenge of finding enough suitable donors while at the same time ensuring the safety of both donors and recipients. Until not long ago, donors with a history of renal stones or with stones emerging during screening on imaging were not considered ideal, but recent guidelines have adopted less stringent criteria for potential donors at risk of stones. This review goes through the problems that need to be approached to arrive at a wise clinical decision, balancing the safety of donors and recipients with the need to expand the organ pool. Read More

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November 2018
2 Reads

Colocalization of A but not A adenosine receptors with GABA-ergic neurons in cardiopulmonary chemoreflex network in the caudal nucleus of the solitary tract.

Physiol Rep 2018 Nov;6(22):e13913

Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan.

Adenosine operating in the nucleus of the solitary tract (NTS) may inhibit or facilitate neurotransmitter release from nerve terminals and directly inhibit or facilitate central neurons via A and A pre- and postsynaptic receptors, respectively. However, adenosine A receptors, may also activate GABA-ergic neurons/terminals which in turn inhibit glutamatergic transmission in the NTS network. Our previous studies showed that adenosine operating via both A (inhibitor) and A (activator) receptors powerfully inhibits the cardiopulmonary chemoreflex (CCR) at the level of the caudal NTS. Read More

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November 2018
2 Reads

Catestatin regulates vesicular quanta through modulation of cholinergic and peptidergic (PACAPergic) stimulation in PC12 cells.

Cell Tissue Res 2018 Nov 22. Epub 2018 Nov 22.

Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0732, USA.

We have previously shown that the chromogranin A (CgA)-derived peptide catestatin (CST: hCgA) inhibits nicotine-induced secretion of catecholamines from the adrenal medulla and chromaffin cells. In the present study, we seek to determine whether CST regulates dense core (DC) vesicle (DCV) quanta (catecholamine and chromogranin/secretogranin proteins) during acute (0.5-h treatment) or chronic (24-h treatment) cholinergic (nicotine) or peptidergic (PACAP, pituitary adenylyl cyclase activating polypeptide) stimulation of PC12 cells. Read More

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November 2018
1 Read

CO-related vasoconstriction superimposed on ischemic medullary brain autonomic nuclei may contribute to sudden death.

Cardiovasc Pathol 2018 Oct 26;38:42-45. Epub 2018 Oct 26.

"Lino Rossi" Research Center, Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy. Electronic address:

Introduction: In 2015, a multinational randomized controlled phase IV clinical trial of adaptive servoventilation for the management of heart failure with central sleep apnea was halted in progress because more patients in the study group were dying than in the control group. One year later, another large clinical trial reported results on the effectiveness of continuous positive airway pressure (CPAP) in preventing sudden death and other cardiovascular events such as heart attack and stroke in patients with preexisting vascular disease as well as obstructive sleep apnea.

Background: Sudden unexpected death has been associated with many types of small and nonmalignant medullary brain lesions, like demyelination plaques - largely asymptomatic until they caused sudden death. Read More

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October 2018
4 Reads
2.340 Impact Factor

Correlation Studies and Literature Review of Medullary Artery Occlusion after Intracranial Vertebral Artery Stenting.

World Neurosurg 2018 Nov 19. Epub 2018 Nov 19.

Department of Neurology, The First People's Hospital of Jining, Jining 272011, Shandong, China. Electronic address:

Background: Stenosis of the target intracranial vertebral artery is one of the major causes of posterior circulation ischemic stroke. The objective of this paper is to explore methods for reducing the occurrence of medullary artery occlusion after intracranial vertebral artery stenting.

Case Description: The current research presents a retrospective analysis of 48 patients who received Gateway-Wingspan stent angioplasty to treat severe stenosis of the intracranial vertebral artery, evaluates the results of stenosis remission and perfusion improvement after stent angioplasty, and explores the causes of postoperative medullary artery occlusion. Read More

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November 2018
3 Reads

Understanding Malignancies of the Thyroid Gland: Institutional Experience.

Indian J Otolaryngol Head Neck Surg 2018 Dec 5;70(4):482-489. Epub 2018 Sep 5.

1Department of Otolaryngology and Head Neck Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

To study the epidemiological, pathological characters and determine survival in patients diagnosed of having thyroid gland malignancies. Retrospective chart review of patients having thyroid gland malignancies, which were managed by the two senior authors at our tertiary care institute from January 2000 to December 2006, were performed and evaluated in terms of various clinical, operative and histological parameters. Patients in which follow up of at least 10 years are available were included in the study. Read More

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December 2018
3 Reads

Area postrema syndrome: A short history of a pearl in demyelinating diseases.

Mult Scler 2018 Nov 22:1352458518813105. Epub 2018 Nov 22.

Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

In this topical review, we discuss the history of the area postrema syndrome, with special attention given to early studies aimed at identifying the area postrema and its function, possible early cases of the syndrome and its current relevance in neuroimmunology and demyelinating diseases. In 1896, Retzius named a structure in the posterior medulla oblongata as the area postrema. The work of Borison in the middle of the 20th century led to the elucidation of its function as a "vomiting center. Read More

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November 2018

Plasmacytoma of thyroid clinically and morphologically mimicking primary thyroid carcinoma.

Cytopathology 2018 Nov 21. Epub 2018 Nov 21.

Department of Pathology, Radiology.

Plasma cell neoplasms may have a spectrum of clinical presentation ranging from asymptomatic proliferation to single/multiple mass lesions in medullary/ extramedullary sites. Extramedullary plasmacytoma (EMP) is a rare tumor of the soft tissue without theinvolvement of bone marrow which most commonly affects the head and neck region and may precede multiple myeloma (MM) (1). Thyroid can rarely be a site for EMP or may be infiltrated by systemic multiple myeloma. Read More

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November 2018
2 Reads

Medullary thyroid carcinoma with breast metastasis: Two case reports.

Medicine (Baltimore) 2018 Nov;97(47):e13193

Department of Surgical Oncology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.

Rationale: Medullary thyroid carcinoma (MTC) is an aggressive subtype of thyroid cancer with frequent hematogenous metastasis. While its metastasis is usually observed in the lung, liver, or bone, it rarely migrates to the breast.

Patient Concerns: Here we report 2 cases with a complaint of breast lump after initial treatment of MTC. Read More

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November 2018
3 Reads

Molecular profiling of tumors of the brainstem by sequencing of CSF-derived circulating tumor DNA.

Acta Neuropathol 2018 Nov 20. Epub 2018 Nov 20.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Nan Si Huan Xi Lu 119, Fengtai District, Beijing, 100070, China.

Brainstem gliomas are molecularly heterogeneous diseases, many of which are difficult to safely surgically resect and have limited treatment options due to their eloquent location. These constraints pose challenges to biopsy, which limits the use of routine molecular profiling and identification of personalized therapies. Here, we explored the potential of sequencing of circulating tumor DNA (ctDNA) isolated from the cerebrospinal fluid (CSF) of brainstem glioma patients as a less invasive approach for tumor molecular profiling. Read More

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November 2018
13 Reads

Endoscopic Endonasal Resection of the Odontoid Process in a Patient with Chronic Injury of the C1 Transverse Ligament.

Asian J Neurosurg 2018 Oct-Dec;13(4):1179-1181

Department of Neurosurgery, Sklifosovsky Research Institute of Emergency Care, Moscow, Russia.

Atlas dislocation after transverse ligament injury is one of the most rare types of trauma to the upper cervical level. If magnetic resonance imaging of the craniovertebral junction reveals the Kassam line passing through the cervix of the odontoid process, a transnasal approach can be used for surgical treatment. Here, we present a case in which an endoscopic endonasal approach was used to treat chronic traumatic transligamentous atlas dislocation. Read More

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November 2018
5 Reads

Stress-induced hyperthermia and hypothermia.

Authors:
Takakazu Oka

Handb Clin Neurol 2018 ;157:599-621

Department of Psychosomatic Medicine, International University of Health and Welfare Hospital, Tochigi-ken, Japan. Electronic address:

Stress affects core body temperature (T). Many kinds of stress induce transient, monophasic hyperthermia, which diminishes gradually if the stressor is terminated. Stronger stressors produce a longer-lasting effect. Read More

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January 2018
3 Reads

Mecp2 Disruption in Rats Causes Reshaping in Firing Activity and Patterns of Brainstem Respiratory Neurons.

Neuroscience 2018 Nov 17. Epub 2018 Nov 17.

Department of Biology, Georgia State University, 50 Decatur Street, Atlanta, GA 30302, United States. Electronic address:

People with Rett Syndrome (RTT), a neurodevelopmental disorder caused by mutations in the MECP2 gene, have breathing abnormalities manifested as periodical hypoventilation with compensatory hyperventilation, which are attributable to a high incidence of sudden death. Similar breathing abnormalities have been found in animal models with Mecp2 disruptions. Although RTT-type hypoventilation is believed to be due to depressed central inspiratory activity, whether this is true remains unknown. Read More

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November 2018
5 Reads

Gross Total Resection of a Jugular Foramen Thyroid Medullary Metastasis via a Transjugular Transsigmoid Approach.

J Neurol Surg B Skull Base 2018 Dec 25;79(Suppl 5):S424-S425. Epub 2018 Sep 25.

Department of Neurological Surgery, University of Wisconsin Medical School, Madison, Wisconsin, United States.

Surgical resection of jugular foramen tumors poses a significant challenge to skull base surgeons with the selection of an appropriate surgical approach, a matter of some debate. Jugular foramen metastatic tumors may mimic paragangliomas, and in some selected cases surgical resection is needed. In this video, we demonstrate the microsurgical gross total resection of a jugular foramen tumor via a postauricular trans-jugular trans-sigmoid approach. Read More

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December 2018
3 Reads

Extended Retrosigmoid Approach for the Resection of a Pontomedullary Junction Cavernous Malformation.

J Neurol Surg B Skull Base 2018 Dec 25;79(Suppl 5):S418-S419. Epub 2018 Sep 25.

Department of Neurosurgery, University of Tennessee, Memphis, Tennessee, United States.

 To describe an extended retrosigmoid approach for the resection of a cavernoma involving the ponto-medullary junction, with emphasis on the microsurgical anatomy and technique.  A retrosigmoid craniotomy is performed in the lateral decubitus position and the sigmoid sinus exposed. After opening the dura, sutures are placed medial to the sinus to allow its gentle mobilization. Read More

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December 2018
3 Reads

The Use of Post-ablation Stimulated Thyroglobulin in Predicting Clinical Outcomes in Differentiated Thyroid Carcinoma - What Cut-off Values Should We Use?

Clin Oncol (R Coll Radiol) 2018 Nov 16. Epub 2018 Nov 16.

Department of Clinical Oncology, Prince of Wales Hospital, Shatin, Hong Kong, China.

Aims: Recently published international guidelines recommended using the stimulated thyroglobulin (sTg) post-radioactive iodine (RAI) ablation, in conjunction with tumour stage, as a risk stratification factor. The choice of cut-off values for sTg, namely 1 and 10 ng/ml, was, however, largely based on the functional sensitivities of the assays used, with relatively few published data addressing the prognostic impact of alternative cut-off values. Our study aims to provide data on the prognostic value of sTg at different levels of sensitivities and specificities. Read More

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November 2018
7 Reads