1,263 results match your criteria Medscape Infectious Diseases[Journal]


Pulmonary hypertension in chronic lung disease and hypoxia.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

University of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig University Giessen and Member of the German Center for Lung Research (DZL), Giessen, Germany.

Pulmonary hypertension (PH) frequently complicates the course of patients with various forms of chronic lung disease (CLD). CLD-associated PH (CLD-PH) is invariably associated with reduced functional ability, impaired quality of life, greater oxygen requirements and an increased risk of mortality. The aetiology of CLD-PH is complex and multifactorial, with differences in the pathogenic sequelae between the diverse forms of CLD. Read More

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December 2018

Risk stratification and medical therapy of pulmonary arterial hypertension.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

Cardiovascular Medicine, The University of Michigan, Ann Arbor, MI, USA.

Pulmonary arterial hypertension (PAH) remains a severe clinical condition despite the availability over the past 15 years of multiple drugs interfering with the endothelin, nitric oxide and prostacyclin pathways. The recent progress observed in medical therapy of PAH is not, therefore, related to the discovery of new pathways, but to the development of new strategies for combination therapy and on escalation of treatments based on systematic assessment of clinical response. The current treatment strategy is based on the severity of the newly diagnosed PAH patient as assessed by a multiparametric risk stratification approach. Read More

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December 2018
2 Reads

Treatment-resistant and multi-therapy-resistant criteria for bipolar depression: consensus definition.

Br J Psychiatry 2018 Dec 6:1-9. Epub 2018 Dec 6.

Clinical Senior Lecturer in Mood Disorders and Consultant Psychiatrist,National Affective Disorders Service; Academic Psychiatry Training Programme Lead,Institute of Psychiatry,Psychology and Neuroscience,King's College London,South London and Maudsley NHS Foundation Trust (SLaM); andCRN South London Lead for Mental Health,Centre for Affective Disorders, Institute of Psychiatry,Psychology and Neuroscience,King's College London,South London and Maudsley NHS Foundation Trust (SLaM),UK.

Background: Most people with bipolar disorder spend a significant percentage of their lifetime experiencing either subsyndromal depressive symptoms or major depressive episodes, which contribute greatly to the high levels of disability and mortality associated with the disorder. Despite the importance of bipolar depression, there are only a small number of recognised treatment options available. Consecutive treatment failures can quickly exhaust these options leading to treatment-resistant bipolar depression (TRBD). Read More

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December 2018
5 Reads

Effectiveness of healthcare educational and behavioral interventions to improve gout outcomes: a systematic review and meta-analysis.

Ther Adv Musculoskelet Dis 2018 Dec 19;10(12):235-252. Epub 2018 Nov 19.

Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham VA Medical Center, Faculty Office Tower 805B, 510 20th Street South, Birmingham, AL, 35294, USA.

Background: We aimed to systematically review the effectiveness of healthcare behavioral and education interventions for gout patients on clinical outcomes.

Methods: We searched multiple databases to identify trials or observational studies of educational or behavioral interventions in gout. Risk of bias was assessed with the Cochrane tool for randomized control trials (RCTs) and the Newcastle-Ottawa Scale for observational studies. Read More

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December 2018
2 Reads

Analysis of the Patient Information Quality and Readability on Esophagogastroduodenoscopy (EGD) on the Internet.

Can J Gastroenterol Hepatol 2018 29;2018:2849390. Epub 2018 Oct 29.

Department of Medicine, Section of Digestive diseases, West Virginia University Hospitals, Morgantown, WV, USA.

Objective: Patients are increasingly using the Internet to inform themselves of health-related topics and procedures, including EGD. We analyzed the quality of information and readability of websites after a search on 3 different search engines.

Methods: We used an assessment tool for website quality analysis that we developed in addition to using validated instruments for website quality, Global Quality Score (GQS) and Health on Net (HON) certification. Read More

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October 2018
4 Reads

Obesity paradox on outcome in atrial fibrillation maintained even considering the prognostic influence of biomarkers: insights from the ARISTOTLE trial.

Open Heart 2018 1;5(2):e000908. Epub 2018 Nov 1.

Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.

Objective: We investigated the association between obesity and biomarkers indicating cardiac or renal dysfunction or inflammation and their interaction with obesity and outcomes.

Methods: A total of 14 753 patients in the Apixaban for Reduction In STroke and Other ThromboemboLic Events in Atrial Fibrillation (ARISTOTLE) trial provided plasma samples at randomisation to apixaban or warfarin. Median follow-up was 1. Read More

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November 2018

Psychometric validation of the Perceived Deficits Questionnaire-Depression (PDQ-D) instrument in US and UK respondents with major depressive disorder.

Neuropsychiatr Dis Treat 2018 29;14:2861-2877. Epub 2018 Oct 29.

Global Outcomes Research, Lundbeck SAS, Issy-les-Moulineaux, France.

Background: Although depression and cognitive dysfunction are connected, limited tools exist to capture the patient's perspective on cognitive dysfunction and its impact on major depressive disorder (MDD). We report results of a psychometric validation of the Perceived Deficits Questionnaire-Depression (PDQ-D), a self-report measure of cognitive dysfunction for use in MDD.

Methods: A non-interventional, prospective, panel-recruited, online survey was conducted using the PDQ-D in adults with and without MDD in the US and UK. Read More

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October 2018
4 Reads

Association of low income with pulmonary disease progression in smokers with and without chronic obstructive pulmonary disease.

ERJ Open Res 2018 Oct 12;4(4). Epub 2018 Nov 12.

Dept of Medicine, National Jewish Health, Denver, CO, USA.

Low socioeconomic status has been associated with chronic obstructive pulmonary disease (COPD) but little is known about its impact on disease progression. We assessed the association of income to symptoms, pulmonary disease severity and progression in smokers with and without COPD. The COPDGene cohort of 4826 smokers who reported annual income in phase 2 was analysed. Read More

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October 2018
3 Reads

Systemic sclerosis: state of the art on clinical practice guidelines.

RMD Open 2018 18;4(Suppl 1):e000782. Epub 2018 Oct 18.

Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy.

Systemic sclerosis (SSc) is an orphan disease characterised by autoimmunity, fibrosis of the skin and internal organs, and vasculopathy. SSc may be associated with high morbidity and mortality. In this narrative review we summarise the results of a systematic literature research, which was performed as part of the European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases project, aimed at evaluating existing clinical practice guidelines or recommendations. Read More

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October 2018
11 Reads

Provocative biomarker stress test: stress-delta N-terminal pro-B type natriuretic peptide.

Open Heart 2018 8;5(2):e000847. Epub 2018 Oct 8.

Division of Cardiology, Department of Medicine, Duke Clinical Research Institute, Durham, North Carolina, USA.

Objective: Stress testing is commonly performed in emergency department (ED) patients with suspected acute coronary syndrome (ACS). We hypothesised that changes in N-terminal pro-B type natriuretic peptide (NT-proBNP) concentrations from baseline to post-stress testing (stress-delta values) differentiate patients with ischaemic stress tests from controls.

Methods: We prospectively enrolled 320 adult patients with suspected ACS in an ED-based observation unit who were undergoing exercise stress echocardiography. Read More

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October 2018
9 Reads

The acute efficacy of antipsychotics in schizophrenia: a review of recent meta-analyses.

Ther Adv Psychopharmacol 2018 Nov 8;8(11):303-318. Epub 2018 Oct 8.

The Zucker Hillside Hospital, Psychiatry Research, Glen Oaks, NY, USA Department of Psychiatry and Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, NY, USA Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany.

Schizophrenia is the eighth leading cause of disability worldwide in people aged 15-44 years. Before antidopaminergic antipsychotics were introduced in the 1950s, no effective medications existed for the treatment of schizophrenia. This review summarizes key meta-analytic findings regarding antipsychotic efficacy in the acute treatment of schizophrenia, including clozapine in treatment-resistant patients. Read More

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November 2018
5 Reads

Antibiotic resistance among bacterial conjunctival pathogens collected in the Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) surveillance study.

PLoS One 2018 18;13(10):e0205814. Epub 2018 Oct 18.

Bausch + Lomb, Rochester, New York, United States of America.

The Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) surveillance study evaluates in vitro antibiotic resistance among Staphylococcus aureus, coagulase-negative staphylococci (CoNS), Streptococcus pneumoniae, Pseudomonas aeruginosa, and Haemophilus influenzae isolates from ocular infections. Here we report resistance rates and trends among conjunctival-sourced ocular isolates collected across the US from 2009 through 2016. A total of 1198 conjunctival isolates (483 S. Read More

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October 2018
3 Reads

Women manifest more severe COPD symptoms across the life course.

Int J Chron Obstruct Pulmon Dis 2018;13:3021-3029. Epub 2018 Oct 1.

Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO, USA.

Background: Previous studies suggest that gender differences exist in COPD diagnosis and symptoms; these differences may be more pronounced in younger adults. Our objective was to explore age-associated gender differences across a range of COPD severities.

Materials And Methods: A total of 4,484 current and former smokers with COPD from the Genetic Epidemiology of COPD cohort were investigated using regression modeling to explore the association between gender, age, disease severity, and the contributing elements of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification system (symptoms, exacerbation risk, airflow limitation). Read More

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October 2018
8 Reads

Reliability of Sonoelastography in Ductal Carcinoma.

Ultrasound Med Biol 2019 Jan 8;45(1):21-25. Epub 2018 Oct 8.

University of Lahore, Lahore, Pakistan.

The objective of the study was to evaluate the reliability of sonoelastography in ductal carcinoma in patients in primary and secondary health care settings. Google Scholar, PubMed, Medline, Medscape, Wikipedia and NCBI were searched in January 2018 for all original research and review articles to identify relevant studies. Two reviewers selected the articles independently for based on the title and abstract. Read More

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January 2019

Tapering Janus kinase inhibitors in rheumatoid arthritis with low disease activity or remission: reality or dream?

Ann Rheum Dis 2018 Oct 9. Epub 2018 Oct 9.

Medicine Service, Birmingham VA Medical Center, Birmingham, Alabama, USA

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October 2018
2 Reads

Assessment of Instrumental Activities of Daily Living in Older Adults with Subjective Cognitive Decline Using the Virtual Reality Functional Capacity Assessment Tool (VRFCAT).

J Prev Alzheimers Dis 2018 ;5(4):216-234

Alexandra S. Atkins, Ph.D., Vice President- Scientific Development, NeuroCog Trials, 3211 Shannon Road, Suite 300, Durham, NC 27707, USA, ph. (919) 401-4642, fx. (919) 401-4644, email:

Background: Continuing advances in the understanding of Alzheimer's disease progression have inspired development of disease-modifying therapeutics intended for use in preclinical populations. However, identification of clinically meaningful cognitive and functional outcomes for individuals who are, by definition, asymptomatic remains a significant challenge. Clinical trials for prevention and early intervention require measures with increased sensitivity to subtle deficits in instrumental activities of daily living (IADL) that comprise the first functional declines in prodromal disease. Read More

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January 2018
10 Reads

and progression of lung disease in children with cystic fibrosis.

Thorax 2018 Oct 1. Epub 2018 Oct 1.

School of Pharmacy, University of Queensland, Brisbane, Queensland, Australia.

Background: The impact of on lung disease in young children with cystic fibrosis is uncertain.

Aims: To determine if positive respiratory cultures of species are associated with: (1) increased structural lung injury at age 5 years; (2) accelerated lung function decline between ages 5 years and 14 years and (3) to identify explanatory variables.

Methods: A cross-sectional analysis of association between positive bronchoalveolar lavage (BAL) cultures and chest high-resolution CT (HRCT) scan findings at age 5 years in subjects from the Australasian Cystic Fibrosis Bronchoalveolar Lavage (ACFBAL) study was performed. Read More

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October 2018
13 Reads

A systematic review of clinical outcomes on the WHO Category II retreatment regimen for tuberculosis.

Int J Tuberc Lung Dis 2018 Oct;22(10):1127-1134

Liverpool School of Tropical Medicine, Liverpool, UK.

Objective: To assess the clinical outcomes of patients prescribed the World Health Organization (WHO) Category II retreatment regimen for tuberculosis (TB).

Design: A systematic review of the literature was performed by searching Medscape, Embase and Scopus databases for cohort studies and clinical trials reporting outcomes in adult patients on the Category II retreatment regimen.

Results: The proportion of patients successfully completing the retreatment regimen varied from 27% to 92% in the 39 studies included in this review. Read More

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October 2018

Endophthalmitis rates among patients receiving intravitreal anti-VEGF injections: a USA claims analysis.

Clin Ophthalmol 2018 30;12:1625-1635. Epub 2018 Aug 30.

Genentech, Inc., South San Francisco, CA, USA.

Purpose: Intravitreal (IVT) injections of the anti-vascular endothelial growth factor (VEGF) agents aflibercept, bevacizumab, and ranibizumab are commonly prescribed to treat neovascular age-related macular degeneration (nAMD). Studies comparing inflammation rates in large populations of patients receiving these agents and the treatment of ocular inflammation post-IVT anti-VEGF injections are scarce. In this study, we compared rates of endophthalmitis claims (sterile and infectious) following IVT anti-VEGF injections to determine the risk factors associated with developing endophthalmitis, and examined the claims for subsequent treatment. Read More

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Effect of apixaban compared with warfarin on coagulation markers in atrial fibrillation.

Heart 2018 Sep 12. Epub 2018 Sep 12.

Uppsala Clinical Research Center (UCR), Uppsala University, Uppsala, Sweden.

Objectives: Compare the effect of apixaban and warfarin on coagulation and primary haemostasis biomarkers in atrial fibrillation (AF).

Methods: The biomarker substudy from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial included 4850 patients with AF randomised to treatment with apixaban or warfarin. Sixty per cent of patients used vitamin K antagonist (VKA) within 7 days before randomisation. Read More

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September 2018
13 Reads

Seasonal plasticity of cognition and related biological measures in adults with and without Alzheimer disease: Analysis of multiple cohorts.

PLoS Med 2018 Sep 4;15(9):e1002647. Epub 2018 Sep 4.

Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, New York, United States of America.

Background: There are few data concerning the association between season and cognition and its neurobiological correlates in older persons-effects with important translational and therapeutic implications for the diagnosis and treatment of Alzheimer disease (AD). We aimed to measure these effects.

Methods And Findings: We analyzed data from 3,353 participants from 3 observational community-based cohort studies of older persons (the Rush Memory and Aging Project [MAP], the Religious Orders Study [ROS], and the Minority Aging Research Study [MARS]) and 2 observational memory-clinic-based cohort studies (Centre de Neurologie Cognitive [CNC] study at Lariboisière Hospital and the Sunnybrook Dementia Study [SDS]). Read More

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September 2018
9 Reads

Assessment of internet sources on subungual melanoma.

Melanoma Res 2018 Aug 30. Epub 2018 Aug 30.

Department of Dermatology, Weill Cornell Medicine College, New York, New York, USA.

In this study, we sought to objectively determine the accuracy and comprehensibility of online material with regard to subungual melanoma, a nail disease that is rare within the general population, yet has high incidence in certain patient groups, and carries a poorer prognosis than other forms of cutaneous melanoma. Because improved prognosis relies on early diagnosis, the dissemination of accurate, understandable information is an important factor in patient education and health. Using a pro forma designed to score website reliability, the accountability, quality, readability, display, support features, and transparency of the most commonly listed search engine hits related to subungual melanoma were analyzed. Read More

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August 2018
5 Reads

Exercise right heart catheterisation before and after pulmonary endarterectomy in patients with chronic thromboembolic disease.

Eur Respir J 2018 Sep 17;52(3). Epub 2018 Sep 17.

Dept of Thoracic Surgery, Kerckhoff Heart and Lung Center, Bad Nauheim, Germany.

Symptomatic patients with chronic thromboembolic disease (CTED) without pulmonary hypertension often show an excessive increase in mean pulmonary arterial pressure (MPAP) during exercise.We report on the impact of pulmonary endarterectomy (PEA) on pulmonary haemodynamics in a prospective series of 32 consecutive CTED patients who underwent PEA. All patients had a comprehensive diagnostic work-up including right heart catheterisation at baseline and 12 months after PEA. Read More

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September 2018
2 Reads

Post hoc analyses of asenapine treatment in pediatric patients with bipolar I disorder: efficacy related to mixed or manic episode, stage of illness, and body weight.

Neuropsychiatr Dis Treat 2018 2;14:1941-1952. Epub 2018 Aug 2.

Toronto Western Research Institute, Toronto, ON, Canada.

Background: Patient characteristics and disease progression may affect response to pharmacologic intervention in bipolar I disorder. Asenapine is approved for acute treatment of manic/mixed episodes of bipolar I disorder in patients 10-17 years old. Post hoc analyses assessed asenapine efficacy in pediatric patients by current manic or mixed episode, number of lifetime episodes, and baseline body mass index (BMI). Read More

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August 2018
1 Read

Apixaban versus Dalteparin for the Treatment of Acute Venous Thromboembolism in Patients with Cancer: The Caravaggio Study.

Thromb Haemost 2018 Sep 13;118(9):1668-1678. Epub 2018 Aug 13.

Internal Medicine, S. Antonio Hospital, Padua, Italy.

International and national guidelines recommend low-molecular-weight heparin for the treatment of venous thromboembolism (VTE) in patients with cancer. The aim of the Caravaggio study is to assess whether oral apixaban is non-inferior to subcutaneous dalteparin for the treatment of acute proximal deep vein thrombosis and/or pulmonary embolism in patients with cancer. The study is an investigator-initiated, multi-national, prospective, randomized, open-label with blind end-point evaluation (PROBE), non-inferiority clinical trial (NCT03045406). Read More

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September 2018
20 Reads

Precision medicine in COPD: where are we and where do we need to go?

Eur Respir Rev 2018 Sep 1;27(149). Epub 2018 Aug 1.

Division of Pulmonary and Critical Care Medicine, Dept of Medicine, University of Michigan Health System, Ann Arbor, MI, USA.

Chronic obstructive pulmonary disease (COPD) was the fourth leading cause of death worldwide in 2015. Current treatments for patients ease discomfort and help decrease disease progression; however, none improve lung function or change mortality. COPD is heterogeneous in its molecular and clinical presentation, making it difficult to understand disease aetiology and define robust therapeutic strategies. Read More

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September 2018
10 Reads

Clinical Impact of Bleeding in Cancer-Associated Venous Thromboembolism: Results from the Hokusai VTE Cancer Study.

Thromb Haemost 2018 Aug 30;118(8):1439-1449. Epub 2018 Jul 30.

University of Oklahoma Health Sciences Center, College of Public Health, University of Oklahoma, Oklahoma City, Oklahoma, United States.

In the Hokusai VTE Cancer study, edoxaban was non-inferior to dalteparin for the composite outcome of recurrent venous thromboembolism (VTE) and major bleeding in 1,050 patients with cancer-associated VTE. The absolute rate of recurrent VTE was 3.4% lower with edoxaban, whereas the absolute rate of major bleeding was 2. Read More

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August 2018
15 Reads

Leg Fracture Associated with Synostosis of Interosseous Membrane During Running in A Soccer Player.

Transl Med UniSa 2017 Jul 31;17:1-5. Epub 2018 Mar 31.

Department of Orthopaedics and Traumatology, University of Rome "Tor Vergata", Rome, Italy.

Introduction: Leg fractures may occur frequently in sport injuries but it is very rare to find this kind of injury associated with interosseous membrane synostosis. This case report describes a unique case of 42 B1.2 fracture of the leg associated with an interosseous membrane synostosis and literature review on Pubmed, Google scholar and Medscape. Read More

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July 2017
1 Read

Clozapine and long-acting injectable antipsychotics reduce hospitalisation and treatment failure risk in patients with schizophrenia.

Evid Based Ment Health 2018 Aug 11;21(3):e11. Epub 2018 Jul 11.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Glen Oaks, New York, USA.

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Occupation-associated health hazards for the gastroenterologist/endoscopist.

Ann Gastroenterol 2018 Jul-Aug;31(4):448-455. Epub 2018 Apr 27.

Eden Medical Center, Castro Valley, CA (Vishal Ghevariya), USA.

Advances in the field of endoscopy have allowed gastroenterologists to obtain detailed imaging of anatomical structures and to treat gastrointestinal diseases with endoscopic therapies. However, these technological developments have exposed endoscopists and staff to hazards such as musculoskeletal injuries, exposure to infectious agents, and ionizing radiation. We aimed to review the occupational hazards for the gastroenterologist and endoscopist. Read More

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April 2018
1 Read

Has Rheumatology Become A More Attractive Career Choice? Comparison Of Trends In The Rheumatology Fellowship Match From 2008 To 2013 With 2014 To 2017.

Arthritis Care Res (Hoboken) 2018 Jun 28. Epub 2018 Jun 28.

Division of Rheumatology, Departments of Medicine, Keck School of Medicine, University of Southern California, and Los Angeles County + University of Southern California (LAC+USC) Medical Center, Los Angeles, California.

Objective: Rheumatology has been a less attractive career choice than other internal medicine (IM) subspecialties. Recent fellowship "Match" data suggested this may have changed. We therefore evaluated the current attractiveness of rheumatology and compared it with other medical subspecialties. Read More

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June 2018
1 Read

Development and validation of a radiological diagnosis model for hypersensitivity pneumonitis.

Eur Respir J 2018 Aug 16;52(2). Epub 2018 Aug 16.

Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor, MI, USA.

High-resolution computed tomography (HRCT) may be useful for diagnosing hypersensitivity pneumonitis. Here, we develop and validate a radiological diagnosis model and model-based points score.Patients with interstitial lung disease seen at the University of Michigan Health System (derivation cohort) or enrolling in the Lung Tissue Research Consortium (validation cohort) were included. Read More

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August 2018
20 Reads

Can CAPTURE be used to identify undiagnosed patients with mild-to-moderate COPD likely to benefit from treatment?

Int J Chron Obstruct Pulmon Dis 2018 13;13:1901-1912. Epub 2018 Jun 13.

University of Minnesota, Department of Family & Community Health, Minneapolis, MN & COPD Foundation, Miami, FL, USA.

Background: COPD Assessment in Primary Care To Identify Undiagnosed Respiratory Disease and Exacerbation Risk (CAPTURE™) uses five questions and peak expiratory flow (PEF) thresholds (males ≤350 L/min; females ≤250 L/min) to identify patients with a forced expiratory volume in 1 second (FEV)/forced vital capacity (FVC) <0.70 and FEV <60% predicted or exacerbation risk requiring further evaluation for COPD. This study tested CAPTURE's ability to identify symptomatic patients with mild-to-moderate COPD (FEV 60%-80% predicted) who may also benefit from diagnosis and treatment. Read More

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June 2018
11 Reads

Non-vitamin K Antagonist Oral Anticoagulant After Acute Coronary Syndrome: Is There a Role?

Interv Cardiol 2018 May;13(2):93-98

Icahn School of Medicine, Mount Sinai Hospital, New York NY, USA.

Despite dual antiplatelet therapy (DAPT) including potent P2Y12 inhibitors, recurrent ischaemic events occur in a significant number of patients after acute coronary syndrome (ACS), warranting new antithrombotic strategies. Combinations of non-vitamin K antagonist oral anticoagulant (NOAC) with antiplatelet therapy have been tested in several large phases II and III randomised trials. Overall, current evidence suggests that the use of NOACs on top of DAPT after ACS reduces the rate of recurrent ischaemic events, albeit at the price of increased risk for major bleeding. Read More

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May 2018
5 Reads

Initiating/maintaining long-acting injectable antipsychotics in schizophrenia/schizoaffective or bipolar disorder - expert consensus survey part 2.

Neuropsychiatr Dis Treat 2018 8;14:1475-1492. Epub 2018 Jun 8.

Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY, USA.

Objective: The aim of this study was to provide recommendations on initiating and maintaining long-acting injectable antipsychotics (LAIs) in individuals with schizophrenia/schizoaffective or bipolar disorder.

Methods: A 50-question survey comprising 916 response options was completed by 34 expert researchers and high prescribers with extensive LAI experience, rating relative appropriateness/importance on a 9-point scale. Consensus was determined using chi-square test of score distributions. Read More

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June 2018
4 Reads

Identifying patients and clinical scenarios for use of long-acting injectable antipsychotics - expert consensus survey part 1.

Neuropsychiatr Dis Treat 2018 8;14:1463-1474. Epub 2018 Jun 8.

Cell Biology and Neuroscience, Center for Mental Health Research and Recovery, Montana State University, Bozeman, MT, USA.

Objective: To assess expert consensus on barriers and facilitators for long-acting injectable antipsychotic (LAI) use and provide clinical recommendations on issues where clinical evidence is lacking, including identifying appropriate clinical situations for LAI use.

Methods: A 50-question survey comprising 916 response options was distributed to 42 research experts and high prescribers with extensive LAI experience. Respondents rated options on relative appropriateness/importance using a 9-point scale. Read More

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June 2018
3 Reads

Cancer risk in HIV patients with incomplete viral suppression after initiation of antiretroviral therapy.

PLoS One 2018 5;13(6):e0197665. Epub 2018 Jun 5.

Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

Background: Cancer causes significant morbidity and mortality among HIV patients in the US due to extended life expectancy with access to effective antiretroviral therapy. Low, detectable HIV RNA has been studied as a risk factor for adverse health outcomes, but its clinical impact on cancer risk remains unclear. The objective of this study was to determine whether HIV RNA <1,000 copies/mL six months after starting therapy was associated with 10-year first cancer risk. Read More

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November 2018
10 Reads

Diagnostic accuracy of sonoelastography in different diseases.

J Ultrason 2018 Mar 30;18(72):29-36. Epub 2018 Mar 30.

FAHS, University of Lahore, Lahore, Pakistan.

The objective of this study was to evaluate the diagnostic accuracy of sonoelastography in patients of primary and secondary health care settings. Google scholar, PubMed, Medline, Medscape, Wikipedia and NCBI were searched in October 2017 for all original studies and review articles to identify the relevant material. Two reviewers independently selected articles for evaluation of the diagnostic accuracy of sonoelastography in different diseases based on titles and abstracts retrieved by the literature search. Read More

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March 2018
1 Read

Treatment of tardive dyskinesia with VMAT-2 inhibitors: a systematic review and meta-analysis of randomized controlled trials.

Drug Des Devel Ther 2018 14;12:1215-1238. Epub 2018 May 14.

Department of Psychiatry, Northwell Health, The Zucker Hillside Hospital, Glen Oaks, NY, USA.

Aim: The aim of this study was to summarize the characteristics, efficacy, and safety of vesicular monoamine transporter-2 (VMAT-2) inhibitors for treating tardive dyskinesia (TD).

Materials And Methods: We conducted a literature search in PubMed, Cochrane Database, and ClinicalTrials.gov, screening for systematic reviews, meta-analyses or double-blind, randomized, placebo-controlled trials (DBRPCTs) reporting efficacy or safety data of VMAT-2 inhibitors (tetrabenazine, deutetrabenazine, and valbenazine) in patients with TD. Read More

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October 2018
2 Reads

Comparison of Nine Tools for Screening Drug-Drug Interactions of Oral Oncolytics.

J Oncol Pract 2018 Jun 22;14(6):e368-e374. Epub 2018 May 22.

University of Michigan, Ann Arbor, MI.

Purpose: Patients with cancer are an especially vulnerable population to potential drug-drug interactions (DDIs). This makes it important to adequately screen them for DDIs. The objective of this study was to compare the abilities of nine DDI screening tools to detect clinically relevant interactions with oral oncolytics. Read More

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June 2018
2 Reads

Estimated prevalence and incidence of diagnosed ADHD and health care utilization in adults in Sweden - a longitudinal population-based register study.

Neuropsychiatr Dis Treat 2018 7;14:1149-1161. Epub 2018 May 7.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Background: Although the worldwide prevalence of attention-deficit/hyperactivity disorder (ADHD) in adults is estimated to be between 2% and 5%, it is considered to be underdiagnosed. This register study explored the prevalence of diagnosed ADHD and incidence of newly diagnosed ADHD in Swedish adults over time, and assessed comorbidities and pharmacologic treatment.

Methods: National Patient Register data were used to estimate the overall prevalence of adults (≥18 years) with a registered ADHD diagnosis from 2006 to 2011, and the incidence of newly registered diagnoses from 2007 to 2011. Read More

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May 2018
2 Reads

Are peripheral blood eosinophil counts a guideline for omalizumab treatment? STELLAIR says no!

Authors:
William W Busse

Eur Respir J 2018 May 10;51(5). Epub 2018 May 10.

Dept of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

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Emerging Transcatheter Options for Tricuspid Regurgitation.

Methodist Debakey Cardiovasc J 2017 Jul-Sep;13(3):120-125

HOUSTON METHODIST DEBAKEY HEART & VASCULAR CENTER, HOUSTON METHODIST HOSPITAL, HOUSTON, TEXAS.

Tricuspid regurgitation (TR) presents as either primary valve pathology or secondary to pulmonary or left-sided heart disease. Severe TR portends a worse prognosis independent of age, right ventricular size and function, severe left ventricular dysfunction, and increased pulmonary arterial pressures. Surgical treatment for TR has mostly been limited to patients undergoing mitral valve repair since those at high surgical risk are not candidates for traditional TR surgery. Read More

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August 2018
7 Reads

Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and network meta-analysis.

Gut 2018 May 5. Epub 2018 May 5.

Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK.

Objective: Opioids are increasingly prescribed in the West and have deleterious GI consequences. Pharmacological therapies to treat opioid-induced constipation (OIC) are available, but their relative efficacy is unclear. We performed a systematic review and network meta-analysis to address this deficit in current knowledge. Read More

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May 2018
5 Reads

Peri-operative Adverse Outcomes in Patients with Atrial Fibrillation Taking Warfarin or Edoxaban: Analysis of the ENGAGE AF-TIMI 48 Trial.

Thromb Haemost 2018 Jun 3;118(6):1001-1008. Epub 2018 May 3.

Department of Medicine, Brigham and Women's Hospital, Harvard University, Boston, Massachusetts, United States.

Background:  Peri-operative management of anticoagulated patients with atrial fibrillation (AF) is challenging. To gain information on the peri-operative management of edoxaban, we compared outcomes in patients on warfarin or edoxaban enrolled in ENGAGE AF-TIMI 48 who underwent a surgery or invasive procedure.

Methods:  Data from patients undergoing their first surgery/procedure were analysed and results compared by anticoagulant (warfarin vs. Read More

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June 2018
1 Read

Treatment of Cluster Headache.

Ann Indian Acad Neurol 2018 Apr;21(Suppl 1):S9-S15

Department of Neurology, Mayo Clinic, Scottsdale, Arizona, USA.

Cluster headache (CH) is a debilitating primary headache disorder. Although uncommon, affecting only 0.1% of population, it is one of the most painful conditions known to humankind. Read More

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April 2018
5 Reads

Potential Drug-Drug Interactions among Patients prescriptions collected from Medicine Out-patient Setting.

Pak J Med Sci 2018 Jan-Feb;34(1):144-148

Dr. Mehtab Munir, MBBS. Senior Lecturer, Pharmacology Department, Bahria University Medical and Dental College Sailors Street, Adjacent PNS Shifa, Defence Phase -2, Karachi, Pakistan.

Objective: To identify and evaluate the frequency, severity, mechanism and common pairs of drug-drug interactions (DDIs) in prescriptions by consultants in medicine outpatient department.

Methods: This cross sectional descriptive study was done by Pharmacology department of Bahria University Medical & Dental College (BUMDC) in medicine outpatient department (OPD) of a private hospital in Karachi from December 2015 to January 2016. A total of 220 prescriptions written by consultants were collected. Read More

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Long-Term Evaluation of the Effects of Aclidinium Bromide on Major Adverse Cardiovascular Events and COPD Exacerbations in Patients with Moderate to Very Severe COPD: Rationale and Design of the ASCENT COPD Study.

Chronic Obstr Pulm Dis 2018 Jan 24;5(1):5-15. Epub 2018 Jan 24.

6-AstraZeneca Research & Development Centre, Barcelona, Spain.

Chronic obstructive pulmonary disease (COPD) is a heterogeneous illness characterized by persistent airflow obstruction and exacerbations. Patients typically experience a decline in lung function, increasingly impaired health-related quality of life, and high mortality. Poor lung function and exacerbations are associated with an increased risk of cardiovascular (CV) and cerebrovascular events, and approximately 30% of patients with COPD die from CV‑related disease. Read More

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January 2018
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The use of optical coherence tomography angiography for detecting choroidal neovascularization, compared to standard multimodal imaging.

Authors:
T Soomro J Talks

Eye (Lond) 2018 04 30;32(4):661-672. Epub 2018 Mar 30.

Newcastle Eye Centre, Ophthalmology Department, Royal Victoria Infirmary, Newcastle-upon-tyne, NE1 4LP, UK.

PurposeTo assess OCT angiography (OCTA) effectiveness at detecting choroidal neovascularization (CNV) in cases of suspected neovascular age related macular degeneration (nAMD), chronic central serous retinopathy (cCSR) and pathological myopia compared to FFA and how it compares to a multimodal approach (OCT, FFA and ICGA) for detecting the vascular network.MethodsThis was a retrospective observational cohort study of patients who had clinical and/or OCT findings suggestive of CNV, having further investigation with FFA, with or without ICG, and had same day OCTA using the Heidelberg Spectralis OCT2 beta angiography module. Multimodal imaging interpretation was compared to OCTA images. Read More

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April 2018
4 Reads