1,274 results match your criteria Medscape HIV/AIDS[Journal]


If Trousseau had a stroke.

Authors:
Alok A Khorana

Blood 2019 Feb;133(8):769-770

Cleveland Clinic.

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http://dx.doi.org/10.1182/blood-2019-01-894261DOI Listing
February 2019

Mortality and Exacerbations by Global Initiative for Chronic Obstructive Lung Disease Groups ABCD: 2011 Versus 2017 in the COPDGene® Cohort.

Chronic Obstr Pulm Dis 2019 Jan 10;6(1):64-73. Epub 2019 Jan 10.

Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor.

The Global initiative for chronic Obstructive Lung Disease (GOLD) ABCD groupings were recently modified. The GOLD 2011 guidelines defined increased risk as forced expiratory volume in 1 second (FEV) < 50% predicted or ≥ 2 outpatient or ≥ 1 hospitalized exacerbation in the prior year, whereas the GOLD 2017 guidelines use only exacerbation history. We compared mortality and exacerbation rates in the Genetic Epidemiology of COPD Study cohort (COPDGene) by 2011 (exacerbation history/FEV and dyspnea) versus 2017 (exacerbations and dyspnea) classifications. Read More

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http://dx.doi.org/10.15326/jcopdf.6.1.2018.0130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373581PMC
January 2019

Prospective observational study in patients with obstructive lung disease: NOVELTY design.

ERJ Open Res 2019 Feb 1;5(1). Epub 2019 Feb 1.

School of Biological Sciences, University of Manchester, Manchester, UK.

Asthma and chronic obstructive pulmonary disease (COPD) have overlapping clinical features and share pathobiological mechanisms but are often considered distinct disorders. Prospective, observational studies across asthma, COPD and asthma-COPD overlap are limited. NOVELTY is a global, prospective observational 3-year study enrolling ∼12 000 patients ≥12 years of age from primary and specialist clinical practices in 19 countries (ClinicalTrials. Read More

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http://dx.doi.org/10.1183/23120541.00036-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355976PMC
February 2019
2 Reads

Clinical implications of blood pressure variability (BPV) in pregnancies: a review.

Horm Mol Biol Clin Investig 2019 Feb 4. Epub 2019 Feb 4.

Medical Sciences (Physiology), Universiti Sains Islam Malaysia, Kuala Lumpur, Malaysia, Phone: +603-4289 2400, Fax : +603-4289 2477.

Background Hypertension disorder in pregnancy (HDP) is the second most common contributor to maternal morbidity and mortality worldwide. Blood pressure variability (BPV), with the assistance of ambulatory blood pressure monitoring (ABPM), measures blood pressure readings in pregnant women and has the potential to predict the occurrence of pregnancy-induced hypertension (PIH) or preeclampsia (PE) before any symptoms develop. Methodology Studies involving ABPM among pregnant women were identified using electronic databases such as PubMed, Scopus, Google Scholar, ScienceDirect, Medscape, Ovid and ProQuest. Read More

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http://dx.doi.org/10.1515/hmbci-2018-0060DOI Listing
February 2019
1 Read

Instrument Selection Using the OMERACT Filter 2.1: The OMERACT Methodology.

J Rheumatol 2019 Feb 1. Epub 2019 Feb 1.

Institute for Work & Health and Institute for Health Policy Management and Evaluation, University of Toronto, Toronto ON Canada; Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, ON, Canada; Centre for Practice-Changing Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada; University of Ottawa, Ottawa, ON, Canada; Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada; Department of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands; Division of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds, UK; Hôpital Ambroise Paré, Rheumatology Department, 92100 Boulogne-Billancourt; INSERM U1173, Laboratoire d'Excellence INFLAMEX, UFR Simone Veil, Versailles-Saint-Quentin University, 78180 Saint-Quentin en Yvelines; France Department of Medical Humanities, Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands; Sorbonne Université, Paris France; Pitié Salpêtrière hospital, APHP, Rheumatology department, Paris, France; Sydney Medical School, Institute of Bone and Joint Research and Department of Rheumatology, Royal North Shore Hospital, St Leonards, Australia; Medicine Service, VA Medical Center, Birmingham, AL , USA; Department of Medicine, School of Medicine, University of Alabama, Birmingham, AL, USA; Division of Epidemiology, School of Public Health, University of Alabama, Birmingham, AL, USA SDG LLC, Cambridge, MA, USA; Division of Immunology/Rheumatology, Stanford University School of Medicine, Palo Alto CA, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health , Faculty of Medicine, University of Ottawa ; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. In kind support from Knowledge Transfer and Exchange team and the Measurement Sciences group at the Institute for Work & Health is acknowledged for the development of the OMERACT Way graphics and input into the methods used. PGC is funded in part by the National Institute of Health Research (NIHR) Leeds Biomedical Research Centre. This article presents independent research funded by the NIHR. The views expressed are those of the authors and not necessarily those of the National Health Services (NHS), the NIHR or the Department of Health. JAS has received consultant fees from Crealta/Horizon, Fidia, UBM LLC, Medscape, WebMD, the National Institutes of Health and the American College of Rheumatology. JAS is a member of the Veterans Affairs Rheumatology Field Advisory Committee. JAS is the editor and the Director of the University of Alabama Birmingham (UAB) Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS served as a member of the American College of Rheumatology's (ACR) Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. LMM is a Principal Investigator on the Australian Rheumatology Association Database that has received arms-length funding from 4 companies (Abbvie Australasia Ltd, Pfizer Australia, Janssen Australia, Eli Lilly Australia). PT is [unpaid] Chair of the Management SubCommittee of the Executive committee of a registered non-profit independent medical research organization, OMERACT, whose goal is to improve and advance the health outcomes for patients suffering from musculoskeletal conditions. OMERACT receives unrestricted educational grants from the American College of Rheumatology, European League of Rheumatology and several pharmaceutical companies listed below which is used to support fellows, international patient groups and support a major international biennial conference which results in many peer reviewed publications; Abbvie Amgen, Astra Zeneca, Bristol Myers Squibb, Celgene, Centrexion, EliLilly, Genentech/Roche, Gruenthal, Horizon Pharma Inc., Janssen, Novartis, Pfizer, Quintiles, UCB Group. PT is an independent Committee Member for clinical trial Data Safety Monitoring Boards for FDA approved trials for UCB Biopharma GmbH & SPRL, Parexel International, Prahealth Sciences and the Reformulary Group. PT is an advisory board member for the Canadian Reformulary Group Inc., a company that reviews the evidence for health insurance companies employer drug plans. Address correspondence to Dorcas Beaton BScOT, PhD, Senior Scientist, Institute for Work & Health, 481 University Avenue, Toronto, ON Canada. Email:

Objective: Outcome Measures in Rheumatology (OMERACT) Filter 2.1 revised the process used for core outcome measurement set selection to add rigour and transparency in decision making. This paper describes OMERACT's methodology for instrument selection. Read More

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http://dx.doi.org/10.3899/jrheum.181218DOI Listing
February 2019
1 Read

Adjunctive minocycline in schizophrenia: what one well-conducted study can tell us (and what it can't).

Evid Based Ment Health 2019 Feb 21;22(1):e3. Epub 2019 Jan 21.

Psychiatry Research, Northwell Health, Zucker Hillside Hospital, Glen Oaks, New York, USA.

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http://dx.doi.org/10.1136/ebmental-2018-300070DOI Listing
February 2019
1 Read

The Third Biennial 2018 OMERACT First-time Participant Program: A Qualitative and Quantitative Study.

J Rheumatol 2019 Jan 15. Epub 2019 Jan 15.

From the UCB Biosciences Inc., Raleigh, North Carolina; Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey; University of Alabama at Birmingham; Birmingham Veterans Affairs Medical Center, Birmingham, Alabama; Department of Orthopedics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA; OMERACT; University of Ottawa; Ottawa Heart Institute, Ottawa, Ontario, Canada. VSS is an employee of UCB Biosciences, Inc. JAS has received consultant fees from Crealta/Horizon, Fidia, UBM LLC, Medscape, WebMD, the National Institutes of Health and the American College of Rheumatology. JAS is a member of the Veterans Affairs Rheumatology Field Advisory Committee. JAS is the editor and the director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS served as a member of the American College of Rheumatology's (ACR) Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. JAS is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies. V.S. Sloan, MD, Clinical Associate Professor of Medicine, Rutgers-Robert Wood Johnson Medical School, and UCB Biosciences Inc.; S. Grosskleg, BS, Secretariat, OMERACT, and University of Ottawa; G. Wells, PhD, Professor of Medicine and Professor of Biostatistics, Ottawa Heart Institute, and University of Ottawa; J.A. Singh, MBBS, MPH, Professor of Medicine and Epidemiology, University of Alabama at Birmingham, and Staff Physician, Birmingham Veterans Affairs Medical Center, and Research Collaborator, Department of Orthopedics, Mayo Clinic College of Medicine. Address correspondence to Dr. J.A. Singh, University of Alabama, Faculty Office Tower 805B, 510 20th St. South, Birmingham, Alabama 35294, USA. E-mail: Accepted for publication November 14, 2018.

Objective: To assess the expanded/refined first-time participant training program.

Methods: We conducted a refined new participant program at OMERACT 2018 on days 1-4, in which first-time participants provided feedback with online surveys and a nominal group on Day 4.

Results: Twenty first-time participants attended the introductory session and 8-12 attended followup sessions. Read More

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http://dx.doi.org/10.3899/jrheum.181196DOI Listing
January 2019
1 Read

Effects of onabotulinumtoxinA treatment for chronic migraine on common comorbidities including depression and anxiety.

J Neurol Neurosurg Psychiatry 2019 Mar 10;90(3):353-360. Epub 2019 Jan 10.

Department of Neurology, Jefferson Headache Center, Philadelphia, Pennsylvania, USA.

Objective: To assess the effects of onabotulinumtoxinA treatment for chronic migraine (CM) on comorbid symptoms of depression, anxiety, fatigue and poor sleep quality.

Methods: The Chronic Migraine OnabotulinuMtoxinA Prolonged Efficacy open-Label (COMPEL) study is a multicentre, open-label, prospective study assessing the long-term safety and efficacy of onabotulinumtoxinA 155 U over nine treatments (108 weeks) in adults with CM. The Patient Health Questionnaire (PHQ-9) and Generalised Anxiety Disorder (GAD-7) scales were used to assess the effects of onabotulinumtoxinA on comorbid symptoms of depression and anxiety, respectively. Read More

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http://dx.doi.org/10.1136/jnnp-2018-319290DOI Listing
March 2019
1 Read

Racial Differences in Ischaemia/Bleeding Risk Trade-Off during Anti-Platelet Therapy: Individual Patient Level Landmark Meta-Analysis from Seven RCTs.

Thromb Haemost 2019 Jan 31;119(1):149-162. Epub 2018 Dec 31.

Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, Republic of Korea.

Background:  Prolonged dual anti-platelet therapy (DAPT) is intended to reduce ischaemic events, at the cost of an increased bleeding risk in patients undergoing percutaneous coronary intervention (PCI). In this study, we evaluated whether race influences the ischaemia/bleeding risk trade-off.

Methods:  We searched for randomized clinical trials (RCTs) comparing DAPT duration after PCI. Read More

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http://dx.doi.org/10.1055/s-0038-1676545DOI Listing
January 2019
3 Reads
4.984 Impact Factor

A multifactorial model of T cell expansion and durable clinical benefit in response to a PD-L1 inhibitor.

PLoS One 2018 31;13(12):e0208422. Epub 2018 Dec 31.

Microsoft Research New England, Cambridge, MA, United States of America.

Checkpoint inhibitor immunotherapies have had major success in treating patients with late-stage cancers, yet the minority of patients benefit. Mutation load and PD-L1 staining are leading biomarkers associated with response, but each is an imperfect predictor. A key challenge to predicting response is modeling the interaction between the tumor and immune system. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208422PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312275PMC
December 2018
1 Read

The role of thrombin in central nervous system activity and stroke.

Clujul Med 2018 Oct 30;91(4):368-371. Epub 2018 Oct 30.

Hematology Department, Faculty of Medicine, "Lucian Blaga" University of Sibiu, Romania.

Background: Thrombin is a key factor of hemostasis, mediating the conversion of fibrinogen into fibrin. Along with prothrombin, of which thrombin is the active derivative, it has been found locally expressed in the central nervous system. This article aims to describe the role of thrombin in the normal functioning of the central nervous system and stroke. Read More

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http://dx.doi.org/10.15386/cjmed-973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296729PMC
October 2018
1 Read

Pulmonary hypertension in chronic lung disease and hypoxia.

Eur Respir J 2019 Jan 24;53(1). Epub 2019 Jan 24.

University of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig University Giessen and Member of the German Center for Lung Research (DZL), Giessen, Germany.

Pulmonary hypertension (PH) frequently complicates the course of patients with various forms of chronic lung disease (CLD). CLD-associated PH (CLD-PH) is invariably associated with reduced functional ability, impaired quality of life, greater oxygen requirements and an increased risk of mortality. The aetiology of CLD-PH is complex and multifactorial, with differences in the pathogenic sequelae between the diverse forms of CLD. Read More

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http://dx.doi.org/10.1183/13993003.01914-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351338PMC
January 2019
1 Read

Risk stratification and medical therapy of pulmonary arterial hypertension.

Eur Respir J 2019 Jan 24;53(1). Epub 2019 Jan 24.

Cardiovascular Medicine, The University of Michigan, Ann Arbor, MI, USA.

Pulmonary arterial hypertension (PAH) remains a severe clinical condition despite the availability over the past 15 years of multiple drugs interfering with the endothelin, nitric oxide and prostacyclin pathways. The recent progress observed in medical therapy of PAH is not, therefore, related to the discovery of new pathways, but to the development of new strategies for combination therapy and on escalation of treatments based on systematic assessment of clinical response. The current treatment strategy is based on the severity of the newly diagnosed PAH patient as assessed by a multiparametric risk stratification approach. Read More

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http://dx.doi.org/10.1183/13993003.01889-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351343PMC
January 2019
11 Reads

Treatment-resistant and multi-therapy-resistant criteria for bipolar depression: consensus definition.

Br J Psychiatry 2019 Jan 6;214(1):27-35. Epub 2018 Dec 6.

Clinical Senior Lecturer in Mood Disorders and Consultant Psychiatrist,National Affective Disorders Service; Academic Psychiatry Training Programme Lead,Institute of Psychiatry,Psychology and Neuroscience,King's College London,South London and Maudsley NHS Foundation Trust (SLaM); andCRN South London Lead for Mental Health,Centre for Affective Disorders, Institute of Psychiatry,Psychology and Neuroscience,King's College London,South London and Maudsley NHS Foundation Trust (SLaM),UK.

Background: Most people with bipolar disorder spend a significant percentage of their lifetime experiencing either subsyndromal depressive symptoms or major depressive episodes, which contribute greatly to the high levels of disability and mortality associated with the disorder. Despite the importance of bipolar depression, there are only a small number of recognised treatment options available. Consecutive treatment failures can quickly exhaust these options leading to treatment-resistant bipolar depression (TRBD). Read More

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https://www.cambridge.org/core/product/identifier/S000712501
Publisher Site
http://dx.doi.org/10.1192/bjp.2018.257DOI Listing
January 2019
14 Reads

Effectiveness of healthcare educational and behavioral interventions to improve gout outcomes: a systematic review and meta-analysis.

Ther Adv Musculoskelet Dis 2018 Dec 19;10(12):235-252. Epub 2018 Nov 19.

Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham VA Medical Center, Faculty Office Tower 805B, 510 20th Street South, Birmingham, AL, 35294, USA.

Background: We aimed to systematically review the effectiveness of healthcare behavioral and education interventions for gout patients on clinical outcomes.

Methods: We searched multiple databases to identify trials or observational studies of educational or behavioral interventions in gout. Risk of bias was assessed with the Cochrane tool for randomized control trials (RCTs) and the Newcastle-Ottawa Scale for observational studies. Read More

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http://dx.doi.org/10.1177/1759720X18807117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262501PMC
December 2018
5 Reads

Analysis of the Patient Information Quality and Readability on Esophagogastroduodenoscopy (EGD) on the Internet.

Can J Gastroenterol Hepatol 2018 29;2018:2849390. Epub 2018 Oct 29.

Department of Medicine, Section of Digestive diseases, West Virginia University Hospitals, Morgantown, WV, USA.

Objective: Patients are increasingly using the Internet to inform themselves of health-related topics and procedures, including EGD. We analyzed the quality of information and readability of websites after a search on 3 different search engines.

Methods: We used an assessment tool for website quality analysis that we developed in addition to using validated instruments for website quality, Global Quality Score (GQS) and Health on Net (HON) certification. Read More

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https://www.hindawi.com/journals/cjgh/2018/2849390/
Publisher Site
http://dx.doi.org/10.1155/2018/2849390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231384PMC
October 2018
11 Reads

Obesity paradox on outcome in atrial fibrillation maintained even considering the prognostic influence of biomarkers: insights from the ARISTOTLE trial.

Open Heart 2018 1;5(2):e000908. Epub 2018 Nov 1.

Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.

Objective: We investigated the association between obesity and biomarkers indicating cardiac or renal dysfunction or inflammation and their interaction with obesity and outcomes.

Methods: A total of 14 753 patients in the Apixaban for Reduction In STroke and Other ThromboemboLic Events in Atrial Fibrillation (ARISTOTLE) trial provided plasma samples at randomisation to apixaban or warfarin. Median follow-up was 1. Read More

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http://dx.doi.org/10.1136/openhrt-2018-000908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242013PMC
November 2018
1 Read

Psychometric validation of the Perceived Deficits Questionnaire-Depression (PDQ-D) instrument in US and UK respondents with major depressive disorder.

Neuropsychiatr Dis Treat 2018 29;14:2861-2877. Epub 2018 Oct 29.

Global Outcomes Research, Lundbeck SAS, Issy-les-Moulineaux, France.

Background: Although depression and cognitive dysfunction are connected, limited tools exist to capture the patient's perspective on cognitive dysfunction and its impact on major depressive disorder (MDD). We report results of a psychometric validation of the Perceived Deficits Questionnaire-Depression (PDQ-D), a self-report measure of cognitive dysfunction for use in MDD.

Methods: A non-interventional, prospective, panel-recruited, online survey was conducted using the PDQ-D in adults with and without MDD in the US and UK. Read More

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http://dx.doi.org/10.2147/NDT.S175188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211374PMC
October 2018
9 Reads

Association of low income with pulmonary disease progression in smokers with and without chronic obstructive pulmonary disease.

ERJ Open Res 2018 Oct 12;4(4). Epub 2018 Nov 12.

Dept of Medicine, National Jewish Health, Denver, CO, USA.

Low socioeconomic status has been associated with chronic obstructive pulmonary disease (COPD) but little is known about its impact on disease progression. We assessed the association of income to symptoms, pulmonary disease severity and progression in smokers with and without COPD. The COPDGene cohort of 4826 smokers who reported annual income in phase 2 was analysed. Read More

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http://openres.ersjournals.com/lookup/doi/10.1183/23120541.0
Publisher Site
http://dx.doi.org/10.1183/23120541.00069-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230816PMC
October 2018
9 Reads

Tralokinumab did not demonstrate oral corticosteroid-sparing effects in severe asthma.

Eur Respir J 2019 Feb 31;53(2). Epub 2019 Jan 31.

AstraZeneca, Gaithersburg, MD, USA.

Long-term oral corticosteroid (OCS) use in patients with severe asthma is associated with significant adverse effects.This 40-week, randomised, double-blind trial evaluated the OCS-sparing potential of tralokinumab in patients with severe, uncontrolled asthma requiring maintenance OCS treatment plus inhaled corticosteroids/long-acting β-agonists. Overall, 140 patients were randomised to tralokinumab 300 mg or placebo (n=70 in each group) administered subcutaneously every 2 weeks. Read More

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http://dx.doi.org/10.1183/13993003.00948-2018DOI Listing
February 2019

Systemic sclerosis: state of the art on clinical practice guidelines.

RMD Open 2018 18;4(Suppl 1):e000782. Epub 2018 Oct 18.

Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy.

Systemic sclerosis (SSc) is an orphan disease characterised by autoimmunity, fibrosis of the skin and internal organs, and vasculopathy. SSc may be associated with high morbidity and mortality. In this narrative review we summarise the results of a systematic literature research, which was performed as part of the European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases project, aimed at evaluating existing clinical practice guidelines or recommendations. Read More

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http://rmdopen.bmj.com/lookup/doi/10.1136/rmdopen-2018-00078
Publisher Site
http://dx.doi.org/10.1136/rmdopen-2018-000782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203100PMC
October 2018
19 Reads

Provocative biomarker stress test: stress-delta N-terminal pro-B type natriuretic peptide.

Open Heart 2018 8;5(2):e000847. Epub 2018 Oct 8.

Division of Cardiology, Department of Medicine, Duke Clinical Research Institute, Durham, North Carolina, USA.

Objective: Stress testing is commonly performed in emergency department (ED) patients with suspected acute coronary syndrome (ACS). We hypothesised that changes in N-terminal pro-B type natriuretic peptide (NT-proBNP) concentrations from baseline to post-stress testing (stress-delta values) differentiate patients with ischaemic stress tests from controls.

Methods: We prospectively enrolled 320 adult patients with suspected ACS in an ED-based observation unit who were undergoing exercise stress echocardiography. Read More

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http://openheart.bmj.com/lookup/doi/10.1136/openhrt-2018-000
Publisher Site
http://dx.doi.org/10.1136/openhrt-2018-000847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196976PMC
October 2018
17 Reads

The acute efficacy of antipsychotics in schizophrenia: a review of recent meta-analyses.

Ther Adv Psychopharmacol 2018 Nov 8;8(11):303-318. Epub 2018 Oct 8.

The Zucker Hillside Hospital, Psychiatry Research, Glen Oaks, NY, USA Department of Psychiatry and Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, NY, USA Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany.

Schizophrenia is the eighth leading cause of disability worldwide in people aged 15-44 years. Before antidopaminergic antipsychotics were introduced in the 1950s, no effective medications existed for the treatment of schizophrenia. This review summarizes key meta-analytic findings regarding antipsychotic efficacy in the acute treatment of schizophrenia, including clozapine in treatment-resistant patients. Read More

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http://dx.doi.org/10.1177/2045125318781475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180374PMC
November 2018
10 Reads

Antibiotic resistance among bacterial conjunctival pathogens collected in the Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) surveillance study.

PLoS One 2018 18;13(10):e0205814. Epub 2018 Oct 18.

Bausch + Lomb, Rochester, New York, United States of America.

The Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) surveillance study evaluates in vitro antibiotic resistance among Staphylococcus aureus, coagulase-negative staphylococci (CoNS), Streptococcus pneumoniae, Pseudomonas aeruginosa, and Haemophilus influenzae isolates from ocular infections. Here we report resistance rates and trends among conjunctival-sourced ocular isolates collected across the US from 2009 through 2016. A total of 1198 conjunctival isolates (483 S. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205814PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193682PMC
October 2018
3 Reads

Women manifest more severe COPD symptoms across the life course.

Int J Chron Obstruct Pulmon Dis 2018;13:3021-3029. Epub 2018 Oct 1.

Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO, USA.

Background: Previous studies suggest that gender differences exist in COPD diagnosis and symptoms; these differences may be more pronounced in younger adults. Our objective was to explore age-associated gender differences across a range of COPD severities.

Materials And Methods: A total of 4,484 current and former smokers with COPD from the Genetic Epidemiology of COPD cohort were investigated using regression modeling to explore the association between gender, age, disease severity, and the contributing elements of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification system (symptoms, exacerbation risk, airflow limitation). Read More

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https://www.dovepress.com/women-manifest-more-severe-copd-sy
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http://dx.doi.org/10.2147/COPD.S160270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171761PMC
October 2018
8 Reads

Reliability of Sonoelastography in Ductal Carcinoma.

Ultrasound Med Biol 2019 01 8;45(1):21-25. Epub 2018 Oct 8.

University of Lahore, Lahore, Pakistan.

The objective of the study was to evaluate the reliability of sonoelastography in ductal carcinoma in patients in primary and secondary health care settings. Google Scholar, PubMed, Medline, Medscape, Wikipedia and NCBI were searched in January 2018 for all original research and review articles to identify relevant studies. Two reviewers selected the articles independently for based on the title and abstract. Read More

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http://dx.doi.org/10.1016/j.ultrasmedbio.2018.08.024DOI Listing
January 2019

Tapering Janus kinase inhibitors in rheumatoid arthritis with low disease activity or remission: reality or dream?

Ann Rheum Dis 2019 Feb 9;78(2):153-154. Epub 2018 Oct 9.

Medicine Service, Birmingham VA Medical Center, Birmingham, Alabama, USA

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21369
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http://dx.doi.org/10.1136/annrheumdis-2018-213694DOI Listing
February 2019
2 Reads

Assessment of Instrumental Activities of Daily Living in Older Adults with Subjective Cognitive Decline Using the Virtual Reality Functional Capacity Assessment Tool (VRFCAT).

J Prev Alzheimers Dis 2018 ;5(4):216-234

Alexandra S. Atkins, Ph.D., Vice President- Scientific Development, NeuroCog Trials, 3211 Shannon Road, Suite 300, Durham, NC 27707, USA, ph. (919) 401-4642, fx. (919) 401-4644, email:

Background: Continuing advances in the understanding of Alzheimer's disease progression have inspired development of disease-modifying therapeutics intended for use in preclinical populations. However, identification of clinically meaningful cognitive and functional outcomes for individuals who are, by definition, asymptomatic remains a significant challenge. Clinical trials for prevention and early intervention require measures with increased sensitivity to subtle deficits in instrumental activities of daily living (IADL) that comprise the first functional declines in prodromal disease. Read More

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http://www.jpreventionalzheimer.com/all-issues.html?article=
Publisher Site
http://dx.doi.org/10.14283/jpad.2018.28DOI Listing
January 2018
16 Reads

and progression of lung disease in children with cystic fibrosis.

Thorax 2019 Feb 1;74(2):125-131. Epub 2018 Oct 1.

School of Pharmacy, University of Queensland, Brisbane, Queensland, Australia.

Background: The impact of on lung disease in young children with cystic fibrosis is uncertain.

Aims: To determine if positive respiratory cultures of species are associated with: (1) increased structural lung injury at age 5 years; (2) accelerated lung function decline between ages 5 years and 14 years and (3) to identify explanatory variables.

Methods: A cross-sectional analysis of association between positive bronchoalveolar lavage (BAL) cultures and chest high-resolution CT (HRCT) scan findings at age 5 years in subjects from the Australasian Cystic Fibrosis Bronchoalveolar Lavage (ACFBAL) study was performed. Read More

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http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-2115
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http://dx.doi.org/10.1136/thoraxjnl-2018-211550DOI Listing
February 2019
18 Reads

A systematic review of clinical outcomes on the WHO Category II retreatment regimen for tuberculosis.

Int J Tuberc Lung Dis 2018 Oct;22(10):1127-1134

Liverpool School of Tropical Medicine, Liverpool, UK.

Objective: To assess the clinical outcomes of patients prescribed the World Health Organization (WHO) Category II retreatment regimen for tuberculosis (TB).

Design: A systematic review of the literature was performed by searching Medscape, Embase and Scopus databases for cohort studies and clinical trials reporting outcomes in adult patients on the Category II retreatment regimen.

Results: The proportion of patients successfully completing the retreatment regimen varied from 27% to 92% in the 39 studies included in this review. Read More

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http://dx.doi.org/10.5588/ijtld.17.0705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149242PMC
October 2018
1 Read

Diagnostic expansion in clinical trials: myocardial infarction, stroke, cancer recurrence, and metastases may not be the hard endpoints you thought they were.

BMJ 2018 Sep 19;362:k3783. Epub 2018 Sep 19.

Oregon Health Science University, Portland, Oregon, USA

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http://dx.doi.org/10.1136/bmj.k3783DOI Listing
September 2018
1 Read

Endophthalmitis rates among patients receiving intravitreal anti-VEGF injections: a USA claims analysis.

Clin Ophthalmol 2018 30;12:1625-1635. Epub 2018 Aug 30.

Genentech, Inc., South San Francisco, CA, USA.

Purpose: Intravitreal (IVT) injections of the anti-vascular endothelial growth factor (VEGF) agents aflibercept, bevacizumab, and ranibizumab are commonly prescribed to treat neovascular age-related macular degeneration (nAMD). Studies comparing inflammation rates in large populations of patients receiving these agents and the treatment of ocular inflammation post-IVT anti-VEGF injections are scarce. In this study, we compared rates of endophthalmitis claims (sterile and infectious) following IVT anti-VEGF injections to determine the risk factors associated with developing endophthalmitis, and examined the claims for subsequent treatment. Read More

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http://dx.doi.org/10.2147/OPTH.S169143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124467PMC

Effect of apixaban compared with warfarin on coagulation markers in atrial fibrillation.

Heart 2019 Feb 12;105(3):235-242. Epub 2018 Sep 12.

Uppsala Clinical Research Center (UCR), Uppsala University, Uppsala, Sweden.

Objectives: Compare the effect of apixaban and warfarin on coagulation and primary haemostasis biomarkers in atrial fibrillation (AF).

Methods: The biomarker substudy from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial included 4850 patients with AF randomised to treatment with apixaban or warfarin. Sixty per cent of patients used vitamin K antagonist (VKA) within 7 days before randomisation. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-313351DOI Listing
February 2019
22 Reads

Seasonal plasticity of cognition and related biological measures in adults with and without Alzheimer disease: Analysis of multiple cohorts.

PLoS Med 2018 Sep 4;15(9):e1002647. Epub 2018 Sep 4.

Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, New York, United States of America.

Background: There are few data concerning the association between season and cognition and its neurobiological correlates in older persons-effects with important translational and therapeutic implications for the diagnosis and treatment of Alzheimer disease (AD). We aimed to measure these effects.

Methods And Findings: We analyzed data from 3,353 participants from 3 observational community-based cohort studies of older persons (the Rush Memory and Aging Project [MAP], the Religious Orders Study [ROS], and the Minority Aging Research Study [MARS]) and 2 observational memory-clinic-based cohort studies (Centre de Neurologie Cognitive [CNC] study at Lariboisière Hospital and the Sunnybrook Dementia Study [SDS]). Read More

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http://dx.doi.org/10.1371/journal.pmed.1002647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122787PMC
September 2018
16 Reads

Assessment of internet sources on subungual melanoma.

Melanoma Res 2018 Aug 30. Epub 2018 Aug 30.

Department of Dermatology, Weill Cornell Medicine College, New York, New York, USA.

In this study, we sought to objectively determine the accuracy and comprehensibility of online material with regard to subungual melanoma, a nail disease that is rare within the general population, yet has high incidence in certain patient groups, and carries a poorer prognosis than other forms of cutaneous melanoma. Because improved prognosis relies on early diagnosis, the dissemination of accurate, understandable information is an important factor in patient education and health. Using a pro forma designed to score website reliability, the accountability, quality, readability, display, support features, and transparency of the most commonly listed search engine hits related to subungual melanoma were analyzed. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000508DOI Listing
August 2018
11 Reads

Exercise right heart catheterisation before and after pulmonary endarterectomy in patients with chronic thromboembolic disease.

Eur Respir J 2018 Sep 17;52(3). Epub 2018 Sep 17.

Dept of Thoracic Surgery, Kerckhoff Heart and Lung Center, Bad Nauheim, Germany.

Symptomatic patients with chronic thromboembolic disease (CTED) without pulmonary hypertension often show an excessive increase in mean pulmonary arterial pressure (MPAP) during exercise.We report on the impact of pulmonary endarterectomy (PEA) on pulmonary haemodynamics in a prospective series of 32 consecutive CTED patients who underwent PEA. All patients had a comprehensive diagnostic work-up including right heart catheterisation at baseline and 12 months after PEA. Read More

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http://dx.doi.org/10.1183/13993003.00458-2018DOI Listing
September 2018
6 Reads

Post hoc analyses of asenapine treatment in pediatric patients with bipolar I disorder: efficacy related to mixed or manic episode, stage of illness, and body weight.

Neuropsychiatr Dis Treat 2018 2;14:1941-1952. Epub 2018 Aug 2.

Toronto Western Research Institute, Toronto, ON, Canada.

Background: Patient characteristics and disease progression may affect response to pharmacologic intervention in bipolar I disorder. Asenapine is approved for acute treatment of manic/mixed episodes of bipolar I disorder in patients 10-17 years old. Post hoc analyses assessed asenapine efficacy in pediatric patients by current manic or mixed episode, number of lifetime episodes, and baseline body mass index (BMI). Read More

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http://dx.doi.org/10.2147/NDT.S165743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080865PMC
August 2018
4 Reads

Apixaban versus Dalteparin for the Treatment of Acute Venous Thromboembolism in Patients with Cancer: The Caravaggio Study.

Thromb Haemost 2018 Sep 13;118(9):1668-1678. Epub 2018 Aug 13.

Internal Medicine, S. Antonio Hospital, Padua, Italy.

International and national guidelines recommend low-molecular-weight heparin for the treatment of venous thromboembolism (VTE) in patients with cancer. The aim of the Caravaggio study is to assess whether oral apixaban is non-inferior to subcutaneous dalteparin for the treatment of acute proximal deep vein thrombosis and/or pulmonary embolism in patients with cancer. The study is an investigator-initiated, multi-national, prospective, randomized, open-label with blind end-point evaluation (PROBE), non-inferiority clinical trial (NCT03045406). Read More

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http://dx.doi.org/10.1055/s-0038-1668523DOI Listing
September 2018
22 Reads

Precision medicine in COPD: where are we and where do we need to go?

Eur Respir Rev 2018 Sep 1;27(149). Epub 2018 Aug 1.

Division of Pulmonary and Critical Care Medicine, Dept of Medicine, University of Michigan Health System, Ann Arbor, MI, USA.

Chronic obstructive pulmonary disease (COPD) was the fourth leading cause of death worldwide in 2015. Current treatments for patients ease discomfort and help decrease disease progression; however, none improve lung function or change mortality. COPD is heterogeneous in its molecular and clinical presentation, making it difficult to understand disease aetiology and define robust therapeutic strategies. Read More

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http://dx.doi.org/10.1183/16000617.0022-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156790PMC
September 2018
13 Reads

Clinical Impact of Bleeding in Cancer-Associated Venous Thromboembolism: Results from the Hokusai VTE Cancer Study.

Thromb Haemost 2018 Aug 30;118(8):1439-1449. Epub 2018 Jul 30.

University of Oklahoma Health Sciences Center, College of Public Health, University of Oklahoma, Oklahoma City, Oklahoma, United States.

In the Hokusai VTE Cancer study, edoxaban was non-inferior to dalteparin for the composite outcome of recurrent venous thromboembolism (VTE) and major bleeding in 1,050 patients with cancer-associated VTE. The absolute rate of recurrent VTE was 3.4% lower with edoxaban, whereas the absolute rate of major bleeding was 2. Read More

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http://dx.doi.org/10.1055/s-0038-1667001DOI Listing
August 2018
25 Reads

Leg Fracture Associated with Synostosis of Interosseous Membrane During Running in A Soccer Player.

Transl Med UniSa 2017 Jul 31;17:1-5. Epub 2018 Mar 31.

Department of Orthopaedics and Traumatology, University of Rome "Tor Vergata", Rome, Italy.

Introduction: Leg fractures may occur frequently in sport injuries but it is very rare to find this kind of injury associated with interosseous membrane synostosis. This case report describes a unique case of 42 B1.2 fracture of the leg associated with an interosseous membrane synostosis and literature review on Pubmed, Google scholar and Medscape. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056250PMC
July 2017
2 Reads

Clozapine and long-acting injectable antipsychotics reduce hospitalisation and treatment failure risk in patients with schizophrenia.

Evid Based Ment Health 2018 Aug 11;21(3):e11. Epub 2018 Jul 11.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Glen Oaks, New York, USA.

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http://dx.doi.org/10.1136/ebmental-2018-300003DOI Listing
August 2018
2 Reads

Occupation-associated health hazards for the gastroenterologist/endoscopist.

Ann Gastroenterol 2018 Jul-Aug;31(4):448-455. Epub 2018 Apr 27.

Eden Medical Center, Castro Valley, CA (Vishal Ghevariya), USA.

Advances in the field of endoscopy have allowed gastroenterologists to obtain detailed imaging of anatomical structures and to treat gastrointestinal diseases with endoscopic therapies. However, these technological developments have exposed endoscopists and staff to hazards such as musculoskeletal injuries, exposure to infectious agents, and ionizing radiation. We aimed to review the occupational hazards for the gastroenterologist and endoscopist. Read More

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http://www.annalsgastro.gr/files/journals/1/earlyview/2018/e
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http://dx.doi.org/10.20524/aog.2018.0265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033760PMC
April 2018
6 Reads

Has Rheumatology Become A More Attractive Career Choice? Comparison Of Trends In The Rheumatology Fellowship Match From 2008 To 2013 With 2014 To 2017.

Arthritis Care Res (Hoboken) 2018 Jun 28. Epub 2018 Jun 28.

Division of Rheumatology, Departments of Medicine, Keck School of Medicine, University of Southern California, and Los Angeles County + University of Southern California (LAC+USC) Medical Center, Los Angeles, California.

Objective: Rheumatology has been a less attractive career choice than other internal medicine (IM) subspecialties. Recent fellowship "Match" data suggested this may have changed. We therefore evaluated the current attractiveness of rheumatology and compared it with other medical subspecialties. Read More

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http://dx.doi.org/10.1002/acr.23691DOI Listing
June 2018
1 Read

Development and validation of a radiological diagnosis model for hypersensitivity pneumonitis.

Eur Respir J 2018 Aug 16;52(2). Epub 2018 Aug 16.

Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor, MI, USA.

High-resolution computed tomography (HRCT) may be useful for diagnosing hypersensitivity pneumonitis. Here, we develop and validate a radiological diagnosis model and model-based points score.Patients with interstitial lung disease seen at the University of Michigan Health System (derivation cohort) or enrolling in the Lung Tissue Research Consortium (validation cohort) were included. Read More

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http://dx.doi.org/10.1183/13993003.00443-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181129PMC
August 2018
30 Reads

Can CAPTURE be used to identify undiagnosed patients with mild-to-moderate COPD likely to benefit from treatment?

Int J Chron Obstruct Pulmon Dis 2018 13;13:1901-1912. Epub 2018 Jun 13.

University of Minnesota, Department of Family & Community Health, Minneapolis, MN & COPD Foundation, Miami, FL, USA.

Background: COPD Assessment in Primary Care To Identify Undiagnosed Respiratory Disease and Exacerbation Risk (CAPTURE™) uses five questions and peak expiratory flow (PEF) thresholds (males ≤350 L/min; females ≤250 L/min) to identify patients with a forced expiratory volume in 1 second (FEV)/forced vital capacity (FVC) <0.70 and FEV <60% predicted or exacerbation risk requiring further evaluation for COPD. This study tested CAPTURE's ability to identify symptomatic patients with mild-to-moderate COPD (FEV 60%-80% predicted) who may also benefit from diagnosis and treatment. Read More

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http://dx.doi.org/10.2147/COPD.S152226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005334PMC
January 2019
16 Reads

Non-vitamin K Antagonist Oral Anticoagulant After Acute Coronary Syndrome: Is There a Role?

Interv Cardiol 2018 May;13(2):93-98

Icahn School of Medicine, Mount Sinai Hospital, New York NY, USA.

Despite dual antiplatelet therapy (DAPT) including potent P2Y12 inhibitors, recurrent ischaemic events occur in a significant number of patients after acute coronary syndrome (ACS), warranting new antithrombotic strategies. Combinations of non-vitamin K antagonist oral anticoagulant (NOAC) with antiplatelet therapy have been tested in several large phases II and III randomised trials. Overall, current evidence suggests that the use of NOACs on top of DAPT after ACS reduces the rate of recurrent ischaemic events, albeit at the price of increased risk for major bleeding. Read More

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https://www.icrjournal.com/articles/non-vitamin-k-antagonist
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http://dx.doi.org/10.15420/icr.2018:5:2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980653PMC
May 2018
5 Reads

Initiating/maintaining long-acting injectable antipsychotics in schizophrenia/schizoaffective or bipolar disorder - expert consensus survey part 2.

Neuropsychiatr Dis Treat 2018 8;14:1475-1492. Epub 2018 Jun 8.

Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY, USA.

Objective: The aim of this study was to provide recommendations on initiating and maintaining long-acting injectable antipsychotics (LAIs) in individuals with schizophrenia/schizoaffective or bipolar disorder.

Methods: A 50-question survey comprising 916 response options was completed by 34 expert researchers and high prescribers with extensive LAI experience, rating relative appropriateness/importance on a 9-point scale. Consensus was determined using chi-square test of score distributions. Read More

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http://dx.doi.org/10.2147/NDT.S167485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997122PMC
June 2018
5 Reads

Identifying patients and clinical scenarios for use of long-acting injectable antipsychotics - expert consensus survey part 1.

Neuropsychiatr Dis Treat 2018 8;14:1463-1474. Epub 2018 Jun 8.

Cell Biology and Neuroscience, Center for Mental Health Research and Recovery, Montana State University, Bozeman, MT, USA.

Objective: To assess expert consensus on barriers and facilitators for long-acting injectable antipsychotic (LAI) use and provide clinical recommendations on issues where clinical evidence is lacking, including identifying appropriate clinical situations for LAI use.

Methods: A 50-question survey comprising 916 response options was distributed to 42 research experts and high prescribers with extensive LAI experience. Respondents rated options on relative appropriateness/importance using a 9-point scale. Read More

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http://dx.doi.org/10.2147/NDT.S167394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997124PMC
June 2018
5 Reads

Cancer risk in HIV patients with incomplete viral suppression after initiation of antiretroviral therapy.

PLoS One 2018 5;13(6):e0197665. Epub 2018 Jun 5.

Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

Background: Cancer causes significant morbidity and mortality among HIV patients in the US due to extended life expectancy with access to effective antiretroviral therapy. Low, detectable HIV RNA has been studied as a risk factor for adverse health outcomes, but its clinical impact on cancer risk remains unclear. The objective of this study was to determine whether HIV RNA <1,000 copies/mL six months after starting therapy was associated with 10-year first cancer risk. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197665PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988275PMC
November 2018
11 Reads