57,190 results match your criteria Medizinische Klinik Munich Germany : 1983[Journal]


Posttranslational modifications and proteinopathies: how guardians of the proteome are defeated.

Authors:
Heidi Olzscha

Biol Chem 2018 Dec 1. Epub 2018 Dec 1.

Institut für Physiologische Chemie, Medizinische Fakultät, Martin-Luther-Universität Halle- Wittenberg, Hollystr. 1, D-06114 Halle/Saale, Germany.

Protein folding is one of the fundamental processes in life, and therefore needs to be tightly regulated. Many cellular quality control systems are in place to ensure that proteostasis is optimally adjusted for a changing environment, facilitating protein folding, translocation and degradation. These systems include the molecular chaperones and the major protein degradation systems, namely the ubiquitin proteasome system and autophagy. Read More

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http://dx.doi.org/10.1515/hsz-2018-0458DOI Listing
December 2018

Development of Automated Separation, Expansion and Quality Control Protocols for Clinical-Scale Manufacturing of Primary Human NK Cells and Alpharetroviral CAR Engineering.

Hum Gene Ther Methods 2019 Apr 18. Epub 2019 Apr 18.

Medizinische Hochschule Hannover, 9177, Institute for Cellular Therapeutics, Hannover, Niedersachsen, Germany.

In cellular immunotherapies, natural killer (NK) cells often demonstrate potent antitumor effects in high-risk cancer patients. But GMP-compliant manufacturing of clinical-grade NK cells in high numbers for patient treatment is still a challenge. Therefore, new protocols for isolation and expansion of NK cells are required. Read More

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http://dx.doi.org/10.1089/hgtb.2019.039DOI Listing

[Complications in sutured scleral fixation of artificial lens implantation].

Ophthalmologe 2019 Apr 17. Epub 2019 Apr 17.

Klinik für Augenheilkunde, Universitätsmedizin Göttingen, Göttingen, Deutschland.

Background: Sutured scleral fixation of an artificial posterior chamber lens is a frequently used method for the treatment of eyes with poor or absent capsular support; however, the complication profile is often considered unfavorable.

Objective: To analyze the postoperative complication profile.

Methods: In this monocentric and retrospective analysis of a consecutive case series of patients with standardized sutured scleral fixation of a posterior chamber lens between 2007 and 2017, the documented complications were categorized as a permanent threat to visual acuity, such as endophthalmitis, choroidal hemorrhage, retinal detachment and clinically relevant but without a permanent threat to visual acuity, such as hemorrhage and hypotension. Read More

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http://dx.doi.org/10.1007/s00347-019-0896-0DOI Listing

[Training modules on climate change, heat, and health for medical assistants and nurses in outpatient care].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2019 Apr 17. Epub 2019 Apr 17.

Institut und Poliklinik für Arbeits‑, Sozial- und Umweltmedizin, Klinikum der Universität München, LMU München, Ziemssenstraße 1, 80336, München, Deutschland.

The number of heatwaves is going to increase due to climate change and will pose a high health risk especially for elderly people. Additional risk factors like immobility, the need for care, chronic and acute diseases (worsening of symptoms), and the intake of medications lead to an increased sensitivity to heat in this particular age group. Nursing staff and medical assistants working in general practices are two important professions to reach the risk group during heatwaves and provide preventive and curative care. Read More

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http://dx.doi.org/10.1007/s00103-019-02942-wDOI Listing

Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells.

ACS Med Chem Lett 2019 Apr 28;10(4):511-516. Epub 2019 Jan 28.

School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, via S. Agostino 1, 62032 Camerino, Italy.

The potent -methyl-d-aspartate (NMDA) receptor antagonists - have been demonstrated to show antiproliferative and cytotoxic effects in MCF-7 and SKBR3 breast cancer cell lines. To improve the knowledge about the role played by the NMDA receptor in the antitumor activity of these compounds, the enantiomers of were prepared and evaluated for their affinity for the phencyclidine (PCP) site of the NMDA receptor and for their cytotoxic effect in MCF-7 and SKBR3 cell lines, both expressing the NMDA receptor. The ()- enantiomer, showing negligible affinity for the PCP site, exhibited antiproliferative activity higher than that of ()-, which instead bound the PCP site. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466546PMC

Serial ankle casts for patients with idiopathic toe walking: effects on functional gait parameters.

J Child Orthop 2019 Apr;13(2):147-154

University Center for Orthopaedics and Trauma Surgery, Carl Gustav Carus University Hospital, Technical University of Dresden, Dresden, Germany.

Purpose: The aim of the present study was to investigate the functional effects on gait parameters of serial ankle casts for patients with idiopathic toe walking (ITW), in comparison with an unremarkable control group.

Methods: A prospective trial with a pre-test-post-test control group design included ten patients with ITW and ten healthy matched children. Children with ITW underwent serial casting to stretch the plantar flexors, with two 14-day periods with walking plaster casts set at the maximum available ankle dorsiflexion. Read More

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http://dx.doi.org/10.1302/1863-2548.13.180183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442509PMC

Thrombin: A Gas Pedal Driving Innate Immunity.

Immunity 2019 Apr;50(4):1024-1026

Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. Electronic address:

Hemostasis and immunity were long considered entirely separate entities. In this issue of Immunity, Burzynski et al. (2019) find that thrombin, the key enzyme within the coagulation cascade, activates IL-1α, a central pleiotropic pro-inflammatory cytokine, to promote wound healing and platelet production following ectoderm injury. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193009
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http://dx.doi.org/10.1016/j.immuni.2019.03.006DOI Listing
April 2019
1 Read

Erratum zu: Warum brauchen wir Cardiac-Arrest-Zentren?

Herz 2019 Apr 16. Epub 2019 Apr 16.

Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Köln (AöR), Kerpener Straße 62, 50937, Köln, Deutschland.

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http://dx.doi.org/10.1007/s00059-019-4804-9DOI Listing

Long-term prognostic utility of computed tomography coronary angiography in older populations.

Eur Heart J Cardiovasc Imaging 2019 Apr 16. Epub 2019 Apr 16.

Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medicine, New York, NY, USA.

Aims: The long-term prognostic value of coronary computed tomography angiography (CCTA)-identified coronary artery disease (CAD) has not been evaluated in elderly patients (≥70 years). We compared the ability of coronary CCTA to predict 5-year mortality in older vs. younger populations. Read More

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https://academic.oup.com/ehjcimaging/advance-article/doi/10.
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http://dx.doi.org/10.1093/ehjci/jez067DOI Listing
April 2019
1 Read

Novel antimicrobial coatings based on polylactide for plastic biliary stents to prevent post-endoscopic retrograde cholangiography cholangitis.

J Antimicrob Chemother 2019 Apr 16. Epub 2019 Apr 16.

Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar der Technischen Universität München, München, Germany.

Background: Cholangitis is a common complication after endoscopic retrograde cholangiography (ERC).

Objectives: To evaluate antimicrobial coatings for biliary plastic stents in relation to efficacy against biliary pathogens, drug release and toxicity.

Methods: Biliary plastic stents were prepared by coating using a polylactide drug carrier. Read More

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http://dx.doi.org/10.1093/jac/dkz128DOI Listing

Patient safety during final-year clerkships: A qualitative study of possible error sources and of the potential of Entrustable Professional Activities.

GMS J Med Educ 2019 15;36(2):Doc18. Epub 2019 Mar 15.

Charité - Universitätsmedizin Berlin, Dieter Scheffner Fachzentrum für medizinische Hochschullehre und Ausbildungsforschung, Prodekanat für Studium und Lehre, Berlin, Germany.

In final-year clerkships, such as the Practical Year in Germany, students' workplace learning has to be balanced with the ensuring of patient safety. In this qualitative study, we investigated problems concerning patient safety as perceived from the perspective of supervising physicians, and whether and to what extent Entrustable Professional Activities (EPAs) can lead to an improvement in patient safety. Data was collected through focus groups. Read More

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http://dx.doi.org/10.3205/zma001226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446462PMC

"Hopefully, I will never forget that again" - sensitizing medical students for drug safety by working on cases and simulating doctor-patient communication.

GMS J Med Educ 2019 15;36(2):Doc17. Epub 2019 Mar 15.

Universität zu Köln, Zentrum für Pharmakologie, Köln, Germany.

This project is part of the "PJ-STArT-Block", a one-week course preparing 10 semester medical students for their final practical year. The focus is on sensitizing students to aspects of medication safety by becoming aware of their skills and their deficits in terms of application and communication of pharmacological knowledge. The modules were evaluated regarding feasibility, acceptance and possible effects. Read More

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http://dx.doi.org/10.3205/zma001225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446464PMC

Patient safety - Development, implementation and evaluation of an interprofessional teaching concept.

GMS J Med Educ 2019 15;36(2):Doc13. Epub 2019 Mar 15.

BG Unfallklinik Ludwigshafen, Centrum für interdisziplinäre Rettungs- und Notfallmedizin, Ludwigshafen, Germany.

Patient safety has high priority in health care. Since successful interprofessional collaboration is essential for patient safety, the topic should ideally be addressed interprofessionally in the curricula. The aim of the project was the development and implementation of an interprofessional teaching concept "patient safety" for medical students and students of health professions at the Medical Faculty Heidelberg. Read More

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http://www.egms.de/en/journals/zma/2019-36/zma001221.shtml
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http://dx.doi.org/10.3205/zma001221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446471PMC
March 2019
1 Read

[Breathing: Ambient Air Pollution and Health - Part I].

Pneumologie 2019 Apr 16. Epub 2019 Apr 16.

Heinrich-Heine-Universität Düsseldorf, Medizinische Fakultät, Institut für Arbeits-, Sozial- und Umweltmedizin, Düsseldorf.

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http://dx.doi.org/10.1055/a-0882-9366DOI Listing

Clinical Ultrasound in Inflammatory Bowel Disease.

Ultraschall Med 2019 Apr 16;40(2):132-162. Epub 2019 Apr 16.

Internal Medicine, Städtisches Klinikum Lüneburg gGmbH, Lüneburg, Germany.

Ultrasound should be the first-line imaging method in the medical care of patients with inflammatory bowel disease. It can be used to differentiate between Crohn's disease and ulcerative colitis and to detect numerous complications like stenoses, fistulas, and abscesses. As the method is also highly suitable for follow-up, stressful endoscopic procedures and examinations involving radiation are less necessary. Read More

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http://dx.doi.org/10.1055/a-0869-8799DOI Listing

Significance Tests for Boosted Location and Scale Models with Linear Base-Learners.

Int J Biostat 2019 Apr 16. Epub 2019 Apr 16.

Institut für medizinische Biometrie, Informatik und Epidemiologie, Medizinische Fakultät, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.

Generalized additive models for location scale and shape (GAMLSS) offer very flexible solutions to a wide range of statistical analysis problems, but can be challenging in terms of proper model specification. This complex task can be simplified using regularization techniques such as gradient boosting algorithms, but the estimates derived from such models are shrunken towards zero and it is consequently not straightforward to calculate proper confidence intervals or test statistics. In this article, we propose two strategies to obtain p-values for linear effect estimates for Gaussian location and scale models based on permutation tests and a parametric bootstrap approach. Read More

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http://www.degruyter.com/view/j/ijb.ahead-of-print/ijb-2018-
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http://dx.doi.org/10.1515/ijb-2018-0110DOI Listing
April 2019
1 Read

Clinical outcomes of robot-assisted radical cystectomy and continent urinary diversion.

Scand J Urol 2019 Apr 16:1-8. Epub 2019 Apr 16.

a Department of Molecular Medicine and Surgery, Section of Urology , Karolinska Institut , Stockholm , Sweden.

Robot-assisted radical cystectomy (RARC) with intracorporeal orthotopic neobladder (ONB) can be recognized to be the supreme discipline in urological pelvic surgery. The utilization of RARC with intracorporeal urinary diversion (ICUD) has increased during the last 15 years. This increase is primarily noted for ICUD with ileal conduits, but with a lesser extent also for IC neobladders, with an increase from 7% in 2005 to 17% in 2016. Read More

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https://www.tandfonline.com/doi/full/10.1080/21681805.2019.1
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http://dx.doi.org/10.1080/21681805.2019.1598486DOI Listing
April 2019
2 Reads

Heart failure in cardiomyopathies: a position paper from the Heart Failure Association of the European Society of Cardiology.

Eur J Heart Fail 2019 Apr 16. Epub 2019 Apr 16.

Berlin-Brandenburg Center for Regenerative Therapies, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) Berlin, Department of Cardiology, Campus Virchow Klinikum, Charite - Universitaetsmedizin Berlin, Berlin, Germany.

Cardiomyopathies are a heterogeneous group of heart muscle diseases and an important cause of heart failure (HF). Current knowledge on incidence, pathophysiology and natural history of HF in cardiomyopathies is limited, and distinct features of their therapeutic responses have not been systematically addressed. Therefore, this position paper focuses on epidemiology, pathophysiology, natural history and latest developments in treatment of HF in patients with dilated (DCM), hypertrophic (HCM) and restrictive (RCM) cardiomyopathies. Read More

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http://dx.doi.org/10.1002/ejhf.1461DOI Listing
April 2019
6.526 Impact Factor

[Hypertension - what the new guidelines say].

Authors:
Bernhard Krämer

MMW Fortschr Med 2019 Apr;161(7):65-70

Universitätsmedizin Mannheim, Medizinische Fakultät Mannheim der Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68176, Mannheim, Deutschland.

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https://www.springermedizin.de/doi/10.1007/s15006-019-0410-2
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http://dx.doi.org/10.1007/s15006-019-0410-2DOI Listing
April 2019
1 Read

[Intracranial hemorrhage masquerading as STEMI].

Med Klin Intensivmed Notfmed 2019 Apr 15. Epub 2019 Apr 15.

Allgemeine Intensivstation, Universitätsklinik für Innere Medizin, Medizinische Universität Graz, Auenbruggerplatz 15, 8036, Graz, Österreich.

A 56-year-old woman was found unconscious and promptly intubated. The electrocardiogram showed ST elevations in I, aVL, V1-V4. Thus, lysis therapy was performed. Read More

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http://dx.doi.org/10.1007/s00063-019-0584-5DOI Listing

[An 83-year-old woman with anesthesia-linked hepatitis : Preparation for the medical specialist examination: part 10].

Authors:
A R Heller

Anaesthesist 2019 Apr;68(Suppl 2):123-126

Klinik für Anästhesiologie und operative Intensivmedizin, Medizinische Fakultät der Universität Augsburg, Stenglinstraße 2, 86156, Augsburg, Deutschland.

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http://dx.doi.org/10.1007/s00101-018-0467-9DOI Listing

[72-years-old male with known COPD and lactatacidosis : Preparation for the medical specialist examination: Part 17].

Authors:
P Deetjen

Anaesthesist 2019 Apr;68(Suppl 2):154-157

Klinik für Anästhesiologie und operative Intensivmedizin, Medizinische Fakultät, Universität Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.

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http://dx.doi.org/10.1007/s00101-019-0542-xDOI Listing

[67-year-old male in resuscitation room for treatment after traffic accident : Preparation for the medical specialist examination: Part 7].

Authors:
C Dumps D Bolkenius

Anaesthesist 2019 Apr;68(Suppl 2):107-112

Klinik für Anästhesiologie und Operative Intensivmedizin, Medizinische Fakultät der Universität Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.

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http://dx.doi.org/10.1007/s00101-018-0520-8DOI Listing

Purification-independent immunoreagents obtained by displaying nanobodies on bacteria surface.

Appl Microbiol Biotechnol 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Environmental and Life Sciences, University of Nova Gorica, Vipavska cesta 13, SI-5000, Rožna Dolina, Nova Gorica, Slovenia.

The availability of preimmune libraries of antibody fragments allows for the fast generation of binders which can be expressed in both eukaryotic and prokaryotic systems. We exploited the recombinant nature of antibody fragments to demonstrate the possibility of expressing them as functional proteins displayed on the surface of Escherichia coli and by such a way to generate living reagents ready-to-use for diagnostics. Such immunoreagents were effectively exploited without the necessity of any purification step to prepare immunocapture surfaces suitable for the diagnostic of both cancer cells and toxic microalgae. Read More

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http://dx.doi.org/10.1007/s00253-019-09823-xDOI Listing

[Real World Management of Gouty Arthritis: Clinical, Epidemiological and Comorbidity Data from 4016 Patients in Rhineland-Palatinate, Germany].

Dtsch Med Wochenschr 2019 Apr 15;144(8):e51-e57. Epub 2019 Apr 15.

ACURA Rheuma-Kliniken, Bad Kreuznach, Deutschland.

Background:  To examine clinical, comorbidity and demographic aspects of gout and to explore the routine clinical practice of gout treatment among general practitioners (G.P.'s) in southwest Germany. Read More

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http://dx.doi.org/10.1055/a-0755-1341DOI Listing

Azithromycin, the Holy Grail to Prevent Exacerbations in Chronic Respiratory Disease.

Authors:
Tobias Welte

Am J Respir Crit Care Med 2019 Apr 15. Epub 2019 Apr 15.

Medizinische Hochschule Hannover, Direktor der Abteilung Pneumologie, Hannover, Germany ;

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http://dx.doi.org/10.1164/rccm.201903-0706EDDOI Listing

Magnetic resonance imaging abnormalities in the basal interventricular septum of patients with left ventricular outflow tract arrhythmias.

J Cardiovasc Electrophysiol 2019 Apr 14. Epub 2019 Apr 14.

Medizinische Klinik 1, HELIOS Klinikum München-West, Akademisches Lehrkrankenhaus der Universität München, Germany.

Introduction: Concealed structural abnormalities were detected by delayed enhancement - magnetic resonance imaging (DE-MRI) in patients with apparently idiopathic tachycardia of left ventricular (LV) origin. Basal septal fibrosis was evaluated as a potential arrhythmia substrate in patients with left ventricular outflow tract (LVOT) arrhythmias.

Methods And Results: 22 patients with LVOT arrhythmias, including frequent monomorphic premature ventricular complexes (PVCs) in 15 patients and ventricular tachycardia (VT) in 7 patients, underwent catheter ablation and DE-MRI. Read More

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http://dx.doi.org/10.1111/jce.13951DOI Listing

Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial.

Lancet 2019 Apr 10. Epub 2019 Apr 10.

Tagestherapiezentrum am ITM, III. Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany.

Background: Docetaxel-based chemotherapy is effective in metastatic gastric and gastro-oesophageal junction adenocarcinoma. This study reports on the safety and efficacy of the docetaxel-based triplet FLOT (fluorouracil plus leucovorin, oxaliplatin and docetaxel) as a perioperative therapy for patients with locally advanced, resectable tumours.

Methods: In this controlled, open-label, phase 2/3 trial, we randomly assigned 716 patients with histologically-confirmed advanced clinical stage cT2 or higher or nodal positive stage (cN+), or both, resectable tumours, with no evidence of distant metastases, via central interactive web-based-response system, to receive either three pre-operative and three postoperative 3-week cycles of 50 mg/m epirubicin and 60 mg/m cisplatin on day 1 plus either 200 mg/m fluorouracil as continuous intravenous infusion or 1250 mg/m capecitabine orally on days 1 to 21 (ECF/ECX; control group) or four preoperative and four postoperative 2-week cycles of 50 mg/m docetaxel, 85 mg/m oxaliplatin, 200 mg/m leucovorin and 2600 mg/m fluorouracil as 24-h infusion on day 1 (FLOT; experimental group). Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32557-1DOI Listing

Pathogenic Variants in GPC4 Cause Keipert Syndrome.

Am J Hum Genet 2019 Apr 5. Epub 2019 Apr 5.

Murdoch Children's Research Institute, Flemington Road, Parkville, Victoria 3052, Australia; Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia. Electronic address:

Glypicans are a family of cell-surface heparan sulfate proteoglycans that regulate growth-factor signaling during development and are thought to play a role in the regulation of morphogenesis. Whole-exome sequencing of the Australian family that defined Keipert syndrome (nasodigitoacoustic syndrome) identified a hemizygous truncating variant in the gene encoding glypican 4 (GPC4). This variant, located in the final exon of GPC4, results in premature termination of the protein 51 amino acid residues prior to the stop codon, and in concomitant loss of functionally important N-linked glycosylation (Asn514) and glycosylphosphatidylinositol (GPI) anchor (Ser529) sites. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029297193007
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http://dx.doi.org/10.1016/j.ajhg.2019.02.026DOI Listing
April 2019
1 Read

Predictors of response and remission in a naturalistic inpatient sample undergoing multimodal treatment for depression.

J Affect Disord 2019 Apr 8;252:99-106. Epub 2019 Apr 8.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany.

Background: Many depressed patients do not achieve response or remission despite adequate treatment. Identifying predictors of outcome can contribute to developing therapeutic algorithms for difficult-to-treat depression. Therefore, we examined clinical predictors of response and remission in a naturalistic inpatient sample undergoing multimodal treatment for depression. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.044DOI Listing

Bendamustine for patients with indolent B cell lymphoproliferative malignancies including chronic lymphocytic leukaemia - an updated meta-analysis.

Br J Haematol 2019 Apr 13. Epub 2019 Apr 13.

Tel Aviv University, Tel Aviv.

The question of which chemotherapy induction provides the best results for indolent lymphoma patients is yet unanswered. Different regimens have been compared, none of which has been shown to improve overall survival. The use of bendamustine is growing. Read More

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http://dx.doi.org/10.1111/bjh.15901DOI Listing
April 2019
2 Reads

[Erratum to: Simulation training as part of clinical riskmanagement : A health economic view].

Anaesthesist 2019 Apr 12. Epub 2019 Apr 12.

Klinik für Anästhesiologie, Intensivmedizin, Schmerztherapie, und Notfallmedizin, Krankenhaus Düren gem. GmbH, Roonstraße 30, 52351, Düren, Deutschland.

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http://dx.doi.org/10.1007/s00101-019-0591-1DOI Listing

[Treatment of hyperglycemia in adult, critically ill patients (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Abteilung für Innere Medizin, Privatklinik Wehrle-Diakonissen, Salzburg, Österreich.

In critical illness hyperglycemia is associated with increased mortality. Based on the currently available evidence, an intravenous insulin therapy should be initiated when blood glucose is above 180 mg/dl. After initiation of insulin therapy blood glucose should be maintained between 140 and 180 mg/dl. Read More

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http://link.springer.com/10.1007/s00508-019-1486-5
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http://dx.doi.org/10.1007/s00508-019-1486-5DOI Listing
April 2019
2 Reads

[Geriatric aspects for the management of diabetes mellitus (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Medizinische Abteilung für Endokrinologie, Rheumatologie und Akutgeriatrie, Wilhelminenspital der Stadt Wien, Wien, Österreich.

There is a high prevalence of diabetes mellitus in the elderly population of industrial countries. The present article provides recommendations for the screening, prevention and treatment of elderly diabetic patients according to current scientific evidence. Read More

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http://link.springer.com/10.1007/s00508-019-1463-z
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http://dx.doi.org/10.1007/s00508-019-1463-zDOI Listing
April 2019
3 Reads

[CGM-Continuous Glucose Monitoring-Statement of the Austrian Diabetes Association (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Abteilung für Innere Medizin, Privatklinik Wehrle-Diakonissen, Salzburg, Österreich.

This position statement represents the recommendations of the Austrian Diabetes Association regarding the clinical diagnostic and therapeutic application, safety and benefits of continuous subcutaneous glucose monitoring systems in patients with diabetes, based on current evidence. Read More

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http://link.springer.com/10.1007/s00508-019-1465-x
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http://dx.doi.org/10.1007/s00508-019-1465-xDOI Listing
April 2019
2 Reads

[Nutrition for diabetic patients (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

1. Medizinische Abteilung mit Diabetologie, Endokrinologie und Nephrologie, Krankenanstalt Rudolfstiftung, Wien, Österreich.

Evidence demonstrates that medical diabetes treatment has to be accompanied by lifestyle modifications. Structured nutrition interventions and increased physical activity will help patients to normalise, respectively maintain their body weight.The main target of a medical nutrition therapy aims at achieving normal or nearly normal blood glucose levels, prevention of delay of diabetes associated complications. Read More

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http://link.springer.com/10.1007/s00508-019-1470-0
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http://dx.doi.org/10.1007/s00508-019-1470-0DOI Listing
April 2019
1 Read

[Position statement: surgery and diabetes mellitus (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

1. Medizinische Abteilung für Diabetologie, Endokrinologie und Nephrologie, Krankenanstalt Rudolfstiftung, Wien, Österreich.

This position statement reflects the opinion of the Austrian Diabetes Association concerning the perioperative management of patients with diabetes mellitus based on the available scientific evidence. The paper covers necessary preoperative examinations from an internal/diabetological point of view as well as the perioperative metabolic control by means of oral antidiabetics and/or insulin therapy. Read More

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http://dx.doi.org/10.1007/s00508-019-1459-8DOI Listing

[Mental disorders and diabetes mellitus (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Klinische Abteilung für Endokrinologie und Diabetologie, Universitätsklinik für Innere Medizin, Medizinische Universität Graz, Graz, Österreich.

Psychiatric disorders and psychological problems are common in patients with diabetes mellitus. There is a twofold increase in depression which is associated with suboptimal glycemic control and increased morbidity and mortality. Other psychiatric disorders with a higher incidence of diabetes mellitus are cognitive impairment, dementia, disturbed eating behavior, anxiety disorders, schizophrenia, bipolar disorders and borderline personality disorder. Read More

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http://dx.doi.org/10.1007/s00508-019-1458-9DOI Listing

[Diagnosis and management of patients with diabetes and co-existing osteoporosis (Update 2019) : Common guideline of the Autrian Society for Bone and Mineral Research and the Austrian Diabetes Society].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Externe Lehre, Medizinische Universität Wien, Wien, Österreich.

Fragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. The identification and management of fracture risk in these patients remains challenging. This manuscript explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies that have evaluated areal bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction algorithms (FRAX) in these patients. Read More

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http://dx.doi.org/10.1007/s00508-019-1462-0DOI Listing

[Lifestyle: physical activity and training as prevetion and therapy of type 2 diabetes mellitus (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Österreichische Gesellschaft für Public Health, Wien, Österreich.

Lifestyle in general and particularly health enhancing physical activity is known to be an important component in the prevention and therapy of type 2 diabetes mellitus.To gain substantial health benefits a minimum of 150 min of moderate or vigorous intense aerobic physical activity and muscle strengthening activities per week are needed. Additionally, inactivity should be recognised as health hazard and prolonged episodes of sitting should be avoided. Read More

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http://dx.doi.org/10.1007/s00508-019-1457-xDOI Listing

[Smoking, alcohol and diabetes (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

5. Medizinische Abteilung für Endokrinologie, Rheumatologie und Akutgeriatrie, Wilhelminenspital der Stadt Wien, Wien, Österreich.

Smoking and second-hand smoke strongly increase incidence of diabetes and probability for its complications. Smoking cessation can lead to weight gain and increased diabetes risk; however, it decreases cardiovascular and total mortality. A basal diagnostics (Fagerström Test, exhaled CO) is the basis for successful smoking cessation. Read More

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http://link.springer.com/10.1007/s00508-019-1455-z
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http://dx.doi.org/10.1007/s00508-019-1455-zDOI Listing
April 2019
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[Other specific types of diabetes and exocrine pancreatic insufficiency (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Klinische Abteilung für Endokrinologie und Stoffwechsel, Universitätsklinik für Innere Medizin III, Medizinische Universität Wien, Wien, Österreich.

The heterogenous catagory "specific types of diabetes due to other causes" encompasses disturbances in glucose metabolism due to other endocrine disorders such as acromegaly or hypercortisolism, drug-induced diabetes (e. g. antipsychotic medications, glucocorticoids, immunosuppressive agents, highly active antiretroviral therapy (HAART)), genetic forms of diabetes (e. Read More

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http://dx.doi.org/10.1007/s00508-019-1454-0DOI Listing

[Clinical practice recommendations for diabetes in pregnancy (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Interne Abteilung, Landeskrankenhaus Hochzirl - Natters, Hochzirl, Österreich.

In 1989 the St. Vincent Declaration aimed to achieve comparable pregnancy outcomes in diabetic and non-diabetic women. However, currently women with pre-gestational diabetes still feature a higher risk of perinatal morbidity and even increased mortality. Read More

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http://dx.doi.org/10.1007/s00508-019-1456-yDOI Listing

[Hospital diabetes management (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Klinische Abteilung für Endokrinologie und Diabetologie, Universitätsklinik für Innere Medizin, Medizinische Universität Graz, Auenbruggerplatz 15, 8036, Graz, Österreich.

This position statement presents the recommendations of the Austrian Diabetes Association for diabetes management of adult patients during inpatient stay. It is based on the current evidence with respect to blood glucose targets, insulin therapy and treatment with oral antidiabetic drugs during inpatient hospitalization. Additionally, special circumstances such as intravenous insulin therapy, concomitant therapy with glucocorticoids and use of diabetes technology during hospitalization are discussed. Read More

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http://link.springer.com/10.1007/s00508-019-1447-z
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http://dx.doi.org/10.1007/s00508-019-1447-zDOI Listing
April 2019
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[Diabetes education and counselling in adult patients with diabetes (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

1. Medizinische Abteilung mit Diabetologie, Endokrinologie und Nephrologie, Krankenanstalt Rudolfstiftung, Wien, Österreich.

Diabetes education and self-management play a critical role in diabetes care. Patient empowerment aims to actively influence the course of the disease by self-monitoring and subsequent treatment modification as well as the ability of patients to integrate diabetes into their daily life and to appropriately adapt it to their life style situation. Diabetes education has to be made accessible for all persons with the disease. Read More

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http://dx.doi.org/10.1007/s00508-019-1449-xDOI Listing

[Treatment of acute diabetic metabolic crises in adults (Update 2019) : Hyperglycemic hyperosmolar state and ketoacidotic metabolic disorders].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Klinische Abteilung für Endokrinologie und Stoffwechsel, Universitätsklinik für Innere Medizin III, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.

Diabetic ketoacidosis (DKA) and the hyperglycemic hyperosmolar state (HHS) represent potentially life-threatening situations in adults. Therefore, rapid comprehensive diagnostic and therapeutic measures with close monitoring of vital and laboratory parameters are required. The treatment of DKA and HHS is essentially the same and replacement of the mostly substantial fluid deficit with several liters of a physiological crystalloid solution is the first and most important step. Read More

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http://link.springer.com/10.1007/s00508-018-1423-z
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http://dx.doi.org/10.1007/s00508-018-1423-zDOI Listing
April 2019
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[Diagnosis, treatment and monitoring of diabetic eye disease (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Universitäts-Augenklinik, Medizinische Universität Graz, Graz, Österreich.

Diabetes mellitus can cause diabetic retinopathy, diabetic macular edema, optic neuropathy, cataract or dysfunction of the eye muscles. The incidence of these defects correlates with disease duration and quality of metabolic control. Recommendations of the Austrian Diabetes Association for diagnosis, therapeutic procedures and requirements for adequate follow-up depending on stage of diabetic eye disease are summarized. Read More

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http://dx.doi.org/10.1007/s00508-019-1445-1DOI Listing

[Migration and diabetes (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

5. Medizinische Abteilung mit Endokrinologie, Rheumatologie und Akutgeriatrie, Wilhelminenspital der Stadt Wien, Montlearstraße 37, 1160, Wien, Österreich.

The article deals with the demographic data of migration in Austria and with therapeutic advice concerning drug therapy and diabetes education for patients with migration background. In this context sociocultural specifics are discussed. These suggestions are seen complementary to the general treatment guidelines of the Austrian Diabetes Association. Read More

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http://link.springer.com/10.1007/s00508-019-1446-0
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http://dx.doi.org/10.1007/s00508-019-1446-0DOI Listing
April 2019
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[Lipids-Diagnosis and therapy in diabetes mellitus (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Abteilung für Innere Medizin und Intensivmedizin, Krankenhaus der Barmherzigen Brüder Linz, Linz, Österreich.

Hyper- and dyslipidemia contribute to cardiovascular morbidity and mortality in diabetic patients. Pharmacological therapy to lower LDL cholesterol has convincingly shown to reduce cardiovascular risk in diabetic patients. The present article represents the recommendations of the Austrian Diabetes Association for the use of lipid-lowering drugs in diabetic patients according to current scientific evidence. Read More

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http://link.springer.com/10.1007/s00508-019-1444-2
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http://dx.doi.org/10.1007/s00508-019-1444-2DOI Listing
April 2019
2 Reads