40,694 results match your criteria Mediterranean Fever Familial


Atypical type of familial Mediterranean fever: An underdiagnosed cause of chronic aseptic meningitis.

Neurol Clin Neurosci 2018 Nov 24;6(6):191-193. Epub 2018 Sep 24.

Department of Neurology Shin-yurigaoka General Hospital Kanagawa Japan.

We report an atypical case of familial Mediterranean fever (FMF) concomitant with chronic aseptic meningitis. The patient experienced fever, abdominal and back pain because of serositis, and headache because of aseptic meningitis for 4 weeks. Blood examinations revealed increased white blood cells and serum amyloid A level. Read More

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November 2018
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First Balanced Cross Section Across the Taurides Fold-Thrust Belt: Geological Constraints on the Subduction History of the Antalya Slab in Southern Anatolia.

Tectonics 2018 Oct 18;37(10):3738-3759. Epub 2018 Oct 18.

Department of Earth Sciences Utrecht University, Vening Meineszgebouw A Utrecht Netherlands.

Eastern Mediterranean subduction accommodated Africa-Eurasia convergence since Mesozoic time and produced multiple subducted slab fragments in the mantle below Anatolia. These included the north dipping Cyprus and ENE-dipping Antalya slabs, which are currently separated by an upper mantle slab gap. Segmentation of these slabs, and associated mantle flow, may have contributed to <8 Ma uplift of the Central Anatolian Plateau. Read More

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October 2018

The archaeological ensemble from Campoverde (Agro Pontino, central Italy): new constraints on the Last Interglacial sea level markers.

Sci Rep 2018 Dec 13;8(1):17837. Epub 2018 Dec 13.

Università di Roma "Sapienza", Dipartimento di Scienze della Terra, P.le Aldo Moro 5, 00185, Rome, Italy.

We present a combined geomorphological and biochronological study aimed at providing age constraints to the deposits forming a wide paleo-surface in the coastal area of the Tyrrhenian Sea, south of Anzio promontory (central Italy). We review the faunal assemblage recovered in Campoverde, evidencing the occurrence of the modern fallow deer subspecies Dama dama dama, which in peninsular Italy is not present before MIS 5e, providing a post-quem terminus of 125 ka for the deposit hosting the fossil remains. The geomorphological reconstruction shows that Campoverde is located within the highest of three paleosurfaces progressively declining towards the present coast, at average elevations of 36, 26 and 15 m a. Read More

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December 2018

A priori-defined Mediterranean-like dietary pattern predicts cardiovascular events better in north Europe than in Mediterranean countries.

Int J Cardiol 2018 Nov 29. Epub 2018 Nov 29.

Centro Cardiologico Monzino, IRCCS, Milan, Italy; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy.

Background: The Mediterranean Diet (MD) is a model of healthy eating contributing to a favorable health status, but its clinical usefulness is still debated. The aim of this study was to relate the adherence to MD with the incidence of cardio/cerebro-vascular events (VEs) in north and south European participants of the IMPROVE study.

Methods: IMPROVE is an observational, longitudinal, prospective cohort study involving 3703 individuals from five European countries (Finland, Sweden, Netherlands, France and Italy). Read More

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November 2018

Nutrition and Cardiovascular Health.

Int J Mol Sci 2018 Dec 11;19(12). Epub 2018 Dec 11.

Department of Internal Medicine, Hospital Clinic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel, 170, 08036 Barcelona, Spain.

Cardiovascular disease (CVD) is the leading cause of death in Western countries, representing almost 30% of all deaths worldwide. Evidence shows the effectiveness of healthy dietary patterns and lifestyles for the prevention of CVD. Furthermore, the rising incidence of CVD over the last 25 years has become a public health priority, especially the prevention of CVD (or cardiovascular events) through lifestyle interventions. Read More

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December 2018

Oleuropein Induces AMPK-Dependent Autophagy in NAFLD Mice, Regardless of the Gender.

Int J Mol Sci 2018 Dec 8;19(12). Epub 2018 Dec 8.

F. Balsano Foundation, Via Giovanni Battista Martini 6, 00198 Rome, Italy.

Oleuropein (Ole) is one of the most plentiful phenolic compounds with antioxidant, anti-inflammatory, anti-atherogenic, hypoglycemic and hypolipidemic effects. The aim of our study was to establish whether the positive Ole-related effects on liver steatosis could be associated with autophagy. Female and male C57BL/6J mice were fed normal diet (ND) or high-fat diet (HFD) for eight weeks, and Ole was added or not for the following eight weeks. Read More

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December 2018
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Liver Fat Content and Body Fat Distribution in Youths with Excess Adiposity.

J Clin Med 2018 Dec 7;7(12). Epub 2018 Dec 7.

Centro de Estudios Para la Medición de la Actividad Física CEMA, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá 111221, Colombia.

This study had two main objectives: To examine the association between body fat distribution and non-alcoholic fatty liver disease (NAFLD) and liver fat content, and to determine whether the relationship between NAFLD and regional body fat distribution, with respect to liver fat content in youths with excess adiposity, is independent of cardiorespiratory fitness (CRF) and a healthy diet. Liver fat content (controlled attenuation parameter (CAP)), body fat distribution (body mass index (BMI) -score, waist circumference, waist-to-height ratio, fat mass/height, body fat percentage, total fat mass, android-to-gynoid fat mass ratio, visceral adipose tissue (VAT), and lean mass index, determined by dual-energy X-ray absorptiometry (DXA)), CRF (20-m shuttle-run test), and healthy diet (adherence to the Mediterranean diet by KIDMED questionnaire) were measured in 126 adolescents (66% girls) aged between 11 and 17 years. Participants were assigned to two groups according to the presence or absence of hepatic steatosis (CAP values ≥225 dB/m or <225 dB/m of liver fat, respectively). Read More

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December 2018

Parietaria Allergy: An Intriguing Challenge for the Allergist.

Medicina (Kaunas) 2018 Dec 7;54(6). Epub 2018 Dec 7.

Department of Otorhinolaryngology, Sapienza University, 00100 Rome, Italy.

pollen is the most important cause of pollen allergies in the Mediterranean area, as is widespread in this region. Many issues are associated with allergy, including the duration of the pollen season (many doctors in fact believe that it lasts throughout the year), pollen load (which seems to be increasing over time), the impact of age (on IgE production and symptom severity), inflammatory changes (after pollen exposure), and the choice of allergen immunotherapy (AIT). In addition, molecular diagnostics allows for the defining of a correct diagnosis, differentiating between mere sensitization and true allergy. Read More

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December 2018

Emerging Mosquito-Borne Threats and the Response from European and Eastern Mediterranean Countries.

Int J Environ Res Public Health 2018 Dec 7;15(12). Epub 2018 Dec 7.

UMR BIPAR, Animal Health Laboratory, ANSES, INRA, Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, 94700 Maisons-Alfort, France.

Mosquito-borne viruses are the cause of some of the greatest burdens to human health worldwide, particularly in tropical regions where both human populations and mosquito numbers are abundant. Due to a combination of anthropogenic change, including the effects on global climate and wildlife migration there is strong evidence that temperate regions are undergoing repeated introduction of mosquito-borne viruses and the re-emergence of viruses that previously were not detected by surveillance. In Europe, the repeated introductions of West Nile and Usutu viruses have been associated with bird migration from Africa, whereas the autochthonous transmission of chikungunya and dengue viruses has been driven by a combination of invasive mosquitoes and rapid transcontinental travel by infected humans. Read More

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December 2018

A holistic view on implementing hospital autonomy reforms in developing countries: a systematic review.

Health Policy Plan 2018 Dec 13. Epub 2018 Dec 13.

World Health Organization, Regional Office for the Eastern Mediterranean, Monazamet El Seha El Alamia Street, Extension of Abdel Razak El Sanhouri Street, P.O. Box 7608, Nasr City 11371, Cairo, Egypt.

The excessive use of resources, inefficiency and poor service quality in public hospitals has led developing countries to create reforms in public hospital governance, including autonomization. Hospital autonomy refers to the delegation of administrative rights to the hospital management team. The purpose of the present research is to review different aspects of hospital autonomy reforms in developing countries, such as incentives, preparations, obstacles and facilitators to change prior to implementation, impacts on achieving Universal Health Coverage (UHC) goals, challenges, outcomes and implications for implementation. Read More

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December 2018

Local topographic and edaphic factors largely predict shrub encroachment in Mediterranean drylands.

Sci Total Environ 2018 Dec 1;657:310-318. Epub 2018 Dec 1.

Centre for Ecology, Evolution and Environmental Changes, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, C2, Piso 5, 1749-016 Lisboa, Portugal. Electronic address:

Shrub encroachment influences several ecosystem services in drylands worldwide. Yet, commonly used strategies to reduce encroachment show a low medium-term success, calling for a better understanding of its causes. Previous works identified multiple drivers responsible for this phenomenon, including anthropogenic and environmental causes. Read More

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December 2018

Discriminating growth stages of an endangered Mediterranean relict plant (Ammopiptanthus mongolicus) in the arid Northwest China using hyperspectral measurements.

Sci Total Environ 2018 Dec 6;657:270-278. Epub 2018 Dec 6.

School of Environment and Energy, Peking University Shenzhen Graduate School, Shenzhen 518055, China. Electronic address:

Ammopiptanthus mongolicus, the only drought-resistant, leguminous, evergreen shrub in the desert region of China, is endangered due to climate change and its growth stages urgently need to be non-destructively detected. Although many spectral indexes have been proposed for characterizing vegetation, the relationships are often inconsistent, making it challenging to characterize the status of vegetation across all growth stages. This study investigated the Spectral Features of the endangered desert plant A. Read More

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December 2018

Germination rates of four Chilean forest trees seeds: , , and .

F1000Res 2018 10;7:1446. Epub 2018 Sep 10.

Universidad de Chile, Santiago, Chile.

Data on the germination rates of four tree species, natively founded in the Chilean Mediterranean-climate zone, were determined by germination in crop chambers. The obtained data were used to interpolate or extrapolate the time taken for 50% of seeds to germinate in each case. These results are useful for regional native forest research and, in a broad sense, for its use in models to study germination dynamics in Mediterranean-climate zones. Read More

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September 2018

Different Responses of Various Chlorophyll Meters to Increasing Nitrogen Supply in Sweet Pepper.

Front Plant Sci 2018 27;9:1752. Epub 2018 Nov 27.

CIAIMBITAL Research Centre for Mediterranean Intensive Agrosystems and Agrifood Biotechnology, Department of Agronomy, University of Almería, Almeria, Spain.

Intensive vegetable production is commonly associated with excessive nitrogen (N) fertilization and associated environmental problems. Monitoring of crop N status can enhance crop N management. Chlorophyll meters (CMs) could be used to monitor crop N status because leaf chlorophyll (chl) content is strongly related to crop N status. Read More

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November 2018

Fatty Acids and Phenolic Profiles of Extravirgin Olive Oils from Selected Italian Cultivars Introduced in Southwestern Province of Pakistan.

J Oleo Sci 2018 Dec 12. Epub 2018 Dec 12.

Institute of Biochemistry, University of Balochistan.

Mediterranean olive trees have been cultivated in Pakistan for decades to promote olive cultivation and use of olive oil. The qualitative characteristics of seven mono and one multi-varietal extra virgin olive oils (EVOOs) extracted from Italian cultivars grown in different areas of Balochistan a southwestern province of Pakistan were evaluated. Present study aims to assess the impact of bioclimatological change on biochemical profile of exotic cultivars. Read More

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December 2018

MEditerranean FeVer ( MEFV ) gene mutations in glomerulonephritides: a clinicopathological study

Turk J Med Sci 2018 12 12;48(6):1182-1191. Epub 2018 Dec 12.

Department of Nephrology, Faculty of Medicine, Ankara University, Ankara, Turkey

Background/aim: The aim of this study is to determine the ME diterranean F e V er ( MEFV ) gene mutation carrier rate in patients with glomerulonephritis and to investigate the association between disease features and MEFV variants.

Materials And Methods: Medical records regarding clinical, laboratory, histopathological, and prognostic features of 200 adult patients with biopsy-proven glomerulonephritis were evaluated retrospectively. Exons 2 and 10 of the MEFV gene of each patient were sequenced by next-generation sequencing. Read More

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December 2018

A food-based score and incidence of overweight/obesity: The Dietary Obesity-Prevention Score (DOS).

Clin Nutr 2018 Nov 23. Epub 2018 Nov 23.

Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain; Biomedical Research Center Network on Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III (ISCIII), Madrid, Spain; Navarra's Health Research Institute (IDISNA), Pamplona, Spain. Electronic address:

Background & Aims: Given the enormous health, economic and societal consequences of the obesity pandemic, identifying effective primary prevention strategies represents a global priority. The aim of this study was to provide evidence on the association between adherence to a food-based score reflecting a set of targeted, well-informed, simple dietary recommendations and the incidence of overweight/obesity.

Methods: A total of 11,349 initially free of overweight/obesity young adults (mean [SD] age: 34. Read More

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November 2018
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[A Rickettsia case caused by Rickettsia conorii].

Mikrobiyol Bul 2018 Oct;52(4):431-438

Ministry of Health, General Directorate of Public Health, Microbiology Reference Laboratory, Ankara, Turkey.

Rickettsia species are gram-negative intracellular, small pleomorphic coccobacilli in the Rickettsiaceae family. This genus is serologically and genotypically divided into four groups as spotted fever group, typhus group, Rickettsia belli and Rickettsia canadensis. Rickettsia conorii (R. Read More

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October 2018

Regional paleoclimates and local consequences: Integrating GIS analysis of diachronic settlement patterns and process-based agroecosystem modeling of potential agricultural productivity in Provence (France).

PLoS One 2018 12;13(12):e0207622. Epub 2018 Dec 12.

Schools of Sustainability and Human Evolution and Social Change, Arizona State University, Tempe, Arizona, United States of America.

Holocene climate variability in the Mediterranean Basin is often cited as a potential driver of societal change, but the mechanisms of this putative influence are generally little explored. In this paper we integrate two tools-agro-ecosystem modeling of potential agricultural yields and spatial analysis of archaeological settlement pattern data-in order to examine the human consequences of past climatic changes. Focusing on a case study in Provence (France), we adapt an agro-ecosystem model to the modeling of potential agricultural productivity during the Holocene. Read More

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December 2018
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Mediterranean herb extracts inhibit microbial growth of representative oral microorganisms and biofilm formation of Streptococcus mutans.

PLoS One 2018 12;13(12):e0207574. Epub 2018 Dec 12.

Department of Operative Dentistry and Periodontology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

In light of the growing antibiotic resistance, the usage of plant-derived antimicrobial agents could serve as an effective alternative treatment against oral infections. The aim of this study was to investigate the antimicrobial and antibiofilm activity of Mediterranean herb extracts against representative oral microorganisms. The extraction procedures and the analysis of the obtained extracts were performed under established experimental conditions. Read More

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December 2018

Essential oils and functional herbs for healthy aging.

Neural Regen Res 2019 Mar;14(3):441-445

School of Pharmacy and Applied Science, La Trobe Institute for Molecular Sciences, La Trobe University, Bendigo, Australia.

As total life expectancy increases, the prevalence of age-related diseases such as diabetes and Alzheimer's disease is also increasing. Many hypotheses about Alzheimer's disease have been developed, including cholinergic neuron damage, oxidative stress, and inflammation. Acetylcholine is a major neurotransmitter in the brain and cholinergic deficits leads to cognitive dysfunction and decline. Read More

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March 2019
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Th1/Th2 Dichotomy in Obese Women with Gestational Diabetes and Their Macrosomic Babies.

J Diabetes Res 2018 14;2018:8474617. Epub 2018 Nov 14.

Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, 5005 Dakar-Fann, Senegal.

The aim of the study was to assess T cell differentiation and the modulation of inflammatory cytokines in obese and gestational diabetes mellitus (GDM) women and their macrosomic newborns. Hence, immediately after delivery, blood samples were collected through the mother's arm vein and the umbilical cordon vein. Biochemical parameters measured were HbA1C, glucose, insulin, triglyceride (TG), total cholesterol (Tchol), HDL cholesterol (HDLchol), and LDL cholesterol (LDLchol). Read More

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November 2018
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Survey on broiler -slaughter mortality in a commercial abattoir of central Italy.

Ital J Food Saf 2018 Sep 6;7(3):5878. Epub 2018 Nov 6.

School of Biosciences and Veterinary Medicine, University of Camerino, Matelica.

The -slaughter mortality was investigated on broilers, in the Mediterranean climate condition, considering the most significant risk factors as the journey length, waiting time, season and the space allowance in cages. At first, the -slaughter mortality was studied considering the totality of birds and then by examining in detail three broiler categories: large, medium and small size. The average dead on arrival (DOA) recorded on the totality of birds throughout the year was 0. Read More

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September 2018

Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis.

Oxid Med Cell Longev 2018 13;2018:6053492. Epub 2018 Nov 13.

Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brazil.

The Mediterranean diet, rich in olive oil, is beneficial, reducing the risk of cardiovascular diseases and cancer. Olive oil is mostly composed of the monounsaturated fatty acid omega-9. We showed omega-9 protects septic mice modulating lipid metabolism. Read More

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November 2018

Geography and Environment Shape Landscape Genetics of Mediterranean Alpine Species Poiret. (Caryophyllaceae).

Front Plant Sci 2018 27;9:1698. Epub 2018 Nov 27.

Área de Biodiversidad y Conservación, Escuela Superior de Ciencias Experimentales y Tecnología (ESCET), Universidad Rey Juan Carlos, Madrid, Spain.

The study of the drivers that shape spatial genetic structure across heterogeneous landscapes is one of the main approaches used to understand population dynamics and responses in changing environments. While the Isolation-by-Distance model (IBD) assumes that genetic differentiation increases among populations with geographical distance, the Isolation-by-Resistance model (IBR) also considers geographical barriers and other landscape features that impede gene flow. On the other hand, the Isolation-by-Environment model (IBE) explains genetic differentiation through environmental differences between populations. Read More

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November 2018

Somatotropic Axis Regulation Unravels the Differential Effects of Nutritional and Environmental Factors in Growth Performance of Marine Farmed Fishes.

Front Endocrinol (Lausanne) 2018 27;9:687. Epub 2018 Nov 27.

Nutrigenomics and Fish Growth Endocrinology, Institute of Aquaculture Torre de la Sal (IATS-CSIC), Castellón, Spain.

The Gh/Prl/Sl family has evolved differentially through evolution, resulting in varying relationships between the somatotropic axis and growth rates within and across fish species. This is due to a wide range of endogenous and exogenous factors that make this association variable throughout season and life cycle, and the present minireview aims to better define the nutritional and environmental regulation of the endocrine growth cascade over precisely defined groups of fishes, focusing on Mediterranean farmed fishes. As a result, circulating Gh and Igf-i are revitalized as reliable growth markers, with a close association with growth rates of gilthead sea bream juveniles with deficiency signs in both macro- or micro-nutrients. Read More

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November 2018

Body, Brain, Life for Cognitive Decline (BBL-CD): protocol for a multidomain dementia risk reduction randomized controlled trial for subjective cognitive decline and mild cognitive impairment.

Clin Interv Aging 2018 21;13:2397-2406. Epub 2018 Nov 21.

Centre for Research on Ageing, Health and Wellbeing, Research School of Population Health, The Australian National University, Canberra, ACT, Australia,

Background: With no cure for dementia and the number of people living with the condition predicted to rapidly rise, there is an urgent need for dementia risk reduction and prevention interventions. Modifiable lifestyle risk factors have been identified as playing a major role in the development of dementia; hence, interventions addressing these risk factors represent a significant opportunity to reduce the number of people developing dementia. Relatively few interventions have been trialed in older participants with cognitive decline (secondary prevention). Read More

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November 2018
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Linking organochlorine contaminants with demographic parameters in free-ranging common bottlenose dolphins from the northern Adriatic Sea.

Sci Total Environ 2018 Dec 4;657:200-212. Epub 2018 Dec 4.

Morigenos - Slovenian Marine Mammal Society, Kidričevo nabrežje 4, 6330 Piran, Slovenia.

Marine top predators, including marine mammals, are known to bio-accumulate persistent pollutants such as polychlorinated biphenyls (PCBs), a serious conservation concern for these species. Although PCBs declined in European seas since the 1970s-1980s ban, considerable levels still persist in European and Mediterranean waters. In cetaceans, stranded animals are a valuable source of samples for pollutant studies, but may introduce both known and unknown biases. Read More

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December 2018
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Rickettsioses: Cutaneous findings frequently lead to diagnosis - a review.

J Dtsch Dermatol Ges 2018 Dec;16(12):1459-1476

While epidemic typhus caused by Rickettsia prowazekii posed a significant threat in Europe before and throughout World War II due to its high mortality, the condition fortunately no longer plays a significant role. Nevertheless, rickettsioses, such as African tick bite fever, have been increasingly diagnosed in travelers returning from sub-Saharan Africa. Caused by Rickettsia africae, African tick bite fever presents with characteristic cutaneous findings such as eschar (tache noir) and a rash. Read More

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December 2018

Metabolic and physiological responses of Mediterranean high-mountain and Alpine plants to combined abiotic stresses.

Physiol Plant 2018 Dec 10. Epub 2018 Dec 10.

Departamento de Farmacología, Farmacognosia y Botánica, Unidad de Fisiología Vegetal. Facultad de Farmacia. Universidad Complutense de Madrid, Spain.

High-mountain areas provide excellent opportunities to study the effects of combined abiotic stresses on plant physiology given their variety of steep ecological gradients, low anthropogenic disturbance, and remarkable levels of taxonomic diversity. Efficient photoprotective and antioxidant scavenging mechanisms are vital for survival in high-mountain plants, having its altitudinal and seasonal variations determined by environmental or ontogenetic factors such as the decrease in mean temperatures and water availability. A number of stress indicators have been described in order to rapidly assess plant fitness in high-mountain environments. Read More

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December 2018

Atherothrombotic risk stratification after acute myocardial infarction: the TIMI Risk Score for Secondary Prevention (TRS-2P) in the light of the FAST-MI registries.

Clin Cardiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Cardiology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou (HEGP), Paris, France.

Background: Guidelines recommend using risk stratification tools in acute myocardial infarction (AMI) to assist decision making. The TIMI Risk Score for Secondary Prevention (TRS-2P) has been recently developed to characterize long term risk in patients with MI.

Hypothesis: We aimed to assess the TRS-2P in the FAST-MI registries. Read More

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December 2018

The link between selfing and greater dispersibility in a heterocarpic Asteraceae.

Am J Bot 2018 Dec 11. Epub 2018 Dec 11.

Departamento de Biología Vegetal y Ecología, Universidad de Sevilla, Apdo. 1095, 41080, Sevilla, Spain.

Premise Of The Study: Although an evolutionary link between breeding system and dispersibility has been proposed, to date empirical data and theoretical models of plants show contrasting trends.

Methods: We tested two competing hypotheses for the association between breeding systems and dispersibility in the heterocarpic Hypochaeris salzmanniana (Asteraceae) by using both an experimental approach and surveys over 2 years of five natural populations along an environmental cline with a gradient of pollinator availability.

Key Results: Hypochaeris salzmanniana produced two types of fruits, beaked (BF) and nonbeaked (NBF), which differ in their dispersal ability. Read More

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December 2018

Effect of interleukin-1 antagonists on the quality of life in familial Mediterranean fever patients.

Clin Rheumatol 2018 Dec 10. Epub 2018 Dec 10.

Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Gazi University, 06100, Ankara, Turkey.

Background: Familial Mediterranean fever (FMF) patients suffer from chronic complications of disease such as AA amyloidosis, chronic arthritis, and spondylitis. Reduced quality of life (QoL) is a feature of chronic diseases but it is also impaired in patients with FMF. Despite the regular use of colchicine at a maximal dose, about 10% of patients do not respond well or resistant to colchicine (crFMF). Read More

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December 2018

Tofacitinib for familial Mediterranean fever: a new alternative therapy?

Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.

Department of Internal Medicine, Grupo de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional, Fundación Valle Del Lili and Universidad Icesi, Cali, Colombia.

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December 2018

Draft Genome Sequence of Shewanella algidipiscicola H1, a Highly Chromate-Resistant Strain Isolated from Mediterranean Marine Sediments.

Microbiol Resour Announc 2018 Aug 30;7(8). Epub 2018 Aug 30.

Aix Marseille Université, CNRS, BIP UMR 7281, Marseille, France.

The ability of different Shewanella spp. to convert heavy metals and toxic substances into less toxic products by using them as electron acceptors has led to their use in environmental clean-up strategies. We present here the draft genome sequence of Shewanella algidipiscicola H1, a strain resistant to high concentrations of chromates. Read More

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Draft Genome Sequence of Plant Growth-Promoting Bacillus altitudinis Strain PAE4.

Microbiol Resour Announc 2018 Oct 4;7(13). Epub 2018 Oct 4.

CNRS, Université de Lyon, Université Claude Bernard Lyon 1, INRA, VetAgro Sup, UMR 5557 Ecologie Microbienne, Villeurbanne, France.

We report here the draft genome of Bacillus altitudinis strain PAE4, a thermophilic plant growth-promoting rhizobacterium isolated from the coastal ridge of the Mediterranean Sea in Egypt. Besides heat shock protein genes, several genes encoding phytobeneficial properties were identified. Read More

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October 2018

A DNA barcode-assisted annotated checklist of the spider (Arachnida, Araneae) communities associated to white oak woodlands in Spanish National Parks.

Biodivers Data J 2018 29(6):e29443. Epub 2018 Nov 29.

Department of Evolutionary Biology, Ecology and Environmental Sciences & Biodiversity Research Institute (IRBio), Universitat de Barcelona, Av. Diagonal 643, E-08028, Barcelona, Spain Department of Evolutionary Biology, Ecology and Environmental Sciences & Biodiversity Research Institute (IRBio), Universitat de Barcelona, Av. Diagonal 643, E-08028 Barcelona Spain.

Background: A large scale semi-quantitative biodiversity assessment was conducted in white oak woodlands in areas included in the Spanish Network of National Parks, as part of a project aimed at revealing biogeographic patterns and identify biodiversity drivers. The semi-quantitative COBRA sampling protocol was conducted in sixteen 1-ha plots across six national parks using a nested design. All adult specimens were identified to species level based on morphology. Read More

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November 2018
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The easternmost discovery of the Mediterranean weevil (Coleoptera, Curculionidae, Entiminae): Is a further invasion possible?

Zookeys 2018 28(799):89-93. Epub 2018 Nov 28.

University of Oslo, Natural History Museum, Department of Zoology, P.O. Box 1172, Blindern, NO-0318 Oslo, Norway A.N. Severtsov Institute of Ecology and Evolution Moscow Russia.

(Desbrochers des Loges, 1875) is a Mediterranean weevil species that has become remarkably well known as a result of a series of recent introductions across Western and Central Europe. This species has recently reached Asia Minor and the Crimean Peninsula, as confirmed by several new records. The vectors of invasion in Crimea and possible further expansion are suggested. Read More

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November 2018

Long-term risk of cardiovascular events after detecting silent coronary atheromatosis using computed tomography.

Coron Artery Dis 2018 Dec 10. Epub 2018 Dec 10.

Cardiology Service, Hospital Sanitas Cima.

Background: Coronary calcium score (CCS) and coronary computed tomography angiography (CTA) assessments using multidetector computed tomography are invaluable for atheromatosis screening. We studied their usefulness in cardiovascular risk assessments, and compared evaluations using the Systematic COronary Risk Evaluation (SCORE) algorithm with those from CTA and CSS assessments in terms of their ability to predict cardiovascular events in Mediterranean patients.

Patients And Methods: Two hundred and sixty-six asymptomatic patients whose mean age was 55. Read More

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December 2018

Diagnosis and treatment of multi-species fish mortality attributed to Enteromyxum leei while in quarantine at a US aquarium.

Dis Aquat Organ 2018 Dec;132(1):37-48

Adventure Aquarium, Camden, New Jersey 08103, USA.

Enteromyxum leei is an enteric myxozoan parasite of fish. This myxozoan has low host specificity and is the causative agent of myxozoan emaciation disease, known for heavy mortalities and significant financial losses within Mediterranean, Red Sea, and Asian aquaculture industries. The disease has rarely been documented within public aquaria and, to our knowledge, has never been confirmed within the USA. Read More

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December 2018

Physiological and biochemical attributes of Mentha spicata when subjected to saline conditions and cation foliar application.

J Plant Physiol 2018 Nov 3;232:27-38. Epub 2018 Nov 3.

Department of Agricultural Sciences, Biotechnology and Food Science, Cyprus University of Technology, Lemesos, 3603, Cyprus. Electronic address:

Marginal water, including saline water, has been proposed as an alternative source of irrigation water for partially covering plant water requirements due to scarcity of adequate water supply in hot arid and semi-arid areas, such as those usually found in the Mediterranean basin. In the present study, spearmint plants (Mentha spicata L.) were grown in a deep flow hydroponic system under saline conditions, namely 0, 25, 50, and 100 mM NaCl. Read More

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November 2018

An assessment framework for climate-proof nature-based solutions.

Sci Total Environ 2018 Nov 24;656:691-700. Epub 2018 Nov 24.

Euro-Mediterranean Center on Climate Change, Ca' Foscari University of Venice, Edificio Porta dell'Innovazione - Piano 2, Via della Libertà, 12, 30175, Marghera, Venice, VE, Italy; Fondazione Eni Enrico Mattei, Isola di San Giorgio Maggiore 8, 30124 Venice, VE, Italy.

Raising interest in 'nature-based solutions' (NBS) has inspired attempts to organise their principles and qualities within comprehensive and internally consistent evaluation frameworks, so as to demonstrate the superior performance of 'working with nature'. However, the proposed frameworks stop short of taking into account the changing conditions in which NBS are set to operate. Climate change, in particular, can alter ecosystems and their services, and may undermine the performance of green solutions that rely on them. Read More

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November 2018

Tetrodotoxin levels of three pufferfish species (Lagocephalus sp.) caught in the North-Eastern Mediterranean sea.

Chemosphere 2018 Dec 3;219:95-99. Epub 2018 Dec 3.

Faculty of Fisheries, Çukurova University, Adana, Turkey.

Tetrodotoxin (TTX) levels in Lagocephalus sceleratus (Silverstripe blaasop), Lagocephalus spadiceus (Half-smooth golden pufferfish) and Lagocephalus suezensis (Suez puffer) caught in Mersin Bay in the Northeastern Mediterranean Sea were analysed using Q-TOF LC/MS. Pufferfish were caught using trawl fishing, longlining and fishing line from December 2015 to October 2016. The TTX changes in the gonads, livers, intestines, skins and muscle tissues were evaluated according to sex and season. Read More

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December 2018

Persisting Worldwide Seabird-Fishery Competition Despite Seabird Community Decline.

Curr Biol 2018 Nov 26. Epub 2018 Nov 26.

Sea Around Us, Institute for the Oceans and Fisheries, University of British Columbia, 2202 Main Mall, Vancouver, BC V6T 1Z4, Canada.

Fisheries transform marine ecosystems and compete with predators [1], but temporal trends in seabird-fishery competition had never been assessed on a worldwide scale. Using catch reconstructions [2] for all fisheries targeting taxa that are also seabird prey, we demonstrated that average annual fishery catch increased from 59 to 65 million metric tons between 1970-1989 and 1990-2010. For the same periods, we estimated that global annual seabird food consumption decreased from 70 to 57 million metric tons. Read More

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November 2018

Recovering microbial genomes from metagenomes in hypersaline environments: The Good, the Bad and the Ugly.

Syst Appl Microbiol 2018 Nov 15. Epub 2018 Nov 15.

Department of Physiology, Genetics and Microbiology, University of Alicante, Alicante, Spain; Multidisciplinary Institute of Environmental Studies Ramon Margalef, University of Alicante, Alicante, Spain. Electronic address:

Current metagenomic tools allow the recovery of microbial genomes directly from the environment. This can be accomplished by binning metagenomic contigs according to their coverage and tetranucleotide frequency, followed by an estimation of the bin quality. The public availability of bioinformatics tools, together with the decreasing cost of next generation sequencing, are democratizing this powerful approach that is spreading from specialized research groups to the general public. Read More

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November 2018

Oceanographic characteristics of the Adriatic Sea - Support to secondary HAOP spread through natural dispersal.

Mar Pollut Bull 2018 Dec 5. Epub 2018 Dec 5.

Ruđer Bošković Institute, Center for Marine Research, G. Paliage 5, 52210 Rovinj, Croatia. Electronic address:

Vessels, specifically ballast water and hull fouling, are a major vector for the introduction of non-indigenous species (NIS) in European seas. The Mediterranean is one of the world's marine regions where their invasion is heaviest. The shallow Adriatic basin is a highly sensitive area that is already experiencing its consequences. Read More

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December 2018

Interaction between Mediterranean diet and statins on mortality risk in patients with cardiovascular disease: Findings from the Moli-sani Study.

Int J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell'Elettronica, 86077 Pozzilli, IS, Italy; Department of Medicine and Surgery, Research Center in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, 21100 Varese, Italy.

Background: Statins are prescribed for patients with cardiovascular disease (CVD), along with the recommendation of adopting healthy diets. We evaluated the independent and the combined effect of statins and Mediterranean diet (MD) towards mortality risk in patients with previous CVD by using real-life data from a population-based prospective cohort.

Methods: Longitudinal analysis on 1180 subjects (mean age 67. Read More

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November 2018

AA amyloidosis associated with morbid obesity (clinical case).

Reumatol Clin 2018 Dec 4. Epub 2018 Dec 4.

Pathological Anatomy Service, Cabueñes Hospital, Gijón, Asturias, Spain.

We present the case of a 45-year-old woman who was hospitalized due to severe macrocytic anemia and renal failure. The patient presented a morbid obesity. The immunological study showed anti-ENA anti-SSA (Ro52) positive, with negative antinuclear antibodies. Read More

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December 2018

Update on the epidemiology and disease outcome of Familial Mediterranean fever.

Authors:
Seza Özen

Best Pract Res Clin Rheumatol 2018 04 29;32(2):254-260. Epub 2018 Sep 29.

Department of Pediatrics, Hacettepe University, Ankara, Turkey. Electronic address:

Autoinflammatory diseases (AIDs) are diseases of the innate immune system, with clinical and laboratory evidence of attacks of inflammation. The more common AIDs are those associated with periodic fevers: Familial Mediterranean fever (FMF); Mevalonate Kinase Deficiency (MKD)/Hyperimmunoglobulin D Syndrome (HIDS); Cryopyrin-associated Autoinflammatory Syndrome (CAPS); and Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS). Classification criteria have been developed for all these types. Read More

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