5,359,177 results match your criteria Medicine & Science in Sports & Exercise[Journal]

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Neurofascin 140 and 155 antibodies in an atypical case of POEMS syndrome.

Muscle Nerve 2019 Apr 24. Epub 2019 Apr 24.

Dept. of Neurology, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610.

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http://dx.doi.org/10.1002/mus.26493DOI Listing

Chemoradiation induces epithelial-to-mesenchymal transition in esophageal adenocarcinoma.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Medical Oncology, Amsterdam, The NetherlandsRadiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam.

Multimodality treatment has advanced the outcome of esophageal adenocarcinoma (EAC), but overall survival remains poor. Therapeutic pressure activates effective resistance mechanisms and we characterized these mechanisms in response to the currently used neoadjuvant treatment against EAC; carboplatin, paclitaxel and radiotherapy. We developed an in vitro approximation of this regimen and applied it to primary patient-derived cultures. Read More

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http://dx.doi.org/10.1002/ijc.32364DOI Listing

PD-(L)1 Inhibitors Versus Chemotherapy Versus Their Combination in Front-line Treatment for NSCLC: An Indirect Comparison.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.

We comprehensively compared the therapeutic effects and safety of PD-1/L1 antibodies (I), chemotherapy (C) or their combination (I+C) as first-line treatments for advanced NSCLC. Online databases were searched to identify RCTs. Survival outcomes and safety events were pooled by indirect treatment comparison. Read More

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http://dx.doi.org/10.1002/ijc.32366DOI Listing

NK and T cell subsets in malignant mesothelioma patients: baseline pattern and changes in the context of anti-CTLA-4 therapy.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden.

Malignant mesothelioma (MM) is a highly aggressive form of cancer with limited treatment options. Although the role of NK cells has been studied in many solid tumors, the pattern of NK cell subsets and their recognition of mesothelioma cells remains to be explored. We used RNA expression data of MM biopsies derived from the cancer genome atlas to evaluate the immune cell infiltrates. Read More

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http://dx.doi.org/10.1002/ijc.32363DOI Listing

Fisetin and 5-Fluorouracil: Effective Combination for PIK3CA-Mutant Colorectal Cancer.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.

The normal colon epithelium is transformed into its neoplastic counterpart through a series of genetic alterations in driver genes including activating mutations in PIK3CA. Treatment often involves surgery followed by 5-fluorouracil (5-FU) based therapy, which has limited efficiency and serious side effects. We sought to determine whether fisetin, a dietary flavonoid, alone or in combination with 5-FU affected tumorigenesis in the mammalian intestine. Read More

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http://dx.doi.org/10.1002/ijc.32367DOI Listing

Re: Understanding quality of life impact in people with retinal vein occlusion: a qualitative inquiry.

Clin Exp Optom 2019 Apr 24. Epub 2019 Apr 24.

School of Medicine, Dentistry and Biomedical Science, Queen's University of Belfast, Belfast, UK.

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http://dx.doi.org/10.1111/cxo.12906DOI Listing

Impact of diagnosis and therapy on cognitive function in urea cycle disorders.

Ann Neurol 2019 Apr 24. Epub 2019 Apr 24.

Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.

Objective: Individuals with urea cycle disorders (UCDs) often present with intellectual and developmental disabilities. The major aim of this study was to evaluate the impact of diagnostic and therapeutic interventions on cognitive outcomes in UCDs.

Methods: This prospective, observational, multicenter study includes data from 503 individuals with UCDs who had comprehensive neurocognitive testing with a cumulative follow-up of 702 patient-years. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25492
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http://dx.doi.org/10.1002/ana.25492DOI Listing
April 2019
1 Read

MiR-16-1-3p and miR-16-2-3p possess strong tumor suppressive and anti-metastatic properties in osteosarcoma.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research-IMRIC, The Hebrew University-Hadassah Medical School at Ein-Kerem, Jerusalem, Israel.

Osteosarcoma (OS) is an aggressive malignancy affecting mostly children and adolescents. MicroRNAs (miRNAs) play important roles in OS development and progression. Here we found that miR-16-1-3p and miR-16-2-3p "passenger" strands as well as the "lead" miR-16-5p strand are frequently downregulated and possess strong tumor suppressive functions in human OS. Read More

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http://dx.doi.org/10.1002/ijc.32368DOI Listing

Successful use of an immune checkpoint inhibitor in a patient with myasthenia gravis in remission.

Muscle Nerve 2019 Apr 24. Epub 2019 Apr 24.

Department of Medicine IV, Hematology and Oncology, University of Halle.

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http://dx.doi.org/10.1002/mus.26495DOI Listing

Diabetes mellitus, genetic variants in the insulin-like growth factor pathway and colorectal cancer risk.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

Genetic variation in the insulin-like growth factor (IGF) pathway may further increase the risk of colorectal cancer (CRC) associated with type 2 diabetes mellitus (T2DM). Joint effects of T2DM and genetic variation in the IGF pathway on CRC risk can increase mechanistic insights. Participants from the Netherlands Cohort Study (n=120,852) completed a baseline questionnaire in 1986 when 55-69 years old (case-cohort, n subcohort=5,000, n cases = 3,441 after 16. Read More

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http://dx.doi.org/10.1002/ijc.32365DOI Listing

Spontaneous Early Resolution of an Iatrogenic Type A Aortic Dissection Following Coronary Angiography.

Aorta (Stamford) 2018 Dec 24;6(6):142-144. Epub 2019 Apr 24.

Department of Anesthesiology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.

A 74-year-old man was admitted with the diagnosis of non-ST-elevation myocardial infarction. During right coronary angiography, a coronary artery dissection extending into the proximal ascending aorta was noticed without hemodynamic compromise. Immediate computed tomography angiography showed no evidence of dissection in the ascending aorta. Read More

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http://dx.doi.org/10.1055/s-0039-1683956DOI Listing
December 2018

Head and Neck Pain in Patients Presenting with Acute Aortic Dissection.

Aorta (Stamford) 2018 Dec 24;6(6):130-138. Epub 2019 Apr 24.

Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan.

Background:  Head and neck pain is an atypical presentation of acute aortic dissection. Classic teaching associates this pain with proximal dissections, but this has not been extensively studied.

Methods:  Patients enrolled in the International Registry of Acute Aortic Dissection from January 1996 to March 2015 were included in this study. Read More

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http://dx.doi.org/10.1055/s-0039-18388DOI Listing
December 2018

A Case of Chronic and Relapsing Paget Disease of the Vulva.

Rev Bras Ginecol Obstet 2019 Apr 24. Epub 2019 Apr 24.

Department of Dermatovenereology, Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria, Lisboa, Portugal.

Extramammary Paget disease is a rare neoplastic condition that more commonly affects postmenopausal Caucasian women. Although the vulvar area is the most frequently affected location, it corresponds solely to 1 to 2% of all vulvar malignancies. A 72-year-old female patient was observed in our outpatient clinic with a 2-year history of an erythematous and pruritic plaque on the vulva. Read More

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http://dx.doi.org/10.1055/s-0039-1687861DOI Listing
April 2019
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Long-term Outcomes of Microvascular Decompression in the Treatment of Hemifacial Spasm Based on Different Offending Vessels.

J Neurol Surg A Cent Eur Neurosurg 2019 Apr 24. Epub 2019 Apr 24.

Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, Xinhua Hospital, Shanghai, China.

Objective:  To evaluate clinical features, outcomes, and complications in patients with hemifacial spasm (HFS) after microvascular decompression (MVD) of different offending vessels.

Methods:  Clinical data were collected from 362 patients with HFS treated with MVD between January 2013 and January 2014. Patients were divided into five groups based on the offending vessel: A (anterior inferior cerebellar artery [AICA] compression), B (posterior inferior cerebellar artery [PICA] compression), C (AICA plus PICA compression), D (vertebral artery [VA] compression), and E (VA plus small vessel compression). Read More

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http://dx.doi.org/10.1055/s-0039-1685199DOI Listing

Reducing Surgeon's Physical Stress in Minimally Invasive Neurosurgery.

J Neurol Surg A Cent Eur Neurosurg 2019 Apr 24. Epub 2019 Apr 24.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background And Study Aims:  Various minimally invasive approaches are used in neurosurgery. Surgeons must perform nondynamic fine movements in a narrow corridor, so specially designed surgical devices are essential. Unsophisticated instruments may pose potential hazards. Read More

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http://dx.doi.org/10.1055/s-0038-1676622DOI Listing
April 2019
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Platelet Activation by Antiphospholipid Antibodies Depends on Epitope Specificity and is Prevented by mTOR Inhibitors.

Thromb Haemost 2019 Apr 24. Epub 2019 Apr 24.

Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany.

Antiphospholipid antibodies (aPL) have been reported to activate platelets. This is considered to be one of the pathogenic properties of aPL. Even though aPL heterogeneity is quite well established, little is known, if the ability to activate platelets is common to all aPL or depends on antigen specificity. Read More

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http://dx.doi.org/10.1055/s-0039-1685453DOI Listing

Quercus ilex Extract Ameliorates Acute TNBS-Induced Colitis in Rats.

Planta Med 2019 Apr 24. Epub 2019 Apr 24.

Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain.

L. (Fagaceae) is one of the most commonly used plants in folk medicine in the Mediterranean region to treat gastrointestinal disorders. The aim of the present study was to evaluate the effects of a polyphenol extract from mature leaves of on acute 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats. Read More

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http://dx.doi.org/10.1055/a-0889-6132DOI Listing

Assessing Inspiratory Muscle Strength for Early Detection of Respiratory Failure in Motor Neuron Disease: Should We Use MIP, SNIP, or Both?

Respiration 2019 Apr 24:1-11. Epub 2019 Apr 24.

Division of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland.

Background: Motor neuron disease (MND) invariably impacts on inspiratory muscle strength leading to respiratory failure. Regular assessment of sniff nasal inspiratory pressure (SNIP) and/or maximal mouth inspiratory pressure (MIP) contributes to early detection of a requirement for ventilatory support.

Objectives: The aim of this study was to compare the feasibility, agreement, and performance of both tests in MND. Read More

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http://dx.doi.org/10.1159/000498972DOI Listing

Sepsis-Associated Acute Kidney Injury: A Problem Deserving of New Solutions.

Nephron 2019 Apr 24:1-5. Epub 2019 Apr 24.

Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Sepsis-associated acute kidney injury (S-AKI) significantly worsens patient prognosis, and recent evidence suggests that the injury process begins early and may be sustained by therapies used to treat the sepsis (e.g., fluids resuscitation, antibiotics). Read More

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https://www.karger.com/Article/FullText/500167
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http://dx.doi.org/10.1159/000500167DOI Listing
April 2019
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Pleural Cryobiopsy versus Flexible Forceps Biopsy in Subjects with Undiagnosed Exudative Pleural Effusions Undergoing Semirigid Thoracoscopy: A Crossover Randomized Trial (COFFEE Trial).

Respiration 2019 Apr 24:1-9. Epub 2019 Apr 24.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India,

Background: There is no randomized study comparing pleural cryobiopsy (CB) and flexible forceps biopsy (FFB) in subjects undergoing medical thoracoscopy for the diagnosis of pleural effusions.

Objective: In this crossover study, we compared the diagnostic yield of CB versus FFB in subjects undergoing semirigid thoracoscopy.

Methods: Subjects undergoing semirigid thoracoscopy for undiagnosed pleural effusions were subjected to both CB and FFB, with the order of performing the biopsy randomized in a 1:1 ratio. Read More

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http://dx.doi.org/10.1159/000497212DOI Listing

The Protective Roles of Folic Acid in Preventing Diabetic Retinopathy Are Potentially Associated with Suppressions on Angiogenesis, Inflammation, and Oxidative Stress.

Ophthalmic Res 2019 Apr 24:1-13. Epub 2019 Apr 24.

The First Clinical Medical College of Lanzhou University, Lanzhou, China.

This study aimed to evaluate the therapeutic effect of folic acid (FA) on diabetic retinopathy (DR) in a genetic mouse model of obese type 2 diabetes mellitus (T2D). C57BL/KsJ-db/db (db/db) T2D mice were divided into control, FA, metformin (MET), and FA plus MET groups (n = 10/group). Serum levels of glucose, glycated hemoglobin, and insulin were determined weekly. Read More

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http://dx.doi.org/10.1159/000499020DOI Listing

Autophagy in Pulmonary Innate Immunity.

J Innate Immun 2019 Apr 24:1-10. Epub 2019 Apr 24.

Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

Autophagy is a major intracellular digestion system that delivers cytoplasmic components for degradation and recycling. In this capacity, autophagy plays an important role in maintaining cellular homeostasis by mediating the degradation of cellular macromolecules and dysfunctional organelles and regeneration of nutrients for cell growth. Autophagy is important in innate immunity, as it is responsible for the clearance of various pathogens. Read More

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http://dx.doi.org/10.1159/000497414DOI Listing
April 2019
2 Reads

Role of Ancillary Techniques in Fluid Cytology.

Acta Cytol 2019 Apr 24:1-11. Epub 2019 Apr 24.

Hospital of the University of Pennsylvania, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

The cytologic evaluation of serous effusions may be challenging for a number of reasons. Distinction of benign, reactive conditions from malignancy represents the main focus when examining these specimens. The morphologic diagnosis of malignancy may be difficult due to the relative paucity of abnormal cells. Read More

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http://dx.doi.org/10.1159/000496568DOI Listing

No Difference in Prevalence of Transmitted Drug Resistance between Injection Drug Users and Non-Injection Drug Users: A Cross-Sectional Study among Antiretroviral Treatment-Naïve HIV Patients.

Intervirology 2019 Apr 24:1-11. Epub 2019 Apr 24.

Guangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning, China,

Objectives: The epidemiological evidence is inconsistent about whether HIV-positive injection drug users (IDUs) are at higher risk of developing antiretroviral resistance than any other HIV-positive populations. This study aims to investigate and compare transmitted drug resistance (TDR) between IDUs and non-IDUs in Lingshan County, an HIV-hit region in Guangxi, China, where IDU and heterosexual transmission were the two dominant transmission routes and roughly equally contributed to the local HIV transmission.

Methods: A cross-sectional study was conducted among newly diagnosed and antiretroviral-treatment (ART)-naïve HIV-1 patients from Lingshan County. Read More

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https://www.karger.com/Article/FullText/499367
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http://dx.doi.org/10.1159/000499367DOI Listing
April 2019
5 Reads

Systemic Pseudohypoaldosteronism Type 1 due to 3 Novel Mutations in SCNN1Aand SCNN1BGenes.

Horm Res Paediatr 2019 Apr 24:1-11. Epub 2019 Apr 24.

Department of Paediatric Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Objective: The systemic form of pseudohypoaldosteronism type 1 (PHA1) is an autosomal recessive disorder characterized by defective sodium transport in multi-organ systems. Mutations in the genes encoding the amiloride-sensitive epithelial sodium channel, ENaC, account for genetic causes of systemic PHA1. We describe systemic PHA1 due to 4 novel variants detected in SCNN1A and SCNN1B in 3 cases from 3 unrelated consanguineous families. Read More

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http://dx.doi.org/10.1159/000498860DOI Listing

Different Psychosocial Factors Are Associated with Seasonal and Perennial Allergies in Adults: Cross-Sectional Results of the KORA FF4 Study.

Int Arch Allergy Immunol 2019 Apr 24:1-11. Epub 2019 Apr 24.

Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum München, Augsburg, Germany,

Background: Psychosocial factors are supposed to play a central role in the development of allergic diseases. Associations with seasonal and perennial forms of allergies have not been investigated, yet.

Objectives: The aim of the study was to investigate the associations of psychosocial factors (social status, depression, generalized anxiety, psychosocial stress, Type-D personality) with seasonal, perennial, and other forms of allergies in adults. Read More

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https://www.karger.com/Article/FullText/499042
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http://dx.doi.org/10.1159/000499042DOI Listing
April 2019
1 Read

Dosimetric response of fabricated Ge-doped optical fibres in computed tomography RQT beam quality X-ray beams.

J Radiol Prot 2019 Apr 24. Epub 2019 Apr 24.

Imaging, University Putra Malaysia, Department of Imaging, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Serdang, 43400, MALAYSIA.

Novel germanium (Ge)-doped silica glass fibres tailor-made in Malaysia are fast gaining recognition as potential media for thermoluminescence (TL) dosimetry, with active research ongoing into exploitation of their various beneficial characteristics. Investigation is made herein of the capability of these media for use in diagnostic imaging dosimetry, specifically at the radiation dose levels typically obtained in conduct of Computed Tomography (CT). As a first step within such efforts, there is need to investigate the performance of the fibres using tightly defined spectra, use being made of a Philips constant potential industrial X-Ray facility, Model MG165, located at the Malaysian Nuclear Agency Secondary Standards Dosimetry Lab (SSDL). Read More

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http://dx.doi.org/10.1088/1361-6498/ab1c16DOI Listing

Parameterizing and validating existing algorithms for identifying out-of-bed time using hip-worn accelerometer data from older women.

Physiol Meas 2019 Apr 24. Epub 2019 Apr 24.

Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, UNITED STATES.

Objective: To parameterize and validate two existing algorithms for identifying out-of-bed time using 24-hour hip-worn accelerometer data from older women. 
 
 Approach: Overall, 628 women (80±6 years old) wore ActiGraph GT3X+ accelerometers 24 hours/day for up to 7 days and concurrently completed sleep-logs. Trained staff used a validated visual analysis protocol to measure in-bed periods on accelerometer tracings (criterion). Read More

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http://iopscience.iop.org/article/10.1088/1361-6579/ab1c04
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http://dx.doi.org/10.1088/1361-6579/ab1c04DOI Listing
April 2019
1 Read

Emergency medicine board pass rates and medical residents' experiences following the introduction of the small group learning approach in Qatar.

Int J Med Educ 2019 Apr 24;10:88-89. Epub 2019 Apr 24.

Department of Emergency medicine, Hamad General Hospital, Doha, Qatar.

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http://dx.doi.org/10.5116/ijme.5cb2.e936DOI Listing

Higher urinary cortisol levels associated with increased cardiovascular risk.

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

G Williams, Medicine/Endocrinology, Brigham and Women's Hospital, Boston, 02115, United States.

There is conflicting data on whether variations of physiologic cortisol levels associate with cardiovascular risk. We hypothesize that prior discordant findings are related to problems associated with varying sample size, techniques for assessing cardiovascular risk, and failure to adequately account for environmental factors. We utilized a large sample size, selected the Framingham risk score to compute cardiovascular risk, and performed the study in a highly controlled setting. Read More

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http://dx.doi.org/10.1530/EC-19-0182DOI Listing

Lobectomy in patients with differentiated thyroid cancer: indications and follow-up.

Endocr Relat Cancer 2019 Apr 1. Epub 2019 Apr 1.

J Yoon, Department of Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea (the Republic of).

The extent of thyroid surgery for patients with low- and intermediate-risk differentiated thyroid carcinoma (DTC), with a primary tumour <4 cm and no extrathyroidal extension (ETE) or lymph node (LN) metastases, has shifted in a more conservative direction. However, clinicopathological risk factors, including microscopic ETE, aggressive histology, vascular invasion in papillary thyroid carcinoma (PTC), and intermediate volume of LN metastases, can only be identified after completing thyroid lobectomy. It is controversial whether patients with these risk factors should immediately undergo complete thyroidectomy and/or radioactive iodine remnant ablation, or should be monitored without further treatments. Read More

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http://dx.doi.org/10.1530/ERC-19-0085DOI Listing

Testosterone inhibits aneurysm formation and vascular inflammation in male mice.

J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

M Akishita, Department of Geriatric Medicine, University of Tokyo, Tokyo, Japan.

Abdominal aortic aneurysm (AAA), one of the pathological phenotypes of vascular aging, is characterized by aortic dilation with impaired arterial wall integrity. Recent epidemiologic studies have shown that men with AAA have lower serum testosterone (T) compared to men without. However, the underlying mechanisms remain unclear. Read More

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http://dx.doi.org/10.1530/JOE-18-0646DOI Listing

Glucocorticoids and programming of the microenvironment in heart.

J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

L Zhang, Basic Sciences, Loma Linda University School of Medicine, Loma Linda, United States.

Glucocorticoids are primary stress hormones and can improve neonatal survival when given to pregnant women threatened by preterm birth or to preterm infants. It has become increasingly apparent that glucocorticoids, primarily through interacting with glucocorticoid receptors, play a critical role in late gestational cardiac maturation. Altered glucocorticoid actions contribute to the development and progression of heart disease. Read More

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http://dx.doi.org/10.1530/JOE-18-0672DOI Listing

Hospitalization Burden of Biliary Strictures and Cholangitis After Pancreaticoduodenectomy.

J Surg Res 2019 Apr 21;241:95-102. Epub 2019 Apr 21.

Division of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, New Jersey.

Background: Postsurgical biliary disease in Roux-en-y and cholecystectomies has been investigated, but less literature exists regarding biliary complications after Whipple procedure (pancreaticoduodenectomy [PD]). Moreover, the hospital burden incurred after this complication has not been previously examined. The aim of this study is to assess the trends in hospitalization for biliary strictures and cholangitis after PD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193017
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http://dx.doi.org/10.1016/j.jss.2019.03.057DOI Listing
April 2019
4 Reads

Waitlist Mortality of Amyloid Cardiomyopathy Patients Listed for Heart Transplantation and Implications for Organ Allocation.

J Card Fail 2019 Apr 21. Epub 2019 Apr 21.

Department of Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, United States. Electronic address:

Background: While outcomes of patients with amyloid cardiomyopathy (ACM) undergoing heart transplantation have been reported, there is scant data on the waitlist mortality of these patients. The aim of this study was to investigate whether patients with amyloid cardiomyopathy have higher waitlist mortality compared to those with other types of cardiomyopathies.

Methods: We queried the United Network for Organ Sharing (UNOS) registry for all patients (age ≥ 18 years) listed for heart transplantation between 2008 and 2015. Read More

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http://dx.doi.org/10.1016/j.cardfail.2019.04.011DOI Listing
April 2019
2 Reads

Effect of cold hip baths on blood glucose levels in patients with type 2 diabetes mellitus: a pilot study.

Diabetes Metab 2019 Apr 21. Epub 2019 Apr 21.

Assitant Medical Officer/Lecturer-II, Department of Yoga, Govt. Yoga and Naturopathy Medical College and Hospital, Arumbakkam, Chennai, Tamil Nadu, India.

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http://dx.doi.org/10.1016/j.diabet.2019.04.003DOI Listing

Strategy focused on clinical parameters of microcirculation to resuscitate patients in septic shock: do not forget any tools.

Anaesth Crit Care Pain Med 2019 Apr 21. Epub 2019 Apr 21.

Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.

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http://dx.doi.org/10.1016/j.accpm.2019.04.009DOI Listing

Impact of Adjuvant Chemotherapy on Oncologic Outcomes following Radical Nephroureterectomy for Patients with pT3NanyM0 Upper Tract Urothelial Carcinoma: A retrospective cohort study.

Int J Surg 2019 Apr 21. Epub 2019 Apr 21.

Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Electronic address:

Objective: We investigated the impact of cisplatin-based adjuvant chemotherapy (AC) on oncologic outcomes including recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS) after radical nephroureterectomy (RNU) for patients with pT3NanyM0 upper tract urothelial carcinoma (UTUC).

Methods: We retrospectively reviewed 293 patients who underwent RNU for UTUC between 1995 and 2017. Clinicopathologic characteristics of patients were examined and compared according to the use of AC. Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.04.013DOI Listing

Implications of the mitochondrial interactome of mammalian thioredoxin 2 for normal cellular function and disease.

Free Radic Biol Med 2019 Apr 21. Epub 2019 Apr 21.

Department of Chemistry, University of Patras, Rion 26504, Greece. Electronic address:

Multiple thioredoxin isoforms exist in all living cells. To explore the possible functions of mammalian mitochondrial thioredoxin 2 (Trx2), an interactome of mouse Trx2 was initially created using (i) a monothiol mouse Trx2 species for capturing protein partners from different organs and (ii) yeast two hybrid screens on human liver and rat brain cDNA libraries. The resulting interactome consisted of 195 proteins (Trx2 included) plus the mitochondrial 16S RNA. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.018DOI Listing

Inhibition of Rac1 activity alleviates PM2.5-induced pulmonary inflammation via the AKT signaling pathway.

Toxicol Lett 2019 Apr 21. Epub 2019 Apr 21.

The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China. Electronic address:

PM2.5 is the main particulate air pollutant that is capable of inducing airway injury. Previous studies have indicated that Rac1 is involved in cigarette smoke-induced lung inflammation and lipopolysaccharide-mediated pulmonary injury. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.04.017DOI Listing

FA-NBs-IR780: Novel multifunctional nanobubbles as molecule-targeted ultrasound contrast agents for accurate diagnosis and photothermal therapy of cancer.

Cancer Lett 2019 Apr 21. Epub 2019 Apr 21.

Department of Ultrasound Medicine, Tang Du Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710038, China. Electronic address:

Early accurate diagnosis and targeted therapy for cancer are essential to improve the prognosis of patients. With the emergence of molecular imaging, molecule-targeted ultrasound imaging for the non-invasive and precise detection of cancer has attracted increased attention. The investigation of molecule-targeted ultrasound contrast agents (UCAs) with excellent performance is urgently needed. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.04.023DOI Listing

Activation of liver x receptors prevents the spinal LTP induced by skin/muscle retraction in the thigh via SIRT1/NF-Κb pathway.

Neurochem Int 2019 Apr 21. Epub 2019 Apr 21.

Department of Physiology and Pain Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, PR China; Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, Guangdong, PR China. Electronic address:

It has been reported that skin/muscle incision and retraction (SMIR) in the thigh, produces mechanical allodynia in the hind paw, far from the site of incision/retraction. The mechanical allodynia lasts about 22 days, indicating chronic post-operative pain develops. The precise mechanisms, however, are largely unclear. Read More

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http://dx.doi.org/10.1016/j.neuint.2019.04.002DOI Listing

Chemical composition and cytotoxic screening of Musa cavendish green peels extract: Antiproliferative activity by activation of different cellular death types.

Toxicol In Vitro 2019 Apr 21. Epub 2019 Apr 21.

Emergency Medicine Department, Medical School, University of São Paulo, Av. Dr. Arnaldo, 455 - Cerqueira César, São Paulo, São Paulo CEP 01246-903, Brazil.

Musa cavendish, commonly known as banana, is a fruit with nutritional and therapeutic properties. We investigated the chemical composition and in vitro cytotoxic effect of M. cavendish green peel extract (MHE) on cancer cells for the first time. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.04.020DOI Listing

Analgesic and anti-inflammatory effects and molecular mechanisms of Kadsura heteroclita stems, an anti-arthritic Chinese Tujia ethnomedicinal herb.

J Ethnopharmacol 2019 Apr 21:111902. Epub 2019 Apr 21.

TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, PR China. Electronic address:

Ethnopharmacological Relevance: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by failure of spontaneous resolution of inflammation. The stem of Kadsura heteroclite (KHS) is a well-known anti-arthritic Tujia ethnomedicinal plant, which named Xuetong in folk, has long been used for the prevention and treatment of rheumatic and arthritic diseases.

Aim Of The Study: The analgesic and anti-inflammatory effects and the potential mechanisms behind such effects of KHS would be investigated by using different animal models. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111902DOI Listing

Notch Signaling Mediates Secondary Senescence.

Cell Rep 2019 Apr;27(4):997-1007.e5

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK. Electronic address:

Oncogene-induced senescence (OIS) is a tumor suppressive response to oncogene activation that can be transmitted to neighboring cells through secreted factors of the senescence-associated secretory phenotype (SASP). Currently, primary and secondary senescent cells are not considered functionally distinct endpoints. Using single-cell analysis, we observed two distinct transcriptional endpoints, a primary endpoint marked by Ras and a secondary endpoint marked by Notch activation. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.104DOI Listing

The Integrator Complex Prevents Dedifferentiation of Intermediate Neural Progenitors back into Neural Stem Cells.

Cell Rep 2019 Apr;27(4):987-996.e3

Neuroscience & Behavioral Disorders Programme, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. Electronic address:

Mutations of the Integrator subunits are associated with neurodevelopmental disorders and cancers. However, their role during neural development is poorly understood. Here, we demonstrate that the Drosophila Integrator complex prevents dedifferentiation of intermediate neural progenitors (INPs) during neural stem cell (neuroblast) lineage development. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.089DOI Listing

Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis.

Cell Rep 2019 Apr;27(4):1277-1292.e7

Department of Pathology, Yale University School of Medicine, New Haven, CT, USA; Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT, USA; Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

The brain is a major site of relapse for several cancers, yet deciphering the mechanisms of brain metastasis remains a challenge because of the complexity of the brain tumor microenvironment (TME). To define the molecular landscape of brain metastasis from intact tissue in vivo, we employ an RNA-sequencing-based approach, which leverages the transcriptome of xenografts and distinguishes tumor cell and stromal gene expression with improved sensitivity and accuracy. Our data reveal shifts in epithelial and neuronal-like lineage programs in malignant cells as they adapt to the brain TME and the reciprocal neuroinflammatory response of the stroma. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.085DOI Listing

Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma.

Cell Rep 2019 Apr;27(4):1265-1276.e4

Division of Pharmacotherapeutics, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Biliary tract carcinomas (BTCs) are among the most aggressive malignancies and have a poor prognosis. Here, we successfully established organoid lines derived from intrahepatic cholangiocarcinoma, gallbladder cancer, and neuroendocrine carcinoma of the ampulla of Vater. These organoids derived from BTCs were cultured stably for >1 year and closely recapitulated the histopathology, gene expression, and genetic alterations evident in the primary tumors. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.088DOI Listing
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