5,277,572 results match your criteria Medicine & Science in Sports & Exercise[Journal]

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[Predictive value of white blood cell, procalcitonin and high-sensitivity C-reactive protein for the bloodstream infection in the super-elderly critically-ill patients].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):365-369

Department of Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.

To investigate the ability of white blood cell (WBC), procalcitonin (PCT) and high-sensitivity C-reactive protein (hs-CRP) in the super-elderly patients with bloodstream infection. It was a retrospective study. A total of 77 patients (≥85 years) admitted to the ICU of Peking Union Medical College Hospital from June, 2016 to December, 2017 were enrolled. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.009DOI Listing
January 2019
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[Quantitative evaluation of intravoxel incoherent motion diffusion-weighted imaging and three-dimensional arterial spin labeling in Ki-67 labeling index and grading of brain gliomas].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):338-342

Department of Pathology, Li Huili Hospital, Ningbo Medical Center, Ningbo 315040, China.

To investigate the value of multiple parameters derived from intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and three-dimensional arterial spin labeling (3D-ASL) in Ki-67 labeling index (Ki-67 LI) and grading of human brain gliomas. From December 2015 to May 2018, 45 patients of gliomas confirmed by surgical pathology in Li Huili Hospital, Ningbo Medical Center were divided into low-grade group (20 cases of WHO grade Ⅱ) and high-grade group (12 cases of WHO grade Ⅲ, 13 cases of WHO grade Ⅳ), and the Ki-67 LI of glioma was obtained by immunohistochemistry. All patients, 24 males and 21 females, aged 25-83 years, mean(53±12)years, underwent conventional magnetic resonance imaging (MRI), IVIM-DWI and 3D-ASL before operation, then measured the true water diffusion coefficient (D), microcirculation perfusion coefficient (D(*)), perfusion fraction (f) and cerebral blood flow (CBF) in the tumor solid area and the contralateral normal white matter area. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.004DOI Listing
January 2019

[Magnetic resonance imaging study of endolymphatic hydrops based on 3D-FLAIR sequence after single-dose intravenous gadolinium injection].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):333-337

Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

To investigate the visualization of endolymph in patients with otogenic vertigo by intravenous administration of single dose of gadolinium contrast agents and magnetic resonance three-dimensional fluid-attenuated inversion recovery sequence (3D-FLAIR MRI), and further assess the extent of endolymphatic hydrops. From Beijing Tongren Hospital of Capital Medical University between October 2017 and June 2018, 30 patients (16 males, 14 females) with unilateral otogenic vertigo were involved in this study, with the age of 30 to 68 years, mean age of (53±10) years. Eight hours after intravenous administration of single dose (0. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.003DOI Listing
January 2019

Inadvertent Rapid Lipid Emulsion Administration.

Isr Med Assoc J 2019 Feb;21(2):129-130

Institute of Gastroenterology, Nutrition, and Liver Disease, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.

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February 2019

Bilateral Diaphragmatic Paralysis: A Rare but not to be Neglected Cause of Dyspnea.

Isr Med Assoc J 2019 Feb;21(2):126-129

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Israel.

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February 2019

Immunoglobulin G4-Related Disease Presenting with Clinical Similarity to Churg-Strauss Syndrome.

Isr Med Assoc J 2019 Feb;21(2):124-125

Department of Internal Medicine, Meir Medical Center, Kfar Saba, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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February 2019

IgG4-Related Disease and Eosinophilic Granulomatosis with Polyangiitis: Similarity or Coexistence?

Isr Med Assoc J 2019 Feb;21(2):122-123

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel.

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February 2019

Acute Stroke and Attenuation in Endothelial Progenitor Cells: Cause or Effect?

Isr Med Assoc J 2019 Feb;21(2):120-121

Department of Cardiology, Assuta Ashdod Medical Center, Ashdod, affiliated with Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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February 2019

Ultrasound-Guided Botulinum Toxin Injections into the Salivary Glands for the Treatment of Drooling.

Isr Med Assoc J 2019 Feb;21(2):116-119

Department of Oral and Maxillofacial Surgery, Sheba Medical Center, Tel Hashomer, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Drooling is the unintentional loss of saliva from the mouth, usually caused by poor coordination of the swallowing mechanism. It is commonly seen in patients with chronic neurologic disorders, such as Parkinson's disease, amyotrophic lateral sclerosis (ALS), cerebral palsy, and stroke, as well as in patients with cognitive impairment and dementia.

Objectives: To evaluate the efficacy and safety of ultrasound-guided botulinum toxin injections into the parotid and submandibular salivary glands for the treatment of drooling. Read More

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February 2019

Hospitalization for Respiratory Syncytial Virus Bronchiolitis in the Palivizumab Prophylaxis Era: Need for Reconsideration of Preventive Timing and Eligibility.

Isr Med Assoc J 2019 Feb;21(2):110-115

Department of Pediatrics A, Schneider Children's Medical Center, Petah Tikva, Israel.

Background: Respiratory syncytial virus (RSV)-related bronchiolitis is a common cause of morbidity in young infants. The recommendations for its passive prevention by palivizumab are currently under intensive debate.

Objectives: To elucidate the optimal prevention strategy by studying the morbidity of RSV disease under the current recommendations for palivizumab prophylaxis in Israel. Read More

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February 2019

Nationwide Survey of Intratympanic Steroids for the Management of Sudden Sensorineural Hearing Loss.

Isr Med Assoc J 2019 Feb;21(2):105-109

Department of Otolaryngology - Head and Neck Surgery, Western Galilee Medical Center, Nahariya, Israel.

Background: The currently accepted treatment for idiopathic sudden sensorineural hearing loss (ISSHL) is systemic steroids as first-line and intratympanic steroids as salvage therapy. Intratympanic (IT) treatment is applied worldwide in many different ways with no universally accepted protocol.

Objectives: To present the current disparity in ISSHL management and to discuss the necessity for establishing a common national protocol. Read More

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February 2019

Ga-PSMA PET/CT Staging of Newly Diagnosed Intermediate- and High-Risk Prostate Cancer.

Isr Med Assoc J 2019 Feb;21(2):100-104

Department of Nuclear Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Ga-prostate-specific membrane antigen positron emission tomography/computerized tomography (Ga-PSMA PET/CT) is part of the initial workup of patients with intermediate and high-risk prostate cancer provided by the Israeli national health services.

Objectives: To assess the incidence of metastatic spread in consecutive patients with newly diagnosed cancer, and the potential added value of Ga-PSMA PET/CT to the staging imaging algorithm.

Methods: Patients with newly diagnosed intermediate- and high-risk prostate cancer were referred for initial staging by Ga-PSMA PET/CT between May 2016 and April 2017. Read More

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February 2019

Hyperchloremia and Diuresis in Children Undergoing Scoliosis Surgery: A Retrospective Cohort Study.

Isr Med Assoc J 2019 Feb;21(2):94-99

Division of Anesthesiology, Critical Care and Pain Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Hyperchloremia is frequent in adult surgical patients and is associated with renal dysfunction. Studies in surgical pediatric patients are lacking.

Objectives: To identify both the incidence of postoperative hyperchloremia in children undergoing surgery for idiopathic and non-idiopathic scoliosis, and the association of postoperative hyperchloremia with intraoperative fluid management and postoperative diuresis. Read More

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February 2019

Maternal and Neonatal Complications of Pregnant Women with Mitral Stenosis.

Isr Med Assoc J 2019 Feb;21(2):88-93

Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel.

Background: Rheumatic mitral stenosis (MS) is a relatively rare diagnosis in the developed countries and its treatment during pregnancy is challenging due to hemodynamic changes. With the demographic changes due to recent waves of immigration an increase in the prevalence of rheumatic heart disease is expected.

Objectives: To evaluate maternal and neonatal complications in patients with mitral stenosis. Read More

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February 2019

Unilateral Renal Agenesis Diagnosed on Early Prenatal Trans-Vaginal Scans.

Isr Med Assoc J 2019 Feb;21(2):85-87

Department of Obstetrics and Gynecology, Rambam Medical Center, affiliated with Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background: Unilateral renal agenesis is a rare finding. There are no large-scale studies reporting this finding in early pregnancy.

Objectives: To evaluate the incidence of unilateral renal agenesis (URA) and of associated anomalies diagnosed by early prenatal trans-vaginal sonography. Read More

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February 2019

Comparative Study of Frozen and Paraffin-Embedded Sections: Evaluation of Inflammatory Dermatoses.

Isr Med Assoc J 2019 Feb;21(2):82-84

Department of Dermatology, Sourasky Tel Aviv Medical Center, Tel Aviv, Israel.

Background: Frozen section (FS) is often performed when histopathological evaluations are urgently required for implementation of therapeutic measures. In dermatology, this method is most commonly used to evaluate excision margins of tumors. FS are also routinely employed to differentiate toxic epidermal necrolysis from staphylococcal scalded skin syndrome. Read More

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February 2019

Case-Control Retrospective Study of Child Sexual Abuse History among Psychiatric Consultations in a General Hospital Emergency Room.

Isr Med Assoc J 2019 Feb;21(2):77-81

Department of Consultation and Liaison Psychiatry, Shaare Zedek Medical Center, Jerusalem, Israel.

Background: A history of childhood sexual abuse (CSA) has been linked to a variety of physical and psychiatric illnesses, including ischemic heart disease and post-traumatic stress disorder (PTSD).

Objectives: To determine the prevalence of past CSA and re-traumatization among hospital psychiatric consultations and to determine whether a CSA group in a hospital setting shared characteristics with community samples described in the literature.

Methods: We divided 228 consecutive psychiatric consultations into two groups. Read More

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February 2019

Inhibition of endothelial Progenitor Cells Inhibition in the first 24 hours of an Acute Ischemic Cerebrovascular Event.

Isr Med Assoc J 2019 Feb;21(2):71-76

Department of Medicine, Padeh Medical Center, Poriya, Israel.

Background: Endothelial progenitor cells may have a role in ongoing endothelial repair. Impaired mobilization or depletion of these cells may contribute to progression of vascular disease. Our hypothesis was that endothelial progenitor cells would be suppressed in patients with acute cerebrovascular event based on our previous study that found severe endothelial dysfunction in those patients. Read More

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February 2019

Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats.

J Cell Mol Med 2019 Feb 17. Epub 2019 Feb 17.

Department of Central Laboratory, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.

Peripheral nerve injury results in limited nerve regeneration and severe functional impairment. Mesenchymal stem cells (MSCs) are a remarkable tool for peripheral nerve regeneration. The involvement of human umbilical cord MSC-derived extracellular vesicles (hUCMSC-EVs) in peripheral nerve regeneration, however, remains unknown. Read More

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http://dx.doi.org/10.1111/jcmm.14190DOI Listing
February 2019

Local oestrogen therapy modulates extracellular matrix and immune response in the vaginal tissue of post-menopausal women with severe pelvic organ prolapse.

J Cell Mol Med 2019 Feb 17. Epub 2019 Feb 17.

Department of Physiology, University of Toronto, Toronto, ON, Canada.

This study investigates the effect of local oestrogen therapy (LET) on the expression of proteins participating in collagen/elastin biogenesis and immune markers in vaginal tissues of post-menopausal women with severe pelvic organ prolapse (POP). Vaginal biopsies were collected from the anterior vaginal wall of informed and consented 52 post-menopausal women with severe POP undergoing total hysterectomy. Twenty-nine of the 52 women were treated with LET (in the form of vaginal oestrogen cream or tablet), while the remaining 23 untreated patients served as the controls. Read More

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http://dx.doi.org/10.1111/jcmm.14199DOI Listing
February 2019

Contemporary Concise Review 2018: Lung cancer and pleural disease.

Respirology 2019 Feb 16. Epub 2019 Feb 16.

Department of Respiratory Medicine, Royal Brompton Hospital, London, UK.

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http://dx.doi.org/10.1111/resp.13499DOI Listing
February 2019

Nutrition and its role in human evolution.

J Intern Med 2019 Feb 17. Epub 2019 Feb 17.

Vice Chancellor and Dean for Agriculture and Life Sciences, Texas A&M AgriLife, College Station, TX, USA.

Our understanding of human evolution has improved rapidly over recent decades, facilitated by large-scale cataloguing of genomic variability amongst both modern and archaic humans. It seems clear that the evolution of the ancestors of chimpanzees and hominins separated 7-9 million years ago with some migration out of Africa by the earlier hominins; Homo sapiens slowly emerged as climate change resulted in drier, less forested African conditions. The African populations expanded and evolved in many different conditions with slow mutation and selection rates in the human genome, but with much more rapid mutation occurring in mitochondrial DNA. Read More

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http://dx.doi.org/10.1111/joim.12878DOI Listing
February 2019

Potential role of Anitschkow cells in cardiovascular disease in human and veterinary medicine: A review of the literature.

Anat Histol Embryol 2019 Feb 17. Epub 2019 Feb 17.

Department of Veterinary Sciences, University of Turin, Grugliasco, Turin, Italy.

Anitschkow cells (AC) are a peculiar type of stromal cells observed in myocardium, cardiac valves and coronary vessels wall whose origin, characterization and role remain controversial. In human heart, they represent a histological hallmark of Aschoff nodules in rheumatic fever, but they have also been observed in other myocardial pathologies. Firstly, they have been considered a myocyte-derived cells, but light microscopy, immunohistochemical and ultrastructural studies pointed out that a macrophagic/histiocytic origin cannot be excluded. Read More

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http://dx.doi.org/10.1111/ahe.12433DOI Listing
February 2019

Vertebral heart size in healthy Australian cattle dog.

Anat Histol Embryol 2019 Feb 17. Epub 2019 Feb 17.

Department of Veterinary Medicine, Agroveterinary Sciences Center, State University of Santa Catarina (CAV / UDESC), Lages, Brazil.

The vertebral heart score or size (VHS) measurement is routinely used to provide a more objective measurement of cardiomegaly in dogs. However, breed or body conformation can influence the VHS. To assess the specific VHS for the Australian Cattle Dog, left-to-right lateral, right-to-left lateral, dorsoventral and ventrodorsal thoracic radiographs from 20 individuals free from cardiac and pulmonary disease were obtained. Read More

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http://dx.doi.org/10.1111/ahe.12434DOI Listing
February 2019

Iodine status of Indigenous and non-Indigenous young adults in the Top End, before and after mandatory fortification.

Med J Aust 2019 Feb 7;210(3):121-125. Epub 2018 Dec 7.

Food Standards Australia New Zealand, Canberra, ACT.

Objective: To assess the median urine iodine concentration (UIC) of young adults in the Top End of Northern Territory, before and after fortification of bread with iodised salt became mandatory.

Design, Setting: Analysis of cross-sectional data from two longitudinal studies, the Aboriginal Birth Cohort and the non-Indigenous Top End Cohort, pre- (Indigenous participants: 2006-2007; non-Indigenous participants: 2007-2009) and post-fortification (2013-15).

Participants: Indigenous and non-Indigenous Australian young adults (mean age: pre-fortification, 17. Read More

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http://dx.doi.org/10.5694/mja2.12031DOI Listing
February 2019

Evidence for compromised data integrity in studies of liberal peri-operative inspired oxygen.

Anaesthesia 2019 Feb 17. Epub 2019 Feb 17.

Department of Anaesthesia and Pain Medicine, Royal Melbourne Hospital, Parkville, Vic., Australia.

In 2016 the World Health Organization recommended intra-operative ventilation with 80% inspired oxygen to reduce surgical site infection rates, based upon a meta-analysis of 15 randomised controlled trials, of which two were by Mario Schietroma's research group. Five trials by this group have been retracted for duplication, plagiarism, statistical error and lack of ethical approval. We analysed 40 papers by this group: 24 randomised controlled trials (5064 participants) and 16 observational studies (1847 patients). Read More

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http://dx.doi.org/10.1111/anae.14584DOI Listing
February 2019

Neuroendocrine Neoplasms Associated with Germline Pathogenic Variants in the Homologous Recombination Pathway.

Endocr Pathol 2019 Feb 16. Epub 2019 Feb 16.

Fred A. Litwin Family Center in Genetic Medicine, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s12022-019-9569-4DOI Listing
February 2019

Characterizing Perceptions Around the Patient-Oncologist Relationship: a Qualitative Focus Group Analysis.

J Cancer Educ 2019 Feb 16. Epub 2019 Feb 16.

Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

The purpose of the current study was to characterize the experiences of cancer patients and their caregiver/family members around their relationship with their oncologist, health care team, and the hospital environment. Participants were recruited from The Ohio State University Comprehensive Cancer Center. Participant sociodemographic factors were assessed. Read More

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http://dx.doi.org/10.1007/s13187-019-1481-6DOI Listing
February 2019

Evaluating the health risk of metals (Zn, Cr, Cd, Ni, Pb) in staple foods from Lagos and Ogun States, Southwestern Nigeria.

Environ Monit Assess 2019 Feb 16;191(3):167. Epub 2019 Feb 16.

Department of Pure and Applied Zoology, Federal University of Agriculture, Abeokuta, Ogun State, PMB 2240, Nigeria.

The study evaluated the health risk of metals in commonly consumed staple foods from Lagos and Ogun states, southwestern Nigeria. One hundred and thirty-three food samples were collected and analyzed for Zn, Cr, Cd, Ni, and Pb using atomic absorption spectrophotometric method. Data collected were analyzed for simple descriptive and inferential statistics using SPSS for Windows. Read More

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http://dx.doi.org/10.1007/s10661-019-7307-5DOI Listing
February 2019

Dynamic Piston Function of the Mitral Annulus to Assess Early Left Ventricular Diastolic Filling: A Proof of Concept Study.

Cardiol Ther 2019 Feb 16. Epub 2019 Feb 16.

Cardiovascular Medicine Division, University of Puerto Rico School of Medicine, San Juan, PR, USA.

Introduction: Early left ventricular (LV) filling has been described as an asymmetric toroidal vortex ring of blood entering the LV upon opening of the mitral valve. This phenomenon is in part responsible for cyclical changes in LV volumes during the cardiac cycle and also contributes to the apical and basal longitudinal displacements of the mitral annulus (MA). Although MA early diastolic (e') velocities have been used to assess early LV filling characteristics, accurate distinction between normal aging and pathological diastolic dysfunction (DD) might be challenging at times. Read More

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http://dx.doi.org/10.1007/s40119-019-0130-9DOI Listing
February 2019

The Clinical and Molecular Epidemiology of CTX-M-9 Group Producing Enterobacteriaceae Infections in Children.

Infect Dis Ther 2019 Feb 16. Epub 2019 Feb 16.

Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA.

Introduction: The pandemic of extended-spectrum beta-lactamase-(ESBL)-producing Enterobacteriaceae (Ent) is strongly linked to the dissemination of CTX-M-type-ESBL-Ent. We sought to define the epidemiology of infections in children due to an emerging resistance type, CTX-M-9-group-producing-Ent (CTX-M-9-grp-Ent).

Methods: A retrospective matched case-control analysis of children with CTX-M-9-grp-Ent infections who received medical care at three Chicago area hospitals was performed. Read More

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http://dx.doi.org/10.1007/s40121-019-0237-2DOI Listing
February 2019

miR-21 reverses impaired decidualization through modulation of KLF12 and NR4A1 expression in human endometrial stromal cells†.

Biol Reprod 2019 Feb 17. Epub 2019 Feb 17.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.

Impaired decidualization has been considered a major cause of infertility in adenomyosis. However, the mechanism remains poorly understood. Recent studies suggest that micro RNAs (miR) play a crucial role in embryo implantation. Read More

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http://dx.doi.org/10.1093/biolre/ioz026DOI Listing
February 2019

Breakthroughs and new horizons in reproductive biology of rare and endangered animal species.

Biol Reprod 2019 Feb 17. Epub 2019 Feb 17.

Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Sheffield S10 2SF, UK.

Because of higher extinction rates due to human and natural factors, more basic and applied research in reproductive biology is required to preserve wild species and design proper strategies leading to sustainable populations. The objective of the review is to highlight recent, inspiring breakthroughs in wildlife reproduction science that will set directions for future research and lead to more successes in conservation biology. Despite new tools and approaches allowing a better and faster understanding of key mechanisms, we still know little about reproduction in endangered species. Read More

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http://dx.doi.org/10.1093/biolre/ioz031DOI Listing
February 2019

Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial.

JAMA 2019 Feb 17. Epub 2019 Feb 17.

Departmento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago.

Importance: Abnormal peripheral perfusion after septic shock resuscitation has been associated with organ dysfunction and mortality. The potential role of the clinical assessment of peripheral perfusion as a target during resuscitation in early septic shock has not been established.

Objective: To determine if a peripheral perfusion-targeted resuscitation during early septic shock in adults is more effective than a lactate level-targeted resuscitation for reducing mortality. Read More

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http://dx.doi.org/10.1001/jama.2019.0071DOI Listing
February 2019

Circulating anthocyanin metabolites mediate vascular benefits of blueberries: insights from randomized controlled trials, metabolomics, and nutrigenomics.

J Gerontol A Biol Sci Med Sci 2019 Feb 16. Epub 2019 Feb 16.

Division of Cardiology, Pulmonology, and Vascular Medicine, University Duesseldorf, Germany.

Potential health benefits of blueberries may be due to vascular effects of anthocyanins which predominantly circulate in blood as phenolic acid metabolites. We investigated which role blueberry anthocyanins and circulating metabolites play in mediating improvements in vascular function and explore potential mechanisms using metabolomics and nutrigenomics. Purified anthocyanins exerted a dose-dependent improvement of endothelial function in healthy humans, as measured by flow-mediated dilation (FMD). Read More

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http://dx.doi.org/10.1093/gerona/glz047DOI Listing
February 2019

Untargeted Metabolomics and Inflammatory Markers Profiling in Children With Crohn's Disease and Ulcerative Colitis-A Preliminary Study.

Inflamm Bowel Dis 2019 Feb 17. Epub 2019 Feb 17.

Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland.

Background: Metabolic profiling might be used to identify disease biomarkers. The aim of our study was to determine the usefulness of untargeted metabolomics analysis to detect differences in serum metabolites between newly diagnosed and untreated pediatric patients with Crohn's disease (CD) or ulcerative colitis (UC) in comparison with a control group (Ctr). Moreover, we investigated the potential of profiling metabolomics and inflammatory markers to improve the noninvasive diagnosis of CD and UC in children. Read More

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http://dx.doi.org/10.1093/ibd/izy402DOI Listing
February 2019

Dual role of TGF-B in early pregnancy: Clues from tumor progression.

Biol Reprod 2019 Feb 17. Epub 2019 Feb 17.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

TGF-β signaling in the endometrium is active during the implantation period and has a pivotal role in regulating endometrial receptivity and embryo implantation. During embryo implantation, both apoptosis and proliferation of endometrial cells happen at the same time and it seems TGF-β is the factor that controls both of these processes. As shown in cancer cells, in special conditions this cytokine can have a dual effect and switch the action from apoptosis to proliferation. Read More

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http://dx.doi.org/10.1093/biolre/ioz024DOI Listing
February 2019

Immunogenicity characterization of genetically fused or chemically conjugated heat-stable toxin (STa) toxoids of enterotoxigenic Escherichia coli (ETEC) in mice and pigs.

FEMS Microbiol Lett 2019 Feb 17. Epub 2019 Feb 17.

Department of Diagnostic Medicine/Pathobiology, Kansas State University College of Veterinary Medicine, Manhattan, Kansas, USA.

Enterotoxigenic Escherichia coli (ETEC) producing type Ib heat-stable toxin (STa) are a top cause of children's diarrhea and travelers' diarrhea, thus STa needs to be targeted in ETEC vaccine development. However, since this 19-amino acid STa is poorly immunogenic, the effort to genetically fuse or chemically couple to carrier proteins has been made to enhance STa immunogenicity. In this study, we selected one genetic fusion and one chemical conjugate to comparatively evaluate STa immunogenicity. Read More

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http://dx.doi.org/10.1093/femsle/fnz037DOI Listing
February 2019

Sarcopenia and variation in the Human Leukocyte Antigen complex.

J Gerontol A Biol Sci Med Sci 2019 Feb 17. Epub 2019 Feb 17.

Epidemiology and Public Health Group, University of Exeter Medical School, RILD Building, Barrack Road, Exeter, UK.

Background: Aging is characterized by chronic inflammation plus muscle mass and strength loss, termed sarcopenia. Human Leukocyte Antigen (HLA) types are drivers of autoimmune disease, although with limited penetrance. We tested whether autoimmune diagnoses are associated with sarcopenia, and whether HLA types and related genetic variants associate with sarcopenia in autoimmune disease free older people. Read More

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http://dx.doi.org/10.1093/gerona/glz042DOI Listing
February 2019

Small Cell Lung Cancer with Pituitary Metastasis Presenting as Secondary Adrenal Insufficiency: A Case Report and Literature Review.

Am J Case Rep 2019 Feb 17;20:207-211. Epub 2019 Feb 17.

Department of Endocrinology, University of California San Francisco, San Francisco, CA, USA.

BACKGROUND Pituitary gland metastasis is rarely the initial presentation of metastatic cancer. Most cases of pituitary gland metastasis are asymptomatic with diabetes insipidus being the most common symptomatic presentation. It can rarely present with symptoms of hormone underproduction such as secondary adrenal insufficiency. Read More

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http://dx.doi.org/10.12659/AJCR.913388DOI Listing
February 2019

Ursolic Acid Exhibits Potent Anticancer Effects in Human Metastatic Melanoma Cancer Cells (SK-MEL-24) via Apoptosis Induction, Inhibition of Cell Migration and Invasion, Cell Cycle Arrest, and Inhibition of Mitogen-Activated Protein Kinase (MAPK)/ERK Signaling Pathway.

Med Sci Monit 2019 Feb 17;25:1283-1290. Epub 2019 Feb 17.

Department of Hand and Pediatric Surgery, The First Hospital of Jilin University, Changchun, Jilin, China (mainland).

BACKGROUND Ursolic acid is an important bioactive triterpenoid that has been reported to be of tremendous pharmacological importance. However, the anticancer potential of ursolic acid has not been examined against metastatic melanoma cells. Therefore, in this study we examined the anticancer potential of ursolic acid and its mode of action. Read More

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http://dx.doi.org/10.12659/MSM.913069DOI Listing
February 2019

Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties.

Endocr Connect 2019 Mar;8(3):R55-R70

Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany.

The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide, especially as a result of our aging society, high caloric intake and sedentary lifestyle. Besides the well-known complications of T2DM on the cardiovascular system, the eyes, kidneys and nerves, bone strength is also impaired in diabetic patients. Patients with T2DM have a 40-70% increased risk for fractures, despite having a normal to increased bone mineral density, suggesting that other factors besides bone quantity must account for increased bone fragility. Read More

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http://dx.doi.org/10.1530/EC-18-0456DOI Listing

The preanalytical phase - a field for improvement.

Diagnosis (Berl) 2019 Feb 18. Epub 2019 Feb 18.

Paracelsus Medical University, Department of Laboratory Medicine, Salzburg, Austria.

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http://dx.doi.org/10.1515/dx-2019-0002DOI Listing
February 2019

Novel use of tranexamic acid to reduce the need for Nasal Packing in Epistaxis (NoPac) randomised controlled trial: research protocol.

BMJ Open 2019 Feb 15;9(2):e026882. Epub 2019 Feb 15.

Research Design Service South West, Bristol, UK.

Introduction: Patients presenting to emergency departments (EDs) with epistaxis uncontrolled by subsequent simple first aid measures or application of topical vasoconstrictors will typically undergo anterior nasal packing. Packing is effective, but can be extremely painful and unpleasant and patients usually need hospital admission. Tranexamic acid (TXA) is a cheap, safe, readily available antifibrinolytic agent known to be beneficial in a variety of clinical settings where uncontrolled bleeding may be a problem. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026882DOI Listing
February 2019

Paramedics' experiences of administering fascia iliaca compartment block to patients in South Wales with suspected hip fracture at the scene of injury: results of focus groups.

BMJ Open 2019 Feb 15;9(2):e026073. Epub 2019 Feb 15.

Medical School, Swansea University, Swansea, UK.

Objectives: To explore paramedics' experience of delivering fascia iliaca compartment block FICB) to patients with suspected hip fracture at the scene of injury.

Design: Focus groups within a randomised controlled trial.

Setting: Paramedics based at ambulance stations in the catchment area of one Emergency Department in South Wales, recruited and trained in a feasibility study about an alternative to routine prehospital pain management for patients with suspected hip fracture. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026073DOI Listing
February 2019

Trends in resource use and effectiveness of ultrasound detection of fetal structural anomalies in France: a multiple registry-based study.

BMJ Open 2019 Feb 15;9(2):e025482. Epub 2019 Feb 15.

Fetal Medicine Department, Sorbonne University, AP-HP, Armand Trousseau Hospital, Paris, France.

Objective: To analyse trends in the number of ultrasound examinations in relation to the effectiveness of prenatal detection of birth defects using population-based data in France.

Design: A multiple registry-based study of time trends in resource use (number of ultrasounds) and effectiveness (proportion of cases prenatally diagnosed).

Setting: Three registries of congenital anomalies and claims data on ultrasounds for all pregnant women in France. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025482DOI Listing
February 2019

Frailty in the context of rehabilitation interventions for adults: protocol for a scoping review.

BMJ Open 2019 Feb 15;9(2):e024838. Epub 2019 Feb 15.

Toronto Rehabilitation Institute - University Health Network, Toronto, Ontario, Canada.

Introduction: Although a growing number of frail adults can benefit from rehabilitation services, few are included in rehabilitation services, and reasons for their exclusion are not well understood. To inform research directions in rehabilitation for all adults (aged 18 years and older), we will conduct a scoping review to describe (1) the characteristics of frail adult individuals included in rehabilitation interventions (eg, age range, inclusion and exclusion criteria that are applied), (2) the type of rehabilitation interventions that are used for individuals who are considered frail and (3) the commonly reported outcome measures used for these rehabilitation interventions.

Methods: This scoping review will be guided by Arksey and O'Malley's methodological framework. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024838DOI Listing
February 2019

Burden of non-accidental mortality attributable to ambient temperatures: a time series study in a high plateau area of southwest China.

BMJ Open 2019 Feb 15;9(2):e024708. Epub 2019 Feb 15.

Department of Preventive Medicine, Shantou University Medical College, Shantou, China.

Objective: To examine the total non-accidental mortality burden attributable to ambient temperatures and assess the effect modification of the burden by specific causes of death and individual characteristics in a high plateau area in southwest China.

Methods: Using daily mortality and meteorological data from 2009 to 2016, we applied a quasi-Poisson model combined with a distributed lag non-linear model to estimate the temperature-mortality association with the assessment of attributable fraction and number. We calculated attributable fractions and deaths with 95% empirical CIs (eCIs), that were due to cold and heat, defined as temperatures below and above the median temperature, and for mild and extreme temperatures, defined by cut-offs at the 2. Read More

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February 2019

Quality of reporting of outcomes in trials of therapeutic interventions for pressure ulcers in adults: a protocol for a systematic survey.

BMJ Open 2019 Feb 15;9(2):e024633. Epub 2019 Feb 15.

Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada.

Pressure ulcers (PUs) have a high incidence, especially in hospital units. Randomised clinical trials (RCTs) of therapeutic interventions for PU should include a clear description of the outcomes and results to enhance transparency and replicability.

Objectives: The primary objective of this study is to assess the completeness of the descriptions of the outcomes of therapeutic interventions in RCTs in adult patients with PU. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024633DOI Listing
February 2019

Trial summary and protocol for a phase II randomised placebo-controlled double-blinded trial of Interleukin 1 blockade in Acute Severe Colitis: the IASO trial.

BMJ Open 2019 Feb 15;9(2):e023765. Epub 2019 Feb 15.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, UK.

Introduction: Acute severe ulcerative colitis (ASUC) is a severe manifestation of ulcerative colitis (UC) that warrants hospitalisation. Despite significant advances in therapeutic options for UC and in the medical management of steroid-refractory ASUC, the initial treatment paradigm has not changed since 1955 and is based on the use of intravenous corticosteroids. This treatment is successful in approximately 50% of patients but failure of this and subsequent medical therapy still occurs, with colectomy rates of up to 40% reported. Read More

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February 2019
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