5,207,784 results match your criteria Medicine & Health Rhode Island [Journal]

  • Page 1 of 104156

A clinical multi-center registry study on digital nerve repair using a biodegradable nerve conduit of PGA with external and internal collagen scaffolding.

Microsurgery 2018 Dec 18. Epub 2018 Dec 18.

Faculty of Medicine, Department of Plastic and Reconstructive Surgery, Kindai University, Osakasayama, Japan.

Background: In this study, we evaluated the clinical efficacy of a biodegradable nerve conduit constructed of polyglycolic acid (PGA) tube with external and internal collagen scaffolding for digital nerve repair.

Patients And Methods: A multi-center registry study was conducted in 11 locations between July 2013 and May 2016. Multiple mechanisms of injury included clean-cut (12 patients), crush (5 patients), and avulsion (3 patients) types of injuries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/micr.30417DOI Listing
December 2018

Treatment consensus for management of polymyositis and dermatomyositis among rheumatologists, neurologists and dermatologists.

J Dermatol 2018 Dec 18. Epub 2018 Dec 18.

Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.

Although rheumatologists, neurologists and dermatologists see patients with polymyositis (PM) and dermatomyositis (DM), their management appears to vary depending on the physician's specialty. The aim of the present study was to establish the treatment consensus among specialists of the three fields to standardize the patient care. We formed a research team supported by a grant from the Ministry of Health, Labor and Welfare, Japan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.14604DOI Listing
December 2018

Optimal surgical treatment in patients with T1b gallbladder cancer: An international multicenter study.

J Hepatobiliary Pancreat Sci 2018 Dec;25(12):533-543

Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.

Background: There is no consensus on the optimal treatment of T1b gallbladder cancer (GBC) due to the lack of evidence and the difficulty of anatomy and pathological standardization.

Methods: A total of 272 patients with T1b GBC who underwent surgical resection at 14 centers with specialized hepatobiliary-pancreatic surgeons and pathologists in Korea, Japan, Chile, and the United States were studied. Clinical outcomes including disease-specific survival (DSS) rates according to the types of surgery were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jhbp.593DOI Listing
December 2018

Intra-articular Corticosteroids for Knee Pain-What Have We Learned from the Equine Athlete and Current Best Practice.

J Knee Surg 2018 Dec 18. Epub 2018 Dec 18.

Department of Orthopaedic Surgery, Division of Sports Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

The use of intra-articular corticosteroids for traumatic arthritis and osteoarthritis (OA) is common in the horse. The beneficial and deleterious effects of the principal corticosteroids used betamethasone esters (Celestone [Soluspan], methylprednisolone acetate [Depo Medrol], and triamcinolone acetonide [TA] [Vetalog or Kenalog]) have been defined for the horse. While TA has both disease-modifying as well as symptom-modifying effects, methyl prednisolone acetate has deleterious effects on the articular cartilage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1676449DOI Listing
December 2018

Rabbit Model of Extending Knee Joint Contracture: Progression of Joint Motion Restriction and Subsequent Joint Capsule Changes after Immobilization.

J Knee Surg 2018 Dec 18. Epub 2018 Dec 18.

Department of Orthopedics, The Second Hospital of Anhui Medical University, Hefei, People's Republic of China.

This study aimed to develop a rabbit model of knee contracture in extension and investigate the natural history of motion loss and time-dependent changes in the joint capsule after immobilization. We immobilized the unilateral knee joints of 32 rabbits by maintaining the knee joint in a plaster cast at full extension. Eight rabbits were euthanized at 2, 4, 6, and 8 weeks after casting, respectively, and the lower extremities were disarticulated at the hip joint. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1676502DOI Listing
December 2018

Is There a Difference between Cemented and Uncemented Femoral Stem Extensions in Revision Knee Arthroplasty?

J Knee Surg 2018 Dec 18. Epub 2018 Dec 18.

Chapel Hill Orthopedics Surgery and Sports Medicine, Chapel Hill, North Carolina.

A stem is usually recommended for the femoral component in revision total knee arthroplasty (TKA) for reasons of alignment, fixation, and bone loss. However, the optimal method of fixation for the femoral component stem remains controversial. We queried the prospective revision TKA database of one surgeon and performed a clinical and radiographic evaluation of 84 knee revisions in which a femoral component stem extension was implanted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1676567DOI Listing
December 2018

Osteochondral Allograft Transplantation: Identifying the Biomechanical Impact of Using Shorter Grafts and Pulsatile Lavage on Graft Stability.

J Knee Surg 2018 Dec 18. Epub 2018 Dec 18.

Division of Sports Medicine, Department of Orthopaedic Surgery, Warren Alpert Medical School, Brown University, Providence, Rhode Island.

This study seeks to identify the ability of shorter osteochondral allografts (OCAs) to resist displacement/failure. Additionally, this study seeks to evaluate the effect of pulsatile lavage (PL) on the biomechanical stability of the OCA. Fifteen-millimeter diameter, human cadaveric, OCAs of 4, 7, and 10 mm in depth were harvested for comparison of resistance to compressive and tensile loads. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1676501DOI Listing
December 2018

Depression and Diabetic Peripheral Neuropathy: Birds of a Feather, But When do They Flock Together?

Exp Clin Endocrinol Diabetes 2018 Dec 18. Epub 2018 Dec 18.

Diabetes Centre-Diabetic Foot Clinic, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece.

The association between diabetes and depression is well recognised. Similarly, diabetic peripheral neuropathy (DPN) is a frequent complication of diabetes. Given the high prevalence of these conditions individually, it is hardly surprising they frequently interact, conferring additional morbidity and a higher mortality risk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0808-4269DOI Listing
December 2018

Higher Serum Uric Acid is a Risk Factor of Vertebral Fractures in Postmenopausal Women with Type 2 Diabetes Mellitus.

Exp Clin Endocrinol Diabetes 2018 Dec 18. Epub 2018 Dec 18.

Department of Internal Medicine 1, Shimane University Faculty of Medicine, Japan.

Purpose: Serum uric acid (UA) level may affect bone metabolism because it has an anti-oxidative effect. However, whether serum UA level is associated with a fracture risk in type 2 diabetes mellitus (T2DM) is unclear. We thus aimed to clarify the association between serum UA and bone parameters in T2DM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0815-4954DOI Listing
December 2018

An Update on Addison's Disease.

Exp Clin Endocrinol Diabetes 2018 Dec 18. Epub 2018 Dec 18.

Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany.

Addison's disease - the traditional term for primary adrenal insufficiency (PAI) - is defined as the clinical manifestation of chronic glucocorticoid- and/or mineralocorticoid deficiency due to failure of the adrenal cortex which may result in an adrenal crisis with potentially life-threatening consequences. Even though efficient and safe pharmaceutical preparations for the substitution of endogenous gluco- and mineralocorticoids are established in therapy, the mortality in patients with PAI is still increased and the health-related quality of life (HRQoL) is often reduced.PAI is a rare disease but recent data report an increasing prevalence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0804-2715DOI Listing
December 2018

[Life of a Century: Gottfried Bermann Fischer (1897-1995) - Surgeon and Publisher].

Authors:
Florian Bruns

Dtsch Med Wochenschr 2018 Dec 18;143(25):1866-1870. Epub 2018 Dec 18.

Gottfried Bermann Fischer was a German-Jewish physician and publisher who dedicated his life to the S. Fischer publishing company which ranks among the most significant German-language publishers in the 20th century. In 1925 Bermann left his position as a surgeon and married Brigitte Fischer, daughter of the company's founder Samuel Fischer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0630-4437DOI Listing
December 2018

[Searching the Roots of Erb's Auscultation Point].

Dtsch Med Wochenschr 2018 Dec 18;143(25):1852-1857. Epub 2018 Dec 18.

"Erb's point" is the fifth point of auscultation for the heart exam, located in the third intercostal space close to the sternum. It has sometimes been attributed to famous German neurologist Wilhelm Heinrich Erb (1840 - 1921), but without historical evidence. Erb's focus on neurology suggested that the auscultation point may have been confused with other points in the neck named after Erb. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0596-4733DOI Listing
December 2018

[Santiago Ramón y Cajal - Neuroanatomist, Artist and Writer].

Dtsch Med Wochenschr 2018 Dec 18;143(25):1847-1851. Epub 2018 Dec 18.

Santiago Ramón y Cajal came from North Spain and was very talented in painting and writing. Actually he wanted to become a painter but his father, who was a medical doctor himself, forced him to study medicine. In the end, he became a famous neuroanatomist, developed the neuron theory and, together with Camillo Golgi, was awarded the Nobel Price for medicine in 1906. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0640-4652DOI Listing
December 2018

[Shostakovich's Opera "The Nose" and its Connection to Medicine].

Authors:
Martin Middeke

Dtsch Med Wochenschr 2018 Dec 18;143(25):1832-1836. Epub 2018 Dec 18.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0708-6250DOI Listing
December 2018

Correction: Congenital Transcobalamin II Deficiency: A Rare Entity with a Broad Differential.

Klin Padiatr 2017 Nov 18;229(6):e1. Epub 2018 Dec 18.

Pediatric Hematology Oncology, Hannover Medical School, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0820-5131DOI Listing
November 2017

Worldwide research productivity in nuclear medicine literature.

Nuklearmedizin 2018 Dec 18;57(6):234-241. Epub 2018 Dec 18.

Aim: This study aimed to assess the quantity and quality of papers published in subspecialty nuclear medicine journals and provide an overview of worldwide research activity carried out in the field of nuclear medicine.

Methods: Papers published in subspecialty nuclear medicine journals between 2008 and 2017 were retrieved from the Web of Science. The number of papers and citations were used to evaluate the quantity and quality of the articles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3413/Nukmed-0995-18-08DOI Listing
December 2018

Fine-needle aspiration biopsies of thyroid nodules.

Nuklearmedizin 2018 Dec 18;57(6):211-215. Epub 2018 Dec 18.

Objective: The purpose of the study was the characterization of adverse events (AEs) after fine-needle aspiration biopsies (FNABs) of thyroid nodules, as well as possible predisposing factors.

Methods: A total of 205 patients, each of whom had undergone an FNAB of a thyroid nodule, were included in the study (15 of whom were taking anticoagulant medication). The thyroid nodules were classified according to the ultrasound criteria of the American Thyroid Association (ATA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3413/Nukmed-0981-18-06DOI Listing
December 2018

Artifacts in 3D Prenatal Sonography.

Ultraschall Med 2018 Dec 18. Epub 2018 Dec 18.

Center for Ultrasound and Prenatal Medicine, Frankfurt a/M, Germany.

Purpose:  Artifacts may be part of any 3D sonographic examination during pregnancy and can disturb a routine diagnostic procedure, even simulate fetal malformation. The aim of this study was to classify the artifacts in different types according to their appearance.

Materials And Methods:  A total of 2349 healthy fetuses examined during the last five years was included in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0790-8163DOI Listing
December 2018

[Clinical analysis of candidemia in immunocompetent patients].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1063-1069

Department of Nosocomial Infection,Peking University Third Hospital, Beijing 100191, China.

Objective: To investigate the etiological and clinical characteristics of immunocompetent patients with candidemia.

Methods: The clinical and microbiological data of patients diagnosed as candidemia admitted in Peking University Third Hospital from January 2010 to June 2016 were retrospectively analyzed. Underlying diseases, Candida spp. Read More

View Article

Download full-text PDF

Source
December 2018

[Analysis of risk factors for acute lung injury/acute respiratory distress syndrome after esophagectomy].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1057-1062

Department of Critical Care Medicine, Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing 100142, China.

Objective: To explore the incidence and risk factors for the acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) after resection of esophageal carcinoma.

Methods: We retrospectively analyzed 422 consecutive patients admitted to the Department of Critical Care Medicine with esophageal carcinoma undergoing esophagectomy from January 2010 to December 2016 in Peking University Cancer Hospital. ALI/ARDS were diagnosed, the patients were divided into ALI/ARDS group and control group without ALI/ARDS, the differences of clinical features were contrasted between the two groups, and the multivariate Logistic regression modeling was used to identify the independent risk factors for ALI/ARDS. Read More

View Article

Download full-text PDF

Source
December 2018

[A multi-center cross-sectional survey of medicine application in patients with osteoarthritis in China].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1044-1048

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China.

Objective: To investigate the clinical characteristics, the medicine application and to evaluate the disease activity in patients with osteoarthritis (OA) in China.

Methods: This was a cross-sectional study. Totally 1 066 cases of OA from 40 hospitals in China from April to October 2017 were retrospectively enrolled. Read More

View Article

Download full-text PDF

Source
December 2018

[Case series and clinical analysis of 14 cases of catastrophic antiphospholipid syndrome].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1033-1038

Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.

Objective: Catastrophic antiphospholipid syndrome (CAPS), also known as Asherson's syndrome, is a special subtype of antiphospholipid syndrome (APS) characterized by multiple intravascular thrombosis involving multiple organs systems or tissues simultaneously or continuously, high titer antiphospholipid antibodies and high mortality rate. This article's aims was to analyze the clinical manifestation, laboratory examination and treatment therapy of CAPS for the purpose of improving the understanding, diagnosis and treatment of the disease in clinical practice.

Methods: Retrospective analysis and descriptive statistics were applied to the clinical manifestations and laboratory findings of 14 CAPS cases from APS Shanghai Database (APS-SH) with catastrophic antiphospholipid. Read More

View Article

Download full-text PDF

Source
December 2018

[Multidisciplinary classification of magnetic resonance imaging features of neuropsychiatric lupus].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1009-1013

Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China.

Objective: To investigate the clinical correlation between the manifestations of neuropsychiatric lupus (NPSLE) and brain magnetic resonance imaging (MRI).

Methods: Retrospective analysis of 65 neuropsychiatric lupus patients with brain MRI and clinical data from Peking University Third Hospital from January 2006 to October 2016, which was classified by rheumatologist, neurologists, and radiologists based on their brain MRI findings. The correlation between brain MRI findings and clinical manifestations was analyzed. Read More

View Article

Download full-text PDF

Source
December 2018

Garcinia Multiflora Inhibits FPR1-Mediated Neutrophil Activation and Protects Against Acute Lung Injury.

Cell Physiol Biochem 2018 Dec 12;51(6):2776-2793. Epub 2018 Dec 12.

Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan,

Background/aims: Formyl peptide receptors (FPRs) recognize different endogenous and exogenous molecular stimuli and mediate neutrophil activation. Dysregulation of excessive neutrophil activation and the resulting immune responses can induce acute lung injury (ALI) in the host. Accordingly, one promising approach to the treatment of neutrophil-dominated inflammatory diseases involves therapeutic FPR1 inhibition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495970DOI Listing
December 2018

ATM-Mediated Phosphorylation of Cortactin Involved in Actin Polymerization Promotes Breast Cancer Cells Migration and Invasion.

Cell Physiol Biochem 2018 Dec 14;51(6):2972-2988. Epub 2018 Dec 14.

Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education, Chongqing Medical University, Chongqing,

Background/aims: The ataxia-telangiectasia mutated (ATM) protein kinase is critical for the maintenance of genomic stability and acts as tumor suppressor. Although evidence shows that a DNA damage-independent ATM (oxidized ATM) may be involved in cancer progression, the underlying mechanism is still unclear.

Methods: Immunohistochemistry, immunofluorescence and western blotting were applied to detect the levels of oxidized ATM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496048DOI Listing
December 2018

Loss of Tumor Suppressor Gene Function in Human Cancer: An Overview.

Cell Physiol Biochem 2018 Dec 12;51(6):2647-2693. Epub 2018 Dec 12.

Research Institute of Pharmaceutical Science, Department of Pharmacy, Seoul National University College of Pharmacy, Seoul, Republic of

Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research has been conducted over the last few decades to elucidate the role of TSGs in cancer development. In cancer, loss of TSG function occurs via the deletion or inactivation of two alleles, according to Knudson's two-hit model hypothesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495956DOI Listing
December 2018

FOXD1 Promotes Cell Growth and Metastasis by Activation of Vimentin in NSCLC.

Cell Physiol Biochem 2018 Dec 12;51(6):2716-2731. Epub 2018 Dec 12.

Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Background/aims: Forkhead box D1 (FOXD1) has a well-established role in early embryonic development and organogenesis and functions as an oncogene in several cancers. However, the clinical significance and biological roles of FOXD1 in non-small cell lung cancer (NSCLC) remain largely unknown.

Methods: A total of 264 primary NSCLC tissue samples were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495962DOI Listing
December 2018

Effects of Ca2+-Activated Cl- Channel ANO1inhibitors on Pacemaker Activity in Interstitial Cells of Cajal.

Cell Physiol Biochem 2018 Dec 14;51(6):2887-2899. Epub 2018 Dec 14.

Department of Physiology, College of Medicine, Chosun University, Gwangju, Republic of

Background/aims: Anoctamin1 (Ca2+-activated Cl- channel, ANO1) is a specific marker of the interstitial cells of Cajal (ICC) in the gastrointestinal tract, and are candidate proteins that can function as pacemaker channels. Recently, novel selective ANO1 inhibitors were discovered and used to study Ca2+-activated Cl- channels. Therefore, to investigate whether ANO1 channels function as pacemaker channels, selective ANO1 inhibitors were tested with respect to the pacemaker potentials in ICC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496041DOI Listing
December 2018

Artemisinin Ameliorates Osteoarthritis by Inhibiting the Wnt/β-Catenin Signaling Pathway.

Cell Physiol Biochem 2018 Dec 11;51(6):2575-2590. Epub 2018 Dec 11.

Department of Orthopaedics Trauma and Hand Surgery & Guangxi Key Laboratory of Regenerative Medicine, International Joint Laboratory on Regeneration of Bone and Soft Tissue, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Background/aims: Current drug therapies for osteoarthritis (OA) are not practical because of the cytotoxicity and severe side-effects associated with most of them. Artemisinin (ART), an antimalarial agent, is well known for its safety and selectivity to kill injured cells. Based on its anti-inflammatory activity and role in the inhibition of OA-associated Wnt/β-catenin signaling pathway, which is crucial in the pathogenesis of OA, we hypothesized that ART might have an effect on OA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495926DOI Listing
December 2018

lncRNA MEG3 Suppresses the Tumorigenesis of Hemangioma by Sponging miR-494 and Regulating PTEN/ PI3K/AKT Pathway.

Cell Physiol Biochem 2018 Dec 14;51(6):2872-2886. Epub 2018 Dec 14.

Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai,

Background/aims: Dysregulation of long noncoding RNAs (lncRNAs) is associated with the proliferation and metastasis in a variety of cancers, of which lncRNA maternally expressed gene 3 (MEG3) has been indicated as a tumor suppressor in multiple malignancies. However, the underlying mechanisms by which MEG3 contributes to human hemangiomas (HAs) remain undetermined.

Methods: qRT-PCR analysis was performed to examine the expression levels of MEG3 and VEGF in proliferating or involuting phase HAs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496040DOI Listing
December 2018

Expression of PRDX6 Correlates with Migration and Invasiveness of Colorectal Cancer Cells.

Cell Physiol Biochem 2018 Dec 11;51(6):2616-2630. Epub 2018 Dec 11.

Institute of Nursing and Department of Nursing, Chang Gung Institute of Technology Chiayi Campus, Chiayi, Taiwan.

Background/aims: Colorectal cancer (CRC) is the third most common type of cancer and the second leading cause of cancer-related deaths worldwide. PRDXs are antioxidant enzymes that play an important role in cell differentiation, proliferation and apoptosis and have diverse functions in malignancy development. However, the mechanism of aberrant overexpression of PRDX6 in CRC remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495934DOI Listing
December 2018

Antidermatophyte Activity of the Gentiopicroside-Rich n-Butanol Fraction from Gentiana siphonantha Maxim. Root on a Guinea Pig Model of Dermatophytosis.

Complement Med Res 2018 Dec 15. Epub 2018 Dec 15.

Background: Gentiana siphonantha Maxim. is a traditional medicine for the treatment of rheumarthritis, icterepatitis, pain and hypertension; it is rich in gentiopicroside with anti-inflammatory, antibacterial, and free radical-scavenging activities. This study was to evaluate the antidermatophyte activity of G. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000492384DOI Listing
December 2018

The Prognostic Significance of NEK2 in Hepatocellular Carcinoma: Evidence from a Meta-Analysis and Retrospective Cohort Study.

Cell Physiol Biochem 2018 Dec 12;51(6):2746-2759. Epub 2018 Dec 12.

Department of Hepatic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou,

Background/aims: Numerous studies have shown that NIMA-related kinase 2 (NEK2) expression in hepatocellular carcinoma (HCC) tissue is associated with survival and clinicopathological features; however, the evidence remains inconclusive. Thus, we aimed to further explore the prognostic and clinicopathological significance of NEK2 expression in HCC using a two-part study consisting of a retrospective cohort study and a meta-analysis.

Methods: In the cohort study, NEK2 expression in 206 HCC samples and adjacent normal liver tissues was detected by immunohistochemistry (IHC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495966DOI Listing
December 2018

miR-486-3p Influences the Neurotoxicity of a-Synuclein by Targeting the SIRT2 Gene and the Polymorphisms at Target Sites Contributing to Parkinson's Disease.

Cell Physiol Biochem 2018 Dec 12;51(6):2732-2745. Epub 2018 Dec 12.

Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Guangdong,

Background/aims: Increasing evidence suggests the important role of sirtuin 2 (SIRT2) in the pathology of Parkinson's disease (PD). However, the association between potential functional polymorphisms in the SIRT2 gene and PD still needs to be identified. Exploring the molecular mechanism underlying this potential association could also provide novel insights into the pathogenesis of this disorder. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000495963DOI Listing
December 2018
1 Read

UV-light mediated green synthesis of silver and gold nanoparticles using Cornelian cherry fruit extract and their comparative effects in experimental inflammation.

J Photochem Photobiol B 2018 Dec 11;191:26-37. Epub 2018 Dec 11.

Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, 11 Arany Janos Street, 400028 Cluj-Napoca, Romania. Electronic address:

The purpose of our study is to investigate the comparative effects of materials based on silver and gold nanoparticles functionalized with polyphenols from Cornus Mas extract (AgNPs-CM and AuNPs-CM) in vivo on experimental inflammation. The nanoparticles were obtained at room temperature under UV irradiation and were characterized by different methods: ultraviolet-visible spectroscopy, transmission electron microscopy, X ray diffraction, Fourier transform infrared spectroscopy and dynamic light scattering. The modulatory effects of AgNPs-CM and AuNPs-CM on inflammation were quantified by oxidative stress parameters, pro and anti-inflammatory cytokines levels and apoptosis assessment at 2 h, 24 and 48 h after induction of inflammation with carrageenan in the paw tissue of Wistar rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jphotobiol.2018.12.006DOI Listing
December 2018

Photodegradable coumarin-derived amphiphilic dendrons for DNA binding: Self-assembly and phototriggered disassembly in water and air-water interface.

Colloids Surf B Biointerfaces 2018 Dec 11;175:428-435. Epub 2018 Dec 11.

Department of Medical Applied Chemistry, Chung Shan Medical University, Taichung City, Taiwan; Department of Medical Education, Chung Shan Medical University Hospital, Taichung City, Taiwan. Electronic address:

In this article, we demonstrate the self-assembly and photoresponive behavior of a novel coumarin-based amphiphilic dendron in both aqueous solution and air-water interface. The dendritic structure, namely C-IG, was composed of a lipophilic cholesterol and hydrophilic poly(amido amine) (PAMAM) dendron, and the amphiphilic counterpart is interconnected by a photolabile coumarin carbonate ester, enabling the photoinduced degradation of the amphiphiles in protic solvents via S1-like mechanism. A Nile red solubilization fluorescence assay suggests a low critical aggregation concentration for the micelle formation of C-IG in aqueous solutions (3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.colsurfb.2018.12.018DOI Listing
December 2018

Immobilization of type I collagen/hyaluronic acid multilayer coating on enoxacin loaded titania nanotubes for improved osteogenesis and osseointegration in ovariectomized rats.

Colloids Surf B Biointerfaces 2018 Dec 13;175:409-420. Epub 2018 Dec 13.

Department of Bone and Joint Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, PR China. Electronic address:

Titania nanotubes (Ti-NTs) have been proven to be good drug carriers and can release drugs efficiently around implants. Enoxacin (EN) is a broad-spectrum antibiotic that has the ability of anti-osteoclastogenesis. Immobilization of extracellular matrix components on the surface of the material can greatly enhance the biological activity of the implant and slow down the release rate of the drug in Ti-NTs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.colsurfb.2018.12.033DOI Listing
December 2018

Reply to Dr. Hamilton: Multi-level erector spinae plane block.

J Clin Anesth 2018 Dec 15;54:168. Epub 2018 Dec 15.

Kutahya Health Sciences University Hospital, Department of Anesthesiology and Pain Medicine, Kutahya, Turkey. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jclinane.2018.12.010DOI Listing
December 2018

Long-term survival in patients with advanced non-small-cell lung cancer treated with atezolizumab versus docetaxel: Results from the randomised phase III OAK study.

Eur J Cancer 2018 Dec 15;107:124-132. Epub 2018 Dec 15.

Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Background: Atezolizumab (anti-programmed death-ligand 1 [PD-L1]) received approval from the US Food and Drug Administration and European Medicines Agency for previously treated advanced non-small-cell lung cancer based on OAK-a randomised, phase III trial that showed significantly improved survival with atezolizumab versus docetaxel regardless of PD-L1 expression. With longer follow-up, we summarised the characteristics of long-term survivors (LTSs).

Methods: In OAK (NCT02008227), patients were randomised 1:1 to receive atezolizumab or docetaxel until loss of clinical benefit or disease progression, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2018.11.020DOI Listing
December 2018

Relationships between the bioavailability of polybrominated diphenyl ethers in soils measured with female C57BL/6 mice and the bioaccessibility determined using five in vitro methods.

Environ Int 2018 Dec 15;123:337-344. Epub 2018 Dec 15.

Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, Guangdong, PR China. Electronic address:

Several in vitro methods for simulating human gastrointestinal digestion have been validated for predicting the bioavailability of heavy metals, but the methods for successfully predicting the bioavailability of organic pollutants are still limited. In this study, we used an adapted fasting in vitro digestion method (Fa-VDM) from the Simulator of the Human Intestinal Microbial Ecosystem and four other in vitro methods comprising In Vitro Gastrointestinal, a physiologically-based extraction test, the unified BARGE method, and Deutsches Institut für Normung e.V. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envint.2018.12.022DOI Listing
December 2018

Technical considerations in lateral extra-articular reconstruction coupled with anterior cruciate ligament reconstruction: A simulation study evaluating the influence of surgical parameters on control of knee stability.

Clin Biomech (Bristol, Avon) 2018 Dec 11;61:136-143. Epub 2018 Dec 11.

Centre Orthopédique Santy-Group Ramsay-Générale de Santé - Hôpital privé Jean Mermoz, Lyon, France.

Background: Surgical parameters such as the selection of tibial and femoral attachment site, graft tension, and knee flexion angle at the time of fixation may influence the control of knee stability after lateral extra-articular reconstruction. This study aimed to determine how sensitive is the control of knee rotation and translation, during simulated pivot-shift scenarios, to these four surgery settings.

Methods: A computer model was used to simulate 625 lateral extra-articular reconstructions based upon five different variations of each of the following parameters: femoral and tibial attachment sites, knee flexion angle and graft tension at the time of fixation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinbiomech.2018.12.011DOI Listing
December 2018

Effects of Platycodin D on S100A8/A9-induced inflammatory response in murine mammary carcinoma 4T1 cells.

Int Immunopharmacol 2018 Dec 15;67:239-247. Epub 2018 Dec 15.

Institute of Chinese Traditional Surgery, LongHua Hospital Shanghai University of Traditional Chinese Medicine, 725 Wanpingnan Road, Shanghai 200032, China; Department of Breast Surgery, LongHua Hospital Shanghai University of Traditional Chinese Medicine, 725 Wanpingnan Road, Shanghai 200032, China. Electronic address:

Activation of the inflammatory signaling pathway is the most vital part of the pre-metastatic events of breast cancer. Platycodin D (PlaD) shows favorable pharmacological activities in anti-inflammatory and anti-tumor effect. The main purpose of this study was to survey the effects of PlaD on S100A8/A9-induced inflammation in mouse mammary carcinoma 4T1 cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2018.12.008DOI Listing
December 2018

Effects of AT-RvD1 on paraquat-induced acute renal injury in mice.

Int Immunopharmacol 2018 Dec 15;67:231-238. Epub 2018 Dec 15.

Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China. Electronic address:

Objective: To investigate the effects of aspirin-triggered resolvin D1 (AT-RvD1) on paraquat-induced acute renal injury (ARI) in mice.

Methods: The ARI mouse model was established by administering 28 mg/kg paraquat to C57BL/6J mice by intraperitoneal injection. The mice received 10 or 100 ng AT-RvD1 by intravenous injection in the tail vein 2 h after toxication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2018.12.029DOI Listing
December 2018

Semaphoring 4D is required for the induction of antioxidant stress and anti-inflammatory effects of dihydromyricetin in colon cancer.

Int Immunopharmacol 2018 Dec 15;67:220-230. Epub 2018 Dec 15.

Department of Oncology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China. Electronic address:

Semaphorin 4D (Sema4D) has been involved in cancer progression, the expression of which is associated with the poor clinical outcomes of some cancer patients. Dihydromyricetin (DMY) has antitumor potentials for different types of human cancer cells. However, the pharmacological effects of DMY on colon cancer (CC) or the regulatory effects of Sema4D on this process remain largely unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2018.12.025DOI Listing
December 2018

Advantage of Next-Generation Sequencing in Dynamic Monitoring of Circulating Tumor DNA over Droplet Digital PCR in Cetuximab Treated Colorectal Cancer Patients.

Transl Oncol 2018 Dec 15;12(3):426-431. Epub 2018 Dec 15.

Department of Medical Oncology, Fudan University Shanghai Cancer Center,Shanghai,China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:

Epidermal growth factor receptor (EGFR) blockade resistance is common in the treatment of RAS wide type colorectal cancer (CRC). During the treatment of cetuximab, acquired resistant genomic alterations always occurs earlier than disease progression observed by medical images. Identification of genomic alterations dynamically might have certain clinical significance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tranon.2018.11.015DOI Listing
December 2018

Association of generalized anxiety symptoms and panic with health care costs in older age-Results from the ESTHER cohort study.

J Affect Disord 2018 Nov 13;245:978-986. Epub 2018 Nov 13.

Department of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg 20246, Germany.

Background: Little is known specifically about the association between generalized anxiety symptoms or panic and health care costs in older age. The aim of this study was to examine the association between generalized anxiety symptoms, panic and health care costs in people aged 65 and over.

Methods: Cross-sectional data from the 8-year follow-up of a large, prospective cohort study, the ESTHER study, was used. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jad.2018.11.087DOI Listing
November 2018

Addressing the nexus of risk: Biobehavioral outcomes from a cluster randomized trial of the Women's Health CoOp Plus in Pretoria, South Africa.

Drug Alcohol Depend 2018 Dec 3;195:16-26. Epub 2018 Dec 3.

Research Computing Division, RTI International, 3040 E. Cornwallis Road, Research Triangle Park, NC, USA.

Background: HIV prevalence has increased among South African women who use alcohol and other drugs (AOD). However, HIV prevention and treatment efforts have not focused on this population. This study presents the efficacy of the Women's Health CoOp Plus (WHC+) in a cluster-randomized trial to reduce AOD use, gender-based violence, and sexual risk and to increase linkage to HIV care among women who use AODs, compared with HIV counseling and testing alone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drugalcdep.2018.10.036DOI Listing
December 2018

Endometrium cytokine profiles are altered following ovarian stimulation but almost not in subsequent hormone replacement cycles.

Cytokine 2018 Dec 15;114:6-10. Epub 2018 Dec 15.

Reproductive Medicine Center of Ruijin Hospital Affilited to Medical School of Shanghai Jiaotong University, Shanghai, China.

Purpose: To investigate the impact of ovarian stimulation and hormone replacement treatment on key regulatory cytokines in endometrial secretion during endometrium implantation window.

Methods: Fifty-six patients undergoing ovarian stimulation (OS) with gonadotropin releasing hormone antagonist and frozen embryo transfer with hormone replacement treatment (HRT) were recruited. Endometrial secretion aspiration was performed repeatedly during implantation window in natural, OS and HRT cycles of every patient. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cyto.2018.11.002DOI Listing
December 2018

Coupling the dynamics of diffused gases and microbial growth in modified atmosphere packaging.

Int J Food Microbiol 2018 Dec 8;292:31-38. Epub 2018 Dec 8.

Faculty of Health Sciences, Department of Food Sciences and Nutrition, University of Malta, Msida MSD 2080, Malta; Centre of Molecular Medicine and Biobanking, University of Malta, Msida MSD 2080, Malta. Electronic address:

Coupling microbial dynamics with the complete dynamics of the packaging gases is still a challenge. In this work the microbial growth kinetic parameters for Pseudomonas and Lactic Acid Bacteria (LAB) in MAP are identified based on accurate estimation of diffusivity of gases and parameter scaled sensitivity approaches. The microbial dynamics are also compared with those estimated based on partial pressure measurement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijfoodmicro.2018.11.027DOI Listing
December 2018
  • Page 1 of 104156