5,357,613 results match your criteria Medicine & Health Rhode Island [Journal]

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Eating behaviour and oxytocin in patients with childhood-onset craniopharyngioma and different grades of hypothalamic involvement.

Pediatr Obes 2019 Apr 23:e12527. Epub 2019 Apr 23.

Department of Pediatrics and Pediatric Hematology/Oncology, University Children's Hospital, Klinikum Oldenburg AöR, Carl von Ossietzky University, Oldenburg, Germany.

Background: Patients with childhood-onset craniopharyngioma (CP) often suffer from tumour or treatment-related hypothalamic lesions (HL). These lesions may alter production of oxytocin, which plays a major role in the regulation of eating behaviour and body composition.

Objective: In CP with different degrees of HL, we investigated associations between HL, eating behaviour/eating attitudes, and oxytocin saliva concentrations (OSC). Read More

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http://dx.doi.org/10.1111/ijpo.12527DOI Listing

The Association Between Telemedicine and Emergency Department (ED) Disposition: A Stepped Wedge Design of an ED-Based Telemedicine Program in Critical Access Hospitals.

J Rural Health 2019 Apr 23. Epub 2019 Apr 23.

Department of Health Management and Policy, University of Iowa College of Public Health, Iowa City, Iowa.

Purpose: To study the relationship between the availability and activation of emergency department-based telemedicine (teleED) and patient disposition in Critical Access Hospitals (CAHs).

Methods: A non randomized stepped wedge design examined 133,396 ED visits in 15 CAHs that subscribe to a single teleED provider. Data were available for at least 12 months prior to teleED implementation and at least 12 months of post-implementation. Read More

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http://dx.doi.org/10.1111/jrh.12370DOI Listing

Emerging translational science discoveries, clonal approaches and treatment trends in chronic myeloproliferative neoplasms.

Hematol Oncol 2019 Apr 23. Epub 2019 Apr 23.

University of California Irvine, Irvine, CA, USA.

The 60 American Society of Hematology (ASH) held in San Diego in December 2018 was followed by the 13 Post-ASH chronic myeloproliferative neoplasms (MPNs) workshop on the 4 -5 December 2018. This closed annual workshop, first introduced in 2006 by Goldman and Mughal, was organized in collaboration with Alpine Oncology Foundation and allowed experts in preclinical and clinical research in the chronic MPNs to discuss the current scenario, including relevant presentations at ASH, and address pivotal open questions that impact translational research and clinical management. This review is based on the presentations and deliberations at this workshop, and rather than provide a resume of the proceedings, we have selected some of the important translational science and treatment issues which require clarity. Read More

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http://dx.doi.org/10.1002/hon.2622DOI Listing

Swimming Upstream: Disentangling the Association between Alcohol Intake and Venous Thromboembolism.

Thromb Haemost 2019 Apr 23. Epub 2019 Apr 23.

Diagnostic Centre, University Research Clinic for Innovative Patient Pathways, Silkeborg Regional Hospital, Silkeborg, Denmark.

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http://dx.doi.org/10.1055/s-0039-1687881DOI Listing

Understanding the Heterogeneity of Labor and Delivery Units: Using Design Thinking Methodology to Assess Environmental Factors that Contribute to Safety in Childbirth.

Am J Perinatol 2019 Apr 23. Epub 2019 Apr 23.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, California.

Objective:  There is limited research exploring the relationship between design and patient safety outcomes, especially in maternal and neonatal care. We employed design thinking methodology to understand how the design of labor and delivery units impacts safety and identified spaces and systems where improvements are needed.

Study Design:  Site visits were conducted at 10 labor and delivery units in California. Read More

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http://dx.doi.org/10.1055/s-0039-1685494DOI Listing

The Roles of Neuropilin 2/VEGF-C Axis in a Series of Recurrent Lymphangioma.

Eur J Pediatr Surg 2019 Apr 23. Epub 2019 Apr 23.

The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, United States.

Objective:  Vascular endothelial growth factor (VEGF) and its receptor act as a major contributor to lymphangioma, but their role on nonrecurrent and recurrent lymphangiomas remain unclear. We aim to investigate those factors in the generation of recurrent lymphangioma.

Materials And Methods:  Patients diagnosed with lymphangioma from January 2005 to December 2012 in our hospital were collected and divided into nonrecurrent and recurrent lymphangiomas. Read More

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http://dx.doi.org/10.1055/s-0039-1687869DOI Listing

Current Insights into the Potential Misuse of Platelet-based Applications for Doping in Sports.

Int J Sports Med 2019 Apr 23. Epub 2019 Apr 23.

Hull York Medical School, Centre for Atherothrombotic and Metabolic Disease, Hull, United Kingdom of Great Britain and Northern Ireland.

Platelet-based applications are currently used for the delivery of growth factors and other biomolecules as autologous biomaterials in regenerative medicine and cosmetic therapies. Many studies have revealed that platelet-based applications such as platelet-rich plasma and platelet releasate exhibit beneficial biological effects after a sports injury or trauma when administered locally by intramuscular injections. At present, treatment of the public, patients and athletes with platelet-based applications is permitted and regulated by the Food and Drug Administration and the World Anti-Doping Agency. Read More

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http://dx.doi.org/10.1055/a-0884-0734DOI Listing

Urospermia indicating ectopic ureters in breeding dogs - 3 cases.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2019 Apr 23;47(2):119-124. Epub 2019 Apr 23.

Evidensia Veterinary Clinic for Small Animals Norderstedt.

An Entlebucher Mountain Dog (57 months old, case 1), a Labrador Retriever (24 months, case 2) and an Irish Soft-Coated Wheaten Terrier (31 months old, case 3) were presented for breeding soundness evaluation to the clinic. During semen collection in all 3 dogs, the pre-secretion and the sperm-rich fraction showed normal consistency and colour, whereas the prostatic secretion (3 rd ejaculate fraction) appeared strikingly yellow. In cases 1 and 2, a severely decreased sperm motility (asthenozoospermia) and an increased amount of abnormal spermatozoa (teratozoospermia), and in case 3, a moderately decreased total sperm count (oligozoospermia) were detected. Read More

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http://dx.doi.org/10.1055/a-0862-5443DOI Listing

Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth.

Fetal Diagn Ther 2019 Apr 23:1-10. Epub 2019 Apr 23.

Implantation and Placental Development Laboratory, Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Victoria, Australia,

Objective: The aim of this study was to investigate the potential utility of serum HtrA1 and HtrA3, serine proteases that are highly expressed in the developing placenta, at 15 and 20 weeks of gestation for predicting later development of adverse pregnancy outcomes of preeclampsia (PE), gestational hypertension (GHT), preterm birth (PTB), and small for gestational age (SGA) birth.

Methods: This is a nested case control study of 665 samples (330 controls, 335 cases) from the Adelaide SCOPE cohort. The cases included were 92 PE, 71 GHT, 56 PTB, and 116 SGA. Read More

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http://dx.doi.org/10.1159/000497144DOI Listing

Physician and Surrogate Agreement with Assisted Dying and Continuous Deep Sedation in Advanced Dementia in Switzerland.

Neurodegener Dis 2019 Apr 23:1-8. Epub 2019 Apr 23.

University Research Priority Program "Dynamics of Healthy Aging," University of Zurich, Zurich, Switzerland.

Background: Assisted dying and continuous deep sedation (CDS) are controversial practices. Little is known about the perceptions of physicians and surrogates about these practices for patients with advanced dementia.

Objectives: To describe and compare physician and surrogate agreement with the use of assisted dying and CDS in advanced dementia. Read More

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http://dx.doi.org/10.1159/000499113DOI Listing

The Association between Chronicity of Migraine and Complementary and Alternative Medication Use: The Turkish Perspective.

Eur Neurol 2019 Apr 23;81(1-2):24-29. Epub 2019 Apr 23.

Department of Neurology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey,

Background And Purpose: The term of Complementary and Alternative Medication (CAM) is described by patients as all types of practices to prevent or treat illnesses, which are not currently considered as a part of conventional medicine. Although the advance in treatment for migraine, some patients prefer CAM therapies due to their concerns about conventional therapies. The aim of this study was to evaluate the association between CAM use and chronicity of migraine among Turkish migraineurs. Read More

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https://www.karger.com/Article/FullText/499910
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http://dx.doi.org/10.1159/000499910DOI Listing
April 2019
4 Reads

Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation.

Ann Nutr Metab 2019 Apr 23;74(4):313-321. Epub 2019 Apr 23.

Department of Endocrinology, The First Affiliated Hospital of Kunming Medical University, Kunming, China,

Background: Exercise therapy plays an important role in the prevention and treatment of type 2 diabetes (T2DM). The mechanism of exercise therapy in the improvement of glycolipid metabolism of T2DM is very complex and not completely clear.

Summary: Exercise training improves the whole body metabolic health in patients with T2DM, leading to an increase in glycolipid uptake and utilization, improved insulin sensitivity, optimized body mass index, and modulated DNA methylation, etc. Read More

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http://dx.doi.org/10.1159/000500110DOI Listing

Upper Limb Motor Function Affects the Outcome after Treatment with Botulinum Toxin A.

Eur Neurol 2019 Apr 23;81(1-2):30-36. Epub 2019 Apr 23.

Department of Rehabilitation Medicine I, School of Medicine, Fujita Health University, Toyoake, Japan.

Background: Treatment with Botulinum toxin A (BoNT-A) is effective in decreasing upper limb spasticity.

Objective: This study aimed to determine the differences in the outcome based on the upper limb motor function before BoNT-A treatment.

Methods: The subjects were 61 patients who underwent BoNT-A treatment for upper limb spasticity. Read More

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http://dx.doi.org/10.1159/000499907DOI Listing

Effects of Acupuncture Treatment on Lower Limb Spasticity in Patients Following Hemorrhagic Stroke: A Pilot Study.

Eur Neurol 2019 Apr 23;81(1-2):5-12. Epub 2019 Apr 23.

Department of Traditional Chinese Medicine, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Background And Purpose: Lower limb spasticity is often a significant problem in stoke rehabilitation. The purpose of this study was to investigate the effects of acupuncture treatment on lower limb spasticity in patients following hemorrhagic stroke.

Methods: Fifty-nine patients following hemorrhagic stroke were randomized to receive acupuncture treatment combined with conventional treatment (treatment group [TG]) or conventional treatment only (control group [CG]). Read More

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http://dx.doi.org/10.1159/000499133DOI Listing

Cross-Sectional Area Analysis of the Head of the Caudate Nucleus in Huntington's Disease.

Eur Neurol 2019 Apr 23;81(1-2):13-18. Epub 2019 Apr 23.

Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan,

Background: Caudate nucleus atrophy is a well-known neuroimaging feature of Huntington's disease (HD). Some researchers have reported a decrease in the volume of the striatum on magnetic resonance images (MRIs) even in the presymptomatic stage of the disease. Despite the many neuroimaging studies on HD, the optimal method for measuring the caudate nucleus area on MRIs and the most effective cutoff values for diagnosing HD remain unclear. Read More

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http://dx.doi.org/10.1159/000499909DOI Listing

Microbleeds of Lacunar Infarction and Middle Cerebral Artery Flow Velocity of Branch Atheromatous Disease Are Essential Factors of Stroke Etiology.

Eur Neurol 2019 Apr 23;81(1-2):19-23. Epub 2019 Apr 23.

Department of Neurology, Jikei University School of Medicine, Tokyo, Japan.

Background: Although subcortical infarction patients sometimes show larger infarction size than the definition of small vessel occlusion (SVO), there are no specific predictors of larger size. The aim of this study was to identify the factors, including magnetic resonance imaging (MRI) and ultrasonographic parameters, to predict larger subcortical infarction.

Methods: Consecutive patients with acute supratentorial subcortical infarction were studied. Read More

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http://dx.doi.org/10.1159/000494672DOI Listing

The Controlling Nutritional Status Score and Postoperative Complication Risk in Gastrointestinal and Hepatopancreatobiliary Surgical Oncology: A Systematic Review and Meta-Analysis.

Ann Nutr Metab 2019 Apr 23;74(4):303-312. Epub 2019 Apr 23.

Department of Surgery, Division of HPB and Transplant Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

The controlling nutritional status (CONUT) score is associated with prognosis in gastrointestinal (GI) cancer patients, but the clinical significance of the CONUT score for postoperative short-term outcome remains controversial. The aim of this study was to investigate the impact of the CONUT score on postoperative outcomes in patients with GI and hepatopancreatobiliary (HPB) cancers. We conducted a systematic literature search of Embase, Medline Ovid, Web of Science, Cochrane CENTRAL, and Google Scholar. Read More

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http://dx.doi.org/10.1159/000500233DOI Listing

The Role of Ancillary Techniques in Pulmonary Cytopathology.

Acta Cytol 2019 Apr 23:1-9. Epub 2019 Apr 23.

Department of Pathology, New York University School of Medicine, New York, New York, USA,

Ancillary techniques play an essential role in pulmonary cytopathology. Immunoperoxidase and special stains are by far the most common ancillary techniques used in cytopathology; however, the role of molecular diagnosis is growing, especially in the fields of pulmonary oncology and infectious disease. In this article, we review the uses of ancillary techniques in lung tumor diagnosis, lung tumor classification, predictive marker determination, primary versus metastasis differential diagnosis, and infectious organism detection. Read More

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http://dx.doi.org/10.1159/000498889DOI Listing

Tri-ortho-cresyl phosphate induces autophagy of mouse ovarian granulosa cells.

Reproduction 2019 Apr 1. Epub 2019 Apr 1.

J Chen, Department of Physiology, Medical College of Nanchang University, Nanchang, China.

Tri-ortho -cresyl phosphate (TOCP) has been widely used as plasticizers, plastic softeners, and flame-retardants in industry and reported to have male reproductive toxicology. However, it is still unknown whether TOCP affects the female reproductive system and its underlying mechanism. In the present study, we found that TOCP exposure significantly decreased ovarian coefficient, caused disintegration and depletion of the granulosa cells in the ovary tissue and significantly inhibited the level of serum estradiol (E2). Read More

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https://rep.bioscientifica.com/view/journals/rep/aop/rep-18-
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http://dx.doi.org/10.1530/REP-18-0456DOI Listing
April 2019
1 Read

Antenatal dexamethasone treatment transiently alters diastolic function in the mouse fetal heart.

J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

K Chapman, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, United Kingdom of Great Britain and Northern Ireland.

Endogenous glucocorticoid action is important in the structural and functional maturation of the fetal heart. In fetal mice, although glucocorticoid concentrations are extremely low before E14.5, glucocorticoid receptor (GR) is expressed in the heart from E10. Read More

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http://dx.doi.org/10.1530/JOE-18-0666DOI Listing

Myelopathy after zoster virus infection in immunocompetent patients: A case series.

J Spinal Cord Med 2019 Apr 23:1-5. Epub 2019 Apr 23.

a Department of Neurology , Habib Bourguiba University Hospital , Sfax , Tunisia.

Context: After primary infection, varicella zoster virus (VZV) becomes latent in ganglionic neurons. If immunity declines, VZV is reactivated and can spread to the dermatome depending from this ganglion and in some cases to the spinal cord. Myelopathy is rare and may develop in the absence of skin rash making the diagnosis very difficult. Read More

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http://dx.doi.org/10.1080/10790268.2019.1607053DOI Listing

Innate Immune Responses to in the Airway.

J Interferon Cytokine Res 2019 Apr 23. Epub 2019 Apr 23.

Department of Pathology and Laboratory Medicine, Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, New Jersey.

is an emerging opportunistic pathogen that has risen to become a serious global threat, prevalent in health care settings and the community, which results in high morbidity and mortality rates. Its alarming expansion of antibiotic resistance is one of the most problematic traits of and as so, this bacterium has been classified as a serious threat and high priority target by the CDC. The most common types of infections induced by this pathogen include pneumonia (both hospital and community acquired), bacteremia, skin and soft tissue, urinary tract infections, endocarditis, and meningitis. Read More

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http://dx.doi.org/10.1089/jir.2019.0008DOI Listing

Ameliorative Effects of on Cognitive Impairment Via Enhancing Cholinergic Functions and Brain-Derived Neurotrophic Factor Expression in -Amyloid-Induced Mice.

J Med Food 2019 Apr 23. Epub 2019 Apr 23.

1 Department of Biochemistry and Molecular Biology, Center for Chronic Metabolic Disease Research, Brain Korea 21 Project for Medical Sciences, Severance Medical Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Alzheimer's disease accounts for the majority of dementia and shows hallmarks such as sequential cognitive dysfunction and abnormal behavior. (DM) has traditionally been used to treat a variety of diseases in East Asia. The aim of this study was to assess the therapeutic effects of DM on brain neuron damage and on cognitive deficit in neuronal cell induced by A in mice. Read More

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http://dx.doi.org/10.1089/jmf.2018.4375DOI Listing

In New-Onset Diabetes Mellitus, Metformin Reduces Fat Accumulation in the Liver, But Not in the Pancreas or Pericardium.

Metab Syndr Relat Disord 2019 Apr 23. Epub 2019 Apr 23.

1 First Department of Medicine, University of Szeged, Szeged, Hungary.

Nonalcoholic fatty pancreas and liver disease (NAFPD and NAFLD) and pericardial adipose tissue (PAT) are often associated with type 2 diabetes mellitus (T2DM). Our aim was to evaluate the incidence rate of NAFLD and NAFPD, PAT size, and the effect of metformin treatment on NAFLD, NAFPD, and PAT in new-onset T2DM (NODM). Seventeen patients with NODM and 10 subjects used as a control group were involved in the study. Read More

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http://dx.doi.org/10.1089/met.2018.0086DOI Listing

Regulation of PGLYRP1 and TREM-1 during Progression and Resolution of Gingival Inflammation.

JDR Clin Trans Res 2019 Apr 23:2380084419844937. Epub 2019 Apr 23.

1 Section of Periodontology and Dental Prevention, Division of Oral Diseases of Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.

Introduction: The triggering receptor expressed on myeloid cells 1 (TREM-1) signaling pathway is stimulated by bacteria and, together with its putative ligand peptidoglycan recognition protein 1 (PGLYRP1), propagates proinflammatory responses.

Objectives: We aimed to evaluate the TREM-1/PGLYRP1/interleukin (IL)-1β regulation in response to biofilm accumulation and removal in an experimental human gingivitis model.

Methods: The study (n = 42 participants, mean age: 23. Read More

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http://journals.sagepub.com/doi/10.1177/2380084419844937
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http://dx.doi.org/10.1177/2380084419844937DOI Listing
April 2019
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Resolvin D2 elevates cAMP to increase intracellular [Ca] and stimulate secretion from conjunctival goblet cells.

FASEB J 2019 Apr 23:fj201802467R. Epub 2019 Apr 23.

Schepens Eye Research Institute, Massachusetts Eye and Ear-Harvard Medical School, Boston, Massachusetts, USA.

Under physiologic conditions, conjunctival goblet cells (CGCs) secrete mucins into the tear film to preserve ocular surface homeostasis. Specialized proresolving mediators (SPMs), like resolvins (Rvs), regulate secretion from CGCs and actively terminate inflammation. The purpose of this study was to determine if RvD2 stimulated mucin secretion and to investigate the cellular signaling components. Read More

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http://dx.doi.org/10.1096/fj.201802467RDOI Listing

Acupuncture for Primary Insomnia: An Updated Systematic Review of Randomized Controlled Trials.

J Altern Complement Med 2019 Apr 23. Epub 2019 Apr 23.

1 Beijing University of Chinese Medicine, Beijing, China.

Acupuncture as one of the alternative therapies for insomnia is widely used in Asia and increasingly employed in western countries. To provide updated evidence from randomized controlled trials (RCTs) on the effectiveness and safety of acupuncture for primary insomnia. A comprehensive literature search in 11 databases was conducted from January 2008 to October 2017. Read More

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http://dx.doi.org/10.1089/acm.2018.0046DOI Listing

The optimization of sintering treatment on bovine-derived bone grafts for bone regeneration: in vitro and in vivo evaluation.

J Biomed Mater Res B Appl Biomater 2019 Apr 23. Epub 2019 Apr 23.

Department of Prothodontics, The Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Modifications of sintering temperature and treatment time of bovine-derived bone grafts affect their physicochemical properties and further influence biological activity. Three different temperature sintered bovine-derived bone grafts: group I (300 °C 3 h), group II (300 °C 3 h plus 530 °C 6 h), and group III (300 °C 3 h plus 1000 °C 2 h) and Bio-Oss® were characterized and then compared in vitro for their effects on bone marrow stromal cells (BMSCs) migration, proliferation, and differentiation as estimated by cell migration assay, Alkaline phosphatase (ALP) activity assay, and Alizarin red staining. Further, the four bone grafts were implanted into the calvarial defects of rabbits to evaluate bone regeneration and graft degradation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.34387
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http://dx.doi.org/10.1002/jbm.b.34387DOI Listing
April 2019
1 Read

Mathematical predictions of oxygen availability in micro- and macro-encapsulated human and porcine pancreatic islets.

J Biomed Mater Res B Appl Biomater 2019 Apr 23. Epub 2019 Apr 23.

Department of Surgery, University of California, Irvine, Orange, California.

Optimal function of immunoisolated islets requires adequate supply of oxygen to metabolically active insulin producing beta-cells. Using mathematical modeling, we investigated the influence of the pO on islet insulin secretory capacity and evaluated conditions that could lead to the development of tissue anoxia, modeled for a 300 μm islet in a 500 μm microcapsule or a 500 μm planar, slab-shaped macrocapsule. The pO was used to assess the part of islets that contributed to insulin secretion. Read More

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http://dx.doi.org/10.1002/jbm.b.34393DOI Listing

Clinical features and prognosis of microscopic polyangiitis with usual interstitial pneumonia compared with idiopathic pulmonary fibrosis.

Clin Respir J 2019 Apr 23. Epub 2019 Apr 23.

Department of Respiratory and Critical Care Medicine, Beijing, Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing, Chao-Yang Hospital-Beijing Institute of Respiratory Medicine, Capital Medical University, No. 8 Gongren Tiyuchang South Road, Beijing, 100020, P.R. China.

Introduction: Pulmonary involvement in microscopic polyangiitis (MPA) is common, little is known about the clinical features of MPA with interstitial pneumonia (MPA-IP).

Objectives: This study aimed to explore the prevalence of microscopic polyangiitis associated usual interstitial pneumonia (UIP)(MPA-UIP) and compare its clinical features and prognosis with those of MPA-non-UIP and idiopathic pulmonary fibrosis (IPF).

Methods: A total of 73 patients with MPA-IP were identified and divided into MPA-UIP patients and MPA-non-UIP patients. Read More

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http://dx.doi.org/10.1111/crj.13032DOI Listing

Economic evaluations of onchocerciasis interventions: a systematic review and research needs.

Trop Med Int Health 2019 Apr 23. Epub 2019 Apr 23.

London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, UK.

Objective: To provide a systematic review of economic evaluations that have been conducted for onchocerciasis interventions, to summarise current key knowledge and to identify research gaps.

Method: A systematic review of the literature was conducted on the 8 of August 2018 using the PubMed (MEDLINE) and ISI Web of Science electronic databases. No date or language stipulations were applied to the searches. Read More

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http://dx.doi.org/10.1111/tmi.13241DOI Listing

Do Electronic Health Record Prompts Increase Take-Home Naloxone Administration for Emergency Department Patients After an Opioid Overdose?

Addiction 2019 Apr 23. Epub 2019 Apr 23.

Department of Emergency Medicine, University of Pittsburgh School of Medicine.

Background And Aims: Distribution of take-home-naloxone (THN) to emergency department (ED) patients who have survived an opioid overdose could reduce future opioid mortality but is not commonly performed. We examined whether electronic health record (EHR) prompts provided to ED physicians when discharging a patient after an opioid overdose could improve THN distribution.

Design: Interrupted time series analysis to compare the percentage of OD patients who received THN during the 11 months before and after implementation of an EHR prompt on June 18, 2017. Read More

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http://dx.doi.org/10.1111/add.14635DOI Listing

Airway management of Congenital Pulmonary Airway Malformation Resection in neonates and infants: A case cohort study.

Paediatr Anaesth 2019 Apr 23. Epub 2019 Apr 23.

Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, USA.

Background: Anesthetic management of congenital pulmonary airway malformation has not been well described in the literature whether one lung ventilation is indicated during thoracoscopic lobectomy and if so, what is the best technique to achieve one lung ventilation.

Aim: We describe the variables with the two commonly performed surgical techniques thoracoscopic lobectomy and open thoracotomy from our institutional database to assess the role of lung isolation and the preferable method of lung isolation technique for congenital pulmonary airway malformation resections.

Methods: After institutional review board approval, fetal-center records were reviewed retrospectively from January 2010 to July 2016 for patients who underwent congenital pulmonary airway malformation resection. Read More

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http://dx.doi.org/10.1111/pan.13648DOI Listing

Long-term safety of a weekly and monthly subcutaneous buprenorphine depot (CAM2038) in the treatment of adult outpatients with opioid use disorder.

Addiction 2019 Apr 23. Epub 2019 Apr 23.

Camurus AB, Lund, Sweden.

Aims: To assess long-term safety of subcutaneous buprenorphine (CAM2038) weekly and monthly depots.

Design: Phase 3, open-label, observational, multicentre 48-week trial (ClinicalTrials.gov NCT02672111). Read More

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http://dx.doi.org/10.1111/add.14636DOI Listing
April 2019
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Small alarmones (p)ppGpp regulate virulence associated traits and pathogenesis of Salmonella enterica serovar Typhi.

Cell Microbiol 2019 Apr 23:e13034. Epub 2019 Apr 23.

Division of Clinical Medicine, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India.

How Salmonella enterica serovar Typhi (S. Typhi), an important human pathogen survives the stressful microenvironments inside the gastrointestinal tract and within macrophages remains poorly understood. We report here that S. Read More

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http://dx.doi.org/10.1111/cmi.13034DOI Listing

Inhibition of adhesion-specific genes by Solidago virgaurea extract causes loss of Candida albicans biofilm integrity.

J Appl Microbiol 2019 Apr 23. Epub 2019 Apr 23.

Université Aix-Marseille, AP-HM, IRD, VITROME, IHU Méditerranée Infection, Marseille, France.

Aims: Candida albicans biofilms are commonly associated to severe oral infections. We previously discovered that a crude extract from the Solidago virgaurea plant (SV-extract) was a potent inhibitor of C. albicans biofilm formation. Read More

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http://dx.doi.org/10.1111/jam.14289DOI Listing

Glucokinase and the potential of glucokinase activation in type 2 diabetes.

J Diabetes 2019 Apr 23. Epub 2019 Apr 23.

Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.

No abstract is available for this article. This article is protected by copyright. All rights reserved. Read More

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http://dx.doi.org/10.1111/1753-0407.12937DOI Listing

Effectiveness and Safety of Thromboprophylaxis with Enoxaparin for Prevention of Pregnancy-Associated Venous Thromboembolism.

J Thromb Haemost 2019 Apr 23. Epub 2019 Apr 23.

National Women's Health, Auckland City Hospital, Auckland.

Background: Low-molecular weight heparin (LMWH) is used to prevent pregnancy-associated venous thromboembolism (PA-VTE) but there are limited data to inform which women require thromboprophylaxis in pregnancy and debate about which LMWH dose is effective and safe.

Aims: To evaluate the efficacy and rate of complications using enoxaparin for thromboprophylaxis in a cohort of women at risk of PA-VTE managed between 1999 and 2014 at National Women's Hospital, a tertiary obstetric referral centre in Auckland, New Zealand.

Methods: A retrospective, observational study of women who received thromboprophylaxis with enoxaparin for prevention of PA-VTE while under the care of the obstetric or maternal fetal medicine team. Read More

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http://dx.doi.org/10.1111/jth.14452DOI Listing

Construct Cyan Fluorescence by De Novo Tripeptides: An In Vitro Mutation Study on the Role of Single Amino Acid Residues and Their Sequence.

Chembiochem 2019 Apr 23. Epub 2019 Apr 23.

Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, P. R. China., Yuexiu Road, CHINA.

Amino acids are a natural choice as building blocks for developing bio-functional entities owing to their superior diversity and versatile physicochemical properties compared to nucleotide bases. A simple permutation of amino acids creates a broad palette of proteins that are successfully engineered as useful bio-functional agents. For example, the intrinsic ultraviolet fluorescence of phenylalanine (F) and tryptophan (W) have been engineered to emit in the visible spectrum [1, 2], that has broad applications as imaging/sensing probes, photothermal therapy agents, optogenetic switches, etc. Read More

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http://dx.doi.org/10.1002/cbic.201900166DOI Listing

Value of supranormal function on Tc-MAG3 scan in pediatric patients with obstructive hydronephrosis.

BJU Int 2019 Apr 23. Epub 2019 Apr 23.

Department of Pediatric Surgery, Pediatric Urology Division, Hospital Sant Joan de Déu. Universitat de Barcelona, Spain.

Objectives: To study related factors and clinical significance of supranormal function in pediatric patients with PUJ obstruction, and to predict which factors cause renal function overestimation.

Patients And Methods: Patients who underwent pyeloplasty from 2012 to 2017 were prospectively collected. Variables were compared between patients with and without supranormal function on 99mTc-MAG-3 scan (differential renal function ≥55%). Read More

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http://dx.doi.org/10.1111/bju.14781DOI Listing

The Emerging Role of Nurse Practitioners and Physician Assistants in Liver Transplantation.

Liver Transpl 2019 Apr 23. Epub 2019 Apr 23.

Division of Transplant Medicine, Mayo Clinic, Jacksonville, Florida.

The evolution of nurse practitioners (NP) and physician assistants (PA) in the United States continues to progress. NPs and PAs have expanded from primary care practices, to medical and surgical specialties, provide acute care in hospitals and intensive care units, and serve as educators, lobbyists, and researchers. Questions have arisen from NP/PA leaders, physician leaders, and administrators on how to best implement a successful NP/PA model within their practice. Read More

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http://dx.doi.org/10.1002/lt.25474DOI Listing

Nurses' perceptions of pain management adequacy in mechanically ventilated patients.

J Clin Nurs 2019 Apr 23. Epub 2019 Apr 23.

STTI Phi Gamma Chapter, Nursing Department, Steyer School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Aims And Objectives: To examine how nurses' knowledge of behaviors indicating pain in mechanically ventilated patients and self-perceived collaboration between nurses and physicians affect the adequacy of departmental pain management.

Background: Pain management is a vital factor of medical treatment in a hospital setting. Inadequate pain management requires attention both from a patient-focused perspective and from a departmental one. Read More

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http://dx.doi.org/10.1111/jocn.14896DOI Listing

Exploratory analysis of prognostic factors for lenvatinib in radioiodine-refractory differentiated thyroid cancer.

Head Neck 2019 Apr 23. Epub 2019 Apr 23.

Department of Medical Oncology/Hematology, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Multitarget kinase inhibitors (m-TKI), including lenvatinib, are now available as treatment options for radioiodine-refractory differentiated thyroid cancer (RR-DTC). However, the optimal timing of treatment initiation with m-TKI in these patients remains to be defined.

Methods: We retrospectively reviewed the clinical records of 30 consecutive patients with RR-DTC. Read More

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http://dx.doi.org/10.1002/hed.25784DOI Listing

Surgical nurses' perceptions and experiences of a medications and oral restrictions policy change: a focus group study.

J Clin Nurs 2019 Apr 23. Epub 2019 Apr 23.

Surgical Clinical Service Unit, Austin Health, Melbourne, Australia.

Aims And Objectives: To explore the perceptions and experiences of surgical nurses before and after introducing the Medications and Oral Restrictions Policy (the Policy).

Background: The Policy was developed following extensive consultation, and evidence-based strategies were considered for its implementation. However, it is possible uptake did not meet expectations. Read More

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http://dx.doi.org/10.1111/jocn.14898DOI Listing

From embryonic stem cells to induced pluripotent stem cells - ready for clinical therapy?

Authors:
Jing Hu Jimei Wang

Clin Transplant 2019 Apr 23:e13573. Epub 2019 Apr 23.

Neonatal department, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200011, China.

Embryonic stem cells and induced pluripotent stem cells have increasingly important roles in many different fields of research and medicine. Major areas of impact include improved in vitro disease models, drug screening, and the development of cell-based clinical therapies. Here we review the generation and uses of embryonic stem cells compared to induced pluripotent stem cells, and discuss their advantages and limitations. Read More

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http://dx.doi.org/10.1111/ctr.13573DOI Listing

HBcrAg to detect HBV reactivation in heart transplant recipients with past HBV infection: a pilot study.

Clin Transplant 2019 Apr 23:e13574. Epub 2019 Apr 23.

Internal Medicine, University of Campania "L. Vanvitelli", Naples, Italy.

Hepatitis B core-related antigen (HBcrAg) has been proposed as a new marker of HBV replication. We analyzed HBcrAg dynamics in 15 heart transplant recipients with active or prior HBV infection and correlated it with quantitative (QT)-HBsAg and HBV-DNA pre- and post-transplant. Serum HBcrAg was detected in HBsAg/HBV-DNA-positive subjects but not in recipients with past HBV infection. Read More

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http://dx.doi.org/10.1111/ctr.13574DOI Listing

Parent and child perception of quality of life in a randomized controlled peanut oral immunotherapy trial.

Pediatr Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway.

Background: Improved quality of life (QoL) after oral immunotherapy (OIT) in peanut allergic children is often reported by their parents, while the child's perspective is less clear.

Objective: We aimed to explore if two years of OIT improved QoL in children with peanut allergy and to identify factors influencing change in QoL.

Methods: In the open labelled TAKE-AWAY peanut OIT trial including children with anaphylaxis to peanuts, 57 were randomized to OIT and 20 to observation. Read More

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http://dx.doi.org/10.1111/pai.13066DOI Listing

The BEST criteria improve sensitivity for detecting positive cultures in residual blood components cultured in suspected septic transfusion reactions.

Transfusion 2019 Apr 23. Epub 2019 Apr 23.

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Background: Culturing residual blood components after suspected septic transfusion reactions guides management of patients and cocomponents. Current practice, accuracy of provider vital sign assessment, and performance of the AABB culture criteria are unknown. A multicenter international study was undertaken to investigate these issues and develop improved culture criteria. Read More

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http://dx.doi.org/10.1111/trf.15317DOI Listing
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