5,281,720 results match your criteria Medicine & Health Rhode Island [Journal]

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[Reconstruction of neglected Achilles tendon rupture: flexor hallucis longus transfer versus gastrocnemius turn-down flaps].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):542-546

Institute of Sports Medicine, Peking University Third Hospital, Beijing 100191, China.

To compare the outcome of either flexor hallucis longus transfer or turn-down of proximal Achilles tendon tissue repair in treating chronic Achilles tendon rupture. The clinical data of 21 patients who underwent repair of Myerson type Ⅲ chronic Achilles tendon rupture at Peking University Sports Medicine Research Institute from May 2012 to March 2015 were retrospectively analyzed. Among them, 11 cases were treated with flexor hallucis longus (FHL) transfer, and 10 cases were treated with gastrocnemius turn-down flaps repair. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.013DOI Listing
February 2019

[Modified Western Ontario and McMaster University Osteoarthritis Index Scale used in patients with knee osteoarthritis].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):537-541

Department of Traditional Chinese Medicine, the 2nd Affiliated Hospital of Harbin Medical University, Harbin 150081, China.

To modify Western Ontario and McMaster University Osteoarthritis Index (WOMAC) for more accurate evaluation of patients with knee osteoarthritis in China,and its reliability and validity were measured. The WOMAC was modified through reviewing relevant literatures and practical survey.Total of 120 patients were enrolled in this study. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.012DOI Listing
February 2019

[Different care models and symptom progression of Alzheimer's disease in China].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):532-536

Department of Psychiatry, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

To compare the differences of cognitive function, daily living ability and neuropsychiatric symptoms in patients with sporadic type of Alzheimer's disease (AD) under different care modes, and find the most favorable care mode for delaying the progress of disease. One hundred and twenty cases of AD patients were divided into three groups: Spouse Care Group, Adult Child Care Group and Nursing Home Group. Medical history collection and scale evaluation were carried out by trained specialists on 3 groups of patients and caregivers. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.011DOI Listing
February 2019

[Correlation between polymorphism of CYP19A1, GSTM1, GSTT1 and GSTP1 gene and endometriosis].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):515-519

Reproductive Medicine Center, the Affiliated Hospital of Inner Mongolia Medical University, Huhehot 010050, China.

To study the association between polymorphisms in CYP19A1 rs2899470, GSTM1, GSTT1, and GSTP1 rs1695 and the development of endometriosis. Between October 2015 and October 2017, 262 endometriosis patients and 275 control subjects were recruited from the Affiliated Hospital of Inner Mongolia Medical University. Genotyping was conducted using polymerase chain reaction-coupled with restriction fragment length polymorphism and multiplex allele specific polymerase chain reaction. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.008DOI Listing
February 2019

[Application of stretched exponential diffusion-weighted imaging model in quantitative diagnosis of nonalcoholic fatty liver disease: in a rabbit model].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):500-504

Department of Radiology, Northern Jiangsu People's Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, China.

To evaluate the feasibility of diffusion parameters obtained from mono-exponential and stretched exponential diffusion-weighted imaging models in staging of nonalcoholic fatty liver disease and compare the diagnosis ability of nonalcoholic steatohepatitis. Thirty-two 12 -week-old male New Zealand rabbits, about 2.5 kg of each, were randomly divided into five groups. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.005DOI Listing
February 2019

[Establishment of rat model of cardiorenal syndrome by transabdominal subtotal nephrectomy].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):447-452

Department of Cardiovascular Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.

To evaluate the changes of rat renal function and cardiac function after transabdominal subtotal nephrectomy (STNx) and provide an ideal animal model for the study of chronic kidney disease (CKD) and cardiorenal syndrome (CRS). The SD rats (male, 5-6 weeks) were randomly divided into Sham group (10) and STNx group (10). The rats from Sham group underwent sham surgery, and the right nephrectomy plus the 2/3 left kidney artery ligation through abdominal incision were performed in the rats from STNx group. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.013DOI Listing
February 2019

[Activation of GPER inhibts proliferation and autophagy in prostatic epithelial cells].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):419-422

Department of Urology, the First Affiliated Hospital of Guangzhou Medical College, Guangdong Key Laboratory of Urology, Guangzhou 510230, China.

To investigate the effect of G protein-coupled estrogen receptor (GPER) on proliferation and autophagy in prostatic epithelial cells. Cell Counting Kit-8 (CCK8) assay was used to observe the growth of BPH-1 and RWPE-1 cells after treating with or not with estradiol or GPER selective agonist G1. Autophagy was quantified with Western blot and Cyto-ID autophagy detection kit after treating with estradiol, G1 or both G1 and G15 in the same cells. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.007DOI Listing
February 2019

[Current view on obstructive sleep apnea in idiopathic pulmonary fibrosis].

Authors:
Q Y Li A L Song

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):416-418

Wuxi Branch of Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Wuxi 214000, China.

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.006DOI Listing
February 2019

[Sleep and sleep related breathing disorders in chronic obstructive pulmonary disease].

Authors:
W Wang

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):411-413

Department of Respiratory and Critical Care Medicine, the First Hospital of China Medical University, Shenyang 110001, China.

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.004DOI Listing
February 2019

[Sleep and sleep breathing problems in lung cancer patients].

Authors:
X L Zhang B Y Chen

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):407-410

Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China.

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.003DOI Listing
February 2019

[Focus on complications of flexible ureteroscopic lithotripsy].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):404-406

Department of Urology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China.

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.002DOI Listing
February 2019

[Recognize sleep disorder in patients with common respiratory diseases].

Authors:
F Han B Y Chen

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):401-403

Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China.

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.001DOI Listing
February 2019

Quantitative CT-derived vessel metrics in idiopathic pulmonary fibrosis: A structure-function study.

Respirology 2019 Feb 20. Epub 2019 Feb 20.

Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria.

Background And Objective: This study aimed to investigate whether quantitative lung vessel morphology determined by a new fully automated algorithm is associated with functional indices in idiopathic pulmonary fibrosis (IPF).

Methods: A total of 152 IPF patients had vessel volume, density, tortuosity and heterogeneity quantified from computed tomography (CT) images by a fully automated algorithm. Separate quantitation of vessel metrics in pulmonary arteries and veins was performed in 106 patients. Read More

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http://dx.doi.org/10.1111/resp.13485DOI Listing
February 2019

Intensity-modulated radiation therapy dose prescription and reporting: Sum and substance of the International Commission on Radiation Units and Measurements Report 83 for veterinary medicine.

Vet Radiol Ultrasound 2019 Feb 20. Epub 2019 Feb 20.

Division of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Institutions' adherence to protocol, quality assurance, and radiation parameter reporting are key to adequately interpret and compare treatment outcomes in radiation oncology. In 2017, the editorial board for Veterinary Radiology & Ultrasound adapted author guidelines on "technical information for radiation therapy (RT)". These guidelines provide a framework to report the RT treatment process in manuscripts resulting from veterinary clinical trials. Read More

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http://dx.doi.org/10.1111/vru.12722DOI Listing
February 2019

The prevalence and diagnostic classification of mixed features in patients with major depressive episodes: A multicenter study based on the DSM-5.

Int J Methods Psychiatr Res 2019 Feb 20:e1773. Epub 2019 Feb 20.

Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Objectives: The purpose of this study was to evaluate the prevalence of mixed features using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and to examine how patients with mixed states would be classified using the DSM-5.

Methods: In total, 12 hospitals participated in this study, and data on the demographic characteristics and clinical diagnoses of patients treated between October 2013 and September 2016 were obtained. We reviewed the data for opposite-polarity symptoms according to the DSM-5 criteria and the research-based diagnostic criteria. Read More

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http://dx.doi.org/10.1002/mpr.1773DOI Listing
February 2019

Tolerating uncertainty about conceptual models of uncertainty in health care.

J Eval Clin Pract 2019 Feb 20. Epub 2019 Feb 20.

Program for Evidence-based Medicine & Comparative Effectiveness Research, Department of Supportive Medicine, Department of Hematology, City of Hope National Medical Center, Duarte, California, USA.

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http://dx.doi.org/10.1111/jep.13110DOI Listing
February 2019

Clonal expansion of hepatic progenitor cells and differentiation into hepatocyte-like cells.

Dev Growth Differ 2019 Feb 20. Epub 2019 Feb 20.

Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Hepatic progenitor cells (HPCs) in adult liver are promising for treatment of liver diseases. A biliary-derived HPC population in adult mice has been characterized by co-expression of stem cell marker Sry (sex determining region Y)-box 9 (SOX9) and biliary marker cytokeratin 7 (CK7). However, isolation of these HPCs in adult healthy liver without any selection procedures remains a big challenge in this field. Read More

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http://dx.doi.org/10.1111/dgd.12596DOI Listing
February 2019

Digital cholangioscopy-guided laser versus mechanical lithotripsy for large bile duct stone removal after failed papillary large-balloon dilation: a randomized study.

Endoscopy 2019 Feb 20. Epub 2019 Feb 20.

Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.

Background:  Endoscopic papillary large-balloon dilation (EPLBD) allows for the complete removal of large common bile duct (CBD) stones without fragmentation; however, a significant proportion of very large stones and stones floating above a tapering CBD require lithotripsy. Mechanical lithotripsy and cholangioscopy-guided laser lithotripsy are both effective for stone fragmentation. This study aimed to directly compare, for the first time, the efficacy of these two techniques in terms of stone clearance rate, procedure duration, patient radiation exposure, and safety. Read More

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http://dx.doi.org/10.1055/a-0848-8373DOI Listing
February 2019

Lithopedion Causing Intestinal Obstruction in a 71-Year-Old Woman: A Case Report Litopedia causando obstrução intestinal em idosa de 71 anos: relato de caso.

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):129-132. Epub 2019 Feb 20.

Division of Medicine, Fortaleza Health Squadron, Força Aérea Brasileira, Fortaleza, CE, Brazil.

Ectopic pregnancy is the leading cause of pregnancy-related death during the first trimester, and it occurs in 1 to 2% of pregnancies. Over 90% of ectopic pregnancies are located in the fallopian tube. Abdominal pregnancy refers to an ectopic pregnancy that has implanted in the peritoneal cavity, external to the uterine cavity and fallopian tubes. Read More

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http://dx.doi.org/10.1055/s-0038-1676060DOI Listing
February 2019

Occult Urinary Incontinence Treatment: Systematic Review and Meta-analysis-Brazilian Guidelines.

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):116-123. Epub 2019 Feb 20.

Faculty of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil.

Objective:  To evaluate if performing anti-incontinence procedures during surgical anterior and/or apical prolapse correction in women with asymptomatic urinary incontinence (UI) may prevent stress urinary incontinence (SUI) postoperatively.

Methods:  We have performed a systematic review of articles published in the PubMed, Cochrane Library, and Lilacs databases until March 31, 2016. Two reviewers performed the data collection and analysis, independently. Read More

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http://dx.doi.org/10.1055/s-0038-1676842DOI Listing
February 2019

The Use of Mobile Educational Tools to Improve Antimicrobial Prescription for the Treatment of Acute Pyelonephritis in Pregnancy: A Retrospective Cross-sectional Study.

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):97-101. Epub 2019 Feb 20.

Graduate Program in Medicine and Health Sciences, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.

Objective:  To analyze the prescription of antimicrobial agents for pregnant women admitted into the obstetrics service who presented with acute pyelonephritis.

Methods:  Three cross-sectional studies were performed comparing the prescription of antimicrobials for pyelonephritis in pregnant women in the time periods evaluated (2010-2011: 99 patients evaluated; 2013: 116 patients evaluated; 2015: 107 patients evaluated), at the Hospital Fêmina, Porto Alegre, in the state of Rio Grande do Sul, Brazil. The analysis was performed before and after the promotion of an institutional protocol for the treatment of pyelonephritis during pregnancy, and on a third occasion after the introduction of a smartphone-based mobile educational tool. Read More

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http://dx.doi.org/10.1055/s-0039-1678590DOI Listing
February 2019

Syphilis in Pregnancy: The Reality in a Public Hospital.

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):90-96. Epub 2019 Feb 20.

Department of Fetal Medicine, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.

Objective:  The present study assessed epidemiological and obstetrical data from pregnant women with syphilis at the Hospital de Clínicas of the Universidade Federal do Triângulo Mineiro (UFTM, in the Portuguese acronym), describing this disease during pregnancy and its vertical transmission for future healthcare actions.

Methods:  Records from pregnant women who had been admitted to the Obstetrics Department of the Hospital de Clínicas of the UFTM and were diagnosed with syphilis between 2007 and 2016 were reviewed. A standardized form was used to collect epidemiological, obstetric data and outcomes of congenital infection. Read More

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http://dx.doi.org/10.1055/s-0038-1676569DOI Listing
February 2019

Answering the Call to Accelerate the Elimination of Cervical Cancer.

Authors:
Joanna M Cain

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):67. Epub 2019 Feb 20.

School of Medicine, Department of Obstetrics and Gynecology, University of Massachusetts, Massachusetts, United States.

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http://dx.doi.org/10.1055/s-0039-1679864DOI Listing
February 2019

Using Electronic Health Records to Identify Adverse Drug Events in Ambulatory Care: A Systematic Review.

Appl Clin Inform 2019 Jan 20;10(1):123-128. Epub 2019 Feb 20.

Department of Global Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, United States.

Objective:  We identified the methods used and determined the roles of electronic health records (EHRs) in detecting and assessing adverse drug events (ADEs) in the ambulatory setting.

Methods:  We performed a systematic literature review by searching PubMed and Google Scholar for studies on ADEs detected in the ambulatory setting involving any EHR use published before June 2017. We extracted study characteristics from included studies related to ADE detection methods for analysis. Read More

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http://dx.doi.org/10.1055/s-0039-1677738DOI Listing
January 2019

[Artificial intelligence and machine learning].

Authors:
Peter Hahn

Handchir Mikrochir Plast Chir 2019 Feb 20. Epub 2019 Feb 20.

Vulpiusklinik.

Machine learning (ML) is the ability of computers to learn from data without being programmed explicitly for that purpose, and to apply the acquired knowledge to unknown cases. The application of ML in medicine will increase exponentially in the years to come. Doctors should have some basic knowledge of ML. Read More

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http://dx.doi.org/10.1055/a-0826-4789DOI Listing
February 2019

Varicella Zoster Virus Induces Differential Cell-Type Specific Responses in Human Corneal Epithelial Cells and Keratocytes.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):704-711

Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, United States.

Purpose: While VZV DNA and antigen have been detected in acute and chronic VZV keratitis, it is unclear whether productive infection of corneal cells is ongoing or whether residual, noninfectious VZV antigens elicit inflammation. Herein, we examined VZV-infected primary human corneal epithelial cells (HCECs) and keratocytes (HKs) to elucidate the pathogenesis of VZV keratitis.

Methods: HCECs and HKs were mock- or VZV infected. Read More

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http://dx.doi.org/10.1167/iovs.18-25801DOI Listing
February 2019

Age-Related Alterations in Retinal Tissue Perfusion and Volumetric Vessel Density.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):685-693

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.

Purpose: To determine age-related alterations in the retinal tissue perfusion (RTP) and volumetric vessel density (VVD) in healthy subjects.

Methods: Total 148 healthy subjects (age 18 to 83 years) were enrolled and divided into four groups (G1, <35 years; G2, 35 ∼ 49 years; G3, 50 ∼ 64 years; and G4, ≥65 years). The RTP and VVD were measured at the macula. Read More

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http://dx.doi.org/10.1167/iovs.18-25864DOI Listing
February 2019

KLF4 Regulates Corneal Epithelial Cell Cycle Progression by Suppressing Canonical TGF-β Signaling and Upregulating CDK Inhibitors P16 and P27.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):731-740

Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.

Purpose: Krüppel-like factor 4 (KLF4) promotes corneal epithelial (CE) cell fate while suppressing mesenchymal properties. TGF-β plays a crucial role in cell differentiation and development, and if dysregulated, it induces epithelial-mesenchymal transition (EMT). As KLF4 and TGF-β regulate each other in a context-dependent manner, we evaluated the role of the crosstalk between KLF4 and TGF-β-signaling in CE homeostasis. Read More

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http://dx.doi.org/10.1167/iovs.18-26423DOI Listing
February 2019

Hemodynamic Response of the Three Macular Capillary Plexuses in Dark Adaptation and Flicker Stimulation Using Optical Coherence Tomography Angiography.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):694-703

Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States.

Purpose: To assess retinal microvascular reactivity during dark adaptation and the transition to ambient light and after flicker stimulation using optical coherence tomography angiography (OCTA).

Methods: Fifteen eyes of 15 healthy participants were dark adapted for 45 minutes followed by OCTA imaging in the dark-adapted state. After 5 minutes of normal lighting, subjects underwent OCTA imaging. Read More

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http://dx.doi.org/10.1167/iovs.18-25478DOI Listing
February 2019

The ubiquitin ligase KBTBD8 regulates PKM1 levels via Erk1/2 and Aurora A to ensure oocyte quality.

Aging (Albany NY) 2019 Feb 20. Epub 2019 Feb 20.

State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, Jiangsu, P.R. China.

Tight control of energy metabolism is essential for normal cell function and organism survival. PKM (pyruvate kinase, muscle) isoforms 1 and 2 originate from alternative splicing of PKM pre-mRNA. They are key enzymes in oxidative phosphorylation and aerobic glycolysis, respectively, and are essential for ATP generation. Read More

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http://dx.doi.org/10.18632/aging.101802DOI Listing
February 2019

Delivery-associated sepsis: trends in prevalence and mortality.

Am J Obstet Gynecol 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL.

Background: Sepsis is a leading cause of pregnancy-related mortality. Previous studies have reported an increased prevalence of sepsis during pregnancy. Despite national campaigns to increase sepsis awareness, there is a lack of pregnancy-specific guidelines. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.002DOI Listing
February 2019

Obesity and Laboratory Aspirin Resistance in High Risk Pregnant Women Treated with Low Dose Aspirin.

Am J Obstet Gynecol 2019 Jan 29. Epub 2019 Jan 29.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH.

Background: Low dose aspirin (LDA) is used for preeclampsia (PE) prevention in high risk women, but the precise mechanism and optimal dose is unknown. Evidence suggests that an imbalance in prostacyclin and thromboxane A (TXA) plays a key role in the pathogenesis of PE. Aspirin has a dose-dependent effect blocking production of TXA, a potent stimulator of platelet aggregation and promoter of vasoconstriction. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.01.222DOI Listing
January 2019

Reconstruction of effective connectivity in the case of asymmetric phase distributions.

J Neurosci Methods 2019 Feb 17. Epub 2019 Feb 17.

University of Cologne, Institute of Zoology, Heisenberg Research Group of Computational Neuroscience - Modeling Neural Network Function, Zülpicher Str. 47b, 50674 Cologne, Germany; Research Centre Jülich, Institute of Neuroscience and Medicine (INM-3), Cognitive Neuroscience, 52425 Jülich, Germany. Electronic address:

Background: The interaction of different brain regions is supported by transient synchronization between neural oscillations at different frequencies. Different measures based on synchronization theory are used to assess the strength of the interactions from experimental data. One method of estimating the effective connectivity between brain regions, within the framework of the theory of weakly coupled phase oscillators, was implemented in Dynamic Causal Modelling (DCM) for phase coupling (Penny et al. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2019.02.009DOI Listing
February 2019

Smaller Change in Psychological Readiness to Return to Sport Is Associated With Second Anterior Cruciate Ligament Injury Among Younger Patients.

Am J Sports Med 2019 Feb 20:363546519825499. Epub 2019 Feb 20.

School of Allied Health, La Trobe University, Melbourne, Australia.

Background:: Lower psychological readiness to return to sport has been reported for younger patients (≤20 years) who go on to a second anterior cruciate ligament (ACL) injury. However, changes in psychological readiness and specific psychological responses associated with second injury have not been identified.

Purpose/hypothesis:: To identify changes in psychological readiness over time associated with a second ACL injury. Read More

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http://dx.doi.org/10.1177/0363546519825499DOI Listing
February 2019

Using A Developmental Ecology Framework to Align Fear Neurobiology Across Species.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychology, Columbia University, New York, NY 10027, USA; email: , , ,

Children's development is largely dependent on caregiving; when caregiving is disrupted, children are at increased risk for numerous poor outcomes, in particular psychopathology. Therefore, determining how caregivers regulate children's affective neurobiology is essential for understanding psychopathology etiology and prevention. Much of the research on affective functioning uses fear learning to map maturation trajectories, with both rodent and human studies contributing knowledge. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095727DOI Listing
February 2019

Estrogen, Stress, and Depression: Cognitive and Biological Interactions.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Geriatric Research, Education, and Clinical Center, Tennessee Valley Veterans Affairs Medical Center, Nashville, Tennessee 37212, USA.

This article reviews the interactions of estrogen changes and psychosocial stress in contributing to vulnerability to major depressive disorder (MDD) in women. Estrogen modulates brain networks and processes related to changes in stress response, cognition, and emotional dysregulation that are core characteristics of MDD. Synergistic effects of estrogen on cognitive and emotional function, particularly during psychosocial stress, may underlie the association of ovarian hormone fluctuation and depression in women. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095557DOI Listing
February 2019

History of Psychopharmacology.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California 90095-1759, USA; email:

We live in an age of psychopharmacology. One in six persons currently takes a psychotropic drug. These drugs have profoundly shaped our scientific and cultural understanding of psychiatric disease. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095514DOI Listing
February 2019

High-resolution Regulatory Maps Connect Vascular Risk Variants to Disease Related Pathways.

Circ Genom Precis Med 2019 Feb 20. Epub 2019 Feb 20.

Science for Life Laboratory, KTH - Royal Institute of Technology, Solna, Sweden.

Background: Genetic variant landscape of coronary artery disease (CAD) is dominated by non-coding variants among which many occur within putative enhancers regulating the expression levels of relevant genes. It is crucial to assign the genetic variants to their correct genes both to gain insights into perturbed functions and better assess the risk of disease.

Methods: In this study, we generated high-resolution genomic interaction maps (~750 bases) in aortic endothelial, smooth muscle cells and THP-1 macrophages stimulated with lipopolysaccharide using Hi-C coupled with sequence capture targeting 25,429 features including variants associated with CAD. Read More

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http://dx.doi.org/10.1161/CIRCGEN.118.002353DOI Listing
February 2019

International Divergence in Gene Patenting.

Annu Rev Genomics Hum Genet 2019 Feb 20. Epub 2019 Feb 20.

Centre for IT and IP Law, KU Leuven, 3000 Leuven, Belgium.

This review explores the recent divergence in international patent law relating to the patenting of genes and related subject matter. This divergence stems primarily from decisions of the highest courts in the United States and Australia on the eligibility of patent claims relating to the BRCA gene sequences. Patent offices, courts, and policy makers have struggled for many years to clearly articulate the bounds of patent claims on isolated and synthetic DNA and related products and processes, including methods for their use in genetic diagnostics. Read More

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http://dx.doi.org/10.1146/annurev-genom-083118-015112DOI Listing
February 2019

Multipotent Mesenchymal Stromal Cells and Lung Disease: Not Ready for Prime Time.

Ann Am Thorac Soc 2019 Feb 20. Epub 2019 Feb 20.

University of Miami - Miller School of Medicine, Pulmonary and Critical Care Medicine, Miami, Florida, United States.

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http://dx.doi.org/10.1513/AnnalsATS.201811-843PSDOI Listing
February 2019

Alterations in Synovial Fluid Biomarker Levels in Knees With Meniscal Injury as Compared With Asymptomatic Contralateral Knees.

Am J Sports Med 2019 Feb 20:363546519825498. Epub 2019 Feb 20.

Division of Sports Medicine, Department of Orthopaedic Surgery, NYU Langone Health, New York, New York, USA.

Background:: Changes in the joint microenvironment after an injury to the articular surface of the knee have been implicated in the pathogenesis of osteoarthritis. While prior studies focused on changes in this microenvironment after anterior cruciate ligament ruptures, few have explored the biomarker changes that occur in the setting of meniscal injuries.

Purpose:: To determine whether meniscal injury results in significant alterations to synovial fluid biomarker concentrations as compared with noninjured contralateral knees. Read More

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http://dx.doi.org/10.1177/0363546519825498DOI Listing
February 2019

Kratom exposures reported to United States poison control centers: 2011-2017.

Clin Toxicol (Phila) 2019 Feb 20:1-8. Epub 2019 Feb 20.

a Center for Injury Research and Policy , The Research Institute at Nationwide Children's Hospital , Columbus , OH , USA.

Context: Kratom, or Mitragyna speciosa, is a plant indigenous to Southeast Asia that has gained national attention in the United States for its increased use in the self-management of opioid withdrawal and pain, as well as for concerns about its safety.

Methods: This study analyzes exposures to kratom reported to poison control centers (PCCs) in the United States during 2011-2017 from the National Poison Data System (NPDS).

Discussion: From 2011 through 2017, 1807 kratom exposures were reported to United States PCCs. Read More

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http://dx.doi.org/10.1080/15563650.2019.1569236DOI Listing
February 2019

Maspin binds to cardiolipin in mitochondria and triggers apoptosis.

FASEB J 2019 Feb 20:fj201802182R. Epub 2019 Feb 20.

Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

A central question in cell biology is how cells respond to stress signals and biochemically regulate apoptosis. One critical pathway involves the change of mitochondrial function and release of cytochrome c to initiate apoptosis. In response to apoptotic stimuli, we found that maspin-a noninhibitory member of the serine protease inhibitor superfamily-translocates from the cytosol to mitochondria and binds to cardiolipin in the inner mitochondrial membrane. Read More

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http://dx.doi.org/10.1096/fj.201802182RDOI Listing
February 2019

Kinetics of Drug Binding and Residence Time.

Annu Rev Phys Chem 2019 Feb 20. Epub 2019 Feb 20.

Department of Pharmacy and Biotechnology, University of Bologna, I-40126 Bologna, Italy; email:

The kinetics of drug binding and unbinding is assuming an increasingly crucial role in the long, costly process of bringing a new medicine to patients. For example, the time a drug spends in contact with its biological target is known as residence time (the inverse of the kinetic constant of the drug-target unbinding, 1/ k). Recent reports suggest that residence time could predict drug efficacy in vivo, perhaps even more effectively than conventional thermodynamic parameters (free energy, enthalpy, entropy). Read More

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http://dx.doi.org/10.1146/annurev-physchem-042018-052340DOI Listing
February 2019

Wearable Sensors for Biochemical Sweat Analysis.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Feb 20. Epub 2019 Feb 20.

Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA; email:

Sweat is a largely unexplored biofluid that contains many important biomarkers ranging from electrolytes and metabolites to proteins, cytokines, antigens, and exogenous drugs. The eccrine and apocrine glands produce and excrete sweat through microscale pores on the epidermal surface, offering a noninvasive means for capturing and probing biomarkers, which reflect hydration state, fatigue, nutrition, and physiological changes. Skin-interfaced wearable sensors capable of real-time in situ sweat collection and analytics provide capabilities for continuous biochemical monitoring in an ambulatory mode of operation. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-114910DOI Listing
February 2019

Direct Oral Anticoagulants for Thromboprophylaxis in Ambulatory Patients with Cancer.

N Engl J Med 2019 Feb;380(8):781-783

From the Internal Vascular and Emergency Medicine-Stroke Unit, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1056/NEJMe1816060DOI Listing
February 2019

Case 6-2019: A 29-Year-Old Woman with Nausea, Vomiting, and Diarrhea.

N Engl J Med 2019 Feb;380(8):772-779

From the Department of Medicine, Boston Medical Center (A.Y.W.), the Department of Medicine, Boston University School of Medicine (A.Y.W.), the Departments of Medicine (S.E.W.) and Pathology (G.E.), Massachusetts General Hospital, and the Departments of Medicine (S.E.W.) and Pathology (G.E.), Harvard Medical School - all in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1816407DOI Listing
February 2019

Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer.

N Engl J Med 2019 Feb;380(8):741-751

From the Massachusetts General Hospital Cancer Center (A.B., S.J.I.) and Dana-Farber Cancer Institute (S.M.T.), Harvard Medical School, Boston; Vanderbilt-Ingram Cancer Center, Nashville (I.A.M., V.G.A.); Weill Cornell Medical College (L.T.V.) and New York-Presbyterian-Columbia University Irving Medical Center (K.K.), New York; University of Colorado Cancer Center, Aurora (J.R.D.); Texas Oncology, Baylor University Medical Center, US Oncology, Dallas (J.O.); Orlando Health University of Florida Health Cancer Center, Orlando (R.L.M., N.C.S.); Yale University School of Medicine, New Haven, CT (A.D.S.); University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco (H.S.R.); Immunomedics, Morris Plains, NJ (D.M.G., R.I., S.W., R.M.S., W.A.W.); and AIS Consulting, Ann Arbor, MI (A.M.S.).

Background: Standard chemotherapy is associated with low response rates and short progression-free survival among patients with pretreated metastatic triple-negative breast cancer. Sacituzumab govitecan-hziy is an antibody-drug conjugate that combines a humanized monoclonal antibody, which targets the human trophoblast cell-surface antigen 2 (Trop-2), with SN-38, which is conjugated to the antibody by a cleavable linker. Sacituzumab govitecan-hziy enables delivery of high concentrations of SN-38 to tumors. Read More

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http://dx.doi.org/10.1056/NEJMoa1814213DOI Listing
February 2019

Once-Daily Plazomicin for Complicated Urinary Tract Infections.

N Engl J Med 2019 Feb;380(8):729-740

From the Justus Liebig University, Giessen, Germany (F.M.E.W.); Achaogen, South San Francisco (D.J.C., A.S.K., D.S.C., K.M.K., T.R.K., L.E.C., I.F.), the David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles (L.G.M.), and Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance (L.G.M.) - all in California; and Vanderbilt University Medical Center, Nashville (J.P.D.).

Background: The increasing multidrug resistance among gram-negative uropathogens necessitates new treatments for serious infections. Plazomicin is an aminoglycoside with bactericidal activity against multidrug-resistant (including carbapenem-resistant) Enterobacteriaceae.

Methods: We randomly assigned 609 patients with complicated urinary tract infections (UTIs), including acute pyelonephritis, in a 1:1 ratio to receive intravenous plazomicin (15 mg per kilogram of body weight once daily) or meropenem (1 g every 8 hours), with optional oral step-down therapy after at least 4 days of intravenous therapy, for a total of 7 to 10 days of therapy. Read More

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http://dx.doi.org/10.1056/NEJMoa1801467DOI Listing
February 2019

Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer.

N Engl J Med 2019 Feb;380(8):720-728

From the Department of Hematology and Medical Oncology, Taussig Cancer Institute and Case Comprehensive Cancer Center, Cleveland Clinic, Cleveland (A.A.K.); the Department of Medicine, Memorial Sloan Kettering Cancer Center (G.A.S., E.M.O.), and Weill Cornell Medical College (G.A.S., E.M.O.), New York; the Thrombosis Research Institute and University College London, London (A.K.K.); University of Texas M.D. Anderson Cancer Center, Houston (S.V.-R.), and U.S. Oncology Research-Texas Oncology, Tyler (H.A.Y.) - both in Texas; the Department of Medicine, Charité Universitätsmedizin Berlin, Berlin (H.R.); the Division of Hematology-Oncology, University of California Davis School of Medicine, Sacramento (T.W.), and the Keck School of Medicine, University of Southern California, Los Angeles (H.A.L.); the Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore (M.B.S.); the University of Washington School of Medicine (D.A.G., N.M.K., G.H.L.), Advanced Cancer Research Group (N.M.K.), and Fred Hutchinson Cancer Research Center (G.H.L.), Seattle; Penn State Cancer Institute, Milton S. Hershey Medical Center, Hershey, PA (C.P.B.); the Department of Cancer Pharmacology, Levine Cancer Institute, Atrium Health, Charlotte, NC (J.N.P.); Janssen Scientific Affairs, Titusville (P.W., P.B., S.K.), and Janssen Research and Development, Raritan (U.V.) - both in New Jersey; the Department of Medicine, McMaster University, Hamilton, ON, Canada (J.E.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (R.M.); and the Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Boston (K.A.B.).

Background: Ambulatory patients receiving systemic cancer therapy are at varying risk for venous thromboembolism. However, the benefit of thromboprophylaxis in these patients is uncertain.

Methods: In this double-blind, randomized trial involving high-risk ambulatory patients with cancer (Khorana score of ≥2, on a scale from 0 to 6, with higher scores indicating a higher risk of venous thromboembolism), we randomly assigned patients without deep-vein thrombosis at screening to receive rivaroxaban (at a dose of 10 mg) or placebo daily for up to 180 days, with screening every 8 weeks. Read More

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http://dx.doi.org/10.1056/NEJMoa1814630DOI Listing
February 2019
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