20,796 results match your criteria Medicine[Journal]


Reporting guidelines: doing better for readers.

Authors:
David Moher

BMC Med 2018 Dec 14;16(1):233. Epub 2018 Dec 14.

Centre for Journalology, Clinical Epidemiology Program, The Ottawa Hospital Research Institute, The Ottawa Hospital - General Campus, 501 Smyth Rd, Room L1288, Ottawa, ON, K1H 8L6, Canada.

There is clear guidance on the responsibilities of editors to ensure that the research they publish is of the highest possible quality. Poor reporting is unethical and directly impacts patient care. Reporting guidelines are a relatively recent development to help improve the accuracy, clarity, and transparency of biomedical publications. Read More

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December 2018

Correction to: Frailty, nutrition-related parameters, and mortality across the adult age spectrum.

BMC Med 2018 Dec 14;16(1):235. Epub 2018 Dec 14.

Centre for Health Care of the Elderly, QEII Health Sciences Centre, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.

The original article [1] contained an error whereby Table 5 within the Appendix is presented incorrectly. This error has now been corrected and Table 5 is presented appropriately. Read More

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December 2018

Ambient air pollution in gastrointestinal endoscopy unit; rationale and design of a prospective study.

Medicine (Baltimore) 2018 Dec;97(49):e13600

Department of Internal Medicine.

Background: A gastrointestinal endoscopy unit is frequently exposed to gastrointestinal gas expelled from patients and electrocoagulated tissue through carbonation for the treatment of gastrointestinal neoplasms or hemostasis of gastrointestinal bleeding. This can be potentially harmful to the health of not only the healthcare personnel but also patients who undergo endoscopic examinations. However, there has been scarce data on air quality in the endoscopy unit. Read More

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December 2018

Retrospective observational study of micro-monovision small incision lenticule extraction (SMILE) for the correction of presbyopia and myopia.

Medicine (Baltimore) 2018 Dec;97(49):e13586

Department of Ophthalmology and Visual Science, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

This study was aimed to evaluate refractive and visual outcomes after micro-monovision small incision lenticule extraction (SMILE) in patients with presbyopia and myopia. In total, 72 patients (144 eyes) with a mean age of 46.0 ± 4. Read More

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December 2018

Prognostic role of neutrophil-lymphocyte ratio in esophageal cancer: A systematic review and meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13585

Department of Thoracic Surgery.

Background: The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in esophageal cancer (EC) remains controversial.

Methods: The aim of this study was to evaluate the association between NLR and oncologic outcome of EC patients through a meta-analysis. A systematic search was performed in PubMed, Web of Science and Embase for relevant studies. Read More

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December 2018
1 Read

Myocardial calcification found in Epstein-Barr viral myocarditis and rhabdomyolysis: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13582

Department of Critical Care Medicine, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, China.

Rationale: The Epstein-Barr (EB) virus has rarely been reported as a cause of fulminant myocarditis. To our knowledge, the present case is the first report on myocardial calcification in EB viral myocarditis and rhabdomyolysis.

Patient Concerns: A 17-year-old man was admitted to the department with fever, chest tightness, and tachypnea that had been present for 2 days. Read More

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December 2018

Pulmonary embolism caused by myasthenia gravis: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13578

Department of Respiratory Medicine, Qinghai University Affiliated Hospital, Xining, China.

Rationale: Pulmonary embolism (PE) is a relatively common disease; however, myasthenia gravis leading to PE has been rarely reported in the literature. We report a case of PE in a patient with myasthenia gravis and discuss the possible mechanism underlying the development of PE. We hypothesize that inflammatory mediators may lead to endothelial injury, resulting in PE or deep venous thrombosis (DVT) in patients with myasthenia gravis. Read More

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December 2018

UGT1A1 genotypes and unconjugated hyperbilirubinemia phenotypes in post-neonatal Chinese children: A retrospective analysis and quantitative correlation.

Medicine (Baltimore) 2018 Dec;97(49):e13576

Department of Pediatrics, Jinshan Hospital of Fudan University, Shanghai, China.

To retrospectively analyze and quantitatively correlate UGT1A1 (bilirubin UDP- glucuronosyltransferase gene) genotypes and unconjugated hyperbilirubinemia (UCH) phenotypes among Chinese children.We retrospectively reviewed UCH patients, quantitatively analyzed genotype-phenotype correlation by comparing with healthy controls. Pfam database, SWISS-model, and Pymol were used for UGT1A1 protein domain analysis and protein modeling for assessing the effect of novel missense variants on protein structure. Read More

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December 2018

Laparoscopic transabdominal preperitoneal technique versus open surgery with the ULTRAPRO Hernia System for the repair of female primary femoral hernias-an observational retrospective study.

Medicine (Baltimore) 2018 Dec;97(49):e13575

Department of General Surgery, Linyi People's Hospital, Linyi, Shandong Province, China.

Femoral hernias (FHs), predominantly seen in females, require surgery for cure. To date, surgical repair of primary FHs in female patients with either open surgery or laparoscopic operation has been poorly documented. We retrospectively investigated the treatment of female primary FHs with open surgery using the ULTRAPRO Hernia System (UHS procedure) or the laparoscopic procedure, namely, the transabdominal preperitoneal (TAPP) technique. Read More

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December 2018

Non-dislocation lunate fracture combined with distal radius fracture: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13574

Department of Orthopedics, The Second Hospital of Jilin University, Changchun, China.

Rationale: Lunate fractures are very rare, accounting for only 0.5% to 6.5% of all carpal fractures. Read More

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December 2018

Incidence and clinical features of patients with peritoneal dialysis peritonitis complicated by bacteremia.

Medicine (Baltimore) 2018 Dec;97(49):e13567

Emergency Department, Chi Mei Medical Center.

The standard treatment of peritoneal dialysis peritonitis (PD peritonitis) is intraperitoneal antibiotic therapy. In patients with PD peritonitis complicated by bacteremia, intraperitoneal antibiotics combined with elective removal of the infected intraperitoneal catheter may be inadequate.We collected data of all patients with PD peritonitis admitted to Chi-Mei Medical Center during a 4-year period. Read More

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December 2018
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Anti-TIF1γ antibody predicted malignancy of thymic tumor with dermatomyositis as an "autoimmune tumor marker": A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13563

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Rationale: An association between inflammatory myopathy and malignancy has been recognized particularly in patients positive for anti-transcription intermediary factor 1γ (TIF1γ) antibody. We report a case of anti-TIF1γ antibody positive dermatomyositis (DM) associated with thymic carcinoma which radiographically mimicked benign tumor.

Patient Concerns: A 72-year-old man presented typical characteristic cutaneous manifestations and proximal muscle weakness with elevated levels of myogenic enzymes. Read More

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December 2018

Pressure management as an occupational stress risk factor in irritable bowel syndrome: A cross-sectional study.

Medicine (Baltimore) 2018 Dec;97(49):e13562

Second Medical Department.

Irritable Bowel Syndrome (IBS) is the most prevalent functional gastrointestinal disorder. Psychosocial stress is one of the pathogenic factors involved in the pathogenesis of IBS. The Pressure Management Indicator (PMI) is a validated questionnaire to analyze all aspects of occupational stress-a model involving sources of pressure, the mechanisms of coping, the personality, and the resulting effects of the interaction between these 3 elements. Read More

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December 2018

Lambda-like ST-segment elevation in acute myocardial infarction triggered by coronary spasm may be a new risk predictor for lethal ventricular arrhythmia: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13561

Department of Cardiology.

Rationale: The lambda-like ST-elevation electrocardiography (ECG) pattern is extremely rare in patients with type 2 myocardial infarction (T2MI) triggered by coronary spasm. When this ECG pattern appears, sudden cardiac death (SCD) caused by lethal ventricular arrhythmia may occur because clinicians do not pay sufficient attention to this phenomenon.

Patient Concerns: We describe a 41-year-old man who presented with steep down-sloping ST-segment elevation, paroxysmal ventricular tachycardia, severe sinus bradycardia, and intermittent complete atrioventricular block on ECG during the sudden recurrence of clinical symptoms. Read More

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December 2018

Thoracic endovascular repair technique for the treatment of patent ductus arteriosus in an elderly patient: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13558

Department of Thoracic and Cardiovascular surgery, College of Medicine, Yeungnam University, Daegu, Korea.

Rationale: Patent ductus arteriosus (PDA) ligation by open surgery is more difficult and dangerous in elderly patients than in infants. Nowadays, simple and safe interventional catheterization technology is used for the closure of uncomplicated isolated PDAs. Therefore, an alternative less invasive therapeutic option must be developed to treat complicated PDA. Read More

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December 2018
1 Read

Impact of healthcare reform on the payer mix among young adult emergency department utilizers across the United States (2005-2015).

Medicine (Baltimore) 2018 Dec;97(49):e13556

Betty and Guy Beatty Center for Integrated Research, Inova Health System.

Before the patient protection and affordable care act (ACA), young adults (20 to 34) had the highest uninsured rates in the United States (US) and frequently sought care in emergency departments (EDs).We aimed to determine if there was a measurable effect of expanded coverage, specifically the dependent coverage provision and Medicaid expansion, on the payer mix of young adults in EDs.We performed a retrospective cross-sectional study of ED utilization among young adults across the US using the national hospital ambulatory medical care survey (NHAMCS) (2005-2015). Read More

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December 2018

Incidence of dysphagia and dysphonia after Hangman's fractures: Evidence from 93 patients.

Medicine (Baltimore) 2018 Dec;97(49):e13552

Department of Orthopedics, West China Hospital.

This research aims to explore the accurate incidence, severity and outcomes of dysphagia and dysphonia after Hangman fractures.A total of 93 patients were included in this study and clinical data were reviewed. The Bazaz grading system (0-None; 1-Mild; 2-Moderate; 3-Severe) was used for dysphagia evaluation and the Voice Handicap Index-10 used to evaluate dysphonia. Read More

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December 2018

Primary extra-nodal non-Hodgkin lymphoma in buttock soft tissue: A rare case report.

Medicine (Baltimore) 2018 Dec;97(49):e13550

Head of the Central Laboratory of Hebei University, Hebei province, China.

Rationale: Primary extra-nodal non-Hodgkin lymphoma (PE-NHL) arising in the region of the buttocks is rare. After reviewing the literature from the last 20 years, we found only 3 reported lymphomas originating from soft tissue of the buttocks. In our case, positron emission tomography/computed tomography (PET/CT) was performed for the first time, both before and after treatment, to determine the initial stage of PE-NHL and the curative effects of treatment. Read More

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December 2018

Meta-analysis of the prognostic value of long non-coding RNA PVT1 for cancer patients.

Medicine (Baltimore) 2018 Dec;97(49):e13548

Department of Orthopedics.

Background: Plasmacytoma variant translocation 1 (PVT1) is reported to be dysregulated in various cancers. Therefore, this meta-analysis was performed to clarify its utility as a prognosis marker in malignant tumors.

Methods: Electronic databases, including PubMed, OVID, Cochrane Library, and Web of Science databases, were retrieved from inception to December 16, 2017. Read More

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December 2018
2 Reads

Association between MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270 polymorphisms and retinoblastoma susceptibility.

Medicine (Baltimore) 2018 Dec;97(49):e13547

Department of Ophthalmology, the First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, China.

Retinoblastoma (Rb) is the most common intra-ocular malignancy in children. The association of rs2279744, and rs937283 in MDM2 gene, and p21 rs1801270 polymorphism and RB development have been demonstrated. To provide a comprehensive assessment of and to clarify associations between the 3 SNPs (MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270) and the risk of RB, we performed a meta-analysis of all the eligible case-control studies. Read More

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December 2018

Laparoscopic extracorporeal repair without a mesh of parasternal diaphragmatic hernia in an elderly woman: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13546

Department of Thoracic Surgery, The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, China.

Rationale: The case of parasternal diaphragmatic hernia is relatively rare in adults. The best way for the treatment of diaphragmatic hernia is to receive operation, yet which surgical method is the best remains unclear.

Patient Concerns: An elderly woman in the hospital was complaining about upper abdominal pain that was complicated by the parasternal diaphragmatic hernia. Read More

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December 2018

A long time radiological follow-up of neuronal intranuclear inclusion disease: Two case reports.

Medicine (Baltimore) 2018 Dec;97(49):e13544

Department of Radiology, The First Affiliated Hospital, Nanchang University.

Rationale: Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disease identified with diffusion-weighted imaging (DWI) high-intensity signal in magnetic resonance imaging (MRI). The disappearance of the abnormal signal is extremely rare.

Patient Concerns: We present the 2 cases of patients, both of them were suffering from heterogeneous symptoms. Read More

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December 2018

Serial measurements of KL-6 for monitoring activity and recurrence of interstitial pneumonia with anti-aminoacyl-tRNA synthetase antibody: A retrospective cohort study.

Medicine (Baltimore) 2018 Dec;97(49):e13542

Department of Molecular and Internal Medicine.

The aim of this study was to evaluate whether serial measurements of serum Krebs von den Lungen-6 (KL-6) could be used to monitor disease activity and to detect recurrence in patients with interstitial pneumonia (IP) with anti-aminoacyl-tRNA synthetase antibodies (ARS-IP).This retrospective cohort study included 44 patients with ARS-IP. Thirty-six patients had serial data of blood tests and pulmonary function tests. Read More

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December 2018

Nocardial spinal epidural abscess with lumbar disc herniation: A case report and review of literature.

Medicine (Baltimore) 2018 Dec;97(49):e13541

Department of Spine Surgery.

Rationale: Nocardial spinal epidural abscess is rare. The diagnosis is often difficult to make and, if delayed, poses a high risk of long-term disability. Nocardial spinal epidural abscess with severe lumbar disc herniation has not previously been reported. Read More

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December 2018

Metanephric adenoma with low apparent diffusion coefficient value mimicking renal cell carcinoma: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13539

Division of Emergency and Critical Care Radiology, Department of Medical Imaging and Intervention.

Rationale: Metanephric adenoma (MA) is a rare and often benign tumor. Most MAs were misdiagnosed as renal cell carcinomas (RCCs) preoperatively. Diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) mapping can help to differentiate benign and malignant tumors. Read More

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December 2018
5.723 Impact Factor

Incomplete intestinal obstruction as an initial and persistent presentation in chronic inflammatory demyelinating polyneuropathy: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13538

Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei.

Rationale: Autonomic symptoms are not uncommon in chronic inflammatory demyelinating polyneuropathy (CIDP), but they are mostly mild and transient and are overshadowed by somatic manifestations. Here, we report a very unusual case of CIDP with severe autonomic symptom, intestinal obstruction, as initial and persistent symptom which responded well to high-dose glucocorticoid and intravenous immunoglobulin treatment.

Patient Concerns: We described a patient with CIDP with precedent and long-lasting incomplete intestinal obstruction. Read More

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December 2018

The impact of lymphovascular invasion in patients with prostate cancer following radical prostatectomy and its association with their clinicopathological features: An updated PRISMA-compliant systematic review and meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13537

Department of Urology, Affiliated Jiang-yin Hospital of the Southeast University Medical College, Jiang-yin, Jiangsu Province, China.

Objective: Numerous studies have shown that lymphovascular invasion (LVI) is linked to biochemical recurrence (BCR) in prostate cancer (PCa) patients following radical prostatectomy (RP). However, the actual clinicopathological impacts of LVI remain unclear. Thus, we performed a meta-analysis to evaluate the pathologic and prognostic impacts of LVI in PCa patients. Read More

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December 2018
1 Read

A new scoring model predicting macroscopic vascular invasion of early-intermediate hepatocellular carcinoma.

Medicine (Baltimore) 2018 Dec;97(49):e13536

Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University.

Macroscopic vascular invasion cannot be properly predicted in advance in hepatocellular carcinoma patients based on clinical characteristics and imaging features.To develop a predictive scoring model of macroscopic vascular invasion in hepatocellular carcinoma patients after transcatheter arterial chemoembolization combined with radiofrequency ablation based on specific laboratory and tumor indicators.A predictive scoring model, which estimates the incidence of macroscopic vascular invasion at 1-year follow-up, was constructed based on a derivation cohort of 324 patients with hepatocellular carcinoma; a validation cohort of 120 patients was prospectively included. Read More

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December 2018

Comparison of anchor screw fixation versus mini-plate fixation in unilateral expansive open-door laminoplasty for the treatment of multi-level cervical spondylotic myelopathy.

Medicine (Baltimore) 2018 Dec;97(49):e13534

Department of Spine Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Study Design: Systematic review and meta-analysis.

Background: Anchor screw fixation and mini-plate fixation are widely used in unilateral open-door laminoplasty. There is a great controversy over the preferred fixation method. Read More

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December 2018

Cardiac tamponade after radiofrequency ablation for hepatocellular carcinoma: Case report and literature review.

Medicine (Baltimore) 2018 Dec;97(49):e13532

Department of Internal Medicine, Chonnam National University Medical School.

Rationale: Radiofrequency ablation (RFA) is a safe and effective local treatment modality with a low complication rate and is commonly used to treat hepatocellular carcinoma (HCC). The clinical outcome of RFA may be closely related to the location, size, and shape of index tumors, and major complications, including hemorrhage, liver abscess, infarction, visceral organ perforation, hemothorax, pneumothorax, tumoral seeding, and hepatic failure. Cardiac tamponade is a rare and serious life-threatening complication associated with RFA. Read More

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December 2018
2 Reads

Factors associated with preschool workers' willingness to continue working.

Medicine (Baltimore) 2018 Dec;97(49):e13530

Center for Child Mental Health Care and Education.

In industrialized countries, the turnover rate of preschool workers is extremely high and now represents a social problem. Consequently, it has become important to promote stable early care and educational environments for this population. Several factors related to working environments are known to affect turnover intention; however, the specific factors related to turnover intention among preschool workers have not yet been identified. Read More

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December 2018

Association between Helicobacter pylori infection and Sjögren syndrome: A meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13528

First Clinical Medical College of Nanjing Medical University.

Background: Helicobacter pylori has been proved as a risk factor of many diseases. There are some researches trying to find connection between H. pylori and Sjögren syndrome (SS). Read More

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December 2018

Influence of thermal ablation of hepatic metastases from gastric adenocarcinoma on long-term survival: Systematic review and pooled analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13525

Department of Surgery, 2nd Affiliated Hospital, Zhejiang University School of Medicine.

The objectives of this systematic review and pooled analysis were to examine long-term survival, morbidity, and mortality following thermal ablation of gastric cancer hepatic metastases and to identify prognostic factors that improve survival.Patients with hepatic metastases from gastric cancer are traditionally treated with palliative chemotherapy. Surgical resection is an alternative treatment of hepatic metastases. Read More

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December 2018

Hyperamylasemia may indicate the presence of ovarian carcinoma: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13520

Department of Gynecology and Obstetrics, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.

Rationale: Reports of malignant ovarian tumor with hyperamylasemia are very rare. We present a patient with hyperamylasemia who was diagnosed with a malignant ovarian tumor.

Patient Concerns: A 46-year-old woman was hospitalized complaining of a 2-day history of abdominal discomfort and fever. Read More

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December 2018
1 Read

Gender specific effect of CETP rs708272 polymorphism on lipid and atherogenic index of plasma levels but not on the risk of coronary artery disease: A case-control study.

Medicine (Baltimore) 2018 Dec;97(49):e13514

Department of Pediatrics, No. 2 Hospital of Changzhou, Changzhou, Jiangsu, China.

Numerous studies have shown a relationship between cholesteryl ester transfer protein (CETP) polymorphism in the synthesis of high-density lipoprotein cholesterol (HDL-C) and the coronary artery disease (CAD) susceptibility, but the results have remained inconsistent. In addition, there was no study exploring the relationship between CETP polymorphisms and atherogenic index of plasma (AIP) levels.We conducted a case-control study to evaluate the relationship between CETP rs708272 polymorphism and CAD risk and lipid levels in Chinese Han population. Read More

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December 2018

Analysis of PTEN expression and promoter methylation in Uyghur patients with mild type 2 diabetes mellitus.

Medicine (Baltimore) 2018 Dec;97(49):e13513

Department of Endocrinology and Metabolism.

Phosphatase and tension homolog deleted on chromosome 10 (PTEN) was considered as a promising target in type 2 diabetes mellitus (T2DM) because of its negative effects on insulin resistance. Alteration in DNA methylation is thought to play a role in the pathogenesis of T2DM. The aim of the present study was to quantitatively evaluate the promoter methylation of PTEN in Uyghur patients with mild T2DM. Read More

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December 2018

Relationship of atopic dermatitis with stroke and myocardial infarction: A meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13512

Department of Neurology, Jiangxi Provincial People's Hospital.

Background: Lots of previous reports have suggested a potential association of atopic dermatitis (AD) with stroke and myocardial infarction (MI). However, the result is still controversial, Consequently, we conducted this meta-analysis to estimate the relationship of AD with Stroke and MI.

Methods: PubMed, Embase, and Web of Science databases were searched from inception to June 2018. Read More

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December 2018
2 Reads

Comparison the efficacy of hemorrhage control of Surgiflo Haemostatic Matrix and absorbable gelatin sponge in posterior lumbar surgery: A randomized controlled study.

Medicine (Baltimore) 2018 Dec;97(49):e13511

Department of Orthopedics, West China Hospital, Sichuan University.

Objective: To compare the hemostatic effect of hematostatic agent Surgiflo and absorbable gelatin sponge (AGS) in posterior lumbar surgery.

Methods: A total of 60 cases were recruited during August 2016 and June 2017 according to the inclusion and exclusion criteria. Patients were randomly allocated to the Surgiflo Haemostatic Matrix (SHM) group or the AGS group (AGS) by computer-generated randomization codes. Read More

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December 2018
1 Read

A case report on complete cure of recurrent primary canaliculitis by 4-snip punctoplasty and canalicular curettage.

Authors:
Min Ho Kim Ho Ra

Medicine (Baltimore) 2018 Dec;97(49):e13508

Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Rationale: For the treatment of primary canaliculitis, 1,2,3-snip punctoplasty and canalicular curettage are commonly used; however, a recurrence rate of 6.6% to 22% has been reported. Herein, we describe a case of recurrent primary canaliculitis that was completely cured by 4-snip punctoplasty and canalicular curettage. Read More

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December 2018

Fascia iliaca compartment block versus intravenous analgesic for positioning of femur fracture patients before a spinal block: A PRISMA-compliant meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13502

Graduate Institute of Clinical Medicine.

Background: Fascia iliaca compartment block (FICB) provides an analgesic option for positioning before spinal anesthesia in patients suffering from a femur fracture. The evidence supporting FICB is still not well established. The aim of our study is to assess the efficacy and safety of FICB comparing with intravenous analgesic (IVA) on the quality for positioning before spinal anesthesia in participants with a femur fracture. Read More

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December 2018
1 Read

Impact of coronary plaque geometry on plaque vulnerability and its association with the risk of future cardiovascular events in patients with chest pain undergoing coronary computed tomographic angiography-the GEOMETRY study: Protocol for a prospective clinical trial.

Medicine (Baltimore) 2018 Dec;97(49):e13498

Department of Medical Clinic III - Internal Medicine, University of Medicine and Pharmacy 'Gr.T.Popa', Iasi, Romania.

Introduction: Coronary computed tomography angiography (CCTA) has emerged as a valuable noninvasive imaging tool for assessing atheromatous plaque morphology and composition, and several CCTA features have been validated as reliable indicators of the plaque-associated risk. However, the role of lesion geometry as a CCTA feature of plaque vulnerability has not been investigated so far.

Material And Methods: Here we present the study protocol of the GEOMETRY trial, a prospective, single center, cohort study in which we aim to investigate the relationship between plaque geometry (as expressed by cross-sectional and longitudinal plaque eccentricity) and the risk for major adverse cardiac events (MACE) during 2 years of follow-up, in order to validate plaque eccentricity as a new CCTA marker of coronary plaque vulnerability. Read More

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December 2018

Associations between DNAH1 gene polymorphisms and male infertility: A retrospective study.

Medicine (Baltimore) 2018 Dec;97(49):e13493

Center for Reproductive Medicine.

Genetic abnormalities could account for 10% to 15% of male infertility cases, so increasing attention is being paid to gene mutations in this context. DNAH1 gene polymorphisms are highly correlated with astheno-teratozoospermia, but limited information has been reported on pathogenic variations in DNAH1 in the Chinese population. We explored 4 novel variations of the DNAH1 gene in Chinese infertile patients. Read More

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December 2018

Increased nerve twigs in small intestinal mucosa with programmed cell death-ligand 1 and somatostatin receptor type 2A expression in recurrent Crohn disease: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13492

Rationale: Inflammatory bowel disease (IBD) patients manifest symptoms of disturbed gut function, such as neural sensory-motor changes. Programmed cell death-ligand 1 (PD-L1), normally present in neural tissue, exists in close apposition to the mucosal immune system and intestinal epithelium, and a bi-directional communication is known to occur at these interfaces. Somatostatin has been shown to suppress the inflammatory reaction, and has been used in several clinical trials to treat inflammatory disorders, such rheumatoid arthritis. Read More

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December 2018

Is use of vitamin K antagonists associated with the risk of prostate cancer?: A meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13489

Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Background: Vitamin K antagonists (VKAs) may have potential antitumor effects in prostate cancer. However, the findings of observational studies are inconsistent. The purpose of the present study was to estimate the quantitative association between VKAs use and prostate cancer risk by combining the results of all eligible observational studies. Read More

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December 2018

Emergence of daptomycin non-susceptible coagulase-negative Staphylococci in patients with cardiovascular device infections: Two cases report investigated by whole genome analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13487

Division of Infection Control and Prevention, Osaka University Hospital.

Rationale: Daptomycin (DAP) is a key drug for treating severe Staphylococcus infections. The emergence of DAP non-susceptible Staphylococcus aureus has been widely recognized in clinical situations, although the clinical status of DAP non-susceptible coagulase-negative Staphylococcus (CoNS) infections is unclear. We encountered 2 cases of cardiovascular device infections that were associated with DAP non-susceptible CoNS. Read More

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December 2018

Clinical and prognostic analyses of 110 patients with N3 nasopharyngeal carcinoma.

Medicine (Baltimore) 2018 Dec;97(49):e13483

Department of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China.

Objective: To analyze the clinical outcome and prognostic factors of N3 nasopharyngeal carcinomas (NPCs), provide a basis for rational treatment and improve the cure rate.

Methods: A total of 110 patients with a pathologically confirmed diagnosis of N3 (NPC 2008 stage in China) NPC from our hospital were retrospectively included in the study conducted from April 2007 to July 2011. All patients received intensity-modulated radiation therapy. Read More

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December 2018
1 Read

Oral oxymatrine for hepatitis B cirrhosis: A systematic review protocol.

Medicine (Baltimore) 2018 Dec;97(49):e13482

Acupuncture and massage department, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Background: Characterized by diffuse hepatic fibrosis and nodule formation, hepatitis B cirrhosis (HBC), an important result of chronic hepatitis B development, mainly contains compensated and decompensated stage. Compensated cirrhosis can further develop into decompensated stage and hepatocellular carcinoma with serious complications and high mortality. Antiviral therapy using interferon (IFN) or nucleos(t)ide analogs (NUCs) is essential for improving the prognosis of the disease but IFN has large side effects while NUCs often develop drug resistance. Read More

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December 2018
1 Read

Dazhu Hongjingtian (Herba Rhodiolae) for unstable angina pectoris: Protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13481

Department of General Surgery, Nanjing Lishui District People's Hospital, Nanjing, Jiangsu, China.

Background: Dazhu Hongjingtian (DZHJT), also named Herba Rhodiolae, has been frequently introduced for patients with angina pectoris in China. However, the add-on effect of DZHJT in unstable angina pectoris (UAP) has not been systematically evaluated. The purpose of this protocol is to provide the methods used to assess the efficacy and safety of DZHJT as adjuvant therapy for management of UAP. Read More

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December 2018

The diagnostic role of miR-122 in drug-induced liver injury: A systematic review and meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13478

School of Graduates, Tianjin Medical University.

Background: Drug-induced liver injury (DILI) is a potentially severe adverse drug reaction especially in susceptible patients. But there are no sensitive or specific parameters to detecting DILI. The specific expression of miR-122 in the liver has been a hotspot in the evaluation of hepatic toxicity due to its high stability and sensitivity. Read More

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December 2018

Minimally invasive surgery for inflammatory myofibroblastic tumor of the urinary bladder: Three case reports.

Medicine (Baltimore) 2018 Dec;97(49):e13474

Department of Urology, Institute of Urology, West China Hospital, Sichuan University.

Rationale: Inflammatory myofibroblastic tumors of the urinary bladder (IMTUB) is exceptionally rare. Currently, no standardized treatment has been established for IMTUBs.

Patient Concerns: Herein we report three cases presenting with hematuria and anemia. Read More

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December 2018