145,582 results match your criteria Medicina intensiva / Sociedad Espanola de Medicina Intensiva y Unidades Coronarias[Journal]


Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1.

Nucleic Acids Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

Ataxia telangiectasia mutated and Rad3-related (ATR) kinase is a key factor activated by DNA damage and replication stress. An alternative pathway for ATR activation has been proposed to occur via stalled RNA polymerase II (RNAPII). However, how RNAPII might signal to activate ATR remains unknown. Read More

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December 2018

Detection of IgG1 against rK39 improves monitoring of treatment outcome in visceral leishmaniasis.

Clin Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Faculty of Medicine, University of Khartoum, Sudan.

Background: Visceral leishmaniasis (VL), caused by the Leishmania donovani complex, is a fatal neglected tropical disease that is targeted for elimination in India, Nepal and Bangladesh. Improved diagnostic tests are required for early case detection and for monitoring outcome of treatment. Previous investigations using Leishmania lysate antigen demonstrated that IgG1 response is a potential indicator of clinical status after chemotherapy. Read More

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December 2018

Galectin-8 Favors the Presentation of Surface-Tethered Antigens by Stabilizing the B Cell Immune Synapse.

Cell Rep 2018 Dec;25(11):3110-3122.e6

Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Católica de Chile, Region Metropolitana, Santiago 8331150, Chile. Electronic address:

Complete activation of B cells relies on their capacity to extract tethered antigens from immune synapses by either exerting mechanical forces or promoting their proteolytic degradation through lysosome secretion. Whether antigen extraction can also be tuned by local cues originating from the lymphoid microenvironment has not been investigated. We here show that the expression of Galectin-8-a glycan-binding protein found in the extracellular milieu, which regulates interactions between cells and matrix proteins-is increased within lymph nodes under inflammatory conditions where it enhances B cell arrest phases upon antigen recognition in vivo and promotes synapse formation during BCR recognition of immobilized antigens. Read More

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December 2018
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[Good practices and ethical principles: as necessary as ever].

Authors:
Lely Solari

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):306-309

Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas. Lima, Perú.

We are going through a moment in which acts of disregard to the ethics in the public function are being disclosed at all levels. It is important to know the codes of ethics and good practices of each of the functions performed. In the field of scientific publications, it is highly recommended that all researchers who wish to publish their studies get to know the good scientific practices and the basic ethical principles of publications in science. Read More

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December 2018

[Vibrio cholerae NO-O1/NO-O139 bacteremia in a cirrhotic patient. First case report in Peru and literatura review].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):301-305

Servicio de Enfermedades Infecciosas y Tropicales, Hospital Nacional Dos de Mayo. Lima, Perú; Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Lima, Perú.

Non-O1, non-O139 Vibrio cholerae (NOVC) strains are an uncommon cause of gastroenteritis. However, they have been recently associated with severe extraintestinal infections in immunocompromised hosts. Among them, bacteremia in cirrhotic patients is noteworthy. Read More

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December 2018

[Primary gastric choriocarcinoma: case report].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):297-300

Hospital Guillermo Kaelin de la Fuente. Lima, Perú; Universidad San Ignacio de Loyola, Lima, Perú.

Primary gastric choriocarcinoma (PGC) is an extremely rare and highly invasive tumor with rapid hematogenous spread. We present the case of a 57-year-old female patient who started with hematemesis and progressive episodes of melena, weight loss and epigastralgia. It is derived from the National Institute of Neoplastic Diseases where gastroscopy and biopsy are performed. Read More

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December 2018
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[Neoendocrine carcinoma of the esophagus: report of a case].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):293-296

Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas. Lima, Perú; Departamento de Medicina Interna, Hospital Nacional Hipólito Unanue. Lima, Perú.

Neuroendocrine carcinoma of esophagus represents less than 2% of cases of cancer of the esophagus. This presentation is extremely unusual, as this type of carcinoma typically presents with greater frequency in bronchopulmonary regions. The symptoms are usually associated with esophageal obstruction and include odynophagia, dysphagia and weight loss and are not usually associated with Carcinoid syndrome. Read More

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December 2018

[Fulminating ischemic hepatitis induced by severe cardiac dysfunction: case report].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):285-288

Facultad de Medicina, Universidad Peruana Cayetano Heredia. Lima, Perú.

Ischemic Hepatitis is an uncommon entity in daily clinical practice with a prevalence of 0.16 to 0.5% among patients admitted to a critical care unit, associated with an approximate 60% mortality rate. Read More

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December 2018
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[Cavernoma complicated with biliopatia secondary to type 1 Gaucher disease: report of a Peruvian case].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):280-284

Facultad de Medicina Humana, Universidad Nacional San Luis Gonzaga. Ica, Perú; Sociedad Científica de Estudiantes de Medicina de Ica (SOCEMI). Ica, Perú.

Gaucher disease is an autosomal recessive lysosomal storage disorder characterized by deficiency of beta-glucosidase that would lead to the accumulation of glucosylceramide mainly in cells of the mononuclear phagocytic system causing systemic effectations. We present a patient of twenty years who is suffering from chronic pain in the left hypochondrium with episodes of bleeding for 3 years and sensation of thermal rise, physical examination revealed jaundice and massive splenomegaly, without neurological involvement. Severe osteoporosis, pancytopenia, and the presence of portal vein thrombosis with cavernomatous transformation complicated by portal biliopathy simulating a klatskin tumor, marrow and enzymatic studies were compatible with Gaucher disease, were shown as unexpected findings. Read More

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December 2018

[Lynch syndrome: genetic, clinical and diagnostic aspects].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):265-279

Laboratorio de Genética Humana, Universidad Nacional Mayor de San Marcos. Lima, Perú; Laboratorio de Biología Molecular, Laboratorio Clínico Roe. Lima, Perú.

This review aims to present the genetic, clinical and diagnostic aspects of Lynch syndrome, as well as providing the most relevant information about genetic counseling in these patients and the current recommendations for their surveillance. Read More

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December 2018

[Gastric polyps: experience in Daniel Alcides Carrion Hospital 2014-2016].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):248-252

Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas. Lima, Perú; Servicio de Gastroenterología, Hospital Daniel Alcidez Carrión. Callao, Perú.

Objective: The purpose of this study was to determine the prevalence of the different types of gastric polyps in the Daniel Alcides Carrión Hospital between the years of 2014 and 2016, and also define the endoscopic and histopathological characteristics of the lesions.

Materials And Methods: 7559 endoscopic reports were reviewed, in which 148 gastric polyps were found. The patients age and sex as well as the localization, number, size and macroscopic and microscopic aspects of the polyps were recorded. Read More

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December 2018

Gene-function studies in SLE.

Curr Opin Rheumatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.

Purpose Of Review: The aim of this review is to discuss recent developments in our understanding of how systemic lupus erythematosus (SLE)-associated genes contribute to autoimmunity.

Recent Findings: Gene-function studies have revealed mechanisms through which SLE-associated alleles of IFIH1, TNFAIP3, IRF5, and PRDM1 likely contribute to the development of autoimmunity. Novel research has identified Mac-1 (encoded by ITGAM), CaMK4, and iRhom2 as plausible therapeutic targets in lupus nephritis. Read More

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December 2018
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Autophagy and intermittent fasting: the connection for cancer therapy?

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e814s. Epub 2018 Dec 10.

Departamento de Farmacologia, Escola Paulista de Medicina, Universidade Federal de Sao Paulo (EPM-UNIFESP), Sao Paulo, SP, BR.

Cancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to healthy cells. Thus, novel therapeutic strategies to improve chemotherapy, radiotherapy and targeted therapy are an important goal in cancer research. Read More

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December 2018

Primary malignant tumors of the adrenal glands.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e756s. Epub 2018 Dec 10.

Unidade de Suprarrenal, Laboratorio de Hormonios e Genetica Molecular LIM/42, Servico de Endocrinologia e Metabologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Malignancy must be considered in the management of adrenal lesions, including those incidentally identified on imaging studies. Adrenocortical carcinomas (ACCs) are rare tumors with an estimated annual incidence of 0.7-2 cases per year and a worldwide prevalence of 4-12 cases per million/year. Read More

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December 2018

Radiotherapy and immune response: the systemic effects of a local treatment.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e557s. Epub 2018 Dec 10.

Departamento de Radiologia e Oncologia, Divisao de Radioterapia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Technological developments have allowed improvements in radiotherapy delivery, with higher precision and better sparing of normal tissue. For many years, it has been well known that ionizing radiation has not only local action but also systemic effects by triggering many molecular signaling pathways. There is still a lack of knowledge of this issue. Read More

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December 2018

New method of sentinel lymph node biopsy in transoral robotic surgery for oropharyngeal squamous cell carcinoma.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e550s. Epub 2018 Dec 10.

Cirurgia de Cabeca e Pescoco, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SP, BR.

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December 2018
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Oxidative stress: therapeutic approaches for cervical cancer treatment.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e548s. Epub 2018 Dec 10.

Instituto do Cancer do Estado de Sao Paulo ICESP, Centro de Investigacao Translacional em Oncologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Objectives: Oxidative stress results from an imbalance between the generation and elimination of oxidant species. This condition may result in DNA, RNA and protein damage, leading to the accumulation of genetic alterations that can favor malignant transformation. Persistent infection with high-risk human papillomavirus types is associated with inflammatory responses and reactive oxygen species production. Read More

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December 2018
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Surgical treatment of gastric cancer: a 10-year experience in a high-volume university hospital.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e543s. Epub 2018 Dec 10.

Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Objectives: Surgery remains the cornerstone treatment modality for gastric cancer, the fifth most common type of tumor in Brazil. The aim of this study was to analyze the surgical treatment outcomes of patients with gastric cancer who were referred to a high-volume university hospital.

Methods: We reviewed all consecutive patients who underwent any surgical procedure due to gastric cancer from a prospectively collected database. Read More

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December 2018

Value-based medicine in oncology: the importance of perspective in the emerging value frameworks.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e470s. Epub 2018 Dec 10.

Centro de Investigacao Translacional em Oncologia, Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Recently, professional and healthcare-related entities have launched frameworks designed to assess the value of cancer innovations in multistakeholder decision processes. Among the most visible entities that propose and implement value frameworks in oncology are the European Society of Medical Oncology (ESMO), the American Society of Clinical Oncology (ASCO), the Memorial Sloan Kettering Cancer Center (MSKCC) and the National Comprehensive Cancer Network (NCCN). However, these value frameworks have been criticized for conceptual inconsistencies, inability to include a greater variety of value criteria, and inadequate explanation of the uncertainty approach used in the modeling process. Read More

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December 2018

Current concepts in multiparametric magnetic resonance imaging for active surveillance of prostate cancer.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e464s. Epub 2018 Dec 10.

Grupo de Uro-Oncologia, Departamento de Urologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR.

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December 2018

Detection molecular of Rangelia vitalii in dogs from Parana State, Southern Brazil.

Rev Bras Parasitol Vet 2018 Dec 10. Epub 2018 Dec 10.

Programa de Pós-graduação em Ciências Veterinárias, Universidade Federal do Paraná - UFPR, Curitiba, PR, Brasil.

Rangelia vitalii infects erythrocytes, leukocytes and endothelial cells of dogs. The present study aimed to report the molecular detection confirmed by sequencing of R. vitalii in the state of Paraná, as well as describe the clinical, hematological and biochemical alterations of the infected dogs. Read More

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December 2018

Neobenedenia melleni (Monogenea: Capsalidae) in ornamental reef fish imported to Brazil.

Rev Bras Parasitol Vet 2018 Dec 10. Epub 2018 Dec 10.

Laboratório AQUOS - Sanidade de Organismos Aquáticos, Departamento de Aquicultura, Universidade Federal de Santa Catarina - UFSC, Florianópolis, SC, Brasil.

The capsalid monogenean Neobenedenia melleni is known as a lethal pathogen for captured marine teleost ornamental fish, if left untreated. This study reports the occurrence of N. melleni parasitizing four species of ornamental reef fish imported into Brazil and maintained in quarantine: Arabian angelfish (Pomacanthus asfur ), yellowbar angelfish (Pomacanthus maculosus), regal angelfish (Pygoplites diacanthus), and bluecheek butterflyfish (Chaetodon semilarvatus). Read More

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December 2018

Micronutrient deficiencies following bariatric surgery: a comparative analysis between sleeve gastrectomy and Roux-en-Y gastric bypass.

Rev Col Bras Cir 2018 Dec 10;45(6):e2016. Epub 2018 Dec 10.

Universidade Federal de Pernambuco, Departamento de Cirurgia, Recife, PE, Brasil.

Objective: to compare the prevalence of micronutrient deficiencies in patients submitted to sleeve gastrectomy (SG) and Roux- en-Y gastric bypass (RYGB).

Methods: this is a comparative study of 576 patients submitted to bariatric surgery, 338 to SG and 238 to RYGB, and evaluated for hemoglobin, iron, ferritin, zinc and vitamin B12 serum levels. We performed these dosages in the preoperative period and at three, six, 12 and 24 months after surgery, for analysis and comparison of micronutrient deficiencies among the techniques. Read More

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December 2018

Analysis of the lipid profile of patients submitted to sleeve gastrectomy and Roux-en-Y gastric bypass.

Rev Col Bras Cir 2018 Dec 10;45(6):e1967. Epub 2018 Dec 10.

Universidade Federal de Pernambuco, Programa de Pós-Graduação em Cirurgia, Recife, PE, Brasil.

Objective: to compare the improvements in lipid profile in patients undergoing sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB).

Methods: in a mixed cohort study, we evaluated 334 patients undergoing SG and 178 patients undergoing RYGB at the University Hospital of the Federal University of Pernambuco and at the Real Hospital Português de Beneficência, Recife, PE, Brazil. We measured serum levels of total cholesterol, LDL, HDL and triglycerides preoperatively and at three, six, 12 and 24 months follow-up. Read More

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December 2018

RECOMMENDATIONS OF THE BRAZILIAN SOCIETY OF HEPATOLOGY FOR THE MANAGEMENT OF ACUTE KIDNEY INJURY IN PATIENTS WITH CIRRHOSIS.

Arq Gastroenterol 2018 Jul-Sep;55(3):314-320

Hospital Português, Unidade de Gastroenterologia e Hepatologia, Salvador, BA, Brasil.

Acute kidney injury is a common complication of cirrhosis, occurring in up to 20% of patients hospitalized with cirrhosis. This field is rapidly changing, with significant advances in classification, biomarkers and therapy over the last few years. On the behalf of the Brazilian Society of Hepatology, a panel of experts in Hepatology and Nephrology reviewed published evidence to integrate findings and develop the recommendations presented in this manuscript. Read More

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THE EFFICACY OF THE DIFFERENT ENDOSCOPIC TREATMENTS VERSUS SHAM, PHARMACOLOGIC OR SURGICAL METHODS FOR CHRONIC GASTROESOPHAGEAL REFLUX DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Arq Gastroenterol 2018 Jul-Sep;55(3):296-305

Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Departamento de Endoscopia Avançada Gastrointestinal, São Paulo, SP, Brasil.

Background: Endoscopic antireflux treatments for gastroesophageal reflux disease (GERD) are still evolving, and most of the published studies address symptom relief in the short-term. Objective - We aimed to perform a systematic review and meta-analysis focused on evaluating the efficacy of the different endoscopic procedures.

Methods: Search was restricted to randomized controlled trials (RCTs) on MedLine, Cochrane, SciELO, and EMBASE for patients with chronic GERD (>6 months), over 18 years old and available follow up of at least 3 months. Read More

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THE ONSET OF CLINICAL MANIFESTATIONS IN INFLAMMATORY BOWEL DISEASE PATIENTS.

Arq Gastroenterol 2018 Jul-Sep;55(3):290-295

Universidade do Estado da Bahia, Departamento de Ciências da Vida, Salvador, BA, Brasil.

Background: The diagnosis of inflammatory bowel disease is often delayed because of the lack of an ability to recognize its major clinical manifestations.

Objective: Our study aimed to describe the onset of clinical manifestations in inflammatory bowel disease patients.

Methods: A cross-sectional study. Read More

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October 2017

TARGET, PRESCRIPTION AND INFUSION OF ENTERAL NUTRITIONAL THERAPY OF CRITICAL PATIENTS IN INTENSIVE CARE UNIT.

Arq Gastroenterol 2018 Jul-Sep;55(3):283-289

PUC, Programa de Pós-Graduação em Ciências da Saúde, Grupo de Pesquisa: Diagnóstico e Terapia Clínica e Cirúrgica, Campinas, SP, Brasil.

Background: Enteral nutritional therapy (ENT) is the best route for the nutrition of critically ill patients with improved impact on the clinical treatment of such patients.

Objective: To investigate the energy and protein supply of ENT in critically ill in-patients of an Intensive Care Unit (ICU).

Methods: Prospective longitudinal study conducted with 82 critically ill in-patients of an ICU, receiving ENT. Read More

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INSULIN RESISTANCE REDUCTION AFTER SUSTAINED VIROLOGICAL RESPONSE WITH DIRECT ACTING ANTIVIRAL:NOT EVERY POPULATION IMPROVES.

Arq Gastroenterol 2018 Jul-Sep;55(3):274-278

Universidade Estadual Paulista (UNESP), Faculdade de Medicina, Departamento de Clínica Médica, Botucatu, SP, Brasil.

Background: Hepatitis C virus (HCV) infection is a serious public health problem, that affects approximately 170 million people worldwide. Chronic HCV infection is associated with hepatic insulin resistance and an increased risk of diabetes HCV-infected patients has been well documented.

Objective: To assess the homeostasis model assessment of insulin resistance (HOMA-IR) index in patients treated with direct acting antiviral (DAAs) medication in the sustained virological response (SVR), categorized by the presence or absence of cirrhosis. Read More

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HEPATITIS B AND C IN PREGNANT WOMEN ATTENDED BY A PRENATAL PROGRAM IN AN UNIVERSITARY HOSPITAL IN RIO DE JANEIRO, BRAZIL: RETROSPECTIVE STUDY OF SEROPREVALENCE SCREENING.

Arq Gastroenterol 2018 Jul-Sep;55(3):267-273

Universidade Federal Fluminense, Faculdade de Medicina, Departamento de Medicina Interna, Rio de Janeiro, RJ, Brasil.

Background: Hepatitis B and C are diseases with high morbimortality and constitute a global public health problem. In Brazil, the prevalence is not homogeneous, oscillating among different regions, but it is estimated that currently about 1% of the population present chronic disease related to the B virus and that there are 1.5 million infected with the C virus. Read More

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METACHRONOUS COLORECTAL LIVER METASTASES HAS BETTER PROGNOSIS - IS IT TRUE?

Arq Gastroenterol 2018 Jul-Sep;55(3):258-263

Universidade Federal de Goiás, Faculdade de Medicina, Hospital das Clínicas, Departamento de Cirurgia, Goiânia, GO, Brasil.

Background: Liver metastases from colorectal cancer are an important public health problem due to the increasing incidence of colorectal cancer worldwide. Synchronous colorectal liver metastasis has been associated with worse survival, but this prognosis is controversial.

Objective: The objective of this study was to evaluate the recurrence-free survival and overall survival between groups of patients with metachronous and synchronous colorectal hepatic metastasis. Read More

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February 2018
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ANALYSIS OF RISK FACTORS AND POSTOPERATIVE COMPLICATIONS IN PATIENTS WITH CROHN'S DISEASE.

Arq Gastroenterol 2018 Jul-Sep;55(3):252-257

Universidade Estadual Paulista (UNESP), Faculdade de Medicina, Departamento de Cirurgia e Ortopedia, Botucatu, SP, Brasil.

Background: The post-operative complications rate is greater in patients with Crohn's disease than in other abdominal surgeries due to other benign conditions. Prevention and management of such complications are important factors in the care of these patients.

Objective: The objectives of this research are to analyze the rate of postoperative complications and the major risk factors in patients with Crohn's disease. Read More

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February 2018

IMPACT OF SMALL BOWEL CAPSULE ENDOSCOPY IN IRON DEFICIENCY ANEMIA: INFLUENCE OF PATIENT'SAGE ON DIAGNOSTIC YIELD.

Arq Gastroenterol 2018 Jul-Sep;55(3):242-246

Hospital Senhora da Oliveira, Departamento de Gastroenterologia, Guimarães, Portugal.

Background: Iron deficiency anemia remains one of the main indications to perform small bowel capsule endoscopy. Literature suggests that diagnostic yield is influenced by patient's age but with conflicting results regarding age cutoff.

Objective: We aimed to clarify the differences in diagnostic yield and incidence of specific findings according to age. Read More

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February 2018

USEFULNESS OF GASTRIC SUBMUCOSAL DISSECTION DEPTH TO EVALUATE SKILL ACQUIREMENT IN SHORT TERM TRAINING COURSES IN ESD: AN EXPERIMENTAL STUDY.

Arq Gastroenterol 2018 Jul-Sep;55(3):221-229

Universidade de São Paulo, Faculdade de Medicina, Departamento de Endoscopia Gastrointestinal, SP, Brasil.

Background: Endoscopic submucosal dissection (ESD) is a complex endoscopic procedure, with high rates of adverse events and technical difficulties. To overcome that problem, many training centers published the importance of animal models for skill acquirement in ESD. However, no study has used the submucosal dissection depth (DSUB) as a parameter to evaluate the learning curve in ESD, which might be a relevant factor since an optimal resection plane is important to achieve a curative resection and avoid intraoperative complications. Read More

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February 2018

US-GUIDED PERCUTANEOUS CORE LIVER BIOPSY: ANALYSIS OF 171 CASES FROM A SINGLE ONCOLOGY SERVICE.

Arq Gastroenterol 2018 Jul-Sep;55(3):208-211

Universidade Estadual do Ceará (UECE), Faculdade de Medicina, Fortaleza, CE, Brasil.

Background: Though strongly suggestive of metastasis, focal lesions on liver scans of oncological patients require histological confirmation for the prescription of adequate treatment.

Objective: To evaluate the safety and efficacy of US-guided percutaneous core liver biopsy.

Methods: Descriptive, cross-sectional study based on secondary data from 171 patients submitted to US-guided percutaneous core liver biopsy at the diagnostic radiology service of the Ceará Cancer Institute (ICC, Brazil) between February 2010 and March 2015. Read More

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December 2017
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INFLAMMATORY BOWEL DISEASE: IMPACT ON SCORES OF QUALITY OF LIFE, DEPRESSION AND ANXIETY IN PATIENTS ATTENDING A TERTIARY CARE CENTER IN BRAZIL.

Arq Gastroenterol 2018 Jul-Sep;55(3):202-207

Programa de Pós-Graduação: Ciências da Gastroenterologia e Hepatologia, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.

Background: Inflammatory bowel disease frequently affects patients at working age, compromising their quality of life in several levels: physical, psychological, familial and social. Few studies have evaluated the impact of Inflammatory bowel disease on quality of life, anxiety and depression in Brazilian patients.

Objective: Evaluate quality of life and its correlation with psychological aspects of patients with inflammatory bowel disease through the Inflammatory Bowel Disease Questionnaire and Hospital Anxiety and Depression Scale. Read More

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November 2017

Characterisation of plasmid-mediated rmtB-1 in Enterobacteriaceae clinical isolates from São Paulo, Brazil.

Mem Inst Oswaldo Cruz 2018 Dec 10;113(12):e180392. Epub 2018 Dec 10.

Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Medicina Interna, Divisão de Doenças Infecciosas, Laboratório Alerta, São Paulo, SP, Brasil.

OBJECTIVES The emergence of 16S rRNA methyltranferases (16 RMTAses) has jeopardised the clinical use of aminoglycosides. RmtB is one of the most frequently reported in Gram-negatives worldwide. In this study, we aimed to estimate the frequency of 16S RMTAses encoding genes in Enterobacteriaceae isolated in a three-month period from a tertiary Brazilian hospital. Read More

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December 2018

Polymorphisms in the TGFB1 and IL2RA genes are associated with clinical forms of leprosy in Brazilian population.

Mem Inst Oswaldo Cruz 2018 Dec 10;113(12):e180274. Epub 2018 Dec 10.

Instituto Lauro de Souza Lima, Bauru, SP, Brasil.

BACKGROUND Leprosy is a chronic infectious disease caused by Mycobacterium leprae, and compromises the skin and peripheral nerves. This disease has been classified as multibacillary (MB) or paucibacillary (PB) depending on the host immune response. Genetic epidemiology studies in leprosy have shown the influence of human genetic components on the disease outcomes. Read More

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December 2018
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Effect of fluoride application during radiotherapy on enamel demineralization.

J Appl Oral Sci 2018 Dec 10;27:e20180044. Epub 2018 Dec 10.

Universidade Federal de Uberlândia, Faculdade de Odontologia, Departamento de Dentística e Materiais Odontológicos, Uberlândia, Minas Gerais, Brasil.

Objective: Radiation-related caries are one the most undesired reactions manifested during or after head and neck radiotherapy. Fluoride application is an important strategy to reduce demineralization and enhance remineralizaton. To evaluate the effect of the topical application of fluoride during irradiation on dental enamel demineralization. Read More

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December 2018

Assessment of the product of nursing care in specialized hospitals.

Rev Bras Enferm 2018 ;71(suppl 6):2675-2681

Faculdade de Medicina de São José do Rio Preto. São Jose do Rio Preto, São Paulo, Brazil.

Objective: To evaluate the product of care in units of specialized hospitals, identifying the items that most contributed to the score; to compare the product of care among hospitals, units, and shifts; to verify the association between demographic and professionals variables and the product of care.

Method: Descriptive study, conducted in eight units of two specialized hospitals in the State of São Paulo. The evaluation of the product of care was performed by applying an instrument to 44 nurses. Read More

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January 2018

Importance of cerebrospinal fluid investigation during dengue infection in Brazilian Amazonia Region.

Mem Inst Oswaldo Cruz 2018 Dec 10;114:e180450. Epub 2018 Dec 10.

Universidade Federal do Estado do Rio de Janeiro/Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

BACKGROUND Amazon, the largest tropical forest of the world, has suffered from dengue outbreaks since 1998. Cerebrospinal fluid (CSF) of patients, from Amazonas state, suspected of central nervous system (CNS) viral infection was studied using molecular and immunological methods. OBJECTIVE To evaluate the importance of CSF investigation in patients with acute dengue virus (DENV) infection of CNS. Read More

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December 2018

Brazilian guidelines for the management of psychomotor agitation. Part 1. Non-pharmacological approach.

Braz J Psychiatr 2018 Dec 6. Epub 2018 Dec 6.

Comissão de Emergências Psiquiátricas, Associação Brasileira de Psiquiatria (ABP), Rio de Janeiro, RJ, Brazil.

Objective: To present the essential guidelines for non-pharmacological management of patients with psychomotor agitation in Brazil.

Methods: These guidelines were developed based on a systematic review of articles published from 1997 to 2017, retrieved from MEDLINE (PubMed), Cochrane Database of Systematic Review, and SciELO. Other relevant articles identified by searching the reference lists of included studies were also used to develop these guidelines. Read More

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December 2018

No evidence of attentional bias toward angry faces in patients with obsessive-compulsive disorder.

Braz J Psychiatr 2018 Dec 6. Epub 2018 Dec 6.

Departamento e Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.

Objective: Although attentional bias (AB) toward angry faces is well established in patients with anxiety disorders, it is still poorly studied in obsessive-compulsive disorder (OCD). We investigated whether OCD patients present AB toward angry faces, whether AB is related to symptom severity and whether AB scores are associated with specific OCD symptom dimensions.

Method: Forty-eight OCD patients were assessed in clinical evaluations, intelligence testing and a dot-probe AB paradigm that used neutral and angry faces as stimuli. Read More

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December 2018

Topography of 11C-Pittsburgh compound B uptake in Alzheimer's disease: a voxel-based investigation of cortical and white matter regions.

Braz J Psychiatr 2018 Dec 6. Epub 2018 Dec 6.

Núcleo de Apoio à Pesquisa em Neurociência Aplicada (NAPNA), USP, São Paulo, SP, Brazil.

Objective: To compare results of positron emission tomography (PET) with carbon-11-labeled Pittsburgh compound B (11C-PIB) obtained with cerebellar or global brain uptake for voxel intensity normalization, describe the cortical sites with highest tracer uptake in subjects with mild Alzheimer's disease (AD), and explore possible group differences in 11C-PIB binding to white matter.

Methods: 11C-PIB PET scans were acquired from subjects with AD (n=17) and healthy elderly controls (n=19). Voxel-based analysis was performed with statistical parametric mapping (SPM). Read More

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December 2018

Molecular typing reveals the co-existence of two transmission cycles of American cutaneous leishmaniasis in the Andean Region of Venezuela with Lutzomyia migonei as the vector.

Mem Inst Oswaldo Cruz 2018 Dec 6;113(12):e180323. Epub 2018 Dec 6.

Universidad de Carabobo, Facultad de Ciencias de la Salud, Centro Nacional de Referencia de Flebotomos y otros Vectores, Instituto de Investigaciones Biomédicas Dr Francisco J Triana-Alonso, Maracay, Venezuela.

BACKGROUND The transmission routes for American cutaneous leishmaniasis (ACL) are in flux, so studies examining its transmission in humans, mammalian hosts, and sand fly vectors are urgently needed. OBJECTIVES The aim of this work was understand the epidemiological cycles of Leishmania spp., which causes ACL in the Andean Region of Venezuela, by identifying the Leishmania and the sand fly species involved in human and dog infections. Read More

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December 2018

[Validation of the Oral Impacts on Daily Performance index among the Portuguese population].

Cien Saude Colet 2018 Dec;23(12):4351-4360

Faculdade de Medicina Dentária, Universidade de Lisboa. R. Professora Teresa Ambrósio, Cidade Universitária. 1600-177 Lisboa

The Oral Impacts on Daily Performance (OIDP) questionnaire is an oral health-related quality of life indicator. It was developed in order to assess the influence of oral conditions on the self-ability to execute daily activities. The main goal of this research was to validate the OIDP for the Portuguese population aged 18 years and above. Read More

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December 2018

Education-service integration in the context of Brazilian medical schools: an integrative review.

Cien Saude Colet 2018 Dec;23(12):4241-4248

Escola Paulista de Medicina, Universidade Federal de São Paulo. Santos SP Brasil.

This paper aimed to characterize the historical trajectory, including the advances and challenges, of the teaching-service integration in the medical training process. In this context, through scientific studies indexed in databases, a critical review of the literature was performed from the search for works of reference until the present moment. Most of the works consulted were reference material on the topic published in scientific journals and indexed in the databases of the Virtual Health Library. Read More

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December 2018

[Leisure among university students in the healthcare area: a review of the literature].

Cien Saude Colet 2018 Dec;23(12):4221-4229

Faculdade de Medicina, Universidade Estadual Paulista Julio de Mesquita Filho. Rubião Junior s/n, Rubião Junior. 18618-000 Botucatu SP Brasil.

This article set out to analyze studies on leisure activities among university students in the healthcare area. It conducted a search using the following key words: leisure and students, and their corresponding terms in Spanish and English in the Bireme database, which resulted in 32 articles at the end of the review. In the articles analyzed there was a predominance of the following leisure interests: sports, social, intellectual and artistic activities, with a greater number of articles presenting experiences in sports. Read More

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December 2018

Brazilian National School Food Program as a promoter of local, healthy and sustainable food systems: evaluating the financial implementation.

Cien Saude Colet 2018 Dec;23(12):4189-4197

Programa de Pós-Graduação em Nutrição, Departamento de Nutrição, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina. Florianópolis SC Brasil.

This study aimed to analyze the financial investment used for the procurement of food for the Brazilian National School Food Program (PNAE) in a city in the South of Brazil. The bidding process, the public calls and accountability reports of the PNAE were analyzed in the following variables: I) municipal financial complementation values; II) percentage of resources used to purchase foods from Family Farmer (FF), and Recommended, Restricted, Prohibited and others foods. The comparison of proportions was employed as a test to identify differences between investments. Read More

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December 2018

Lactose in processed foods: evaluating the availability of information regarding its amount.

Cien Saude Colet 2018 Dec;23(12):4119-4128

Curso de Nutrição e Metabolismo, Departamento de Ciências da Saúde, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo. Ribeirão Preto SP Brasil.

Patients with lactose intolerance, a high prevalence disease, should control the intake of food with lactose to avoid gastrointestinal symptoms. Since tolerance depends on the amount of lactose ingested, it is essential to discuss the availability of the amount of lactose information in processed foods, which is currently not mandatory. The study measured the availability of information on the amount of lactose on the labels of processed food that contained milk or lactose in the ingredient list. Read More

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December 2018
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