148,083 results match your criteria Medicina intensiva / Sociedad Espanola de Medicina Intensiva y Unidades Coronarias[Journal]


Endothelial dysfunction in pregnancy metabolic disorders.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 19. Epub 2019 Feb 19.

Departamento de Ciencias Biologicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, 8370146 Santiago, Chile; Millennium Institute on Immunology and Immunotherapy, 8331150 Santiago, Chile. Electronic address:

In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.009DOI Listing
February 2019

Ixodes ricinus infesting snakes: Insights on a new tick-host association in a Borrelia burgdorferi sensu lato endemic area.

Acta Trop 2019 Feb 19. Epub 2019 Feb 19.

Dipartimento di Medicina Veterinaria, Università degli Studi di Bari, 70010 Valenzano, Italy. Electronic address:

The castor bean tick Ixodes ricinus is one of the most abundant tick species in Europe, being able to parasitize a wide number of vertebrate hosts, including mammals, birds, and reptiles. This tick species has an important role as vector of zoonotic pathogens, including the causative agents of Lyme borreliosis (i.e. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.021DOI Listing
February 2019

The association of HLA-G polymorphisms and the synergistic effect of sMICA and sHLA-G with chronic kidney disease and allograft acceptance.

PLoS One 2019 22;14(2):e0212750. Epub 2019 Feb 22.

Laboratório de Imunogenética e Histocompatibilidade, Departamento de Genética, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.

The HLA-G and MICA genes are stimulated under inflammatory conditions and code for soluble (sMICA and sHLA-G) or membrane-bound molecules that exhibit immunomodulatory properties. It is still unclear whether they would have a synergistic or antagonistic effect on the immunomodulation of the inflammatory response, such as in chronic kidney disease (CKD), contributing to a better prognosis after the kidney transplantation. In this study, we went from genetic to plasma analysis, first evaluating the polymorphism of MICA, NKG2D and HLA-G in a cohort from Southern Brazil, subdivided in a control group of individuals (n = 75), patients with CKD (n = 94), and kidney-transplant (KT) patients (n = 64). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212750PLOS
February 2019

Earlier relapse detection after allogeneic haematopoietic stem cell transplantation by chimerism assays: Digital PCR versus quantitative real-time PCR of insertion/deletion polymorphisms.

PLoS One 2019 22;14(2):e0212708. Epub 2019 Feb 22.

Haematology Department, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.

Background: The analysis of molecular haematopoietic chimerisms (HC) has become a well-established method to monitor the transplant evolution and to assess the risk of relapse after allogeneic stem cells transplantation (allo-STC). Different techniques and molecular markers are being used for chimerism surveillance after transplantation, including quantitative real-time PCR (qPCR) and the recently developed digital PCR (dPCR). This study aims to compare the sensitivity and accuracy of both methods to quantify HC and predict early relapse. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212708PLOS
February 2019

Pharmacokinetics of serotonergic drugs: focus on OCD.

Expert Opin Drug Metab Toxicol 2019 Feb 22. Epub 2019 Feb 22.

c Full Professor of Psychiatry, Director, Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry , University of Pisa , Italy.

Introduction: Although the treatment of obsessive-compulsive disorder (OCD), a common, chronic and disabling psychiatric condition, has significantly improved in the last decades, with the demonstration of the specific effectiveness of serotonin reuptake inhibitors (SRIs), a large proportion of patients still show high relapse rates. In addition, pharmacological treatments should be maintained for years, so that the clinicians should take into account the pharmacokinetic changes in the long-term, which may be responsible for dangerous side effects or interactions. Areas covered: The aim of this paper was to review the literature on pharmacokinetics of SSRIs and clomipramine, and on their pharmacokinetic parameters in OCD patients. Read More

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http://dx.doi.org/10.1080/17425255.2019.1584611DOI Listing
February 2019

Regional dynamics of the resting brain in amyotrophic lateral sclerosis using fALFF and ReHo analyses.

Brain Connect 2019 Feb 22. Epub 2019 Feb 22.

Universidade Federal do ABC, 74362, Santo Andre, SP, Brazil ;

Resting state functional magnetic resonance imaging (rs-fMRI) has been playing an important role in the study of amyotrophic lateral sclerosis (ALS). Although functional connectivity is widely studied, the patterns of spontaneous neural activity of the resting brain are important mechanisms that have been used recently to study a variety of conditions but remain less explored in ALS. Here we have used fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo) to study the regional dynamics of the resting brain of non-demented ALS patients compared with healthy controls. Read More

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http://dx.doi.org/10.1089/brain.2019.0663DOI Listing
February 2019

Low dose fluoroscopy during ureteroscopy does not compromise surgical outcomes.

J Endourol 2019 Feb 22. Epub 2019 Feb 22.

Hospital das Clínicas, University of Sao Paulo Medical School, Division of Urology , barata ribeiro street,490 room25 , São Paulo, São Paulo, Brazil , 01308001 ;

Objective: to evaluate if reducing the dose of fluoroscopy to ¼ of standard dose during unilateral ureteroscopy for ureteral stone treatment would impact in a reduction of total radiation emitted and if this strategy would impact in operation time, stone free rate and complication rate.

Methods: from August 2016 to August 2017, patients over 18 years old submitted to ureteroscopy for ureteral stone between 5-20 mm were prospectively randomized for ¼ dose reduction or standard dose fluoroscopy. Patients with abnormal urinary anatomy such as horseshoe kidney, pelvic kidney or duplex system were excluded from the study. Read More

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http://dx.doi.org/10.1089/end.2018.0722DOI Listing
February 2019

Comment on: Tofacitinib for familial Mediterranean fever: a new alternative therapy?: reply.

Rheumatology (Oxford) 2019 Feb 21. Epub 2019 Feb 21.

Grupo de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional, Fundación Valle Del Lili and Universidad Icesi, Cali, Colombia.

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http://dx.doi.org/10.1093/rheumatology/kez047DOI Listing
February 2019

spp. Infection Rate and Feeding Patterns of Sand Flies (Diptera: Psychodidae) from a Hyperendemic Cutaneous Leishmaniasis Community in Panamá.

Am J Trop Med Hyg 2019 Feb 18. Epub 2019 Feb 18.

Programa Centroamericano de Maestría en Entomología, Universidad de Panamá, Ciudad de Panamá, Panamá.

American cutaneous leishmaniasis (ACL) is a common and important vector-borne parasitic zoonosis in Panamá. Here, we study spp. infection rates and blood-feeding patterns among common sand flies in Trinidad de Las Minas, a rural community with hyperendemic ACL transmission, and where a deltamethrin fogging trial was performed. Read More

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http://dx.doi.org/10.4269/ajtmh.17-0628DOI Listing
February 2019

Policy strategies to reduce waiting times for elective surgery: A scoping review and evidence synthesis.

Int J Health Plann Manage 2019 Feb 22. Epub 2019 Feb 22.

Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago, Chile.

Objectives: The purpose of this evidence-based review is to identify and describe the interventions that have been implemented to reduce waiting times for major elective surgery.

Methods: Scoping review and presentation of the results according to the SUPPORT tools. We searched MEDLINE/PubMed, Embase, Cochrane Library, SciELO, DARE-HTA, and Google Scholar. Read More

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http://dx.doi.org/10.1002/hpm.2751DOI Listing
February 2019

First case of skin allergy to pregabalin with positive patch tests.

Contact Dermatitis 2019 Feb 21. Epub 2019 Feb 21.

Allergy Section, Hospital General Universitario., Ciudad Real, Spain.

A 51-year-old female patient was treated with Pregabalin (Lyrica) 25 mg/day for 3 weeks and 75 mg/day during a 4th week). After a month of treatment, a maculopular rash developed in the nape, neck, ears, arms knees and ankles which improved after the withdrawal of the drug and administration of deflazacort 30 mg for 5 days. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/cod.13249DOI Listing
February 2019

Disassembly of the synaptonemal complex in chicken oocytes analyzed by super-resolution microscopy.

Chromosoma 2019 Feb 22. Epub 2019 Feb 22.

Department of Cell and Developmental Biology, Biocenter, University of Würzburg, 97074, Würzburg, Germany.

The synaptonemal complex is an evolutionarily conserved, supramolecular structure that holds the homologous chromosomes together during the pachytene stage of the first meiotic prophase. Among vertebrates, synaptonemal complex dynamics has been analyzed in mouse spermatocytes following the assembly of its components from leptotene to pachytene stages. With few exceptions, a detailed study of the disassembly of SCs and the behavior of SC components at recombination sites at the onset of diplotene has not been accomplished. Read More

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http://dx.doi.org/10.1007/s00412-019-00693-wDOI Listing
February 2019

Mobilizing hematopoietic progenitor cells in donors with sickle cell trait is safe.

Hematol Transfus Cell Ther 2019 Jan-Mar;41(1):101-102. Epub 2018 May 25.

Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP USP), Ribeirão Preto, SP, Brazil.

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http://dx.doi.org/10.1016/j.htct.2018.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371198PMC

Atypical herpes vasculitis in a leukemic patient: An unusual presentation.

Hematol Transfus Cell Ther 2019 Jan-Mar;41(1):95-98. Epub 2018 Aug 7.

Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (HC FMUSP), São Paulo, SP, Brazil.

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http://dx.doi.org/10.1016/j.htct.2018.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371409PMC

Current role of interferon in hairy cell leukemia therapy: a timely decision.

Hematol Transfus Cell Ther 2019 Jan-Mar;41(1):88-90. Epub 2018 Jun 11.

Instituto do Câncer do Estado de São Paulo (ICESP), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil.

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http://dx.doi.org/10.1016/j.htct.2018.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371201PMC

Female genital tract chronic graft-versus-host disease: A narrative review.

Hematol Transfus Cell Ther 2019 Jan-Mar;41(1):69-75. Epub 2018 Jul 29.

Fundação Doutor Amaral Carvalho, Jaú, SP, Brazil.

Graft-versus-host disease is one of the main causes of morbidity and mortality in patients submitted to hematopoietic stem cell transplantation. This study reviewed the prevalence of lower female genital tract graft-versus-host disease following hematopoietic stem cell transplantation. A systematic search of the literature for articles published between 1982 and 2015 was performed. Read More

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http://dx.doi.org/10.1016/j.htct.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371232PMC

Revisiting the complete blood count and clinical findings at diagnosis of childhood acute lymphoblastic leukemia: 10-year experience at a single center.

Hematol Transfus Cell Ther 2019 Jan-Mar;41(1):57-61. Epub 2018 Jul 27.

Facultad de Medicina y Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, Mexico.

Background: Heterogeneity regarding clinical and laboratory findings at diagnosis of acute lymphoblastic leukemia exists. The frequency of complete blood count abnormalities and its combinations, symptoms and physical findings were investigated in Hispanic children from an open population at the diagnosis of acute lymphoblastic leukemia.

Methods: The patient charts and electronic records of under 16-year-old children diagnosed with acute lymphoblastic leukemia over 10 years at a regional hematology center of a university hospital were analyzed to retrieve data concerning the complete blood count at first evaluation. Read More

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http://dx.doi.org/10.1016/j.htct.2018.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371227PMC

Barriers in Latin America for the management of locally advanced breast cancer.

Ecancermedicalscience 2019 22;13:897. Epub 2019 Jan 22.

Departamento de Medicina Oncológica, Oncosalud-AUNA, Lima 15036, Peru.

Breast cancer (BC) is a highly prevalent malignancy in Latin American women, most cases being diagnosed at locally advanced or metastatic stages when options for cancer care are limited. Despite its label as a public health problem in the region, Latin American BC patients face several barriers in accessing standard of care treatment when compared with patients from developed countries. In this review, we analyse the landscape of the four main identified barriers in the region: i) high burden of locally advanced/advanced BC; ii) inadequate access to medical resources; iii) deficient access to specialised cancer care and iv) insufficient BC research in Latin America. Read More

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http://dx.doi.org/10.3332/ecancer.2019.897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372299PMC
January 2019

Precision medicine for locally advanced breast cancer: frontiers and challenges in Latin America.

Ecancermedicalscience 2019 22;13:896. Epub 2019 Jan 22.

Departamento de Medicina Oncológica, Oncosalud-AUNA, Lima 15036, Perú.

Advances in high-throughput technologies and their involvement in the 'omics' of cancer have made possible the identification of hundreds of biomarkers and the development of predictive and prognostic platforms that model the management of cancer from evidence-based medicine to precision medicine. Latin America (LATAM) is a region characterised by fragmented healthcare, high rates of poverty and disparities to access to a basic standard of care not only for cancer but also for other complex diseases. Patients from the public setting cannot afford targeted therapy, the facilities offering genomic platforms are scarce and the use of high-precision radiotherapy is limited to few facilities. Read More

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http://dx.doi.org/10.3332/ecancer.2019.896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372295PMC
January 2019

Conservative treatment for well-differentiated endometrial cancer: when and why it should be considered in young women.

Ecancermedicalscience 2019 16;13:892. Epub 2019 Jan 16.

Department of Surgical Sciences, Division of Gynecology and Obstetrics, University of Cagliari, 09124 Cagliari, Italy.

The aim of this review was to update current knowledge on the conservative treatment of endometrial cancer (EC) based on a literature review. A web-based search in the MEDLINE database was carried out on EC management and treatment. All relevant information has been collected and analysed. Read More

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http://dx.doi.org/10.3332/ecancer.2019.892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369973PMC
January 2019

Dynamic Effects of CYP2D6 Genetic Variants in a Set of Poor Metaboliser Patients with Infiltrating Ductal Cancer Under Treatment with Tamoxifen.

Sci Rep 2019 Feb 21;9(1):2521. Epub 2019 Feb 21.

Universidad Simón Bolivar, Facultad de Ciencias Básicas y Biomédicas, Laboratorio de Simulación Molecular y Bioinformática, Barranquilla, 080002, Colombia.

Breast cancer is a group of multigenic diseases. It is the most common cancer diagnosed among women worldwide and is often treated with tamoxifen. Tamoxifen is catalysed by cytochrome P450 2D6 (CYP2D6), and inter-individual variations in the enzyme due to single nucleotide polymorphisms (SNPs) could alter enzyme activity. Read More

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http://dx.doi.org/10.1038/s41598-018-38340-6DOI Listing
February 2019

Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1.

Sci Rep 2019 Feb 21;9(1):2504. Epub 2019 Feb 21.

Department of Pharmacy, University of Naples "Federico II", via D. Montesano 49, 80131, Naples, Italy.

The G-protein bile acid receptor 1 (GPBAR1) has emerged in the last decade as prominent target for the treatment of metabolic and inflammatory diseases including type 2 diabetes, obesity, and non-alcoholic steatohepatitis. To date numerous bile acid derivatives have been identified as GPBAR1 agonists, however their clinical application is hampered by the lack of selectivity toward the other bile acid receptors. Therefore, non-steroidal GPBAR1 ligands able to selectively activate the receptor are urgently needed. Read More

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http://dx.doi.org/10.1038/s41598-019-38840-zDOI Listing
February 2019

Reactive species and pathogen antioxidant networks during phagocytosis.

J Exp Med 2019 Feb 21. Epub 2019 Feb 21.

Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay

The generation of phagosomal cytotoxic reactive species (i.e., free radicals and oxidants) by activated macrophages and neutrophils is a crucial process for the control of intracellular pathogens. Read More

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http://dx.doi.org/10.1084/jem.20181886DOI Listing
February 2019

MT4-MMP Modulates the Expression of miRNAs in Breast Cancer Cells.

Arch Med Res 2019 Feb 18. Epub 2019 Feb 18.

Laboratorio de Genómica Funcional, Instituto Nacional de Medicina Genómica, Ciudad de México, México. Electronic address:

Background: MT4-MMP is a member of the metalloproteinases family, although with a controversial role in the extracellular matrix remodelation. Overexpression of this metalloproteinase has been observed in breast cancer and it has been suggested that it can regulate tumor growth and cancer progression. The mechanisms by which MT4-MMP participates in breast cancer includes tumor blood vessels desestabilization, the activation of an angiogenic switch, and increase of EGFR signaling. Read More

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http://dx.doi.org/10.1016/j.arcmed.2019.02.001DOI Listing
February 2019

[Hospital-at-home Integrated Care Programme tailored to older patients with disabling acute processes: identification of prognostic factors].

Rev Esp Geriatr Gerontol 2019 Feb 18. Epub 2019 Feb 18.

Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, España; Parc Sanitari Pere Virgili, Barcelona, España.

Introduction: Several authors have demonstrated the efficacy of different hospital-at-home strategies in older patients. The identification of prognostic factors is key for improving the targeting process of candidates.

Methods: We performed an analysis of a cohort of older patients attended due to disabling health crises (medical, orthopaedics, or stroke) by a hospital-at-home scheme developed in an integrated care institution over a 5-year period. Read More

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http://dx.doi.org/10.1016/j.regg.2018.11.005DOI Listing
February 2019

[School meals in Spain: an opportunity to promote more sustainable and healthy food systems].

Gac Sanit 2019 Feb 18. Epub 2019 Feb 18.

Grupo de Investigación de Salud Pública, Universidad de Alicante, Alicante, España; Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia, Universidad de Alicante, Alicante, España.

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http://dx.doi.org/10.1016/j.gaceta.2018.12.005DOI Listing
February 2019

Cystatin C in Pleural Effusion.

Arch Bronconeumol 2019 Feb 18. Epub 2019 Feb 18.

Sección de Neumología, Hospital General Universitario de Elche, Elche, Alicante, España.

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http://dx.doi.org/10.1016/j.arbres.2019.01.007DOI Listing
February 2019

WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to solar ultraviolet radiation and of the effect of occupational exposure to solar ultraviolet radiation on melanoma and non-melanoma skin cancer.

Environ Int 2019 Feb 18. Epub 2019 Feb 18.

Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany; Institute for Interdisciplinary Dermatological Prevention and Rehabilitation (iDerm) at the University of Osnabrück, Lower-Saxonian Institute of Occupational Dermatology, Osnabrück, Germany. Electronic address:

Background: The World Health Organization (WHO) and the International Labour Organization (ILO) are developing a joint methodology for estimating the national and global work-related burden of disease and injury (WHO/ILO joint methodology), with contributions from a large network of experts. In this paper, we present the protocol for two systematic reviews of parameters for estimating the number of deaths and disability-adjusted life years from melanoma and non-melanoma skin cancer (or keratinocyte carcinoma) from occupational exposure to solar ultraviolet radiation, to inform the development of the WHO/ILO joint methodology.

Objectives: We aim to systematically review studies on occupational exposure to solar ultraviolet radiation (Systematic Review 1) and systematically review and meta-analyse estimates of the effect of occupational exposure to solar ultraviolet radiation on melanoma and non-melanoma skin cancer (Systematic Review 2), applying the Navigation Guide systematic review methodology as an organizing framework and conducting both systematic reviews in tandem and in a harmonized way. Read More

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http://dx.doi.org/10.1016/j.envint.2018.09.039DOI Listing
February 2019

Metformin-associated hyperlactacidaemia acidosis: Diagnosis rate in standard clinical practice and its relationship with renal failure.

Rev Clin Esp 2019 Feb 18. Epub 2019 Feb 18.

Unidad de Investigación, Hospital Universitario de Canarias, Complejo Hospitalario Universitario de Canarias, Servicio Canario de la Salud, San Cristóbal de La Laguna, Tenerife, Islas Canarias, España.

Background And Objectives: Observational study on the difference between the number of cases of acidosis with hyperlactacidaemia suspected of being caused by metformin diagnosed in standard clinical practice and the incidence of this condition according to the datasheet. The study also explored the relationship between renal function and metformin-associated hyperlactacidaemia acidosis.

Patients: We identified cases of acidosis between 2013 and 2014 by analysing the minimum basic data set and laboratory requests. Read More

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http://dx.doi.org/10.1016/j.rce.2018.11.006DOI Listing
February 2019

Would you like to know your healthcare results in terms of quality?

Authors:
J Canora Lebrato

Rev Clin Esp 2019 Feb 18. Epub 2019 Feb 18.

Presidente de SOMIMACA, Servicio de Medicina Interna, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, España. Electronic address:

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http://dx.doi.org/10.1016/j.rce.2019.01.005DOI Listing
February 2019

Internists and death in the hospital.

Rev Clin Esp 2019 Feb 18. Epub 2019 Feb 18.

Sección de Medicina Interna, Hospital Universitario Clínico San Carlos, Madrid, España.

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http://dx.doi.org/10.1016/j.rce.2019.01.002DOI Listing
February 2019

A major monoclonal hospital outbreak of NDM-1-producing Klebsiella pneumoniae ST340 and the first report of ST2570 in Brazil.

Infect Control Hosp Epidemiol 2019 Feb 22:1-2. Epub 2019 Feb 22.

Division of Infectious Diseases, Department of Internal Medicine,Universidade Federal de São Paulo,Escola Paulista de Medicina, São Paulo,Brazil.

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http://dx.doi.org/10.1017/ice.2018.333DOI Listing
February 2019

Combined Effect of Diosgenin Along with Ezetimibe or Atorvastatin on the Fate of Labelled Bile Acid and Cholesterol in Hypercholesterolemic Rats.

Int J Environ Res Public Health 2019 Feb 20;16(4). Epub 2019 Feb 20.

Facultad de Medicina, División de Investigación, Departamento de Bioquímica, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de México C.P. 04510, Ciudad de México, Mexico.

We analyzed the effect of diosgenin, administered with atorvastatin or ezetimibe, on the fate of ³H(G)-taurocholic acid or 26-C-cholesterol in hypercholesterolemic rats. Male Wistar rats received a hypercholesterolemic diet (HD), HD + atorvastatin (HD+ATV), HD + ezetimibe (HD+EZT), HD + diosgenin (HD+DG), HD+ATV+EZT, or HD+ATV+DG for 40 days. We also included a control normal group (ND). Read More

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http://dx.doi.org/10.3390/ijerph16040627DOI Listing
February 2019

The Diversified O-Superfamily in Presents a Conotoxin with Antimycobacterial Activity.

Toxins (Basel) 2019 Feb 20;11(2). Epub 2019 Feb 20.

Departamento de Innovación Biomédica, CICESE, Carretera Ensenada-Tijuana 3918, Ensenada, BC C.P. 22860, Mexico.

, previously named , has always been considered a unique species within cone snails, because of its molecular, toxicological and morphological singularities; including the wide range of its diet, since it is capable of preying indifferently on fish, snails, octopus, shrimps, and worms. We report here a new cysteine pattern conotoxin assigned to the O1-superfamily capable of inhibiting the growth of (Mtb). The conotoxin was tested on a pathogen reference strain (H37Rv) and multidrug-resistant strains, having an inhibition effect on growth with a minimal inhibitory concentration (MIC) range of 3. Read More

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http://dx.doi.org/10.3390/toxins11020128DOI Listing
February 2019

A Single-Nucleotide Polymorphism of αβ₃ Integrin Is Associated with the Andes Virus Infection Susceptibility.

Viruses 2019 Feb 20;11(2). Epub 2019 Feb 20.

Departamento de Enfermedades Infecciosas e Inmunologia Pediatricas, División de Pediatría, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.

The (ANDV), which causes the hantavirus cardiopulmonary syndrome, enters cells via integrins, and a change from leucine to proline at residue 33 in the PSI domain (L33P), impairs ANDV recognition. We assessed the association between this human polymorphism and ANDV infection. We defined susceptible and protective genotypes as "TT" (coding leucine) and "CC" (coding proline), respectively. Read More

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http://dx.doi.org/10.3390/v11020169DOI Listing
February 2019

Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity.

Int J Mol Sci 2019 Feb 19;20(4). Epub 2019 Feb 19.

Sezione di Farmacologia, Dipartimento di Medicina Interna & Centro di Eccellenza per la Ricerca Biomedica (CEBR), Università di Genova, 16132 Genova, Italy.

The aim of this review is to critically analyze promises and limitations of pharmacological inducers of autophagy against protein misfolding-associated neurodegeneration. Effective therapies against neurodegenerative disorders can be developed by regulating the "self-defense" equipment of neurons, such as autophagy. Through the degradation and recycling of the intracellular content, autophagy promotes neuron survival in conditions of trophic factor deprivation, oxidative stress, mitochondrial and lysosomal damage, or accumulation of misfolded proteins. Read More

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http://dx.doi.org/10.3390/ijms20040901DOI Listing
February 2019

Dissecting Intra-Tumor Heterogeneity by the Analysis of Copy Number Variations in Single Cells: The Neuroblastoma Case Study.

Int J Mol Sci 2019 Feb 19;20(4). Epub 2019 Feb 19.

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.

Tumors often show intra-tumor heterogeneity because of genotypic differences between all the cells that compose it and that derive from it. Recent studies have shown significant aspects of neuroblastoma heterogeneity that may affect the diagnostic-therapeutic strategy. Therefore, we developed a laboratory protocol, based on the combination of the advanced dielectrophoresis-based array technology and next-generation sequencing to identify and sort single cells individually and carry out their copy number variants analysis. Read More

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http://dx.doi.org/10.3390/ijms20040893DOI Listing
February 2019

New Insights into the Role of Epithelial⁻Mesenchymal Transition during Aging.

Int J Mol Sci 2019 Feb 19;20(4). Epub 2019 Feb 19.

Department of Medical Sciences and Institute of Biomedicine-iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal.

Epithelial⁻mesenchymal transition (EMT) is a cellular process by which differentiated epithelial cells undergo a phenotypic conversion to a mesenchymal nature. The EMT has been increasingly recognized as an essential process for tissue fibrogenesis during disease and normal aging. Higher levels of EMT proteins in aged tissues support the involvement of EMT as a possible cause and/or consequence of the aging process. Read More

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http://dx.doi.org/10.3390/ijms20040891DOI Listing
February 2019

Child Sexual Abuse Perpetrated by Women: Case Series and Review of the Literature.

J Forensic Sci 2019 Feb 21. Epub 2019 Feb 21.

Dipartimento di Scienze della Sanità Pubblica e Pediatriche, Sezione di Medicina Legale, "Università degli Studi di Torino", corso Galileo Galilei 22, 10126, Torino, Italia.

The literature on child sexual abuse (CSA) perpetrated by female sexual offenders (FSOs) is exiguous, and many studies have focused on judicial databases. The present retrospective study, instead, analyzed clinical and judicial data of a group of both victims and alleged FSOs, to additionally include women who have not been convicted by the criminal justice system, but who hold strong clinical suspicions of being perpetrators of CSA. The medical records and the Court files of 11 children and their eight suspected FSOs have been collected and critically reviewed in light of the literature to date. Read More

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http://dx.doi.org/10.1111/1556-4029.14033DOI Listing
February 2019

Novel use of a cardiac septal occluder to treat a chronic recalcitrant bariatric fistula after Roux-en-Y gastric bypass.

Endoscopy 2019 Feb 21. Epub 2019 Feb 21.

Gastrointestinal Endoscopy Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1055/a-0842-6287DOI Listing
February 2019

Dietary supplementation of sunflower oil and quebracho tannins in sheep feeding: In vivo nutrient digestibility, nitrogen utilization and in vitro ruminal degradation kinetics.

J Sci Food Agric 2019 Feb 20. Epub 2019 Feb 20.

Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, Mexico.

Background: The effect of inclusion of sunflower oil (SF) and quebracho tannin (QT) to sheep diet was evaluated. Nutrient digestibility and N utilization; and in vitro ruminal degradation kinetics were evaluated at three levels (0, 20 and 40 g kg of diet dry matter (DM)) of SF and QT in a 3 arrangement. The treatments were 0 (control); 20 and 40 g of QT and/or SF kg of the diet. Read More

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http://dx.doi.org/10.1002/jsfa.9651DOI Listing
February 2019

Acute pericarditis or a systemic disease with pleuropulmonary involvement?

Intern Emerg Med 2019 Feb 21. Epub 2019 Feb 21.

Department of Biomedical and Clinical Sciences "Luigi Sacco", ASST Fatebenefratelli-Sacco, University of Milan, Milan, Italy.

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http://dx.doi.org/10.1007/s11739-019-02057-9DOI Listing
February 2019

Multi-behavioral obesogenic phenotypes among school-aged boys and girls along the birth weight continuum.

PLoS One 2019 21;14(2):e0212290. Epub 2019 Feb 21.

Desautels Faculty of Management, McGill Center for the Convergence of Health and Economics, McGill University, Montreal, QC, Canada.

Evidence shows that extremes of birth weight (BW) carry a common increased risk for the development of adiposity and related cardiovascular diseases, but little is known about the role of obesogenic behaviors in this process. Moreover, no one has empirically examined whether the relationship between BW, obesogenic behaviors and BMI along the full low-to-high birthweight continuum reflects the U-shape pattern expected from common risk at both BW extremes. Our objective was to characterize physical activity, screen time, and eating behavior and their relationship to BMI as a function of BW among school-aged boys and girls. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212290PLOS
February 2019

Extracellular vesicles of Trypanosoma cruzi tissue-culture cell-derived trypomastigotes: Induction of physiological changes in non-parasitized culture cells.

PLoS Negl Trop Dis 2019 Feb 21;13(2):e0007163. Epub 2019 Feb 21.

Instituto de Biotecnología, Grupo de Bioquímica y Parasitología Molecular, Departamento de Parasitología, Universidad de Granada, Granada, Spain.

Background: Trypanosoma cruzi is the obligate intracellular parasite that causes Chagas disease. The pathogenesis of this disease is a multifactorial complex process that involves a large number of molecules and particles, including the extracellular vesicles. The presence of EVs of T. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007163DOI Listing
February 2019

Echinococcus granulosus in the Endangered Patagonian Huemul ( Hippocamelus bisulcus).

J Wildl Dis 2019 Feb 21. Epub 2019 Feb 21.

1 Instituto de Medicina Preventiva Veterinaria, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile.

Cystic echinococcosis (CE) is a zoonotic parasitic disease associated with Echinococcus granulosus. The parasite is maintained by domestic and wild canids as definitive hosts with several ungulate species as intermediate hosts in domestic and peridomestic transmission cycles. In Chile, CE is endemic, and the role of livestock and dogs ( Canis lupus familiaris) in the cycle and the accidental infection of humans are widely documented at rural sites. Read More

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February 2019

Anticoagulation for Portal Vein Thrombosis in Cirrhosis.

Authors:
Andrea Mancuso

Am J Gastroenterol 2019 Feb 14. Epub 2019 Feb 14.

Medicina Interna 1, ARNAS Civico-Di Cristina-Benfratelli, Palermo, Italy.

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http://dx.doi.org/10.14309/ajg.0000000000000158DOI Listing
February 2019

Antimicrobial management of Tropheryma whipplei endocarditis: the Spanish Collaboration on Endocarditis (GAMES) experience.

J Antimicrob Chemother 2019 Feb 20. Epub 2019 Feb 20.

Departamento de Enfermedades Infecciosas, Hospital Universitario San Pedro-Centro de investigación Biomédica de La Rioja (CIBIR), Logroño, Spain.

Objectives: Tropheryma whipplei has been detected in 3.5% of the blood culture-negative cases of endocarditis in Spain. Experience in the management of T. Read More

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http://dx.doi.org/10.1093/jac/dkz059DOI Listing
February 2019

Comment on "Shiatsu as an Adjuvant Therapy for Depression in Patients With Alzheimer's Disease: A Pilot Study".

J Evid Based Integr Med 2019 Jan-Dec;24:2515690X18825105

2 University "Kore" of Enna, Enna, Italy.

Recently, there has been increasing interest toward nonpharmacological approaches for dementia and associated clinical manifestations, such as depression, with the common goal to improve health and quality of life of both patients and caregivers. In this scenario, the role of Shiatsu is of clinical and research interest, although to date a definitive recommendation on a systematic use in clinical practice cannot be made. To overcome the heterogeneity of the previous studies, we tested Shiatsu as an add-on treatment for late-life depression in a dedicated community of patients with mild-to-moderate Alzheimer's disease. Read More

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http://dx.doi.org/10.1177/2515690X18825105DOI Listing
February 2019

Outbreak of Guillain-Barre syndrome in Peru.

eNeurologicalSci 2019 Mar 7;14:89-90. Epub 2019 Feb 7.

Unidad de Investigación Básica y Traslacional, Oncosalud - AUNA, Lima, Peru.

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http://dx.doi.org/10.1016/j.ensci.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369118PMC