149,986 results match your criteria Medicina intensiva / Sociedad Espanola de Medicina Intensiva y Unidades Coronarias[Journal]


Management of CPAP-Induced Ocular Air Reflux Due to a Porous Polyethylene-Coated Lester Jones Tube.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):419-421. Epub 2019 Apr 18.

Department of Oculoplastic Surgery, Hospital Sao Geraldo, Universidade Federal de Minas Gerais Faculdade de Medicina, Belo Horizonte, Brazil.

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http://dx.doi.org/10.1055/a-0799-9777DOI Listing

The effect of nitric oxide on mitochondrial respiration.

Nitric Oxide 2019 Apr 15. Epub 2019 Apr 15.

Universidad de Buenos Aires, Facultad de Medicina, Departamento de Bioquímica Humana, Paraguay 2155 5th Floor, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, Instituto de Investigaciones Biomédicas (INBIOMED), Buenos Aires, Argentina. Electronic address:

This article reviews the interactions between nitric oxide (NO) and mitochondrial respiration. Mitochondrial ATP synthesis is responsible for virtually all energy production in mammals, and every other process in living organisms ultimately depends on that energy production. Furthermore, both necrosis and apoptosis, that summarize the main forms of cell death, are intimately linked to mitochondrial integrity. Read More

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http://dx.doi.org/10.1016/j.niox.2019.04.005DOI Listing

Identification of circumferential regional heterogeneity of ascending thoracic aneurysmal aorta by biaxial mechanical testing.

J Mol Cell Cardiol 2019 Apr 15. Epub 2019 Apr 15.

Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS-ISMETT, Via Tricomi n.5, 90127 Palermo, Italy.

Ascending thoracic aortic aneurysm (ATAA) in patients with bicuspid aortic valve (BAV) can present an asymmetrical aortic dilatation compared with patients with tricuspid aortic valve (TAV). This pattern of aneurysm dilatation led us to hypothesize that biomechanical differences likely induced by regional heterogeneity of material properties can underlie the observed asymmetric enlargement discrepancies between BAV ATAA and TAV ATAA. This study aimed to characterize the mechanical properties and associated aortic tissue stiffness changes along the circumferential direction of aortic rings collected from surgically-repaired patients with ATAA. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2019.04.010DOI Listing

Unveiling toxicological aspects of venom from the Aesculapian False Coral Snake Erythrolamprus aesculapii.

Toxicon 2019 Apr 15. Epub 2019 Apr 15.

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto Nacional de Medicina Tropical (INMeT), Neuquén y Jujuy s/n, 3370, Puerto Iguazú, Argentina. Electronic address:

Most colubrid snake venoms have been poorly studied, despite the fact that they represent a great resource for biological, ecological, toxinological and pharmacological research. Herein, we explore the venom delivery system of the Aesculapian False Coral Snake Erythrolamprus aesculapii as well as some biochemical and toxicological properties of its venom. Its Duvernoy's venom gland is composed of serous secretory cells arranged in densely packed secretory tubules, and the most striking feature of its fang is their double-curved shape, exhibiting a beveled bladelike appearance near the tips. Read More

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http://dx.doi.org/10.1016/j.toxicon.2019.04.007DOI Listing

Exosomes on the border of species and kingdom intercommunication.

Transl Res 2019 Mar 29. Epub 2019 Mar 29.

Consorcio Regenero, Chilean Consortium for Regenerative Medicine, Santiago, Chile; Cells for Cells, Santiago, Chile; Laboratory of Nano-Regenerative Medicine, Faculty of Medicine, Universidad de los Andes, Santiago, Chile. Electronic address:

Over the last decades exosomes have become increasingly popular in the field of medicine. While until recently they were believed to be involved in the removal of obsolete particles from the cell, it is now known that exosomes are key players in cellular communication, carrying source-specific molecules such as proteins, growth factors, miRNA/mRNA, among others. The discovery that exosomes are not bound to intraspecies interactions, but are also capable of interkingdom communication, has once again revolutionized the field of exosomes research. Read More

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http://dx.doi.org/10.1016/j.trsl.2019.03.008DOI Listing

Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction.

Crit Care Med 2019 Apr 15. Epub 2019 Apr 15.

Departamento de Ciencias Biologicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile.

Objectives: To determine whether circulating endothelial cells from septic shock patients and from nonseptic shock patients are transformed in activated fibroblast by changing the expression level of endothelial and fibrotic proteins, whether the level of the protein expression change is associated with the amount of administered resuscitation fluid, and whether this circulating endothelial cell protein expression change is a biomarker to predict sepsis survival.

Design: Prospective study.

Setting: Medical-surgical ICUs in a tertiary care hospital. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003778DOI Listing

Ferrocenes with simple chiral substituents: an in-depth theoretical and experimental VCD and ECD study.

Phys Chem Chem Phys 2019 Apr 18. Epub 2019 Apr 18.

Scuola Normale Superiore, Piazza dei Cavalieri 7, I-56126 Pisa, Italy.

Circular dichroism spectra in the IR range (VCD = vibrational circular dichroism) and in the UV range (ECD = electronic circular dichroism) have been recorded for both enantiomers of simple mono-substituted ferrocenes containing chiral pendants: 1-acetoxyethylferrocene, 1, 1-methoxyethylferrocene, 2, and 1-hydroxyethylferrocene, 3; the related disubstituted 1,1'-bis(1-hydroxyethyl)ferrocene, 4, was also considered. These two types of spectra, with the support of DFT calculations, concur to unequivocally confirm the absolute configuration for 1-4. In particular, our computational results point out the clear advantage of using an anharmonic oscillator model for the interpretation of VCD spectra of chiral ferrocenes. Read More

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http://dx.doi.org/10.1039/c9cp00437hDOI Listing
April 2019
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Florid mesothelial hyperplasia of the tunica vaginalis: report of two cases with immunohistochemical findings.

Int Urol Nephrol 2019 Apr 17. Epub 2019 Apr 17.

Imagepat Laboratory, Rua Lucaia, 209-Edf. Eventus Empresarial, Rio Vermelho, Salvador, 41940-660, Brazil.

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http://link.springer.com/10.1007/s11255-019-02153-x
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http://dx.doi.org/10.1007/s11255-019-02153-xDOI Listing
April 2019
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Tonic pupils: an unusual autonomic involvement in chronic inflammatory demyelinating polyneuropathy (CIDP).

Neurol Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo, 650, São Paulo, SP, 04039-002, Brazil.

Background: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neuropathy which affects mainly large myelinated axons and has a typically mild autonomic dysfunction mainly from postganglionic nerve fiber involvement.

Case Report: We report here an acute onset CIDP initially diagnosed as Guillain-Barré syndrome (GBS), unresponsive to treatment with intravenous immunoglobulin (IVIg), which later responded to plasmapheresis and corticoids. The patient had a markedly distal demyelination, prominent cranial nerve involvement and, interestingly, bilateral fixed dilated pupils. Read More

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http://dx.doi.org/10.1007/s10072-019-03890-8DOI Listing

A clinical evaluation of two central venous catheter stabilization systems.

Ann Intensive Care 2019 Apr 17;9(1):49. Epub 2019 Apr 17.

Corporate Division, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB, UK.

Background: Central venous catheters (CVCs) are commonly secured with sutures which are associated with microbial colonization and infection. We report a comparison of a suture-free system with standard sutures for securing short-term CVC in an international multicentre, prospective, randomized, non-blinded, observational feasibility study. Consented critical care patients who had a CVC inserted as part of their clinical management were randomized to receive either sutures or the suture-free system to secure their CVC. Read More

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http://dx.doi.org/10.1186/s13613-019-0519-6DOI Listing

Sonographic landmarks in hamstring muscles.

Skeletal Radiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiology, Diagnóstico Médico Cantabria (DMC), Santander, Cantabria, Spain.

The ultrasound examination of hamstrings inspires respect due to the connective complexity of their structures, particularly for sonographers who are not used to this kind of study. Therefore, it is important to know the specific ultrasound reference points that facilitate the location of the hamstring structures, dividing them into four areas of interest: (a) tendinous origin of the hamstring, (b) the proximal half, (c) distal and medial half, and (d) distal and lateral half. The origin of the hamstrings is found at the level of the ischial tuberosity. Read More

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http://dx.doi.org/10.1007/s00256-019-03208-xDOI Listing

Radiographic and histological evidence of metabolic bone disease in gliding leaf frogs ().

Heliyon 2019 Apr 5;5(4):e01432. Epub 2019 Apr 5.

Escuela de Medicina Veterinaria, Facultad de Ciencias de la Salud, Universidad de Las Américas, Colimes y Granados 170513, Ecuador.

Bone alterations due to metabolic bone disease in captive animal populations can have a negative impact on repopulation and research initiatives. This investigation has the purpose of describing the principal radiographic and anatomopathological findings present in nine gliding leaf frogs () kept in captivity with alterations in their spines and long bones. The observed histopathological findings were in the canalis vertebralis, paraspinal muscle and long bones, and included deformed bones with alteration of the adjacent tissues, alterations in the ossification process, bone degeneration and resorption, decreased number of osteocytes and deposition of osteoid and fibrous material in the compact bone tissue. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451164PMC

Retrospective analysis of iatrogenic diseases in cattle requiring admission to a veterinary hospital.

Vet Rec Open 2019 18;6(1):e000254. Epub 2019 Feb 18.

Dipartimento di Medicina Veterinaria, Universita degli Studi di Milano, Lodi, Italy.

Iatrogenic diseases in veterinary medicine are often related to malpractice or lack of skill. For this retrospective study, 4262 clinical records of cattle admitted to the veterinary teaching hospital of the University of Milan between 2005 and 2017 were analysed, and 121 cases (2.8 per cent), referred for an iatrogenic-related disease, were selected. Read More

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http://dx.doi.org/10.1136/vetreco-2017-000254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446213PMC
February 2019

Intravenous administration of Milrinone, as an alternative approach to treat vasospasm in subarachnoid hemorrhage: A case report of transcranial Doppler monitoring.

Clin Case Rep 2019 Apr 19;7(4):648-652. Epub 2019 Feb 19.

Critical Care Unit Hospital São Rafael Salvador Brazil.

This case illustrates the importance and potential of having TCD monitoring in intensive care. This easy-to-use, safe, low-cost, and bedside tool allows evaluation of the safety and feasibility of an alternative treatment of VSP in SCH and demonstrates the potential to avoid the use of angiography, a high cost, invasive procedure. Read More

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http://dx.doi.org/10.1002/ccr3.2034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452455PMC

Ubiquitin binds the amyloid β peptide and interferes with its clearance pathways.

Chem Sci 2019 Mar 10;10(9):2732-2742. Epub 2019 Jan 10.

Consiglio Nazionale delle Ricerche , Istituto di Biostrutture e Bioimmagini , Via P. Gaifami 18 , 95126 Catania , Italy . Email:

Several lines of evidence point to a compromised proteostasis associated with a reduction of the Ubiquitin Proteasome System (UPS) activity in patients affected by Alzheimer's Disease (AD) and suggest that the amyloid β peptide (Aβ) is an important player in the game. Inspired also by many reports, underlining the presence of ubiquitin (Ub) in the amyloid plaques of AD brains, here we set out to test whether Ub may bind the Aβ peptide and have any effect on its clearance pathways. By using an integrated array of MALDI-TOF/UPLC-HRMS, fluorescence, NMR, SPR, Microscale Thermophoresis (MST) and molecular dynamics studies, we consistently demonstrated that Aβ40 binds Ub with a 1 : 1 stoichiometry and in the high micromolar range. Read More

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http://xlink.rsc.org/?DOI=C8SC03394C
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http://dx.doi.org/10.1039/c8sc03394cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419943PMC
March 2019
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Highly enantioselective "inherently chiral" electroactive materials based on a 2,2'-biindole atropisomeric scaffold.

Chem Sci 2019 Mar 5;10(9):2708-2717. Epub 2019 Jan 5.

Dipartimento di Chimica , Università degli Studi di Milano , Via Golgi, 19 , 20133 Milano , Italy . Email:

Chiral oligothiophene monomers with symmetry, based on 3,3'-bithiophene atropisomeric cores with high racemization barriers, have recently been shown to provide excellent chiral starting materials with high electroactivity for the easy preparation of enantiopure electroactive films endowed with powerful chirality manifestations. We now introduce an inherently chiral monomer based on a 2,2'-biindole core, as the prototype of a new inherently chiral monomer family, whose properties could be modulable through functionalization of the pyrrolic N atoms. By fast, regular electrooligomerization the new monomer yields inherently chiral films with high, reversible electroactivity and, above all, impressive enantioselectivity towards very different chiral probes, some of pharmaceutical interest, as general-scope electrode surfaces. Read More

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http://dx.doi.org/10.1039/c8sc04862bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419939PMC

α,γ-Diketocarboxylic Acids and Their Esters Act as Carbonic Anhydrase IX and XII Selective Inhibitors.

ACS Med Chem Lett 2019 Apr 19;10(4):661-665. Epub 2019 Feb 19.

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy.

Among human carbonic anhydrase (CA) inhibitors, the α,γ-diketocarboxylic acids and esters are still poorly investigated. Here, we report the first compounds of this class (-) acting as potent inhibitors at low nanomolar level against the cancer-related human CA IX and XII, and 2-3 magnitude orders selective toward the cytosolic isoforms hCA I and II. At enzymatic level, the α,γ-diketoacids - were more effective inhibitors compared to the corresponding ethyl esters -. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.9b00023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466837PMC

Self-assembling Releasable Thiocolchicine-Diphenylbutenylaniline Conjugates.

ACS Med Chem Lett 2019 Apr 4;10(4):611-614. Epub 2019 Jan 4.

Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy.

The design and the synthesis of new self-assembling conjugates is reported. The target compounds are characterized by the presence of a self-immolative linker that secures a controlled release induced by lipase cleavage. 4-(1,2-Diphenylbut-1-en-1-yl)aniline is used as a self-assembling inducer and amino-thiocolchicine as prototype of drug. Read More

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http://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00605
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http://dx.doi.org/10.1021/acsmedchemlett.8b00605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466830PMC
April 2019
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Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists.

ACS Med Chem Lett 2019 Apr 10;10(4):504-510. Epub 2019 Jan 10.

Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, Naples 80131, Italy.

Recent findings have shown that Farnesoid X Receptor (FXR) antagonists might be useful in the treatment of cholestasis and related metabolic disorders. In this paper, we report the discovery of a new chemotype of FXR antagonists featured by a 3,5-disubstituted oxadiazole core. In total, 35 new derivatives were designed and synthesized, and notably, compounds and , containing a piperidine ring, displayed the best antagonistic activity against FXR with promising cellular potency (IC = 0. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466555PMC

L-DOPA-quinone Mediated Recovery from GIRK Channel Firing Inhibition in Dopaminergic Neurons.

ACS Med Chem Lett 2019 Apr 9;10(4):431-436. Epub 2019 Jan 9.

Dipartimento di Scienze Ecologiche e Biologiche, Università della Tuscia, Via S. C. De Lellis 44, 01100 Viterbo, Italy.

The oxidative degeneration of dopamine-releasing (DAergic) neurons in the substantia nigra pars compacta (SNc) has attracted much interest in preclinical research, due to its involvement in Parkinson's disease manifestations. Evidence exists on the participation of quinone derivatives in mitochondrial dysfunction, alpha synuclein protein aggregation, and protein degradation. With the aim to investigate the role of L-DOPA-quinone in DAergic neuron functions, we synthesized L-DOPA-quinone by use of 2-iodoxybenzoic acid and measured its activity in recovery from dopamine-mediated firing inhibition of SNc neurons. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466524PMC

Multifunctional Carrier Based on Halloysite/Laponite Hybrid Hydrogel for Kartogenin Delivery.

ACS Med Chem Lett 2019 Apr 22;10(4):419-424. Epub 2018 Oct 22.

Dipartimento STEBICEF, Sez. Chimica, Università degli Studi di Palermo, Viale delle Scienze, Ed. 17, 90128 Palermo, Italy.

A novel carrier system based on halloysite nanotubes (HNT), for the potential intraarticular delivery of kartogenin (KGN) by means laponite (Lap) hydrogel (HNT/KGN/Lap), is developed. The drug was first loaded into HNT, and the hybrid composite obtained was used as filler for laponite hydrogel. Both the filler and the hydrogel were thoroughly investigated by several techniques and the hydrogel morphology was imaged by transmission electron microscopy. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466553PMC

Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury.

ACS Med Chem Lett 2019 Apr 6;10(4):407-412. Epub 2018 Dec 6.

Department of Pharmacy, University of Naples "Federico II", via D. Montesano 49, 80131 Naples, Italy.

Acetaminophen misuse is a leading cause of acute liver failure and liver transplantation for which therapy is poorly effective. FXR ligands have shown effective in reducing liver injury in several experimental and clinical settings. In this Letter, we have elaborated on the structure of GW4064, the first nonsteroidal agonist for FXR, to identify novel isoxazoles endowed with FXR agonistic activity and improved ADME properties. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466548PMC

Reliability and reproducibility of a rodent model of choroidal neovascularization based on the subretinal injection of polyethylene glycol.

Mol Vis 2019 18;25:194-203. Epub 2019 Mar 18.

Instituto Universitario de Oftalmobiología Aplicada (IOBA), University of Valladolid, Valladolid, Spain.

Purpose: To evaluate the reliability and reproducibility of a rodent choroidal neovascularization (CNV) model by subretinal injection of polyethylene glycol (PEG).

Methods: C57BL/6 mice were injected subretinally with 2 μl PBS (Gibco, Invitrogen, Paisley, UK; n=14) or PEG (1 mg; n=18). Animals were sacrificed at either 0, 5, 14 or 21 days. Read More

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Epidemiological Study of the Socioeconomic Impact of Mandible Fractures in a Spanish Tertiary Hospital: Review of the Literature.

J Maxillofac Oral Surg 2019 Jun 28;18(2):217-223. Epub 2018 Aug 28.

1Oral and Maxillofacial Department, Miguel Servet University Hospital, Paseo Isabel la Católica, 1-3, 50009 Zaragoza, Spain.

Introduction: Mandibles fractures are one of the most frequent pathologies treated in an Oral and Maxillofacial Department and represent a serious public health problem.

Materials And Methods: We present a retrospective study of patients treated for mandible fractures by the Oral and Maxillofacial Surgery Department in a Spanish tertiary hospital during 2010-2012.

Results: One hundred and thirty-nine patients with 201 mandible fracture sites were assisted in our department; 15% were female and 85% were male, with a male-to-female ratio of 5. Read More

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http://dx.doi.org/10.1007/s12663-018-1148-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441432PMC

Data from the Human Penguin Project, a cross-national dataset testing social thermoregulation principles.

Sci Data 2019 Apr 17;6(1):32. Epub 2019 Apr 17.

LIP/PC2S, Université Grenoble Alpes, Grenoble Alpes, France.

In the Human Penguin Project (N = 1755), 15 research groups from 12 countries collected body temperature, demographic variables, social network indices, seven widely-used psychological scales and two newly developed questionnaires (the Social Thermoregulation and Risk Avoidance Questionnaire (STRAQ-1) and the Kama Muta Frequency Scale (KAMF)). They were collected to investigate the relationship between environmental factors (e.g. Read More

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http://dx.doi.org/10.1038/s41597-019-0029-2DOI Listing

Author Correction: Selective Inhibition of Succinate Dehydrogenase in Reperfused Myocardium with Intracoronary Malonate Reduces Infarct Size.

Sci Rep 2019 Apr 17;9(1):6395. Epub 2019 Apr 17.

Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma de Barcelona, Departament de Medicina, Barcelona, Spain.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More

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http://dx.doi.org/10.1038/s41598-019-42591-2DOI Listing

Dorsally exophytic glioblastoma of the pons.

BMJ Case Rep 2019 Apr 16;12(4). Epub 2019 Apr 16.

Departamento de Especialidades Cirúrgicas, Universidade Federal do Rio de Janeiro Hospital Universitario Clementino Fraga Filho, Rio de Janeiro, Brazil.

Brainstem gliomas are rare tumours in adults, accounting for only 1%-2% of all intracranial gliomas. They are recognised as a heterogeneous group, in which most are malignant tumours. Brainstem gliomas are classified into four major groups according to the growth pattern on imaging, namely diffuse, focal, exophytic and cervicomedullary. Read More

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http://dx.doi.org/10.1136/bcr-2018-228105DOI Listing

Brody disease: when myotonia is not myotonia.

Pract Neurol 2019 Apr 17. Epub 2019 Apr 17.

Neurology Department, Centro Hospitalar Universitário de São João, Porto, Portugal.

A 56-year-old man presented with painless impairment of muscle relaxation on vigorous contraction (eg, eyelid closure, hand grip, running). There were no episodes of paralysis, symptom progression, weakness or extramuscular symptoms. Five of his fifteen siblings had similar complaints. Read More

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http://dx.doi.org/10.1136/practneurol-2019-002224DOI Listing

Sedation practices and clinical outcomes in mechanically ventilated patients in a prospective multicenter cohort.

Crit Care 2019 Apr 17;23(1):130. Epub 2019 Apr 17.

Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, 1830 E Monument St., Suite 555, Baltimore, MD, 21287, USA.

Objectives: We sought to study the association between sedation status, medications (benzodiazepines, opioids, and antipsychotics), and clinical outcomes in a resource-limited setting.

Design: A longitudinal study of critically ill participants on mechanical ventilation.

Setting: Five intensive care units (ICUs) in four public hospitals in Lima, Peru. Read More

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http://dx.doi.org/10.1186/s13054-019-2394-9DOI Listing

Association between emergency department length of stay and adverse perioperative outcomes in emergency surgery: a cohort study in two Colombian University hospitals.

BMC Emerg Med 2019 Apr 17;19(1):27. Epub 2019 Apr 17.

Grupo de Cardiología Preventiva, Facultad de Ciencias de la Salud, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia.

Background: In low- and middle-income countries emergency surgery represents a higher proportion of the total number of surgeries and is associated with greater morbidity/mortality. Study aims were to determine if emergency department length of stay (ED-LOS) was associated with adverse perioperative outcomes and if such association varied across patient's risk categories.

Methods: A retrospective cohort study was conducted of adult patients who underwent orthopedic or abdominal emergency surgery at two Colombian University hospitals. Read More

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https://bmcemergmed.biomedcentral.com/articles/10.1186/s1287
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http://dx.doi.org/10.1186/s12873-019-0241-6DOI Listing
April 2019
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Rates, Predictors and Mortality of Community-Onset Bloodstream Infections due to Pseudomonas aeruginosa: Systematic Review and Meta-Analysis.

Clin Microbiol Infect 2019 Apr 14. Epub 2019 Apr 14.

Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena / Departamento de Medicina, Universidad de Sevilla / Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain.

Background: Pseudomonas aeruginosa is mostly a nosocomial pathogen affecting predisposed patients. However, community-onset bloodstream infections (CO-BSI) caused by this organism are not exceptional.

Objectives: To assess the predisposing factors for CO-BSI due to P. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.04.005DOI Listing

Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1.

N Engl J Med 2019 04;380(16):1525-1534

From the Departments of Bone Marrow Transplantation and Cellular Therapy (E.M., B.T., W.J., S.G.), Hematology (S.Z., Z.M., J.C., J.D., X.T., B.Y.R., M.J.W., B.P.S.), Therapeutics Production and Quality (T.L., M.M.M.), Immunology (H.A., B.Y.), Pharmaceutical Sciences (S.J.C.), Biostatistics (G.K., C.L.), and Infectious Diseases (G.M.), St. Jude Children's Research Hospital, Memphis, TN; the Allergy and Clinical Immunology Division, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru (J.C.A.B.); the Department of Pediatrics, Allergy-Immunology Division, Children's Hospital Los Angeles, Los Angeles (J.A.C.), and the Department of Pediatrics, Division of Pediatric Allergy-Immunology-Bone Marrow Transplantation, University of California, San Francisco (UCSF) Benioff Children's Hospital, San Francisco (J.R.L.-B., J.M.P., M.J.C.) - both in California; the Department of Pediatrics, Pediatric Allergy and Immunology, University of New Mexico, Albuquerque (E.D.); University of Oklahoma Health Sciences Center, Tulsa (J.T.L.); Departamento de Pediatria da Universidade de Taubaté, Conselho Nacional de Medicina, São Paulo (A.C.M.A.); Copperfield Childcare, Claremont, South Africa (H.W.); and the Genetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (S.S.D.R., H.L.M.).

Background: Allogeneic hematopoietic stem-cell transplantation for X-linked severe combined immunodeficiency (SCID-X1) often fails to reconstitute immunity associated with T cells, B cells, and natural killer (NK) cells when matched sibling donors are unavailable unless high-dose chemotherapy is given. In previous studies, autologous gene therapy with γ-retroviral vectors failed to reconstitute B-cell and NK-cell immunity and was complicated by vector-related leukemia.

Methods: We performed a dual-center, phase 1-2 safety and efficacy study of a lentiviral vector to transfer complementary DNA to bone marrow stem cells after low-exposure, targeted busulfan conditioning in eight infants with newly diagnosed SCID-X1. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1815408
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http://dx.doi.org/10.1056/NEJMoa1815408DOI Listing
April 2019
5 Reads

Effects of Colombian oregano essential oil (Lippia origanoides Kunth) and Eimeria species on broiler production and cecal microbiota.

Poult Sci 2019 Apr 17. Epub 2019 Apr 17.

Facultad de Medicina Veterinaria y de Zootecnia, Universidad Nacional de Colombia, Bogotá 11001, Colombia.

The gut microbiota has an important effect on poultry health and production. The aim of this study was to evaluate the effect of Colombian oregano (COO), Lippia origanoides Kunth, essential oil supplementation on broiler chicken performance and their cecal bacterial microbiome by 16S-based sequencing. Essential oil was extracted by steam distillation and analyzed by Gas chromatography/mass spectrometry. Read More

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http://dx.doi.org/10.3382/ps/pez193DOI Listing

Maternal Cell Phone Use During Pregnancy, Pregnancy Duration And Fetal Growth In Four Birth Cohorts.

Am J Epidemiol 2019 Apr 17. Epub 2019 Apr 17.

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.

Previous studies evaluating potential effects of prenatal exposure to radiofrequency fields from cell phones on birth outcomes are inconsistent. We explored if maternal cell phone use was associated with pregnancy duration and fetal growth. We used information from 55,507 pregnant women and their children from Denmark (1996-2002), the Netherlands (2003-2004), Spain (2003-2008) and Korea (2006-2011). Read More

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http://dx.doi.org/10.1093/aje/kwz092DOI Listing

Patterns of funerary variability, diet, and developmental stress in a Celtic population from NE Italy (3rd-1st c BC).

PLoS One 2019 17;14(4):e0214372. Epub 2019 Apr 17.

Department of Anthropology and Anthropological Museum, Universität Zürich-Irchel, Zürich, Switzerland.

Little is known about the types of social organization characterizing the pre-Roman Celtic populations of Italy. Here, we explore the funerary variability characterizing the late Iron Age site of Seminario Vescovile (SV: Verona, Italy, 3rd-1st c. BC), and test its possible correlation to diet and relative exposure to developmental stressors. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214372PLOS

Putative parapoxvirus-associated foot disease in the endangered huemul deer (Hippocamelus bisulcus) in Bernardo O'Higgins National Park, Chile.

PLoS One 2019 17;14(4):e0213667. Epub 2019 Apr 17.

One Health Institute, School of Veterinary Medicine, University of California, Davis, CA, United States of America.

The huemul (Hippocamelus bisulcus) is an endangered cervid endemic to southern Argentina and Chile. Here we report foot lesions in 24 huemul from Bernardo O'Higgins National Park, Chile, between 2005 and 2010. Affected deer displayed variably severe clinical signs, including lameness and soft tissue swelling of the limbs proximal to the hoof or in the interdigital space, ulceration of the swollen tissues, and some developed severe proliferative tissue changes that caused various types of abnormal wear, entrapment, and/or displacement of the hooves and/or dewclaws. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213667PLOS

LIMPRINT in Specialist Lymphedema Services in United Kingdom, France, Italy, and Turkey.

Lymphat Res Biol 2019 Apr;17(2):141-146

4 Montpellier Medecine Vasculaire, EA2992, Universite Montpellier I, CHU Saint Eloi, Montpellier, France.

There is no standardized international model for specialist lymphedema services, which covers the types of lymphedema treated and the treatments provided. The aim of this study was to provide a profile of patients attending specialist lymphedema services in different countries to explore similarities and differences. The LIMPRINT core tool was used in specialist lymphedema services in the United Kingdom, France, Italy, and Turkey. Read More

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https://www.liebertpub.com/doi/10.1089/lrb.2019.0021
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http://dx.doi.org/10.1089/lrb.2019.0021DOI Listing
April 2019
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Identification of dehydroxy isoquine and isotebuquine as promising antileishmanial agents.

Arch Pharm (Weinheim) 2019 Apr 17:e1800281. Epub 2019 Apr 17.

Laboratorio de Ingeniería Genética, Instituto de Biomedicina, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela.

Traditional antimalarial drugs based on 4-aminoquinolines have exhibited good antiproliferative activities against Leishmania parasites; however, their clinical use is currently limited. To identify new 4-aminoquinolines to combat American cutaneous leishmaniasis, we carried out a full in vitro evaluation of a series of dehydroxy isoquines and isotebuquines against two Leishmania parasites such as Leishmania braziliensis and Leishmania mexicana. First, the antiproliferative activity of the quinolines was studied against the promastigote forms of L. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ardp.2018002
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http://dx.doi.org/10.1002/ardp.201800281DOI Listing
April 2019
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Graph-Based data integration from bioactive peptide databases of pharmaceutical interest: towards an organized collection enabling visual network analysis.

Bioinformatics 2019 Apr 17. Epub 2019 Apr 17.

Departamento de Ciencias de la Computación, Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE), Baja California, Mexico.

Motivation: Bioactive peptides have gained great attention in the academy and pharmaceutical industry since they play an important role in human health. However, the increasing number of bioactive peptide databases is causing the problem of data redundancy and duplicated efforts. Even worse is the fact that the available data is non-standardized and often dirty with data entry errors. Read More

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http://dx.doi.org/10.1093/bioinformatics/btz260DOI Listing

Semantic memory, but not education or intelligence, moderates cognitive aging: a cross-sectional study.

Braz J Psychiatry 2019 Apr 15. Epub 2019 Apr 15.

Departamento de Saúde Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.

Objective: Aging studies regularly assume that years of education are a protective factor for baseline cognition. In developing countries with specific sociocultural issues, this relationship may not work as expected, and an unmet need remains for alternative resilience factors. This study aimed to analyze different moderators for the relationship between aging and general cognition that could reflect better protective factors. Read More

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http://dx.doi.org/10.1590/1516-4446-2018-0290DOI Listing

Predictors of quality of life in Brazilian medical students: a systematic review and meta-analysis.

Braz J Psychiatry 2019 Apr 15. Epub 2019 Apr 15.

Departamento e Instituto de Psiquiatria, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.

Objective: To examine predictors associated with quality of life (QoL) in Brazilian medical students.

Methods: PubMed, PsycINFO, EMBASE, LILACS, and Google Scholar were searched for research articles in English or Portuguese published through August 2018. Observational studies that measured QoL with standard instruments were selected. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1516-4446-2018-0116DOI Listing
April 2019
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Systemic dissemination of glioblastoma: literature review.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):460-468. Epub 2019 Apr 11.

Department of Radiology and Oncology, Division of Radiation Oncology, Instituto do Câncer do Estado de São Paulo (Icesp), Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brasil.

Introduction: Glioblastoma (GBM) is the most frequent primary malignant tumor from the central nervous system in adults. However, the presence of systemic metastasis is an extremely rare event. The objective of this study was to review the literature, evaluating the possible biological mechanisms related to the occurrence of systemic metastasis in patients diagnosed with GBM. Read More

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http://dx.doi.org/10.1590/1806-9282.65.3.460DOI Listing

Subtar arthroscopic debridment for the treatment of sinus tarsi syndrome: case series.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):370-374. Epub 2019 Apr 11.

Department of Orthopedics and Traumatology, Escola Paulista de Medicina, Federal University of São Paulo, SP, Brasil.

Objective: The objective of this study is to report the results of arthroscopic debridement of the subtalar joint in eight patients with Sinus Tarsi Syndrome (STS) refractory to conservative treatment.

Methods: This is a retrospective study of eight patients with STS who underwent subtalar arthroscopy for debridement of the sinus tarsi between January 2015 and January 2017 after six months of conservative treatment. All patients answered an epidemiological questionnaire and underwent functional evaluation with the Visual Analogue Pain Scale (VAS) and the American Orthopedic Foot and Ankle Society Score (AOFAS) in the preoperative and in the last evaluation (average of 12 months - 6-24 months). Read More

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http://dx.doi.org/10.1590/1806-9282.65.3.370DOI Listing

Sample design and participation in the Educatel Study.

Cad Saude Publica 2019 Apr 15;35Suppl 1(Suppl 1):e00167217. Epub 2019 Apr 15.

Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.

Educatel Brazil 2015/2016 was a cross-sectional study conducted by telephone interview with the aim of producing information on health and absenteeism in Brazilian schoolteachers. The nationally representative sampling plan was based on the simple stratified sampling method, with stratification defined to meet the analytical domains established for the study (five major geographic regions, two census areas, four age brackets, sex, three types of school administration, five types of teacher employment, and six grade levels) and selection by simple random sampling of teachers in each stratum. Teacher selection was based on the 2014 School Census conducted by the Brazilian National Institute for Educational Studies and Research "Anísio Teixeira". Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0102-311X00167217DOI Listing
April 2019
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Multiple exposures to the risk of work absenteeism among Brazilian schoolteachers.

Cad Saude Publica 2019 Apr 15;35Suppl 1(Suppl 1):e00166517. Epub 2019 Apr 15.

Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.

The study aimed to identify multiple exposures to the risk of work absenteeism among Brazilian schoolteachers, independently of the reasons reported by teachers (n = 6,510). The data came from a telephone survey on health, working conditions, and absenteeism among schoolteachers in Brazil (Educatel Study, 2015/2016). Exposures were identified and studied by principal components analysis and Poisson regression, with a focus on working conditions and quality of school administration. Read More

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http://dx.doi.org/10.1590/0102-311X00166517DOI Listing

Hypotheses, design, and instruments in the Educatel Study, Brazil, 2015/2016.

Cad Saude Publica 2019 Apr 15;35Suppl 1(Suppl 1):e00108618. Epub 2019 Apr 15.

Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.

The Educatel Study 2015/2016 was designed to evaluate health and work conditions in a representative sample of the 2,220,000 schoolteachers working in Basic Education in Brazil. The article aimed to describe the telephone survey's basis and design, using a questionnaire consisting of 54 short, simple questions, most of which with multiple-choice answers (closed questions) addressing diseases, accidents, absenteeism, frequency of healthy behaviors, physical and psychosocial environment, and employment characteristics. In the pilot stage, the multi-theme questionnaire was assessed in order to verify the effects of the terminology, the format of the questions and the multiple-choice answers, the questionnaire's internal organization, production of the answers, and duration of the interview. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0102-311X00108618DOI Listing
April 2019
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Lessons from schoolteachers on their joys and pains at work.

Cad Saude Publica 2019 Apr 15;35Suppl 1(Suppl 1):e00049018. Epub 2019 Apr 15.

Fundação Jorge Duprat Figueiredo de Segurança e Medicina do Trabalho, São Paulo, Brasil.

Why do schoolteachers get sick? The essay poses this question and points in some directions for answers. After discovering that the most prevalent diseases among Brazilian schoolteachers are the same as those in teachers the world over, the author concluded that the crux of the problem lies in the schoolteachers' work, the constant in the equation. Their work thus needs to be understood better, and their work should be the center of attention. Read More

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http://dx.doi.org/10.1590/0102-311X00049018DOI Listing

Schoolteachers' health in Brazil.

Cad Saude Publica 2019 Apr 15;35Suppl 1(Suppl 1):e00002619. Epub 2019 Apr 15.

Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.

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http://dx.doi.org/10.1590/0102-311X00002619DOI Listing