147,812 results match your criteria Medicina Buenos Aires [Journal]


Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep.

Redox Biol 2019 Jan 29;22:101128. Epub 2019 Jan 29.

Programa de Fisiopatología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Av. Salvador 486, Providencia 7500922, Santiago, Chile; International Center for Andean Studies (INCAS), Universidad de Chile, Baquedano s/n, Putre, Chile. Electronic address:

Chronic hypobaric hypoxia during fetal and neonatal life induces neonatal pulmonary hypertension. Hypoxia and oxidative stress are driving this condition, which implies an increase generation of reactive oxygen species (ROS) and/or decreased antioxidant capacity. Melatonin has antioxidant properties that decrease oxidative stress and improves pulmonary vascular function when administered postnatally. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101128DOI Listing
January 2019

Forms of extracellular mitochondria and their impact in health.

Mitochondrion 2019 Feb 13. Epub 2019 Feb 13.

Universidad San Francisco de Quito, Colegio de Ciencias de la Salud - Hospital de los Valles, Escuela de Medicina, Quito 17-12-841, Ecuador; Universidad San Francisco de Quito, Instituto de Investigaciones en Biomedicina, Quito 17-12-841, Ecuador; Mito-Act Research Consortium, Quito, Ecuador; Sistemas Médicos - Universidad San Francisco de Quito, SIME-USFQ, Quito 17-12-841, Ecuador. Electronic address:

Mitochondria play an important role as an intracellular energy plant and signaling organelle. However, mitochondria also exist outside cells where they could mediate cell-to-cell communication, repair and serve as an activator of the immune response. Their effects depend on the mitochondrial state or the form in which it is present, either as a whole functional structure as fragments or only as mitochondrial DNA. Read More

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http://dx.doi.org/10.1016/j.mito.2019.02.002DOI Listing
February 2019

Cromolyn-crosslinked chitosan nanoparticles for the treatment of allergic rhinitis.

Eur J Pharm Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmacy and Biotechnology, Via San Donato 19/2, University of Bologna, 40127 Bologna, Italy. Electronic address:

The aim of this work was to prepare new mucoadhesive nasal decongestant nanoparticles obtained by direct crosslinking between the cationic polymer chitosan and the anionic drug cromolyn. Different chitosan/cromolyn molar ratios were used in order to obtain nanoparticles of suitable size, encapsulation efficiency/drug loading and mucoadhesion. Moreover, the ability of the nanoparticles to deliver cromolyn into and through the nasal mucosa was evaluated. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.02.015DOI Listing
February 2019

Diabetes and cancer: debating the link through Ca/cAMP signalling.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo, 669, Vila Clementino, São Paulo, SP, Brazil, CEP: 04039-032. Electronic address:

The incidence of both cancer and diabetes is dramatically increasing in worldwide population, costing many millions from governments into expenditures related to medical health systems. Diabetes has been clinically linked to an increased risk for developing several types of cancer. The cellular mechanisms involved in this link are still under intensive debate in literature. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.02.017DOI Listing
February 2019

Radiation dose in nuclear medicine: the hybrid imaging.

Radiol Med 2019 Feb 15. Epub 2019 Feb 15.

Dipartimento di Biomedicina e Prevenzione, Università di Roma Tor Vergata, Rome, Italy.

Hybrid imaging procedures such as single-photon emission computed tomography/computed tomography (SPECT/CT) and positron emission tomography/computed tomography (PET/CT) showed a rapid diffusion in recent years because of their high sensitivity, specificity, and accuracy, due to a more accurate localization and definition of scintigraphic findings. However, hybrid systems inevitably lead to an increase in patient radiation exposure because of the added CT component. Effective doses due to the radiopharmaceuticals can be estimated by multiplying the administered activities by the effective dose coefficients, while for the CT component the dose-length product can be multiplied by a conversion coefficient k. Read More

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http://dx.doi.org/10.1007/s11547-019-00989-yDOI Listing
February 2019

The role of sloths and anteaters as Leishmania spp. reservoirs: a review and a newly described natural infection of Leishmania mexicana in the northern anteater.

Parasitol Res 2019 Feb 15. Epub 2019 Feb 15.

Departamento de Producción Agrícola y Animal, Universidad Autónoma Metropolitana, Calzada del Hueso 1100, Col. Villa Quietud, Del. Coyoacán, C.P. 04960, Mexico City, Mexico.

For years, mammals of the order Pilosa have been considered Leishmania reservoirs. But while most studies have focused on sloth species, anteaters have been overlooked, and in many Leishmania endemic countries like Mexico, no studies have been carried out. The aims of this work were to identify the presence of Leishmania spp. Read More

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http://dx.doi.org/10.1007/s00436-019-06253-6DOI Listing
February 2019

Incidence of perineal pain and dyspareunia following spontaneous vaginal birth: a systematic review and meta-analysis.

Int Urogynecol J 2019 Feb 15. Epub 2019 Feb 15.

Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Introduction And Hypothesis: Perineal pain and dyspareunia are experienced by women undergoing a vaginal birth that can have short and longer term physical and psychological morbidities. This review aimed to determine the incidence of perineal pain and dyspareunia following spontaneous vaginal birth (SVB) with intact perineum, first and second-degree perineal trauma or episiotomy.

Methods: Searches of MEDLINE, EMBASE, CINAHL, AMED and MIDIRS (inception - December 2017) were undertaken with selection criteria of any study evaluating the effect of intact perineum, first- or second-degree perineal trauma on perineal pain or dyspareunia in women with SVB. Read More

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http://dx.doi.org/10.1007/s00192-019-03894-0DOI Listing
February 2019

Synovial fluid leukocyte count in asymptomatic hyperuricaemia with crystal deposition: a proof-of-concept study.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Sección de Reumatología, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Hospital General Universitario de Alicante, Spain.

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http://dx.doi.org/10.1093/rheumatology/kez023DOI Listing
February 2019

scFv6.C4 DNA vaccine with fragment C of Tetanus toxin increases protective immunity against CEA-expressing tumor.

Gene Ther 2019 Feb 15. Epub 2019 Feb 15.

Research Center for Gene Therapy, Escola Paulista de Medicina, Universidade Federal de São Paulo Rua Mirassol, 207 CEP 04044-010, São Paulo, SP, Brazil.

The carcinoembryonic antigen (CEA) is the main tumor-associated antigen of colorectal cancers. Previously, we developed a DNA vaccine using scFv6.C4, a CEA surrogate, against CEA-expressing tumors; 40% of the vaccinated mice were tumor-free after tumor challenge. Read More

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http://dx.doi.org/10.1038/s41434-019-0062-yDOI Listing
February 2019

Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy.

Nat Commun 2019 Feb 15;10(1):797. Epub 2019 Feb 15.

Instituto de Investigaciones Biomédicas "Alberto Sols", CSIC-UAM, 28029, Madrid, Spain.

FXR1 is an alternatively spliced gene that encodes RNA binding proteins (FXR1P) involved in muscle development. In contrast to other tissues, cardiac and skeletal muscle express two FXR1P isoforms that incorporate an additional exon-15. We report that recessive mutations in this particular exon of FXR1 cause congenital multi-minicore myopathy in humans and mice. Read More

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http://dx.doi.org/10.1038/s41467-019-08548-9DOI Listing
February 2019

Fhit-Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells.

Cell Death Dis 2019 Feb 15;10(3):147. Epub 2019 Feb 15.

Department of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, OH, 43210, USA.

Fhit protein is lost in cancers of most, perhaps all, cancer types; when restored, it can induce apoptosis and suppress tumorigenicity, as shown in vitro and in mouse tumor models in vivo. Following protein cross-linking and proteomics analyses, we characterized a Fhit protein complex involved in triggering Fhit-mediated apoptosis. The complex includes the heat-shock chaperonin pair, HSP60/10, which is likely involved in importing Fhit into the mitochondria, where it interacts with ferredoxin reductase, responsible for transferring electrons from NADPH to cytochrome P450 via ferredoxin, in electron transport chain complex III. Read More

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http://dx.doi.org/10.1038/s41419-019-1414-7DOI Listing
February 2019

Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational study.

BMC Ophthalmol 2019 Feb 15;19(1):52. Epub 2019 Feb 15.

Glaucoma Service, Department of Ophthalmology, Federal University of São Paulo, Rua Botucatu, 821, Vila Clementino, São Paulo, 04021-001, Brazil.

Background: To investigate structural and functional correlations in glaucoma patients using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT)-derived parameters.

Methods: We prospectively enrolled healthy participants and glaucomatous patients with a wide range of disease stages. All participants underwent visual field (VF) testing (SITA - Standard 24-2; Carl Zeiss Meditec, Dublin, CA) and EDI OCT imaging (Spectralis; Heidelberg Engineering Co. Read More

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http://dx.doi.org/10.1186/s12886-019-1054-9DOI Listing
February 2019

Structural assessments in decellularized extracellular matrix of porcine semilunar heart valves: Evaluation of cell niches.

Xenotransplantation 2019 Feb 16:e12503. Epub 2019 Feb 16.

Escola de Medicina, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.

Tissue-engineered heart valves aim to reproduce the biological properties of natural valves with anatomically correct structure and physiological performance. The closest alternative to creating an ideal heart valve substitute is to use decellularized porcine heart valves, due to their anatomy and availability. However, the immunological barrier and the structural maintenance limit the long-term physiological performance of decellularized porcine heart valves. Read More

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http://dx.doi.org/10.1111/xen.12503DOI Listing
February 2019

Improvements cardiometabolic risk factors in Latin American Amerindians (the Mapuche) with concurrent training.

Scand J Med Sci Sports 2019 Feb 15. Epub 2019 Feb 15.

Education department of La Unión city, Chile.

Our aim was to investigate the effects of 12-weeks of CT (i.e., high-intensity interval and resistance training) in Mapuche adults from Chile and in their peers of European descent. Read More

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http://dx.doi.org/10.1111/sms.13409DOI Listing
February 2019

Curcumin prevents high glucose damage in retinal pigment epithelial cells through ERK1/2-mediated activation of the Nrf2/HO-1 pathway.

J Cell Physiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, University of Catania, Catania, Italy.

To study the effects of curcumin on human retinal pigment epithelial (RPE) cells exposed to high glucose (HG) insult, we performed in vitro studies on RPE cells cultured both in normal and HG conditions to assess the effects of curcumin on the cell viability, nuclear factor erythroid 2-related factor 2 (Nrf2) expression, HO-1 activity, and ERK1/2 expression. RPE cells exposed to HG insult were treated with curcumin. The cell viability, apoptosis, HO-1 activity, ERK, and Nrf2 expression were evaluated. Read More

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http://doi.wiley.com/10.1002/jcp.28347
Publisher Site
http://dx.doi.org/10.1002/jcp.28347DOI Listing
February 2019
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High-risk human papilloma virus testing improves diagnostic performance to predict moderate-to-high grade anal intraepithelial neoplasia in HIV-infected men who have sex with men in low-to-absent cytological abnormalities.

Clin Infect Dis 2019 Feb 16. Epub 2019 Feb 16.

Unidad Clínica de Enfermedades Infecciosas y Medicina Preventiva (UCEIMP). Hospital Universitario Virgen del Rocío. Seville, Spain.

Background: Screening methods for anal intraepithelial neoplasia (AIN) are suboptimal. This study aimed to determine the diagnostic performance of a composite endpoint comprising anal liquid-based cytology (aLBC) and high-risk human papillomavirus (HR-HPV) testing to predict histological high-grade squamous intraepithelial lesions (HSIL).

Methods: From a cohort of HIV-infected men who have sex with men (MSM) seen at a Spanish University hospital, all individuals who had an aLBC with concomitant HR-HPV testing were included. Read More

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http://dx.doi.org/10.1093/cid/ciz144DOI Listing
February 2019

Targeted assessment of methylation identifies a rapidly recurrent, routinely fatal molecular subtype of adrenocortical carcinoma.

Clin Cancer Res 2019 Feb 15. Epub 2019 Feb 15.

Internal Medicine - Metabolism, Endocrinology & Diabetes, University of Michigan-Ann Arbor

Purpose: Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with few therapies; however, patients with locoregional disease have variable outcomes. The Cancer Genome Atlas project on ACC (ACC-TCGA) identified that cancers of patients with homogeneously rapidly recurrent or fatal disease bear a unique CpG island hypermethylation phenotype, "CIMP-high." We sought to identify a biomarker that faithfully captures this subgroup. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-2693DOI Listing
February 2019

The appointment of an internal medicine practitioner to a neurosurgical department: Advantages, and clinical and professional implications.

Neurocirugia (Astur) 2019 Feb 12. Epub 2019 Feb 12.

Servicio de Neurocirugía, Hospital Universitario de Burgos, Burgos, España.

The increasing age and complexity of in-hospital neurosurgery patients have raised the number of consultations with Internal Medicine. This type of collaboration is discretional and lacks temporal continuity. The full-time appointment of an internal medicine practitioner to a Neurosurgery Department, with complete care attributions except for strict surgical work, is a feasible organizational option. Read More

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http://dx.doi.org/10.1016/j.neucir.2018.12.003DOI Listing
February 2019

Digoxin-specific Fab and therapeutic plasma exchange for digitalis intoxication and renal failure: A case report.

Am J Emerg Med 2019 Jan 22. Epub 2019 Jan 22.

Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Via Manzoni 56, Rozzano, MI, Italy.

Treatment of chronic digitalis intoxication includes suspension of drug intake, which may be sufficient in case of mild manifestations, and supportive measures. Severe bradycardia requires the administration of atropine or isoproterenol; placement of a temporary pacemaker may be required in case of absent response to pharmacological therapy. Severe and life-threatening manifestations should be treated with digoxin-specific fragment antigen binding antibodies (Fab). Read More

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http://dx.doi.org/10.1016/j.ajem.2019.01.038DOI Listing
January 2019

Long-acting injectable antipsychotics (LAIs) for maintenance treatment of bipolar and schizoaffective disorders: A systematic review.

Eur Neuropsychopharmacol 2019 Feb 12. Epub 2019 Feb 12.

Barcelona Bipolar Disorders Program, Hospital Clinic, Institute of Neuroscience, University of Barcelona, IDIBAPS, CIBERSAM, 170 Villarroel st., Barcelona, Catalunya, Spain. Electronic address:

Long-Acting Injectable Antipsychotics (LAIs) are used to overcome non-compliance in psychoses, mainly schizophrenia spectrum disorders. We aimed to summarize available evidence of studies comparing the efficacy of LAIs to placebo or oral medications for Bipolar Disorder (BD) and/or Schizoaffective Disorder (SAD). We searched six databases from inception to 28-March-2018, using the strategy: long-acting antipsychotics AND (bipolar disorder OR schizoaffective disorder OR mania OR manic OR bipolar depression). Read More

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http://dx.doi.org/10.1016/j.euroneuro.2019.02.003DOI Listing
February 2019

Lipid control and associated risk factors, before suffering from the first cardiovascular event.

Clin Investig Arterioscler 2019 Feb 12. Epub 2019 Feb 12.

Atención primaria, Costa de Ponent, Institut Català de la Salut, Barcelona, España.

Objective: To ascertain the degree of lipidic control before the first cardiovascular accident in population attended during 2013 at Primary Care. To analyze the distribution of these events depending on control intervals of cholesterol LDL (LDL-chol), cholesterol HDL (HDL-chol) and triglycerides (TG).

Method: A multicentric cross-sectional, descriptive study on above 18-year-old people attended at the centres of the Primari Care Service (PCS) Baix Llobregat Nord, who had suffered a first cardiac or cerebral ischemic attack from 01/01/2013 to 31/12/2013. Read More

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http://dx.doi.org/10.1016/j.arteri.2018.12.002DOI Listing
February 2019

[Nutritional composition of vending foods of public university and hospital buildings in Asturias].

Aten Primaria 2019 Feb 12. Epub 2019 Feb 12.

Facultad de Medicina y Ciencias de la Salud, Universidad de Oviedo, Campus del Cristo, Oviedo, España.

Objective: To evaluate the nutritional composition of food vending machines (VM) located in university public buildings and hospitals in Asturias.

Design: Descriptive cross-sectional study.

Location: The analysis was made of the contents of VMs located in public buildings, hospitals, and university teaching centres in the Principality of Asturias. Read More

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http://dx.doi.org/10.1016/j.aprim.2018.04.010DOI Listing
February 2019

IL33/ST2 Axis in Diabetic Kidney Disease: A Literature Review.

Medicina (Kaunas) 2019 Feb 14;55(2). Epub 2019 Feb 14.

School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.

Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are expressed in epithelial barrier tissues and endothelial barriers. ST2 is a receptor for IL-33, expressed selectively on a subset of Th2 cells, mediating some of their functions. Read More

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http://dx.doi.org/10.3390/medicina55020050DOI Listing
February 2019

Influence of Eating Schedule on the Postprandial Response: Gender Differences.

Nutrients 2019 Feb 14;11(2). Epub 2019 Feb 14.

Departament de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallès), Spain.

Ingestion of a meal induces conscious sensations depending of the characteristics of the meal and the predisposition of the eater. We hypothesized that the eating schedule plays a conditioning role, specifically, that an extemporaneous meal is less rewarding than when eaten at the habitual schedule. We conducted a randomized parallel trial in 10 women and 10 men comparing the responses to a consistent savoury lunch-type meal (stewed beans) eaten at the habitual afternoon schedule or at an unconventional time in the morning. Read More

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http://dx.doi.org/10.3390/nu11020401DOI Listing
February 2019

Mulinane and Azorellane Diterpenoid Biomarkers by GC-MS from a Representative Apiaceae (Umbelliferae) Species of the Andes.

Molecules 2019 Feb 14;24(4). Epub 2019 Feb 14.

Consultant, Casilla 942, Viña del Mar 2520000, Chile.

Extracts of bled resin from , of the Azorelloideae family from the Andes (>4000 m), were analyzed by gas chromatography-mass spectrometry. The mass spectra of the dominant compounds of the resin and its hydrogenation products were documented. The most abundant compounds were oxygenated diterpenoids, namely mulinadien-20-oic (Δ and Δ) acids, azorell-13-en-20-oic acid, 13α,14β-dihydroxymulin-11-en-20-oic acid, and azorellanol, with a group of azorellenes and mulinadienes. Read More

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http://dx.doi.org/10.3390/molecules24040684DOI Listing
February 2019

Therapeutic potential of melatonin agonists.

Expert Rev Endocrinol Metab 2008 Mar;3(2):269-279

e Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, College of Physicians and Surgeons of Columbia University, 630 West 168th Street - Rm BB813, NY 10032, USA.

Melatonin, a hormone secreted by the pineal gland, has been successfully employed to improve sleep in both normal patients and insomniacs, and for the treatment of circadian rhythm sleep disorders. Melatonergic MT and MT receptors exist in high concentrations in the suprachiasmatic nucleus of the hypothalamus and have been shown to be instrumental for the sleep-promoting and circadian rhythm-regulating effects of melatonin. A lack of consistency among reports on the therapeutic efficacy of melatonin has been attributed to differences in melatonin's bioavailability and the short half-life of the hormone. Read More

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http://dx.doi.org/10.1586/17446651.3.2.269DOI Listing

Early and premature menopause in women with diabetes mellitus Type 2.

Expert Rev Endocrinol Metab 2014 Jul 23;9(4):297-299. Epub 2014 May 23.

b Grupo de Investigación Salud de la Mujer, Asesor internacional, Orquédeas 1068, Dpto 302, Providencia 7510258, Santiago de Chile, Chile.

Those women who have early menopause have major cardiovascular and metabolic risk. The menopause below 40 years of age has been associated to increase in the risk of early beginning of osteoporosis, cardiovascular disease and diabetes mellitus, disorders characterized by hyperglycemia and glucose intolerance due to deficiency of insulin, decrease of the effectiveness of its action or both. The menopausal hormone therapy is the principal therapeutic tool, with the aim to contribute estrogens to suppress the clinical symptomatology and to make a favorably impact on the estrogen-dependent tissues. Read More

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http://dx.doi.org/10.1586/17446651.2014.922863DOI Listing

Increasing the Chances of Natural Conception: Opinion Statement from the the Brazilian Federation of Gynecology and Obstetrics Associations Committee on Endocrine Gynecology.

Rev Bras Ginecol Obstet 2019 Feb 15. Epub 2019 Feb 15.

Faculty of Medical Sciences, Universidade de Pernambuco, Recife, PE, Brazil.

Considering that myths and misconceptions regarding natural procreation spread rapidly in the era of easy access to information and to social networks, adequate counseling about natural fertility and spontaneous conception should be encouraged in any kind of health assistance. Despite the fact that there is no strong-powered evidence about any of the aspects related to natural fertility, literature on how to increase the chances of a spontaneous pregnancy is available. In the present article, the Brazilian Federation of Gynecology and Obstetrics Associations (FEBRASGO, in the Portuguese acronym) Committee on Endocrine Gynecology provides suggestions to optimize counseling for non-infertile people attempting spontaneous conception. Read More

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http://dx.doi.org/10.1055/s-0039-1677838DOI Listing
February 2019

A decision-aid tool for ICU admission triage is associated with a reduction in potentially inappropriate intensive care unit admissions.

J Crit Care 2019 Feb 4;51:77-83. Epub 2019 Feb 4.

Medical Sciences PhD program, Faculdade de Medicina FMUSP, Universidade de São Paulo, Sao Paulo, Brazil; Teaching and Research on Palliative Care Program, Hospital Sirio-Libanes, Sao Paulo, Brazil.

Purpose: Intensive care unit (ICU) admission triage occurs frequently and often involves highly subjective decisions that may lead to potentially inappropriate ICU admissions. In this study, we evaluated the effect of implementing a decision-aid tool for ICU triage on ICU admission decisions.

Methods: This was a prospective, before-after study. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.002DOI Listing
February 2019

Circulating miRNA-126, -145 and -155 levels in Mexican women exposed to inorganic arsenic via drinking water.

Environ Toxicol Pharmacol 2019 Feb 7;67:79-86. Epub 2019 Feb 7.

Laboratorio de Toxicología Molecular, Centro de Investigación Aplicada en Ambiente y Salud (CIAAS), Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico; Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico; Unidad Académica Multidisciplinaria Zona Media, Universidad Autónoma de San Luis Potosí, Rio-verde, San Luis Potosí, Mexico. Electronic address:

The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Mean UAs concentration of 19.5 ± 14. Read More

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http://dx.doi.org/10.1016/j.etap.2019.02.004DOI Listing
February 2019

Corrigendum to "PEGylated ofloxacin nanoparticles render strong antibacterial activity against many clinically important human pathogens" [Colloids Surf. B: Biointerfaces 132 (2015) 62-70].

Colloids Surf B Biointerfaces 2019 Feb 12;177:282-283. Epub 2019 Feb 12.

Centre for the Research and Technology of Agro-Environment and Biological Sciences (CITAB), University of Minho, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.063DOI Listing
February 2019

The use of the Z-scan technique for the determination of biochemical parameters in children with solid tumors or leukemias supplemented or not with selenium.

Photodiagnosis Photodyn Ther 2019 Feb 12. Epub 2019 Feb 12.

Universidade Federal de São Paulo, Instituto de Ciências Ambientais, Químicas e Farmacêuticas. Rua Prof. Arthur Riedel, 275, Jardim Eldorado, 09972-270, Diadema, SP, Brasil; Faculdade de Medicina do ABC, Laboratório de Analises Clínicas. Av. Principe de Gales, 821, 09060-650, Santo André, SP, Brasil.

Cancer is a disease that affects cell metabolism causing an imbalance in the health of the patient. On the other hand, malnutrition, presented by oncological patients, is caused by both the disease and its treatment. Some serum biochemical parameters cannot be determined by the traditional method of laboratory blood analysis (spectrophotometry). Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.012DOI Listing
February 2019

FLEAS ASSOCIATED WITH SIGMODONTINE RODENTS AND MARSUPIALS FROM THE PARANAENSE FOREST IN NORTHEASTERN ARGENTINA.

Acta Trop 2019 Feb 12. Epub 2019 Feb 12.

Centro de Estudios Parasitológicos y de Vectores (CEPAVE) (CONICET CCT La Plata-UNLP), Boulevard 120 s/n e/60 y 64, 1900, La Plata, Argentina. Electronic address:

Fleas from the Paranaense Forest in northeastern Argentina are studied. Herein we provided a list of specimens identified, which includes host species and geographical distribution for each taxa, as well as some comments on the morphology, distribution and epidemiological importance when available. The following eight species and subspecies of fleas belonging to four families were identified: Ctenocephalides felis felis (Pulicidae), Craneopsylla minerva minerva (Stephanocircidae), Polygenis (Polygenis) platensis, Polygenis (Polygenis) roberti beebei, Polygenis (Neopolygenis) pradoi, Polygenis (Neopolygenis) pygaerus (Rhopalopsyllidae), Adoratopsylla (Adoratopsylla) antiquorum antiquorum, and Adoratopsylla (Tritopsylla) intermedia intermedia (Ctenophthalmidae). Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.011DOI Listing
February 2019

Determination of Peptide Profile Consistency and Safety of Collagen Hydrolysates as Quality Attributes.

J Food Sci 2019 Feb 15. Epub 2019 Feb 15.

Unidad de Desarrollo e Investigación en Bioprocesos (UDIBI), Escuela Nacional de Ciencias Biológicas, Insto. Politécnico Nacional, Ciudad de México, 11340, México.

Collagen hydrolysates are dietary supplements used for nutritional and medical purposes. They are complex mixtures of low-molecular-weight peptides obtained from the enzymatic hydrolysis of collagen, which provide intrinsic batch-to-batch heterogeneity. In consequence, the quality of these products, which is related to the reproducibility of their mass distribution pattern, should be addressed. Read More

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http://dx.doi.org/10.1111/1750-3841.14466DOI Listing
February 2019

Spatio-temporal characterization of Trypanosoma cruzi infection and discrete typing units infecting hosts and vectors from non-domestic foci of Chile.

PLoS Negl Trop Dis 2019 Feb 15;13(2):e0007170. Epub 2019 Feb 15.

Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago, Región Metropolitana, Chile.

Background: Trypanosoma cruzi is a protozoan parasite that is transmitted by triatomine vectors to mammals. It is classified in six discrete typing units (DTUs). In Chile, domestic vectorial transmission has been interrupted; however, the parasite is maintained in non-domestic foci. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007170DOI Listing
February 2019

Inflammation status in HIV-positive individuals correlates with changes in bone tissue quality after initiation of ART.

J Antimicrob Chemother 2019 Feb 14. Epub 2019 Feb 14.

Infectious Diseases Department, Hospital del Mar Research Institute, Barcelona, Spain.

Background: The mechanisms behind ART-induced bone changes in HIV-infected patients are poorly known. We aimed to analyse changes in inflammatory and bone markers in HIV after tenofovir disoproxil fumarate initiation, and the associations with changes in the bone strength parameters.

Methods: HIV-positive participants starting tenofovir disoproxil fumarate-based ART underwent dual-energy X-ray absorptiometry (QDR 4500 SL®, Hologic, Waltham, MA, USA) for bone mineral density (BMD), a microindentation test (OsteoProbe®, Active Life Scientific, Santa Barbara, CA, USA) for bone quality [bone material strength index (BMSi)] and phlebotomy at baseline and 48 weeks after ART. Read More

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http://dx.doi.org/10.1093/jac/dkz014DOI Listing
February 2019

Starch as a risk factor for increased trans surgical bleeding in total hip arthroplasty.

Cir Cir 2019 ;87(2):164-169

División de Investigación en Salud, Unidad Médica de Alta Especialidad Dr. Victorio de la Fuente Narváez, IMSS. México.

Objective: Establish whether the use of starch in hip arthroplasty is a risk factor for excessive surgical bleeding and requirement of red blood cell transfusion.

Method: Analytical observational retrospective study in 240 patients who underwent primary total hip arthroplasty from January 2015 to January 2016. Two groups were formed: starch (94 patients) and non-starch (146 patients). Read More

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http://dx.doi.org/10.24875/CIRU.18000397DOI Listing
January 2019

Use of intraoperative cholangiography in patients diagnosed with choledocholithiasis with preoperative imaging or endoscopic study.

Cir Cir 2019 ;87(2):146-150

Servicio de Medicina del Enfermo en Estado Crítico. Hospital San José TecSalud, Monterrey, Nuevo León, México.

Background: Cholecystectomy is one of the most performed procedures worldwide. Many surgeons defend the use of routine intraoperative cholangiography (IOC), but this action is getting less practiced because other preoperative tools that can omit IOC.

Objective: Evaluate the utility of performing intraoperative cholangiography in patients whom got a preoperative imaging or endoscopy study. Read More

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http://dx.doi.org/10.24875/CIRU.18000468DOI Listing
January 2019

Transfixion technique for the treatment of silicone oil pupillary block glaucoma refractory to Nd-YAG iridotomy.

Cir Cir 2019 ;87(2):215-218

Facultad de Medicina, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, México.

Background: Pupillary block induced by silicon oil in vitrectomized patients is a common condition usually treated with Nd-YAG laser iridotomy or with surgical removal of silicon oil.

Case Report: A case of silicone oil pupillary block glaucoma successfully treated with a 30 G needle transfixion technique is described. We performed a non-complicated vitrectomy surgery for retinal detachment with proliferative vitreoretinopathy that included lensectomy, inferior peripheral iridectomy, and silicone oil injection. Read More

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http://www.cirugiaycirujanos.com/frame_esp.php?id=130
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http://dx.doi.org/10.24875/CIRU.18000386DOI Listing
January 2019
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Long-term visual and anatomic outcomes after photodynamic therapy for symptomatic circumscribed choroidal hemangioma.

Cir Cir 2019 ;87(2):224-229

Departamento de Oftalmología. Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, México.

Circumscribed choroidal hemangiomas (CCHs) are relatively rare. We report the response of a symptomatic CCH to photodynamic therapy (PDT). A 70-year-old male presented with blurred vision of the left eye (OS). Read More

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http://dx.doi.org/10.24875/CIRU.18000362DOI Listing
January 2019

Ventriculitis associated with extraventricular drainage: etiology, diagnosis and treatment focused on neurocritic care units.

Cir Cir 2019 ;87(2):230-240

Cartagena Neurotrauma Research Group, Universidad de Cartagena, Cartagena de Indias, Colombia.

Ventriculitis after extraventricular drainage is a very important neurosurgical complication in neurocritical care units. It is necessary to make an early diagnosis, given that the morbidity and mortality secondary to it can be variable, and complicate the evolution of neurocritical patients. Despite this, ventriculostomy continues to be an important pillar in monitoring and treatment. Read More

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http://dx.doi.org/10.24875/CIRU.18000052DOI Listing
January 2019

Protocol for fast postoperative improvement (FPOI) in gastrointestinal surgery.

Cir Cir 2019 ;87(2):151-157

Cátedra de Fisiopatología, Facultad de Farmacia y Bioanálisis, Universidad de Los Andes. Mérida, Venezuela.

Introduction: Peroperative treatment has required multimodal protocols that stimulate patient evolution and shorten hospital stay.

Objective: Identify the type of pathology, intervention performed and evaluate the effectiveness of the Rapid Postoperative Improvement Protocol (RAMPO) in patients undergoing elective gastrointestinal surgery.

Method: A total of 122 patients were evaluated, a group of 61 patients received the RAMPO protocol and the other group of equal number of patients were treated with traditional protocols (Controls). Read More

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http://dx.doi.org/10.24875/CIRU.18000470DOI Listing
January 2019

Abdominal trauma: experience of 4961 cases in Western Mexico.

Cir Cir 2019 ;87(2):183-189

Servicio de Cirugía Medicina Legal, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, México.

Introduction: Trauma is a leading cause of morbimortality in the world. Intraabdominal compartment is the third most affected anatomical region and bleeding from this origin is difficult to identify, therefore the importance to predict possible lesions to the abdominal cavity.

Objective: To describe and analyze the sociodemographic profile and injuries found in patients with abdominal trauma in a western hospital in Mexico. Read More

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http://dx.doi.org/10.24875/CIRU.18000509DOI Listing
January 2019

Recupero degli inadempienti alle vaccinazioni in un centro vaccinale della ASL Roma 2.

Ig Sanita Pubbl 2018 Jul-Aug;74(4):389-397

Dipartimento di Biomedicina e Prevenzione, Università degli studi di Roma "Tor Vergata", Italia.

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February 2019

DEPDC5 mutation and familial focal epilepsy with variable foci: genotype and phenotype of a family.

Epileptic Disord 2019 Feb 15. Epub 2019 Feb 15.

Division of Neuropediatrics, Italian Hospital of Buenos Aires, CABA.

Familial focal epilepsy with variable foci is a relatively rare autosomal disease with an unclear incidence, which is characterized by focal seizures arising from different cortical regions in different family members. We describe three members of a two-generation Argentine family with familial focal epilepsy with variable foci syndrome and a DEPDC5 gene mutation. The mean onset age was nine years old. Read More

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http://dx.doi.org/10.1684/epd.2019.1025DOI Listing
February 2019

Mycobacterium saskatchewanense strain associated with a chronic kidney disease patient in an Italian transplantation hospital and almost misdiagnosed as Mycobacterium tuberculosis.

Infect Control Hosp Epidemiol 2019 Feb 15:1-2. Epub 2019 Feb 15.

Unità di Medicina Rigenerativa e Biotecnologie Avanzate,Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione,Palermo,Italy.

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http://dx.doi.org/10.1017/ice.2019.6DOI Listing
February 2019

Burden of paraquat poisoning in the department of Antioquia, Colombia.

BMC Pharmacol Toxicol 2019 Feb 15;20(1):11. Epub 2019 Feb 15.

Grupo de Investigación en farmacología y toxicología, Centro de Información y Estudio de Medicamentos y Tóxicos (CIEMTO), Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.

Background: Paraquat (PQ) poisoning is a public health problem in many regions of Colombia. This study aimed to estimate the burden of PQ poisoning in the Department of Antioquia, Colombia.

Methods: Disability-adjusted life year (DALYs) were calculated as the sum of years of life lost (YLL) and years of life lived with disability (YLD) due to paraquat poisoning in Antioquia; a bootstrapped method with 1000 iterations was used to estimate each statistical parameter using the package DALY calculator in R. Read More

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http://dx.doi.org/10.1186/s40360-019-0291-0DOI Listing
February 2019

PTX3 Polymorphisms Influence Cytomegalovirus Reactivation After Stem-Cell Transplantation.

Front Immunol 2019 31;10:88. Epub 2019 Jan 31.

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.

Reactivation of latent human cytomegalovirus (CMV) in patients undergoing allogeneic stem-cell transplantation (HSCT) predisposes to several clinical complications and is therefore a major cause of morbidity and mortality. Although pentraxin-3 (PTX3) has been previously described to bind both human and murine CMV and mediate several host antiviral mechanisms, whether genetic variation in the locus influences the risk of CMV infection is currently unknown. To dissect the contribution of genetic variation within to the development of CMV infection, we analyzed described loss-of-function variants at the locus in 394 recipients of HSCT and their corresponding donors and assessed the associated risk of CMV reactivation. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365436PMC
January 2019

Punctal Plug as a Treatment Option for Dry Eye Associated with Congenital Supernumary Puncta.

Middle East Afr J Ophthalmol 2018 Jul-Dec;25(3-4):170-172

Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto-University of São Paulo, Brazil.

This study aims to describe a case of double lower lacrimal punctum-canaliculi in a dry eye patient treated with a punctal plug. A 60-year-old healthy female presented with complaints of tearing, itchy eyes, and foreign body sensation in the right eye for many years. There was no history of trauma or inflammation. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_102_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348943PMC
February 2019

Brivanib in combination with Notch3 silencing shows potent activity in tumour models.

Br J Cancer 2019 Feb 15. Epub 2019 Feb 15.

Center for Applied Biomedical Research (CRBA), S.Orsola-Malpighi University Hospital, Bologna, Italy.

Background: Sorafenib is the first targeted agent proven to improve survival of patients with advanced hepatocellular carcinoma (HCC) and it has been used in first line treatments with heterogeneous response across patients. Most of the promising agents evaluated in first-line or second-line phase III trials for HCC failed to improve patient survival. The absence of molecular characterisation, including the identification of pathways driving resistance might be responsible for these disappointing results. Read More

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http://dx.doi.org/10.1038/s41416-018-0375-4DOI Listing
February 2019