150,029 results match your criteria Medicina Buenos Aires [Journal]


Proteomic characterization of human sperm plasma membrane-associated proteins and their role in capacitation.

Andrology 2019 Apr 19. Epub 2019 Apr 19.

Departamento de Biología de la Reproducción Dr. Carlos Gual Castro, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.

Background: Plasma membranes of ejaculated sperm are covered by epididymal and accessory glands secreted proteins that must be released from sperm surface during the female reproductive tract passage in order to capacitate and fertilize the oocyte.

Objectives: As human sperm plasma membrane-associated proteins (SMAP) have not yet been investigated, the aim of this study was to characterize the SMAP released during in vitro human capacitation and to study their possible role as decapacitation factors.

Materials And Methods: SMAP were characterized by 2-dimensional electrophoresis and mass spectrometry analysis. Read More

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http://dx.doi.org/10.1111/andr.12627DOI Listing

Dopamine drives binge-like consumption of a palatable food in experimental Parkinsonism.

Mov Disord 2019 Apr 19. Epub 2019 Apr 19.

Laboratorio di Neurofisiologia, IRCCS Fondazione Santa Lucia, Rome, Italy.

Background: Prolonged dopaminergic replacement therapy in PD results in pulsatile dopamine receptors stimulation in both dorsal and ventral striatum causing wearing off, motor fluctuations, and nonmotor side effects such as behavioral addictions. Among impulse control disorders, binge eating can be easily modeled in laboratory animals.

Objectives: We hypothesize that manipulation of dopamine levels in a 6-hydroxydopamine-lesioned rats, as a model of PD characterized by a different extent of dopamine denervation between dorsal and ventral striatum, would influence both synaptic plasticity of the nucleus accumbens and binge-like eating behavior. Read More

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http://dx.doi.org/10.1002/mds.27683DOI Listing

Lithium ameliorates tubule-interstitial injury through activation of the mTORC2/protein kinase B pathway.

PLoS One 2019 19;14(4):e0215871. Epub 2019 Apr 19.

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Tubule-interstitial injury (TII) is a critical step in the progression of renal disease. It has been proposed that changes in proximal tubule (PT) albumin endocytosis plays an important role in the development of TII. Some reports have shown protective effects of lithium on kidney injury animal models that was correlated to proteinuria. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215871PLOS

Genetic diversity and zoonotic potential of rotavirus A strains in the southern Andean highlands, Peru.

Transbound Emerg Dis 2019 Apr 19. Epub 2019 Apr 19.

Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil, 21.941-902.

Interspecies transmission is an important mechanism of evolution and contributes to RVA diversity. In order to evaluate the detection frequency, genetic diversity, epidemiological characteristics, and zoonotic potential of rotavirus A (RVA) strains in fecal specimens from humans and animals cohabiting in the same environment in the department of Cusco, Peru, by molecular analysis, 265 fecal specimens were obtained from alpacas, llamas, sheep, and shepherd children, and tested for RVA by RT-PCR. Genotyping was performed by multiplex PCR and sequence analysis. Read More

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http://dx.doi.org/10.1111/tbed.13207DOI Listing

Patterns of Sexual Risk Behavior, HIV Infection, and Use of Health Services Among Sub-Saharan African Migrants in Portugal.

J Sex Res 2019 Apr 19:1-9. Epub 2019 Apr 19.

c Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT , Universidade Nova de Lisboa, UNL.

This study identified patterns of sexual risk behavior among a sub-Saharan African migrant (SAM) population in Portugal and examined its associations with human immunodeficiency virus (HIV) prevalence, sociodemographics, use of sexual health services, and HIV testing. A cross-sectional biobehavioral survey was conducted with a venue-based sample of 790 SAMs. Data were collected using questionnaires and rapid HIV tests. Read More

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http://dx.doi.org/10.1080/00224499.2019.1601154DOI Listing

Spread of the serotypes and antimicrobial resistance in strains of Salmonella spp. isolated from broiler.

Braz J Microbiol 2019 Apr 18. Epub 2019 Apr 18.

Laboratório de Biotecnologia Animal Aplicada, Faculdade de Medicina Veterinária, Universidade Federal de Uberlândia, Rua Ceará, s/n, Bloco 2D, Sala 43, Campus Umuarama, Uberlândia, MG, Brazil.

Serotypes and antimicrobial susceptibility of Salmonella's isolates from broiler production chain were determined. A total of 239 isolated strains from chicken, carcasses, breeding environments, and slaughter was analyzed by disk diffusion test, in the period of 2009 to 2010. For antibiotics with a high number of resistant strains, the minimal inhibitory concentration (MIC) was performed. Read More

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http://dx.doi.org/10.1007/s42770-019-00054-wDOI Listing

Incidence and Risk Factors for Cholelithiasis After Bariatric Surgery.

Obes Surg 2019 Apr 17. Epub 2019 Apr 17.

Bariatric and Metabolic Surgery Center, DIPRECA Hospital, Vital Apoquindo 1200, Las Condes, Santiago, Chile.

Background: Obesity and rapid weight loss after bariatric surgery (BS) are independent risk factors for development of cholelithiasis (CL), a prevalent disease in the Chilean population. This study aimed to determine the incidence of CL in obese Chilean patients 12 months after BS and identify risk factors for development of gallstones.

Methods: Retrospective study of patients who underwent BS in 2014. Read More

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http://dx.doi.org/10.1007/s11695-019-03760-4DOI Listing

Increased phagocytosis and growth inhibition of Encephalitozoon cuniculi by LPS-activated J774A.1 murine macrophages.

Parasitol Res 2019 Apr 18. Epub 2019 Apr 18.

Facultad de Medicina Veterinaria y Zootecnia, Departamento de Inmunología Veterinaria, Campus de Agricultura y Ciencias Biológicas, Universidad Autónoma de Nuevo León, Francisco Villa S/N, Colonia Ex-Hacienda el Canadá, CP 66050, Escobedo, Nuevo León, Mexico.

Encephalitozoon cuniculi is an obligate macrophage parasite of vertebrates that commonly infects rodents, monkeys, dogs, birds, and humans. In the present study, we aimed to assess the phagocytosis and intracellular survival of E. cuniculi spores using untreated and lipopolysaccharide (LPS)-activated J774A. Read More

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http://dx.doi.org/10.1007/s00436-019-06310-0DOI Listing

Pediatric Patients With Steroid-Sensitive Nephrotic Syndrome Have Higher Expression of T Regulatory Lymphocytes in Comparison to Steroid-Resistant Disease.

Front Pediatr 2019 2;7:114. Epub 2019 Apr 2.

Unidade de Nefrologia Pediátrica, Departamento de Pediatria, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

Idiopathic nephrotic syndrome (INS) is classified according to the response to drug therapy in steroid-sensitive (SS), steroid-dependent (SD), and steroid-resistant (SR) categories. Previous studies showed changes in inflammatory activity of subpopulations of lymphocytes in INS. This study aimed to compare SS and SR patients in regard to subpopulations of leukocytes, profile of regulatory lymphocytes, and migratory activity of lymphocyte subpopulations. Read More

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http://dx.doi.org/10.3389/fped.2019.00114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455073PMC

Recent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition.

Front Cell Infect Microbiol 2019 2;9:74. Epub 2019 Apr 2.

Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina, Universidade de Brasília, Brasília, Brazil.

Antimicrobial resistance constitutes one of the major challenges facing humanity in the Twenty-First century. The spread of resistant pathogens has been such that the possibility of returning to a pre-antibiotic era is real. In this scenario, innovative therapeutic strategies must be employed to restrict resistance. Read More

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http://dx.doi.org/10.3389/fcimb.2019.00074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454102PMC

Fracture Healing Monitoring by Impact Tests: Single Case Study of a Fractured Tibia With External Fixator.

IEEE J Transl Eng Health Med 2019 15;7:2100206. Epub 2019 Mar 15.

Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e ChirurgiaUniversità di Pisa56122PisaItaly.

The correct evaluation of the healing process is important to define proper times of fixator dynamization and removal, avoiding refractures. Unfortunately, a quantitative healing assessment is not yet available in clinical practice. The aim of the paper is to prove the feasibility of the mechanical vibration method to assess bone healing in fractures treated with external fixation, in conditions. Read More

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https://ieeexplore.ieee.org/document/8667865/
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http://dx.doi.org/10.1109/JTEHM.2019.2901455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467180PMC
March 2019
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Recent advances in managing/understanding the metabolic syndrome.

F1000Res 2019 3;8. Epub 2019 Apr 3.

Unidad de Investigación en Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, 14008, Mexico.

The metabolic syndrome (MetS) concept gathers in a single entity a set of metabolic abnormalities that have in common a close relationship with ectopic deposit of lipids, insulin resistance, and chronic low-grade inflammation. It is a valuable teaching tool to help health professionals to understand and integrate the consequences of lipotoxicity and the adverse metabolic consequences of insulin resistance. Also, it is useful to identify subjects with a high risk for having incident type 2 diabetes. Read More

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https://f1000research.com/articles/8-370/v1
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http://dx.doi.org/10.12688/f1000research.17122.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449786PMC
April 2019
1 Read

Dentin-pulp complex reactions in conventional and radiation-related caries: A comparative study.

J Clin Exp Dent 2019 Mar 1;11(3):e236-e243. Epub 2019 Mar 1.

Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas (UNICAMP), Piracicaba, São Paulo, Brasil.

Background: Radiation-related caries (RRC) is one of the most significant oral toxicities of head and neck radiotherapy (HNRT); however, the potential of radiation to directly cause harmful dentin and pulpal effects and impair response to caries progression is controversial.

Material And Methods: Therefore, the aim of this study was to characterize the reactions of the dentin-pulp complex in teeth affected by RRC. Patients and methods: Twenty-two carious teeth extracted from 22 head and neck cancer (HNC) patients were divided into control (conventional caries; n=11) and irradiated (RRC; n=11) groups and paired matched by dental homology, clinical patterns of caries progression following the Post-Radiation Dental Index (PRDI) and microscopic depth of carious invasion. Read More

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http://dx.doi.org/10.4317/jced.55370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461726PMC

Nephroprotective Effect of Embryonic Stem Cells Reducing Lipid Peroxidation in Kidney Injury Induced by Cisplatin.

Oxid Med Cell Longev 2019 14;2019:5420624. Epub 2019 Mar 14.

Escuela Militar de Medicina, Centro Militar de Ciencias de la Salud, Secretaria de la Defensa Nacional, Ciudad de México 11200, Mexico.

Introduction: The acute kidney injury (AKI) is characterized by a sudden glomerular filtration reduction. Renal or intrinsic causes of AKI include nephrotoxicity induced by exogenous agents like cisplatin, which causes oxidative stress altering the biochemical process and leading to apoptosis. Therefore, this research is aimed at analyzing the embryonic stem cells (ESC) nephroprotective effect in AKI induced by cisplatin, employing genetic, phenotypic, and microspectroscopic techniques. Read More

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http://dx.doi.org/10.1155/2019/5420624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437739PMC
March 2019
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Akt/AS160 Signaling Pathway Inhibition Impairs Infection by Decreasing Rab14-Controlled Sphingolipids Delivery to Chlamydial Inclusions.

Front Microbiol 2019 3;10:666. Epub 2019 Apr 3.

Laboratorio de Bioquímica e Inmunidad, Área de Química Biológica, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.

, an obligate intracellular bacterium, intercepts different trafficking pathways of the host cell to acquire essential lipids for its survival and replication, particularly from the Golgi apparatus via a Rab14-mediated transport. Molecular mechanisms underlying how these bacteria manipulate intracellular transport are a matter of intense study. Here, we show that utilizes Akt/AS160 signaling pathway to promote sphingolipids delivery to the chlamydial inclusion through Rab14-controlled vesicular transport. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456686PMC

Transcriptome and Proteome Response of Tick Vector to Infection.

Front Physiol 2019 2;10:318. Epub 2019 Apr 2.

Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal.

A system biology approach was used to gain insight into tick biology and interactions between vector and pathogen. is one of the main vectors of which has a massive impact on animal health. It is vital to obtain more information about this relationship, to better understand tick and pathogen biology, pathogen transmission dynamics, and new potential control approaches. Read More

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http://dx.doi.org/10.3389/fphys.2019.00318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454348PMC

Roles, Actions, and Therapeutic Potential of Specialized Pro-resolving Lipid Mediators for the Treatment of Inflammation in Cystic Fibrosis.

Front Pharmacol 2019 2;10:252. Epub 2019 Apr 2.

Department of Medical, Oral and Biotechnological Science, Università "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.

Non-resolving inflammation is the main mechanism of morbidity and mortality among patients suffering from cystic fibrosis (CF), the most common life-threatening human genetic disease. Resolution of inflammation is an active process timely controlled by endogenous specialized pro-resolving lipid mediators (SPMs) produced locally in inflammatory loci to restrain this innate response, prevent further damages to the host, and permit return to homeostasis. Lipoxins, resolvins, protectins, and maresins are SPM derived from polyunsaturated fatty acids that limit excessive leukocyte infiltration and pro-inflammatory signals, stimulate innate microbial killing, and enhance resolution. Read More

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http://dx.doi.org/10.3389/fphar.2019.00252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454233PMC

Quantifying the Magnitude of Pharyngeal Obstruction During Sleep Using Airflow Shape.

Eur Respir J 2019 Apr 18. Epub 2019 Apr 18.

Division of Sleep and Circadian Disorders, Department of Medicine, Brigham & Women's Hospital & Harvard Medical School, Boston, MA, USA.

Rationale: Non-invasive quantification of the severity of pharyngeal airflow obstruction would enable recognition of obstructive central manifestation of sleep apnoea, and identification of symptomatic individuals with severe airflow obstruction despite a low apnoea-hypopnoea index (AHI).

Objectives: Here we provide a novel method that uses simple airflow--time ("shape") features from individual breaths on an overnight sleep study to automatically and non-invasively quantify the of airflow obstruction without oesophageal catheterisation.

Methods: 41 individuals with suspected/diagnosed obstructive sleep apnoea (AHI range=0-91 events·hr) underwent overnight polysomnography with gold-standard measures of airflow (oronasal pneumotach, ) and ventilatory drive (calibrated intraoesophageal diaphragm EMG, ). Read More

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02262
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http://dx.doi.org/10.1183/13993003.02262-2018DOI Listing
April 2019
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Draft Genome Sequence of Paraburkholderia sp. UYCP14C, a Rhizobium Strain Isolated from Root Nodules of Calliandra parvifolia.

Microbiol Resour Announc 2019 Apr 18;8(16). Epub 2019 Apr 18.

Departmento de Bioquímica y Genómica Microbianas, Instituto de Investigaciones Biológicas Clemente Estable, MEC, Montevideo, Uruguay

Here, we present the draft genome sequence of strain UYCP14C, a rhizobium isolated from nodules. The assembled genome size was around 9.8 million bp, containing 9,031 predicted protein-coding sequences, including several symbiotic and nitrogen fixation genes. Read More

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http://dx.doi.org/10.1128/MRA.00173-19DOI Listing

Draft Genome Sequence of Multidrug-Resistant Enterococcus faecium Strain E1298, with a Sequence Type 1274 Profile, Recovered from the Cloacal Microbiome of a Tropical Screech Owl (Megascops choliba) in Rio de Janeiro, Brazil.

Microbiol Resour Announc 2019 Apr 18;8(16). Epub 2019 Apr 18.

Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

Here, we present the draft genome sequence of strain E1298, a representative of the clonal complex 17 (CC17), identified as sequence type 1274 (ST1274) and resistant to multiple classes of antimicrobials, isolated from the cloaca of a tropical screech owl () in Rio de Janeiro, Brazil. Read More

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http://genomea.asm.org/lookup/doi/10.1128/MRA.00168-19
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http://dx.doi.org/10.1128/MRA.00168-19DOI Listing
April 2019
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Genomic Islands in the Full-Genome Sequence of an NAD-Hemin-Independent Avibacterium paragallinarum Strain Isolated from Peru.

Microbiol Resour Announc 2019 Apr 18;8(16). Epub 2019 Apr 18.

Laboratorios de Investigación y Desarrollo, FARVET, Chincha Alta, Ica, Peru.

Here, we report the full-genome sequence of an NAD-hemin-independent serovar C-2 strain, FARPER-174, isolated from layer hens in Peru. This genome contained 12 potential genomic islands that include ribosomal protein-coding genes, a gene, hemocin-coding genes, sequences of fagos, an operon, and drug resistance genes. Read More

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http://dx.doi.org/10.1128/MRA.00118-19DOI Listing

Anatomical Correlation of the Helical Structure of the Ventricular Myocardium Through Echocardiography.

Rev Esp Cardiol (Engl Ed) 2019 Apr 15. Epub 2019 Apr 15.

Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, Mexico. Electronic address:

Introduction And Objectives: The helical structure of the ventricular myocardium provides a simple view of cardiac anatomy, based on physiological evidence that has been broadly demonstrated in experimental and imaging studies, and helps to explain the electromechanical contraction of the myocardium during the cardiac cycle. The aim of this study was to standardize and provide a detailed description of the technique for preparing and manually dissecting the myocardium proposed empirically by Torrent-Guasp. A further aim was to anatomically and topographically correlate the helical band with echocardiographic long-axis, short-axis, and 4-chamber projections. Read More

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http://dx.doi.org/10.1016/j.rec.2018.10.016DOI Listing

Double-balloon enteroscopy: Experience with an innovative endoscopic technique at the Hospital Universitario de la Fundación Santa Fe de Bogotá.

Rev Gastroenterol Mex 2019 Apr 15. Epub 2019 Apr 15.

Departamento de Medicina Interna, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, D.C., Colombia.

Introduction And Aims: Double-balloon enteroscopy is a recently introduced endoscopic method that enables complete visualization of the small bowel, as well as biopsy sampling and therapeutic interventions in that part of the intestine. The aim of the present study was to describe the experience acquired at our hospital to determine the characteristics of the patients that underwent the procedure.

Materials And Methods: A descriptive, cross-sectional study was conducted on all patients above 18 years of age admitted to the Hospital Universitario de la Fundación Santa Fe de Bogotá for double-balloon enteroscopy, within the time frame of January 2013 to December 2017. Read More

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http://dx.doi.org/10.1016/j.rgmx.2019.01.001DOI Listing

Upper Airway Video Endoscopy: Assessment of the response to positive pressure ventilation and mechanical in-exsufflation.

Pulmonology 2019 Apr 15. Epub 2019 Apr 15.

Faculdade de Medicina da Universidade do Porto, Porto, Portugal.

Upper airways (UA) include the nasal cavities, pharynx, and larynx, and its main function is to warm and filter the inspired air. UA dysfunction is in the pathogenesis of various disorders, such as obstructive sleep apnea syndrome (OSAS) and vocal cord dysfunction. In addition, in some neurodegenerative diseases (e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S25310437193004
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http://dx.doi.org/10.1016/j.pulmoe.2019.02.008DOI Listing
April 2019
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Tarlov cyst: A rare cause of posterior mediastinal mass.

Pulmonology 2019 Apr 15. Epub 2019 Apr 15.

Departamento de Radiologia da Faculdade de Medicina da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.pulmoe.2019.03.001DOI Listing

Association Between Subglottic Pressure and Pulmonary Function in Individuals With Parkinson's Disease.

J Voice 2019 Apr 15. Epub 2019 Apr 15.

Facultad de Ciencias de la Rehabilitacion, Universidad Andres Bello, Santiago, Chile. Electronic address:

Introduction: In individuals with Parkinson's disease (PD), pulmonary complication such as weakness and rigidity of respiratory muscles and reduced cough airflow may be associated with reduced voice production due to limited pulmonary capacity and reduced airflow needed to vibrate the vocal folds. It is not clear, however, which pulmonary function parameter is determinant in the association with peak subglottic pressure (SGP). Therefore, the purpose of this study was to determine the association between peak SGP and pulmonary function parameters in individuals with PD. Read More

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http://dx.doi.org/10.1016/j.jvoice.2019.03.001DOI Listing

[Does the new law grant the desired autonomy for our patients?]

J Healthc Qual Res 2019 Apr 15. Epub 2019 Apr 15.

Servicio de Medicina Intensiva, Hospital Universitario Marqués de Valdecilla, Santander, España; Presidente del Comité de Ética Asistencial, Hospital Universitario Marqués de Valdecilla, Santander, España.

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http://dx.doi.org/10.1016/j.jhqr.2019.01.005DOI Listing

Wrist drop in an arcade dancing game: Unusual sudden bilateral radial palsy.

Neuromuscul Disord 2019 Feb 19. Epub 2019 Feb 19.

Departamento de Ciencias Neurológicas, Facultad de Medicina, Universidad de Chile, Avda Infante 553, Providencia, Santiago, Chile.

Bilateral simultaneous radial palsy is uncommon, and the few cases reported in the literature are due to compressive injuries, such as in the use of axillary crutch or birthing bar during labor. We present a patient who developed a severe bilateral palsy after playing in a dancing simulator machine. The patient's position during the game was a combination of wrist extension, elbow flexion, retroversion of arms and a degree of minor torsion of both upper limbs. Read More

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http://dx.doi.org/10.1016/j.nmd.2019.02.005DOI Listing
February 2019

[Influence of diagnostic pathway on clinical and non-conventional therapies use in women with breast cancer of the cohort DAMA].

Gac Sanit 2019 Apr 15. Epub 2019 Apr 15.

Agència de Salut Pública de Barcelona, Barcelona, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España; Institut de Recerca Biomèdica Sant Pau, Barcelona, España.

Objective: To describe and analyze the characteristics of breast cancer tumours according to the diagnostic pathway. We analyse the adverse effects of the treatments and the use of unconventional therapies in order to alleviate them.

Method: Descriptive design nested in a mixed cohort (Cohort DAMA). Read More

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http://dx.doi.org/10.1016/j.gaceta.2019.02.006DOI Listing

Coexistence of variants in TBK1 and in other ALS-related genes elucidates an oligogenic model of pathogenesis in sporadic ALS.

Neurobiol Aging 2019 Mar 27. Epub 2019 Mar 27.

Centro Clinico NEMO, Roma, Italy; Dipartimento Scienze dell'invecchiamento, Neurologiche, Ortopediche e della testa-collo, Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC Neurologia, Roma, Italy; Università Cattolica del Sacro Cuore, Istituto di Neurologia, Roma, Italy. Electronic address:

Variants in tank-binding kinase 1 (TBK1) are responsible for a significant proportion of amyotrophic lateral sclerosis (ALS) cases. In the present study, we analyzed variants in TBK1 extracted by targeted sequencing of 32 genes in a group of 406 Italian patients with ALS. We identified 7 different TBK1 variants in 7 sporadic cases, resulting in a frequency of 1. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.03.010DOI Listing

Reduction in the number of inadequate prescriptions: Pharmacy-prescriber communication.

Authors:
J Ena

Rev Clin Esp 2019 Apr 15. Epub 2019 Apr 15.

Servicio de Medicina Interna, Hospital Marina Baixa, La Vila Joiosa, Alicante, España. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00142565193008
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http://dx.doi.org/10.1016/j.rce.2019.03.001DOI Listing
April 2019
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Multielectrode Mapping and Pattern Matching Recognition for Left Premature Ventricular Contraction Ablation.

JACC Clin Electrophysiol 2019 Apr;5(4):528-529

Pacing and Electrophysiology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal.

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https://linkinghub.elsevier.com/retrieve/pii/S2405500X183098
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http://dx.doi.org/10.1016/j.jacep.2018.11.019DOI Listing
April 2019
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Tuberculosis care for migrant patients in Portugal: a mixed methods study with primary healthcare providers.

BMC Health Serv Res 2019 Apr 18;19(1):233. Epub 2019 Apr 18.

Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Rua da Junqueira 100, 1349-008, Lisbon, Portugal.

Background: Tuberculosis (TB) is still a major global health problem. The increasing number of cases observed among foreign-born populations contrasts with the decreasing trends observed in later years in some high-income countries. Healthcare providers are key interveners in the control of TB and HIV-TB infections. Read More

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http://dx.doi.org/10.1186/s12913-019-4050-0DOI Listing

Immune reconstitution inflammatory syndrome associated with secondary syphilis: dermatologic, neurologic and ophthalmologic compromise in an HIV patient.

Int J STD AIDS 2019 Apr 10;30(5):509-511. Epub 2019 Jan 10.

1 Servicio de Enfermedades Infecciosas y Tropicales. Hospital Nacional Dos de Mayo, Lima, Peru.

The presentation of syphilis as a manifestation of immune reconstitution inflammatory syndrome in patients with human immunodeficiency virus (HIV) infection is rare and can be associated with the varied clinical expression of unusual syphilitic manifestations. We report a case of immune reconstitution syndrome with dermatologic, ophthalmologic and neurologic compromise of secondary syphilis in a patient with HIV infection. Read More

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http://dx.doi.org/10.1177/0956462418813045DOI Listing

The pathogenic microbial flora and its antibiotic susceptibility pattern in odontogenic infections.

Drug Metab Rev 2019 Apr 18:1-46. Epub 2019 Apr 18.

a Universitatea din Oradea Facultatea de Medicina si Farmacie, Dental Medicine , Oradea , 410073 Romania.

Suppurative head and neck infections of odontogenic origin are the most frequent type of head and neck infections. According to the literature, 7-10% of all antibiotics are currently prescribed for their treatment. Since penicillin was invented, the overall antibiotic sensitivity and resistance pattern of the isolated pathogenic microflora has continuously changed. Read More

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http://dx.doi.org/10.1080/03602532.2019.1602630DOI Listing

Synergistic Effects of Plant Derivatives and Conventional Chemotherapeutic Agents: An Update on the Cancer Perspective.

Medicina (Kaunas) 2019 Apr 17;55(4). Epub 2019 Apr 17.

Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.

Synergy is a process in which some substances cooperate to reach a combined effect that is greater than the sum of their separate effects. It can be considered a natural "straight" strategy which has evolved by nature to obtain more efficacy at low cost. In this regard, synergistic effects may be observed in the interaction between herbal products and conventional drugs or biochemical compounds. Read More

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http://dx.doi.org/10.3390/medicina55040110DOI Listing

The Quality of Life of Patients with Surgically Treated Mandibular Fractures and the Relationship of the Posttraumatic Pain and Trismus with the Postoperative Complications: A Prospective Study.

Medicina (Kaunas) 2019 Apr 17;55(4). Epub 2019 Apr 17.

Primary Health Care Center, 20000 Podgorica, Montenegro.

Due to the fact that the mandible is the only movable bone in the face, it is often exposed to the influence of external forces. The incidence of trismus and posttraumatic pain in unilateral mandibular corpus fractures may be related to the occurrence of complications. There is a decrease in the quality of life of these patients. Read More

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https://www.mdpi.com/1010-660X/55/4/109
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http://dx.doi.org/10.3390/medicina55040109DOI Listing
April 2019
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Effects of Neck Taping in the Treatment of Hemispatial Neglect in Chronic Stroke Patients: A Pilot, Single Blind, Randomized Controlled Trial.

Medicina (Kaunas) 2019 Apr 17;55(4). Epub 2019 Apr 17.

Neuromotor and Cognitive Rehabilitation Research Center, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.

Hemispatial neglect is a common consequence of stroke, with an estimated incidence of 23%. Interventions for treating hemispatial neglect may be categorized as either top-down or bottom-up processing. The aim of top-down approaches is to train the person to voluntarily compensate for their neglect. Read More

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https://www.mdpi.com/1010-660X/55/4/108
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http://dx.doi.org/10.3390/medicina55040108DOI Listing
April 2019
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Is There A Role for Abscisic Acid, A Proven Anti-Inflammatory Agent, in the Treatment of Ischemic Retinopathies?

Antioxidants (Basel) 2019 Apr 17;8(4). Epub 2019 Apr 17.

Universitat Jaume I, Unitat predepartamental de Medicina, Avda/Sos Baynat, S/N, 12071 Castellón de la Plana, Spain.

Ischemic retinopathies (IRs) are the main cause of severe visual impairment and sight loss, and are characterized by loss of blood vessels, accompanied by hypoxia, and neovascularization. Actual therapies, based on anti-vascular endothelial growth factor (VEGF) strategies, antioxidants or anti-inflammatory therapies are only partially effective or show some adverse side effects. Abscisic acid (ABA) is a phytohormone present in vegetables and fruits that can be naturally supplied by the dietary intake and has been previously studied for its benefits to human health. Read More

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https://www.mdpi.com/2076-3921/8/4/104
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http://dx.doi.org/10.3390/antiox8040104DOI Listing
April 2019
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Physiological Responses of Jurkat Lymphocytes to Simulated Microgravity Conditions.

Int J Mol Sci 2019 Apr 17;20(8). Epub 2019 Apr 17.

Department of Neuroscience, Imaging and Clinical Sciences, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.

The presence of microgravity conditions deeply affects the human body functions at the systemic, organ and cellular levels. This study aimed to investigate the effects induced by simulated-microgravity on non-stimulated Jurkat lymphocytes, an immune cell phenotype considered as a biosensor of the body responses, in order to depict at the cellular level the effects of such a peculiar condition. Jurkat cells were grown at 1 g or on random positioning machine simulating microgravity. Read More

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http://dx.doi.org/10.3390/ijms20081892DOI Listing

Management of CPAP-Induced Ocular Air Reflux Due to a Porous Polyethylene-Coated Lester Jones Tube.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):419-421. Epub 2019 Apr 18.

Department of Oculoplastic Surgery, Hospital Sao Geraldo, Universidade Federal de Minas Gerais Faculdade de Medicina, Belo Horizonte, Brazil.

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http://dx.doi.org/10.1055/a-0799-9777DOI Listing

The effect of nitric oxide on mitochondrial respiration.

Nitric Oxide 2019 Apr 15. Epub 2019 Apr 15.

Universidad de Buenos Aires, Facultad de Medicina, Departamento de Bioquímica Humana, Paraguay 2155 5th Floor, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, Instituto de Investigaciones Biomédicas (INBIOMED), Buenos Aires, Argentina. Electronic address:

This article reviews the interactions between nitric oxide (NO) and mitochondrial respiration. Mitochondrial ATP synthesis is responsible for virtually all energy production in mammals, and every other process in living organisms ultimately depends on that energy production. Furthermore, both necrosis and apoptosis, that summarize the main forms of cell death, are intimately linked to mitochondrial integrity. Read More

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http://dx.doi.org/10.1016/j.niox.2019.04.005DOI Listing

Identification of circumferential regional heterogeneity of ascending thoracic aneurysmal aorta by biaxial mechanical testing.

J Mol Cell Cardiol 2019 Apr 15. Epub 2019 Apr 15.

Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS-ISMETT, Via Tricomi n.5, 90127 Palermo, Italy.

Ascending thoracic aortic aneurysm (ATAA) in patients with bicuspid aortic valve (BAV) can present an asymmetrical aortic dilatation compared with patients with tricuspid aortic valve (TAV). This pattern of aneurysm dilatation led us to hypothesize that biomechanical differences likely induced by regional heterogeneity of material properties can underlie the observed asymmetric enlargement discrepancies between BAV ATAA and TAV ATAA. This study aimed to characterize the mechanical properties and associated aortic tissue stiffness changes along the circumferential direction of aortic rings collected from surgically-repaired patients with ATAA. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2019.04.010DOI Listing

Unveiling toxicological aspects of venom from the Aesculapian False Coral Snake Erythrolamprus aesculapii.

Toxicon 2019 Apr 15. Epub 2019 Apr 15.

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto Nacional de Medicina Tropical (INMeT), Neuquén y Jujuy s/n, 3370, Puerto Iguazú, Argentina. Electronic address:

Most colubrid snake venoms have been poorly studied, despite the fact that they represent a great resource for biological, ecological, toxinological and pharmacological research. Herein, we explore the venom delivery system of the Aesculapian False Coral Snake Erythrolamprus aesculapii as well as some biochemical and toxicological properties of its venom. Its Duvernoy's venom gland is composed of serous secretory cells arranged in densely packed secretory tubules, and the most striking feature of its fang is their double-curved shape, exhibiting a beveled bladelike appearance near the tips. Read More

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http://dx.doi.org/10.1016/j.toxicon.2019.04.007DOI Listing

Exosomes on the border of species and kingdom intercommunication.

Transl Res 2019 Mar 29. Epub 2019 Mar 29.

Consorcio Regenero, Chilean Consortium for Regenerative Medicine, Santiago, Chile; Cells for Cells, Santiago, Chile; Laboratory of Nano-Regenerative Medicine, Faculty of Medicine, Universidad de los Andes, Santiago, Chile. Electronic address:

Over the last decades exosomes have become increasingly popular in the field of medicine. While until recently they were believed to be involved in the removal of obsolete particles from the cell, it is now known that exosomes are key players in cellular communication, carrying source-specific molecules such as proteins, growth factors, miRNA/mRNA, among others. The discovery that exosomes are not bound to intraspecies interactions, but are also capable of interkingdom communication, has once again revolutionized the field of exosomes research. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19315244193007
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http://dx.doi.org/10.1016/j.trsl.2019.03.008DOI Listing
March 2019
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Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction.

Crit Care Med 2019 Apr 15. Epub 2019 Apr 15.

Departamento de Ciencias Biologicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile.

Objectives: To determine whether circulating endothelial cells from septic shock patients and from nonseptic shock patients are transformed in activated fibroblast by changing the expression level of endothelial and fibrotic proteins, whether the level of the protein expression change is associated with the amount of administered resuscitation fluid, and whether this circulating endothelial cell protein expression change is a biomarker to predict sepsis survival.

Design: Prospective study.

Setting: Medical-surgical ICUs in a tertiary care hospital. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003778DOI Listing

Ferrocenes with simple chiral substituents: an in-depth theoretical and experimental VCD and ECD study.

Phys Chem Chem Phys 2019 Apr 18. Epub 2019 Apr 18.

Scuola Normale Superiore, Piazza dei Cavalieri 7, I-56126 Pisa, Italy.

Circular dichroism spectra in the IR range (VCD = vibrational circular dichroism) and in the UV range (ECD = electronic circular dichroism) have been recorded for both enantiomers of simple mono-substituted ferrocenes containing chiral pendants: 1-acetoxyethylferrocene, 1, 1-methoxyethylferrocene, 2, and 1-hydroxyethylferrocene, 3; the related disubstituted 1,1'-bis(1-hydroxyethyl)ferrocene, 4, was also considered. These two types of spectra, with the support of DFT calculations, concur to unequivocally confirm the absolute configuration for 1-4. In particular, our computational results point out the clear advantage of using an anharmonic oscillator model for the interpretation of VCD spectra of chiral ferrocenes. Read More

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http://dx.doi.org/10.1039/c9cp00437hDOI Listing
April 2019
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