4,720,239 results match your criteria Medical oncology Northwood London England[Journal]


[Modified Western Ontario and McMaster University Osteoarthritis Index Scale used in patients with knee osteoarthritis].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):537-541

Department of Traditional Chinese Medicine, the 2nd Affiliated Hospital of Harbin Medical University, Harbin 150081, China.

To modify Western Ontario and McMaster University Osteoarthritis Index (WOMAC) for more accurate evaluation of patients with knee osteoarthritis in China,and its reliability and validity were measured. The WOMAC was modified through reviewing relevant literatures and practical survey.Total of 120 patients were enrolled in this study. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.012DOI Listing
February 2019

[Different care models and symptom progression of Alzheimer's disease in China].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):532-536

Department of Psychiatry, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

To compare the differences of cognitive function, daily living ability and neuropsychiatric symptoms in patients with sporadic type of Alzheimer's disease (AD) under different care modes, and find the most favorable care mode for delaying the progress of disease. One hundred and twenty cases of AD patients were divided into three groups: Spouse Care Group, Adult Child Care Group and Nursing Home Group. Medical history collection and scale evaluation were carried out by trained specialists on 3 groups of patients and caregivers. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.011DOI Listing
February 2019

[Construction and analysis of gene co-expression networks in intracranial aneurysm].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):525-531

Department of Neurology, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China.

To analyze the expression microarray data in the public databases of intracranial aneurysms (IA) using bioinformatics, and to provide important information for the study of disease mechanisms. Gene co-expression network was constructed by weighted gene co-expression network analysis (WGCNA) based on the dataset (GSE75436) and pivot genes were identified. Using the online tool DAVID (Database for Annotation, Visualization, and Integrated Discovery) to perform GO function enrichment and KEGG path analysis on modules highly related to IA. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.010DOI Listing
February 2019

[Correlation between polymorphism of CYP19A1, GSTM1, GSTT1 and GSTP1 gene and endometriosis].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):515-519

Reproductive Medicine Center, the Affiliated Hospital of Inner Mongolia Medical University, Huhehot 010050, China.

To study the association between polymorphisms in CYP19A1 rs2899470, GSTM1, GSTT1, and GSTP1 rs1695 and the development of endometriosis. Between October 2015 and October 2017, 262 endometriosis patients and 275 control subjects were recruited from the Affiliated Hospital of Inner Mongolia Medical University. Genotyping was conducted using polymerase chain reaction-coupled with restriction fragment length polymorphism and multiplex allele specific polymerase chain reaction. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.008DOI Listing
February 2019

[Regulatory effect of exosomes secreted by vaginal wall fibroblasts on angiogenesis in patients with stress urinary incontinence].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):510-514

Department of Obstetrics & Gynecology, Shanxi Academy of Medical Sciences & Shanxi Da Yi Hospital, Shanxi Da Yi Hospital Affiliated to Shanxi Medical University, Taiyuan 030032, China.

Exosomes are considered to mediate intercellular communication by delivering biomolecules like mRNA, miRNA into recipient cells. The purpose of this study was to evaluate the effects of exosomes secreted by fibroblasts from women with stress urinary incontinence (SUI-EXO) on endothelial cells angiogenesis. Primary fibroblasts were acquired from periurethral vaginal wall tissues and exosomes were prepared by ultracentrifugation of fibroblasts cells conditioned medium. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.007DOI Listing
February 2019

[The effect of Cathepsin S in primary biliary cholangitis].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):505-509

Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Key Laboratory of Rheumatology and Cinical Immunology, Ministry of Education, Beijing 100730, China.

To explore the effect of cathepsin (Cat) S in primary biliary cholangitis (PBC). The serum of PBC patients and Hepatitis B virus (HBV) patients were collected in Peking Union Medical College Hospital from August 2016 to July 2017 and the liver tissue of PBC were collected from March 2010 to July 2013. Indirect enzyme-linked immunosorbent assay (ELISA) was used to detect the serum concentrations of total-and pro-Cat S respectively in 24 PBC patients, 24 Hepatitis B patients and 24 healthy controls. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.006DOI Listing
February 2019
1 Read

[Application of stretched exponential diffusion-weighted imaging model in quantitative diagnosis of nonalcoholic fatty liver disease: in a rabbit model].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):500-504

Department of Radiology, Northern Jiangsu People's Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, China.

To evaluate the feasibility of diffusion parameters obtained from mono-exponential and stretched exponential diffusion-weighted imaging models in staging of nonalcoholic fatty liver disease and compare the diagnosis ability of nonalcoholic steatohepatitis. Thirty-two 12 -week-old male New Zealand rabbits, about 2.5 kg of each, were randomly divided into five groups. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.005DOI Listing
February 2019

[Magnetic resonance imaging and diffusion weighted imaging features of focal peliosis hepatis].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):496-499

Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Medical Imaging, Department of Medical Imaging, Shanghai Medical College, Fudan University, Shanghai 200032, China.

To investigate the MRI and diffusion weighted imaging (DWI) features of focal peliosis hepatis. The clinical data and MRI of 19 cases with focal peliosis hepatis confirmed by pathology from January 2012 to March 2018 in Zhongshan Hospital of Fudan University were retrospectively analyzed. The number, location, size, shape, signal intensity of plain scan of lesions, enhancement pattern of lesions, vessels within lesions, and perfusion disorders of hepatic parenchyma were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.004DOI Listing
February 2019

[Computer-aided assessment of liver fibrosis progression in patients with chronic hepatitis B: an exploratory research].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):491-495

Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai Institute of Medical Imaging, Fudan University, Shanghai 200032, China.

To establish automatic liver fibrosis classification models by using traditional machine learning and deep learning methods and preliminaryly evaluate the efficiency. Gray scale ultrasound images and corresponding elastic images of 354 patients, 247 males and 107 females, mean age (54±12) years undergoing partial hepatectomy in Zhongshan Hospital of Fudan University from November 2014 to January 2016 were enrolled in this study. By using traditional machine learning and deep learning methods, an automatic classification model of liver fibrosis stages (S0 to S4) were established through feature extraction and classification of ultrasound image data sets and the accuracy in different classification categories of each model were calculated, by using liver biopsy as the reference standard. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.003DOI Listing
February 2019

[The imaging study and progress of liver fibrosis should be emphasized].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):481-483

Department of Medical Imaging, Tongji Hospital of Tongji University, Shanghai 200065, China.

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.001DOI Listing
February 2019

[Trans-jugular transcatheter closure of atrial septal defect solely under echocardiography guidance in infants].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):458-461

Department of Cardiovascular Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China.

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.015DOI Listing
February 2019

[Analysis of adverse events of clinical blood use except for the adverse reactions of blood transfusion].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):438-441

Department of Blood Transfusion, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

To reduce the occurrence of adverse events of clinical blood use by analyzing the clinical adverse events of blood use except for the adverse reactions of blood transfusion. A retrospective analysis was performed on 294 cases of adverse events of clinical blood use other than adverse blood transfusion reactions in Shijitan hospital from January 2014 to December 2017, and a statistical analysis was made on the types of adverse events of clinical blood use, blood transfusion related departments, and internal and surgical blood use. The incidence of adverse events of clinical blood use was 10. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.011DOI Listing
February 2019

[Diagnostic value of multiplex ligation dependent probe amplification combined with Sanger sequencing in 21-hydroxylase deficiency].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):432-437

Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Key Laboratory of Endocrinology, National Health Commission, Beijing 100730, China.

To study the procedure of gene mutation detection in 21-hydroxylase deficiency (21-OHD) patients. The detail clinical and biochemical data of 51 patients with 21-OHD [18 males and 33 females, with an average age of (16.4±9. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.010DOI Listing
February 2019

[Activation of GPER inhibts proliferation and autophagy in prostatic epithelial cells].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):419-422

Department of Urology, the First Affiliated Hospital of Guangzhou Medical College, Guangdong Key Laboratory of Urology, Guangzhou 510230, China.

To investigate the effect of G protein-coupled estrogen receptor (GPER) on proliferation and autophagy in prostatic epithelial cells. Cell Counting Kit-8 (CCK8) assay was used to observe the growth of BPH-1 and RWPE-1 cells after treating with or not with estradiol or GPER selective agonist G1. Autophagy was quantified with Western blot and Cyto-ID autophagy detection kit after treating with estradiol, G1 or both G1 and G15 in the same cells. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.007DOI Listing
February 2019

[Bronchial asthma and obstructive sleep apnea].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):414-415

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou 510120, China.

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.005DOI Listing
February 2019
1 Read

[Sleep and sleep related breathing disorders in chronic obstructive pulmonary disease].

Authors:
W Wang

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):411-413

Department of Respiratory and Critical Care Medicine, the First Hospital of China Medical University, Shenyang 110001, China.

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.004DOI Listing
February 2019

[Sleep and sleep breathing problems in lung cancer patients].

Authors:
X L Zhang B Y Chen

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):407-410

Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China.

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.003DOI Listing
February 2019

[Recognize sleep disorder in patients with common respiratory diseases].

Authors:
F Han B Y Chen

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):401-403

Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China.

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.001DOI Listing
February 2019

The self-perceptions of aging were an important factor associated with the quality of life in Chinese elderly with hypertension.

Psychogeriatrics 2019 Feb 20. Epub 2019 Feb 20.

Division of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: In China, quality of life (QOL) of the elderly with hypertension was lower than that of normal elderly and lower self-perceptions of aging (SPA) in the elderly with chronic diseases have been shown. Previous studies showed that SPA played a key role in QOL of the elderly. We hypothesised that SPA were associated with QOL in Chinese elderly with hypertension, with more negative SPA predicting lower QOL. Read More

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http://dx.doi.org/10.1111/psyg.12400DOI Listing
February 2019

Quantitative CT-derived vessel metrics in idiopathic pulmonary fibrosis: A structure-function study.

Respirology 2019 Feb 20. Epub 2019 Feb 20.

Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria.

Background And Objective: This study aimed to investigate whether quantitative lung vessel morphology determined by a new fully automated algorithm is associated with functional indices in idiopathic pulmonary fibrosis (IPF).

Methods: A total of 152 IPF patients had vessel volume, density, tortuosity and heterogeneity quantified from computed tomography (CT) images by a fully automated algorithm. Separate quantitation of vessel metrics in pulmonary arteries and veins was performed in 106 patients. Read More

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http://dx.doi.org/10.1111/resp.13485DOI Listing
February 2019

Abdominal CT evaluation of the liver and spleen for staging mast cell tumors in dogs yields nonspecific results.

Vet Radiol Ultrasound 2019 Feb 20. Epub 2019 Feb 20.

Department of Clinical Sciences and Services, The Royal Veterinary College, North Mymms, Hatfield, AL9 7TA, UK.

Canine mast cell tumor staging is commonly performed using abdominal ultrasonography and fine-needle aspiration cytology of masses, lymph nodes, and hepatic and splenic parenchyma. Computed tomography is used for abdominal, thoracic, or whole body imaging in staging mast cell tumors in the authors' institution enabling evaluation of multiple body areas in one examination. The aim of this study was to compare the CT examinations acquired for staging of mast cell disease to their subsequent liver and spleen cytology findings. Read More

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http://dx.doi.org/10.1111/vru.12717DOI Listing
February 2019

The prevalence and diagnostic classification of mixed features in patients with major depressive episodes: A multicenter study based on the DSM-5.

Int J Methods Psychiatr Res 2019 Feb 20:e1773. Epub 2019 Feb 20.

Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Objectives: The purpose of this study was to evaluate the prevalence of mixed features using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and to examine how patients with mixed states would be classified using the DSM-5.

Methods: In total, 12 hospitals participated in this study, and data on the demographic characteristics and clinical diagnoses of patients treated between October 2013 and September 2016 were obtained. We reviewed the data for opposite-polarity symptoms according to the DSM-5 criteria and the research-based diagnostic criteria. Read More

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http://dx.doi.org/10.1002/mpr.1773DOI Listing
February 2019

Tolerating uncertainty about conceptual models of uncertainty in health care.

J Eval Clin Pract 2019 Feb 20. Epub 2019 Feb 20.

Program for Evidence-based Medicine & Comparative Effectiveness Research, Department of Supportive Medicine, Department of Hematology, City of Hope National Medical Center, Duarte, California, USA.

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http://dx.doi.org/10.1111/jep.13110DOI Listing
February 2019

Legal and ethical implications of defining an optimum means of achieving unconsciousness in assisted dying.

Anaesthesia 2019 Feb 20. Epub 2019 Feb 20.

Nuffield Department of Anaesthetics, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

A decision by a society to sanction assisted dying in any form should logically go hand-in-hand with defining the acceptable method(s). Assisted dying is legal in several countries and we have reviewed the methods commonly used, contrasting these with an analysis of capital punishment in the USA. We expected that, since a common humane aim is to achieve unconsciousness at the point of death, which then occurs rapidly without pain or distress, there might be a single technique being used. Read More

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http://dx.doi.org/10.1111/anae.14532DOI Listing
February 2019

Clonal expansion of hepatic progenitor cells and differentiation into hepatocyte-like cells.

Dev Growth Differ 2019 Feb 20. Epub 2019 Feb 20.

Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Hepatic progenitor cells (HPCs) in adult liver are promising for treatment of liver diseases. A biliary-derived HPC population in adult mice has been characterized by co-expression of stem cell marker Sry (sex determining region Y)-box 9 (SOX9) and biliary marker cytokeratin 7 (CK7). However, isolation of these HPCs in adult healthy liver without any selection procedures remains a big challenge in this field. Read More

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http://dx.doi.org/10.1111/dgd.12596DOI Listing
February 2019

Occult Urinary Incontinence Treatment: Systematic Review and Meta-analysis-Brazilian Guidelines.

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):116-123. Epub 2019 Feb 20.

Faculty of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil.

Objective:  To evaluate if performing anti-incontinence procedures during surgical anterior and/or apical prolapse correction in women with asymptomatic urinary incontinence (UI) may prevent stress urinary incontinence (SUI) postoperatively.

Methods:  We have performed a systematic review of articles published in the PubMed, Cochrane Library, and Lilacs databases until March 31, 2016. Two reviewers performed the data collection and analysis, independently. Read More

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http://dx.doi.org/10.1055/s-0038-1676842DOI Listing
February 2019

Pethidine in Low Doses versus Dipyrone for Pain Relief in Labor: A Randomized Controlled Trial.

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):84-89. Epub 2019 Feb 20.

Graduate Program in Medical Sciences, Universidade de Fortaleza, Fortaleza, CE, Brazil.

Objective:  To compare low doses of pethidine with dipyrone in labor analgesia.

Methods:  In a randomized prospective study conducted by Universidade de Fortaleza, in the state of Ceará, Brazil, between May and December 2016, 200 full-term parturients, with very painful uterine contractions and exhibiting uterine cervix dilatation ≥ 5 cm, were selected to receive a single intravenous dose of either 0.25 mg/kg of pethidine ( = 100) or of 25 mg/kg of dipyrone ( = 100). Read More

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http://dx.doi.org/10.1055/s-0038-1676509DOI Listing
February 2019

Electronic Health Record Adoption and Nurse Reports of Usability and Quality of Care: The Role of Work Environment.

Appl Clin Inform 2019 Jan 20;10(1):129-139. Epub 2019 Feb 20.

Center for Health Outcomes and Policy Research, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania, United States.

Background:  Despite evidence suggesting higher quality and safer care in hospitals with comprehensive electronic health record (EHR) systems, factors related to advanced system usability remain largely unknown, particularly among nurses. Little empirical research has examined sociotechnical factors, such as the work environment, that may shape the relationship between advanced EHR adoption and quality of care.

Objective:  The objective of this study was to examine the independent and joint effects of comprehensive EHR adoption and the hospital work environment on nurse reports of EHR usability and nurse-reported quality of care and safety. Read More

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http://dx.doi.org/10.1055/s-0039-1678551DOI Listing
January 2019

[Health Expertise of Seasonal Influenza Vaccination among Midwife Trainees in North Rhine-Westphalia: Results of a Cross-Sectional Study].

Gesundheitswesen 2019 Feb 20. Epub 2019 Feb 20.

Institut für Hausarztmedizin, Medizinische Fakultät der Universität Bonn, Bonn.

Objective: For the first time, the level of knowledge and attitude towards vaccinations in general as well as seasonal influenza vaccination of midwife trainees in Germany was assessed.

Methods: The cross-sectional study was conducted between May and July 2017. The written standardized questionnaire was completed by all midwife-trainees in North Rhine-Westphalia. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0839-4810
Publisher Site
http://dx.doi.org/10.1055/a-0839-4810DOI Listing
February 2019
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A Nationwide Analysis of Preoperative Planning on Operative Times and Postoperative Complications in Total Knee Arthroplasty.

J Knee Surg 2019 Feb 20. Epub 2019 Feb 20.

Department of Orthopedic Surgery, Lenox Hill Hospital, Northwell Health, New York, New York.

Compared with nonelective total knee arthroplasties (TKAs), elective procedures have more time for preoperative planning, which allows for potentially improved patient optimization, risk factor modification, and patient education. The purpose of this study was to (1) determine nationwide trends in operative times and (2) evaluate associations between surgery type, elective or nonelective, with respect to (a) operative times, (b) length of stay (LOS), (c) discharge dispositions, (d) 30-day postoperative complications, (e) reoperations, and (f) readmissions. The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database was queried for all primary TKAs performed between 2011 and 2016. Read More

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http://dx.doi.org/10.1055/s-0039-1677790DOI Listing
February 2019

["Crystal" and Pregnancy - The Preliminary Results of a Retrospective Study on the Course of Pregnancy and Delivery of Women Consuming Methamphetamine].

Z Geburtshilfe Neonatol 2019 Feb 20. Epub 2019 Feb 20.

Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Carl Gustav Carus Dresden, Dresden.

Introduction: It can be observed that there is an increase in the methamphetamine (MA) consumption in Saxony (Federal Republic of Germany). There is so far no data available in German speaking countries about the risk of MA consumption in pregnancy or delivery.

Methods: The data from all pregnant women who were examined or delivered at the Clinic for Obstetrics and Gynaecology between 2010-2015 were retrospectively searched for MA consumption. Read More

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http://dx.doi.org/10.1055/a-0831-3642DOI Listing
February 2019

Free Vascularized Anterolateral Thigh Fascia Lata Flap for Reconstruction in Electrical Burns of the Severely Damaged Finger.

J Burn Care Res 2019 Feb;40(2):242-245

Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, P. R. China.

This study aimed to introduce a novel technique for reconstructing electricity-damaged fingers using a method combining the free vascularized anterolateral thigh fascia lata flap with skin grafting. From February 2015 to March 2017, 11 patients were enrolled in this retrospective case series. All patients suffered from electrical injury of the fingers and had severe soft tissue defects, with the exposure of tendon, vessels, or nerves. Read More

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http://dx.doi.org/10.1093/jbcr/irz010DOI Listing
February 2019

Sexual orientation identity in relation to unhealthy body mass index: individual participant data meta-analysis of 93 429 individuals from 12 UK health surveys.

J Public Health (Oxf) 2019 Feb 21. Epub 2019 Feb 21.

Public Health England, London, UK.

Background: Lesbian, gay and bisexual adults are more likely than heterosexual adults to experience worse health outcomes. Despite increasing public health interest in the importance of maintaining a healthy body weight, no study has considered sexual orientation identity (SOI) and unhealthy BMI categories among adults in the UK population.

Methods: Individual participant data meta-analysis using pooled data from population health surveys reporting on 93 429 adults with data on SOI, BMI and study covariates. Read More

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http://dx.doi.org/10.1093/pubmed/fdy224DOI Listing
February 2019

Effects of Trabeculectomy on Waveform Changes of Laser Speckle Flowgraphy in Open Angle Glaucoma.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):677-684

Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Purpose: To investigate the effect of trabeculectomy on the waveform changes of laser speckle flowgraphy (LSFG) in the optic nerve head (ONH) in patients with glaucoma.

Methods: Forty-eight eyes of 48 patients with open angle glaucoma were included in this prospective study. LSFG was performed before and 1, 3, and 6 months after trabeculectomy. Read More

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http://dx.doi.org/10.1167/iovs.18-25694DOI Listing
February 2019

Circular RNA biogenesis is decreased in postmortem cortical gray matter in schizophrenia and may alter the bioavailability of associated miRNA.

Neuropsychopharmacology 2019 Feb 20. Epub 2019 Feb 20.

School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, 2308, Australia.

Circular RNAs (circRNAs) are a covalently closed subclass of lncRNA molecules formed by back splicing of linear precursor RNA. These molecules are relatively stable and particularly abundant in the mammalian brain and therefore may participate in neural development and function. With the emergence of circRNAs activity in gene regulation, these molecules have been implicated in several biological processes, including synaptic plasticity, and we therefore suspect they may have a role in neurobehavioral disorders. Read More

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http://dx.doi.org/10.1038/s41386-019-0348-1DOI Listing
February 2019

Effect of dispersion in nerve on compound action potential and impedance change: a modelling study.

Physiol Meas 2019 Feb 20. Epub 2019 Feb 20.

Department of Medical Physics and Bioengineering, University College London, London, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Objective: Electrical impedance tomography (EIT) is capable of imaging fast compound electrical activity (Compound Action Potentials, or CAPs) inside peripheral nerves. The ability of EIT to detect impedance changes (dZ) which arise from the opening of ion channels during the CAP is limited by the dispersion with distance from the site of onset, as fibres have differing conduction velocities. The effect is largest for autonomic nerves mainly formed of slower conducting unmyelinated fibres where signals cannot be recorded more than a few cm away from the stimulation. Read More

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http://dx.doi.org/10.1088/1361-6579/ab08ceDOI Listing
February 2019

Bi-frequency symmetry difference electrical impedance tomography - a novel technique for perturbation detection in static scenes.

Physiol Meas 2019 Feb 20. Epub 2019 Feb 20.

Electrical and Electronic Engineering, National University of Ireland - Galway, Galway, Galway, IRELAND.

Objective: A novel method for the imaging of static scenes using Electrical Impedance Tomography (EIT) is reported with implementation and validation using numerical and phantom models. The technique is applicable to regions featuring symmetry in the normal case, asymmetry in the presence of a perturbation, and where there is a known, frequency-dependent change in the electrical conductivity of the materials in the region.

Methods: The stroke diagnostic problem is used as a motivating sample application. Read More

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http://dx.doi.org/10.1088/1361-6579/ab08baDOI Listing
February 2019

The ubiquitin ligase KBTBD8 regulates PKM1 levels via Erk1/2 and Aurora A to ensure oocyte quality.

Aging (Albany NY) 2019 Feb 20. Epub 2019 Feb 20.

State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, Jiangsu, P.R. China.

Tight control of energy metabolism is essential for normal cell function and organism survival. PKM (pyruvate kinase, muscle) isoforms 1 and 2 originate from alternative splicing of PKM pre-mRNA. They are key enzymes in oxidative phosphorylation and aerobic glycolysis, respectively, and are essential for ATP generation. Read More

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http://dx.doi.org/10.18632/aging.101802DOI Listing
February 2019

Assessing image artifacts from radiotherapy electromagnetic transponders with metal-artifact reduction imaging.

Magn Reson Imaging 2019 Feb 17. Epub 2019 Feb 17.

Department of Physics & Astronomy, University of Manitoba, Canada; Medical Physics, CancerCare Manitoba, Canada.

Image artifacts due to 14 gauge radiotherapy electromagnetic (EM) transponders were assessed on conventional spin echo images, and corrected using metal artifact reduction techniques: high bandwidth, view angle tilting (VAT), and slice encoding for metal artifact correction (SEMAC). Large areas of signal loss and/or pile-up were produced in an area extending up to 15.3 mm in radius for 14G transponders in standard imaging. Read More

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http://dx.doi.org/10.1016/j.mri.2019.02.005DOI Listing
February 2019

Continuous intracerebroventricular injection of Porphyromonas gingivalis lipopolysaccharide induces systemic organ dysfunction in a mouse model of Alzheimer's disease.

Exp Gerontol 2019 Feb 17. Epub 2019 Feb 17.

Department of Pharmacology and Molecular Therapeutics, Graduate School of Medical Sciences, Kumamoto University, Japan.

Systemic organ dysfunction is one of the important issues for the patients with Alzheimer's disease (AD) and their caregivers. Recent evidences suggest that periodontitis is a possible risk factor for progression of AD and lipopolysaccharide derived from Porphyromonas gingivalis (Pg-LPS) which is a major periodontopathic bacteria induces cognitive impairment in mice. However, the precise relationships between the brain exposure of Pg-LPS and systemic organ dysfunction in AD patients are still undetermined. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.007DOI Listing
February 2019

Unexpected term NICU admissions: a marker of obstetrical care quality?

Am J Obstet Gynecol 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA; Department of Pediatrics, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Harvard University, Boston, MA.

Background: Unexpected admissions of term neonates to the neonatal intensive care unit (NICU) and unexpected postnatal complications have been proposed as neonatal-focused quality metrics for intrapartum care. Previous studies have noted significant variation in overall hospital NICU admission rates; however, little is known about the influence of obstetric practices on these rates or whether variation among unanticipated admissions in low risk, term neonates can be attributed to systemic hospital practices.

Objective: To examine the relative effects of patient characteristics and intrapartum events on unexpected NICU admissions, and to quantify the between-hospital variation in NICU admission rates among this group of neonates. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.001DOI Listing
February 2019

Lutein prevents corticosterone-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities.

Pharmacol Biochem Behav 2019 Feb 17. Epub 2019 Feb 17.

Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903 Blumenau, Santa Catarina, Brazil.

Depression is a neuropsychiatry medical condition with high prevalence, in which the hypothalamic-pituitary-adrenal axis dysfunction has been postulated as the main cause. The glucocorticoids can be harmful to the brain, particularly by induction of oxidative stress and glutamatergic damage, therefore antioxidants or neuroprotective agents could have beneficial effects. Lutein (LUT) is a dietary xanthophyll able to arrive in the brain that has been used for therapy of macular degeneration. Read More

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http://dx.doi.org/10.1016/j.pbb.2019.02.004DOI Listing
February 2019

Cholinergic drugs ameliorate endothelial dysfunction by decreasing O-GlcNAcylation via M3 AChR-AMPK-ER stress signaling.

Life Sci 2019 Feb 17. Epub 2019 Feb 17.

Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, People's Republic of China. Electronic address:

Aims: Obesity is associated with increased cardiovascular morbidity and mortality. It is accompanied by augmented O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins via increasing hexosamine biosynthetic pathway (HBP) flux. However, the changes and regulation of the O-GlcNAc levels induced by obesity are unclear. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.036DOI Listing
February 2019

Reconstruction of effective connectivity in the case of asymmetric phase distributions.

J Neurosci Methods 2019 Feb 17. Epub 2019 Feb 17.

University of Cologne, Institute of Zoology, Heisenberg Research Group of Computational Neuroscience - Modeling Neural Network Function, Zülpicher Str. 47b, 50674 Cologne, Germany; Research Centre Jülich, Institute of Neuroscience and Medicine (INM-3), Cognitive Neuroscience, 52425 Jülich, Germany. Electronic address:

Background: The interaction of different brain regions is supported by transient synchronization between neural oscillations at different frequencies. Different measures based on synchronization theory are used to assess the strength of the interactions from experimental data. One method of estimating the effective connectivity between brain regions, within the framework of the theory of weakly coupled phase oscillators, was implemented in Dynamic Causal Modelling (DCM) for phase coupling (Penny et al. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2019.02.009DOI Listing
February 2019

Using A Developmental Ecology Framework to Align Fear Neurobiology Across Species.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychology, Columbia University, New York, NY 10027, USA; email: , , ,

Children's development is largely dependent on caregiving; when caregiving is disrupted, children are at increased risk for numerous poor outcomes, in particular psychopathology. Therefore, determining how caregivers regulate children's affective neurobiology is essential for understanding psychopathology etiology and prevention. Much of the research on affective functioning uses fear learning to map maturation trajectories, with both rodent and human studies contributing knowledge. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095727DOI Listing
February 2019

Abnormal Sleep Spindles, Memory Consolidation, and Schizophrenia.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215; email:

There is overwhelming evidence that sleep is crucial for memory consolidation. Patients with schizophrenia and their unaffected relatives have a specific deficit in sleep spindles, a defining oscillation of non-rapid eye movement (NREM) Stage 2 sleep that, in coordination with other NREM oscillations, mediate memory consolidation. In schizophrenia, the spindle deficit correlates with impaired sleep-dependent memory consolidation, positive symptoms, and abnormal thalamocortical connectivity. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095754DOI Listing
February 2019

Estrogen, Stress, and Depression: Cognitive and Biological Interactions.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Geriatric Research, Education, and Clinical Center, Tennessee Valley Veterans Affairs Medical Center, Nashville, Tennessee 37212, USA.

This article reviews the interactions of estrogen changes and psychosocial stress in contributing to vulnerability to major depressive disorder (MDD) in women. Estrogen modulates brain networks and processes related to changes in stress response, cognition, and emotional dysregulation that are core characteristics of MDD. Synergistic effects of estrogen on cognitive and emotional function, particularly during psychosocial stress, may underlie the association of ovarian hormone fluctuation and depression in women. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095557DOI Listing
February 2019

Mammalian Respiratory Complex I Through the Lens of Cryo-EM.

Annu Rev Biophys 2019 Feb 20. Epub 2019 Feb 20.

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, United Kingdom; email: , , ,

Single-particle electron cryomicroscopy (cryo-EM) has led to a revolution in structural work on mammalian respiratory complex I. Complex I (mitochondrial NADH:ubiquinone oxidoreductase), a membrane-bound redox-driven proton pump, is one of the largest and most complicated enzymes in the mammalian cell. Rapid progress, following the first 5-Å resolution data on bovine complex I in 2014, has led to a model for mouse complex I at 3. Read More

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http://dx.doi.org/10.1146/annurev-biophys-052118-115704DOI Listing
February 2019

Risk Factors for Dental Restoration Survival: A Practice-Based Study.

J Dent Res 2019 Feb 20:22034519827566. Epub 2019 Feb 20.

1 Department of Dentistry, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands.

To improve patient dental care, it is necessary to identify possible risk factors for the failing of restorations. This practice-based cohort study investigated the performance and influence of possible risk factors at the level of the practice, patient, tooth, and restoration on survival of direct class II restorations. Electronic patient files from 11 Dutch general practices were collected, and 31,472 restorations placed between January 2015 and October 2017 were analyzed. Read More

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http://dx.doi.org/10.1177/0022034519827566DOI Listing
February 2019

Kratom exposures reported to United States poison control centers: 2011-2017.

Clin Toxicol (Phila) 2019 Feb 20:1-8. Epub 2019 Feb 20.

a Center for Injury Research and Policy , The Research Institute at Nationwide Children's Hospital , Columbus , OH , USA.

Context: Kratom, or Mitragyna speciosa, is a plant indigenous to Southeast Asia that has gained national attention in the United States for its increased use in the self-management of opioid withdrawal and pain, as well as for concerns about its safety.

Methods: This study analyzes exposures to kratom reported to poison control centers (PCCs) in the United States during 2011-2017 from the National Poison Data System (NPDS).

Discussion: From 2011 through 2017, 1807 kratom exposures were reported to United States PCCs. Read More

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http://dx.doi.org/10.1080/15563650.2019.1569236DOI Listing
February 2019
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