4,785,381 results match your criteria Medical oncology Northwood London England[Journal]


PTEN-deficient prostate cancer is associated with an immunosuppressive tumor microenvironment mediated by increased expression of IDO1 and infiltrating FoxP3+ T regulatory cells.

Prostate 2019 Apr 18. Epub 2019 Apr 18.

Cancer Biology and Genetics, Queen's Cancer Research Institute, Queen's University, Kingston, Canada.

Background: Accumulating evidence shows that tumor cell-specific genomic changes can influence the cross talk between cancer cells and the surrounding tumor microenvironment (TME). Loss of the PTEN tumor suppressor gene is observed in 20% to 30% of prostate cancers (PCa) when first detected and the rate increases with PCa progression and advanced disease. Recent findings implicate a role for PTEN in cellular type I interferon response and immunosuppression in PCa. Read More

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http://dx.doi.org/10.1002/pros.23808DOI Listing

Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma.

Cochrane Database Syst Rev 2019 Apr 19;4:CD011875. Epub 2019 Apr 19.

Ophthalmology, Singapore National Eye Centre, Singapore, Singapore.

Background: Glaucoma affects more than 70 million people worldwide, with about 10% being bilaterally blind, making it the leading cause of irreversible blindness globally. In patients with advanced glaucoma or those who have failed medical treatment without achieving adequate intraocular pressure (IOP) control, trabeculectomy (glaucoma filtration surgery where an ostium is created into the anterior chamber from underneath a partial thickness scleral flap to allow for aqueous flow out of the anterior chamber intointo the subconjunctival space forming a filtering bleb) and aqueous shunt surgery for more complex and refractory cases remain the mainstay therapies. Proliferation of fibrous tissue around an implanted aqueous shunt may block the diffusion of aqueous humour. Read More

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http://doi.wiley.com/10.1002/14651858.CD011875.pub2
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http://dx.doi.org/10.1002/14651858.CD011875.pub2DOI Listing
April 2019
1 Read

Resilience in the midst of chaos: Socioecological model applied to women with depressive symptoms and socioeconomic disadvantage.

J Community Psychol 2019 Apr 18. Epub 2019 Apr 18.

Department of Psychiatry, University of Rochester School of Medicine, Rochester, New York.

Socioeconomic disadvantage is extremely common among women with depressive symptoms presenting for women's health care. While social stressors related to socioeconomic disadvantage can contribute to depression, health care tends to focus on patients' symptoms in isolation of context. Health care providers may be more effective by addressing issues related to socioeconomic disadvantage. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcop.22188
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http://dx.doi.org/10.1002/jcop.22188DOI Listing
April 2019
1 Read

Hyperglycemia and T Cell infiltration are associated with stromal and epithelial prostatic hyperplasia in the nonobese diabetic mouse.

Prostate 2019 Apr 18. Epub 2019 Apr 18.

Department of Surgery, NorthShore University HealthSystem, Evanston, Illinois.

Background: Prostatic inflammation and various proinflammatory systemic comorbidities, such as diabetes and obesity are associated with human benign prostatic hyperplasia (BPH). There is a paucity of in vivo models reflecting specific aspects of BPH pathogenesis. Our aim was to investigate the nonobese diabetic (NOD) mouse as a potential model for subsequent intervention studies. Read More

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http://dx.doi.org/10.1002/pros.23809DOI Listing
April 2019
5 Reads

The Lowering of Bilirubin Levels in Full-Term Newborns by the Effect of Combined Massage Therapy and Phototherapy Practice.

Am J Perinatol 2019 Apr 18. Epub 2019 Apr 18.

Faculty of Medicine, Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.

Objective:  Various therapeutic treatments have been prescribed for decreasing the bilirubin level. Massage therapy is one of the neonate treatments for jaundice. The aim of this study is to investigate the effects of combined massage therapy and phototherapy on neonatal jaundice. Read More

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http://dx.doi.org/10.1055/s-0039-1685493DOI Listing

Dupilumab and Alopecia: Causative or Therapeutic?

Dermatology 2019 Apr 18:1-2. Epub 2019 Apr 18.

Division of Dermatology, University of Arizona Department of Medicine, Tucson, Arizona, USA,

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http://dx.doi.org/10.1159/000499080DOI Listing

Behavioral and Biochemical Features of the Course and Surgical Treatment of Experimental Obstructive Hydrocephalus in Young Rats.

Dev Neurosci 2019 Apr 18:1-10. Epub 2019 Apr 18.

Division of Pediatric Neurosurgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Introduction: Hydrocephalus is a multifactorial disease, affecting the dynamics of cerebrospinal fluid (CSF) and leading to severe neurological impairment in children; in spite of the recent advances in hydrocephalus research, it has many physiopathological aspects that still remain poorly understood, especially after treatment.

Objectives: To analyze the clinical, radiological, histopathological, and biochemical aspects of kaolin-induced hydrocephalus in an experimental model, both in the acute phase and after shunt treatment, by means of behavioral tests, magnetic resonance imaging (MRI) scans, histopathological studies, and level of inflammatory interleukins in the CSF.

Methods: Seven-day-old Wistar rats were used and subdivided into three subgroups: treated hydrocephalic (n = 24), untreated hydrocephalic (n = 17), and controls (n = 5). Read More

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http://dx.doi.org/10.1159/000497433DOI Listing

A Comparative Study of Google Search Trends for Melanoma, Breast Cancer and Prostate Cancer in Finland.

Dermatology 2019 Apr 18:1-2. Epub 2019 Apr 18.

Aava Kamppi Medical Centre, Helsinki, Finland.

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https://www.karger.com/Article/FullText/498987
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http://dx.doi.org/10.1159/000498987DOI Listing
April 2019
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Medical Misinformation: Vet the Message!

Authors:
Joseph A Hill

Cardiology 2019 Apr 18;142(2):63-65. Epub 2019 Apr 18.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA,

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https://www.karger.com/Article/FullText/497263
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http://dx.doi.org/10.1159/000497263DOI Listing
April 2019
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What Is a Better Procedural Methodology for Endomyocardial Biopsy.

Authors:
Teruhiko Imamura

Cardiology 2019 Apr 18;142(2):66. Epub 2019 Apr 18.

Division of Cardiology, University of Chicago Medical Center, Chicago, Illinois, USA,

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http://dx.doi.org/10.1159/000499340DOI Listing

Interaction of BRAF-induced ETS factors with mutant TERT promoter in papillary thyroid cancer.

Endocr Relat Cancer 2019 Apr 1. Epub 2019 Apr 1.

Y Park, Internal medicine, Seoul National University College of Medicine, Seoul, Korea (the Republic of).

Synergistic effects of BRAFV600E and TERT promoter mutations on the poor clinical outcomes in papillary thyroid cancer (PTC) have been demonstrated. The potential mechanism of this phenomenon has been proposed: MAPK pathway activation by the BRAFV600E mutation may upregulate E-twenty six (ETS) transcription factors, increasing TERT expression by binding to the ETS-binding site generated by the TERT promoter mutation; however, it has not yet been fully proven. This article provides transcriptomic insights into the interaction between BRAFV600E and TERT promoter mutations mediated by ETS factors in PTC. Read More

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http://dx.doi.org/10.1530/ERC-17-0562DOI Listing

High soluble CGA levels are associated with poor survival in bladder cancer.

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

H Reis, Institute of Pathology , University of Essen-Duisburg, Essen, Germany.

Recently, a neuroendocrine-like molecular subtype has been discovered in muscle-invasive urothelial bladder cancer (BC). Chromogranin A (CGA) is a widely used tissue and serum marker in neuroendocrine tumors. Our aim was to evaluate serum CGA (sCGA) concentrations and their associations with clinical and follow-up data in BC and renal cell carcinoma (RCC). Read More

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http://dx.doi.org/10.1530/EC-19-0068DOI Listing

MADD silencing enhances anti-tumor activity of TRAIL in anaplastic thyroid cancer.

Endocr Relat Cancer 2019 Jun;26(6):551-563

Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA.

ATC is an aggressive disease with limited therapeutic options due to drug resistance. TRAIL is an attractive anti-cancer therapy that can trigger apoptosis in a cancer cell-selective manner. However, TRAIL resistance is a major clinical obstacle for its use as a therapeutic drug. Read More

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https://erc.bioscientifica.com/view/journals/erc/26/6/ERC-18
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http://dx.doi.org/10.1530/ERC-18-0517DOI Listing
June 2019
1 Read
4.805 Impact Factor

Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation.

Stem Cell Res 2019 Apr 10;37:101434. Epub 2019 Apr 10.

Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA. Electronic address:

Patient-derived induced pluripotent stem cells (iPSCs) have become a promising resource for exploring genetics of complex diseases, discovering new drugs, and advancing regenerative medicine. Increasingly, laboratories are creating their own banks of iPSCs derived from diverse donors. However, there are not yet standardized guidelines for qualifying these cell lines, i. Read More

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http://dx.doi.org/10.1016/j.scr.2019.101434DOI Listing

Multiplatform metabolomics provides insight into the molecular basis of chronic kidney disease.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 3;1117:49-57. Epub 2019 Apr 3.

Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gdańsk, Poland. Electronic address:

Changes in metabolites composition can reflect currently present pathological processes in a living organism and constitute a basis for diagnosis and treatment improvements. Thus, the multiplatform metabolomics approach was applied for the investigation of molecular mechanisms of chronic kidney disease (CKD) progression. The high-performance liquid chromatography coupled with time-of-flight mass spectrometry (HPLC-TOF-MS) and gas chromatography coupled with triple quadrupole mass spectrometry (GC-QqQ/MS) serum metabolic fingerprinting followed by uni- and multivariate statistical analysis was carried out to determine metabolic pattern differentiating CKD patients and healthy controls. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.04.003DOI Listing

Machine learning and big data in psychiatry: toward clinical applications.

Curr Opin Neurobiol 2019 Apr 15;55:152-159. Epub 2019 Apr 15.

Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, England, United Kingdom; Division of Psychiatry, University College London, London, England, United Kingdom; Camden and Islington NHS Foundation Trust, London, England, United Kingdom. Electronic address:

Psychiatry is a medical field concerned with the treatment of mental illness. Psychiatric disorders broadly relate to higher functions of the brain, and as such are richly intertwined with social, cultural, and experiential factors. This makes them exquisitely complex phenomena that depend on and interact with a large number of variables. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09594388183008
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http://dx.doi.org/10.1016/j.conb.2019.02.006DOI Listing
April 2019
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Long-term safety and efficacy following conversion to eslicarbazepine acetate monotherapy in adults with focal seizures.

Epilepsy Res 2019 Mar 29;153:59-65. Epub 2019 Mar 29.

Sunovion Pharmaceuticals Inc., 84 Waterford Drive, Marlborough, MA, 01752, USA.

Objective: To assess the long-term safety and efficacy of eslicarbazepine acetate (ESL) monotherapy in adults with focal seizures (FS).

Methods: Study 050 was a long-term, multicenter, open-label (OL) safety extension of two conversion-to-ESL monotherapy studies in adults with refractory FS. After participating in Study 045 or 046, patients started on ESL 1600 mg once daily (QD) (or 1200 mg if they previously had a dose reduction), and could adjust the dose 400 mg/week to a dose between 800-2400 mg QD. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.018DOI Listing

Contamination of a hospital plumbing system by persister cells of a copper-tolerant high-risk clone of Pseudomonas aeruginosa.

Water Res 2019 Apr 10;157:579-586. Epub 2019 Apr 10.

Laboratoire d'Hygiène Hospitalière, Centre Hospitalier Régional Universitaire, Besançon, France; UMR CNRS 6249, Chrono-environnement, Université de Bourgogne Franche-Comté, Besançon, France; Centre de Ressources Biologiques - Filière Microbiologique de Besançon, Centre Hospitalier Régional Universitaire, Besançon, France. Electronic address:

Background: Pseudomonas aeruginosa (PA) is an important opportunistic pathogen that thrives best in the distal elements of plumbing and waste-water systems. Although nosocomial outbreaks of PA have been associated with water sources, the role of the plumbing system of healthcare premises as a reservoir for this pathogen is still unclear.

Materials And Methods: We collected water samples from 12 technical areas, distant from any medical activity, in a teaching hospital in France once a week for 11 weeks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00431354193031
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http://dx.doi.org/10.1016/j.watres.2019.04.011DOI Listing
April 2019
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Unverricht-Lundborg disease: Clinical course and seizure management based on the experience of polish centers.

Authors:
Anetta Lasek-Bal

Seizure 2019 Apr 10;69:87-91. Epub 2019 Apr 10.

Department of Neurology, School of Health Sciences, Medical University of Silesia in Katowice, 40-635, Katowice, Poland. Electronic address:

The purpose of this paper was to present our experience following the longterm treatment of 11 patients with Unverricht-Lundborg disease (ULD) confirmed by molecular testing.

Methods: We analyzed the clinical course, cognitive state, neuroimaging and neurophysiology results.

Results: The data were collected from 9 unrelated families (F/M: 4/7) aged 25-49. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.04.008DOI Listing

Intraoperative ultrasonography (ioUS) characteristics of focal cortical dysplasia (FCD) type II b.

Seizure 2019 Mar 12;69:80-86. Epub 2019 Mar 12.

Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy; Department of Neurological Surgery, Johns Hopkins Medical School, Baltimore, MD, USA.

Purpose: Focal cortical dysplasia (FCD) is one of the major causes of drug-resistant epilepsy. Surgery has proved to be the treatment of choice, however up to a third of patients experience only partial resection. Ill-defined borders and lesions embedded in eloquent areas are two of the main drawbacks of FCD surgery. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.02.020DOI Listing

Parental views on state cannabis laws and marijuana use for their medically vulnerable children.

Drug Alcohol Depend 2019 Feb 14;199:59-67. Epub 2019 Feb 14.

Division of Adolescent and Young Adult Medicine, Boston Children's Hospital, Boston, MA, United States; Department of Pediatrics, Harvard Medical School, Boston, MA, United States.

Background: Given a rapidly changing policy landscape, we sought to characterize the effects of state marijuana laws on parents' views of marijuana use by their teenage children.

Methods: Data are from 595 respondents to a nationally administered, web-based survey of parents of adolescents (ages 13-18 years) with any of three chronic conditions (type 1 diabetes, rheumatic disease, attention-deficit/hyperactivity disorder). Multivariate ordinal logistic regression was used to model the effects of parents' reports of state cannabis laws on their views toward marijuana use by their child. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.12.027DOI Listing
February 2019

Vieloplains A-G, seven new guaiane-type sesquiterpenoid dimers from Xylopia vielana.

Bioorg Chem 2019 Apr 10;88:102891. Epub 2019 Apr 10.

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China; Institute of Interdisciplinary Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China; School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China. Electronic address:

Seven new guaiane-type sesquiterpene dimers vieloplains A-G, connecting patterns through three different direct CC bonds compounds 1-5 (C-3 to C-3', C-4 to C-1'), compound 6 (C-2 to C-3', C-4 to C-2') and compound 7 (C-2 to C-1', C-4 to C-2') were isolated from the roots of Xylopia vielana. Their absolute configurations were established by NOESY analysis, the Cu Kα X-ray crystallographic the experiment circular dichroism (ECD) and the calculated ECD. Among them, only compound 6 showed a considerable cytotoxicity against DU145 cells with IC values of 9. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.03.065DOI Listing

More targeted use of oseltamivir and in-hospital isolation facilities after implementation of a multifaceted strategy including a rapid molecular diagnostic panel for respiratory viruses in immunocompromised adult patients.

J Clin Virol 2019 Apr 7;116:11-17. Epub 2019 Apr 7.

Department of Infectious Diseases, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Background: Immunocompromised adults are more vulnerable to a complicated course of viral respiratory tract infections (RTI).

Objectives: Provide evidence on the effect of implementation of rapid molecular diagnostics for viruses on use of in-hospital isolation facilities, oseltamivir and antibiotic usage, and other clinical outcomes in immunocompromised patients.

Study Design: A before-after study during two consecutive respiratory viral seasons, including immunocompromised adult patients presenting at a tertiary care emergency department with clinical suspicion of RTI. Read More

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http://dx.doi.org/10.1016/j.jcv.2019.04.003DOI Listing

A method for the cell-cycle-specific analysis of radiation-induced chromosome aberrations and breaks.

Mutat Res 2019 Apr 6;815:10-19. Epub 2019 Apr 6.

Institute of Medical Radiation Biology, University of Duisburg-Essen Medical School, Essen, Germany. Electronic address:

The classical G-assay is widely used to assess cell-radiosensitivity and cancer phenotype: Cells are exposed to low doses of ionizing-radiation (IR) and collected for cytogenetic- analysis ˜1.5 h later. In this way, chromosome-damage is measured in cells irradiated in G-phase, without retrieving information regarding kinetics of chromosome-break-repair. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00275107193003
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http://dx.doi.org/10.1016/j.mrfmmm.2019.04.001DOI Listing
April 2019
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Serotonin transporter gene methylation predicts long-term cortisol concentrations in hair.

Psychoneuroendocrinology 2019 Mar 29;106:179-182. Epub 2019 Mar 29.

Chair of Biopsychology, Faculty of Psychology, Technische Universität Dresden, Germany.

Epigenetic signatures, such as DNA methylation (DNA), have been implicated in long-term dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis and related health risks. Based on a wealth of neuroendocrine studies on genetic polymorphisms in the serotonin transporter gene (SLC6A4), this locus constitutes a key candidate to explore associations of DNA patterns and HPA-axis functioning. The few studies addressing this link so far exclusively relied on spot measurements of HPA-axis activity, which may not adequately reflect cortisol output over prolonged periods of time. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064530193007
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http://dx.doi.org/10.1016/j.psyneuen.2019.03.033DOI Listing
March 2019
1 Read

Lysophospholipid profiles of apolipoprotein E-deficient mice reveal potential lipid biomarkers associated with atherosclerosis progression using validated UPLC-QTRAP-MS/MS-based lipidomics approach.

J Pharm Biomed Anal 2019 Apr 5;171:148-157. Epub 2019 Apr 5.

Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Lysophospholipids (Lyso-PLs) are lipid-derived signaling molecules which were demonstrated to have a strong correlation with the progression of atherosclerosis. In this study, we investigated the influence of high-fat diet on Lyso-PL profiles of atherosclerosis-prone apolipoprotein E-deficient (ApoE) mice and wild type C57BL/6 J mice to find out the potential biomarkers associated with atherosclerosis. Firstly, the quantitative profiling method for Lyso-PLs based on ultra-performance liquid chromatography-quadrupole linear ion trap mass spectrometry (UPLC-QTRAP-MS/MS) was established and validated. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.03.062DOI Listing

Impacts of rare earth elements on animal health and production: Highlights of cerium and lanthanum.

Sci Total Environ 2019 Mar 13;672:1021-1032. Epub 2019 Mar 13.

Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt. Electronic address:

Because the use of antibiotics as growth promoters was banned due to global health concerns, researchers are focusing on exploring alternative safe and effective feed additives. Rare earth elements (REEs) are located in group III of the periodic table, which includes cerium (Ce), lanthanum (La), and other elements. Recently, REEs have been involved in many medical, industrial, zootechnical, and agricultural applications. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.270DOI Listing

STIM1 structure-function and downstream signaling pathways.

Cell Calcium 2019 Apr 8;80:101-102. Epub 2019 Apr 8.

Institute of Biophysics, Johannes Kepler University Linz, Life Science Center, Gruberstrasse 40, 4020 Linz, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2019.01.004DOI Listing

The effect of testosterone therapy on personality traits of trans men: a controlled prospective study in Germany and Switzerland.

Psychiatry Res 2019 Apr 1;276:31-38. Epub 2019 Apr 1.

Department of Consultation-Liaison-Psychiatry and Psychosomatic Medicine, University Hospital Zurich, Rämistrasse 100, 8002 Zürich, Switzerland.

Gender dysphoria in transgender men is generally treated with exogenous testosterone administration aiming to suppress secondary female sex characteristics and achieve masculinization. However, the effect of testosterone on the personality of transgender men remains largely unknown. Therefore, we conducted a controlled study with 23 trans men (M = 27. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.03.053DOI Listing

Baicalein attenuates pancreatic inflammatory injury through regulating MAPK, STAT 3 and NF-κB activation.

Int Immunopharmacol 2019 Apr 15;72:204-210. Epub 2019 Apr 15.

Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address:

Acute pancreatitis (AP) is a common acute abdominal disease with local or systemic inflammatory response, caused by abnormal activation of digestive enzymes. Baicalein has been shown to exert anti-inflammatory effects and to attenuate the pathological changes of AP. The aim of the research was to investigate the effects of baicalein on caerulein induced pancreatitis, and to elucidate the putative underlying mechanism. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.018DOI Listing

Experimental and theoretical insights on the effect of solvent polarity on the photophysical properties of a benzanthrone dye.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 3;218:221-228. Epub 2019 Apr 3.

Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.

Benzanthrone derivatives show interesting solvent dependent photophysical properties. Understanding of their photophysical properties is essential for developing the fluorescence probes based on benzanthrone derivatives. The photophysical properties of 3-(N'-chlorophenyl)piperazino-7H-benzo[de]anthracen-7-one [ClPh-PBA] molecule are reported in different solvents and solvent mixtures. Read More

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http://dx.doi.org/10.1016/j.saa.2019.04.001DOI Listing

Effects of perfluorooctanoic acid on stem Leydig cell functions in the rat.

Environ Pollut 2019 Apr 9;250:206-215. Epub 2019 Apr 9.

Department of Pediatrics, Peking University First Hospital, No.1 Xi'an Men Street, West District, Beijing, 100034, China; Department of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China. Electronic address:

Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic (PFOS) are two perfluorinated chemical products widely existing in the environment. Evidence suggested that PFOA might relate to male reproductive dysfunction in rats and humans. PFOA exposure inhibited the function of Leydig cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491193015
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http://dx.doi.org/10.1016/j.envpol.2019.03.120DOI Listing
April 2019
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A new technique for sensory blockage of posterior branches of sacral nerves: Ultrasound guided sacral erector spinae plane block.

J Clin Anesth 2019 Apr 15;57:129-130. Epub 2019 Apr 15.

Maltepe University Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey.

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http://dx.doi.org/10.1016/j.jclinane.2019.04.014DOI Listing

Targeted fluoroscopic guided epidural blood patch using a Racz catheter for spontaneous intracranial hypotension.

J Clin Anesth 2019 Apr 15;57:122-123. Epub 2019 Apr 15.

Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Midorigaoka-higashi 2-1-1-1, Asahikawa, Hokkaido 078-8510, Japan.

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http://dx.doi.org/10.1016/j.jclinane.2019.04.022DOI Listing

Association of wheat chaff derived silica fiber and esophageal cancer in north China.

Ecotoxicol Environ Saf 2019 Apr 15;178:79-85. Epub 2019 Apr 15.

School of Public Health, The University of Hong Kong, 7 Sassoon Road, Hong Kong SAR, China. Electronic address:

Background: Despite decades of research and intervention programs, the epidemic of esophageal squamous cell carcinoma (ESCC) in the Taihang Mountain area of north China has not seen convincing explanation by any risk factor yet and the incidence has not seen a substantial decrease. Based on recently disclosed association of aridity and wheat consumption with esophageal cancer, we revisited the hypothesis of biogenic silica in esophageal cancer development.

Methods: From the archives of the Pathology Department of Heping Hospital, Changzhi Medical College, we selected three pairs of formalin-fixed samples, tumor tissues and distant normal tissues, of three patients operated for ESCC who had no history of workplace exposure to silica dust. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513193045
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http://dx.doi.org/10.1016/j.ecoenv.2019.04.031DOI Listing
April 2019
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Association between methylation of DNA damage response-related genes and DNA damage in hepatocytes of rats following subchronic exposure to vinyl chloride.

Chemosphere 2019 Apr 9;227:323-328. Epub 2019 Apr 9.

Department of Statistics, School of Public Health, Shanxi Medical University, Taiyuan, China.

In the present study, we investigated the association between methylation of DNA damage response-related genes such as cyclin-dependent kinase inhibitor (CDKN)2A, Ras association (RalGDS/AF-6) domain family member (RASSF)1A, O6-methylguanine DNA methyltransferase (MGMT), Kirsten rat sarcoma viral oncogene homolog (KRAS), and spleen-associated tyrosine kinase (SYK) and DNA damage in hepatocytes of rats following subchronic exposure to vinyl chloride (VC). Sixty-four healthy rats were randomly divided into three VC exposure groups (5, 25, and 125 mg/kg) and an untreated negative control group (n = 16 each). VC was administered by intraperitoneal injection every other day for a total of three times a week. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.058DOI Listing

Polycyclic aromatic hydrocarbons (PAHs) formation during the fast pyrolysis of hazardous health-care waste.

Chemosphere 2019 Apr 5;227:277-288. Epub 2019 Apr 5.

Farayand Sabz Pakan Co., Tehran, Iran. Electronic address:

Health-care waste management is a challenge for the health sector. Currently, pyrolysis technologies are being used to treat medical waste that can convert it to a hydrocarbon fuel. In the present study, hazardous health-care waste was pyrolyzed using a continuous tubular fast pyrolysis reactor. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.028DOI Listing

Interdisciplinary collaboration needed in obtaining high-quality medical information in child abuse investigations.

Child Abuse Negl 2019 Apr 15;92:167-178. Epub 2019 Apr 15.

Medical College of Wisconsin, 8701 W. Watertown Plank Rd., Wauwatosa, WI, 53226, USA.

Background: Despite reporting legislation, healthcare providers (HCPs) do not always report and collaborate in cases of suspected child abuse. Recognizing this leaves children at risk, the Wisconsin Child Abuse Network (WI CAN) sought to understand barriers to mandated reporting and collaboration with child abuse investigators.

Objective: The purpose of the study was to investigate barriers for professionals in providing and obtaining high-quality medical information in child abuse investigations. Read More

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http://dx.doi.org/10.1016/j.chiabu.2019.02.012DOI Listing

Immunohistochemical analysis of retraction pocket pars tensa of tympanic membrane in children.

Int J Pediatr Otorhinolaryngol 2019 Apr 11;122:111-116. Epub 2019 Apr 11.

Department of Pediatrics, University Hospital Brno and Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.

Aims: Immunohistochemical analysis of retraction pocket pars tensa of tympanic membrane in children. Identification of signs typical for cholesteatoma and support of retraction theory of cholesteatoma.

Study Design: a prospective study analysing 31 surgically removed retraction pockets. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876193017
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http://dx.doi.org/10.1016/j.ijporl.2019.04.008DOI Listing
April 2019
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EEG changes in patients on antipsychotic therapy: A systematic review.

Epilepsy Behav 2019 Apr 15;95:1-9. Epub 2019 Apr 15.

Department of Neuroscience, Monash Medical Centre, Clayton, Victoria, Australia; School of Clinical Sciences at Monash Health, Department of Medicine, Monash University, Melbourne, Victoria, Australia; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia. Electronic address:

Objectives: The objective of the study was to characterize the electroencephalogram (EEG) changes associated with different antipsychotic medications based on the evidence from the literature.

Methods: A systematic search of the databases Medline, PsycINFO, and PubMed was conducted. The Preferred Items Reporting for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed in the construction of this systematic review. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.02.005DOI Listing

Solitary contralateral adrenal metastasis of renal cell carcinoma 15 years following radical nephrectomy: A case report and review of literature.

Int J Surg Case Rep 2019 Apr 5;58:33-36. Epub 2019 Apr 5.

University of Sulaymaniyah, Faculty of Medical Sciences, School of Medicine, Department of Radiology, Iraq.

Introduction: Renal cell carcinoma (RCC) is known to metastasize to almost every organ. A well-recognized phenomenon in RCC is late metastatic recurrence after nephrectomy which is arbitrarily defined as more than 10 years. The incidence of solitary ipsilateral and contralateral adrenal metastasis is 3% and 0. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.049DOI Listing

Appendiceal mucocele-A rare case report.

Int J Surg Case Rep 2019 Apr 9;58:21-25. Epub 2019 Apr 9.

Deprtment of General Surgery, JSS Medical College and Hospital, Mysore, India. Electronic address:

Introduction: Appendiceal mucocele is a rare disease and has a clinical picture that resembles acute appendicitis. A correct diagnosis before surgery is very important for the selection of surgical technique(appendicectomy/colectomy)to avoid severe intraoperative and postoperative complications. The work has been reported in line with the SCARE criteria (Agha et al. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.04.008DOI Listing

Successful outcome after Pancreaticodoudenectomy in an elderly cirrhotic patient: A case report.

Int J Surg Case Rep 2019 Apr 10;58:18-20. Epub 2019 Apr 10.

Department of HPB Surgery and Liver Transplantation, Shifa International Hospital, Islamabad, Pakistan; Department of Surgery, Shifa Tameer-e-Millat University, Islamabad, Pakistan. Electronic address:

Introduction: Cirrhosis is a risk factor for poor outcomes in non-hepatic oncological resections. There are only a handful of cases demonstrating outcomes of pancreaticoduodenectomy (PD) in patients with pancreatic cancer and underlying cirrhosis. Moreover, pushing the limits of PD to elderly cirrhotic patients and demonstrating its safety remains under reported. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.034DOI Listing

The biographical gaze: Psychotherapeutic practice in psychosomatic hospitals in Germany.

Authors:
Sabine Flick

Soc Sci Med 2019 Mar 28;230:83-90. Epub 2019 Mar 28.

Goethe-Universität Frankfurt a.M. Institut für Soziologie, Theodor-W.-Adorno-Platz 6, 60323, Frankfurt, Germany. Electronic address:

This article introduces the concept of a "biographical gaze" based on two dimensions: On one hand, I draw on findings from my qualitative empirical research on psychotherapists' practice and their interpretation of patients' suffering. The case study was conducted in psychosomatic hospitals in Germany and focused on psychotherapists based on different kinds of data (supervision transcripts, interviews, medical records, and questionnaires). On the other hand, I connect this research with theories on the clinical gaze, as well as Bourdieu's critique of the "biographical illusion. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.03.037DOI Listing

The effects of exercise and milk-fat globule membrane (MFGM) on walking parameters in community-dwelling elderly Japanese women with declines in walking ability: A randomized placebo controlled trial.

Arch Gerontol Geriatr 2019 Apr 5;83:106-113. Epub 2019 Apr 5.

Institute of Gerontology, J.F. Oberlin University, Tokyo, Japan.

Objective: To investigate the effects of exercise and milk fat globule membrane (MFGM) supplementation on walking ability and walking parameters in community-dwelling elderly Japanese women with declined walking ability.

Methods: A randomized placebo controlled trial was performed on 126 elderly community-dwelling women over 79 years old. Participants were randomly assigned to one of four three-month interventions: exercise and MFGM (Ex + MFGM), exercise and placebo (Ex + P), MFGM, and placebo interventions. Read More

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http://dx.doi.org/10.1016/j.archger.2019.03.029DOI Listing

Association between self-reported hearing impairment, use of a hearing aid and performance of instrumental activities of daily living.

Arch Gerontol Geriatr 2019 Apr 6;83:101-105. Epub 2019 Apr 6.

Semillero de Neurociencias y Envejecimiento, Ageing Institute, Medical School, Pontificia Universidad Javeriana, Bogotá, Colombia; Geriatric Epidemiology Research Department, Instituto Nacional De Geriatría, México City, Mexico; Geriatric Medicine Research Unit, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address:

Background And Purpose: Age-related hearing loss is a prevalent condition among the growing elderly population, which has been associated with both cognitive decline and decreased daily functioning. Decreased functioning is linked to lower performance, predominantly regarding instrumental activities of daily living (IADLs). The present study aims to explore the association between hearing loss and impairment in IADLs. Read More

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http://dx.doi.org/10.1016/j.archger.2019.04.001DOI Listing

Akebia Saponin D inhibits the formation of atherosclerosis in ApoE mice by attenuating oxidative stress-induced apoptosis in endothelial cells.

Atherosclerosis 2019 Apr 10;285:23-30. Epub 2019 Apr 10.

Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China. Electronic address:

Background And Aims: Akebia Saponin D (ASD) is a major bioactive triterpenoid saponin compound isolated from the Chinese herb Dipsacus asper wall (DSW). DSW has been long used as an anti-Alzheimer disease and anti-osteoporosis agent in clinics. However, anti-atherosclerotic effects of ASD have not been fully investigated. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.04.202DOI Listing

Formulation, clinical and histopathological assessment of microemulsion based hydrogel for UV protection of skin.

Colloids Surf B Biointerfaces 2019 Apr 8;179:393-404. Epub 2019 Apr 8.

Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, P.O. Box: 91388-13944, Islamic Republic of Iran.

The aim of this study was to prepare a microemulsion based hydrogel containing sesame oil and evaluate its topical application in preventing the harmful effects of UV radiation on the guinea pig's skin using histopathologic and clinical findings. Sesame oil with high antioxidant content and unique chemical and physiological properties is a suitable candidate for the evolution of UV protection on skin. Applying this natural oil in microemulsion formulation containing particles with nanometer size can enhance its efficacy. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.04.015DOI Listing

Detecting pathological complete response in esophageal cancer after neoadjuvant therapy based on imaging techniques: a diagnostic systematic review and meta-analysis.

J Thorac Oncol 2019 Apr 15. Epub 2019 Apr 15.

Department of surgery.

Background: Up to 32% of patients with esophageal cancer show a pathological complete response (ypCR) after neoadjuvant therapy. In order to prevent overtreatment, the indication to perform esophagectomy in these patients should be reconsidered. Implementing an organ preserving strategy for patients with ypCR requires an accurate assessment of residual disease after neoadjuvant treatment. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.04.004DOI Listing
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