86,961 results match your criteria Medical Treatment of Stroke


Neurologic outcomes of carotid and other emergent interventions for ischemic stroke over six years with dataset enhanced by machine learning.

J Vasc Surg 2022 Jun 24. Epub 2022 Jun 24.

Section of Vascular/Endovascular Surgery, Department of Surgery, Ochsner Clinic Foundation, New Orleans, LA; The University of Queensland Faculty of Medicine, Ochsner Clinical School, New Orleans, LA USA. Electronic address:

Introduction: Current mainstays of ischemic stroke treatment include the use of thrombolysis (tissue plasminogen activator, tPA), urgent carotid endarterectomy (uCEA) or carotid artery stenting (uCAS), and mechanical endovascular reperfusion/thrombectomy (MER). Scarce data describe the presenting stroke severity and neurologic outcomes for these acute ischemic stroke interventions, alone or in combination. The authors hypothesize that patients undergoing carotid interventions experience better functional neurologic outcomes than other stroke interventions. Read More

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Safety and Efficacy of Ultra Short-Duration Dual Antiplatelet Therapy After Percutaneous Coronary Interventions: A Meta analysis of Randomized Controlled Trials.

Curr Probl Cardiol 2022 Jun 24:101295. Epub 2022 Jun 24.

Department of Clinical Medical Education, University of Tennessee at Nashville, Nashville, TN, USA; Ascension Healthcare Cardiovascular Service Line. Electronic address:

Introduction: Dual antiplatelet therapy (DAPT) is required after percutaneous coronary intervention (PCI) to reduce stent thrombosis, but DAPT increases bleeding risks. The optimal duration of DAPT that provides the maximum protective ischemic effect along with the minimum bleeding risk is unclear. This is the first meta-analysis comparing outcomes for 1-month versus longer DAPT strategies following PCI. Read More

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Omega-3 fatty acids, subclinical atherosclerosis, and cardiovascular events: Implications for primary prevention.

Atherosclerosis 2022 Jun 20;353:11-19. Epub 2022 Jun 20.

Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Johns Hopkins University School of Medicine, USA. Electronic address:

Background And Aims: High-dose eicosapentaenoic acid (EPA) therapy was beneficial in high-risk patients without clinical cardiovascular disease (CVD). Whether higher plasma levels of EPA and docosahexaenoic acid (DHA) have similar benefits in those without subclinical CVD is unclear. We aim to evaluate the interplay between plasma omega-3 fatty acids and coronary artery calcium (CAC) in relation to CVD events. Read More

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Thromboembolic complications of recreational nitrous oxide (ab)use: a systematic review.

J Thromb Thrombolysis 2022 Jun 27. Epub 2022 Jun 27.

Department of Radiology, Radiologist, Thoracic Imaging, Jessa Hospital, Hasselt, Belgium.

The recreatinal use of nitrous oxide has become more common in recent years, especially in adolescents and young adults. It has been mainly associated with medical conditions like megaloblastic anemia and (myelo)neuropathy. We report on the thromboembolic complications, a less known side effect, associated with recreational inhalation of nitrous oxide. Read More

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[Clinical case of MELAS syndrom].

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(6):152-158

Mechnikov North-Western State Medical University, St. Petersburg, Russia.

Clinical case of mitochondrial encephalomyopathy manifested with lactic acidosis and stroke-like episodes was presented. The patient diagnosis was performed in childhood, based on clinical manifestation, and was confirmed with molecular genetic test (mutation m.3243A>G in gene was revealed). Read More

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January 2022

USING THE SODA SCALE TO ASSESS THE EFFECTIVENESS OF NEUROLOGICAL SPEECH AND LANGUAGE THERAPY ON IMPROVING LANGUAGE FUNCTIONS IN POST-STROKE PATIENTS.

Wiad Lek 2022 ;75(5 pt 2):1229-1233

MEDICAL UNIVERSITY OF LODZ, LODZ, POLAND.

Objective: The aim: Assess the impact of neurological SLA on improvement of language functions in post-stroke patients.

Patients And Methods: Materials and methods: The study covered a total of 82 patients aged 40-80, of both sexes, with stroke-induced cognitive deficits. They were in-patients of the Clinic Of Rehabilitation And Physical Medicine of the "WAM" Teaching Hospital in Łódź. Read More

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January 2022

Management strategies of unanticipated intracranial stenosis during mechanical thrombectomy for acute stroke: A survey of academic neurointerventionalists.

Interv Neuroradiol 2022 Jun 26:15910199221110971. Epub 2022 Jun 26.

Department of Neurosurgery, 3989Baylor College of Medicine, Houston, TX, USA.

Background: The optimal approach to the management of intracranial atherosclerotic disease (ICAD) at the time of mechanical thrombectomy (MT) for large vessel occlusion (LVO) remains controversial. The goal of this study is to characterize current practices concerning this challenging clinical situation in a survey of practicing neurointerventionalists.

Methods: An electronic questionnaire was sent to a cross-section of North American academic neurointerventionalists using publicly available contact information and departmental websites. Read More

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Remodeling of T Cell Dynamics During Long COVID Is Dependent on Severity of SARS-CoV-2 Infection.

Front Immunol 2022 10;13:886431. Epub 2022 Jun 10.

Laboratory of Cytometry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.

Several COVID-19 convalescents suffer from the post-acute COVID-syndrome (PACS)/long COVID, with symptoms that include fatigue, dyspnea, pulmonary fibrosis, cognitive dysfunctions or even stroke. Given the scale of the worldwide infections, the long-term recovery and the integrative health-care in the nearest future, it is critical to understand the cellular and molecular mechanisms as well as possible predictors of the longitudinal post-COVID-19 responses in convalescent individuals. The immune system and T cell alterations are proposed as drivers of post-acute COVID syndrome. Read More

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Preferences for and use of oral anticoagulants for stroke prevention in atrial fibrillation under real-world conditions in Germany: A survey among physicians.

Prev Med Rep 2022 Aug 13;28:101861. Epub 2022 Jun 13.

IGES Institut GmbH, Friedrichstr. 180, 10117 Berlin, Germany.

In Germany, there is little real-world evidence on physicians' choice of oral anticoagulants (OACs). Our study aimed at assessing preferences for and prescribing patterns of treatment options for stroke prevention in atrial fibrillation in clinical practice in Germany. We conducted a nationwide quantitative online survey among office-based physicians in Germany. Read More

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Convulsive-like symptoms as initial indications of basilar artery occlusion: A case series study.

eNeurologicalSci 2022 Sep 16;28:100410. Epub 2022 Jun 16.

Department of Neurosurgery, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.

Background: There is little evidence regarding relevant clinical findings for the early diagnosis of basilar artery occlusion (BAO) in the prehospital setting. We focused on "convulsive-like symptoms", including convulsive seizures and other convulsive-like movements, and examined the frequency and clinical characteristics of patients with BAO having these symptoms as an initial symptom.

Methods: In this single-center case series from 2015 to 2020, we identified patients who underwent endovascular therapy (EVT) for BAO and presented with convulsive-like symptoms between the stroke onset and initiation of emergency medical care. Read More

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September 2022

MRI Assessment of Cardiac Function and Morphology in Adult Patients With Growth Hormone Deficiency: A Systematic Review and Meta-Analysis.

Front Endocrinol (Lausanne) 2022 10;13:910575. Epub 2022 Jun 10.

Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy.

Background: Adult GH deficiency (GHD) has been described as a heterogeneous condition characterized by many clinical modifications, such as metabolic alterations, impaired quality of life, and increased mortality. The clinical relevance of cardiac involvement remains, however, only partially elucidated.

Methods: PubMed/Medline, EMBASE, Cochrane library, OVID and CINAHL databases were systematically searched until February 2022 for studies evaluating cardiac function and morphology by magnetic resonance imaging in adult patients with GHD. Read More

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Impact of Prasugrel and Ticagrelor on Platelet Reactivity in Patients With Acute Coronary Syndrome: A Meta-Analysis.

Front Cardiovasc Med 2022 9;9:905607. Epub 2022 Jun 9.

National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Background: This meta-analysis mainly aimed to compare the impact of prasugrel and ticagrelor on platelet reactivity (PR) in patients with acute coronary syndrome (ACS).

Methods: We searched four electronic databases to identify randomized controlled trials and cohort studies comparing the impact of prasugrel and ticagrelor on PR in patients with ACS. We performed group analyses according to three detection methods, drug dose [loading dose (LD) and maintenance dose (MTD)] and LD effect time, and assessed the robustness of the results through sensitivity analysis. Read More

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Insights Into Platelet-Derived MicroRNAs in Cardiovascular and Oncologic Diseases: Potential Predictor and Therapeutic Target.

Front Cardiovasc Med 2022 9;9:879351. Epub 2022 Jun 9.

Division of Cardiology, Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Non-communicable diseases (NCDs), represented by cardiovascular diseases and cancer, have been the leading cause of death globally. Improvements in mortality from cardiovascular (CV) diseases (decrease of 14%/100,000, United States) or cancers (increase 7.5%/100,000, United States) seem unsatisfactory during the past two decades, and so the search for innovative and accurate biomarkers of early diagnosis and prevention, and novel treatment strategies is a valuable clinical and economic endeavor. Read More

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Association Between Temporal Asymmetry and Muscle Synergy During Walking With Rhythmic Auditory Cueing in Survivors of Stroke Living With Impairments.

Arch Rehabil Res Clin Transl 2022 Jun 24;4(2):100187. Epub 2022 Feb 24.

Department of Neurorehabilitation, Graduate School of Health Sciences, Kio University, Nara, Japan.

Objective: To examine the relationship between temporal asymmetry and complexity of muscle synergy during walking using rhythmic auditory cueing (RAC) and the factors related to changes in muscle synergy during walking with RAC in survivors of stroke.

Design: Cross-sectional study.

Setting: Wards at 2 medical corporation hospitals. Read More

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Use of Patient-Reported Outcomes Measurement Information System Measures in Clinical Research in Patients With Stroke: A Systematic Literature Review.

Arch Rehabil Res Clin Transl 2022 Jun 25;4(2):100191. Epub 2022 Mar 25.

Department of Orthopedics, Rehabilitation, and Physical Therapy, Leiden University Medical Center, Leiden, the Netherlands.

Objective: To systematically describe the use and outcomes of Patient-Reported Outcomes Measurement Information System (PROMIS) measures in clinical studies in populations with stroke.

Data Sources: A systematic search on the use of PROMIS measures in clinical stroke studies in 9 electronic databases.

Study Selection: Studies had to be original, reporting on outcome data using PROMIS measures in populations with stroke (ischemic and/or hemorrhagic), from January 1st, 2007. Read More

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Non-pulmonary complications after lung transplantation: Part I.

Indian J Thorac Cardiovasc Surg 2022 Jul 8;38(Suppl 2):280-289. Epub 2021 Oct 8.

Lung Transplant Program, University of Texas Southwestern Medical Center, 5939 Harry Hines Blvd. Suite 603, Dallas, TX 75235-8550 USA.

Lung transplantation (LT) is a viable therapeutic option in the treatment of advanced lung disease. With improvements in post-transplant survival, complications involving different organ systems after LT are increasingly seen. While non-infectious, extrapulmonary complications after LT are not frequently responsible for early post-transplant mortality, they significantly impact the quality of life and long-term survival. Read More

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A Prospective, Multicenter, Single-Group Target-Value Clinical Trial to Evaluate the Safety and Efficacy of a Large Bore Aspiration Catheter System for the Endovascular Treatment of Acute Ischemic Stroke.

Front Neurol 2022 9;13:864563. Epub 2022 Jun 9.

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Objective: This study was conducted to determine the safety and efficacy of the Esperance Distal Access Catheter (0.071"), a novel large bore aspiration catheter in treating acute ischemic stroke (AIS) with large vessel occlusion (LVO).

Methods: A prospective multicenter clinical trial involving 15 stroke centers was performed. Read More

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A Review of the Advancements in the Modelling of Acute Ischemic Stroke and Its Treatment.

Front Med Technol 2022 8;4:879074. Epub 2022 Jun 8.

Cerenovus (Johnson & Johnson), Galway Neuro Technology Centre, Galway, Ireland.

neurovascular models of large vessel occlusions (LVOs) causing acute ischemic stroke (AIS) are used extensively for pre-clinical testing of new treatment devices. They enable physicians and engineers to examine device performance and the response of the occlusion to further advance design solutions for current unmet clinical needs. These models also enable physicians to train on basic skills, to try out new devices and new procedural approaches, and for the stroke team to practice workflows together in the comfort of a controlled environment in a non-clinical setting. Read More

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Roles of Micro Ribonucleic Acids in Astrocytes After Cerebral Stroke.

Front Cell Neurosci 2022 9;16:890762. Epub 2022 Jun 9.

Department of Neurosurgery, The Affiliated Hospital of Medical College, Kunming University of Science and Technology, The First People's Hospital of Yunnan Province, Kunming, China.

Cerebral stroke is one of the highest-ranking causes of death and the leading cause of disability globally, particularly with an increasing incidence and prevalence in developing countries. Steadily more evidence has indicated that micro ribonucleic acids (miRNAs) have important regulatory functions in gene transcription and translation in the course of cerebral stroke. It is beyond arduous to understand the pathophysiology of cerebral stroke, due in part to the perplexity of influencing the network of the inflammatory response, brain edema, autophagy and neuronal apoptosis. Read More

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Diabetes Mellitus and Related Admission Factors Among Hospitalized Patients in King Abdul-Aziz University Hospital in Jeddah, Saudi Arabia.

Cureus 2022 May 25;14(5):e25312. Epub 2022 May 25.

Internal Medicine, King Abdul-Aziz University, Jeddah, SAU.

Background Diabetes mellitus (DM) is a rapidly increasing serious health problem that affects the population all over the world. The increasing prevalence of DM in Saudi Arabia is reflected in our hospital admissions as well. This study aimed to assess the proportion of DM (including type 1 and type 2 diabetes) among hospitalized patients and the reasons for admissions to the medical unit at King Abdul-Aziz University Hospital (KAUH) in Jeddah, Saudi Arabia. Read More

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Aortic Thrombosis and Ischemic Stroke With Hemorrhagic Conversion in a Patient With Remote COVID-19 Infection: A Treatment Dilemma.

Cureus 2022 May 24;14(5):e25272. Epub 2022 May 24.

Internal Medicine, Icahn School of Medicine at Mount Sinai Beth Israel, New York, USA.

Coronavirus disease 2019 (COVID-19) is primarily known to affect the lungs; however, several studies indicate that it can be a multisystem disease. There is documentation detailing different sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients affected with this virus have been seen to develop a hypercoagulable state leading to systemic thrombosis in some cases or embolism leading to catastrophic outcomes in others. Read More

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Web Browsing: High-Speed Diagnosis and Treatment of Carotid Artery Web.

Neurohospitalist 2022 Jul 5;12(3):498-503. Epub 2022 May 5.

Department of Neurology, University of South Florida Morsani College of Medicine, Tampa, FL,USA.

Although carotid artery web (CaW) was initially described in 1973 as a potential etiology of ischemic stroke, it still remains underrecognized. Because CaW is a membrane affixed perpendicularly from the carotid wall that projects out into the lumen above the bifurcation, it typically is not stenotic, and hence, utilizing only 1 vessel imaging modality during conventional stroke workup may instead lead to a diagnosis of ESUS: embolic stroke of undetermined source. The term ESUS was created in 2014 by researchers to define a subset of cryptogenic, nonlacunar (embolic-appearing) strokes without clear cardiac or vascular cause. Read More

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Concurrent Coronary, Left Ventricle, and Cerebral Thrombosis - A Trilogy.

Int J Appl Basic Med Res 2022 Apr-Jun;12(2):130-133. Epub 2022 May 10.

Departments of Cardiology, King George's Medical University, Lucknow, Uttar Pradesh, India.

Left ventricular (LV) thrombus is a known complication of acute myocardial infarction (AMI), especially anterior wall MI and leads to systemic thromboembolism. However, increase in the rates of coronary perfusion either by thrombolysis or percutaneous interventions have reduced its incidence. Concurrent stroke and MI are seen in 0. Read More

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Auditory-motor mapping training: Testing an intonation-based spoken language treatment for minimally verbal children with autism spectrum disorder.

Ann N Y Acad Sci 2022 Jun 26. Epub 2022 Jun 26.

Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA.

We tested an intonation-based speech treatment for minimally verbal children with autism (auditory-motor mapping training, AMMT) against a nonintonation-based control treatment (speech repetition therapy, SRT). AMMT involves singing, rather than speaking, two-syllable words or phrases. In time with each sung syllable, therapist and child tap together on electronic drums tuned to the same pitches, thus coactivating shared auditory and motor neural representations of manual and vocal actions, and mimicking the "babbling and banging" stage of typical development. Read More

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Acute embolic stroke with large-vessel occlusion: does contact aspiration thrombectomy show superiority?

Clin Radiol 2022 Jun 23. Epub 2022 Jun 23.

Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China. Electronic address:

Aim: To compare the efficacy between contact aspiration thrombectomy and stent retriever thrombectomy in the treatment of acute embolic stroke patients with large vessel occlusion.

Materials And Methods: Between January 2019 and June 2020, data from consecutive acute ischaemic stroke patients who underwent either endovascular contact aspiration or stent retriever thrombectomy were analysed at one institution. The primary outcome was the full 90-day modified Rankin Scale (mRS) score. Read More

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Spatial distribution of stroke readmission within 30 days and the influencing factors in Hunan Province.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 May;47(5):619-627

Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078.

Objectives: Stroke readmission increases financial burden on the family and the consumption of medical resources, and 30-day readmission rate is an important indicator for quality evaluation on health services. The influential factors for readmission mainly include patient-related factors, hospital factors, and society-related factors, with regional differences. This study aims to explore the spatial distribution and its main relevant factors for 30-day readmission of stroke patients in Hunan Province, and to provide the useful information for the improvement of regional prevention and control of stroke readmission. Read More

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Dexmedetomidine exerts its protective effect on cerebral ischemia reperfusion injury in mice by inhibiting ferroptosis.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 May;47(5):600-609

Department of Pharmacology, School of Pharmacy, Bengbu Medical College, Bengbu Anhui 233030.

Objectives: Stroke is one of the major diseases that can threaten human life and health. The incidence of ischemic stroke accounts for more than 70% of stroke. The mechanism of ischemia reperfusion (IR) injury caused by ischemic stroke is extremely complex. Read More

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Acute SGLT-2i treatment improves cardiac efficiency during myocardial ischemia independent of Na+/H+ exchanger-1.

Int J Cardiol 2022 Jun 23. Epub 2022 Jun 23.

Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, United States of America. Electronic address:

Aims: Sodium glucose co-transporter 2 inhibitors (SGLT2i) demonstrate cardioprotective benefits independent of a glucose lowering effect including preservation of cardiac function during a myocardial ischemia. Sodium‑hydrogen exchanger-1 (NHE-1), has been hypothesized to contribute to the cardiac effects of SGLT2i. We characterized the beneficial effects of acute pre-ischemia exposure to SGLT2i and explored the possibility that these effects are explained by NHE-1 inhibition. Read More

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Paired Associative Stimulation Applied to the Cortex can Increase Resting-state Functional Connectivity: A Proof-of-Principle Study.

Neurosci Lett 2022 Jun 23:136753. Epub 2022 Jun 23.

Division of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Introduction: There is emerging evidence that high Beta coherence (hBc) between prefrontal and motor corticies, measured with resting-state electroencephalography (rs-EEG), can be an accurate predictor of motor skill learning and stroke recovery. However, it remains unknown whether and how intracortical connectivity may be influenced using neuromodulation. Therefore, a cortico-cortico PAS (ccPAS) paradigm may be used to increase resting-state intracortical connectivity (rs-IC) within a targeted neural circuit. Read More

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