66,593 results match your criteria Medical Treatment of Stroke


Intravenous Thrombolysis Is Not Associated with Increased Time to Endovascular Treatment.

Cerebrovasc Dis 2020 Jul 2:1-7. Epub 2020 Jul 2.

Department of Neurology, St. Antonius Hospital, Nieuwegein, The Netherlands.

Background: Endovascular treatment (EVT) with or without intravenous thrombolysis (IVT) is effective and safe in is-chemic stroke caused by large vessel occlusion, but IVT might delay time to EVT or increase risk of intracranial hemorrhage (ICH). We assessed the influence of prior IVT on time to treatment and risk of ICH in patients treated with EVT.

Methods: We analyzed data from the MR CLEAN Registry and included patients with an anterior circulation occlusion treated with EVT who presented directly to an intervention center, between 2014 and 2017. Read More

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http://dx.doi.org/10.1159/000508898DOI Listing

Enhanced white matter reorganization and activated brain glucose metabolism by enriched environment following ischemic stroke: Micro PET/CT and MRI study.

Neuropharmacology 2020 Jun 29:108202. Epub 2020 Jun 29.

School of Traditional Chinese Medicine, Capital Medical University, Beijing, China; Beijing Key Lab of TCM Collateral Disease Theory Research, Beijing, China. Electronic address:

Enriched environment (EE) is an effective rehabilitative protocol designed to enhance sensorimotor, cognitive and social stimulation. Current understanding of neuronal remodeling after EE intervention mainly derived from conventional histological methods. The efficacy of EE treatment on post-stroke brain reorganization still needed to be elucidated in vivo. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2020.108202DOI Listing

Risk of chronic kidney disease in patients with heat injury: A nationwide longitudinal cohort study in Taiwan.

PLoS One 2020 2;15(7):e0235607. Epub 2020 Jul 2.

Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Global climate change has led to a significant increase in temperature over the last century and has been associated with significant increases in the severity and frequency of heat injury (HI). The consequences of HI included dehydration and rhabdomyolysis, leading to acute kidney injury, which is now recognized as a clear risk factor for chronic kidney disease (CKD). We aimed to investigate the effects of HI on the risk of CKD. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235607PLOS

The utilization of intravascular lithotripsy to facilitate transcarotid artery stenting in a nonagenarian patient.

J Cardiovasc Surg (Torino) 2020 Jul 1. Epub 2020 Jul 1.

Division of Vascular and Endovascular Surgery, University of Colorado, Anschutz Medical Center, Aurora, CO, USA.

Carotid artery disease and stroke account for the second cause of mortality in worldwide. Recently, transcarotid artery stenting (TCAR) has emerged as a treatment modality that carries the lowest a very low stroke rate. However, there are limitations to TCAR, such as heavily calcified plaques that might preclude optimal stent expansion. Read More

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http://dx.doi.org/10.23736/S0021-9509.20.11421-6DOI Listing

Characteristics and 2-year outcomes of dabigatran treatment in patients with heart failure and atrial fibrillation: GLORIA-AF.

ESC Heart Fail 2020 Jul 2. Epub 2020 Jul 2.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK.

Aims: This study aimed to describe baseline characteristics of patients with atrial fibrillation (AF) at risk of stroke with and without history of heart failure (HF) and report 2-year outcomes in the dabigatran-treated subset of a prospective, global, observational study (GLORIA-AF).

Methods And Results: Newly diagnosed patients with AF and CHA DS -VASc score ≥ 1 were consecutively enrolled. Baseline characteristics were assessed by the presence or absence of HF diagnosis at enrolment. Read More

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http://dx.doi.org/10.1002/ehf2.12857DOI Listing

Neuroprotective Cationic Arginine-Rich Peptides (CARPs): An Assessment of Their Clinical Safety.

Drug Saf 2020 Jul 1. Epub 2020 Jul 1.

Perron Institute for Neurological and Translational Sciences, First Floor, RR Block, QEII Medical Centre, Nedlands, WA, Australia.

Cationic arginine-rich peptides represent a novel class of peptides being developed as neuroprotective agents for stroke and other acute and chronic neurological disorders. As a group, cationic arginine-rich peptides have a diverse range of other biological properties including the ability to traverse cell membranes, modulate immune responses, antagonise ion channel receptor function, as well as possessing cardioprotective, anti-nociceptive, anti-microbial and anti-cancer properties. A sound understanding of their safety profile is essential for the design of future clinical trials and for ensuring translational success with these compounds. Read More

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http://dx.doi.org/10.1007/s40264-020-00962-zDOI Listing

Apolipoprotein E knockout rabbit model of intracranial atherosclerotic disease.

Animal Model Exp Med 2020 Jun 21;3(2):208-213. Epub 2020 Jun 21.

Department of Radiology and Imaging Sciences University of Utah Salt Lake City UT USA.

Intracranial atherosclerotic disease (ICAD) is the most common cause of ischemic stroke. Poor understanding of the disease due to limited human data leads to imprecise treatment. Apolipoprotein E knockout (ApoE-KO) rabbits were compared to an existing model, the Watanabe heritable hyperlipidemic (WHHL) rabbit, and wild-type New Zealand white (NZW) rabbit controls. Read More

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http://dx.doi.org/10.1002/ame2.12125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323697PMC

Safety and Efficacy of Tirofiban in Rescue Treatment for Acute Intracranial Intraprocedural Stent Thrombosis.

Front Neurol 2020 16;11:492. Epub 2020 Jun 16.

Department of Neurology, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

The incidence of acute intraprocedural stent thrombosis (AIST) during stenting of intracranial atherosclerotic stenosis (ICAS) has seldom been reported and evidence regarding the treatment of AIST is lacking. We aim to investigate the incidence of AIST during stenting of ICAS in our institute, assess the preliminary efficacy and safety of rescue treatment of tirofiban for these patients. From September 2016 to May 2019, all symptomatic ICAS patients who underwent intracranial stenting in our institute were prospectively registered into this study, of which patients with AIST were retrospectively reviewed to extract baseline characteristics, perioperative management, procedural details, angiographic, and clinical outcomes. Read More

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http://dx.doi.org/10.3389/fneur.2020.00492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308481PMC

Peripheral and Central Nervous System Immune Response Crosstalk in Amyotrophic Lateral Sclerosis.

Front Neurosci 2020 16;14:575. Epub 2020 Jun 16.

Department of Neurology, The First Hospital of China Medical University, Shenyang, China.

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by muscle weakness due to the degeneration of the upper and lower motor neurons. Neuroinflammation is known as a prominent pathological feature of ALS. Although neuroinflammation cannot trigger ALS, activated central nervous system (CNS) microglia and astrocytes, proinflammatory periphery monocytes/macrophages and T lymphocytes, and infiltrated monocytes/macrophages and T lymphocytes, as well as the immunoreactive molecules they release, are closely related to disease progression. Read More

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http://dx.doi.org/10.3389/fnins.2020.00575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308438PMC

Recent Strategies for Targeted Brain Drug Delivery.

Chem Pharm Bull (Tokyo) 2020 ;68(7):567-582

Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University.

Because the brain is the most important human organ, many brain disorders can cause severe symptoms. For example, glioma, one type of brain tumor, is progressive and lethal, while neurodegenerative diseases cause severe disability. Nevertheless, medical treatment for brain diseases remains unsatisfactory, and therefore innovative therapies are desired. Read More

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http://dx.doi.org/10.1248/cpb.c20-00041DOI Listing
January 2020

Efficacy and safety of an antithrombotic regimen for atrial fibrillation patients with acute coronary syndrome or those undergoing percutaneous coronary intervention: a meta-analysis.

Aging (Albany NY) 2020 Jul 1;12. Epub 2020 Jul 1.

Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

This study evaluated the benefit of dual therapy in reducing ischemic events in atrial fibrillation (AF) patients presenting with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI). We searched PubMed, Cochrane Library, and ClinicalTrials.gov for randomized controlled trials (RCTs) comparing dual and triple therapies (oral anticoagulation plus aspirin and P2Y12 inhibitor) for AF patients with ACS or those undergoing PCI. Read More

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http://dx.doi.org/10.18632/aging.103359DOI Listing

Who may benefit from lower dosages of intravenous tissue plasminogen activator? Results from a cluster data analysis.

Stroke Vasc Neurol 2020 Jul 1. Epub 2020 Jul 1.

Department of Neurology, Huashan Hospital Fudan University, Shanghai, Shanghai, China

Background: The risk of symptomatic intracranial haemorrhage (sICH) after thrombolysis is low but severe. Lower dose of alteplase may reduce the risk of sICH. We aim to identify subsets of patients who could benefit from lower dose of alteplase compared with standard dose. Read More

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http://dx.doi.org/10.1136/svn-2020-000388DOI Listing

The association between endocrine therapy use and dementia among post-menopausal women treated for early-stage breast cancer in Ontario, Canada.

J Geriatr Oncol 2020 Jun 28. Epub 2020 Jun 28.

Division of Medical Oncology, Sunnybrook Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; ICES Central, Toronto, Ontario, Canada.

Purpose: The association between endocrine therapy and risk of dementia remains uncertain. We investigated the association between adjuvant endocrine therapy for breast cancer and risk of developing dementia in a real-world, population-based study.

Methods: We used health administrative data collected from post-menopausal women (aged ≥66 years) who were diagnosed with breast cancer and started on adjuvant endocrine therapy from 2005 to 2012 with follow-up until 2017. Read More

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http://dx.doi.org/10.1016/j.jgo.2020.05.009DOI Listing

Different predictors after stroke depending on functional dependency at discharge: a 5-year follow up study.

BMC Neurol 2020 Jul 1;20(1):263. Epub 2020 Jul 1.

Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy, Sahlgrenska University Hospital, Per Dubbsgatan 14, 413 45, Gothenburg, Sweden.

Background: Level of dependency after a stroke is important for long-term outcome in several aspects, but less is known about important predictors for outcome depending on functional dependency. The aim of the current study was to investigate self-perceived outcome and identify possible predictors of strength, participation, and emotional outcome 5 years after stroke based on functional dependency at discharge from hospital.

Methods: This observational cohort study included participants living in Gothenburg that were diagnosed with first ever stroke in 2009 and 2010. Read More

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http://dx.doi.org/10.1186/s12883-020-01840-yDOI Listing

Correction to: Differences in factors influencing the use of eRehabilitation after stroke; a cross-sectional comparison between Brazilian and Dutch healthcare professionals.

BMC Health Serv Res 2020 Jul 1;20(1):607. Epub 2020 Jul 1.

Department of Orthopaedics, Rehabilitation and Physical Therapy, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands.

An amendment to this paper has been published and can be accessed via the original article. Read More

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http://dx.doi.org/10.1186/s12913-020-05457-2DOI Listing

Alteplase for Acute Ischemic Stroke in Patients Aged >80 Years: Pooled Analyses of Individual Patient Data.

Stroke 2020 Jul 2:STROKEAHA119028396. Epub 2020 Jul 2.

The School of Medicine, Dentistry & Nursing, University of Glasgow, United Kingdom (K.R.L.).

Background/purpose: Expert guidelines specify no upper age limit for alteplase for thrombolysis of acute ischemic stroke (AIS) but, until recently, European regulatory criteria restricted its use to patients aged 18 to 80 years. We performed pooled analyses of randomized controlled trial (RCT) and registry data to evaluate the benefit-risk profile of alteplase for AIS among patients aged >80 years to support a regulatory application to lift the upper age restriction.

Methods: Individual patient data were evaluated from 7 randomized trials of alteplase (0. Read More

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http://dx.doi.org/10.1161/STROKEAHA.119.028396DOI Listing

Cangrelor dose titration using platelet function testing during cerebrovascular stent placement.

Interv Neuroradiol 2020 Jul 1:1591019920936923. Epub 2020 Jul 1.

Department of Neurosurgery, Albany Medical Center, Albany, NY, USA.

Background: Optimal antiplatelet inhibition is vital during cerebrovascular stenting procedures, yet no standardized recommendation exists for antithrombotic therapy in these scenarios. Cangrelor is an intravenous P2Y12 inhibitor with a favorable pharmacokinetic profile for use during neuroendovascular stenting.

Methods: A retrospective review of all neuroendovascular patients who underwent stenting between 1 January 2019 and 22 March 2020 and were treated with cangrelor was conducted. Read More

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http://dx.doi.org/10.1177/1591019920936923DOI Listing

An overview of lower limb cellulitis in an acute medical ward-a few lessons we can learn.

Acute Med 2019 ;18(1):8-13

MD (Canada), MMED (Singapore), MRCP (UK), FAMS, Department of Internal Medicine, Singapore General Hospital.

Lower limb cellulitis is a common cause for hospital admissions. In this retrospective study, we assessed the characteristics and outcome of patients admitted in an acute medical unit. The mean duration of treatment was 10. Read More

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January 2019

Ultrasonography of vulnerable atherosclerotic plaque in the carotid arteries: B-mode imaging.

J Ultrason 2020 15;20(81):e135-e145. Epub 2020 Jun 15.

Department of Radiology, Jagiellonian University Medical College , Krakow , Poland.

The most common type of stroke, i.e. ischemic stroke, is a great challenge for contemporary medicine as it poses both diagnostic and therapeutic difficulties. Read More

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http://dx.doi.org/10.15557/JoU.2020.0022DOI Listing

Guideline Recommendations for Oral Care After Acquired Brain Injury: Protocol for a Systematic Review.

JMIR Res Protoc 2020 Jul 1;9(7):e17249. Epub 2020 Jul 1.

School of Rehabilitation Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada.

Background: Oral care is important to prevent buccal and systemic infections after an acquired brain injury (ABI). Despite recent advancements in the development of ABI clinical practice guidelines, recommendations for specific clinical processes and actions to attain adequate oral care often lack information.

Objective: This systematic review will (1) identify relevant ABI clinical practice guidelines and (2) appraise the oral care recommendations existing in the selected guidelines. Read More

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http://dx.doi.org/10.2196/17249DOI Listing

Can Clinical and Functional Outcomes Be Improved with an Intelligent "Internet Plus"-Based Full Disease Cycle Remote Ischemic Conditioning Program in Acute ST-elevation Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention? Rationale and Design of the i-RIC Trial.

Cardiovasc Drugs Ther 2020 Jun 30. Epub 2020 Jun 30.

Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing, 210029, China.

Background: Acute ST-elevation myocardial infarction (STEMI) is associated with a high incidence of complications as well as a considerable hospitalization rate and economic burden. Preliminary evidence suggests that remote ischemic conditioning (RIC) is a promising non-invasive intervention that may effectively and safely reduce myocardial infarct size, subsequent cardiac events and complications, and mortality. However, RIC's cardio-protective effect remains under debate, especially for single timepoint RIC programs. Read More

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http://dx.doi.org/10.1007/s10557-020-07022-9DOI Listing

Sex differences in aneurysmal subarachnoid haemorrhage (aSAH): aneurysm characteristics, neurological complications, and outcome.

Acta Neurochir (Wien) 2020 Jun 30. Epub 2020 Jun 30.

Menzies Institute for Medical Research, Hobart, Tasmania, University of Tasmania, Hobart, Australia.

Background: Women are over-represented in aSAH cohorts, but whether their outcomes differ to men remains unclear. We examined if sex differences in neurological complications and aneurysm characteristics contributed to aSAH outcomes.

Methods: In a retrospective cohort (2010-2016) of all aSAH cases across two hospital networks in Australia, information on severity, aneurysm characteristics and neurological complications (rebleed before/after treatment, postoperative stroke < 48 h, neurological infections, hydrocephalus, seizures, delayed cerebral ischemia [DCI], cerebral infarction) were extracted. Read More

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http://dx.doi.org/10.1007/s00701-020-04469-5DOI Listing

Thrombolysis beyond 4.5 h in Acute Ischemic Stroke.

Curr Neurol Neurosci Rep 2020 Jun 30;20(8):35. Epub 2020 Jun 30.

JPK Stroke Research Center, Department of Neurology, Massachusetts General Hospital (MGH) and Harvard Medical School, Boston, MA, USA.

Purpose Of Review: The purpose of this article is to review the current approaches using neuroimaging techniques to expand eligibility for intravenous thrombolytic therapy in acute ischemic stroke patients with stroke of unknown symptom onset.

Recent Findings: In recent years, several randomized, placebo-controlled trials have shown neuroimaging-guided approaches to be feasible in determining eligibility for alteplase beyond 4.5 h from last known well, and efficacious for reducing disability. Read More

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http://dx.doi.org/10.1007/s11910-020-01055-1DOI Listing

Comparison of Risk Factors, Treatment, and Outcome in Patients with Symptomatic Intracranial Atherosclerotic Disease in India and the United States.

Ann Indian Acad Neurol 2020 May-Jun;23(3):265-269. Epub 2020 Jun 5.

Comprehensive Stroke Care Program, Department of Neurology, Sree ChitraTirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.

Background And Aims: Intracranial atherosclerotic disease (ICAD) is common in the Asian population, but less studied in South Asians compared to East Asians. We compared risk factors, treatments, and outcomes among consecutive patients with symptomatic ICAD from India with a mixed-ethnic cohort from Chicago, Illinois.

Methods: Consecutive patients with symptomatic ICAD were enrolled at 2 academic medical centers in Kerala, India and Chicago, United States. Read More

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http://dx.doi.org/10.4103/aian.AIAN_549_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313562PMC

Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties.

Nat Commun 2020 Jun 30;11(1):3279. Epub 2020 Jun 30.

Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA, USA.

Recombinant adeno-associated viruses (rAAVs) are currently considered the safest and most reliable gene delivery vehicles for human gene therapy. Three serotype capsids, AAV1, AAV2, and AAV9, have been approved for commercial use in patients, but they may not be suitable for all therapeutic contexts. Here, we describe a novel capsid identified in a human clinical sample by high-throughput, long-read sequencing. Read More

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http://dx.doi.org/10.1038/s41467-020-17047-1DOI Listing

Zoster sine herpete: a review.

Korean J Pain 2020 Jul;33(3):208-215

Department of Pain Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Zoster sine herpete (ZSH) is one of the atypical clinical manifestations of herpes zoster (HZ), which stems from infection and reactivation of the varicella-zoster virus (VZV) in the cranial nerve, spinal nerve, viscera, or autonomic nerve. Patients with ZSH display variable symptoms, such as neuralgia, however, different from HZ, ZSH show no zoster, which makes clinical diagnosis difficult. ZSH not only causes initial symptoms, such as neuropathic pain in the affected nerve, Bell palsy, and Ramsay Hunt syndrome, but also postherpetic neuralgia and fatal complications such as VZV encephalitis and stroke. Read More

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http://dx.doi.org/10.3344/kjp.2020.33.3.208DOI Listing

Neuroendovascular clinical trials disruptions due to COVID-19 potential future challenges and opportunities.

J Neurointerv Surg 2020 Jun 30. Epub 2020 Jun 30.

Department of Neurosurgery, Gates Vascular Institute at Kaleida Health, Buffalo, New York, USA.

To assess the impact of COVID-19 on neurovascular research and deal with the challenges imposed by the pandemic.

Methods: A survey-based study focused on randomized controlled trials (RCTs) and single-arm studies for acute ischemic stroke and cerebral aneurysms was developed by a group of senior neurointerventionalists and sent to sites identified through the clinical trials website (https://clinicaltrials.gov/), study sponsors, and physician investigators. Read More

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http://dx.doi.org/10.1136/neurintsurg-2020-016502DOI Listing

Emergency medical services use and its association with acute ischaemic stroke evaluation and treatment in Singapore.

Stroke Vasc Neurol 2020 Jun 8;5(2):121-127. Epub 2020 Apr 8.

Department of Neurology, National Neuroscience Institute-Singapore General Hospital Campus, Singapore.

Background: Emergency medical services (EMS) is a critical link in the chain of stroke survival. We aimed to assess EMS use for stroke in Singapore, identify characteristics associated with EMS use and the association of EMS use with stroke evaluation and treatment.

Methods: The Singapore Stroke Registry combines nationwide EMS and public hospital data for stroke cases in Singapore. Read More

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http://dx.doi.org/10.1136/svn-2019-000277DOI Listing

Nonusefulness of Antithrombotic Therapy After Surgical Bioprosthetic Aortic Valve Replacement.

Am J Cardiol 2020 May 18. Epub 2020 May 18.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut. Electronic address:

Controversy persists regarding the advisability of anticoagulation for the early period after biological surgical aortic valve replacement (AVR). We aim to examine the impact of various antithrombotic regimens on outcomes in a large cohort of biological AVR patients. Records of 1,111 consecutive adult patients who underwent surgical biological AVR at our institution between 2013 and 2017 were reviewed. Read More

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http://dx.doi.org/10.1016/j.amjcard.2020.05.018DOI Listing
May 2020
3.276 Impact Factor

Androgens' effects on cerebrovascular function in health and disease.

Biol Sex Differ 2020 Jun 30;11(1):35. Epub 2020 Jun 30.

Department of Neuroscience & Experimental Therapeutics, Albany Medical College, 47 New Scotland Avenue, MC-136, Albany, NY, 12208, USA.

Androgens affect the cerebral vasculature and may contribute to sex differences in cerebrovascular diseases. Men are at a greater risk for stroke and vascular contributions to cognitive impairment and dementia (VCID) compared to women throughout much of the lifespan. The cerebral vasculature is a target for direct androgen actions, as it expresses several sex steroid receptors and metabolizing enzymes. Read More

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http://dx.doi.org/10.1186/s13293-020-00309-4DOI Listing

Systematic review with network meta-analysis of randomized controlled trials of robotic-assisted arm training for improving activities of daily living and upper limb function after stroke.

J Neuroeng Rehabil 2020 Jun 30;17(1):83. Epub 2020 Jun 30.

Department of Public Health, Dresden Medical School, Technical University Dresden, Dresden, Germany.

Background: The aim of the present study was to to assess the relative effectiveness of the various types of electromechanical-assisted arm devices and approaches after stroke.

Method: This is a systematic review of randomized controlled trials with network meta-analysis. Our primary endpoints were activities of daily living (measured e. Read More

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http://dx.doi.org/10.1186/s12984-020-00715-0DOI Listing

Growth Hormone Treatment Promotes Remote Hippocampal Plasticity after Experimental Cortical Stroke.

Int J Mol Sci 2020 Jun 26;21(12). Epub 2020 Jun 26.

School of Biomedical Sciences and Pharmacy and the Priority Research Centre for Stroke and Brain Injury, The University of Newcastle, University Dr, Callaghan, NSW 2308, Australia.

Cognitive impairment is common after stroke, and disturbances in hippocampal function are often involved, even in remote non-hippocampal injuries. In terms of hippocampal function, growth hormone (GH) is known to affects plasticity and cognition. We aimed to investigate whether GH treatment after an experimental cortical stroke could enhance remote hippocampal plasticity and the hippocampal-dependent visual discrimination task. Read More

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http://dx.doi.org/10.3390/ijms21124563DOI Listing

Access of Stroke Patients' to Optimal Healthcare Technology in Greece: Messages to Policy Makers.

Stud Health Technol Inform 2020 Jun;272:421-424

Hellenic Stroke Organization, Greece.

The aim of this study was to evaluate accessibility of stroke patients to optimal healthcare technology in Greece. Methods: The study population consisted of 313 first ever stroke patients derived from the "Stroke Units Necessity for Patients, SUN4P" registry. Descriptive statistics were used, to present patients' characteristics and resources utilization Results: The vast majority of patients (91. Read More

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http://dx.doi.org/10.3233/SHTI200585DOI Listing

Trans-cranial Doppler predicts early neurologic deterioration in anterior circulation ischemic stroke after successful endovascular treatment.

Chin Med J (Engl) 2020 Jun 26. Epub 2020 Jun 26.

Department of Neurology, Liangxiang Hospital of Beijing Fangshan District, Beijing 102246, China.

Background: Early neurologic deterioration (END) may occur in patients with anterior circulation ischemic stroke (ACIS) after receiving endovascular treatment (EVT). Hemodynamic insufficiency, re-occlusion, and post-re-canalization hyper-perfusion are likely to play a critical role in END. We hypothesized that hemodynamic changes can predict END in patients with ACIS post-successful EVT using trans-cranial Doppler (TCD). Read More

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http://dx.doi.org/10.1097/CM9.0000000000000881DOI Listing

Diagnosis of Neural Deterioration in Patients with Cerebral Infarction Combined with Non-valvular Atrial Fibrillation under Magnetic Resonance Imaging and Exploration of the Prognostic Infection Factors.

Neurosci Lett 2020 Jun 27:135213. Epub 2020 Jun 27.

Department of Emergency, Geriatric Hospital of Nanjing Medical University, Nanjing City, 210024, China.

To study the prognosis and risk factors of neural deterioration in patients with acute cerebral infarction combined with nonvalvular atrial fibrillation (NVAF), a computer platform was constructed and relevant clinical analysis was conducted, and the basic framework of computer cerebrovascular disease database was established. According to the clinical data of 300 patients with cerebral infarction with NVAF, test results, and imaging data, the anticoagulation treatment, PT-INR monitoring, and the occurrence of healthcare-associated infection recorded in the computer database were tracked, and prognostic factors and infective factors were investigated and recorded. The results showed that among the 70 patients receiving warfarin anticoagulation therapy, there were significant differences in proportion of admission NIHSS score and massive infarction (P < 0. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135213DOI Listing

Prognostic value of chemokines in patients with newly diagnosed atrial fibrillation.

Int J Cardiol 2020 Jun 27. Epub 2020 Jun 27.

Department of Epidemiology, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing 400038, People's Republic of China; Evidence-based Medicine and Clinical Epidemiology Center, Army Medical University (Third Military Medical University), Chongqing 400038, People's Republic of China. Electronic address:

Background: Chemokines play an important role in inflammation and atherosclerosis. However, little is known about the relationship between chemokines and the prognosis of atrial fibrillation (AF). This "real-world" cohort study was designed to observe the prognostic value of plasma CC motif chemokine ligand (CCL) 18, CCL23, CCL28, CXC motif chemokine ligand (CXCL) 14, CXCL16 in newly diagnosed AF patients. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.06.030DOI Listing

Large animals as models of atrial fibrillation.

Adv Clin Exp Med 2020 Jun;29(6):757-767

Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Poland.

In clinical practice, atrial fibrillation (AF) is the most common cardiac arrhythmia in humans and it may lead to numerous complications, including central nervous system embolism. The electrical activity of the heart in AF is rapid and chaotic, while the atrioventricular conduction leads to irregular ventricular contraction. Consequently, the stroke volume is reduced, which may lead to symptoms of heart failure. Read More

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http://dx.doi.org/10.17219/acem/122130DOI Listing

Reasons for readmission after hospital discharge in patients with chronic diseases-Information from an international dataset.

PLoS One 2020 30;15(6):e0233457. Epub 2020 Jun 30.

Dr Foster Telstra Health, London, United Kingdom.

Background: Chronic diseases are increasingly prevalent in Western countries. Once hospitalised, the chance for another hospitalisation increases sharply with large impact on well-being of patients and costs. The pattern of readmissions is very complex, but poorly understood for multiple chronic diseases. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233457PLOS

Association of Nonsteroidal Anti-inflammatory Drug Use With Survival in Patients With Squamous Cell Carcinoma of the Head and Neck Treated With Chemoradiation Therapy.

JAMA Netw Open 2020 Jun 1;3(6):e207199. Epub 2020 Jun 1.

Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.

Importance: Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, are commonly prescribed medications with anti-inflammatory and antiplatelet properties used long term to decrease the risk of cardiovascular events. A recent study showed that aspirin was associated with improved survival in patients with head and neck squamous cell carcinoma (HNSCC) who were treated with surgery.

Objective: To examine whether use of NSAIDs during definitive chemoradiation therapy (CRT) was associated with improved outcomes in patients with HNSCC. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.7199DOI Listing

miR-183-5p alleviates early injury after intracerebral hemorrhage by inhibiting heme oxygenase-1 expression.

Aging (Albany NY) 2020 Jun 29;12. Epub 2020 Jun 29.

Department of Pathology, First Clinical Hospital, Harbin Medical University, Harbin 150001, China.

Differences in microRNA (miRNA) expression after intracerebral hemorrhage (ICH) have been reported in human and animal models, and miRNAs are being investigated as a new treatment for inflammation and oxidative stress after ICH. In this study, we found that microRNA-183-5p expression was decreased in the mouse brain after ICH. To investigate the effect of miRNA-183-5p on injury and repair of brain tissue after ICH, saline, miRNA-183-5p agomir, or miRNA-183-5p antagomir were injected into the lateral ventricles of 8-week-old mice with collagenase-induced ICH. Read More

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http://dx.doi.org/10.18632/aging.103343DOI Listing

Sleep problems worsen health-related quality of life and participation during the first 12 months of stroke rehabilitation.

Clin Rehabil 2020 Jun 30:269215520935940. Epub 2020 Jun 30.

SUNY Upstate Medical University, Syracuse, NY, USA.

Objective: Evaluate the impact of self-reported sleep problems on post-stroke recovery.

Design: Cross-sectional secondary analysis of longitudinal data from the Locomotor Experience Applied Post-Stroke (LEAPS) rehabilitation and recovery study (phase-III single-blind randomized controlled clinical trial). Group medians were compared for three sleep problem groups across three time points. Read More

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http://dx.doi.org/10.1177/0269215520935940DOI Listing

Atrial Fibrillation and Mitral Regurgitation: Clinical Performance of Direct Oral Anticoagulants in a Real-World Setting.

J Cardiovasc Pharmacol Ther 2020 Jun 30:1074248420935263. Epub 2020 Jun 30.

Division of Cardiology, Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli," Monaldi Hospital, Naples, Italy.

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia and is frequently present in patients with mitral regurgitation (MR). Currently, there is a lack of real-world evidence specifically addressing the clinical performance of direct oral anticoagulants (DOACs) in patients with AF and concomitant MR. Therefore, the aim of the present study was to assess the efficacy and safety profile of DOACs therapy in patients with AF and MR. Read More

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http://dx.doi.org/10.1177/1074248420935263DOI Listing

Benefit-Risk Profile of DAPT Continuation Beyond 1 Year after PCI in Patients with High Thrombotic Risk Features as Endorsed by 2018 ESC/EACTS Myocardial Revascularization Guideline.

Cardiovasc Drugs Ther 2020 Jun 29. Epub 2020 Jun 29.

Department of Cardiology, Coronary Heart Disease Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.

Purpose: The ischemic/bleeding trade-off of continuing dual antiplatelet therapy (DAPT) beyond 1 year after PCI for patients with high thrombotic risk (HTR) as endorsed by 2018 ESC/EACTS myocardial revascularization guidelines remain unknown.

Methods: Patients undergoing coronary stenting between January 2013 and December 2013 from the prospective Fuwai registry were defined as HTR if they met at least 1 ESC/EACTS guideline-endorsed HTR criteria. A total of 4578 patients who were at HTR and were events free at 1 year after the index procedure were evaluated. Read More

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http://dx.doi.org/10.1007/s10557-020-07030-9DOI Listing
June 2020
3.189 Impact Factor

Frequency of Human Immunodeficiency Virus in Patients Admitted with Acute Stroke.

Cureus 2020 May 26;12(5):e8296. Epub 2020 May 26.

Neurology, University Hospital Cleveland Medical Center, Cleveland, USA.

Introduction Stroke is a leading cause of chronic disability and death in both developing and developed countries. A significant proportion of stroke patients are human immunodeficiency virus (HIV) positive. About half of the HIV patients experience some sort of neurological deficit in their lifetimes. Read More

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http://dx.doi.org/10.7759/cureus.8296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317133PMC

Endovascular Treatment of Giant Intracranial Aneurysms.

Cureus 2020 May 26;12(5):e8290. Epub 2020 May 26.

Radiology, Miami Cardiac & Vascular Institute/Miami Neuroscience Institute, Miami, USA.

Objective Giant intracranial aneurysms (GIAs) are associated with a high risk of rupture and have a high mortality rate when they rupture (65-100%). The traditional microsurgical approach to secure these lesions is challenging, and as such endovascular embolization has been increasingly selected as a treatment option. Methods We performed a retrospective analysis of consecutive patients with ruptured and unruptured GIAs at three medical centers from October 2008 to April 2016. Read More

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http://dx.doi.org/10.7759/cureus.8290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317134PMC

Transradial middle meningeal artery embolization for chronic subdural hematoma using Onyx: case series.

J Neurointerv Surg 2020 Jun 29. Epub 2020 Jun 29.

Neurosurgery, Gates Vascular Institute, Buffalo, New York, USA

Background: Middle meningeal artery (MMA) embolization is an emerging therapy for the resolution of subacute or chronic subdural hematoma (CSDH). CSDH patients are often elderly and have several comorbidities. We evaluated our experience with transradial access (TRA) for MMA embolization using predominantly Onyx under conscious sedation. Read More

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http://dx.doi.org/10.1136/neurintsurg-2020-016185DOI Listing

Association of pre-stroke metformin use, stroke severity, and thrombolysis outcome.

Neurology 2020 Jun 29. Epub 2020 Jun 29.

Department of Neurology, University Hospital Zurich, Switzerland (LPW, RW, ARL, SW).

Objective: To evaluate whether pretreatment with metformin (MET) is associated with less stroke severity and better outcome after intravenous thrombolysis (IVT), we analyzed a cohort of 1919 stroke patients with type-2 diabetes in a multicenter exploratory analysis.

Methods: Data from patients with diabetes affected by ischemic stroke treated with IVT were collected within the European Thrombolysis in Ischemic Stroke Patients (TRISP) collaboration. We applied propensity score matching (PSM) to obtain balanced baseline characteristics of patients treated with and without MET. Read More

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http://dx.doi.org/10.1212/WNL.0000000000009951DOI Listing

Comparison of dual antiplatelet therapies after coronary endarterectomy combined with coronary artery bypass grafting: a cohort study.

J Cardiothorac Surg 2020 Jun 29;15(1):155. Epub 2020 Jun 29.

Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Road No. 167, Xicheng District, Beijing, 100037, China.

Background: Coronary endarterectomy (CE) combined with coronary artery bypass grafting (CABG) can be the only option for complete revascularization in some patients with diffuse coronary artery disease. Unfortunately, CE can cause the lack of endothelium, resulting in increased risk of thrombotic events. Therefore, antithrombotic therapy is very important after surgery. Read More

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http://dx.doi.org/10.1186/s13019-020-01205-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325049PMC

Improved stability of long-duration sitting in spatial neglect after a single session of prism adaptation.

Neurocase 2020 Jun 29:1-10. Epub 2020 Jun 29.

Department of Neurology, Emory School of Medicine , Atlanta, GA, USA.

Spatial neglect after right brain stroke affects balance, and improvements in sitting balance after prism adaptation have been demonstrated using short-duration center of pressure (CoP) data. We present long-duration (5 min) CoP and trunk muscles electromyography recordings of a 61-year-old man with left-sided spatial neglect, before and after a single session of prism adaptation. His CoP-derived measures showed improved balance and postural stability in both the anterior-posterior and medial-lateral directions after prism adaptation. Read More

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http://dx.doi.org/10.1080/13554794.2020.1786134DOI Listing

FT-NIRS Coupled with PLS Regression as a Complement to HPLC Routine Analysis of Caffeine in Tea Samples.

Foods 2020 Jun 24;9(6). Epub 2020 Jun 24.

Department of Biological Sciences & Chemistry, College of Arts and Sciences, University of Nizwa, P.O. Box 33, Nizwa 611, Oman.

Daily consumption of caffeine in coffee, tea, chocolate, cocoa, and soft drinks has gained wide and plentiful public and scientific attention over the past few decades. The concentration of caffeine in vivo is a crucial indicator of some disorders-for example, kidney malfunction, heart disease, increase of blood pressure and alertness-and can cause some severe diseases including type 2 diabetes mellitus (DM), stroke risk, liver disease, and some cancers. In the present study, near-infrared spectroscopy (NIRS) coupled with partial least-squares regression (PLSR) was proposed as an alternative method for the quantification of caffeine in 25 commercially available tea samples consumed in Oman. Read More

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http://dx.doi.org/10.3390/foods9060827DOI Listing