7,736 results match your criteria Medical Science Monitor[Journal]


Transcriptional Regulation of Early Growth Response Gene-1 (EGR1) is Associated with Progression of Nonalcoholic Fatty Liver Disease (NAFLD) in Patients with Insulin Resistance.

Med Sci Monit 2019 Apr 23;25:2293-3004. Epub 2019 Apr 23.

Department of Minimally Invasive Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China (mainland).

BACKGROUND The occurrence of nonalcoholic fatty liver disease (NAFLD) is closely related to type 2 diabetes, especially in patients with insulin resistance. The purpose of this research was to elucidate the major genes and transcriptional regulation of insulin resistance in the progression of NAFLD. MATERIAL AND METHODS We downloaded the gene expression matrix of GSE89632 from Gene Expression Omnibus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.914044DOI Listing

Long Non-Coding RNA ZFAS1 as a Novel Potential Biomarker for Predicting the Prognosis of Thyroid Cancer.

Med Sci Monit 2019 Apr 23;25:2984-2992. Epub 2019 Apr 23.

Department of Thyroid Vascular Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, Hubei, China (mainland).

BACKGROUND Thyroid cancer is a type of endocrine cancers with rapidly increased incidence. Recent studies have indicated long non-coding RNAs (lncRNAs) played crucial roles in thyroid cancer tumorigenesis and progression. However, the roles of most lncRNAs in thyroid cancer were still unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.912921DOI Listing

Effect of Cyclocarya Paliurus on Hypoglycemic Effect in Type 2 Diabetic Mice.

Med Sci Monit 2019 Apr 23;25:2976-2983. Epub 2019 Apr 23.

College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, Guangxi, China (mainland).

BACKGROUND The aim of this study was to assess the hypoglycemic effect of Cyclocarya paliurus extract (CPE) on diabetes mellitus (DM) mice. MATERIAL AND METHODS A DM mouse model was established to test FBG, TC, and TG. The DM mice were divided into 3 groups: a DM group, a DM+CPE (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.913368DOI Listing

Longevity-Associated Forkhead Box O3 (FOXO3) Single Nucleotide Polymorphisms are Associated with Type 2 Diabetes Mellitus in Chinese Elderly Women.

Med Sci Monit 2019 Apr 22;25:2966-2975. Epub 2019 Apr 22.

Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan Univesity, Shanghai, China (mainland).

BACKGROUND This study aimed to investigate the association of single nucleotide polymorphisms (SNPs) of Forkhead box O3 (FOXO3) gene with type 2 diabetes mellitus (T2D). MATERIAL AND METHODS A total of 843 elderly residents from east China were enrolled in this study, which included 426 patients with type 2 diabetes and 417 controls. Four SNPs were analyzed by qPCR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.913788DOI Listing

Genomic Alterations of Renal Cell Carcinoma and Clinical Implications in the Chinese Population.

Med Sci Monit 2019 Apr 22;25:2959-2965. Epub 2019 Apr 22.

Department of Urology, Peking University Third Hospital, Beijing, China (mainland).

BACKGROUND The aim of this study was to investigate the genomic alterations of renal cell carcinoma (RCC) in Chinese patients and to evaluate the correlations between significantly mutated genes and tumor mutation burden (TMB) levels in RCC. MATERIAL AND METHODS Two batch of specimens were collected from patients with RCC. Cohort 1 enrolled 17 RCC patients. Read More

View Article

Download full-text PDF

Source
https://www.medscimonit.com/abstract/index/idArt/914493
Publisher Site
http://dx.doi.org/10.12659/MSM.914493DOI Listing
April 2019
1 Read

Intralesional Injection of Botulinum Toxin Type A Compared with Intralesional Injection of Corticosteroid for the Treatment of Hypertrophic Scar and Keloid: A Systematic Review and Meta-Analysis.

Med Sci Monit 2019 Apr 22;25:2950-2958. Epub 2019 Apr 22.

Department of Plastic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland).

BACKGROUND The optimal treatment for hypertrophic scar and keloid remains controversial. Therefore, the aim of this systematic review and meta-analysis was to compare the effectiveness of intralesional injection of botulinum toxin type A compared with placebo and intralesional injection of corticosteroid compared with placebo in patients with hypertrophic scar and keloid. MATERIAL AND METHODS Six databases were searched using Medical Subject Headings (MeSH) keywords and included Web of Science, PubMed, EMBASE, the Cochrane Library, WanFang, and CNKI from their inception to March 1 2019, without language restriction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.916305DOI Listing

Antiproliferative Effects of Matricine in Gemcitabine-Resistant Human Pancreatic Carcinoma Cells Are Mediated via Mitochondrial-Mediated Apoptosis, Inhibition of Cell Migration, Invasion Suppression, and Mammalian Target of Rapamycin (mTOR)-TOR/PI3K/AKT Signalling Pathway.

Med Sci Monit 2019 Apr 21;25:2943-2949. Epub 2019 Apr 21.

Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland).

BACKGROUND Pancreatic cancer is a major cause of mortality worldwide. Inefficient drugs, their adverse effects, and the development of drug resistance make it difficult to curb the growing incidence of pancreatic cancer. Against this backdrop, the development new drug regimens with no or negligible adverse effects is imperative. Read More

View Article

Download full-text PDF

Source
https://www.medscimonit.com/abstract/index/idArt/914244
Publisher Site
http://dx.doi.org/10.12659/MSM.914244DOI Listing
April 2019
2 Reads

Ferruginol Diterpenoid Selectively Inhibits Human Thyroid Cancer Growth by Inducing Mitochondrial Dependent Apoptosis, Endogenous Reactive Oxygen Species (ROS) Production, Mitochondrial Membrane Potential Loss and Suppression of Mitogen-Activated Protein Kinase (MAPK) and PI3K/AKT Signaling Pathways.

Med Sci Monit 2019 Apr 21;25:2935-2942. Epub 2019 Apr 21.

Department of Cardiothoracic Surgery, Qingyuan People's Hospital (The Sixth Affiliated Hospital of Guangzhou Medical University), Qingyuan, Guangdong, China (mainland).

BACKGROUND Thyroid cancer causes considerable mortality and morbidity across the globe. Owing to the unavailability of biomarkers and the adverse effects of existing drugs, there is an urgent need to develop efficient chemotherapy for the treatment of thyroid cancers. Plants have served as exceptional source of drugs for the treatment of lethal diseases. Read More

View Article

Download full-text PDF

Source
https://www.medscimonit.com/abstract/index/idArt/914348
Publisher Site
http://dx.doi.org/10.12659/MSM.914348DOI Listing
April 2019
2 Reads

Treatment of Type II Collagen-Induced Rat Rheumatoid Arthritis Model by Interleukin 10 (IL10)-Mesenchymal Stem Cells (BMSCs).

Med Sci Monit 2019 Apr 21;25:2923-2934. Epub 2019 Apr 21.

Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).

BACKGROUND Rheumatoid arthritis model (CIA) rats were treated by tail vein injection of IL-10-modified bone marrow mesenchymal stem cells (BMSCs) to investigate its feasibility and intrinsic molecular mechanism. MATERIAL AND METHODS The CIA rat model was established by induction type II collagen, and IL-10-modified BMSCs was established by transfecting BMSCs with adenovirus. IL-10-modified BMSCs were used to treat the CIA rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.911184DOI Listing
April 2019
1 Read

Femoral Artery Sclerosis Evaluation by Tissue Doppler in Patients with Hypertension.

Med Sci Monit 2019 Apr 20;25:2917-2922. Epub 2019 Apr 20.

Department of Ultrasonography, Tianjin Union Medical Center (Tianjin People's Hospital), Tianjin, China (mainland).

BACKGROUND The aim of this study was to evaluate the early femoral sclerosis in hypertensive patients by using tissue Doppler imaging (TDI). MATERIAL AND METHODS One hundred patients with hypertension were recruited and divided into group A (femoral artery intima-media thicknesses (IMT) ≥1.0 mm) and group B (femoral artery IMT <1. Read More

View Article

Download full-text PDF

Source
https://www.medscimonit.com/abstract/index/idArt/913271
Publisher Site
http://dx.doi.org/10.12659/MSM.913271DOI Listing
April 2019
1 Read

The Clinical Effectiveness of Calcium Hydroxide in Root Canal Disinfection of Primary Teeth: A Meta-Analysis.

Med Sci Monit 2019 Apr 20;25:2908-2916. Epub 2019 Apr 20.

Department of Pediatric Dentistry, Hospital of Stomatology Hebei Medical University, Shijiazhuang, Hebei, China (mainland).

BACKGROUND The aim of this research was to systematically analyze the effectiveness of calcium hydroxide compared to formocresol (FC) and camphor phenol (CP) in root canal disinfection of primary teeth. MATERIAL AND METHODS The meta-analysis was based on the participants, interventions, control, outcome (PICO) study design principle and 16 randomized-controlled clinical trials published from January 2000 to August 2018. The data heterogeneity of each study was assessed by the Q-test. Read More

View Article

Download full-text PDF

Source
https://www.medscimonit.com/abstract/index/idArt/913256
Publisher Site
http://dx.doi.org/10.12659/MSM.913256DOI Listing
April 2019
1 Read

Integrative Analysis of Long Noncoding RNA (lncRNA), microRNA (miRNA) and mRNA Expression and Construction of a Competing Endogenous RNA (ceRNA) Network in Metastatic Melanoma.

Med Sci Monit 2019 Apr 20;25:2896-2907. Epub 2019 Apr 20.

Department of Dermatology, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, Shandong, China (mainland).

Worldwide, metastatic melanoma of the skin has an aggressive course with high morbidity and mortality. Therefore, an increased understanding of the pathogenesis of metastatic melanoma has gained increasing attention, including the role of epigenetic modification and competing endogenous RNA (ceRNA). This study aimed to used bioinformatics data to undertake an integrative analysis of long noncoding RNA (lncRNA), microRNA (miRNA) and mRNA expression to construct a ceRNA network in metastatic melanoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.913881DOI Listing
April 2019
4 Reads

Effects of Sleep Deprivation (SD) on Rats via ERK1/2 Signaling Pathway.

Med Sci Monit 2019 Apr 19;25:2886-2895. Epub 2019 Apr 19.

Department of Neurology, Yantai Yuhuangding Hospital, Yantai, Shandong, China (mainland).

BACKGROUND Sleep deprivation (SD) is common in humans, and sleep loss has a significant influence on health and produces related diseases. Orexin-A has been demonstrated to play a role in physiological processes, including feeding, sleep/wake cycle, and energy metabolism. The aim of this study was to investigate the effect of SD on rats and to define the underlying mechanism. Read More

View Article

Download full-text PDF

Source
https://www.medscimonit.com/abstract/index/idArt/913839
Publisher Site
http://dx.doi.org/10.12659/MSM.913839DOI Listing
April 2019
1 Read

Cost-Effectiveness Analysis of Integrated Care in Management of Advanced Chronic Obstructive Pulmonary Disease (COPD).

Med Sci Monit 2019 Apr 19;25:2879-2885. Epub 2019 Apr 19.

Department of Allergology, Medical University of Gdańsk, Gdańsk, Poland.

BACKGROUND Chronic obstructive pulmonary disease (COPD) is a common disease that occurs all over the world. Models of care, initially accessed from the clinical point of view, must also be evaluated in terms of their economic effectiveness, as health care systems are limited. The Integrated Care Model (ICM) is a procedure dedicated to patients suffering from advanced COPD that offers home-oriented support from a multidisciplinary team. Read More

View Article

Download full-text PDF

Source
https://www.medscimonit.com/abstract/index/idArt/913358
Publisher Site
http://dx.doi.org/10.12659/MSM.913358DOI Listing
April 2019
2 Reads

Is Atrial Natriuretic Peptide (ANP) and Natriuretic Peptide Receptor-A (NPR-A) Expression in Human Placenta and Decidua Normal?

Med Sci Monit 2019 Apr 19;25:2868-2878. Epub 2019 Apr 19.

Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland).

BACKGROUND Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates blood pressure and the salt-water balance in the blood. It acts through natriuretic peptide receptors (NPR), and the major biologically active ANP receptor is natriuretic peptide receptor-A (NPR-A). Aberrant forms of ANP and its receptors have been reported in patients with preeclampsia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.915449DOI Listing

Combining Spinal-Epidural Anesthesia versus Single-Shot Spinal Anesthesia for Cesarean Delivery: A Meta-Analysis of 5 Randomized Controlled Trials.

Med Sci Monit 2019 Apr 18;25:2859-2867. Epub 2019 Apr 18.

Department of International Medical, China-Japan Friendship Hospital, Beijing, China (mainland).

BACKGROUND This study compared combined spinal-epidural anesthesia (CSEA) and single-shot spinal anesthesia (SSSA) by performing a meta-analysis. MATERIAL AND METHODS An electronic search of relevant studies was done through 2017. Primary endpoints included duration of surgery, and time for (1) sensory recovery to thoracic vertebra (T10), (2) maximal sensory, (3) motor blockade, and (4) motor recovery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.913744DOI Listing
April 2019
1 Read

Anthecotulide Sesquiterpene Lactone Exhibits Selective Anticancer Effects in Human Malignant Melanoma Cells by Activating Apoptotic and Autophagic Pathways, S-Phase Cell Cycle Arrest, Caspase Activation, and Inhibition of NF-κB Signalling Pathway.

Med Sci Monit 2019 Apr 18;25:2852-2858. Epub 2019 Apr 18.

Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China (mainland).

BACKGROUND We examined the anticancer potential of anthecotulide against SK-MEL-24 malignant melanoma cells. The apoptotic and autophagic effects of anthecotulide were also investigated. MATERIAL AND METHODS The cell viability of SK-MEL-24 human malignant melanoma cells was evaluated by WST-1 assay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.913771DOI Listing

Long Non-Coding RNA BANCR Is Overexpressed in Patients with Diabetic Retinopathy and Promotes Apoptosis of Retinal Pigment Epithelial Cells.

Med Sci Monit 2019 Apr 18;25:2845-2851. Epub 2019 Apr 18.

Department of Ophthalmology, The First Hospital of Shijiazhuang, Shijiazhuang, Hebei, China (mainland).

BACKGROUND lncRNA BANCR participates in the pathogenesis of various types of human diseases; however, its involvement in diabetic retinopathy is unknown. MATERIAL AND METHODS In this study, the expression of lncRNA BANCR in plasma of patients with diabetic retinopathy, diabetic patients without complications, and healthy controls was analyzed by qRT-PCR. The accuracy plasma BANCR in diagnosing diabetic retinopathy was analyzed by ROC curve analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.913359DOI Listing

Gexia-Zhuyu Decoction Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in Mice Partly via Liver Angiogenesis Mediated by Myeloid Cells.

Med Sci Monit 2019 Apr 17;25:2835-2844. Epub 2019 Apr 17.

Department of General Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China (mainland).

BACKGROUND This study aims to demonstrate the underlying correlation between the resolution of liver fibrosis induced by Gexia-Zhuyu decoction (GZD) treatment and myeloid cell-mediated angiogenesis. MATERIAL AND METHODS A liver fibrosis mouse model induced by carbon tetrachloride (CCl4) intervention was employed in this study. Dynamics of blood liver function parameters were followed. Read More

View Article

Download full-text PDF

Source
https://www.medscimonit.com/abstract/index/idArt/913481
Publisher Site
http://dx.doi.org/10.12659/MSM.913481DOI Listing
April 2019
2 Reads

A Preliminary Study of Microbiota Diversity in Saliva and Bronchoalveolar Lavage Fluid from Patients with Primary Bronchogenic Carcinoma.

Med Sci Monit 2019 Apr 17;25:2819-2834. Epub 2019 Apr 17.

Pulmonary and Critical Care Medicine Ward, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China (mainland).

BACKGROUND The present study aimed to evaluate the difference in microbiota diversity in the oral cavity and fluid bronchoalveolar lavage (BALF) of patients with lung cancer. MATERIAL AND METHODS Buccal (saliva) and lower respiratory tract BALF samples were collected from 51 patients with primary bronchogenic carcinoma and 15 healthy controls, and bacterial genomic DNA was extracted. High-throughput 16S rDNA amplicon sequencing was performed, and microbial diversity, composition, and functions of microbiota were analyzed by bioinformatics methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.915332DOI Listing
April 2019
3 Reads

The Effect of Prognostic Factors and Adjuvant Radiotherapy on Survival in Patients with High-Grade Early-Stage Endometrial Cancer: A Retrospective Clinical Study.

Med Sci Monit 2019 Apr 17;25:2811-2818. Epub 2019 Apr 17.

Gynecology and Obstetrics Clinic, Adana Seyhan State Hospital, Adana, Turkey.

BACKGROUND This retrospective clinical study aimed to investigate the effect of prognostic factors and adjuvant radiotherapy in patients with high-grade early-stage endometrial cancer on overall survival (OS) and disease-free survival (DFS). MATERIAL AND METHODS The medical records of patients diagnosed with high-grade, early stage (I or II) endometrial adenocarcinoma who had received adjuvant radiotherapy after surgery were reviewed. RESULTS Seventy-nine patients included 39 patients (49. Read More

View Article

Download full-text PDF

Source
https://www.medscimonit.com/abstract/index/idArt/913740
Publisher Site
http://dx.doi.org/10.12659/MSM.913740DOI Listing
April 2019
3 Reads

3D Computed Tomography Mapping of Thoracolumbar Vertebrae Fractures.

Med Sci Monit 2019 Apr 16;25:2802-2810. Epub 2019 Apr 16.

Department of Orthopedics, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (mainland).

BACKGROUND Fractures of the thoracolumbar (TL) spine represent 90% of all spinal fractures, followed by cervical and lumbar spine fractures. This study aimed to create fracture maps of the traumatic thoracolumbar (TL) fracture vertebral body (T12-L2) through the use of CT mapping as a big data visualization method to reveal recurrent patterns and characteristics of traumatic TL fractures. MATERIAL AND METHODS A consecutive series of 174 fractured vertebrae (T12-L2) was used to create three-dimensional (3D) reconstruction images, which were superimposed and oriented to fit a model vertebral template by aligning specific bio-landmarks and reducing reconstructed fracture fragments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.915916DOI Listing
April 2019
1 Read

Study on the Significance of Folate Receptor-Mediated Staining Solution (FRD) Staining in Screening High Grade Cervical Lesions.

Med Sci Monit 2019 Apr 16;25:2792-2801. Epub 2019 Apr 16.

Department of Gynecology and Obstetrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China (mainland).

BACKGROUND The aim of this study was to investigate the significance of folate receptor-mediated staining solution (FRD) in examination of cervical lesions during gynecological examination. MATERIAL AND METHODS A total of 404 patients participated in this study. FRD staining was applied to screen high grade cervical lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.911402DOI Listing
April 2019
1 Read

Identification of Altered Circular RNA Expression in Serum Exosomes from Patients with Papillary Thyroid Carcinoma by High-Throughput Sequencing.

Med Sci Monit 2019 Apr 16;25:2785-2791. Epub 2019 Apr 16.

Graduate School of Medicine, Nanchang University, Nanchang, Jiangxi, China (mainland).

BACKGROUND This study aimed to identify altered exosome circular RNA (circRNA) in the serum of patients with papillary thyroid carcinoma using high-throughput sequencing. MATERIAL AND METHODS Serum was collected from three patients with papillary thyroid carcinoma and three patients with a benign thyroid goiter. Exosomes were isolated using an exosome isolation kit and confirmed by transmission electron microscopy. Read More

View Article

Download full-text PDF

Source
https://www.medscimonit.com/abstract/index/idArt/915658
Publisher Site
http://dx.doi.org/10.12659/MSM.915658DOI Listing
April 2019
3 Reads

Avicularin Relieves Depressive-Like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice.

Med Sci Monit 2019 Apr 15;25:2777-2784. Epub 2019 Apr 15.

College of Medicine, Jiaxing University, Jiaxing, Zhejiang, China (mainland).

BACKGROUND Avicularin (AL, quercetin-3-alpha-l-arabinofuranoside), a glycoside of quercetin, has been reported to display diverse pharmacological properties. The present study aimed to investigate whether AL has an anti-depressant-like effect on a mouse model of depression induced by chronic unpredictable mild stress (CUMS). MATERIAL AND METHODS A mouse model of depression was established and treated with different concentrations of AL (1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.912401DOI Listing
April 2019
1 Read

Apigenin Alleviates Myocardial Reperfusion Injury in Rats by Downregulating miR-15b.

Med Sci Monit 2019 Apr 15;25:2764-2776. Epub 2019 Apr 15.

Department of Nursing, Medical College, Hebei University of Engineering, Handan, Hebei, China (mainland).

BACKGROUND We investigated whether apigenin could mitigate myocardial reperfusion injury in rats, and a possible mechanism was proposed. MATERIAL AND METHODS The I-R injury model was established in rats along with a sham group as control, and the expressions of microRNA-15b (miR-15b), JAK2, and p-JAK2 in the myocardia of the 2 groups were detected. Apoptosis and reactive oxygen species (ROS) were also detected. Read More

View Article

Download full-text PDF

Source
https://www.medscimonit.com/abstract/index/idArt/912014
Publisher Site
http://dx.doi.org/10.12659/MSM.912014DOI Listing
April 2019
2 Reads

Analysis of NKX2-5 in 439 Chinese Patients with Sporadic Atrial Septal Defect.

Med Sci Monit 2019 Apr 15;25:2756-2763. Epub 2019 Apr 15.

The First People's Hospital of Yunnan Province, Kunming, Yunnan, China (mainland).

BACKGROUND The NKX2 gene family is made up of core transcription factors that are involved in the morphogenesis of the vertebrate heart. NKx2-5 plays a pivotal role in mouse cardiogenesis, and mutations in NKx2-5 result in an abnormal structure and function of the heart, including atrial septal defect and cardiac electrophysiological abnormalities. MATERIAL AND METHODS To investigate the genetic variation of NKX2-5 in Chinese patients with sporadic atrial septal defect, we sequenced the full length of the NKX2-5 gene in the participants of the study. Read More

View Article

Download full-text PDF

Source
https://www.medscimonit.com/abstract/index/idArt/916052
Publisher Site
http://dx.doi.org/10.12659/MSM.916052DOI Listing
April 2019
3 Reads

lncRNA Colorectal Neoplasia Differentially Expressed (CRNDE) Promotes Proliferation and Inhibits Apoptosis in Non-Small Cell Lung Cancer Cells by Regulating the miR-641/CDK6 Axis.

Med Sci Monit 2019 Apr 14;25:2745-2755. Epub 2019 Apr 14.

Department Three of Respiratory Medicine, Shanxi Provincial Cancer Hospital, Taiyuan, Shanxi, China (mainland).

BACKGROUND The lncRNA Colorectal Neoplasia Differentially Expressed (CRNDE) gene has been reported as a potential oncogene in NSCLC. Nevertheless, the molecular mechanism of CRNDE in NSCLC progression remains largely unknown. MATERIAL AND METHODS qRT-PCR assay was performed to detect the expression levels of CRNDE, miR-641, and cyclin-dependent kinase 6 (CDK6) in NSCLC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.913420DOI Listing
April 2019
1 Read

The Treatment of Axillary Odor: A Network Meta-Analysis.

Med Sci Monit 2019 Apr 14;25:2735-2744. Epub 2019 Apr 14.

Department of Plastic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland).

BACKGROUND Axillary osmidrosis (AO) is common in plastic surgery. But there is no perfect way to treat AO. We systematically compared the efficacy of 10 AO treatments with network meta-analysis in order to provide reference for the clinical treatment of axillary odor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.913932DOI Listing

Transcatheter Thrombolysis with Percutaneous Transluminal Angioplasty Using a Trans-Brachial Approach to Treat Thrombosed Arteriovenous Fistulas.

Med Sci Monit 2019 Apr 13;25:2727-2734. Epub 2019 Apr 13.

Department of Diagnostic Radiology, City of Hope National Medical Center, Duarte, CA, USA.

BACKGROUND Arteriovenous fistulas (AVFs) are used to provide vascular access for hemodialysis in patients with end-stage renal failure. However, stenosis and thrombosis can compromise long-term AVF patency. The objective of this study was to evaluate catheter thrombolysis with percutaneous transluminal angioplasty (PTA), using a trans-brachial approach, for acutely thrombosed AVFs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.915755DOI Listing
April 2019
1 Read

The Overexpression of Sirtuin1 (SIRT1) Alleviated Lipopolysaccharide (LPS)-Induced Acute Kidney Injury (AKI) via Inhibiting the Activation of Nucleotide-Binding Oligomerization Domain-Like Receptors (NLR) Family Pyrin Domain Containing 3 (NLRP3) Inflammasome.

Med Sci Monit 2019 Apr 13;25:2718-2726. Epub 2019 Apr 13.

Department of Critical Care Medicine, Jining No. 1 People's Hospital, Jining, Shandong, China (mainland).

BACKGROUND Sepsis-induced acute kidney injury (AKI) is threatening the patients with sepsis, and nucleotide-binding oligomerization domain-like receptors (NLR) family pyrin domain containing 3 (NLRP3) inflammasome is considered to play a critical role in this complication of sepsis and might be regulated by sirtuin1 (SIRT1). Thus, we explored the roles of NLRP3 and SIRT1 in the lipopolysaccharide (LPS)-induced AKI in the HK-2 cell line. MATERIAL AND METHODS Cell viability was assessed by Cell Counting Kit-8 (CCK-8). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.913146DOI Listing

A Novel Rat Model of Patellofemoral Osteoarthritis Due to Patella Baja, or Low-Lying Patella.

Med Sci Monit 2019 Apr 13;25:2702-2717. Epub 2019 Apr 13.

Department of Orthopedic Surgery, Hebei Medical University, Shijiazhuang, Hebei, China (mainland).

BACKGROUND Patella baja, or patella infera, consists of a low-lying patella that results in a limited range of motion, joint pain, and crepitations. Patellofemoral joint osteoarthritis (PFJOA) is a subtype OA of the knee. This study aimed to develop a reproducible and reliable rat model of PFJOA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.915018DOI Listing

Role of Endothelial Nitric Oxide Synthase Polymorphisms in Atrial Fibrillation: A PRISMA-Compliant Meta-Analysis.

Med Sci Monit 2019 Apr 12;25:2687-2694. Epub 2019 Apr 12.

Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (mainland).

BACKGROUND Research interest in endothelial nitric oxide synthase(eNOS) polymorphisms and atrial fibrillation (AF) has grown in last recent years, but the results of individual studies are inconsistent due to their small sample sizes. MATERIAL AND METHODS We searched databases for eligible studies on eNOS and AF, extracted the relevant data, and rigorously screened them according to inclusion and exclusion criteria. Then, we evaluated the study quality according to the Newcastle-Ottawa scale score, and we pooled the odds ratios (ORs) and 95% confidence intervals (CIs) by using a random-effects model or fixed-effects model based on inter-study heterogeneity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.913528DOI Listing
April 2019
1 Read

A Biochemical Analysis of the Stapes.

Med Sci Monit 2019 Apr 12;25:2679-2686. Epub 2019 Apr 12.

Department of Otolaryngology, Jagiellonian University Collegium Medicum, Cracow, Poland.

BACKGROUND Otosclerosis is a primary disease of the bony labyrinth. In the course of otosclerosis, abnormal resorption and recalcification of the endochondral layer of the temporal bone is observed. The otosclerotic process most commonly develops in the anterior part of the oval window. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.913635DOI Listing
April 2019
1 Read

Depression and Insomnia Are Closely Associated with Thyroid Hormone Levels in Chronic Hepatitis B.

Med Sci Monit 2019 Apr 11;25:2672-2678. Epub 2019 Apr 11.

Department of Digestive Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland).

BACKGROUND Depression and insomnia in chronic hepatitis B (CHB) patients affect the quality of life, disease diagnosis, and mortality. CHB patients are more likely to have psychological disorders, but the underlying mechanisms have not been elucidated. This study investigated the incidence of depression in patients with CHB and sought to identify risk factors for depression and insomnia in these patients, focusing on changes in liver function and thyroid hormone levels. Read More

View Article

Download full-text PDF

Source
https://www.medscimonit.com/abstract/index/idArt/914444
Publisher Site
http://dx.doi.org/10.12659/MSM.914444DOI Listing
April 2019
4 Reads

Application of a Strontium-Loaded, Phase-Transited Lysozyme Coating to a Titanium Surface to Enhance Osteogenesis and Osteoimmunomodulation.

Med Sci Monit 2019 Apr 11;25:2658-2671. Epub 2019 Apr 11.

Tianjin Medical University School and Hospital of Stomatology, Tianjin, China (mainland).

BACKGROUND To fabricate strontium (Sr)-incorporated titanium (Ti) surfaces by a novel 1-step phase-transited lysozyme (PTL) treatment, and investigate the effects of the prepared samples on osteogenesis and osteoimmunoregulation. MATERIAL AND METHODS Five groups of titanium specimens were prepared, including Ti, PTL, PTL@10Sr (PTL coating with 10 mg/mL Sr), PTL@20Sr PTL coating with 20 mg/mL Sr), and PTL@50Sr (PTL coating with 50 mg/mL Sr) groups. Behaviors of bone marrow mesenchymal stem cells (BMSCs) such as initial attachment, spread, proliferation, and migration, on different surfaces were examined by immunofluorescence, MTS assay, and Transwell system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.914269DOI Listing
April 2019
1 Read

Long-Term Persistence with Newly-Initiated Warfarin or Non-VKA Oral Anticoagulant (NOAC) in Patients with Non-Valvular Atrial Fibrillation: Insights from the Prospective China-AF Registry.

Med Sci Monit 2019 Apr 11;25:2649-2657. Epub 2019 Apr 11.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, Beijing, China (mainland).

BACKGROUND Oral anticoagulants (OACs) such as warfarin and non-VKA oral anticoagulants (NOACs) have been recommended for patients with atrial fibrillation (AF) who are at risk for stroke. Whether NOACs have a higher persistence than warfarin is still unclear. This is especially true in China. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.915875DOI Listing
April 2019
3 Reads

Ultrasound-Targeted Microbubble Destruction (UTMD) Combined with Liposome Increases the Effectiveness of Suppressing Proliferation, Migration, Invasion, and Epithelial- Mesenchymal Transition (EMT) via Targeting Metadherin (MTDH) by ShRNA.

Med Sci Monit 2019 Apr 10;25:2640-2648. Epub 2019 Apr 10.

Department of Medical Imaging, Zhangqiu Maternal and Child Health Care Hospital, Jinan, Shandong, China (mainland).

BACKGROUND Reports show that ultrasound-targeted microbubble destruction (UTMD) is a promising method of gene therapy, and metadherin (MTDH) is related to the development of breast cancer. Thus, we investigated the role of MTDH in breast cancer and compared the effect of suppressing MTDH by shRNA using liposome, UTMD, or the combination of these 2 methods. MATERIAL AND METHODS Graphing of survival curves of MTDH was analyzed by bioinformatics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.912955DOI Listing

Serum Levels of Inflammatory Cytokines and Expression of BCL2 and BAX mRNA in Peripheral Blood Mononuclear Cells and in Patients with Chronic Heart Failure.

Med Sci Monit 2019 Apr 10;25:2633-2639. Epub 2019 Apr 10.

Department of Cardiology, Hebei Medical University, Shijiazhuang, Hebei, China (mainland).

BACKGROUND This study investigated the expression of the BCL2 and BAX mRNA, inflammatory cytokines, interleukin-1ß (IL-1ß), IL-6, and tumor necrosis factor-alpha (TNF-alpha), and cardiac function in patients with chronic heart failure (CHF). The New York Heart Association (NYHA) Functional Classification and measurement of the left ventricular ejection fraction (LVEF) evaluated cardiac function. MATERIAL AND METHODS Patients with CHF (n=60) due to coronary heart disease, hypertensive heart disease, and cardiomyopathy, and healthy controls (n=30) were studied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.912457DOI Listing

Mesenchymal Stem Cells Alleviate Acute Lung Injury and Inflammatory Responses Induced by Paraquat Poisoning.

Med Sci Monit 2019 Apr 10;25:2623-2632. Epub 2019 Apr 10.

Emergency Department, Shengjing Hospital Affiliated to China Medical University, Shenyang, Liaoning, China (mainland).

BACKGROUND Mesenchymal stem cells (MSCs) show anti-oxidative and anti-inflammatory effects that have prompted further research into their potential applications in treating paraquat (PQ) poisoning cases in emergency rooms. We assessed the protective effects, underlying mechanisms, and secondary inflammatory responses of MSCs on PQ-induced acute lung injury. MATERIAL AND METHODS Sprague-Dawley rats were injected intraperitoneally with PQ (20 µg per gram of body weight). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.915804DOI Listing
April 2019
1 Read

Construction and Analysis of lncRNA-Mediated ceRNA Network in Cervical Squamous Cell Carcinoma by Weighted Gene Co-Expression Network Analysis.

Med Sci Monit 2019 Apr 9;25:2609-2622. Epub 2019 Apr 9.

College of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong, China (mainland).

BACKGROUND More and more recent studies have clearly shown that long non-coding RNA (lncRNA) should be considered as a fundamental part of the ceRNA network, mainly because lncRNA can act as miRNA sponges to regulate the protein-coding gene expression. Nevertheless, it is still not clear how lncRNA-mediated ceRNAs function in cervical squamous cell carcinoma (CESC). Moreover, information about the ceRNA regulatory mechanism is also remarkably limited; thus, prediction of CESC prognosis using ceRNA-related information remains challenging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.913471DOI Listing
April 2019
2 Reads

The Signal Transducer and Activator of Transcription 5B (STAT5B) Gene Promotes Proliferation and Drug Resistance of Human Mantle Cell Lymphoma Cells by Activating the Akt Signaling Pathway.

Med Sci Monit 2019 Apr 9;25:2599-2608. Epub 2019 Apr 9.

Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer Hospital, Chongqing, China (mainland).

BACKGROUND Mantle cell lymphoma (MCL) is a high-grade B-cell lymphoma with poor prognosis. Fludarabine is used alone or in combination for relapsed and advanced-stage MCL. The expression of the signal transducer and activator of transcription 5B (STAT5B) gene is associated with tumorigenesis in solid tumors, but its role in MCL remains unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.914934DOI Listing
April 2019
1 Read

Prevalence and Risk Factors for Pressure Ulcers in Patients with Enterocutaneous Fistula: A Retrospective Single-Center Study in China.

Med Sci Monit 2019 Apr 9;25:2591-2598. Epub 2019 Apr 9.

Department of General Surgery, Jinling Hospital, Nanjing, Jiangsu, China (mainland).

BACKGROUND Prevalence and associated risk factors for pressure ulcers (PU) vary in different body areas and diseases. Few studies have focused on PU in patients with enterocutaneous fistula (ECF). The aim of the present study was to investigate the prevalence and risk factors for PU in patients with ECF. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.913261DOI Listing

Phytanoyl-CoA 2-Hydroxylase-Interacting Protein-Like Gene Is a Therapeutic Target Gene for Glioblastoma Multiforme.

Med Sci Monit 2019 Apr 9;25:2583-2590. Epub 2019 Apr 9.

YouJiang Medical University for Nationalities, Baise, Guangxi, China (mainland).

Glioblastoma multiforme (GBM) is the most common primary CNS cancer and has a poor prognosis. This study searched for significant genes and the mechanisms involved in GBM. We used the Gene Expression Omnibus (GEO) to test the WHO normal and IV glioma database, used R tool to identify the significant gene, and finally, combined these with The Cancer Genome Atlas (TCGA) to verify the significant genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.913895DOI Listing
April 2019
2 Reads

A Retrospective Study of 6-Month Reduction in Risk of Developing Cardiovascular Diseases and Type 2 Diabetes Mellitus in Severely Obese Patients Over 60 Years of Age Following Bariatric Surgery.

Med Sci Monit 2019 Apr 8;25:2577-2582. Epub 2019 Apr 8.

Department of General and Transplantation Surgery, Medical University of Warsaw, Warsaw, Poland.

BACKGROUND Controversy exists with regard to the effectiveness and reasons for bariatric procedures in patients older than 60 years. The goal of our study was to determine the reduction in risk of developing cardiovascular disease and type 2 diabetes mellitus after undergoing bariatric surgery in obese patients over age 60 at our institution. MATERIAL AND METHODS Patients with severe obesity (BMI >40 kg/m²) were retrospectively included in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.915937DOI Listing
April 2019
2 Reads

Allicin Improves Lung Injury Induced by Sepsis via Regulation of the Toll-Like Receptor 4 (TLR4)/Myeloid Differentiation Primary Response 88 (MYD88)/Nuclear Factor kappa B (NF-κB) Pathway.

Med Sci Monit 2019 Apr 8;25:2567-2576. Epub 2019 Apr 8.

Department of Respiratory Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China (mainland).

BACKGROUND The aim of this study was to assess the effects and mechanisms of allicin in a sepsis-induced lung injury in vivo study. MATERIAL AND METHODS The rats (n=54) were divided into 6 groups: Normal, DMSO, LPS, LPS+LD, LPS+MD, and LPS+HD groups. After being treated by different methods, we collected the lung tissues of different groups and evaluated the pathology by HE staining and positive apoptosis cells by TUNEL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.914114DOI Listing

Correlations of Changes in Brain Natriuretic Peptide (BNP) and Cardiac Troponin I (cTnI) with Levels of C-Reactive Protein (CRP) and TNF-α in Pediatric Patients with Sepsis.

Med Sci Monit 2019 Apr 8;25:2561-2566. Epub 2019 Apr 8.

Department of Pediatrics, The Second People's Hospital of Kashgar, Kashgar, Xinjiang, China (mainland).

BACKGROUND This study investigated the changes in plasma brain natriuretic peptide (BNP) and cardiac troponin I (cTnI) levels in pediatric patients with sepsis, and explored their relationships with serum inflammatory factors in pediatric patients. MATERIAL AND METHODS A total of 120 pediatric patients with sepsis admitted to and treated at our hospital from 2013 to 2017 were divided into 4 groups: a systemic inflammatory response syndrome (SIRS) group (n=28), a sepsis group (n=35), a severe sepsis group (n=27), and a septic shock group (n=30). Plasma BNP, cTnI, and creatine kinase-MB (CK-MB) levels in pediatric patients in the 4 groups were measured, and the correlations of BNP and cTnI with plasma inflammatory factors C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-alpha) were investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.912318DOI Listing
April 2019
2 Reads

The Mechanism of Bufalin-Induced Apoptosis of K562/A02.

Med Sci Monit 2019 Apr 7;25:2542-2552. Epub 2019 Apr 7.

Department of Hematology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland).

BACKGROUND In clinical practice, many patients become multidrug resistant during chemotherapy, resulting in reduced or no healing effect. Therefore, the present study focused on bufalin, which is extracted from a traditional Chinese medicine named Chan Su (Venenum bufonis). We assessed the effect of bufalin in reversing K562/A02 cell drug resistance and inducing apoptosis, and explored the possible mechanism by which bufalin induces K562/A02 cell apoptosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.915802DOI Listing
April 2019
1 Read

Uterine Peristalsis Before and After Ultrasound-Guided High-Intensify Focused Ultrasound (USgHIFU) Treatment for Symptomatic Uterine Fibroids.

Med Sci Monit 2019 Apr 7;25:2553-2560. Epub 2019 Apr 7.

Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China (mainland).

BACKGROUND This study investigated uterine peristalsis before and after ultrasound-guided high-intensify focused ultrasound (USgHIFU) treatment for symptomatic uterine fibroids by cine magnetic resonance imaging (cine MRI). MATERIAL AND METHODS A total of 30 patients with symptomatic uterine fibroids were treated by USgHIFU, who were subjected to cine MRI before and after USgHIFU treatment in the periovulatory phase. The images were analyzed for the existence, direction, and frequency of uterine peristalsis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.913392DOI Listing
April 2019
2 Reads

Long Non-Coding RNA AWPPH Promotes Postoperative Distant Recurrence in Resected Non-Small Cell Lung Cancer by Upregulating Transforming Growth Factor beta 1 (TGF-β1).

Med Sci Monit 2019 Apr 6;25:2535-2541. Epub 2019 Apr 6.

Department of General Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China (mainland).

BACKGROUND Postoperative recurrence of cancers is responsible for a large portion of deaths in cancer patients. Our study investigated the involvement of lncRNA AWPPH in recurrence of resected non-small cell lung cancer (NSCLC). MATERIAL AND METHODS A total of 128 patients were followed up for 3 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.912876DOI Listing
April 2019
5 Reads