7,564 results match your criteria Medical Science Monitor[Journal]


Implications of Classification of Os Trigonum: A Study Based on Computed Tomography Three-Dimensional Imaging.

Med Sci Monit 2019 Feb 22;25:1423-1428. Epub 2019 Feb 22.

Department of Orthopedic, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China (mainland).

BACKGROUND The os trigonum is an accessory bone that is not fully fused with the talus during secondary ossification, and is one of the risk factors of posterior malleolus impact syndrome. The purpose of this study was to classify the os trigonum and to guide the diagnosis and treatment of related clinical diseases. MATERIAL AND METHODS Ankle computed tomography (CT) scans of 586 Chinese patients between October 2014 and October 2018 were reviewed. Read More

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http://dx.doi.org/10.12659/MSM.914485DOI Listing
February 2019

Long Non-Coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes Proliferation and Metastasis of Osteosarcoma Cells by Targeting c-Met and SOX4 via miR-34a/c-5p and miR-449a/b.

Med Sci Monit 2019 Feb 22;25:1410-1422. Epub 2019 Feb 22.

Department of Hand Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (mainland).

BACKGROUND Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a functional long non-coding RNA involved in many biologic processes. The study was aimed to explore the functional roles of MALAT1 in osteosarcoma progression. MATERIAL AND METHODS A total of 76 osteosarcoma tissues and paired adjacent non-tumor tissues were collected from surgical resection. Read More

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https://www.medscimonit.com/abstract/index/idArt/912703
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http://dx.doi.org/10.12659/MSM.912703DOI Listing
February 2019
1 Read

The C-Reactive Protein/Albumin Ratio and Complete Blood Count Parameters as Indicators of Disease Activity in Patients with Takayasu Arteritis.

Med Sci Monit 2019 Feb 22;25:1401-1409. Epub 2019 Feb 22.

Department of Pediatrics, Division of Pediatric Hematology and Oncology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.

BACKGROUND This study aimed to evaluate the ratio of C-reactive protein (CRP) to albumin, inflammatory markers, and parameters from the complete blood count (CBC) in patients with Takayasu arteritis and the association with disease activity. MATERIAL AND METHODS A retrospective study included thirty-two patients with Takayasu arteritis and 32 healthy controls. Clinical and demographic characteristics of patients with Takayasu arteritis were recorded at baseline, before medication and on remission. Read More

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http://dx.doi.org/10.12659/MSM.912495DOI Listing
February 2019

Effect of 3D Printing Individualized Ankle-Foot Orthosis on Plantar Biomechanics and Pain in Patients with Plantar Fasciitis: A Randomized Controlled Trial.

Med Sci Monit 2019 Feb 21;25:1392-1400. Epub 2019 Feb 21.

Department of Pain, The Second Hospital of Jilin University, Changchun, Jilin, China (mainland).

BACKGROUND Traditional ankle-foot orthoses (AFOs) are not effective in treating plantar fasciitis, while customized 3-dimensional (3D) printed ankle-foot orthoses are effective in treating many ankle-foot diseases. This study investigated the effects of customized 3D printed AFOs on biomechanics and comfort of the plantar foot in plantar fasciitis. MATERIAL AND METHODS Sixty patients with bilateral plantar fasciitis aged 31-60 years participated in this study. Read More

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http://dx.doi.org/10.12659/MSM.915045DOI Listing
February 2019

To Explore the Protective Mechanism of PTEN-Induced Kinase 1 (PINK1)/Parkin Mitophagy-Mediated Extract of Periplaneta Americana on Lipopolysaccharide-Induced Cardiomyocyte Injury.

Med Sci Monit 2019 Feb 21;25:1383-1391. Epub 2019 Feb 21.

Department of Geriatrics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China (mainland).

BACKGROUND Sepsis is defined as a systemic inflammatory response syndrome caused by an infection (suspicious or confirmed). Its essence is inflammatory mediators and cytokines mediated by host immune response. The present study aimed to investigate the role of Periplaneta americana extracts (XML) on PTEN-induced kinase 1 (PINK1)/Parkin mediated mitophagy in cardiomyocyte injury by sepsis. Read More

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http://dx.doi.org/10.12659/MSM.912980DOI Listing
February 2019

Autophagy Induced by Oxygen-Glucose Deprivation Mediates the Injury to the Neurovascular Unit.

Med Sci Monit 2019 Feb 21;25:1373-1382. Epub 2019 Feb 21.

Central Laboratory, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China (mainland).

BACKGROUND Autophagy is characterized by the degradation of cellular components in autophagosomes. It plays a significant role in cerebral ischemic injury and has a complex functional connection with apoptosis. The neurovascular unit (NVU) is a structural and functional unit of the nervous system presented as a therapeutic target of stroke. Read More

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http://dx.doi.org/10.12659/MSM.915123DOI Listing
February 2019

Diagnostic and Management Options of Osteoblastoma in the Spine.

Med Sci Monit 2019 Feb 20;25:1362-1372. Epub 2019 Feb 20.

Department of Bone and Musculoskeletal Tumor Center, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China (mainland).

BACKGROUND Osteoblastoma is a rare, benign, osteolytic neoplasm commonly found in the spine in early adulthood. Here, we review the clinical characteristics, radiographic findings, and surgical management of patients with spinal osteoblastoma. MATERIAL AND METHODS Thirteen patients with osteoblastoma who underwent surgery at our institute from June 2008 to November 2017 were enrolled in this study. Read More

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http://dx.doi.org/10.12659/MSM.913666DOI Listing
February 2019

Antitumor Activity of Asiaticoside Against Multiple Myeloma Drug-Resistant Cancer Cells Is Mediated by Autophagy Induction, Activation of Effector Caspases, and Inhibition of Cell Migration, Invasion, and STAT-3 Signaling Pathway.

Med Sci Monit 2019 Feb 20;25:1355-1361. Epub 2019 Feb 20.

Department of Hematology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China (mainland).

BACKGROUND Accumulating evidence suggests that plant-derived molecules may prove extremely beneficial in the development of chemotherapy for deadly cancer types. Multiple myeloma is a rare and incurable type of cancers. Very little research has been directed towards the development of chemotherapy for the management of multiple myeloma. Read More

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http://dx.doi.org/10.12659/MSM.913397DOI Listing
February 2019

Long-Term Outcomes of Ligation of the Inter-Sphincteric Fistula Tract Plus Bioprosthetic Anal Fistula Plug (LIFT-Plug) in the Treatment of Trans-Sphincteric Perianal Fistula.

Med Sci Monit 2019 Feb 20;25:1350-1354. Epub 2019 Feb 20.

Department of General Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China (mainland).

BACKGROUND The ligation of the inter-sphincteric fistula tract plus bioprosthetic anal fistula plug (LIFT-plug) is a new procedure in the treatment of trans-sphincteric perianal fistulas. The aim of this study was to evaluate its long-term outcomes. MATERIAL AND METHODS Clinical data of 78 patients with trans-sphincteric perianal fistula who were managed by the LIFT-plug technique between March 2014 to October 2016 were analyzed retrospectively. Read More

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http://dx.doi.org/10.12659/MSM.914925DOI Listing
February 2019

CircRNA circ_0067934 Overexpression Correlates with Poor Prognosis and Promotes Thyroid Carcinoma Progression.

Med Sci Monit 2019 Feb 19;25:1342-1349. Epub 2019 Feb 19.

Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China (mainland).

BACKGROUND Circular RNAs are important regulators in human cancers, including thyroid carcinoma. The circ_0067934 RNA is reported to participate in hepatocellular carcinoma, esophageal squamous cell carcinoma, and lung cancer. Whether it regulates thyroid carcinoma remains unclear. Read More

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http://dx.doi.org/10.12659/MSM.913463DOI Listing
February 2019

Silent Cerebral Infarcts Following Left-Sided Accessory Pathway Ablation in Wolff-Parkinson-White (WPW) Syndrome: A Preliminary Report.

Med Sci Monit 2019 Feb 19;25:1336-1341. Epub 2019 Feb 19.

Department of Cardiology, Medical University of Lublin, Lublin, Poland.

BACKGROUND Catheter ablation is a routine procedure in patients with WPW syndrome. Silent cerebral infarcts (SCI) detected in magnetic resonance imaging may be a complication of the ablation procedure, but it is well documented only in atrial fibrillation ablation. Ablation of left-sided accessory pathways (L-AP) has a similar target area, but WPW patients differ from those with atrial fibrillation, due to lower initial risk of cerebral embolic events. Read More

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http://dx.doi.org/10.12659/MSM.914652DOI Listing
February 2019

MiR-34b-3p Represses the Multidrug-Chemoresistance of Bladder Cancer Cells by Regulating the CCND2 and P2RY1 Genes.

Med Sci Monit 2019 Feb 19;25:1323-1335. Epub 2019 Feb 19.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China (mainland).

BACKGROUND Chemoresistance is a main limitation in chemotherapy for therapeutic cancer. MicroRNA (miRNA) has been indicated in the progression and tumorigenesis of many types of cancer, but the effect of miR-34b-3p in bladder cancer (BCa) cells is still unknown. MATERIAL AND METHODS This research compared the multidrug-sensitive (5637) BCa cell line and the multidrug-resistant (EJ) BCa cell line. Read More

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http://dx.doi.org/10.12659/MSM.913746DOI Listing
February 2019

Dynamic Fixation Versus Static Fixation for Distal Tibiofibular Syndesmosis Injuries: A Meta-Analysis.

Med Sci Monit 2019 Feb 18;25:1314-1322. Epub 2019 Feb 18.

Department of Orthopaedics, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, China (mainland).

BACKGROUND Ankle sprains with distal tibiofibular syndesmosis injuries (DTSIs) require anatomic reduction and fixation to restore the normal biomechanics of the ankle joint. In the last decade, dynamic fixation (DF) for DTSIs using a suture-button device has gained popularity because of its advantages over static fixation (SF). MATERIAL AND METHODS The present meta-analysis was conducted to compare clinical outcomes between DF and SF of DTSIs. Read More

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http://dx.doi.org/10.12659/MSM.913324DOI Listing
February 2019

Functional Genetic Single-Nucleotide Polymorphisms (SNPs) in Cyclin-Dependent Kinase Inhibitor 2A/B (CDKN2A/B) Locus Are Associated with Risk and Prognosis of Osteosarcoma in Chinese Populations.

Med Sci Monit 2019 Feb 18;25:1307-1313. Epub 2019 Feb 18.

School of Public Health, Fudan University, Shanghai, China (mainland).

BACKGROUND Cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) encodes several tumor suppressor proteins. Aberrant genetic alterations in CDKN2A/B were found in some malignancies, which were believed to be associated with tumor originating and progression. We hypothesized that CDKN2A/B genetic polymorphisms might be associated with the risk of poorer prognosis of osteosarcoma in Chinese populations. Read More

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http://dx.doi.org/10.12659/MSM.915001DOI Listing
February 2019

Evaluation of Relationship between Occurrence of Liver Cancer and Methylation of Fragile Histidine Triad (FHIT) and P16 Genes.

Med Sci Monit 2019 Feb 18;25:1301-1306. Epub 2019 Feb 18.

Department of Hepatobiliary Surgery, Third Central Hospital of Tianjin (Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health Ministry), Tianjin, China (mainland).

BACKGROUND We examined the level of fragile histidine triad (FHIT) and p16 gene methylation in patients with hepatocellular carcinoma and explored the relationship to liver cancer. MATERIAL AND METHODS There were 56 patients with primary liver cancer who were admitted to the hospital from July 2015 to October 2017 included in the liver cancer group, and 24 non-hepatoma patients (hepatitis A/hepatitis B/hepatitis C, liver cirrhosis, liver fibrosis, and fatty liver, alcoholic liver identified as a control group. Fasting venous blood samples were collected from the 2 groups. Read More

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http://dx.doi.org/10.12659/MSM.912315DOI Listing
February 2019

Phosphatase Actin Regulator-1 (PHACTR-1) Knockdown Suppresses Cell Proliferation and Migration and Promotes Cell Apoptosis in the bEnd.3 Mouse Brain Capillary Endothelial Cell Line.

Med Sci Monit 2019 Feb 17;25:1291-1300. Epub 2019 Feb 17.

Department of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth Peoples' Hospital, Shanghai, China (mainland).

BACKGROUND The phosphatase actin regulator-1 (PHACTR-1) gene on chromosome 6 encodes an actin and protein phosphatase 1 (PP1) binding protein, Phactr-1, which is highly expressed in brain tissues. Phactr-1 expression is involved in physiological and pathological cerebral microvascular events. This study aimed to investigate the role of expression of Phactr-1 in a mouse brain capillary endothelial cell line, bEnd. Read More

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http://dx.doi.org/10.12659/MSM.912586DOI Listing
February 2019
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Ursolic Acid Exhibits Potent Anticancer Effects in Human Metastatic Melanoma Cancer Cells (SK-MEL-24) via Apoptosis Induction, Inhibition of Cell Migration and Invasion, Cell Cycle Arrest, and Inhibition of Mitogen-Activated Protein Kinase (MAPK)/ERK Signaling Pathway.

Med Sci Monit 2019 Feb 17;25:1283-1290. Epub 2019 Feb 17.

Department of Hand and Pediatric Surgery, The First Hospital of Jilin University, Changchun, Jilin, China (mainland).

BACKGROUND Ursolic acid is an important bioactive triterpenoid that has been reported to be of tremendous pharmacological importance. However, the anticancer potential of ursolic acid has not been examined against metastatic melanoma cells. Therefore, in this study we examined the anticancer potential of ursolic acid and its mode of action. Read More

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https://www.medscimonit.com/abstract/index/idArt/913069
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http://dx.doi.org/10.12659/MSM.913069DOI Listing
February 2019
2 Reads

Association Between Activation of the Programmed Cell Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) Pathway and Pain in Patients with Cancer.

Med Sci Monit 2019 Feb 16;25:1275-1282. Epub 2019 Feb 16.

Department of Palliative Care, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).

BACKGROUND The aim of this study was to investigate the clinical correlation between sPD-1 (soluble programmed cell death-1) and PD-1 (programmed cell death-1) expression and cancer pain. MATERIAL AND METHODS sPD-1 content in peripheral blood was determined by enzyme-linked immunosorbent assay (ELISA). T cell surface-positive rate was determined by flow cytometry, and the correlation of clinical characteristics of patients with cancer pain was analyzed. Read More

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http://dx.doi.org/10.12659/MSM.912632DOI Listing
February 2019
1 Read

Acupuncture as an Adjunctive Treatment for Angina Due to Coronary Artery Disease: A Meta-Analysis.

Med Sci Monit 2019 Feb 16;25:1263-1274. Epub 2019 Feb 16.

Department of Gynecology, The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China (mainland).

BACKGROUND In traditional Chinese medicine, acupuncture has been used to treat angina due to coronary artery disease (CAD). The aim of this systematic review of the literature and meta-analysis was to identify published randomized controlled trials (RCTs) that quantified the effectiveness of adjunctive acupuncture treatment in patients with angina due to CAD who were also treated with Western or Chinese medicine. MATERIAL AND METHODS A systematic review of the literature included a search of the PubMed, Embase, Cochrane library, and China National Knowledge Infrastructure (CNKI) databases, from their inception to September 2018. Read More

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https://www.medscimonit.com/abstract/index/idArt/913379
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http://dx.doi.org/10.12659/MSM.913379DOI Listing
February 2019
1 Read

Surgical Resection of Primary Ewing's Sarcoma of Bone Improves Overall Survival in Patients Presenting with Metastasis.

Med Sci Monit 2019 Feb 16;25:1254-1262. Epub 2019 Feb 16.

Department of Orthopaedics, The Affiliated Yangming Hospital of Ningbo University, Yuyao People's Hospital of Zhejiang Province, Yuyao, Zhejiang, China (mainland).

BACKGROUND Metastatic Ewing's sarcoma (ES) of bone has a poor prognosis. Because there have been few previous studies on the prognostic factors and clinical outcome in patients with ES who have metastases at presentation, the aim of this study was to use the Surveillance, Epidemiology, and End Results (SEER) database to compare the clinical outcome following single and combined radiation treatment and surgery. MATERIAL AND METHODS The SEER database was used to identify patients with ES who presented with bone involvement and metastasis between 1973 to 2015. Read More

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http://dx.doi.org/10.12659/MSM.913338DOI Listing
February 2019

Long Non-Coding RNA TFAP2A-AS1 Inhibits Cell Proliferation and Invasion in Breast Cancer via miR-933/SMAD2.

Med Sci Monit 2019 Feb 15;25:1242-1253. Epub 2019 Feb 15.

Department of General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China (mainland).

BACKGROUND It is well documented that long non-coding RNAs (lncRNAs) are involved in the progression of multiple human tumors by sponging microRNAs (miRNAs). However, whether lncRNA TFAP2A-AS1 plays a role in the tumorigenesis of breast cancer (BC) remains undetermined. MATERIAL AND METHODS Real-time PCR (qRT-PCR) assay was performed to detect the relative mRNA expression of TFAP2A-AS1 and miR-933. Read More

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http://dx.doi.org/10.12659/MSM.912421DOI Listing
February 2019

Simvastatin Improves Cardiac Hypertrophy in Diabetic Rats by Attenuation of Oxidative Stress and Inflammation Induced by Calpain-1-Mediated Activation of Nuclear Factor-κB (NF-κB).

Med Sci Monit 2019 Feb 15;25:1232-1241. Epub 2019 Feb 15.

Department of Internal Medicine-Cardiovascular, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China (mainland).

BACKGROUND Simvastatin, an HMG-CoA reductase inhibitor, has been reported to exert multiple protective effects on the cardiovascular system. However, the molecular mechanism remains to be examined. The present study was designed to study the effects of simvastatin on cardiac hypertrophy in diabetic rats and to explore its potential mechanism. Read More

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http://dx.doi.org/10.12659/MSM.913244DOI Listing
February 2019

Resveratrol Reduces Oxidative Stress and Apoptosis in Podocytes via Sir2-Related Enzymes, Sirtuins1 (SIRT1)/Peroxisome Proliferator-Activated Receptor γ Co-Activator 1α (PGC-1α) Axis.

Med Sci Monit 2019 Feb 15;25:1220-1231. Epub 2019 Feb 15.

Department of Nephrology, Third Hospital, Hebei Medical University, Shijiazhuang, Hebei, China (mainland).

BACKGROUND PGC-1α can be activated by deacetylation reactions catalyzed by SIRT1. Resveratrol is currently known as a potent activator of SIRT1. However, it is unknown whether the renal-protective effect of resveratrol is further related to activation of the podocyte SIRT1/PGC-1α pathway. Read More

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http://dx.doi.org/10.12659/MSM.911714DOI Listing
February 2019
1 Read

Knockdown of Long Noncoding RNA POU5F1B Promotes Radiosensitivity in Esophageal Carcinoma.

Med Sci Monit 2019 Feb 14;25:1214-1219. Epub 2019 Feb 14.

Taixing People's Hospital Affiliated to Bengbu Medical College, Bengbu, Anhui, China (mainland).

BACKGROUND POU5F1B, serving as a carcinogen, participates in radiosensitivity of several tumors. However, in esophageal cancer, its potential mechanism and function in regulating radiosensitivity remain unclear. MATERIAL AND METHODS The expression level of POU5F1B was detected in plasma of esophageal tumor patients and cancer cell lines. Read More

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https://www.medscimonit.com/abstract/index/idArt/913066
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http://dx.doi.org/10.12659/MSM.913066DOI Listing
February 2019
4 Reads

The Octamer-Binding Transcription Factor 4 (OCT4) Pseudogene, POU Domain Class 5 Transcription Factor 1B (POU5F1B), is Upregulated in Cervical Cancer and Down-Regulation Inhibits Cell Proliferation and Migration and Induces Apoptosis in Cervical Cancer Cell Lines.

Med Sci Monit 2019 Feb 14;25:1204-1213. Epub 2019 Feb 14.

Taixing Peoples' Hospital Affiliated to Bengbu Medical College, Taixing, Jiangsu, China (mainland).

BACKGROUND The POU domain class 5 transcription factor 1B (POU5F1B), is a pseudogene that is homologous to octamer-binding transcription factor 4 (OCT4), and is located adjacent to the MYC gene on human chromosome 8q24. POU5F1B has been reported to be transcribed in several types of cancer, but its role in cervical cancer remains unclear. This study aimed to investigate the expression and function of POU5F1B in tissue samples of human cervical cancer and in cervical cancer cell lines in vitro. Read More

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http://dx.doi.org/10.12659/MSM.912109DOI Listing
February 2019
3 Reads

Myocardial Performance in Elite Athletes: The Role of Homocysteine, Iron, and Lipids.

Authors:
Serkan Duyuler

Med Sci Monit 2019 Feb 14;25:1194-1203. Epub 2019 Feb 14.

Cardiology Clinic, Acıbadem Ankara Hospital, Acıbadem University, Ankara, Turkey.

BACKGROUND The myocardial performance index (MPI) is a comprehensive measure of global systolic and diastolic function of the ventricle, and it has an inverse correlation with maximal oxygen consumption. In this study, the potential association between left ventricle MPI and biochemical biomarkers (including iron, homocysteine, and lipids) in elite athletes was investigated. MATERIAL AND METHODS This cross-sectional observational study consisted of 80 young male elite soccer and basketball players (age: 18-34 years) examined for a seasonal medical check-up. Read More

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http://dx.doi.org/10.12659/MSM.913561DOI Listing
February 2019
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Comparison of Remifentanil-Based Fast-Track and Fentanyl-Based Routine Cardiac Anesthesia for Intraoperative Device Closure of Atrial Septal Defect (ASD) in Pediatric Patients.

Med Sci Monit 2019 Feb 13;25:1187-1193. Epub 2019 Feb 13.

Department of Anesthesia, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China (mainland).

BACKGROUND The aim of this study was to evaluate the effectiveness and safety of remifentanil-based fast-track anesthesia for intraoperative device closure of atrial septal defects (ASDs). MATERIAL AND METHODS The clinical data of 152 pediatric patients who received intraoperative device closure of ASD in our hospital from January 2015 to December 2017 were retrospectively analyzed. Patients were divided into 2 groups: group F (remifentanil-based fast-track anesthesia group, n=72) and group C (fentanyl-based routine anesthesia group, n=80). Read More

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http://dx.doi.org/10.12659/MSM.913387DOI Listing
February 2019
3 Reads

Notoginsenoside R1 (NGR1) Attenuates Chronic Atrophic Gastritis in Rats.

Med Sci Monit 2019 Feb 13;25:1177-1186. Epub 2019 Feb 13.

External Liaison Office, Second Affiliated Hospital of Nanjing University of Chinese Medicine (Second Hospital of Jiangsu Province), Nanjing, Jiangsu, China (mainland).

BACKGROUND This study investigated the effect and mechanism of notoginsenoside R1 (NGR1) on chronic atrophic gastritis (CAG) in a rat model. MATERIAL AND METHODS To perform our investigation, a rat model of CAG was established, and then rats were treated with various doses of NGR1. After treatment, hematoxylin-eosin (HE) staining was used for histopathological observation and further scoring. Read More

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http://dx.doi.org/10.12659/MSM.911512DOI Listing
February 2019
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Comparison of the Use of Vonoprazan and Proton Pump Inhibitors for the Treatment of Peptic Ulcers Resulting from Endoscopic Submucosal Dissection: A Systematic Review and Meta-Analysis.

Med Sci Monit 2019 Feb 13;25:1169-1176. Epub 2019 Feb 13.

Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China (mainland).

BACKGROUND Currently, proton pump inhibitors (PPIs) are the first-line treatment for ulcers resulting from endoscopic submucosal dissection (ESD). Vonoprazan is a new oral potassium-competitive acid blocker (P-CAB). The aim of this systematic review and meta-analysis was to compare the efficacy, safety, and tolerance of vonoprazan with PPIs in the treatment of peptic ulcers resulting from ESD. Read More

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https://www.medscimonit.com/abstract/index/idArt/911886
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http://dx.doi.org/10.12659/MSM.911886DOI Listing
February 2019
4 Reads

A Comparative Study on Functional Recovery, Complications, and Changes in Inflammatory Factors in Patients with Thoracolumbar Spinal Fracture Complicated with Nerve Injury Treated by Anterior and Posterior Decompression.

Med Sci Monit 2019 Feb 12;25:1164-1168. Epub 2019 Feb 12.

Department of Surgery, Baotou Central Hospital, Baotou, Inner Mongolia, China (mainland).

BACKGROUND The aim of this study was to evaluate 2 methods to treat patients with thoracic lumbar spine fracture with merging spinal cord injury, including complications of surgery and the influence of inflammatory factors. MATERIAL AND METHODS Eighty patients were randomly divided into an anterior decompression group (study group) or a posterior decompression group (control group) to observe perioperative complications, evaluate preoperative and postoperative nerve function, and evaluate the 6-month injured vertebral height and Cobb angle of the vertebral bodies. The expression level of TGF-β₂ on day 1, day 7, day 15, and day 30 after treatment was detected by enzyme-linked immunosorbent assay (ELISA). Read More

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http://dx.doi.org/10.12659/MSM.912332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380160PMC
February 2019

Comparative Efficacy of Budesonide/Formoterol with Budesonide, Formoterol or Placebo for Stable Chronic Obstructive Pulmonary Disease: A Meta-Analysis.

Med Sci Monit 2019 Feb 12;25:1155-1163. Epub 2019 Feb 12.

Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).

BACKGROUND The 2018 Global Initiative for Chronic Obstructive Lung Disease publication suggested that the combination of bronchodilator therapy of inhaled glucocorticoid/long-acting β₂ adrenoceptor agonist is more effective in improving pulmonary function and health status in the treatment of patients with acute exacerbations than the individual components; however, it is not known whether this also the case for stable chronic obstructive pulmonary disease (COPD). The purpose of this meta-analysis was to evaluate the effectiveness of budesonide/formoterol in the maintenance and relief therapy of patients with stable COPD. MATERIAL AND METHODS An electronic search of the literature in MEDLINE, Embase, and Cochrane Central Register of Controlled Trials was undertaken to identify published randomized controlled trials (RCTs) of ≥12 weeks duration comparing the budesonide/formoterol, with budesonide, formoterol, or placebo in the treatment of patients with stable COPD. Read More

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http://dx.doi.org/10.12659/MSM.912033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380161PMC
February 2019
2 Reads

Identification of RNA Expression Profiles in Thyroid Cancer to Construct a Competing Endogenous RNA (ceRNA) Network of mRNAs, Long Noncoding RNAs (lncRNAs), and microRNAs (miRNAs).

Med Sci Monit 2019 Feb 12;25:1140-1154. Epub 2019 Feb 12.

Department of Nursing, The Hospital of Heilongjiang Province, Harbin, Heilongjiang, China (mainland).

BACKGROUND The aims of this study were to use RNA expression profile bioinformatics data from cases of thyroid cancer from the Cancer Genome Atlas (TCGA), the Kyoto Encyclopedia of Genes and Genomes (KEGG), and the Gene Ontology (GO) databases to construct a competing endogenous RNA (ceRNA) network of mRNAs, long noncoding RNAs (lncRNAs), and microRNAs (miRNAs). MATERIAL AND METHODS TCGA provided RNA profiles from 515 thyroid cancer tissues and 56 normal thyroid tissues. The DESeq R package analyzed high-throughput sequencing data on differentially expressed RNAs. Read More

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http://dx.doi.org/10.12659/MSM.912450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380385PMC
February 2019

Expression of a Novel Long Noncoding RNA (lncRNA), GASL1, is Downregulated in Patients with Intracranial Aneurysms and Regulates the Proliferation of Vascular Smooth Muscle Cells In Vitro.

Med Sci Monit 2019 Feb 11;25:1133-1139. Epub 2019 Feb 11.

Department of Gastroenterology, Centre Hospital of Weihai, Weihai, Shandong, China (mainland).

BACKGROUND Preliminary microarray data in our laboratory indicated that the novel long noncoding RNA (lncRNA), GASL1, was downregulated in patients with intracranial aneurysms. This study aimed to investigate the expression of lncRNA GASL1 in patients with intracranial aneurysms and its role in the regulation of vascular smooth muscle cell (VSMC) proliferation by transforming growth factor-β1 (TGF-β1). MATERIAL AND METHODS The study included 68 patients with unruptured intracranial aneurysms and 56 healthy volunteers. Read More

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http://dx.doi.org/10.12659/MSM.912204DOI Listing
February 2019
1 Read

microRNA-205 and microRNA-338-3p Reduces Cell Apoptosis in Prostate Carcinoma Tissue and LNCaP Prostate Carcinoma Cells by Directly Targeting the B-Cell Lymphoma 2 (Bcl-2) Gene.

Med Sci Monit 2019 Feb 11;25:1122-1132. Epub 2019 Feb 11.

Department of Oncology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland).

BACKGROUND The inhibitor of apoptosis, B-cell lymphoma 2 (Bcl-2), is encoded by the BCL2 gene. Previous studies have shown that microRNAs are downregulated in prostate cancer. This study aimed to investigate the role of microRNA-205 and microRNA-338-3p and cell apoptosis in prostate carcinoma tissue and the LNCaP human prostate adenocarcinoma cell line by directly targeting the BCL2 gene and Bcl-2 protein expression. Read More

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http://dx.doi.org/10.12659/MSM.912148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380162PMC
February 2019
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Myosin Heavy Chain 9: Oncogene or Tumor Suppressor Gene?

Med Sci Monit 2019 01 31;25:888-892. Epub 2019 Jan 31.

First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, Shaanxi, China (mainland).

MYH9 was first discovered due to thrombocytopenia caused by MYH9 mutation-related abnormalities. In recent years, researchers have increasingly found that MYH9 plays an important role in cancer as a cytokine involved in cytoskeletal reorganization, cellular pseudopodia formation, and migration. MYH9 is closely related to the progress and poor prognosis of most solid tumors, and it is now accepted that MYH9 is a suppressor gene and plays an important role on the re-Rho pathway. Read More

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http://dx.doi.org/10.12659/MSM.912320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366299PMC
January 2019
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Fangchinoline Ameliorates Diabetic Retinopathy by Inhibiting Receptor for Advanced Glycation End-Products (RAGE)-Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κB) Pathway in Streptozotocin (STZ)-Induced Diabetic Rats.

Med Sci Monit 2019 Feb 11;25:1113-1121. Epub 2019 Feb 11.

Department of Ophthalmology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China (mainland).

BACKGROUND Diabetic retinopathy (DR) is a macrovascular complication that occurs in diabetic patients. Conventional treatments for the management of DR have many limitations. Thus, the present investigation evaluated the protective effect of fangchinoline against diabetic retinopathy (DR). Read More

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http://dx.doi.org/10.12659/MSM.912927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380384PMC
February 2019
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Advanced Hepatocellular Carcinoma with Bone Metastases: Prevalence, Associated Factors, and Survival Estimation.

Med Sci Monit 2019 Feb 10;25:1105-1112. Epub 2019 Feb 10.

Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Moscow, Russian Federation.

BACKGROUND The objective of the present research was to explore the prevalence, risk, and prognostic factors associated with bone metastases (BM) in newly diagnosed hepatocellular carcinoma (HCC) patients. MATERIAL AND METHODS From 36 507 HCC patients who were registered in Surveillance, Epidemiology, and End Results (SEER) database, we enrolled 1263 with BM at the initial diagnosis of HCC from 2010 to 2014. Kaplan-Meier curves and log-rank tests were used to estimate overall survival for different subgroups. Read More

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http://dx.doi.org/10.12659/MSM.913470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378855PMC
February 2019
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Anti-Diabetogenic Properties of Mineralocorticoid Receptor Antagonists: Implications for Enhanced Safety and Efficacy of Post-Transplantation Pharmacotherapies.

Med Sci Monit 2019 Feb 10;25:1102-1104. Epub 2019 Feb 10.

Transplantation Center, Third Xiangya Hospital of Central South University, Engineering and Technology Research Center for Transplantation Medicine of National Ministry of Health, Changsha, Hunan, China (mainland).

Widespread usage of the calcineurin inhibitors tacrolimus and cyclosporine A as post-transplantation immunosuppressive agents is fraught with severe nephrotoxic and diabetogenic side effects. More recently, tapering of calcineurin inhibitor-based immunotherapies with concurrent administration of the mammalian target of rapamycin (mTOR) inhibitors sirolimus and everolimus has been employed within pharmacological regimens designed to achieve better safety and efficacy for preservation of allograft kidney function. Collected preclinical data and recent clinical study, however, indicate that usage of calcineurin inhibitors and/or mTOR blockers as immunosuppressive agents promotes equivalent diabetogenic side effects. Read More

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http://dx.doi.org/10.12659/MSM.914340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378856PMC
February 2019

A Comparative Study of Bolus Norepinephrine, Phenylephrine, and Ephedrine for the Treatment of Maternal Hypotension in Parturients with Preeclampsia During Cesarean Delivery Under Spinal Anesthesia.

Med Sci Monit 2019 Feb 9;25:1093-1101. Epub 2019 Feb 9.

Department of Anesthesiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (mainland).

BACKGROUND This study aimed to compare the efficacy and safety of bolus norepinephrine, phenylephrine, and ephedrine in parturient with preeclampsia who had hypotension during cesarean delivery under spinal anesthesia. MATERIAL AND METHODS One hundred and sixty-six parturient women with preeclampsia who had a baseline systolic blood pressure (SBP) <80% during spinal anesthesia for cesarean section were divided into three treatment groups; bolus norepinephrine 4 μg (group N) (n=56), phenylephrine 50 μg (group P) (n=55), and ephedrine 4 mg (group E) (n=55). Primary outcomes included overall SBP and heart rate (HR) until delivery. Read More

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http://dx.doi.org/10.12659/MSM.914143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377586PMC
February 2019
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CYFRA 21-1 and Placental Growth Factor as Screening Markers for Endometriosis.

Med Sci Monit 2019 Feb 9;25:1087-1092. Epub 2019 Feb 9.

Department of Obstetrics and Gynecology, Hallym University Dongtan Sacred Heart Hospital, Kyeonggido, South Korea.

BACKGROUND This study evaluated the performance of serum CYFRA 21-1 and placental growth factor (PIGF) as screening markers for endometriosis. MATERIAL AND METHODS In this prospective study included 81 female patients who underwent laparoscopy to treat benign ovarian tumors. Serum samples were obtained from all study patients before surgery. Read More

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http://dx.doi.org/10.12659/MSM.912787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377587PMC
February 2019
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Correlation Between Adiponectin Gene rs1501299 Polymorphism and Nonalcoholic Fatty Liver Disease Susceptibility: A Systematic Review and Meta-Analysis.

Med Sci Monit 2019 Feb 8;25:1078-1086. Epub 2019 Feb 8.

Department of Clinical Laboratory, The 81st Hospital of People's Liberation Army (PLA), Nanjing, Jiangsu, China (mainland).

BACKGROUND Metabolic related nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases around the world. A single nucleotide polymorphism (SNP) rs1501299 (+276G>T) in the adiponectin gene has been recently revealed to be responsible for susceptibility to NAFLD. This meta-analysis intended to assess the association risk of NAFLD and rs1501299 polymorphism. Read More

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http://dx.doi.org/10.12659/MSM.912737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376635PMC
February 2019

Occupational Factors Causing Pain Among Nurses in Mainland China.

Med Sci Monit 2019 Feb 8;25:1071-1077. Epub 2019 Feb 8.

Nursing Department, West China Hospital, Sichuan University, Chengdu, Sichuan, China (mainland).

BACKGROUND Pain is a common problem affecting the wellbeing of nurses. This study investigated physical pain of nurses and their pain self-management in mainland China. MATERIAL AND METHODS A total of 2458 full-time nurses working in 18 hospitals across mainland China were studied from May 2016 to July 2016, of which a total of 1269 nurses (51. Read More

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http://dx.doi.org/10.12659/MSM.912356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376633PMC
February 2019
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HIPK1 Interference Attenuates Inflammation and Oxidative Stress of Acute Lung Injury via Autophagy.

Med Sci Monit 2019 Jan 29;25:827-835. Epub 2019 Jan 29.

Department of Obstetrics, Qingdao Municipal Hospital of Shandong Province, Qingdao, Shandong, China (mainland).

BACKGROUND Acute respiratory distress syndrome (ARDS), which is characterized by severe hypoxemia (PaO2/FIO2 ≤300 mmHg), is usually companied by uncontrolled inflammation, oxidative injury, and the damage to the alveolar-capillary barrier. Severe ARDS is usually companied with acute lung injury that worsen the patients' condition. HIPK1 is a modulator of homeodomain-containing transcription factors and regulates multiple cellular biological process associated with inflammation and anti-stress responses. Read More

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http://dx.doi.org/10.12659/MSM.912507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362758PMC
January 2019
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Association of Dietary Potassium Intake with the Development of Chronic Kidney Disease and Renal Function in Patients with Mildly Decreased Kidney Function: The Korean Multi-Rural Communities Cohort Study.

Med Sci Monit 2019 Feb 8;25:1061-1070. Epub 2019 Feb 8.

Department of Preventive Medicine, Keimyung University School of Medicine, Daegu, South Korea.

BACKGROUND Dietary potassium has negative outcomes in patients with mildly impaired kidney function, while having positive outcomes in patients with hypertension. The association of dietary potassium intake with chronic kidney disease (CKD) development, with presence of hypertension, was studied in the Korean rural population with mildly impaired kidney function. MATERIAL AND METHODS From 3 rural areas of Korea, 5064 participants age ≥40 with CKD stage 2 at baseline were recruited. Read More

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http://dx.doi.org/10.12659/MSM.913504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376634PMC
February 2019
2 Reads

Effectiveness of Parecoxib Sodium Combined with Transversus Abdominis Plane Block for Pain Management After Hepatectomy for Hepatocellular Carcinoma: A Prospective Controlled Study.

Med Sci Monit 2019 Feb 7;25:1053-1060. Epub 2019 Feb 7.

Department of General Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China (mainland).

BACKGROUND This study aimed to investigate the effectiveness of perioperative parecoxib sodium combined with transversus abdominis plane (TAP) block on postoperative pain management following hepatectomy in patients with hepatocellular carcinoma (HCC). MATERIAL AND METHODS One hundred patients with HCC who underwent hepatectomy were randomized into a study group (n=51) and a control group (n=49). The study group received 40 mg of parecoxib sodium 30 minutes before anesthetic induction, and 150 mg of 0. Read More

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http://dx.doi.org/10.12659/MSM.912843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375540PMC
February 2019
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Comparison of Quantitative Electroencephalogram During Sleep in Depressed and Non-Depressed Patients with Parkinson's Disease.

Med Sci Monit 2019 Feb 7;25:1046-1052. Epub 2019 Feb 7.

Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).

BACKGROUND Depression is one of the most important factors affecting quality of life in Parkinson's patients. Most research on Parkinson's disease with depression has focused on neuroimaging, and there have been few quantitative electroencephalogram studies. Sleep is a biomarker for depression; therefore, the aim of this study was to identify differences in quantitative electroencephalograms during sleep in depressed and non-depressed patients with Parkinson's disease. Read More

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http://dx.doi.org/10.12659/MSM.913931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375285PMC
February 2019
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Probucol Protects Against Contrast-Induced Acute Kidney Injury via the Extracellular Signal-Regulated Kinases 1 and 2 (ERK1/2)/JNK-Caspase 3 Pathway in Diabetic Rats.

Med Sci Monit 2019 Feb 7;25:1038-1045. Epub 2019 Feb 7.

Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China (mainland).

BACKGROUND Contrast-induced acute kidney injury is an important clinical problem, yet its pathogenic mechanisms are incompletely understood. In this study we explored the potential beneficial effects of probucol as treatment of contrast-induced acute kidney injury in diabetic rats. MATERIAL AND METHODS Rats were divided into 3 groups: i) diabetic control, ii) diabetic with contrast, and iii) probucol treatment groups. Read More

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http://dx.doi.org/10.12659/MSM.913106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375284PMC
February 2019
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Assessment of Clinical and Echocardiographic Findings of Pregnant Women with Dyspnea.

Med Sci Monit 2019 Feb 6;25:1032-1037. Epub 2019 Feb 6.

Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul Health Sciences University, Istanbul, Turkey.

BACKGROUND In the present study we evaluated clinical and echocardiography findings of pregnant women with dyspnea. MATERIAL AND METHODS Pregnant women with and without dyspnea and admitted to the Gynecology and Obstetrics Clinic of a tertiary hospital between December 2017 and June 2018 were enrolled in this case-control study. All patients underwent echocardiography in the third trimester (≥27 weeks). Read More

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http://dx.doi.org/10.12659/MSM.913174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373241PMC
February 2019
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Altered Corneal Nerves in Chinese Thyroid-Associated Ophthalmopathy Patients Observed by In Vivo Confocal Microscopy.

Med Sci Monit 2019 Feb 6;25:1024-1031. Epub 2019 Feb 6.

Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, Shanghai, China (mainland).

BACKGROUND Thyroid-associated ophthalmopathy (TAO) is a common endocrine autoimmune disease. The present study explored corneal nerve changes in TAO patients. MATERIAL AND METHODS Thirty-eight Chinese TAO patients and 20 healthy individuals were included in the study. Read More

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https://www.medscimonit.com/abstract/index/idArt/912310
Publisher Site
http://dx.doi.org/10.12659/MSM.912310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373222PMC
February 2019
2 Reads

Perspectives of New Advances in the Pathogenesis of Vitiligo: From Oxidative Stress to Autoimmunity.

Med Sci Monit 2019 Feb 6;25:1017-1023. Epub 2019 Feb 6.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China (mainland).

Vitiligo is an autoimmune cutaneous disease in which melanocytes are destroyed by CD8⁺ T cells resulting in disfiguring white spots. From the very beginning of the disease, oxidative stress plays a significant role in promoting the onset of vitiligo, as noted by many studies. Multiple factors lead to the overproduction of reactive oxygen species (ROS), and collaboratively cause ROS accumulation in vulnerable melanocytes. Read More

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https://www.medscimonit.com/abstract/index/idArt/914898
Publisher Site
http://dx.doi.org/10.12659/MSM.914898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373225PMC
February 2019
2 Reads