2,542 results match your criteria Medical Mycology [Journal]


Impact of dose adaptations following voriconazole therapeutic drug monitoring in pediatric patients.

Med Mycol 2019 Feb 13. Epub 2019 Feb 13.

Radboud university medical center, Department of Pharmacy and Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

Voriconazole is the mainstay of treatment for invasive aspergillosis in immunocompromised pediatric patients. Although Therapeutic Drug Monitoring (TDM) of voriconazole is recommended, it remains unknown if TDM-based dose adaptations result in target attainment. Patients <19 years from two pediatric hematologic-oncology wards were retrospectively identified based on unexplained high voriconazole trough concentrations (Cmin > 6 mg/l). Read More

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http://dx.doi.org/10.1093/mmy/myz006DOI Listing
February 2019

Increased virulence of albino mutant of Fonsecaea monophora in Galleria mellonella.

Med Mycol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biological Sciences, Youngstown State University, One University Plaza, Youngstown, OH, USA.

Fonsecaea monophora has been the predominant pathogen of chromoblastomycosis in Southern China, but its pathogenic mechanism remains unclear. New models are needed to study this infection. In the current study, we examined the role of melanin on the pathogenicity of F. Read More

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http://dx.doi.org/10.1093/mmy/myz007DOI Listing
February 2019

The serine peptidase inhibitor TPCK induces several morphophysiological changes in the opportunistic fungal pathogen Candida parapsilosis sensu stricto.

Med Mycol 2019 Feb 9. Epub 2019 Feb 9.

Laboratório de Estudos Avançados de Microrganismos Emergentes e Resistentes, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Candida parapsilosis sensu stricto (C. parapsilosis) has emerged as the second/third commonest Candida species isolated from hospitals worldwide. Candida spp. Read More

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http://dx.doi.org/10.1093/mmy/myz008DOI Listing
February 2019

Experimental Candida albicans osteomyelitis: Microbiologic, antigenic, histologic, and 18FDG-PET-CT imaging characteristics in a newly established rabbit model.

Med Mycol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Candida osteomyelitis is a debilitating disease that is difficult to diagnose and treat. As there are no animal models or prospective studies for this uncommon infection, little is known about the pathogenesis, diagnosis, or treatment. We therefore sought to establish an animal model for the study of the pathophysiology, diagnostic modalities, and therapeutic interventions of Candida osteomyelitis. Read More

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http://dx.doi.org/10.1093/mmy/myz001DOI Listing
February 2019
1 Read

Use of Aspergillus fumigatus real-time PCR in bronchoalveolar lavage samples (BAL) for diagnosis of invasive aspergillosis, including azole-resistant cases, in high risk haematology patients: the need for a combined use with galactomannan.

Med Mycol 2019 Feb 7. Epub 2019 Feb 7.

Division of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.

Diagnosis of invasive aspergillosis (IA) is challenging, particularly in high-risk patients with lung lesions other than typical according to 2008-EORTC/MSG criteria. Even if microbiology is positive, they still remain unclassified according to 2008-EORTC/MSG. Quantitative polymerase chain reaction (qPCR) provides new mycological documentation of IA. Read More

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http://dx.doi.org/10.1093/mmy/myz002DOI Listing
February 2019

Erratum: Candida auris: The recent emergence of a multidrug-resistant fungal Pathogen.

Med Mycol 2019 Feb 4. Epub 2019 Feb 4.

Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1093/mmy/myy156DOI Listing
February 2019

Coccidioidomycosis: What a long strange trip it's been.

Med Mycol 2019 Feb;57(Supplement_1):S3-S15

California Institute for Medical Research, San Jose, California, USA.

The recorded history of coccidioidomycosis began in 1892 with the report of the illness of Domingo Escurra by Alejandro Posadas followed by a description of the first North American cases by Rixford and Gilchrist. Originally considered a protozoan, William Ophüls determined that Coccidioides was a fungus and that the lungs were the apparent initial site of infection. During the 1930s, both Gifford and Dickson determined that a self-limited illness, Valley Fever, was caused by the same fungus that caused the often fatal coccidioidal granuloma. Read More

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http://dx.doi.org/10.1093/mmy/myy123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347081PMC
February 2019
2 Reads

Coccidioides ecology and genomics.

Med Mycol 2019 Feb;57(Supplement_1):S21-S29

Department of Microbiology, Centro de Investigación Científica y Educación Superior de Ensenada (CICESE), Ctra. Ensenada-Tijuana No. 3918, Ensenada, Baja California, 22860, Mexico.

Although the natural history and ecology of Coccidioides spp. have been studied for over 100 years, many fundamental questions about this fungus remain unanswered. Two of the most challenging aspects of the study of Coccidioides have been the undefined ecological niche and the outdated geographic distribution maps dating from midcentury. Read More

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http://dx.doi.org/10.1093/mmy/myy051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347077PMC
February 2019
2.335 Impact Factor

The 7th International Coccidioidomycosis Symposium.

Authors:

Med Mycol 2019 Feb;57(Supplement_1):S1-S2

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http://dx.doi.org/10.1093/mmy/myy152DOI Listing
February 2019
1 Read

The endozoan, small-mammal reservoir hypothesis and the life cycle of Coccidioides species.

Med Mycol 2019 Feb;57(Supplement_1):S16-S20

Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.

The prevailing hypothesis concerning the ecology of Coccidioides immitis and C. posadasii is that these human pathogenic fungi are soil fungi endemic to hot, dry, salty regions of the New World and that humans and the local, small-mammal fauna are only accidental hosts. Here we advance an alternative hypothesis that Coccidioides spp. Read More

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https://academic.oup.com/mmy/article/57/Supplement_1/S16/530
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http://dx.doi.org/10.1093/mmy/myy039DOI Listing
February 2019
3 Reads
2.335 Impact Factor

A review of innate and adaptive immunity to coccidioidomycosis.

Med Mycol 2019 Feb;57(Supplement_1):S85-S92

Infectious Diseases Section, VA Healthcare San Diego, California, USA.

Coccidioidomycosis is a human fungal disease cause by inhalation of aerosol spores produced by Coccidioides posadasii or Coccidioides immitis. This disease is a common cause of community-acquired pneumonia in the endemic areas of the Southwestern United States. It also can present as a life-threatening disease as the fungal cells disseminate to skin, bone, and central nervous system. Read More

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http://dx.doi.org/10.1093/mmy/myy146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347076PMC
February 2019
3 Reads

Current Concepts and Future Directions in the Pharmacology and Treatment of Coccidioidomycosis.

Med Mycol 2019 Feb;57(Supplement_1):S76-S84

Division of Infectious Diseases, UT Health San Antonio, and the South Texas Veterans Health Care System; San Antonio, Texas, USA.

Coccidioidomycosis remains a significant clinical problem with substantial morbidity and mortality. The vast majority of infections are asymptomatic and the need for early primary therapy remains controversial. The use of triazole antifungals has improved tolerability of therapy but concerns about acute and long-term toxicities among available agents limit their use. Read More

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https://academic.oup.com/mmy/article/57/Supplement_1/S76/530
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http://dx.doi.org/10.1093/mmy/myy029DOI Listing
February 2019
4 Reads

Selected Clinical Features of Coccidioidomycosis in Dogs.

Med Mycol 2019 Feb;57(Supplement_1):S67-S75

School of Veterinary Medicine, University of California-Davis, Davis, California, USA.

Canine coccidioidomycosis, a systemic fungal infection endemic to arid and semiarid regions of North, Central, and South America, is commonly diagnosed in dogs living in or traveling through lower Sonoran life zones in the states of California and Arizona. Canine and human cases have geographic overlap. Similarities between clinical coccidioidomycosis in dogs and humans include asymptomatic infection, primary respiratory disease and disseminated disease. Read More

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https://academic.oup.com/mmy/article/57/Supplement_1/S67/530
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http://dx.doi.org/10.1093/mmy/myy113DOI Listing
February 2019
5 Reads

Update on the Epidemiology of coccidioidomycosis in the United States.

Med Mycol 2019 Feb;57(Supplement_1):S30-S40

Maricopa County Department of Public Health, Phoenix, Arizona, USA.

The incidence of reported coccidioidomycosis in the past two decades has increased greatly; monitoring its changing epidemiology is essential for understanding its burden on patients and the healthcare system and for identifying opportunities for prevention and education. We provide an update on recent coccidioidomycosis trends and public health efforts nationally and in Arizona, California, and Washington State. In Arizona, enhanced surveillance shows that coccidioidomycosis continues to be associated with substantial morbidity. Read More

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http://dx.doi.org/10.1093/mmy/myy095DOI Listing
February 2019
1 Read

Epidemiology of coccidioidomycosis among children in California, 2000-2016.

Med Mycol 2019 Feb;57(Supplement_1):S64-S66

Infectious Diseases Branch, California Department of Public Health, Richmond, California.

We calculated population-based incidence of coccidioidomycosis from the 2000-2016 California surveillance data and compared children (≤17 years) with adults (≥18 years). During that time, the annual pediatric incidence per 100,000 increased from 0.8 in 2000 to 5. Read More

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http://dx.doi.org/10.1093/mmy/myy066DOI Listing
February 2019
1 Read

Coccidioidomycosis in Latin America.

Med Mycol 2019 Feb;57(Supplement_1):S46-S55

CIPTIR, Hospital Universitario de Monterrey UANL, Mexico.

Coccidioidomycosis is a highly prevalent systemic mycosis in Latin America and has been reported (human and zoonotic cases) in México, Guatemala, Honduras, Colombia, Venezuela, Brazil, Paraguay, Bolivia, and Argentina. The incidence of coccidioidomycosis in Latin America is unknown due to lack of clinical awareness and limited access to laboratory diagnosis. Coccidioidomycosis is as prevalent in Mexico as in the endemic regions of the United States. Read More

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http://dx.doi.org/10.1093/mmy/myy037DOI Listing
February 2019
1 Read

Occupational coccidioidomycosis surveillance and recent outbreaks in California.

Med Mycol 2019 Feb;57(Supplement_1):S41-S45

United States Public Health Service Commissioned Corps, Rockville, Maryland, USA.

Workers in Coccidioides-endemic areas performing soil-disturbing work or exposed to windy and dusty conditions are at increased risk for coccidioidomycosis. Four occupational coccidioidomycosis outbreaks from 2007 to 2014 in California are described, involving construction workers in a number of excavation projects and an outdoor filming event involving cast and crew. These outbreaks highlight the importance of identifying industries and occupations at high risk for coccidioidomycosis, conducting targeted occupational health surveillance to assess the burden of illness, developing and implementing prevention strategies, and setting research priorities. Read More

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http://dx.doi.org/10.1093/mmy/myy031DOI Listing
February 2019
2 Reads

Prospective multicenter surveillance of clinically isolated Aspergillus species revealed azole-resistant Aspergillus fumigatus isolates with TR34/L98H mutation in the Kyoto and Shiga regions of Japan.

Med Mycol 2019 Jan 25. Epub 2019 Jan 25.

Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

The prevalence of azole-resistant Aspergillus fumigatus (ARAF) in Japan is unclear. We aimed to investigate the epidemiology of clinically isolated Aspergillus species and the frequency of azole resistance in Aspergillus species, particularly Aspergillus fumigatus, in the Kyoto and Shiga regions of Japan. Strains of clinically isolated Aspergillus species were prospectively collected from nine acute care hospitals. Read More

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https://academic.oup.com/mmy/advance-article/doi/10.1093/mmy
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http://dx.doi.org/10.1093/mmy/myz003DOI Listing
January 2019
3 Reads

Multi-centric evaluation of the online MSI platform for the identification of cryptic and rare species of Aspergillus by MALDI-TOF.

Med Mycol 2019 Jan 25. Epub 2019 Jan 25.

AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Parasitologie Mycologie, F-75013 Paris, France.

The taxonomy of Aspergillus species has recently been revolutionized with the introduction of cryptic species and section concepts. However, their species-level identification in routine laboratories remains a challenge. The aim of this study was to prospectively assess the identification accuracy of cryptic species of Aspergillus in various laboratories using the mass spectrometry identification (MSI) platform, an independent and freely accessible online mass spectrometry database. Read More

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http://dx.doi.org/10.1093/mmy/myz004DOI Listing
January 2019
1 Read

Progressive disseminated histoplasmosis in Latin America and the Caribbean in people receiving highly active antiretroviral therapy for HIV infection: A systematic review.

Med Mycol 2019 Jan 18. Epub 2019 Jan 18.

Departamento de Infectología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, México.

Histoplasmosis is the most clinically significant mycosis in Latin America; still it has been neglected in people with human immunodeficiency virus (HIV). There is limited information about its contribution to morbidity and mortality in this population. We conducted a systematic review of scientific literature to provide an estimation of the frequency and mortality of histoplasmosis among people with HIV receiving highly active antiretroviral therapy (HAART) in Latin America, and factors associated with mortality. Read More

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https://academic.oup.com/mmy/advance-article/doi/10.1093/mmy
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http://dx.doi.org/10.1093/mmy/myy143DOI Listing
January 2019
4 Reads

Neutrophil-mediated antifungal activity against highly virulent Cryptococcus gattii strain R265.

Med Mycol 2019 Jan 18. Epub 2019 Jan 18.

Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.

Vaccine-induced immune responses, including neutrophil, macrophage, and T-cell responses, ameliorate cryptococcosis caused by Cryptococcus gattii. However, whether neutrophils can exert fungicidal activity against C. gattii remains to be elucidated. Read More

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https://academic.oup.com/mmy/advance-article/doi/10.1093/mmy
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http://dx.doi.org/10.1093/mmy/myy153DOI Listing
January 2019
7 Reads

Comparative antifungal susceptibility analyses of Cryptococcus neoformans VNI and Cryptococcus gattii VGII from the Brazilian Amazon Region by the Etest, Vitek 2, and the Clinical and Laboratory Standards Institute broth microdilution methods.

Med Mycol 2019 Jan 17. Epub 2019 Jan 17.

Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, INI/Fiocruz, Rio de Janeiro, RJ.

Early diagnosis, efficient clinical support, and proper antifungal therapy are essential to reduce death and sequels caused by cryptococcosis. The emergence of resistance to the antifungal drugs commonly used for cryptococcosis treatment is an important issue of concern. Thus, the in vitro antifungal susceptibility of clinical strains from northern Brazil, including C. Read More

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http://dx.doi.org/10.1093/mmy/myy150DOI Listing
January 2019
1 Read

Prevalence and antifungal susceptibility of Sporothrix species in Jiangxi, central China.

Med Mycol 2019 Jan 16. Epub 2019 Jan 16.

Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.

Sporotrichosis is a subcutaneous mycosis caused by traumatic inoculation of pathogenic Sporothrix species. Until recently, Sporothrix globosa was considered as the unique Chinese species causing this disorder. In the present study, 33 clinical Sporothrix strains isolated from Jiangxi, China, were classified and antifungal susceptibility for each strain was determined. Read More

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https://academic.oup.com/mmy/advance-article/doi/10.1093/mmy
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http://dx.doi.org/10.1093/mmy/myy163DOI Listing
January 2019
3 Reads
2.335 Impact Factor

Unique clinical features of cryptococcal meningitis among Chinese patients without predisposing diseases against patients with predisposing diseases.

Med Mycol 2019 Jan 16. Epub 2019 Jan 16.

The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University. Qingchun Rd, Hangzhou, China.

The clinical features of cryptococcal meningitis (CM) in patients without predisposing diseases (PD) remain unclear. In sum, 162 of the 167 patients without PD and 162 of the 309 patients with PD were enrolled after propensity score matching. Demographic characteristics, symptoms, blood, and cerebrospinal fluid (CSF) characteristics were compared between the two groups. Read More

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http://dx.doi.org/10.1093/mmy/myy154DOI Listing
January 2019
1 Read
2.335 Impact Factor

Molecular types of Cryptococcus neoformans and Cryptococcus gattii in Western Australia and correlation with antifungal susceptibility.

Med Mycol 2019 Jan 15. Epub 2019 Jan 15.

Department of Microbiology, PathWest Laboratory Medicine WA, QEII Medical Centre, Hospital Avenue, Nedlands, Western Australia, 6009.

Cryptococcus neoformans and Cryptococcus gattii species complexes have a worldwide distribution; however, there is geographical variation in the prevalence of different molecular types. Additionally, antifungal susceptibility differences between molecular types have been demonstrated. This study investigates the distribution of cryptococcal molecular types among human clinical isolates over a 10-year period from a Western Australian population. Read More

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http://dx.doi.org/10.1093/mmy/myy161DOI Listing
January 2019
1 Read

Unequivocal identification of an underestimated opportunistic yeast species, Cyberlindnera fabianii, and its close relatives using a dual-function PCR and literature review of published cases.

Med Mycol 2019 Jan 12. Epub 2019 Jan 12.

Westerdijk Fungal Biodiversity Institute, Utrecht, the Netherlands.

Although Cyberlindnera fabinaii is a rare opportunist yeast species, its ability to cause septicemia, produce biofilm, and rapid acquisition of resistance to fluconazole and voriconazole, reinforced the urge for its identification from its closely related species. Widely used biochemical assays mainly identify Cyberlindnera fabinaii as Cyberlindnera jadinii and Wickerhamomyces anomalus, resulting in underestimation of this yeast in clinical settings. Moreover, the urge for a reliable molecular means of identification remains unsolved for 28 years. Read More

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http://dx.doi.org/10.1093/mmy/myy148DOI Listing
January 2019
8 Reads

Farnesol inhibits planktonic cells and antifungal-tolerant biofilms of Trichosporon asahii and Trichosporon inkin.

Med Mycol 2019 Jan 15. Epub 2019 Jan 15.

Faculty of Medicine, Post Graduate Program in Medical Microbiology, Federal University of Ceará, Brazil.

Trichosporon species have been considered important agents of opportunistic systemic infections, mainly among immunocompromised patients. Infections by Trichosporon spp. are generally associated with biofilm formation in invasive medical devices. Read More

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http://dx.doi.org/10.1093/mmy/myy160DOI Listing
January 2019

Species-specific detection of medically important aspergilli by a loop-mediated isothermal amplification method in chronic pulmonary aspergillosis.

Med Mycol 2019 Jan 12. Epub 2019 Jan 12.

Graduate School of Medicine, Teikyo University, Tokyo, Japan.

Chronic pulmonary aspergillosis (CPA) is a common subtype of pulmonary aspergillosis and a life-threatening disease. However, its diagnosis remains difficult due to the lack of specific clinical features and radiologic findings, as well as the difficulty of isolating Aspergillus spp. We developed a novel species-specific detection method of medically important aspergilli using a loop-mediated isothermal amplification (LAMP) for CPA. Read More

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http://dx.doi.org/10.1093/mmy/myy128DOI Listing
January 2019
2 Reads

Assessment of temperature-dependent proteomes of Pythium insidiosum by using the SWISS-PROT database.

Med Mycol 2019 Jan 15. Epub 2019 Jan 15.

Section of Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Pythium insidiosum causes the life-threatening disease, called pythiosis. Information on microbial pathogenesis could lead to an effective method of infection control. This study aims at assessing temperature-dependent proteomes, and identifying putative virulence factors of P. Read More

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https://academic.oup.com/mmy/advance-article/doi/10.1093/mmy
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http://dx.doi.org/10.1093/mmy/myy164DOI Listing
January 2019
2 Reads

Rapid and robust identification of clinical isolates of Talaromyces marneffei based on MALDI-TOF mass spectrometry or dimorphism in Galleria mellonella.

Med Mycol 2019 Jan 15. Epub 2019 Jan 15.

UK National Mycology Reference Laboratory (MRL), Public Health England South-West, Bristol, United Kingdom.

Talaromyces marneffei is a thermally dimorphic fungal pathogen that causes serious infections particularly in patients with human immunodeficiency virus (HIV). Although the mould form typically produces a characteristic red-diffusing pigment, and conidia from penicillate heads, several nonpathogenic Talaromyces/Penicillium species are morphologically and phenotypically similar. While those other species do not exhibit thermal dimorphism, conversion of T. Read More

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http://dx.doi.org/10.1093/mmy/myy162DOI Listing
January 2019

Novel canine anti-Coccidioides immunoglobulin G enzyme immunoassay aids in diagnosis of coccidioidomycosis in dogs.

Med Mycol 2019 Jan 12. Epub 2019 Jan 12.

MiraVista Diagnostics LLC. Indianapolis, Indiana, USA.

The diagnosis of coccidioidomycosis (CM) in dogs is typically based on clinical presentation, serology, and (less frequently) spherule identification. Agar gel immunodiffusion (AGID) is the most commonly employed serological method, but AGID is slow (requiring up to a week for titer). A Coccidioides antigen enzyme immunoassay (EIA) is also available; however, sensitivity is low in CM dogs. Read More

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http://dx.doi.org/10.1093/mmy/myy157DOI Listing
January 2019
1 Read

Prevalence of cryptococcal antigenemia and nasal colonization in a free-ranging koala population.

Med Mycol 2019 Jan 12. Epub 2019 Jan 12.

Sydney School of Veterinary Science, The University of Sydney, Sydney, New South Wales, Australia.

Cryptococcosis, caused by environmental fungi in the Cryptococcus neoformans and Cryptococcus gattii species complexes, affects a variety of hosts, including koalas (Phascolarctos cinereus). Cryptococcal antigenemia and nasal colonization are well characterized in captive koalas, but free-ranging populations have not been studied systematically. Free-ranging koalas (181) from the Liverpool Plains region of New South Wales, Australia, were tested for cryptococcal antigenemia (lateral flow immunoassay) and nasal colonization (bird seed agar culture). Read More

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http://dx.doi.org/10.1093/mmy/myy144DOI Listing
January 2019

Mating analyses of Trichophyton benhamiae offspring reveals linkage of genetic markers used in taxonomy.

Med Mycol 2019 Jan 9. Epub 2019 Jan 9.

Department of Dermatology, University Hospital Jena, Germany, Erfurter Str. 35 D-07743 Jena, Thuringia Germany.

Mating experiments were conducted with four clinical Trichophyton benhamiae isolates, genetically similar to the Trichophyton benhamiae CBS 112371, featuring the plus mating type and with two minus type strains. One minus type strain belonged to the white subgroup, and the other minus type strain, DSM 6916, showed genetic kinship to the yellow subgroup. Only two plus type strains were able to form mature, pigmented gymnothecia with DSM 6916. Read More

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http://dx.doi.org/10.1093/mmy/myy141DOI Listing
January 2019

In vitro anti-Pythium insidiosum activity of biogenic silver nanoparticles.

Med Mycol 2018 Dec 29. Epub 2018 Dec 29.

Departamento de Microbiologia e Parasitologia, Universidade Federal de Pelotas, Pelotas, RS, Brazil.

Pythium insidiosum belongs to the phylum Oomycota. It is capable of infecting mammals causing a serious condition called pythiosis, which affects mainly horses in Brazil and humans in Thailand. The objective of the present study was to verify the in vitro anti-P. Read More

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https://academic.oup.com/mmy/advance-article/doi/10.1093/mmy
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http://dx.doi.org/10.1093/mmy/myy147DOI Listing
December 2018
2 Reads

High diversity of Candida glabrata in a tertiary hospital-Mwanza, Tanzania.

Med Mycol 2018 Dec 29. Epub 2018 Dec 29.

Institute of Medical Microbiology, University Medical Center Gottingen, Germany.

Candida glabrata is a genetically diverse human pathogenic yeast, whose subpopulations have been documented to vary geographically. Here, we report MLST genotypes and antifungal drug susceptibility of C. glabrata isolates from Africa. Read More

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http://dx.doi.org/10.1093/mmy/myy151DOI Listing
December 2018

Development of a fully automated PCR assay for the detection of Pneumocystis jirovecii using the GENECUBE system.

Med Mycol 2018 Dec 26. Epub 2018 Dec 26.

Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

We developed a fully automated polymerase chain reaction (PCR) assay for the detection of Pneumocystis jirovecii using the GENECUBE system. This assay was evaluated against an in-house real-time PCR assay using 82 bronchoalveolar lavage and 139 sputum samples from 221 immunocompromised patients who were suspected of having Pneumocystis pneumonia (PCP). After loading the maximum of eight samples into the GENECUBE system, the results were obtained within approximately 60 minutes. Read More

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http://dx.doi.org/10.1093/mmy/myy145DOI Listing
December 2018
1 Read

The prevalence and clinical significance of microcolonies when tested according to contemporary interpretive breakpoints for fluconazole against Candida species using E-test.

Med Mycol 2018 Dec 21. Epub 2018 Dec 21.

Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Changes in the interpretive-breakpoints for antifungals against various Candida species have raised the need to examine the significance of the phenomenon of the growth of microcolonies in agar diffusion inhibition zones, which has generally been considered negligible. The objective was to determine the incidence of cases in which microcolonies demonstrate fluconazole resistance according to current interpretive-breakpoints and whether their growth is associated with therapeutic failure. The fluconazole minimum inhibitory concentrations (MICs) of 100 blood culture isolates of Candida were performed by E-test on Roswell Park Memorial Institute (RPMI) agar and examined for the appearance of microcolonies. Read More

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http://dx.doi.org/10.1093/mmy/myy130DOI Listing
December 2018

Molecular detection of Pneumocystis in the lungs of cats.

Med Mycol 2018 Dec 19. Epub 2018 Dec 19.

Centre for Veterinary Education, B22, University of Sydney, Sydney, New South Wales, Australia.

The genus Pneumocystis comprises potential pathogens that reside normally in the lungs of a wide range of mammals. Although they generally behave as transient or permanent commensals, they can occasionally cause life-threatening pneumonia (Pneumocystis pneumonia; PCP) in immunosuppressed individuals. Several decades ago, the presence of Pneumocystis morphotypes (trophic forms and cysts) was described in the lungs of normal cats and cats with experimentally induced symptomatic PCP (after immunosuppression by corticosteroids); yet to date spontaneous or drug-induced PCP has not been described in the clinical feline literature, despite immunosuppression of cats by long-standing retrovirus infections or after kidney transplantation. Read More

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http://dx.doi.org/10.1093/mmy/myy139DOI Listing
December 2018
1 Read

Potential clinical utility of ERC-2 yeast phase lysate antigen for antibody detection in dogs with blastomycosis.

Med Mycol 2018 Dec 12. Epub 2018 Dec 12.

Department of Biological Sciences, Idaho State University, Pocatello, Idaho, USA.

Four Blastomyces antigens ERC-2 (B. gilchristii, dog, Wisconsin), B5929 (human, Minnesota), 597 (human, Wisconsin), and T-27 (polar bear, Tennessee) were tested against 31 serum specimens from dogs with blastomycosis and 19 from healthy dogs. All antigens detected antibody; efficacy varied. Read More

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http://dx.doi.org/10.1093/mmy/myy137DOI Listing
December 2018
1 Read

Types of yeasts that cause vulvovaginal candidiasis in chronic users of corticosteroids.

Med Mycol 2018 Dec 12. Epub 2018 Dec 12.

Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt.

The current study aims to compare between the types of yeasts that cause vulvovaginal candidiasis (VVC) in women using corticosteroid medication compared to nonusers and estimate their sensitivity to available commercial antifungal agents. In a descriptive analytical cross-sectional study, we recruited 41 chronic corticosteroid users diagnosed clinically to have VVC from Women's Health Hospital, Assiut University, Egypt. Forty-seven age-matched women with VVC were recruited as a control group. Read More

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http://dx.doi.org/10.1093/mmy/myy117DOI Listing
December 2018
2.335 Impact Factor

Diagnostic accuracy of the 1,3-β-D-glucan test for pneumocystis pneumonia in a tertiary university hospital in Denmark: A retrospective study.

Med Mycol 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Microbiology, Copenhagen University Hospital Rigshospitalet, Denmark.

1,3-β-D-glucan (BG), a cell-wall component of most fungi including Pneumocystis (PC), is recommended by international guidelines for screening for pneumocystis pneumonia (PCP) in hematologic patients. We retrospectively validated the BG test in our tertiary university hospital. Forty-five patients (median age 53 years, 33% female) tested for PC by polymerase chain reaction (PCR) and/or immunoflourescence (IF)-microscopy with a stored blood sample within ±5 days of the PC test were tested by the Fungitell (cutoff <60 and >80 pg/ml). Read More

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http://dx.doi.org/10.1093/mmy/myy129DOI Listing
December 2018

Black aspergilli: A remaining challenge in fungal taxonomy?

Med Mycol 2018 Dec 11. Epub 2018 Dec 11.

BCCM/IHEM collection, Mycology and Aerobiology, Sciensano, J. Wytsmanstraat 14, 1050 Brussels, Belgium.

Aspergillus section Nigri is a taxonomically difficult but medically and economically important group. In this study, an update of the taxonomy of A. section Nigri strains within the BCCM/IHEM collection has been conducted. Read More

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http://dx.doi.org/10.1093/mmy/myy124DOI Listing
December 2018

Candida glabrata: Emerging pathogen of candiduria in hospitalized patients with heart disorders.

Med Mycol 2018 Dec 11. Epub 2018 Dec 11.

University of Brasília, Institute of Biological Sciences, BRASÍLIA, Brazil.

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http://dx.doi.org/10.1093/mmy/myy135DOI Listing
December 2018

An interferon gamma release assay specific for Histoplasma capsulatum to detect asymptomatic infected individuals: A proof of concept study.

Med Mycol 2018 Dec 11. Epub 2018 Dec 11.

Grupo de Micología Médica y Experimental, Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia.

Histoplasmosis is the most common endemic mycosis in the Americas. Currently, there is no laboratory test capable to detect subclinical or latent infections by Histoplasma capsulatum (Hc), which might develop as severe infections in immunocompromised individuals. For the first time to our knowledge, we explore the suitability of an interferon gamma release assay (IGRA) to detect latent Hc infection in asymptomatic individuals. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/mmy/myy131DOI Listing
December 2018
3 Reads

Effects of immune suppression in murine models of disseminated Candida glabrata and Candida tropicalis infection and utility of a synthetic peptide vaccine.

Authors:
Hong Xin

Med Mycol 2018 Dec 6. Epub 2018 Dec 6.

Louisiana State University Health Sciences Center, Microbiology and Immunology.

Candida species are the second most frequent cause of fungal infections worldwide. Current knowledge of immunity to Candida has been gleaned almost exclusively from studies on Candida albicans, the most common disease-causing species. Knowledge of immunity to non-albicans Candida (NAC) species is still at an early stage due to the lack of tractable animal models with which to study these important pathogens. Read More

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http://dx.doi.org/10.1093/mmy/myy122DOI Listing
December 2018
1 Read

Yeast-like filamentous fungi: Molecular identification and in vitro susceptibility study.

Med Mycol 2018 Dec 6. Epub 2018 Dec 6.

Department of Biomedical Sciences for Health, Università degli Studi di Milano.

Yeast-like filamentous fungi, collected in Italy from 1985 to 2018, were submitted to molecular identification and antifungal susceptibility testings. Clinical isolates were identified as Magnusiomyces capitatus (28), M. clavatus (18), and Geotrichum candidum (2). Read More

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http://dx.doi.org/10.1093/mmy/myy133DOI Listing
December 2018
2 Reads

Novel Paranannizziopsis species in a Wagler's viper (Tropidolaemus wagleri), tentacled snakes (Erpeton tentaculatum), and a rhinoceros snake (Rhynchophis boulengeri) in a zoological collection.

Med Mycol 2018 Dec 6. Epub 2018 Dec 6.

Mycology Unit, Facultat de Medicina i Ciències de la Salut and IISPV, University Rovira i Virgili, Reus, Spain.

We report several cases of fungal infections in snakes associated with a new species within the genus Paranannizziopsis. Three juvenile Wagler's vipers (Tropidolaemus wagleri) presented with skin abnormalities or ulcerative dermatitis, and two snakes died. Histologic examination of skin from the living viper revealed hyperplastic, hyperkeratotic, and crusting epidermitis with intralesional fungal elements. Read More

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http://dx.doi.org/10.1093/mmy/myy134DOI Listing
December 2018
13 Reads

Molecular detection of Blastomyces in an air sample from an outbreak associated residence.

Med Mycol 2018 Dec 3. Epub 2018 Dec 3.

Integrated Research and Development Laboratory, Marshfield Clinic Research Institute, Marshfield Clinic Health System, Marshfield, Wisconsin, USA.

Based on epidemiologic data during a blastomycosis outbreak, exposure within the home was suspected for two case patients that resided together. Soil and air samples were collected from the basement of their residence. Samples were tested for Blastomyces by culture and polymerase chain reaction (PCR) to compare with an available clinical isolate. Read More

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http://dx.doi.org/10.1093/mmy/myy085DOI Listing
December 2018
2 Reads

Identification of multiple species and subpopulations among Australian clinical Sporothrix isolates using whole genome sequencing.

Med Mycol 2018 Nov 30. Epub 2018 Nov 30.

PathWest Laboratory Medicine WA, Nedlands, WA, Australia.

Whole genome sequencing (WGS) was used to demonstrate the wide genetic variability within Sporothrix schenckii sensu lato and establish that there are two main species of Sporothrix within Australian clinical isolates-S. schenckii sensu stricto and Sporothrix globosa. We also demonstrated southwest Western Australia contained genetically similar S. Read More

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http://dx.doi.org/10.1093/mmy/myy126DOI Listing
November 2018
10 Reads

Risk factors for noncatheter-related Candida bloodstream infections in intensive care units: A multicenter case-control study.

Med Mycol 2018 Nov 28. Epub 2018 Nov 28.

Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.

Candida bloodstream infections are associated with high mortality among critically ill patients in intensive care units (ICUs). Studies that explore the risk factors for candidemia may support better patient care in intensive care units. We conducted a retrospective, multicenter case-control study to investigate the risk factors for noncatheter-related Candida bloodstream infections (CBSI) in adult ICUs. Read More

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http://dx.doi.org/10.1093/mmy/myy127DOI Listing
November 2018
1 Read