2,579 results match your criteria Medical Mycology [Journal]


An aero mycological analysis of Mucormycetes in indoor and outdoor environments of northern India.

Med Mycol 2019 Apr 13. Epub 2019 Apr 13.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Mucormycosis is an angio-invasive infection, predominantly acquired by inhalation of sporangiospores from the environment. However, the burden of Mucormycetes sporangiospores in the air is not well studied. We aimed to estimate the burden of Mucormycetes spores in the outdoor and indoor (hospital) environment across different seasons in north India. Read More

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http://dx.doi.org/10.1093/mmy/myz031DOI Listing

Screening of antibacterial drugs for antimicrobial activity against Pythium insidiosum.

Med Mycol 2019 Jun;57(4):523-525

Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil.

We tested 25 isolates of Pythium insidiosum to investigate their susceptibility to antibacterial drugs that act through inhibition of protein synthesis or other mechanisms of action. We observed that tetracycline, erythromycin, linezolid, nitrofurantoin, Synercid (quinupristin and dalfopristin), chloramphenicol, clindamycin, cetrimide, and crystal violet had inhibitory activity against P. insidiosum. Read More

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http://dx.doi.org/10.1093/mmy/myy056DOI Listing
June 2019
1 Read

Diagnostic usefulness of differential time to positivity in neutropenic cancer patients with suspected catheter-related candidemia.

Med Mycol 2019 Mar 30. Epub 2019 Mar 30.

Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Methods for distinguishing catheter-related candidemia (CRC) from non-CRC before catheter removal remain limited. We thus evaluated the diagnostic performance of differential time to positivity (DTP) to diagnose CRC in neutropenic cancer patients with suspected CRC. Of the 35 patients enrolled, 15 (43%) with CRC (six definite and nine probable) and 17 (49%) with non-CRC were finally analyzed. Read More

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http://dx.doi.org/10.1093/mmy/myz028DOI Listing
March 2019
1 Read

Development and evaluation of a real-time polymerase chain reaction for fast diagnosis of sporotrichosis caused by Sporothrix globosa.

Med Mycol 2019 Mar 30. Epub 2019 Mar 30.

National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory of Infectious Disease Prevention and Control, Beijing, China.

Sporothrix globosa is an important clinical pathogen in the Sporothrix complex, which is causing sporotrichosis. S. globosa is distributed worldwide, especially in Asia. Read More

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http://dx.doi.org/10.1093/mmy/myz029DOI Listing
March 2019
1 Read

Health care-associated invasive Candida infections in children.

Med Mycol 2019 Mar 20. Epub 2019 Mar 20.

Ondokuz Mayis University Faculty of Medicine, Department of Clinical Microbiology, 55139, Samsun, Turkey.

The aims of the study were to examine the distribution of Candida spp. isolated from sterile body sites, the antifungal susceptibility of the isolates to amphotericin B, and fluconazole, risk factors and clinical outcomes associated with invasive health care-associated Candida infections in neonates and children. Between January 2007 and January 2012, the patients with invasive candidiasis were detected from microbiology laboratary records and medical records were examined retrospectively. Read More

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http://dx.doi.org/10.1093/mmy/myz005DOI Listing
March 2019
3 Reads

Effect of non-antifungal agrochemicals on the pathogenic fungus Cryptococcus gattii.

Med Mycol 2019 Mar 19. Epub 2019 Mar 19.

Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.

The chemical control of pests and weeds is employed to improve crop production and the quality of agricultural products. The intensive use of pesticides, however, may cause environmental contamination, thus altering microbial communities. Cryptococcus gattii is an environmental yeast and the causative agent of cryptococcosis in both humans and animals. Read More

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http://dx.doi.org/10.1093/mmy/myz018DOI Listing

Posaconazole therapy in children with cystic fibrosis and Aspergillus-related lung disease.

Med Mycol 2019 Mar 16. Epub 2019 Mar 16.

Department of Respiratory Sciences, NIHR Biomedical Research Centre (Respiratory theme) and Institute for Lung Health, University of Leicester, Leicester, United Kingdom.

There is emerging evidence for the role of posaconazole in the management of Aspergillus-related cystic fibrosis (CF) lung disease. The tolerability and efficacy of posaconazole in paediatric CF is not well established. We report a prospective study over a fifty-three month period evaluating the safety, tolerability, and efficacy of posaconazole in pediatric CF. Read More

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http://dx.doi.org/10.1093/mmy/myz015DOI Listing
March 2019
1 Read
2.335 Impact Factor

Clinical and microbiological characteristics of paracoccidioidomycosis in patients with AIDS in Buenos Aires, Argentina.

Med Mycol 2019 Mar 15. Epub 2019 Mar 15.

Mycology Unit of the Infectious Diseases Hospital F.J. Muñiz, Reference Center of Mycology of Buenos Aires city, Argentina.

Paracoccidioidomycosis (Pm) is a systemic disease, endemic in the American continent. There are two different clinical forms, the infant-juvenile or subacute form (PmS) and the chronic adult form (PmC). The human immunodeficiency virus (HIV) associated paracoccidioidomycosis (PmHIV) shares characteristics with both of the previously mentioned forms. Read More

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http://dx.doi.org/10.1093/mmy/myz021DOI Listing
March 2019
1 Read

Candida isolates causing candidemia show different degrees of virulence in Galleria mellonella.

Med Mycol 2019 Mar 15. Epub 2019 Mar 15.

Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

We aim to assess intra- and interspecies differences in the virulence of Candida spp. strains causing candidemia using the invertebrate Galleria mellonella model. We studied 739 Candida spp. Read More

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http://dx.doi.org/10.1093/mmy/myz027DOI Listing
March 2019
1 Read

Candida auris colonization or infection of the ear: A single-center study in South Korea from 2016 to 2018.

Med Mycol 2019 Mar 15. Epub 2019 Mar 15.

Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Candida auris was first identified in Japan from specimens obtained from the ear, but most reports since have reported invasive infections or non-ear based cases. We reviewed all the microbiology records from a single center in South Korea from February 2016 to July 2018. One hundred eleven isolates were positive for C. Read More

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http://dx.doi.org/10.1093/mmy/myz020DOI Listing

β-citronellol alters cell surface properties of Candida albicans to influence pathogenicity related traits.

Med Mycol 2019 Mar 6. Epub 2019 Mar 6.

Medical Mycology Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi-110025, India.

The pathogenicity of Candida albicans, an opportunistic human fungal pathogen, is attributed to several virulence factors. β-citronellol is a monoterpenoid present in several plant essential oils. The present study explores the antifungal potential and mode of action of β-citronellol against C. Read More

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http://dx.doi.org/10.1093/mmy/myz009DOI Listing
March 2019
2 Reads
2.335 Impact Factor

Expression of ERG11 and efflux pump genes CDR1, CDR2 and SNQ2 in voriconazole susceptible and resistant Candida glabrata strains.

Med Mycol 2019 Mar 6. Epub 2019 Mar 6.

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, and Institut d'Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, Reus, Tarragona, Spain.

Candida glabrata causes difficult to treat invasive candidiasis due to its antifungal resistance, mainly to azoles. The aim of the present work was to study the role of the genes ERG11, CDR1, CDR2, and SNQ2 on the resistance to voriconazole (VRC) in a set of C. glabrata strains with known in vitro and in vivo susceptibility to this drug. Read More

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http://dx.doi.org/10.1093/mmy/myz014DOI Listing
March 2019
2 Reads

Ochratoxin A suppresses proliferation of Sertoli and Leydig cells in mice.

Med Mycol 2019 Mar 6. Epub 2019 Mar 6.

Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.

Ochratoxin A (OTA) is a mycotoxin originating from Penicillium and Aspergillus. In addition to toxic effects in various tissues and cells, including neurons, immune cells, hepatocytes, and nephrons, it also causes carcinogenesis and teratogenesis. Although the negative effects of OTA with respect to the pathogenesis of diseases and the malfunction of various organs have been studied widely, the biological signaling mechanisms in testicular cells are less well known. Read More

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http://dx.doi.org/10.1093/mmy/myz016DOI Listing

Clinical value of (1,3)-β-D-glucan, mannan, antimannan IgG and IgM antibodies in diagnosis of invasive candidiasis.

Med Mycol 2019 Mar 1. Epub 2019 Mar 1.

Center for Clinical Laboratory Medicine, PLA General Hospital, Beijing, China.

Diagnosis of invasive candidiasis (IC) is still challenging due to absence of specific clinical signs and symptoms. In this study we investigate the clinical value of (1,3)-β-D-glucan (BDG), mannan (MN), antimannan immunoglobulin G (AM-IgG), and antimannan immunoglobulin M (AM-IgM) assay in diagnosis of IC. During 2016 to 2018 serum samples from 71 patients with IC and 185 patients without IC were collected. Read More

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http://dx.doi.org/10.1093/mmy/myy158DOI Listing

Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors.

Med Mycol 2019 Apr;57(Supplement_2):S245-S256

Jena Microbial Resource Collection, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Adolf-Reichwein-Strasse 23, 07745 Jena, Germany.

Fungi of the basal lineage order Mucorales are able to cause infections in animals and humans. Mucormycosis is a well-known, life-threatening disease especially in patients with a compromised immune system. The rate of mortality and morbidity caused by mucormycosis has increased rapidly during the last decades, especially in developing countries. Read More

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http://dx.doi.org/10.1093/mmy/myz011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394756PMC
April 2019
3 Reads

Breakthrough invasive fungal diseases in acute myeloid leukemia patients receiving mould active triazole primary prophylaxis after intensive chemotherapy: An Italian consensus agreement on definitions and management.

Med Mycol 2019 Apr;57(Supplement_2):S127-S137

Haematology and BMT Unit, University of Parma, Parma, Italy.

In the attempt to establish definitions and provide shared approaches to breakthrough invasive fungal diseases (br-IFD) in acute myeloid leukemia (AML) patients submitted to intensive chemotherapy and receiving triazoles as mould active primary antifungal prophylaxis (MA-PAP), literature on br-IFD in AML patients receiving triazoles MA-PAP was reviewed and a Consensus Development Conference Project was convened. The following four candidate key-questions were generated and formed the set of questions of the present document: "definition of br-IFD," "diagnostic strategy during MA-PAP to detect br-IFD," "possible causes of MA-PAP failure," "management of br-IFD." Read More

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http://dx.doi.org/10.1093/mmy/myy091DOI Listing

The human lung and Aspergillus: You are what you breathe in?

Med Mycol 2019 Apr;57(Supplement_2):S145-S154

Nacional Institute of Health Dr. Ricardo Jorge - URSZ- Infectious Diseases Department, Lisbon, Portugal.

The diversity of fungal species comprising the lung mycobiome is a reflection of exposure to environmental and endogenous filamentous fungi and yeasts. Most lung mycobiome studies have been culture-based. A few have utilized next generation sequencing (NGS). Read More

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http://dx.doi.org/10.1093/mmy/myy149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394755PMC
April 2019
2 Reads

Contrasts between mucormycosis and aspergillosis in oncohematological patients.

Med Mycol 2019 Apr;57(Supplement_2):S138-S144

I.P.Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo str., Saint Petersburg, Russian Federation, 197022.

In retrospective multicenter study from years 2007-2017, we evaluated 59 oncohematological patients with mucormycosis and 541 with invasive aspergillosis (IA). Mucormycosis developed more often in children and adolescents (P = .001), as well as after the emergence of graft versus host disease (P = . Read More

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http://dx.doi.org/10.1093/mmy/myy116DOI Listing
April 2019
6 Reads

Aspergillus colonization and antifungal immunity in cystic fibrosis patients.

Med Mycol 2019 Apr;57(Supplement_2):S118-S126

National Heart and Lung Institute, Imperial College London, United Kingdom.

Cystic fibrosis (CF), caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, is the most common inherited life-limiting disease in North European people affecting 90,000 people worldwide. Progressive lung damage caused by recurrent infection and chronic airway inflammation is the major determinant of survival with a median age at death of 29 years. Approximately 60% of CF patients are infected with Aspergillus fumigatus, a ubiquitous environmental fungus, and its presence has been associated with accelerated lung function decline. Read More

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http://dx.doi.org/10.1093/mmy/myy074DOI Listing
April 2019
1 Read

Chronic pulmonary aspergillosis update: A year in review.

Med Mycol 2019 Apr;57(Supplement_2):S104-S109

Department of Pulmonary Medicine, Kepler University Hospital, Linz, Austria.

Chronic pulmonary aspergillosis (CPA) is an uncommon, slowly destructive pulmonary disease characterized by progressive cavitation, fibrosis, and pleural thickening. CPA is usually seen in immunocompetent individuals with underlying respiratory disorders. Estimates suggest that up to 3 million people are affected worldwide causing high rates of morbidity and mortality. Read More

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http://dx.doi.org/10.1093/mmy/myy070DOI Listing
April 2019
4 Reads

Challenging cases in fungal asthma.

Med Mycol 2019 Apr;57(Supplement_2):S110-S117

Professor Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Fungal asthma broadly encompasses the presence of fungal sensitization or fungal allergy in patients with asthma. The clinical presentation of fungal asthma can vary from fungal-sensitized asthma at one end to allergic bronchopulmonary mycosis at the other end of the spectrum. Here we present five cases that illustrate some of the most challenging aspects of the diagnosis and management of fungal asthma. Read More

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http://dx.doi.org/10.1093/mmy/myy063DOI Listing
April 2019
9 Reads

Aspergillus-Pseudomonas interaction, relevant to competition in airways.

Med Mycol 2019 Apr;57(Supplement_2):S228-S232

California Institute for Medical Research, San Jose, California, USA.

In airways of immunocompromised patients and individuals with cystic fibrosis, Pseudomonas aeruginosa and Aspergillus fumigatus are the most common opportunistic bacterial and fungal pathogens. Both pathogens form biofilms and cause acute and chronic illnesses. Previous studies revealed that P. Read More

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http://dx.doi.org/10.1093/mmy/myy087DOI Listing
April 2019
2 Reads

Learning to control tissue damage while fighting Aspergillus.

Med Mycol 2019 Apr;57(Supplement_2):S189-S195

Department of Experimental Medicine, University of Perugia, Perugia, Italy.

Aspergillus moulds are increasingly being recognised as significant human pathogens that can cause life-threatening infections in the context of host immune dysregulation, particularly in the lung. It is now clear that there is a close relationship between infection susceptibility and the fine regulation of pulmonary immunity and inflammation. While the contribution of IL-17/Th17 responses to both physiological and pathological lung inflammation is now well established, the cellular interactions, soluble factors, and signalling pathways that determine Th17 cell responses to fungal infection remain unclear. Read More

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http://dx.doi.org/10.1093/mmy/myy053DOI Listing
April 2019
1 Read

Mycovirus therapy for invasive pulmonary aspergillosis?

Med Mycol 2019 Apr;57(Supplement_2):S179-S188

ErasmusMC, Department of Medical Microbiology and Infectious Diseases, Wytemaweg 80, 3015 CE Rotterdam, The Netherlands.

With the current revived interest in the use of bacteriophages for the treatment of bacterial infections, the study of mycoviruses as novel therapeutic solutions for invasive aspergillosis is the logical next step. Although ssRNA, dsRNA, and ssDNA mycoviruses have been identified, the majority of characterised mycoviruses have dsRNA genomes. Prevalence of dsRNA mycoviruses in Aspergillus spp. Read More

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http://dx.doi.org/10.1093/mmy/myy073DOI Listing
April 2019
2 Reads

The role of occupational Aspergillus exposure in the development of diseases.

Med Mycol 2019 Apr;57(Supplement_2):S196-S205

Mycology Reference Centre, Manchester University NHS Foundation Trust.

Aspergillus spp. have a high nutritional versatility and good growth on a large variety of construction materials. They also colonize soil or food, but decaying vegetation is their primary ecological niche. Read More

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https://academic.oup.com/mmy/article/57/Supplement_2/S196/53
Publisher Site
http://dx.doi.org/10.1093/mmy/myy090DOI Listing
April 2019
7 Reads

Integration of electron microscopy and solid-state NMR analysis for new views and compositional parameters of Aspergillus fumigatus biofilms.

Med Mycol 2019 Apr;57(Supplement_2):S239-S244

Department of Chemistry, Stanford University, Stanford, California USA.

The general ability and tendency of bacteria and fungi to assemble into bacterial communities, termed biofilms, poses unique challenges to the treatment of human infections. Fungal biofilms, in particular, are associated with enhanced virulence in vivo and decreased sensitivity to antifungals. Much attention has been given to the complex cell wall structures in fungal organisms, yet beyond the cell surface, Aspergillus fumigatus and other fungi assemble a self-secreted extracellular matrix that is the hallmark of the biofilm lifestyle, protecting and changing the environment of resident members. Read More

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http://dx.doi.org/10.1093/mmy/myy140DOI Listing
April 2019
3 Reads
2.335 Impact Factor

Beyond tissue concentrations: antifungal penetration at the site of infection.

Med Mycol 2019 Apr;57(Supplement_2):S161-S167

Public Health Research Institute, New Jersey Medical School-Rutgers Biomedical and Health Sciences, Newark, NJ 07103.

Despite advances in antifungal therapy, invasive fungal infections remain a significant cause of morbidity and mortality worldwide. One important factor contributing to the relative ineffectiveness of existing antifungal drugs is insufficient drug exposure at the site of infection. Despite the importance of this aspect of antifungal therapy, we generally lack a full appreciation of how antifungal drugs distribute, penetrate, and interact with their target organisms in different tissue subcompartments. Read More

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http://dx.doi.org/10.1093/mmy/myy067DOI Listing
April 2019
2.335 Impact Factor

Broad spectrum triazoles for invasive mould infections in adults: Which drug and when?

Med Mycol 2019 Apr;57(Supplement_2):S168-S178

Division of Infectious Diseases, Department of Medicine, University of California-San Diego, San Diego, California, USA.

Invasive mould infections are an increasing cause of morbidity and mortality globally, mainly due to increasing numbers of immunocompromised individuals at risk for fungal infections. The introduction of broad spectrum triazoles, which are much better tolerated compared to conventional amphotericin B formulations, has increased survival, particularly in invasive mould infection. However, early initiation of appropriate antifungal treatment remains a major predictor of outcome in invasive mould infection, but despite significant advances in diagnosis of these diseases, early diagnosis remains a challenge. Read More

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http://dx.doi.org/10.1093/mmy/myy052DOI Listing
April 2019
3 Reads

Genetic defects in fungal recognition and susceptibility to invasive pulmonary aspergillosis.

Med Mycol 2019 Apr;57(Supplement_2):S211-S218

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.

The interindividual variability in the onset and clinical course of invasive pulmonary aspergillosis (IPA) raises fundamental questions about its actual pathogenesis. Clinical and epidemiological studies have reported only a few examples of monogenic defects, however an expanding number of common polymorphisms associated with IPA has been identified. Understanding how genetic variation regulates the immune response to Aspergillus provides critical insights into the human immunobiology of IPA by pinpointing directly relevant immune molecules and interacting pathways. Read More

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http://dx.doi.org/10.1093/mmy/myy057DOI Listing
April 2019
2 Reads

How to make a fast diagnosis in invasive aspergillosis.

Med Mycol 2019 Apr;57(Supplement_2):S155-S160

Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstraße 41, 6020 Innsbruck/Austria.

Aspergillosis is more common among immunocompromised patients with neutropenia or immunosuppression due to corticosteroid use, and infections are typically of the lung or sinuses. For diagnosis, broncholaveolar lavages (BALs) and lung biopsies are the specimens of choice. Culture and microscopic examinations are a must have and laboratory results should immediately be reported to the clinic. Read More

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http://dx.doi.org/10.1093/mmy/myy103DOI Listing
April 2019
1 Read

Calcium signaling pathway is involved in non-CYP51 azole resistance in Aspergillus fumigatus.

Med Mycol 2019 Apr;57(Supplement_2):S233-S238

Jiangsu Key laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.

The opportunistic fungal pathogen Aspergillus fumigatus, which is one of the primary airborne ascomycete pathogens and allergens worldwide, causes invasive fungal infections, which have high morbidity and mortality rates among immunosuppressed patients. The abuse of azole antifungals results in serious drug resistance in clinical therapy. Thus, a thorough understanding of the azole drug resistance mechanism and screening of antifungal agents with a novel mode of action and new drug targets are required to fight against drug resistance. Read More

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http://dx.doi.org/10.1093/mmy/myy075DOI Listing

Why are so many cases of invasive aspergillosis missed?

Med Mycol 2019 Apr;57(Supplement_2):S94-S103

Department of Infectious Diseases and Tropical Medicine, Necker-Pasteur Infectious Diseases Center, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Institut Imagine, Paris Descartes University, Paris, France.

Invasive aspergillosis (IA) incidence is increasing in several countries like France, and numerous cases are indeed missed and still only diagnosed at autopsy as evidenced by recently published data. Such missed diagnoses are obviously encountered when appropriate diagnostic tools are not available especially in low resource areas or when biologists have not been trained enough in medical mycology (i.e. Read More

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https://academic.oup.com/mmy/article/57/Supplement_2/S94/536
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http://dx.doi.org/10.1093/mmy/myy081DOI Listing
April 2019
8 Reads
2.335 Impact Factor

Why are natural killer cells important for defense against Aspergillus?

Med Mycol 2019 Apr;57(Supplement_2):S206-S210

Division of Pediatric Hematology and Oncology, Hospital for Children and Adolescents, Johann Wolfgang Goethe-University, Frankfurt, Germany.

There is growing evidence that natural killer (NK) cells play an important role in the host response to Aspergillus spp. In vitro data clearly demonstrate that both murine and human NK cells are able to damage Aspergillus. NK cells exert direct antifungal activity via cytotoxic molecules such as perforin, and NK cell-derived cytokines and interferons modulate proliferation and activation of a variety of immune cells in order to fight the fungus. Read More

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http://dx.doi.org/10.1093/mmy/myy034DOI Listing

The 8th Advances Against Aspergillosis (AAA) conference.

Authors:

Med Mycol 2019 Apr;57(Supplement_2):S93

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http://dx.doi.org/10.1093/mmy/myy142DOI Listing
April 2019
2 Reads

An interferon gamma release assay specific for Histoplasma capsulatum to detect asymptomatic infected individuals: A proof of concept study.

Med Mycol 2019 Feb 28. Epub 2019 Feb 28.

Grupo de Micología Médica y Experimental, Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia.

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http://dx.doi.org/10.1093/mmy/myz022DOI Listing
February 2019
1 Read

Clinical outcomes in ocular pythiosis patients treated with a combination therapy protocol in Thailand: A prospective study.

Med Mycol 2019 Feb 26. Epub 2019 Feb 26.

Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Ocular pythiosis is the second most common form of human pythiosis, and the rates of evisceration/enucleation in Thailand are 55-79%. This prospective study was conducted to evaluate treatment outcomes of the combination therapy protocol and the potential use of serum (1→3)-β-glucan (BG) and Pythium insidiosum-specific antibody (Pi-Ab) as an aid to diagnosis and monitoring of ocular pythiosis. Thirty patients were enrolled in the study and 14 (non-globe salvage) required evisceration/enucleation. Read More

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http://dx.doi.org/10.1093/mmy/myz013DOI Listing
February 2019
2 Reads

Impact of dose adaptations following voriconazole therapeutic drug monitoring in pediatric patients.

Med Mycol 2019 Feb 13. Epub 2019 Feb 13.

Radboud university medical center, Department of Pharmacy and Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

Voriconazole is the mainstay of treatment for invasive aspergillosis in immunocompromised pediatric patients. Although Therapeutic Drug Monitoring (TDM) of voriconazole is recommended, it remains unknown if TDM-based dose adaptations result in target attainment. Patients <19 years from two pediatric hematologic-oncology wards were retrospectively identified based on unexplained high voriconazole trough concentrations (Cmin > 6 mg/l). Read More

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http://dx.doi.org/10.1093/mmy/myz006DOI Listing
February 2019
1 Read

Increased virulence of albino mutant of Fonsecaea monophora in Galleria mellonella.

Med Mycol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biological Sciences, Youngstown State University, One University Plaza, Youngstown, OH, USA.

Fonsecaea monophora has been the predominant pathogen of chromoblastomycosis in Southern China, but its pathogenic mechanism remains unclear. New models are needed to study this infection. In the current study, we examined the role of melanin on the pathogenicity of F. Read More

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http://dx.doi.org/10.1093/mmy/myz007DOI Listing
February 2019

The serine peptidase inhibitor TPCK induces several morphophysiological changes in the opportunistic fungal pathogen Candida parapsilosis sensu stricto.

Med Mycol 2019 Feb 9. Epub 2019 Feb 9.

Laboratório de Estudos Avançados de Microrganismos Emergentes e Resistentes, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Candida parapsilosis sensu stricto (C. parapsilosis) has emerged as the second/third commonest Candida species isolated from hospitals worldwide. Candida spp. Read More

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http://dx.doi.org/10.1093/mmy/myz008DOI Listing
February 2019
1 Read

Experimental Candida albicans osteomyelitis: Microbiologic, antigenic, histologic, and 18FDG-PET-CT imaging characteristics in a newly established rabbit model.

Med Mycol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Candida osteomyelitis is a debilitating disease that is difficult to diagnose and treat. As there are no animal models or prospective studies for this uncommon infection, little is known about the pathogenesis, diagnosis, or treatment. We therefore sought to establish an animal model for the study of the pathophysiology, diagnostic modalities, and therapeutic interventions of Candida osteomyelitis. Read More

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http://dx.doi.org/10.1093/mmy/myz001DOI Listing
February 2019
2 Reads

Use of Aspergillus fumigatus real-time PCR in bronchoalveolar lavage samples (BAL) for diagnosis of invasive aspergillosis, including azole-resistant cases, in high risk haematology patients: the need for a combined use with galactomannan.

Med Mycol 2019 Feb 7. Epub 2019 Feb 7.

Division of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.

Diagnosis of invasive aspergillosis (IA) is challenging, particularly in high-risk patients with lung lesions other than typical according to 2008-EORTC/MSG criteria. Even if microbiology is positive, they still remain unclassified according to 2008-EORTC/MSG. Quantitative polymerase chain reaction (qPCR) provides new mycological documentation of IA. Read More

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http://dx.doi.org/10.1093/mmy/myz002DOI Listing
February 2019
2 Reads

Coccidioidomycosis: What a long strange trip it's been.

Med Mycol 2019 Feb;57(Supplement_1):S3-S15

California Institute for Medical Research, San Jose, California, USA.

The recorded history of coccidioidomycosis began in 1892 with the report of the illness of Domingo Escurra by Alejandro Posadas followed by a description of the first North American cases by Rixford and Gilchrist. Originally considered a protozoan, William Ophüls determined that Coccidioides was a fungus and that the lungs were the apparent initial site of infection. During the 1930s, both Gifford and Dickson determined that a self-limited illness, Valley Fever, was caused by the same fungus that caused the often fatal coccidioidal granuloma. Read More

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http://dx.doi.org/10.1093/mmy/myy123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347081PMC
February 2019
3 Reads

Coccidioides ecology and genomics.

Med Mycol 2019 Feb;57(Supplement_1):S21-S29

Department of Microbiology, Centro de Investigación Científica y Educación Superior de Ensenada (CICESE), Ctra. Ensenada-Tijuana No. 3918, Ensenada, Baja California, 22860, Mexico.

Although the natural history and ecology of Coccidioides spp. have been studied for over 100 years, many fundamental questions about this fungus remain unanswered. Two of the most challenging aspects of the study of Coccidioides have been the undefined ecological niche and the outdated geographic distribution maps dating from midcentury. Read More

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http://dx.doi.org/10.1093/mmy/myy051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347077PMC
February 2019
6 Reads
2.335 Impact Factor

The endozoan, small-mammal reservoir hypothesis and the life cycle of Coccidioides species.

Med Mycol 2019 Feb;57(Supplement_1):S16-S20

Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.

The prevailing hypothesis concerning the ecology of Coccidioides immitis and C. posadasii is that these human pathogenic fungi are soil fungi endemic to hot, dry, salty regions of the New World and that humans and the local, small-mammal fauna are only accidental hosts. Here we advance an alternative hypothesis that Coccidioides spp. Read More

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https://academic.oup.com/mmy/article/57/Supplement_1/S16/530
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http://dx.doi.org/10.1093/mmy/myy039DOI Listing
February 2019
10 Reads
2.335 Impact Factor

A review of innate and adaptive immunity to coccidioidomycosis.

Med Mycol 2019 Feb;57(Supplement_1):S85-S92

Infectious Diseases Section, VA Healthcare San Diego, California, USA.

Coccidioidomycosis is a human fungal disease cause by inhalation of aerosol spores produced by Coccidioides posadasii or Coccidioides immitis. This disease is a common cause of community-acquired pneumonia in the endemic areas of the Southwestern United States. It also can present as a life-threatening disease as the fungal cells disseminate to skin, bone, and central nervous system. Read More

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http://dx.doi.org/10.1093/mmy/myy146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347076PMC
February 2019
7 Reads

Current Concepts and Future Directions in the Pharmacology and Treatment of Coccidioidomycosis.

Med Mycol 2019 Feb;57(Supplement_1):S76-S84

Division of Infectious Diseases, UT Health San Antonio, and the South Texas Veterans Health Care System; San Antonio, Texas, USA.

Coccidioidomycosis remains a significant clinical problem with substantial morbidity and mortality. The vast majority of infections are asymptomatic and the need for early primary therapy remains controversial. The use of triazole antifungals has improved tolerability of therapy but concerns about acute and long-term toxicities among available agents limit their use. Read More

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https://academic.oup.com/mmy/article/57/Supplement_1/S76/530
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http://dx.doi.org/10.1093/mmy/myy029DOI Listing
February 2019
21 Reads

Selected Clinical Features of Coccidioidomycosis in Dogs.

Med Mycol 2019 Feb;57(Supplement_1):S67-S75

School of Veterinary Medicine, University of California-Davis, Davis, California, USA.

Canine coccidioidomycosis, a systemic fungal infection endemic to arid and semiarid regions of North, Central, and South America, is commonly diagnosed in dogs living in or traveling through lower Sonoran life zones in the states of California and Arizona. Canine and human cases have geographic overlap. Similarities between clinical coccidioidomycosis in dogs and humans include asymptomatic infection, primary respiratory disease and disseminated disease. Read More

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https://academic.oup.com/mmy/article/57/Supplement_1/S67/530
Publisher Site
http://dx.doi.org/10.1093/mmy/myy113DOI Listing
February 2019
9 Reads