13,426 results match your criteria Medical Informatics in Neurology


Plasma biomarkers of brain injury in COVID-19 patients with neurological symptoms.

J Neurol Sci 2022 Jun 17;439:120324. Epub 2022 Jun 17.

Kirsehir Ahi Evran University Faculty of Medicine, Department of Clinical Microbiology and Infectious Diseases, Kirsehir, Turkey.

Objective: Neurological symptoms (NS) were often reported in COVID-19 infection. We examined the plasma levels of glial fibrillary acidic protein (GFAP) and S100B together, as brain injury biomarkers, in relation to persistent NS in a cohort of patients with COVID-19 during the acute phase of the disease.

Methods: A total of 20 healthy controls and 58 patients with confirmed COVID-19 were enrolled in this prospective study. Read More

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Multi-centre classification of functional neurological disorders based on resting-state functional connectivity.

Neuroimage Clin 2022 Jun 17;35:103090. Epub 2022 Jun 17.

Psychosomatic Medicine, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland. Electronic address:

Background: Patients suffering from functional neurological disorder (FND) experience disabling neurological symptoms not caused by an underlying classical neurological disease (such as stroke or multiple sclerosis). The diagnosis is made based on reliable positive clinical signs, but clinicians often require additional time- and cost consuming medical tests and examinations. Resting-state functional connectivity (RS FC) showed its potential as an imaging-based adjunctive biomarker to help distinguish patients from healthy controls and could represent a "rule-in" procedure to assist in the diagnostic process. Read More

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Classifying unstructured electronic consult messages to understand primary care physician specialty information needs.

J Am Med Inform Assoc 2022 Jun 25. Epub 2022 Jun 25.

Computational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts, USA.

Objective: Electronic consultation (eConsult) content reflects important information about referring clinician needs across an organization, but is challenging to extract. The objective of this work was to develop machine learning models for classifying eConsult questions for question type and question content. Another objective of this work was to investigate the ability to solve this task with constrained expert time resources. Read More

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Calculating genetic risk for dysfunction in pleiotropic biological processes using whole exome sequencing data.

J Neurodev Disord 2022 Jun 24;14(1):39. Epub 2022 Jun 24.

Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: Numerous genes are implicated in autism spectrum disorder (ASD). ASD encompasses a wide-range and severity of symptoms and co-occurring conditions; however, the details of how genetic variation contributes to phenotypic differences are unclear. This creates a challenge for translating genetic evidence into clinically useful knowledge. Read More

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Predicting Shunt Dependency from the Effect of Cerebrospinal Fluid Drainage on Ventricular Size.

Neurocrit Care 2022 Jun 25. Epub 2022 Jun 25.

Department of Neurology, Columbia University, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA.

Background: Prolonged external ventricular drainage (EVD) in patients with subarachnoid hemorrhage (SAH) leads to morbidity, whereas early removal can have untoward effects related to recurrent hydrocephalus. A metric to help determine the optimal time for EVD removal or ventriculoperitoneal shunt (VPS) placement would be beneficial in preventing the prolonged, unnecessary use of EVD. This study aimed to identify whether dynamics of cerebrospinal fluid (CSF) biometrics can temporally predict VPS dependency after SAH. Read More

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Neurofilament light chain: a new marker for neuronal decay in the anterior chamber fluid of patients with glaucoma.

Br J Ophthalmol 2022 Jun 24. Epub 2022 Jun 24.

Department of Ophthalmology, Medical University of Graz, Graz, Austria

Background/aims: Neurofilament light chain (NfL) levels in cerebrospinal fluid and serum are reliable indicators for neuroaxonal damage in a broad spectrum of neurodegenerative diseases. Herein, we investigate NfL levels in serum and anterior chamber fluid of patients with glaucoma.

Methods: Patients scheduled for routine glaucoma or cataract surgery were recruited for this study. Read More

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Prediction of White Matter Hyperintensity in Brain MRI Using Fundus Photographs via Deep Learning.

J Clin Med 2022 Jun 9;11(12). Epub 2022 Jun 9.

Department of Neurology, Chuncheon Sacred Heart Hospital, Chuncheon 24253, Korea.

Purpose: We investigated whether a deep learning algorithm applied to retinal fundoscopic images could predict cerebral white matter hyperintensity (WMH), as represented by a modified Fazekas scale (FS), on brain magnetic resonance imaging (MRI).

Methods: Participants who had undergone brain MRI and health-screening fundus photography at Hallym University Sacred Heart Hospital between 2010 and 2020 were consecutively included. The subjects were divided based on the presence of WMH, then classified into three groups according to the FS grade (0 vs. Read More

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Deep-Learning-Based Thrombus Localization and Segmentation in Patients with Posterior Circulation Stroke.

Diagnostics (Basel) 2022 Jun 6;12(6). Epub 2022 Jun 6.

Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, Location AMC, 1105 AZ Amsterdam, The Netherlands.

Thrombus volume in posterior circulation stroke (PCS) has been associated with outcome, through recanalization. Manual thrombus segmentation is impractical for large scale analysis of image characteristics. Hence, in this study we develop the first automatic method for thrombus localization and segmentation on CT in patients with PCS. Read More

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Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals.

Mol Psychiatry 2022 Jun 14. Epub 2022 Jun 14.

National Institute of Mental Health, Klecany, Czech Republic.

Schizophrenia is frequently associated with obesity, which is linked with neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto the brain changes in schizophrenia. We obtained MRI-derived brain cortical and subcortical measures and body mass index (BMI) from 1260 individuals with schizophrenia and 1761 controls from 12 independent research sites within the ENIGMA-Schizophrenia Working Group. Read More

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Changes in laboratory value improvement and mortality rates over the course of the pandemic: an international retrospective cohort study of hospitalised patients infected with SARS-CoV-2.

BMJ Open 2022 Jun 23;12(6):e057725. Epub 2022 Jun 23.

Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Objective: To assess changes in international mortality rates and laboratory recovery rates during hospitalisation for patients hospitalised with SARS-CoV-2 between the first wave (1 March to 30 June 2020) and the second wave (1 July 2020 to 31 January 2021) of the COVID-19 pandemic.

Design, Setting And Participants: This is a retrospective cohort study of 83 178 hospitalised patients admitted between 7 days before or 14 days after PCR-confirmed SARS-CoV-2 infection within the Consortium for Clinical Characterization of COVID-19 by Electronic Health Record, an international multihealthcare system collaborative of 288 hospitals in the USA and Europe. The laboratory recovery rates and mortality rates over time were compared between the two waves of the pandemic. Read More

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Brain age as a surrogate marker for cognitive performance in multiple sclerosis.

Eur J Neurol 2022 Jun 23. Epub 2022 Jun 23.

AIMS lab, Center for Neurosciences, UZ Brussel, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium.

Background: Data from neuro-imaging techniques allow us to estimate a brain's age. Brain age is easily interpretable as "how old the brain looks", and could therefore be an attractive communication tool for brain health in clinical practice. This study aimed to investigate its clinical utility by investigating the relationship between brain age and cognitive performance in multiple sclerosis (MS). Read More

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Snotwatch: an ecological analysis of the relationship between febrile seizures and respiratory virus activity.

BMC Pediatr 2022 Jun 22;22(1):359. Epub 2022 Jun 22.

Department of Paediatrics, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.

Background: Febrile seizures are the commonest type of seizure in occurring in the first few years of life, mostly affecting children aged six months to five years old. While largely benign, the incidence of each febrile seizure increases the risk of recurrence, afebrile seizures and epilepsy. Viruses are the most frequent cause of febrile illnesses in which a febrile seizure occurs. Read More

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A study to investigate the prevalence of headache disorders and migraine among people registered in a health insurance association in Japan.

J Headache Pain 2022 Jun 23;23(1):70. Epub 2022 Jun 23.

Medical Affairs, Otsuka Pharmaceutical Co., Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima, 771-0192, Japan.

Background: Migraine is a chronic disease characterized by episodic headache attacks. No recent studies have, however been conducted on the epidemiology of migraine or the treatment landscape in Japan. This study was conducted as a fact-finding survey using medical claims data and an online survey on migraine and headaches, conducted among members of health insurance associations with the objective of gaining an understanding of migraine prevalence and the treatment status in Japan. Read More

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Automated analysis of low-field brain MRI in cerebral malaria.

Biometrics 2022 Jun 22. Epub 2022 Jun 22.

The Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania.

A central challenge of medical imaging studies is to extract biomarkers that characterize disease pathology or outcomes. Modern automated approaches have found tremendous success in high-resolution, high-quality magnetic resonance images (MRI). These methods, however, may not translate to low-resolution images acquired on MRI scanners with lower magnetic field strength. Read More

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Voxel-wise intermodal coupling analysis of two or more modalities using local covariance decomposition.

Hum Brain Mapp 2022 Jun 22. Epub 2022 Jun 22.

Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

When individual subjects are imaged with multiple modalities, biological information is present not only within each modality, but also between modalities - that is, in how modalities covary at the voxel level. Previous studies have shown that local covariance structures between modalities, or intermodal coupling (IMCo), can be summarized for two modalities, and that two-modality IMCo reveals otherwise undiscovered patterns in neurodevelopment and certain diseases. However, previous IMCo methods are based on the slopes of local weighted linear regression lines, which are inherently asymmetric and limited to the two-modality setting. Read More

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Persistent Dissociation and Its Neural Correlates in Predicting Outcomes After Trauma Exposure.

Am J Psychiatry 2022 Jun 22:appiajp21090911. Epub 2022 Jun 22.

Division of Depression and Anxiety Disorders (Lebois, Harnett, Ravichandran, Dumornay, Finegold, Merker, Pizzagalli, Ressler), Institute for Technology in Psychiatry (Germine, Rauch), and Department of Psychiatry (Rauch), McLean Hospital, Belmont, Mass.; Department of Psychiatry (Lebois, Harnett, Ravichandran, Germine, Rauch, Pizzagalli, Ressler), Department of Emergency Medicine (Sanchez), and Department of Health Care Policy (Kessler), Harvard Medical School, Boston; Department of Psychiatry and Behavioral Sciences (van Rooij, Ely, Stevens), Department of Biomedical Informatics (Clifford), and Department of Emergency Medicine (Hudak), Emory University School of Medicine, Atlanta; Department of Psychiatry and Behavioral Neurosciences (Jovanovic) and Department of Emergency Medicine (Pearson, O'Neil), Wayne State University, Detroit; Department of Psychological Sciences, University of Missouri-St. Louis, St. Louis (Bruce); Department of Emergency Medicine, Washington University School of Medicine, St. Louis (House); Department of Psychology, Northern Illinois University, DeKalb (Hill); McLean Hospital, Belmont, Mass. (Phillips); Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore (Phillips); Department of Emergency Medicine and Department of Health Services, Policy, and Practice, Alpert Medical School of Brown University, Rhode Island Hospital, and Miriam Hospital, Providence, R.I. (Beaudoin); Institute for Trauma Recovery (An, Linnstaedt, McLean), Department of Anesthesiology (An, Linnstaedt), Department of Psychiatry (McLean), and Department of Emergency Medicine (McLean), University of North Carolina at Chapel Hill; Departments of Psychiatry and Neurology, University of California San Francisco, San Francisco (Neylan); Department of Biomedical Engineering, Georgia Institute of Technology, and Emory University, Atlanta (Clifford); Many Brains Project, Belmont, Mass. (Germine); Department of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester (Haran); Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tenn. (Storrow); Department of Emergency Medicine, Henry Ford Health System, Detroit (Lewandowski); Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis (Musey); Department of Emergency Medicine, University of Florida College of Medicine-Jacksonville (Hendry, Sheikh); Department of Emergency Medicine, Cooper Medical School of Rowan University, Camden, N.J. (Jones); Department of Emergency Medicine, University of Cincinnati College of Medicine, and College of Nursing, University of Cincinnati, Cincinnati (Punches); Department of Emergency Medicine, Oakland University William Beaumont School of Medicine, Rochester, Mich. (Swor); Department of Emergency Medicine, Boston Medical Center, Boston (McGrath); Department of Surgery and Department of Neurosurgery (Pascual), Department of Surgery, Division of Traumatology, Surgical Critical Care and Emergency Surgery (Seamon), and Perelman School of Medicine (Pascual, Seamon), University of Pennsylvania, Philadelphia; Department of Emergency Medicine, Einstein Healthcare Network, Philadelphia (Datner); Department of Emergency Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia (Datner); Department of Emergency Medicine, Jefferson University Hospitals, Philadelphia (Chang); Department of Emergency Medicine, Saint Joseph Mercy Hospital, Ypsilanti, Mich. (Domeier); Department of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield (Rathlev); Department of Emergency Medicine, McGovern Medical School, University of Texas Health, Houston (Sergot); Department of Emergency Medicine, Brigham and Women's Hospital, Boston (Sanchez); National Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston (Miller); Department of Psychiatry, Boston University School of Medicine, Boston (Miller); National Center for PTSD, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven (Pietrzak); Department of Psychiatry, Yale School of Medicine, New Haven, Conn. (Pietrzak); Department of Psychology, Yale University, New Haven, Conn. (Joormann); Department of Psychological and Brain Sciences, Washington University in St. Louis (Barch); Department of Biosciences and Institute for Behavioral Medicine Research, OSU Wexner Medical Center, Columbus, Ohio (Sheridan); Department of Psychiatry, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston (Smoller); Stanley Center for Psychiatric Research, Broad Institute, Cambridge, Mass. (Smoller); Department of Psychiatry, University of Pittsburgh, Pittsburgh (Luna); Department of Anesthesiology and Department of Internal Medicine-Rheumatology, University of Michigan Medical School, Ann Arbor (Harte); Kolling Institute of Medical Research, University of Sydney, St Leonards, New South Wales, Australia (Elliott); Faculty of Medicine and Health, University of Sydney, Northern Sydney Local Health District, New South Wales, Australia (Elliott); Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago (Elliott); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston (Koenen); Lurie Center for Autism, Lexington, Mass. (Ravichandran).

Objective: Dissociation, a disruption or discontinuity in psychological functioning, is often linked with worse psychiatric symptoms; however, the prognostic value of dissociation after trauma is inconsistent. Determining whether trauma-related dissociation is uniquely predictive of later outcomes would enable early identification of at-risk trauma populations. The authors conducted the largest prospective longitudinal biomarker study of persistent dissociation to date to determine its predictive capacity for adverse psychiatric outcomes following acute trauma. Read More

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Social support predicts sleep quality in people with multiple sclerosis during the COVID-19 pandemic.

Mult Scler Relat Disord 2022 Jun 14;64:103970. Epub 2022 Jun 14.

Department of Physical Therapy, Rehabilitation Science and Athletic Training, University of Kansas Medical Center, Kansas City, KS, USA.

Background: Poor sleep quality is one of the most prominent patient-reported problems in people with multiple sclerosis (PwMS). The COVID-19 pandemic resulted in PwMS having less contact with physicians, therapists, support groups, and family, which led to decreased access to typical supports. The purpose of this study was to assess how social support impacted sleep quality during the COVID-19 pandemic in PwMS within the United States. Read More

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Characterising the background incidence rates of adverse events of special interest for covid-19 vaccines in eight countries: multinational network cohort study.

BMJ 2021 06 14;373:n1435. Epub 2021 Jun 14.

Centre for Statistics in Medicine, NDORMS, University of Oxford, Oxford, UK

Objective: To quantify the background incidence rates of 15 prespecified adverse events of special interest (AESIs) associated with covid-19 vaccines.

Design: Multinational network cohort study.

Setting: Electronic health records and health claims data from eight countries: Australia, France, Germany, Japan, the Netherlands, Spain, the United Kingdom, and the United States, mapped to a common data model. Read More

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Distinct reproductive risk profiles for intrinsic-like breast cancer subtypes: pooled analysis of population-based studies.

J Natl Cancer Inst 2022 Jun 20. Epub 2022 Jun 20.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstr. 112, Stuttgart, 70376, Germany.

Background: Reproductive factors have been shown to be differentially associated with risk of estrogen receptor (ER) positive and ER-negative breast cancer. However, their associations with intrinsic-like subtypes are less clear.

Methods: Analyses included up to 23,353 cases, and 71,072 controls pooled from 31 population-based case-control or cohort studies in the Breast Cancer Association Consortium across 16 countries on 4 continents. Read More

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Emotional Word Processing in Patients With Juvenile Myoclonic Epilepsy.

Front Neurol 2022 1;13:875950. Epub 2022 Jun 1.

Department of Psychology, Naturwissenschaftliche Fakultaet, Centre for Cognitive Neuroscience, Paris-Lodron University, Salzburg, Austria.

Objective: According to Panksepp's hierarchical emotion model, emotion processing relies on three functionally and neuroanatomically distinct levels. These levels comprise subcortical networks (primary level), the limbic system (secondary level), and the neocortex (tertiary level) and are suggested to serve differential emotional processing. We aimed to validate and extend previous evidence of discrete and dimensional emotion processing in patient with juvenile myoclonic epilepsy (JME). Read More

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Serum anti-NMDA-receptor antibodies and cognitive function after ischemic stroke (PROSCIS-B).

J Neurol 2022 Jun 19. Epub 2022 Jun 19.

Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Center for Stroke Research Berlin (CSB), Charitéplatz 1, 10117, Berlin, Germany.

Objective: We aimed to investigate whether serum anti-N-methyl-D-aspartate-receptor GluN1 (previously NR1) antibody (NMDAR1-abs) seropositivity impacts cognitive function (CF) in the long term following ischemic stroke.

Methods: Data were used from the PROSpective Cohort with Incident Stroke-Berlin. NMDAR1-abs (IgM/IgA/IgG) were measured with cell-based assays from serum obtained within 7 days after the first-ever stroke. Read More

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DNA Methylation and Ischemic Stroke Risk: An Epigenome-Wide Association Study.

Thromb Haemost 2022 Jun 19. Epub 2022 Jun 19.

Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí, Barcelona, Spain.

Background: Ischemic stroke (IS) risk heritability is partly explained by genetics. Other heritable factors, such as epigenetics, could explain an unknown proportion of the IS risk. The objective of this study is to evaluate DNA methylation association with IS using epigenome-wide association studies (EWAS). Read More

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Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies.

Kidney Int 2022 Jun 15. Epub 2022 Jun 15.

The George Institute for Global Health, University of New South Wales, Sydney, Australia.

Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Read More

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Novel and modifiable factors associated with adherence to continuous positive airway pressure therapy initiated during stroke rehabilitation: An exploratory analysis of a prospective cohort study.

Sleep Med 2022 May 26;97:43-46. Epub 2022 May 26.

Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, 1959 NE Pacific St., Seattle, WA, 98195, USA; Department of Health Services, University of Washington School of Medicine, 1959 NE Pacific St., Seattle, WA, 98195, USA.

Objective/background: Continuous positive airway pressure (CPAP) for the treatment of sleep apnea may improve stroke recovery but is limited by poor adherence. We evaluated baseline features and psychosocial factors associated with CPAP adherence among stroke patients enrolled in a pilot study of an intensive CPAP adherence protocol initiated during inpatient rehabilitation.

Patients/methods: In a retrospective analysis of a prospective cohort study, we compared participants adherent to CPAP (≥4 h for ≥70% of nights over 3 months) to non-adherent participants. Read More

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Structural covariance changes in major cortico-basal ganglia and thalamic networks in amyloid-positive patients with white matter hyperintensities.

Neurobiol Aging 2022 May 27;117:117-127. Epub 2022 May 27.

Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Republic of Korea; Office of Biostatistics, Medical Research Collaborating Center, Ajou Research Institute for innovative Medicine, Ajou University Medical Center, Suwon, Republic of Korea. Electronic address:

Synergistic effects of amyloid deposition and cerebral small vessel disease (CSVD) on the systematic disruption of large-scale brain anatomical organization are not well known. We investigated the brain structural covariance network (SCN) in 245 cognitively impaired older adults with the information of amyloid deposition and CSVD represented by white matter hyperintensities (WMH). We stratified the participants into 4 groups based on amyloid burden (A+/A -) and WMH severity (W+/W-). Read More

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Precision medicine for genetic epilepsy on the horizon: recent advances, present challenges and suggestions for continued progress.

Epilepsia 2022 Jun 18. Epub 2022 Jun 18.

Department of Neurology, University of California, San Francisco, CA, USA.

The genetic basis of many epilepsies is increasingly understood, giving rise to the possibility of precision treatments tailored to specific genetic etiologies. Despite this, current medical therapy for most epilepsies remains imprecise, aimed primarily at empirical seizure reduction rather than targeting specific disease processes. Intellectual and technological leaps in diagnosis over the last ten years have not yet translated to routine changes in clinical practice. Read More

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Aerobic exercise training and neurocognitive function in cognitively normal older adults: A one-year randomized controlled trial.

J Intern Med 2022 Jun 17. Epub 2022 Jun 17.

Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA.

Background: Current evidence is inconsistent on the benefits of aerobic exercise training for preventing or attenuating age-related cognitive decline in older adults.

Objective: To investigate the effects of a one-year progressive, moderate-to-high intensity aerobic exercise intervention on cognitive function, brain volume, and cortical thickness in sedentary but otherwise healthy older adults.

Methods: We randomized 73 older adults to a one-year aerobic exercise or stretching-and-toning (active control) program. Read More

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Genome-wide polygenic score to predict chronic kidney disease across ancestries.

Nat Med 2022 Jun 16. Epub 2022 Jun 16.

Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.

Chronic kidney disease (CKD) is a common complex condition associated with high morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; however, this approach has not been optimized for ancestrally diverse populations. By combining APOL1 risk genotypes with genome-wide association studies (GWAS) of kidney function, we designed, optimized and validated a genome-wide polygenic score (GPS) for CKD. Read More

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