11,757 results match your criteria Medical Hypotheses[Journal]


The Perception Approach: Level of Observer Variability Rating and Fusion Diagnoses.

Med Hypotheses 2019 Feb 7;123:98-100. Epub 2019 Jan 7.

Institute of Pathology, Klinikum Augsburg, Augsburg, Germany.

Diagnostic uncertainty is a problem faced daily in clinical medicine. This uncertainty has many guises, such as vague wording in reports or pseudo-exact statements. High rates of intra- and interobserver variability and a corresponding low level of reproducibility are, unfortunately, issues that have to be taken into consideration in many medical fields. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2019.01.002DOI Listing
February 2019

Can immunization with Bacillus Calmette-Guérin (BCG) protect against Alzheimer's disease?

Med Hypotheses 2019 Feb 11;123:95-97. Epub 2019 Jan 11.

Department of Microbiology and Molecular Genetics, Hebrew University-Hadassah Faculty of Medicine, Jerusalem, Israel; Department of Neurology, Hadassah - Hebrew University Medical Center, Jerusalem, Israel.

Alzheimer's disease (AD) is a neurodegenerative disorder which is the most prevalent cause of dementia in the western world. Currently, it is the most expensive disease in America, costing more than heart diseases and cancer and as the world population is getting older it is expected to become the most expensive medical disorder in the world. AD is characterized by three core pathologies: accumulation of amyloid β (Aβ) plaques, neurofibrillary tangles (NFT) and sustained inflammation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2019.01.007DOI Listing
February 2019

Collagenous colitis development occurs after long standing mucosal healing in IBD with TNF-α inhibitors, and could be due to exaggerated healing response from excess TNF-α inhibition.

Med Hypotheses 2019 Feb 7;123:90-94. Epub 2019 Jan 7.

Section of Gastroenterology, Hepatology & Nutrition, Rush University Medical Center, Chicago, IL, United States. Electronic address:

Collagenous colitis is a relatively rare disorder affecting mainly middle-aged women where they present with chronic non-bloody diarrhea. Both with lymphocytic colitis they compose microscopic colitis. The exact cause of collagenous colitis is still unknown however; many potential pathophysiologic mechanisms have been proposed but no convincing mechanism has been identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2019.01.004DOI Listing
February 2019
1 Read

Adiponectin: A potential candidate for treating fibrosis in posterior segment of the eye.

Med Hypotheses 2019 Feb 7;123:9-12. Epub 2018 Dec 7.

R.S. Mehta Jain Department of Biochemistry and Cell Biology, KBIRVO, Vision Research Foundation, Chennai, India; Department of Biochemistry and Molecular Biology, Pondicherry University, Puducherry, India. Electronic address:

Fibrosis in ocular tissues causes severe visual deterioration and blindness in patients with glaucoma, cataract, age related macular degeneration (AMD) and diabetic retinopathy (DR). Currently available anti-fibrotic agents exhibit undesirous cytotoxic effects and thus prove ineffective to treat post-surgical fibrosis. Accordingly, there is a need to develop efficient and novel anti-fibrotic agents. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03069877183052
Publisher Site
http://dx.doi.org/10.1016/j.mehy.2018.12.005DOI Listing
February 2019
6 Reads

Neuromuscular taping reduces blood pressure in systemic arterial hypertension.

Med Hypotheses 2019 Feb 7;123:89. Epub 2019 Jan 7.

Physical Medicine and Rehabilitation, Umberto I Univeristy Hospital of Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2019.01.001DOI Listing
February 2019

Cerebral arteriovenous malformation venous stenosis is associated with hemodynamic changes at the draining vein-venous sinus junction.

Med Hypotheses 2019 Feb 7;123:86-88. Epub 2019 Jan 7.

Department of Neurosurgery, University of Illinois at Chicago, United States. Electronic address:

Cerebral arteriovenous malformations (AVMs) are an uncommon vascular anomaly that carry the risk of rupture and hemorrhage. Several factors have been implicated in the propensity of an AVM to bleed. One such factor is stenosis of AVM draining veins, as impairment of the AVM venous drainage system is associated with increased risk of intracranial hemorrhage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370035PMC
February 2019
1 Read

Physiology of aging.

Authors:
Jung Y Hahr

Med Hypotheses 2019 Feb 24;123:83-85. Epub 2018 Dec 24.

Children's Hospital of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, USA. Electronic address:

In a natural state, death of the neuronal cells of the central nervous system is a hallmark of the aging process and occurs very insidiously. As we age, a natural loss of the body water occurs simultaneously with a rise in plasma osmolality. When a progressive rise in plasma osmolality occurs with age, it increases the effective viscosity of the circulating blood, and the thickened blood fails to perfuse the body systems and organs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.12.016DOI Listing
February 2019

Association of silicone breast implants and acute renal allograft rejection.

Med Hypotheses 2019 Feb 21;123:81-82. Epub 2018 Dec 21.

School of Medicine, University of Zagreb, Zagreb, Croatia; Department of Urology, University Hospital Centre Zagreb, Zagreb, Croatia.

Silicone may, like any other adjuvant, induce an inflammatory reaction and diseases. There is no data about its use in renal transplant recipients. Increased immunogenicity of silicon may manifest by activation of both the innate and the adaptive immune system cells what promotes a chronic pro-inflammatory response. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.12.012DOI Listing
February 2019

Congenital simple hamartoma of the retinal pigment epithelium: What is the probable cause?

Med Hypotheses 2019 Feb 27;123:79-80. Epub 2018 Dec 27.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Room No 212, Second Floor, RPC-1, New Delhi 110029, India.

Congenital simple hamartoma of the retinal pigment epithelium is localized to the retinal tissue only with variable amount of surface extension. With consistent morphological and OCT features of the lesion around fovea, it appears that some of the embryologically undifferentiated ectopic progenitor cells destined for RPE within the retinal tissue may not undergo any further differentiation due to lack of necessary homeostatic factors leading to only hyperplasia and accumulation of the cells within the retina leading to simple hamartoma. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03069877183082
Publisher Site
http://dx.doi.org/10.1016/j.mehy.2018.12.019DOI Listing
February 2019
8 Reads
1.152 Impact Factor

EEG coherence as a diagnostic tool to measure the initial stages of Parkinson Disease.

Med Hypotheses 2019 Feb 24;123:74-78. Epub 2018 Dec 24.

Brain Mapping and Sensorimotor Integration Laboratory, Institute of Psychiatry of the Federal University of Rio de Janeiro (IPUB/UFRJ), Rio de Janeiro, RJ, Brazil.

Although Parkinson Disease was described a long time ago by James Parkinson and several biomarkers were used to predict the symptoms of PD, there is no accepted tool to distinguish the initial stages of this pathology. The present hypothesis discusses the Coherence Function, an Electroencephalography measure which could be used as a simple, and low-cost tool to describe the onset of cardinal signals of PD. Our hypothesis is based on three factors: beta frequency related to movement, motor action over particular cortical regions, and cortical coupling between cortical areas involved in the execution of voluntary movement. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03069877183110
Publisher Site
http://dx.doi.org/10.1016/j.mehy.2018.12.014DOI Listing
February 2019
3 Reads

The importance of ergothioneine synthesis in ancient time by organisms living in oxygen free atmosphere.

Med Hypotheses 2019 Feb 24;123:72-73. Epub 2018 Dec 24.

Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine of the Slovak Academy of Sciences, SK-84104 Bratislava, Slovakia.

The paper published by Ruczyszky and Liu (2017) reports on the biosynthesis of ergothioneine under both aerobic and anaerobic conditions. We would like to suggest a hypothesis as to what could be the reason that microorganisms on the Earth synthesized ergothioneine under anaerobic conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.12.015DOI Listing
February 2019

Is vitamin D deficiency behind the scenes for high incidence of Giant cell tumor amongst the Indian population? Unraveling the vitamin D - RANKL association.

Med Hypotheses 2019 Feb 21;123:67-71. Epub 2018 Dec 21.

Trauma and Orthopedics, Princess of Wales Hospital, Bridgend, United Kingdom.

Introduction: The major neoplastic and proliferative component of GCTB is the stromal tumor cells; that they have shown no evidence of bone destruction, instead the massive tissue destruction appears to be a result of tumor induced osteoclastogenesis. The discovery of receptor activator of nuclear factor kB (RANK) and RANK binding ligand (RANKL) uncovered the bone homeostasis and molecular mechanism by which multiple compounds (including vitamin D) regulated osteoclast differentiation; a function mediated by osteoblastic cells and osteoclast-precursor cells.

Hypothesis: In a country burdened by vitamin D deficiency, causal relation between hypovitaminosis D and GCTB was hypothesized based on the vitamin D mediated RANKL expression and osteoclastogenesis, as India is also a population with higher incidence of GCTB as compared to Western populations described in the literature. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03069877183112
Publisher Site
http://dx.doi.org/10.1016/j.mehy.2018.12.010DOI Listing
February 2019
1 Read

Is the "lactormone" a key-factor for exercise-related neuroplasticity? A hypothesis based on an alternative lactate neurobiological pathway.

Med Hypotheses 2019 Feb 24;123:63-66. Epub 2018 Dec 24.

Psychiatry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

For many years lactate was seen as a metabolite from glucose metabolism. However, since the last century researchers have shown that this molecule has an important role on liver, muscle, and brain metabolism. Lactate traffics along whole body mediating many biological processes depending on specific situations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.12.013DOI Listing
February 2019

Cancer related fatigue and cancer cachexia are the consequence of endocrine failure caused by persistent stress.

Authors:
Shaoqing Lai

Med Hypotheses 2019 Feb 24;123:60-62. Epub 2018 Dec 24.

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Electronic address:

This study researches the cause of tumor, cancer related fatigue (CRF) and cancer cachexia (CC), and the relationship among tumor and CRF and CC. Carcinogenesis is consequence of failure of tissue development. Tumor originates from tissue regeneration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.12.018DOI Listing
February 2019

Transient immunosuppression during short interruption of HAART: Another key to HIV cure in the "Berlin patient"?

Med Hypotheses 2019 Feb 7;123:6-8. Epub 2018 Dec 7.

Institute of Immunology, 24/2 Kashirskoe Sh., Moscow 115 478, Russia. Electronic address:

Transient immunosuppression in lentiviral infections leads to an auto-vaccination followed by the rise of serum neutralizing activity and a significant decrease in a set-point viral load, which becomes undetectable in some cases. Arguably, in the "Berlin patient" (Hütter G, et al., N Engl J Med, 2009) an induction chemotherapy-mediated transient immunosuppression episode during short interruption of HAART might have led to at least a "functional cure" before allogeneic stem cell transplantation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.12.002DOI Listing
February 2019
2 Reads

Density difference between perilymph and endolymph: A new hypothesis for light cupula phenomenon.

Med Hypotheses 2019 Feb 24;123:55-59. Epub 2018 Dec 24.

Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.

Light cupula is an emerging concept accounting for positional nystagmus. It can be diagnosed when persistent geotropic direction-changing positional nystagmus (PG DCPN) is observed in a head-roll test. Although hypotheses explaining light cupula phenomenon such as "light debris", "lighter cupula", and "heavier endolymph" have been proposed, the mechanism underlying light cupula has not been clearly elucidated yet. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.12.017DOI Listing
February 2019

Does aerobic exercise induced-analgesia occur through hormone and inflammatory cytokine-mediated mechanisms in primary dysmenorrhea?

Med Hypotheses 2019 Feb 21;123:50-54. Epub 2018 Dec 21.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong.

The popular accepted explanation for the pathogenesis of primary dysmenorrhea is elevated levels of uterine prostaglandins. Aetiological studies report that production of prostaglandins is controlled by the sex hormone progesterone, with prostaglandins and progesterone displaying an inverse relationship (i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.12.011DOI Listing
February 2019
1 Read

Subcortical visual pathway may be a new way for early diagnosis of glaucoma.

Med Hypotheses 2019 Feb 27;123:47-49. Epub 2018 Dec 27.

The Ophthalmology and Brain Cognition Collaboration Research Center of Zhongshan Ophthalmic Center and SIAT, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China. Electronic address:

Glaucoma is the leading cause of irreversible blindness worldwide, which is now viewed as a disease of brain with pathogenesis not fully understood. The main diagnostic methods are examining the retinal nerve fiber layer through optical coherence tomography and investigating visual field defect, but these methods present disadvantages in clinical practice. Studies have shown that patients with glaucoma often suffer negative emotion like anxiety and depression which is related to abnormal or reduced amygdala. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03069877183105
Publisher Site
http://dx.doi.org/10.1016/j.mehy.2018.12.020DOI Listing
February 2019
8 Reads

A theory of general intelligence.

Authors:
Hin Wai Lui

Med Hypotheses 2019 Feb 19;123:35-46. Epub 2018 Dec 19.

Interdisciplinary Programs Office, Hong Kong University of Science and Technology, Hong Kong. Electronic address:

This paper proposes a theoretical framework for the biological learning mechanism as a general learning system. The proposal is as follows. The bursting and tonic modes of firing patterns found in many neuron types in the brain correspond to two separate modes of information processing, with one mode resulting in awareness, and another mode being subliminal. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03069877183106
Publisher Site
http://dx.doi.org/10.1016/j.mehy.2018.12.001DOI Listing
February 2019
3 Reads

Hypothesis regarding the effects of gonadotropins on the level of free fatty acids and phospholipids in serum and follicular fluid during controlled ovarian stimulation.

Med Hypotheses 2019 Feb 18;123:30-34. Epub 2018 Dec 18.

Institute Vinca, University of Belgrade, Laboratory of Radiobiology and Molecular Genetics, Mike Petrovica Alasa 12-14, 11000 Belgrade, Serbia.

Controlled ovarian stimulation (COS) is used to augment the number of retrieved oocytes in in vitro fertilization (IVF). Follicular fluid (FF) contributes significantly to oocyte quality. Since the FF is composed of follicular secretions and plasma exudation, it reflects alterations in granulosa and thecal cells secretion as well as changes in the level of plasma constituents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.11.021DOI Listing
February 2019

A human mode of intestinal type gastric carcinoma.

Authors:
Shaoqing Lai

Med Hypotheses 2019 Feb 14;123:27-29. Epub 2018 Dec 14.

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Electronic address:

Gastric cancer is a malignant tumor originating from the gastric mucosa epithelium. Intestinal type gastric cancer is frequently taken on elderly men, and there are many high incidence areas around the world. Intestinal type gastric cancer often is accompanied by gastric mucosal atrophy, intestinal metaplasia. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03069877183121
Publisher Site
http://dx.doi.org/10.1016/j.mehy.2018.12.009DOI Listing
February 2019
6 Reads

Bioengineering application using co-cultured mesenchymal stem cells and preosteoclasts may effectively accelerate fracture healing.

Med Hypotheses 2019 Feb 11;123:24-26. Epub 2018 Dec 11.

Department of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, No. 88, Jiefang Road, Hangzhou 310009, China; Orthopedics Research Institute of Zhejiang University, No. 88, Jiefang Road, Hangzhou 310009, China. Electronic address:

Fracture non-union is the most challenging complication following fracture injuries. Despite ongoing improvements in the surgical technique and implant design, the treatment efficacy of fracture non-union is still far from satisfactory and currently there is no optimal solution. Of all of the methods used for the treatment of non-union, bone tissue bioengineering using scaffolds and mesenchymal stem cells (MSCs) is the most widely studied and has emerged as a promising approach to address these challenges. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.12.008DOI Listing
February 2019
1.152 Impact Factor

Aryl hydrocarbon receptor pathway participates in myocardial ischemia reperfusion injury by regulating mitochondrial apoptosis.

Med Hypotheses 2019 Feb 7;123:2-5. Epub 2018 Dec 7.

Department of Anesthesiology and Pain Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

Reducing ischemia reperfusion (I/R) injury has been a major challenge in the treatment of cardiovascular disease. It is widely accepted that mitochondrial apoptosis is an important link in myocardial infarction induced by I/R damage. Studies suggested that aryl hydrocarbon receptor (AhR) pathway plays an important role in the development and function of the cardiovascular system and regulating the mitochondrial homeostasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.12.004DOI Listing
February 2019

The reproductive life cycle of cancer: Hypotheses of cell of origin, TP53 drivers and stem cell conversions in the light of the atavistic cancer cell theory.

Med Hypotheses 2019 Feb 8;123:19-23. Epub 2018 Dec 8.

Kirschenweg 1, 86420 Diedorf, Germany. Electronic address:

Polyploid giant cancer cells (PGCCs) found in different solid cancers are reproductive cyst-like structures surrounded by an actin envelop. They give rise by hyper-polyploidisation to numerous progeny (microcells, neotic cells) that start a primitive multi-lined lineage and generate subsequent PGCCs by asymmetric cell division and cyclic differentiation. This cancer cell life cycle has multiple similarities with the life cycle of lower eukaryotes (protists) substantiating the atavistic theory of cancer. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03069877183045
Publisher Site
http://dx.doi.org/10.1016/j.mehy.2018.12.006DOI Listing
February 2019
3 Reads

Prisoner exposure to nature: Benefits for wellbeing and citizenship.

Med Hypotheses 2019 Feb 7;123:13-18. Epub 2018 Dec 7.

Department of Educational Psychology, University of Alberta, Edmonton, Alberta T6G 2G5, Canada; Forensic Psychiatry, Alberta Hospital Edmonton, 17480 Fort Road, Box 307, Edmonton, Alberta T5J 2J7, Canada.

The direct or indirect experience of crime can cause individuals to feel vengeful against the perpetrator(s). The prison system reflects this sentiment by creating austere environments that are dehumanizing, punitive, and hopeless. Prisons are, therefore, environments in which retribution and punishment take priority over rehabilitation. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03069877183035
Publisher Site
http://dx.doi.org/10.1016/j.mehy.2018.12.003DOI Listing
February 2019
2 Reads

Activated glycine receptors may decrease endosomal NADPH oxidase activity by opposing ClC-3-mediated efflux of chloride from endosomes.

Med Hypotheses 2019 Feb 16;123:125-129. Epub 2019 Jan 16.

Catalytic Longevity, United States; Departamento de Ciencias Quimico Biologicas, Universidad de Sonora, Mexico; Department of Preventive Cardiology, Saint Luke's Mid America Heart Institute, KS, United States.

Receptor-mediated activation of NADPH oxidase complexes commonly occurs in endosomes; the hydrogen peroxide produced by the dismutation of superoxide generated within the endosomes often functions to boost receptor function by reversibly inhibiting protein tyrosine phosphatases or by promoting formation of signaling complexes. NADPH oxidase-mediated formation of superoxide entails transfer of two electrons (provided by NADPH) from the cytosol to the endosomal lumen, where two molecules of superoxide are generated. This charge transfer must be balanced if NADPH oxidase activity is to be sustained. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2019.01.012DOI Listing
February 2019

Carbonic anhydrase enzymes: Likely targets for inhalational anesthetics.

Authors:
H Z Ozsoy

Med Hypotheses 2019 Feb 10;123:118-124. Epub 2019 Jan 10.

2515 Gramercy Street, Houston, TX 77030, United States. Electronic address:

Inhalational anesthetics such as isoflurane, desflurane and halothane are the mainstay medications for surgical procedures; upon inhalation, they produce anesthesia described as reversible unconsciousness with the features of amnesia, sleep, immobility and analgesia. To date, how they produce anesthesia is unknown. This study proposes that carbonic anhydrase enzymes are likely targets mediating the actions of inhalational anesthetics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2019.01.005DOI Listing
February 2019
1 Read

What decides the nature of extraocular muscle injury? The probable mechanism of flap tear and rupture.

Med Hypotheses 2019 Feb 16;123:115-117. Epub 2019 Jan 16.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, India.

The assessment of nature and the extent of extraocular muscle injuries during initial visit in ocular emergencies is of paramount importance to avoid/minimize the subsequent need for strabismus surgery. Based on our experience in managing acute globe and orbital injuries and cases of strabismus, we propose the probable mechanism involved in the occurrence of extraocular muscle flap tear and a complete rupture of the muscle. During high-velocity injuries when the forces are equally transmitted along the orbital bony framework and the globe, then due to differential shearing forces created between the global and the orbital fibres leads to a flap tear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2019.01.011DOI Listing
February 2019
1 Read

Obesity and inactivity, not hyperglycemia, cause exercise intolerance in individuals with type 2 diabetes: Solving the obesity and inactivity versus hyperglycemia causality dilemma.

Med Hypotheses 2019 Feb 16;123:110-114. Epub 2019 Jan 16.

Department of Physiology, Michigan State University, East Lansing, MI, United States. Electronic address:

Obesity, a sedentary lifestyle and type 2 diabetes are intricately linked conditions contributing to reduced exercise tolerance, significant morbidity, and premature deaths. It is unknown whether the reported exercise intolerance associated with type 2 diabetes is a direct result of the hyperglycemia, the impact of a relatively sedentary lifestyle, or increased adiposity. We hypothesize that obesity and inactivity, not hyperglycemia, cause exercise intolerance in individuals with type 2 diabetes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2019.01.013DOI Listing
February 2019
1 Read

Lateral epicondylalgia: A primary nervous system disorder.

Authors:
Diego Bordachar

Med Hypotheses 2019 Feb 11;123:101-109. Epub 2019 Jan 11.

Instituto Universitario del Gran Rosario (IUGR), Centro Universitario de Asistencia, Docencia e Investigación (CUADI), Unidad de Investigación Musculoesquelética (UIM), Argentina. Electronic address:

Lateral epicondylalgia (LE) is the most common chronic painful condition affecting the elbow in the general population. Although major advances have been accomplished in recent years in the understanding of LE, the underlying physiopathology is still a reason for debate. Differences in clinical presentation and evolution of the symptoms among patients, suggest the need for revisiting the current knowledge about subjacent mechanisms that attempt to explain pain and functional loss. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2019.01.009DOI Listing
February 2019

Expanding the spectrum of causative mutations of Marfan syndrome: Is there a role for the elastin gene?

Med Hypotheses 2019 Feb 7;123. Epub 2018 Dec 7.

Molecular Geneticist, Dipartimento di Medicina e di Scienze della Salute "Vincenzo Tiberio", Università degli Studi del Molise, Via Francesco De Sanctis, Campobasso, Italy; Fondazione Floresta Longo, Catania, Italy. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03069877183068
Publisher Site
http://dx.doi.org/10.1016/j.mehy.2018.12.007DOI Listing
February 2019
4 Reads

Captive uterus syndrome: An unrecognized complication of cesarean sections?

Authors:
I Hardy S Rousseau

Med Hypotheses 2019 Jan 24;122:98-102. Epub 2018 Oct 24.

Centre Hospitalier Universitaire de Montréal-Hôtel-Dieu, Former Chief of the Fertility Division, Canada.

Cesarean sections are a common surgical procedure at risk of complications including adhesions and chronic pelvic pain. This case series presents 10 cases of patients presenting with chronic pelvic pain following a cesarean section which were found upon surgical exploration to have developed adhesions between the abdominal wall and the uterus. When they first consulted, patients were evaluated clinically with a questionnaire and physical exam, and with ultrasonography to evaluate pelvic anatomy when necessary. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.10.010DOI Listing
January 2019
2 Reads

The cause-effect relationship between bone loss and Alzheimer's disease using statistical modeling.

Med Hypotheses 2019 Jan 29;122:92-97. Epub 2018 Oct 29.

University of Kansas School of Medicine, Kansas City, KS, USA.

Background: Animal studies provide strong evidence that the CNS directly regulates bone remodeling through the actions of the hypothalamus via two distinct pathways, the neural (mediated by leptin) arm and neurohumoral (mediated by neurohormones and growth factors) arm. The impact of AD on central regulatory mechanisms of bone mass is not known.

Objectives: To test a model that assesses the relationship between hypothalamic atrophy and bone loss in Alzheimer's disease (AD) and potential mediation through neural (leptin) and neurohumoral (insulin-like growth factor -1, IGF-1) mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318806PMC
January 2019
3 Reads

A hypothetical explanatory sensorimotor model of bilateral limb interference.

Med Hypotheses 2019 Jan 30;122:89-91. Epub 2018 Oct 30.

Graduate School of Health Science, Kio University, Nara, Japan; Neurorehabilitation Research Center, Kio University, Nara, Japan.

Goal-directed movements of a limb are optimized by sensorimotor integration, a process that merges both sensory and motor representations. In a previous study, we revealed that abnormal sensory representation can impair reach-to-grasp movements in patients with spinothalamocortical pathway lesions. This abnormal motor control was significantly recovered when referencing correct somatosensory information with the intact hand. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.10.025DOI Listing
January 2019

Transferred maternal fatty acids stimulate fetal adipogenesis and lead to neonatal and adult obesity.

Authors:
Andrew J Szabo

Med Hypotheses 2019 Jan 22;122:82-88. Epub 2018 Oct 22.

Lenox Hill Hospital, Division of Endocrinology and Metabolism, 100 East 77-th Street, New York, NY 10075, USA. Electronic address:

The prevalence of adult and childhood obesity are increasing. Most of the human newborn's body fat accumulates in the last half of intrauterine life. Fat in the fetus was thought to be mostly synthesized from glucose, but now it is commonly accepted that the bulk of it is the product of placental transfer of maternal fatty acids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.10.022DOI Listing
January 2019
2 Reads

On infusion of high-dose ascorbate in treating cancer: Is it time for N-acetylcysteine pretreatment to enhance susceptibility and to lower side effects?

Med Hypotheses 2019 Jan 11;122:8-9. Epub 2018 Oct 11.

Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, SK-84104 Bratislava, Slovakia.

Ascorbate administered intravenously gives a high plasma concentration of this drug. Clinical trials with pancreatic carcinoma patients revealed their prolonged survival if treated with intravenous ascorbate. On the other hand, high plasma ascorbate concentration leads to severe side effects, such as nephrotoxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.10.006DOI Listing
January 2019

Spatial gradient of bicoid is well explained by Birnbaum-Saunders distribution.

Med Hypotheses 2019 Jan 24;122:73-81. Epub 2018 Oct 24.

Department of Statistics, Payame Noor University, 19395-4697 Tehran, Iran.

bicoid is a maternally transcribed gene which plays a pivotal role during the early developmental stage of Drosophila melanogaster by acting as an essential input to the segmentation network. Therefore, fundamental insights into gene cross-regulations of segmentation network expect to be unveiled by presenting an accurate mathematical model for bicoid gene expression profile. In this paper, an extended version of Birnbaum-Saunders with four parameters is introduced and evaluated to describe the spatial gradient of this gene. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.10.023DOI Listing
January 2019
1.152 Impact Factor

Activation of the intracellular temperature and ROS sensor membrane protein STIM1 as a mechanism underpinning biological effects of low-level low frequency magnetic fields.

Med Hypotheses 2019 Jan 24;122:68-72. Epub 2018 Oct 24.

SciProof International AB, Östersund, Sweden.

The biological effects of low frequency magnetic fields (LF MF) at high flux densities are well known and the underlying mechanism is established. In contrast, health associated effects at lower flux densities, which can be found in the human environment, are controversial, and no accepted interaction mechanism has been presented. Here we present a hypothesis regarding the biological aspect of interaction between LF MF and cells. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03069877183099
Publisher Site
http://dx.doi.org/10.1016/j.mehy.2018.10.013DOI Listing
January 2019
6 Reads

Deciphering the metabolic secret of longevity through the analysis of metabolic response to stress on long-lived species.

Med Hypotheses 2019 Jan 22;122:62-67. Epub 2018 Oct 22.

Independent Researcher, Colomiers, France.

Despite intensive research, no satisfactory therapeutic options have been found for aging and age-related diseases. The British scientist Leslie Orgel stated that evolution is cleverer than we are. This assumption seems correct considering that some species are naturally able to resist the age-related diseases that remain unsolved by our modern medicine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.10.019DOI Listing
January 2019
1 Read

Role of sleep deprivation in the causation of postpartum obsessive-compulsive disorder.

Authors:
Verinder Sharma

Med Hypotheses 2019 Jan 22;122:58-61. Epub 2018 Oct 22.

Western University, London, Ontario, Canada; Parkwood Institute, London, Ontario, Canada. Electronic address:

First-onset or recurrence of obsessive-compulsive disorder (OCD) is common after childbirth. Postpartum OCD can occur alone or in combination with other psychiatric disorders such as mood and anxiety disorders. Putative etiological mechanisms involve consideration of genetic factors, alterations in the serotonin system secondary to changes in levels of gonadal hormones, rise in oxytocin, hypothalamic-pituitaryadrenal axis hyperactivity, and neuroinflammation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.10.016DOI Listing
January 2019
1 Read

Intrathecal cerebrospinal fluid infusion as a potential therapeutic strategy for Alzheimer's disease.

Med Hypotheses 2019 01 22;122:57. Epub 2018 Oct 22.

Department of Biomedical Sciences, Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands; Department of Neurology and Memory Clinic, Middelheim General Hospital (ZNA), Lindendreef 1, 2020 Antwerp, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.10.020DOI Listing
January 2019
1 Read

Rheumatoid arthritis revisited.

Med Hypotheses 2019 Jan 11;122:56. Epub 2018 Oct 11.

Lääkäriasema Joutsen, Finland. Electronic address:

The generally accepted theory of the etiopathology of rheumatoid arthritis has not led to a breakthrough so far, and the root cause of RA is still unknown. Surgical experience does not support the idea that the damage in the joint is caused by synovitis. Synovial tissue does not spread on the surface of the cartilage and thus destroy it, and neither is the erosion caused by the synovial tissue. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.10.007DOI Listing
January 2019
3 Reads

Differentiated thyroid cancer: Why does it affect predominantly women during the reproductive period and have higher incidence of mutual association with breast cancer?

Authors:
Atsushi Kurata

Med Hypotheses 2019 Jan 12;122:5-7. Epub 2018 Oct 12.

Department of Molecular Pathology, Tokyo Medical University, Tokyo, Japan. Electronic address:

Differentiated thyroid cancer (DTC) is markedly more common in women than men, and its occurrence and risk for poorer prognosis are associated with pregnancy. Further, it is known that there is a high frequency of co-occurrence of DTC and breast cancer. Although the underlying mechanisms that contribute to these phenomena are not entirely clear, 2 hypotheses are proposed here. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.10.008DOI Listing
January 2019
2 Reads

Nodular rheumatoid arthritis (RA): A distinct disease subtype, initiated by cadmium inhalation inducing pulmonary nodule formation and subsequent RA-associated autoantibody generation.

Med Hypotheses 2019 Jan 22;122:48-55. Epub 2018 Oct 22.

Department of Rheumatology, Royal Cornwall Hospital Trust, Truro, UK. Electronic address:

Nodular rheumatoid arthritis (RA) patients have raised rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) levels, and are more likely to smoke than RA patients without nodules. Subcutaneous and pulmonary rheumatoid nodules (granulomas) frequently co-exist. Pulmonary rheumatoid nodules develop prior to RA development and have the immunological machinery to generate RF and ACPAs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.10.021DOI Listing
January 2019
4 Reads

IGF - Autism prevention/amelioration.

Authors:
Gary Steinman

Med Hypotheses 2019 Jan 22;122:45-47. Epub 2018 Oct 22.

Department of Chemistry, Touro College in Israel, 11 Beit Hadfus Street, Jerusalem 95483, Israel. Electronic address:

Autism continues to be a significant cause of psychosocial pathology in affected children and adults. Until recently, the predominant research thrust to uncover the cause of this condition has been the search for a major nuclear mutation. Although a small percentage of cases do demonstrate such a DNA fault, recent effort has come to emphasize problems in the biochemistry of its sufferers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.10.015DOI Listing
January 2019

Reverse phenotype transfer via fecal microbial transplantation in inflammatory bowel disease.

Med Hypotheses 2019 Jan 22;122:41-44. Epub 2018 Oct 22.

Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08 Bratislava, Slovakia. Electronic address:

Inflammatory bowel disease (IBD) is characterized by a disbalance in the composition of intestinal microbiota. It is not clear whether such dysbiosis is a cause or a consequence of a disease state. Fecal microbiota transplantation (FMT) from a healthy donor to a patient or diseased animal is a valuable tool for targeted modification of microbiome leading to therapeutic response. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.10.017DOI Listing
January 2019

The Sudden Infant Death Syndrome mechanism of death may be a non-septic hyper-dynamic shock.

Med Hypotheses 2019 Jan 22;122:35-40. Epub 2018 Oct 22.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Pathology Department, Meir Medical Center, Kfar Saba, Israel.

Background: Sudden Infant Death Syndrome (SIDS) mechanisms of death remains obscured. SIDS' Triple Risk Model assumed coexistence of individual subtle vulnerability, critical developmental period and stressors. Prone sleeping is a major risk factor but provide no clues regarding the mechanism of death. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.10.018DOI Listing
January 2019
4 Reads

β-PVDF based electrospun nanofibers - A promising material for developing cardiac patches.

Med Hypotheses 2019 Jan 11;122:31-34. Epub 2018 Oct 11.

Department of Physics, Pondicherry University, India. Electronic address:

Necrosis in heart muscles can permanently hinder the natural healthy rhythm of heart pumping mechanism. The damaged muscular tissues are replaced by scar tissues and burdens the healthy muscles resulting in further attenuated functioning of heart. Since, human heart muscles cannot regenerate naturally or it has been thought so, pharmacological procedures such as using a heart assist device are followed to restore the lost function of heart. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03069877183072
Publisher Site
http://dx.doi.org/10.1016/j.mehy.2018.10.005DOI Listing
January 2019
11 Reads

Pleiotropic functions of plasmacytoid dendritic cells in the pathogenesis of the rheumatoid arthritis.

Med Hypotheses 2019 Jan 17;122:26-30. Epub 2018 Oct 17.

Department of Biochemistry, South-Ural State Medical University, Vorovskogo St., 64, Chelyabinsk 454092, Russia.

Rheumatoid arthritis is a chronic autoimmune inflammatory disease with an unclear etiology. The disease is characterized by infiltration of synovial tissue with immune cells, among which there are dendritic cells that play multifaceted roles in the pathogenesis of the disease. Here we shall assume that plasmacytoid dendritic cells are able to change their phenotype under the influence of various stimuli, thereby modulating the course of the disease, contributing to both the development of exacerbations and the induction of remissions depending on the phenotype they have acquired. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.10.009DOI Listing
January 2019
1 Read

Aerobic exercise promotes the expression of ERCC1 to prolong lifespan: A new possible mechanism.

Med Hypotheses 2019 Jan 17;122:22-25. Epub 2018 Oct 17.

Department of Physical Education & Shaanxi Key Laboratory of Brain Disorders & Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an 710021, China. Electronic address:

Aerobic exercise can delay aging and extend lifespan, but its specific mechanism still remains unclear. One popular theory is that with age and the cell division times increasing, DNA damage will inevitably accumulate, leading to dysfunction and failure of various tissues and organs, which will eventually lead to aging. Thus, repairing damaged DNA is a key strategy to extend lifespan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2018.10.012DOI Listing
January 2019