11,816 results match your criteria Medical Hypotheses[Journal]


Tea polyphenols as multi-target therapeutics for Alzheimer's disease: An in silico study.

Med Hypotheses 2019 Apr 14;125:94-99. Epub 2019 Feb 14.

Central Instrumentation Laboratory, Assam University, Silchar 788011, Assam, India.

Alzheimer's disease (AD) is the most common progressive neurodegenerative disease characterized by cognitive decline, dementia, and in later stages complete loss of feelings, sensation and death. The global prevalence of the disease is on the rise, and it affects 35-40% of the population above 80 years. The pathological hallmarks of the disease include extra-neuronal deposition of amyloid-β (Aβ) as plaques and intra-neuronal hyperphosphorylated tau protein as neurofibrillary tangles, which cause neurodegeneration and cerebral atrophy. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.035DOI Listing
April 2019
1.152 Impact Factor

Migraine associated with gastrointestinal disorders: A pathophysiological explanation.

Med Hypotheses 2019 Apr 19;125:90-93. Epub 2019 Feb 19.

Department of Iranian Traditional Medicine, Faculty of Medicine, Shahed University, Tehran, Iran.

Background: Migraine is a highly prevalent, disabling, and costly disorder worldwide. From a long time ago, headaches have been known to be associated with gastrointestinal (GI) disorders. Headaches originating from gastric complaints were appreciated by Persian Medicine (PM) scholars. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.041DOI Listing

Long term drug related remission may encourage drug withdrawal in patients with rheumatoid arthritis.

Med Hypotheses 2019 Apr 16;125:89. Epub 2019 Feb 16.

M.D., Kartal Dr. Lutfi Kirdar Training and Research Hospital, Department of Rheumatology, Kartal, 34680 Istanbul, Turkey. Electronic address:

Remission is the goal of therapy in patients with rheumatoid arthritis (RA). However, drug free remission has not been investigated adequately. Early and intensive treatment may increase the chances of successful drug free remission. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.038DOI Listing
April 2019
1 Read

The consumption of snacks and soft drinks between meals may contribute to the development and to persistence of gastro-esophageal reflux disease.

Authors:
E Fiorentino

Med Hypotheses 2019 Apr 11;125:84-88. Epub 2019 Feb 11.

University of Palermo, Department of Surgical, Oncological and Oral Sciences, Via Liborio Giuffrè 5, 90127 Palermo, Italy. Electronic address:

The Hypothesis: The habit of snacking and drinking soft beverages between breakfast, lunch and dinner, which is very widespread in the western world, could be a primum movens, thereby contributing to the development and subsequent persistence of gastroesophageal reflux disease (GERD). WHAT DOES THE PROPOSED HYPOTHESIS BASED ON?: The high prevalence of GERD suggests that it is very probably caused by factors, which are intrinsic and widespread in a western lifestyle. Ingesting snacks or imbibing soft drinks between breakfast, lunch and dinner causes additional gastric acid secretion, acid pocket formation, and additional transient lower esophageal sphincter relaxations (TLESRs) with acid reflux; the latter are proportional to the number of ingestions. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.034DOI Listing
April 2019
2 Reads

Memory in the hippocampus.

Authors:
Bompei Yasui

Med Hypotheses 2019 Apr 2;125:8-9. Epub 2019 Feb 2.

Nara-ken, Ikoma-shi, Tsuji-machi 882-16, 6300212, Japan. Electronic address:

To date, there is no clear evidence for memory formation. In this article, we provide a framework to understand how memory is formed. The information collected by sensory organs is converted to a digital current that enters the presynaptic neuron through axonal conductance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03069877183122
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http://dx.doi.org/10.1016/j.mehy.2019.02.008DOI Listing
April 2019
4 Reads

Low-intensity current (LIC) stimulation of subcutaneous adipose derived stem cells (ADSCs) - A missing link in the course of LIC based wound healing.

Med Hypotheses 2019 Apr 16;125:79-83. Epub 2019 Feb 16.

PE Society's Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India.

Millions of people die as a result of fatal injuries accounting for 9% of the total global annual deaths. Non fatal injuries generally result in variety of wounds. The normal wound healing process is slow and takes weeks to months, depending on the type of wound. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.039DOI Listing

Hypothesis: Can drug-loaded platelets be used as delivery vehicles for blood-brain barrier penetration?

Med Hypotheses 2019 Apr 16;125:75-78. Epub 2019 Feb 16.

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South Africa. Electronic address:

Neurovascular conditions are disorders associated with the blood vessels of the brain that are extremely difficult to treat successfully due to the selectivity and fastidious nature of the blood- brain barrier. Consequently, the efficacy of the pharmacological treatments for these conditions are greatly reduced thereby resulting in large amounts of neurovascular-related morbidity and mortality. Platelets are an important component of blood that actively respond to neurovascular distress in the body. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.037DOI Listing
April 2019
1 Read

Seeing the wood for the trees: A new way to view the human intestinal microbiome and its connection with non-communicable disease.

Med Hypotheses 2019 Apr 6;125:70-74. Epub 2019 Feb 6.

7 Blakelaw Road, Alnwick NE66 1AZ, UK.

Our paper briefly reviews the connection of the intestinal microbiome to the rise in non-communicable conditions related to atopic disease, obesity and mental health. We consider that the microbiome is best treated as if it were a single entity and have borrowed the terms semiochemical, allomone and kairomone (5) to describe interspecies relationship between the microbiome and ourselves (Fig. 1). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03069877183122
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http://dx.doi.org/10.1016/j.mehy.2019.02.016DOI Listing
April 2019
1 Read

The physical nature of subjective experience and its interaction with the brain.

Authors:
Fredric Schiffer

Med Hypotheses 2019 Apr 7;125:57-69. Epub 2019 Feb 7.

Developmental Biopsychiatry Research Program, McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, MA, USA. Electronic address:

Penrose and Hameroff assert that brain computations, including quantum computations, involving hydrophobic areas of microtubules whose electron clouds go into orchestrated superpositions and reductions that lead to proto-conscious elements, or "bings" that become orchestrated into conscious experiences. Their assertion, however, like the findings of the neural correlates of consciousness, does not explain subjectivity, but rather describes necessary conditions for it. Many scientists, including Panksepp, Demasio, and Tononi, have each made great contributions to the field, but none explains how material biological processes acquire subjectivity. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.011DOI Listing

Is muscle growth a mechanism for increasing strength?

Med Hypotheses 2019 Apr 13;125:51-56. Epub 2019 Feb 13.

Department of Health, Exercise Science, and Recreation Management, Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, University, MS, United States.

Skeletal muscle hypertrophy commonly occurs with repeated bouts of resistance exercise as well as following the administration of exogenous drugs. This increase in muscle size is thought to be mechanistically important for the increase in muscle function. However, at present, there is no experimental evidence that would support any paradigm in which muscle hypertrophy is a mechanism for increasing strength with exercise. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.030DOI Listing
April 2019
1 Read

Osteoporosis therapies might lead to intervertebral disc degeneration via affecting cartilage endplate.

Med Hypotheses 2019 Apr 2;125:5-7. Epub 2019 Feb 2.

Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, West Changle Road, Xi'an, 710032, China. Electronic address:

Osteoporosis and intervertebral disc degeneration (IDD) are both age-related diseases of the musculoskeletal system. With the average life expectancy longer than ever, the morbidity caused by these two diseases is increasing. Nowadays, treatment strategies for osteoporosis are mainly aimed at increasing the mineral density of the bone. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.003DOI Listing
April 2019
1 Read

Could the high consumption of high glycaemic index carbohydrates and sugars, associated with the nutritional transition to the Western type of diet, be the common cause of the obesity epidemic and the worldwide increasing incidences of Type 1 and Type 2 diabetes?

Authors:
Sture Sjöblad

Med Hypotheses 2019 Apr 10;125:41-50. Epub 2019 Feb 10.

Department of Paediatrics, University Hospital of Lund, Sweden.

The globally increasing incidences of Type 1 diabetes (T1DM) and Type 2 diabetes (T2DM) can have a common background. If challenged by the contemporary high level of nutritional glucose stimulation, the β-cells in genetically predisposed individuals are at risk for damage which can lead to the diseases. The fat to carbohydrate dietary shift can also contribute to the associated obesity epidemic. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03069877183099
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http://dx.doi.org/10.1016/j.mehy.2019.02.027DOI Listing
April 2019
8 Reads

Percolation theory for the recognition of patterns in topographic images of the cortical activity.

Med Hypotheses 2019 Apr 5;125:37-40. Epub 2019 Feb 5.

Neuroinnovation Technology & Brain Mapping Laboratory, Federal University of Piauí, Parnaíba, Brazil; Master Program in Biotechnology, Federal University of Piauí, Parnaíba, Brazil; The Northeast Biotechnology Network, Federal University of Piauí, Teresina, Brazil.

Electroencephalogram (EEG) is one of the mechanisms used to collect complex data. Its use includes evaluating neurological disorders, investigating brain function and correlations between EEG signals and real or imagined movements. The Topographic Image of Cortical Activity (TICA) records obtained by the EEG make it possible to observe, through color discrimination, the cortical areas that represent greater or lesser activity. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.021DOI Listing

Mysterious effects of olfactory pathway lesions on intestinal immunodeficiency targeting Peyer's patches: The first experimental study.

Med Hypotheses 2019 04 11;125:31-36. Epub 2019 Feb 11.

Ataturk University, Medical Faculty, Department of Neurosurgery, Erzurum, Turkey. Electronic address:

Background: Although olfaction has been considered as important neuroimmunomodulatory foundation, there is no satisfying analytical information between neurohistomorphological features olfactory networks and intestinal immune system hardwares. We studied if the olfactory bulb lesions (OBL) may rely on histopathological features of intestinal lymphatic Peyer's patches in an animal model.

Methods: Thirty-two rats were grouped as control (Group I, n = 8), SHAM (Group II, n = 7) and OBL (Group III, n = 17) respectively; and followed eight weeks and animals were decapitated. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.032DOI Listing
April 2019
5 Reads

Pathomechanism of optic nerve avulsion.

Med Hypotheses 2019 Apr 11;125:28-30. Epub 2019 Feb 11.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India.

Optic nerve avulsion following peri-orbital trauma is an enigmatic clinical entity. Several mechanisms and ideas have been put forward to derive a logical conclusion, however, each factor independently does not appear to explain the mechanism in a logical way, therefore, here we elaborate the probable chain of events responsible for this complication. During isolated blunt trauma to the orbital framework, the globe continues to move anteriorly without any active resistance, in contrast to the globe, the optic nerve with more delicate bony and soft tissue relations, likely to remain relatively static. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.031DOI Listing

Exaggerated arterial curves due to endovascular interventions: Novel concept that describes how curves in the arterial wall affect the formation of neointimal hyperplasia, and explains why the long-term results of endovascular interventions are inferior to the long-term results of open surgical procedures.

Authors:
Amr Salem

Med Hypotheses 2019 Apr 11;125:25-27. Epub 2019 Feb 11.

Department of Experimental and Clinical Surgery, Medical Research Institute, Alexandria University, Alexandria, Egypt. Electronic address:

Despite the vast advancement made in endovascular practice, it is still lacking the long-term success of open surgery in treating critical limb ischemia. In Bypass surgery excess length of the graft is cut to straighten it between the arterial anastomoses to avoid any excess length, in order to make sure that there will be no curves, but in endovascular approach this option is not available. In endovascular procedures, there are factors affecting negatively the long-term results. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.028DOI Listing

Psychedelic medicine: The biology underlying the persisting psychedelic effects.

Authors:
K P C Kuypers

Med Hypotheses 2019 Apr 11;125:21-24. Epub 2019 Feb 11.

Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, the Netherlands. Electronic address:

Psychedelic substances have regained interest as therapeutic agents in the treatment of stress-related disorders. The effects seem to be of persisting nature even after a single dose. Also in lower than 'regular' recreational doses, so-called micro-doses, without the typical effects on consciousness, users report beneficial effects on cognitive processes and well-being. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.029DOI Listing
April 2019
1 Read

A post-surgical adjunctive hypoxic therapy for myocardial infarction: Initiate endogenous cardiomyocyte proliferation in adults.

Med Hypotheses 2019 Apr 11;125:16-20. Epub 2019 Feb 11.

Department of Medical Technology, College of Medicine, Affiliated Hospital, Hebei University of Engineering, Handan 056002, PR China.

Myocardial infarction (MI) is a major threat to health worldwide, but today's methods for recovering heart function are limited, which is due largely to the deficient proliferative capacity of adult cardiomyocytes in the human body. To successfully overwhelm this deficiency, we propose a promising hypoxic therapy and highlight its unique role in directly eliciting endogenous myocardial regeneration in vivo. In the hypothesis, sufficient oxygen could be a restrictive factor of myocardial growth, whereas a moderate hypoxia might stimulate cardiomyocyte proliferation and enhance myocardial regeneration, heart weight and cardiac function recovery. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.033DOI Listing
April 2019
6 Reads

Is Interleukin-38 a key player cytokine in atherosclerosis immune gene therapy?

Med Hypotheses 2019 Apr 28;125:139-143. Epub 2019 Feb 28.

Young Researchers and Elite Club, Zanjan Branch, Islamic Azad University, Zanjan, Iran.

Atherosclerosis, a chronic inflammatory disease of the arteries associated with lipids and other metabolic alterations is a leading cause of death all around the world and its rate is raising as a result of unhealthy lifestyles. Reports by World Health Organization indicate that 31% of all death occurrences are due to heart attacks and strokes. Today, the most common medicines for treating atherosclerosis are statins which are HMG-coA reductase inhibitors. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.048DOI Listing
April 2019
1 Read

Prolactin and Prolactin-inducible protein (PIP) in the pathogenesis of primary acquired nasolacrimal duct obstruction (PANDO).

Med Hypotheses 2019 Apr 1;125:137-138. Epub 2019 Mar 1.

Institute of Functional and Clinical Anatomy, Friedrich-Alexander-University Erlangen-Núrnberg, Germany.

Primary acquired nasolacrimal duct obstruction (PANDO) is a syndrome of unknown etiology, predominantly affecting post-menopausal females, characterized by progressive inflammation, fibrosis and subsequent obstruction of the nasolacrimal duct. Numerous factors have been proposed as possible etiologic factors and include anatomical configuration, ocular and nasal infections, peri-lacrimal vascular disorders, hormonal influence, lacrimal drainage lymphoid tissue, gastroesophageal reflux disease, topical medications, swimming pool exposure, smoking, genetic factors, autonomic and lysosomal dysregulation. The authors hypothesize Prolactin (PRL) and Prolactin-inducible protein (PIP) play a role in the etiopathogenesis of primary acquired nasolacrimal duct obstruction. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.051DOI Listing
April 2019
1 Read

Alzheimer's disease might depend on enabling pathogens which do not necessarily cross the blood-brain barrier.

Authors:
Janice Block

Med Hypotheses 2019 Apr 21;125:129-136. Epub 2019 Feb 21.

Health Center, Center for Integrative Medicine, Nachal Achziv 8/2, Beit Shemesh, Israel; Kupat Cholim Leumit, Sfat Emet 4, Beit Shemesh, Israel. Electronic address:

The development of Alzheimer's Disease (AD) might reflect, in its acquired aspects, a cooperative pathogenesis whereby infectious enablers which do not necessarily cross the blood-brain barrier augment the invasive properties of a less virulent organism, thus enabling it to infect the brain. An example interaction is described which involves Chlamydia species, Human papillomavirus (HPV), microbiota, and yeast, where yeast is a pathogen of low virulence which crosses the blood-brain barrier. The cooperative pathogenesis begins at the mucosal epithelium. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.044DOI Listing
April 2019
2 Reads

The role of progesterone/estradiol ratio in exploring the mechanism of late follicular progesterone elevation in low ovarian reserve women.

Authors:
Johnny S Younis

Med Hypotheses 2019 Apr 28;125:126-128. Epub 2019 Feb 28.

Reproductive Medicine, Department of Obstetrics & Gynecology, Poriya Medical Center, Tiberias, Israel; Azrieili Faculty of Medicine, Galilee, Bar-Ilan University, Israel. Electronic address:

Late follicular progesterone (P) elevation continues to complicate a significant part of assisted reproductive technologies (ART) cycles, despite the ardent employment of gonadotropin releasing hormone (GnRH) analogues. In women with good ovarian reserve, late follicular P elevation is believed to be the result of the controlled ovarian stimulation (COS) itself, multiple follicular development and excessive ovarian steroidogenic activity. These mechanisms do not seem to be plausible in women with low ovarian reserve. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.047DOI Listing

Nonmelanoma skin cancer killed Mattia Preti (1613-1699), the "Calabrian Knight".

Med Hypotheses 2019 Apr 26;125:124-125. Epub 2019 Feb 26.

Legal Medicine Section, Department of Public Health and Paediatric Sciences, University of Turin, Italy; Warwick Medical School, Microbiology and Infection Division, University of Warwick, United Kingdom; UMR 7268, Laboratoire d'Anthropologie bio-culturelle, Droit, Etique & Santé (Adés), Faculté de Médecine de Marseille, France.

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http://dx.doi.org/10.1016/j.mehy.2019.02.045DOI Listing

PRE-binding protein of Plasmodium falciparum is a potential candidate for vaccine design and development: An in silico evaluation of the hypothesis.

Med Hypotheses 2019 Apr 11;125:119-123. Epub 2019 Jan 11.

Department of Life Science & Bioinformatics, Assam University, Silchar 788011, India. Electronic address:

Immunity to Plasmodium falciparum is contributed by many known and unknown factors. Lack of effective vaccine and rise in drug-resistant Plasmodium parasites leads to the major challenge in controlling the parasite. Determination of surface or secreted proteins which are essential for the survival of the pathogen is a very important step in finding potential vaccine candidates. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03069877183106
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http://dx.doi.org/10.1016/j.mehy.2019.01.006DOI Listing
April 2019
2 Reads

Helminth therapy for autism under gut-brain axis- hypothesis.

Med Hypotheses 2019 Apr 19;125:110-118. Epub 2019 Feb 19.

Department of Pathology and Laboratory Medicine, UC Davis School of Medicine; Institute for Pediatric Regenerative Medicine and Shriners Hospitals for Children of Northern California, United States. Electronic address:

Autism is a neurodevelopmental disease included within Autism Syndrome Disorder (ASD) spectrum. ASD has been linked to a series of genes that play a role in immune response function and patients with autism, commonly suffer from immune-related comorbidities. Despite the complex pathophysiology of autism, Gut-brain axis is gaining strength in the understanding of several neurological disorders. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.042DOI Listing
April 2019
1 Read

Could blood products obtained from patients with familial Mediterranean fever have beneficial or harmful effects?

Med Hypotheses 2019 Apr 18;125:109. Epub 2019 Feb 18.

Dokuz Eylul University School of Medicine, Department of Pediatrics, Divison of Rheumatology, Izmir, Turkey. Electronic address:

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http://dx.doi.org/10.1016/j.mehy.2019.02.040DOI Listing
April 2019
1 Read

Development of a semi-quantitative tear film based method for public screening of diabetes mellitus.

Med Hypotheses 2019 Apr 19;125:106-108. Epub 2019 Feb 19.

Dr RP Centre for Ophthalmic Sciences, AIIMS, New Delhi 110029, India.

Diabetes mellitus (DM) is a major health care burden associated with significant morbidity and serious impact on the quality of life. Estimating blood glucose levels is the currently employed method for screening for DM. Due to the invasive nature of access to blood glucose; new methods are being suggested that depend upon different targets than blood or another biochemical pathway altogether. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.043DOI Listing
April 2019
1 Read

Using extracellular calcium concentration and electric pulse conditions to tune platelet-rich plasma growth factor release and clotting.

Med Hypotheses 2019 Apr 16;125:100-105. Epub 2019 Feb 16.

GE Global Research Center, Niskayuna, NY, USA. Electronic address:

Platelet-rich plasma (PRP) is an emerging autologous biologic method for wound healing. Clinicians apply PRP either topically (where it is activated ex-vivo before treatment by adding an external agent to trigger clotting and the release of growth factors that facilitate wound healing) or through injection (where it is activated in vivo at the injury site with no prior activation before injection). Because topical PRP activation typically utilizes bovine thrombin, which has significant potential side effects and high costs, recent studies have assessed the efficacy of combining extracellular calcium (EC) and electric pulses (EPs) to activate PRP. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.036DOI Listing
April 2019
2 Reads

Computer simulation of transfusion with different blood product ratios in modern massive transfusion protocols.

Med Hypotheses 2019 Apr 2;125:10-15. Epub 2019 Feb 2.

Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston K7L 2V7, Ontario, Canada. Electronic address:

Modern massive transfusion protocols call for early plasma and platelets to patients presenting with hemorrhagic shock. The packed red blood cell (PRBC):plasma:platelet ratio generally ranges from 1:1:1 to 3:1:1, but the ideal ratio remains controversial. We aimed to determine the effects of different resuscitation strategies and blood product ratios on hematocrit, platelet and fibrinogen concentrations (FC) during resuscitation. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.004DOI Listing
April 2019
1 Read

Hypothesis of the optimal therapeutic effect of transcranial direct current stimulation (tDCS) for psychiatric disorders: Integration of positive cognitive tasks during the neuroplastic process.

Med Hypotheses 2019 Apr 2;125:1-4. Epub 2019 Feb 2.

Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan. Electronic address:

Transcranial direct current stimulation (tDCS) is a promising intervention for psychiatric disorders; however, little is known with regards to the optimal regime. As cognition, either spontaneously generated by patients or guided by treatment, is important in psychiatry, we have proposed a model that integrates cognition activity with the biological mechanisms of the therapeutic effect of tDCS in psychiatric disorders. We propose that the valence of the outcome of these mechanisms may be determined by the cognitive activity of the patient before or during tDCS treatment. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.013DOI Listing

Possible role of PPAR-γ and COX-2 receptor modulators in the treatment of Non-Small Cell lung carcinoma.

Med Hypotheses 2019 Mar 4;124:98-100. Epub 2019 Feb 4.

Department of Pharmacology, JSS College of Pharmacy (JSS Academy of Higher Education & Research), Rocklands, Udhagamandalam, Tamil Nadu 643 001, India.

Non-Small Cell lung cancer (NSCLC) accounts for 85% of total lung cancers worldwide, affecting more than 1.5 million people every year. Recent studies reported that lung adenocarcinoma express Peroxisome Proliferator Activated Receptor-γ (PPAR-γ) which is believed to be inactivated due to cytoplasmic accumulation or somatic 'loss of function' of the gene. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.024DOI Listing

Aging, metabolic acidosis and renal failure: Interactive accelerating processes.

Med Hypotheses 2019 Mar 4;124:95-97. Epub 2019 Feb 4.

University of California San Francisco, San Francisco CA, United States.

In this article, we hypothesize that eating a low acid (and particularly a low phosphate) diet and/or supplementing the diet with base precursors such as bicarbonate would have a number of helpful effects on aging, by:Although the present data is mainly from studies in invertebrate and small animal models, extrapolation of these results, as well as some associated results in human studies, suggests that low acid diets, or neutralization of the low grade metabolic acidosis seen in aging human subjects would possibly allow us to live longer and remain healthier. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.015DOI Listing

3D in vitro cancerous tumor models: Using 3D printers.

Med Hypotheses 2019 Mar 4;124:91-94. Epub 2019 Feb 4.

Cancer Biology Research Center, Tehran University of Medical Sciences, P.O. Box: 14197-33141, Iran. Electronic address:

Recently, magnetic Hyperthermia is one of the promising methods for cancer treatments. In this method by applying magnetic fields and generating heat, cancerous tissues are eliminated. The degree and pattern of generated heat in cancerous and adjacent non-cancerous tissues plays an important role on the outcome of the treatment. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.023DOI Listing

Notch signaling pathway mediates alveolar bone resorption in apical periodontitis.

Med Hypotheses 2019 Mar 4;124:87-90. Epub 2019 Feb 4.

Department of Human Genetics, School of Dental Medicine, University of Belgrade, dr. Subotica 1, 11 000 Belgrade, Serbia.

Apical periodontitis represents a chronic inflammatory process within periapical tissues, mostly caused by etiological agents of endodontic origin. Progressive bone resorption in the periapical region represents the hallmark of apical periodontitis and occurs as the consequence of interplay between polymicrobial infections and host response. The Notch signaling pathway is an evolutionary conserved cell-signaling system that plays an important role in a variety of cell functions including proliferation, differentiation and apoptosis. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.018DOI Listing
March 2019
1.152 Impact Factor

ATP in red blood cells as biomarker for sepsis in humans.

Med Hypotheses 2019 Mar 2;124:84-86. Epub 2019 Feb 2.

Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, Canada; Department of Pharmacology, Dalhousie University, Halifax, Canada; Department of Physiology and Biophysics, Dalhousie University, Halifax, Canada; Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada; Faculty of Computer Science, Dalhousie University, Halifax, Canada. Electronic address:

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to an infection. Due to the lack of causative immune treatment, mortality of sepsis remains at a high level and represents one of the main disease burdens globally. Adenosine 5' triphosphate (ATP) levels in red blood cells (RBC) are modulated by various factors during sepsis, including a decrease in ATP production, an increase in ATP catabolism and alterations in ATP release. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03069877183101
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http://dx.doi.org/10.1016/j.mehy.2019.02.014DOI Listing
March 2019
13 Reads

A minimally invasive robotic surgery approach to perform totally endoscopic coronary artery bypass on beating hearts.

Med Hypotheses 2019 Mar 2;124:76-83. Epub 2019 Feb 2.

Department of Medical Physics & Biomedical Engineering, School of Medicine, Iran; Research Center for Biomedical Technologies and Robotics (RCBTR), Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

The currently available robotic systems rely on rigid heart stabilizers to perform totally endoscopic coronary artery bypass (TECAB) surgery on beating hearts. Although such stabilizers facilitate the anastomosis procedure by immobilizing the heart and holding the surgery site steady, they can cause damage to the heart tissue and rupture of the capillary vessels, due to applying relatively large pressures on the epicardium. In this paper, we propose an advanced robotic approach to perform TECAB on a beating heart with minimal invasiveness. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.005DOI Listing
March 2019
1 Read

Impact of parenting on the development of chronic diseases in adulthood.

Med Hypotheses 2019 Mar 29;124:72-75. Epub 2019 Jan 29.

Norton Medical Group, Norton Healthcare, Louisville, KY 40241, USA. Electronic address:

The life course theory refers to a method developed in the 1960s that utilizes a multifaceted approach to evaluate people's lives, structural contexts, and social change. Adversities in childhood are associated with a heightened risk of chronic illnesses in adulthood. Parents play an important role in developing self-esteem, self-confidence, and effective coping mechanisms in their children. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.01.015DOI Listing

Myodesis or myoplasty in trans-femoral amputations. What is the best option? An explorative study.

Med Hypotheses 2019 Mar 16;124:7-12. Epub 2019 Jan 16.

University of Groningen, University Medical Centre Groningen, Department of Rehabilitation Medicine, Groningen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.mehy.2019.01.008DOI Listing
March 2019
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RISUG based improved intrauterine contraceptive device (IIUCD) could impart protective effects against development of endometrial cancer.

Med Hypotheses 2019 Mar 4;124:67-71. Epub 2019 Feb 4.

Indian Institute of Technology, School of Medical Science and Technology, Kharagpur 721302, India. Electronic address:

Intrauterine Contraceptive Devices with multifaceted application potential is a need of an hour. Although, copper-based IUDs exert an effective contraceptive as well as anticancer effects in a long-term basis, but also results in multiple complications. In this regard, RISUG a polymer based contraceptive device has been introduced as a suitable alternative. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.026DOI Listing
March 2019
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Pathomechanism of traumatic indirect choroidal rupture.

Med Hypotheses 2019 Mar 2;124:64-66. Epub 2019 Feb 2.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India.

The probable chain of events responsible for choroidal rupture is as follows. During high-speed orbital injuries, the protective ocular reflexes position the eye in an elevated, and abducted position. At this point in time, the anteroposterior compressive forces on to the globe create an eccentrically positioned circle of damaging currents along the posterior ocular coats against a relatively static optic nerve. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.010DOI Listing
March 2019
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1.152 Impact Factor

Laparoscopic promontofixation: Where to stop the anterior dissection?

Med Hypotheses 2019 Mar 2;124:60-63. Epub 2019 Feb 2.

Poissy University Hospital, Department of Obstetrics and Gynecology, 10 rue du Champ Gaillard, 78300 Poissy, France.

Background: Laparoscopic promontofixation is the gold standard to treat apical defects but the dissection of the anterior compartment is variable since based on surgical judgment only. We therefore evaluate the placement of the anterior mesh using an ultrasonographic measurement after promontofixation.

Design: A prospective cohort study (Canadian Task Force Classification II-1) was conducted between January 2015 and September 2015. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.006DOI Listing

Field dynamics in atrioventricular activation. Clinical evidence of a specific field-to-protein interaction.

Med Hypotheses 2019 Mar 2;124:56-59. Epub 2019 Feb 2.

Al Sabah Arrythmia Institute, Mount Sinai St. Luke's Hospital, New York, USA.

The atrioventricular node (AV) is considered the electrical connection between the atria and ventricles. There is an electrical pause between activation of the atria and the ventricles (PR segment), but to date the mechanism responsible for this interruption remains unclear. The present communication focuses on the hypothesis that magnetic field dynamics could provide the answer. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.012DOI Listing
March 2019
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Cannabis use during pregnancy: Are we at the verge of defining a "fetal cannabis spectrum disorder"?

Med Hypotheses 2019 Mar 4;124:53-55. Epub 2019 Feb 4.

Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel; Department of Anatomy, Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel; Dr. Miriam and Sheldon G. Adelson Center for the Biology of Addictive Diseases, Tel-Aviv University, Tel-Aviv, Israel.

Cannabis is probably the drug most commonly used globally since ancient times. Following the trend of legalization of access to cannabis in several Western countries, its use has increased in North America over the past few years. In spite of warnings of the potential hazards associated with in-utero exposure to cannabis, approximately 10% of pregnant women in an American study reported using cannabis in recent years, and most of them on a daily basis. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.017DOI Listing
March 2019
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Cellular stress and AMPK links metformin and diverse compounds with accelerated emergence from anesthesia and potential recovery from disorders of consciousness.

Authors:
Jahahreeh Finley

Med Hypotheses 2019 Mar 22;124:42-52. Epub 2019 Jan 22.

Finley BioSciences, Houston, TX 77042-4539, United States. Electronic address:

The neural correlates of consciousness and the mechanisms by which general anesthesia (GA) modulate such correlates to induce loss of consciousness (LOC) has been described as one of the biggest mysteries of modern medicine. Several cellular targets and neural circuits have been identified that play a critical role in LOC induced by GA, including the GABAA receptor and ascending arousal nuclei located in the basal forebrain, hypothalamus, and brain stem. General anesthetics (GAs) including propofol and inhalational agents induce LOC in part by potentiating chloride influx through the GABAA receptor, leading to neural inhibition and LOC. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.01.014DOI Listing
March 2019
6 Reads

Fructose-associated hepatotoxicity indexed by the lactate dehydrogenase isoenzyme LDH-5.

Med Hypotheses 2019 Mar 4;124:40-41. Epub 2019 Feb 4.

Breakspear Medical Group, Hemel Hempstead, Hertfordshire, UK.

Modern diets have become increasingly rich in fructose, for example through the addition of high-fructose corn syrup to many foods and drinks. It has been suggested that this might lead to hepatotoxicity, including the development of non-alcoholic fatty liver disease. After entering hepatocytes via insulin-independent glucose transporter 2 transmembrane carrier proteins, fructose is phosphorylated to fructose-1-phosphate in a reaction catalysed by fructokinase (ketohexokinase). Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.019DOI Listing

Psychosis is an extension of mood swings from the perspective of neuronal plasticity impairments.

Med Hypotheses 2019 Mar 2;124:37-39. Epub 2019 Feb 2.

Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan; Department of Nursing, Faculty of Health Science, Fukui Health Science University, 55 Egami-cho 13-1, Fukui-City, Fukui 910-3190, Japan. Electronic address:

We previously hypothesized that depressive and manic states may be consecutive presentations of the same underlying neuronal plasticity, and that moderate impairments in neuronal plasticity cause depressive states while further impairment to neuronal plasticity causes manic states. Psychopathological or biological relationships between bipolar disorder and schizophrenia have also been revealed. Therefore, in addition to depressive and manic states, psychosis may also be considered a manifestation resulting from additional impairments to neuronal plasticity. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.02.001DOI Listing
March 2019
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Surfactant proteins: Role in lacrimal drainage disorders.

Med Hypotheses 2019 Mar 24;124:35-36. Epub 2019 Jan 24.

Institute of Functional and Clinical Anatomy, Friedrich-Alexander-University Erlangen-Núrnberg, Germany.

Surfactants are complex mixtures of phospholipids and proteins produced by type II alveolar cells of the lungs and play a crucial role in pulmonary physiology. Six types of surfactant proteins (SP) are known; SP-A, SP-B, SP-C, SP-D, SP-G and SP-H. The major role of SP is in reducing surface tension and various immunological functions. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.01.020DOI Listing
March 2019
3 Reads

Is polycystic ovary syndrome a 20th Century phenomenon?

Med Hypotheses 2019 Mar 24;124:31-34. Epub 2019 Jan 24.

Discipline of Obstetrics and Gynaecology, School of Medicine, Robinson Research Institute, The University of Adelaide, Adelaide, SA 5005, Australia.

Polycystic ovary syndrome (PCOS) affects around 10% of women of reproductive age and is most common in developed countries. The aetiology of PCOS is not completely understood. Current evidence suggests that the syndrome results from a genetic predisposition interacting with developmental events during fetal or perinatal life that together increase susceptibility in some individuals. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.01.019DOI Listing
March 2019
2 Reads

Depleted uranium induces human carcinogenesis involving the immune and chaperoning systems: Realities and working hypotheses.

Med Hypotheses 2019 Mar 24;124:26-30. Epub 2019 Jan 24.

Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy; Department of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore - Institute of Marine and Environmental Technology (IMET), Baltimore, MD, USA.

Cancer is caused by a combination of factors, genetic, epigenetics and environmental. Among the latter, environmental pollutants absorbed by contact, inhalation, or ingestion are major proven or suspected culprits. Depleted uranium (DU) is one of them directly pertinent to the military and civilians working in militarized areas. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.01.018DOI Listing

Crocin may be useful to prevent or treatment of alcohol induced neurodegeneration and neurobehavioral sequels via modulation of CREB/BDNF and Akt/GSK signaling pathway.

Med Hypotheses 2019 Mar 24;124:21-25. Epub 2019 Jan 24.

Research and Development Department, Parsian-Exir-Aria pharmaceutical Company, Tehran, Iran.

The neurodegeneration and neurobehavioral consequences of alcohol are serious and offering therapeutic approaches for management of these types of neurodegeneration is one of the main concerns of researchers in this manner. Alcohol-stimulated oxidative stress, apoptosis and inflammation, with modulation of involved signaling pathway in neuroprotection, was reported previously. Neuroprotective strategy for management of alcohol induced neurodegeneration through a new generation neuroprotective agent and based on modulation of some neuroprotective signaling pathway such as CREB/BDNF and Akt/GSK has always been superior to any other therapeutic interventions. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.01.017DOI Listing
March 2019
1 Read