4,786,519 results match your criteria Medical Devices: Evidence and Research [Journal]


The Gynecologic Health Consequences of Chlamydia trachomatis Infection in Military Servicewomen.

Semin Reprod Med 2018 Nov 19;36(6):340-350. Epub 2019 Apr 19.

Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, Washington.

is the most common sexually transmitted bacterial infection in the United States. Within the U.S. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678752
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http://dx.doi.org/10.1055/s-0039-1678752DOI Listing
November 2018
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Preconception Care in the Veterans Health Administration.

Semin Reprod Med 2018 Nov 19;36(6):327-339. Epub 2019 Apr 19.

VA Central Office, Women's Health Services, Washington, District of Columbia.

Preconception care (PCC), defined as a set of interventions to help women optimize their health and well-being prior to pregnancy, can improve pregnancy outcomes and is recommended by national organizations including the Centers for Disease Control and Prevention and the American College of Obstetricians and Gynecologists. Women Veterans who use the Department of Veterans Affairs (VA) health care system may face elevated risks of adverse pregnancy and birth outcomes due to a high prevalence of chronic medical and mental health conditions as well as psychosocial stressors including sexual trauma history and intimate partner violence. Many women Veterans of childbearing age experience poverty and homelessness, which are key social determinants of poor reproductive health outcomes. Read More

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http://dx.doi.org/10.1055/s-0039-1678753DOI Listing
November 2018

Assisted Reproductive Technology and the Reproductive Endocrinology and Infertility Specialist in the U.S. Military.

Semin Reprod Med 2018 Nov 19;36(6):323-326. Epub 2019 Apr 19.

Walter Reed National Military Medical Center, Bethesda, Maryland.

The U.S. military mirrors the U. Read More

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http://dx.doi.org/10.1055/s-0039-1681084DOI Listing
November 2018

Reproductive Health of Women Veterans: A Systematic Review of the Literature from 2008 to 2017.

Semin Reprod Med 2018 Nov 19;36(6):315-322. Epub 2019 Apr 19.

Division of Gynecology, Department of Surgery, VA Boston Healthcare System, Boston, Massachusetts.

The literature on the reproductive health and healthcare of women Veterans has increased dramatically, though there are important gaps. This article aims to synthesize recent literature on reproductive health and healthcare of women Veterans. We updated a literature search to identify manuscripts published between 2008 and July 1, 2017. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678750
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November 2018
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Reproductive Health Needs of the Military and Veterans: Part 1.

Semin Reprod Med 2018 Nov 19;36(6):313-314. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

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http://dx.doi.org/10.1055/s-0039-1683423DOI Listing
November 2018

Reply to "Use of Serum Neuron-Specific Enolase Level to Predict Adverse Neurologic Outcomes after Aortic Surgery".

Authors:
Fumiaki Kimura

Thorac Cardiovasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiac Surgery, Asahikawa Medical University, Asahikawa, Japan.

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http://dx.doi.org/10.1055/s-0039-1685542DOI Listing

Outcome of a Modified Perceval Implantation Technique.

Thorac Cardiovasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiac Surgery, University Hospital Oldenburg, European Medical School Oldenburg-Groningen, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

Background:  In our institution, we developed a modification of the standard implantation technique of the Perceval sutureless aortic prosthesis (LivaNova, London, United Kingdom) that involves the usage of snuggers for the guiding sutures during valve deployment. The technique has been described elsewhere. In this article, we present the results of our initial case series comprising 128 consecutive patients. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685512
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http://dx.doi.org/10.1055/s-0039-1685512DOI Listing
April 2019
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Use of Serum Neuron-Specific Enolase Level to Predict Adverse Neurologic Outcomes after Aortic Surgery.

Thorac Cardiovasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Xi-Cheng District, Beijing, People's Republic of China.

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http://dx.doi.org/10.1055/s-0039-1685541DOI Listing

Placental programming of neuropsychiatric disease.

Pediatr Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatrics, Division of Neonatology, Children's Research Institute at Children's National Medical Center, Washington, DC, USA.

The placenta is vital for fetal growth, and compromised function is associated with abnormal development, especially of the brain. Linking placental function to brain development is a new field we have dubbed neuroplacentology. Approximately 380,000 infants in the United States each year abruptly lose placental support upon premature birth, and more than 10% of pregnancies are affected by more insidious placental dysfunction such as preeclampsia or infection. Read More

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http://dx.doi.org/10.1038/s41390-019-0405-9DOI Listing

Observed and calculated cerebral critical closing pressure are highly correlated in preterm infants.

Pediatr Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatrics, Neonatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.

Introduction: Cerebrovascular critical closing pressure (CrCP) is the arterial blood pressure (ABP) at which cerebral blood flow ceases. Preterm ABP is low and close to CrCP. The diastolic closing margin (diastolic ABP minus CrCP) has been associated with intraventricular hemorrhage in preterm infants. Read More

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http://dx.doi.org/10.1038/s41390-019-0403-yDOI Listing

Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats.

Neuropsychopharmacology 2019 Apr 19. Epub 2019 Apr 19.

Center for Addiction Research and Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.

Food intake is essential for survival, but maladaptive patterns of intake, possibly encoded by a preexisting vulnerability coupled with the influence of environmental variables, can modify the reward value of food. Impulsivity, a predisposition toward rapid unplanned reactions to stimuli, is one of the multifaceted determinants underlying the etiology of dysregulated eating and its evolving pathogenesis. The medial prefrontal cortex (mPFC) is a major neural director of reward-driven behavior and impulsivity. Read More

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http://dx.doi.org/10.1038/s41386-019-0394-8DOI Listing

Variation in hospital charges in patients with external ventricular drains: comparison between the intensive care and surgical floor settings.

J Neurosurg Pediatr 2019 Apr 19:1-6. Epub 2019 Apr 19.

3Department of Neurosurgery, University of Washington School of Medicine, Seattle, Washington.

OBJECTIVEPlacement of an external ventricular drain (EVD) is a common and potentially life-saving neurosurgical procedure, but the economic aspect of EVD management and the relationship to medical expenditure remain poorly studied. Similarly, interinstitutional practice patterns vary significantly. Whereas some institutions require that patients with EVDs be monitored strictly within the intensive care unit (ICU), other institutions opt primarily for management of EVDs on the surgical floor. Read More

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https://thejns.org/view/journals/j-neurosurg-pediatr/aop/art
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http://dx.doi.org/10.3171/2019.2.PEDS18545DOI Listing
April 2019
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Clinical outcome of V-Y flap with latissimus dorsi and gluteal advancement for treatment of large thoracolumbar myelomeningocele defects: a comparative study.

J Neurosurg Pediatr 2019 Apr 19:1-10. Epub 2019 Apr 19.

1Department of Neurosurgery.

OBJECTIVESurgical repair and closure of myelomeningocele (MMC) defects are important and vital, as the mortality rate is as high as 65%-70% in untreated patients. Closure of large MMC defects is challenging for pediatric neurosurgeons and plastic surgeons. The aim of the current study is to report the operative characteristics and outcome of a series of Iranian patients with large MMC defects utilizing the V-Y flap and with latissimus dorsi or gluteal muscle advancement. Read More

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http://dx.doi.org/10.3171/2019.1.PEDS18232DOI Listing

Predictors of endoscopic third ventriculostomy ostomy status in patients who experience failure of endoscopic third ventriculostomy with choroid plexus cauterization.

J Neurosurg Pediatr 2019 Apr 19:1-6. Epub 2019 Apr 19.

1Surgical Outcomes Center for Kids, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville.

OBJECTIVEAt failure of endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC), the ETV ostomy may be found to be closed or open. Failure with a closed ostomy may indicate a population that could benefit from evolving techniques to keep the ostomy open and may be candidates for repeat ETV, whereas failure with an open ostomy may be due to persistently abnormal CSF dynamics. This study seeks to identify clinical and radiographic predictors of ostomy status at the time of ETV/CPC failure. Read More

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https://thejns.org/view/journals/j-neurosurg-pediatr/aop/art
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http://dx.doi.org/10.3171/2019.2.PEDS18743DOI Listing
April 2019
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Adjacent-segment disease following two-level axial lumbar interbody fusion.

J Neurosurg Spine 2019 Apr 19:1-8. Epub 2019 Apr 19.

3Department of Orthopaedic Surgery, University of Tennessee College of Medicine, Chattanooga, Tennessee.

OBJECTIVEWhile long-term studies have evaluated adjacent-segment disease (ASD) following posterior lumbar spine arthrodesis, no such studies have assessed the incidence and prevalence of ASD following axial lumbar interbody fusion (AxiaLIF). The aim of this study was to estimate the incidence of ASD following AxiaLIF.METHODSThe authors retrospectively reviewed the medical records of 149 patients who underwent two-level index AxiaLIF and had at least 2 years of radiographic and clinical follow-up. Read More

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https://thejns.org/view/journals/j-neurosurg-spine/aop/artic
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http://dx.doi.org/10.3171/2019.2.SPINE18929DOI Listing
April 2019
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Validation of a freehand technique for cortical bone trajectory screws in the lumbar spine.

J Neurosurg Spine 2019 Apr 19:1-8. Epub 2019 Apr 19.

1Division of Orthopaedic Surgery, University of Toronto, Toronto.

OBJECTIVEThe cortical bone trajectory (CBT) technique for pedicle screw placement has gained popularity among spinal surgeons. It has been shown biomechanically to provide better fixation and improved pullout strength compared to a traditional pedicle screw trajectory. The CBT technique also allows for a less invasive approach for fusion and may have lower incidence of adjacent-level disease. Read More

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http://dx.doi.org/10.3171/2019.1.SPINE181402DOI Listing

Full tractography for detecting the position of cranial nerves in preoperative planning for skull base surgery: technical note.

J Neurosurg 2019 Apr 19:1-11. Epub 2019 Apr 19.

4Department of Neurosurgery, Stanford University Medical Center, Stanford, California.

OBJECTIVEDiffusion imaging tractography has allowed the in vivo description of brain white matter. One of its applications is preoperative planning for brain tumor resection. Due to a limited spatial and angular resolution, it is difficult for fiber tracking to delineate fiber crossing areas and small-scale structures, in particular brainstem tracts and cranial nerves. Read More

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http://dx.doi.org/10.3171/2019.1.JNS182638DOI Listing

The post-aSAH syndrome: a self-reported cluster of symptoms in patients with aneurysmal subarachnoid hemorrhage.

J Neurosurg 2019 Apr 19:1-10. Epub 2019 Apr 19.

2Neurosurgery, Oslo University Hospital; and.

OBJECTIVEAlthough many patients recover to a good functional outcome after aneurysmal subarachnoid hemorrhage (aSAH), residual symptoms are very common and may have a large impact on the patient's daily life. The particular cluster of residual symptoms after aSAH has not previously been described in detail and there is no validated questionnaire that covers the typical problems reported after aSAH. Many of the symptoms are similar to post-concussion syndrome, which often is evaluated with the Rivermead Post-Concussion Symptoms Questionnaire (RPQ). Read More

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http://dx.doi.org/10.3171/2019.1.JNS183168DOI Listing

Effect of glycolysis inhibition by miR-448 on glioma radiosensitivity.

J Neurosurg 2019 Apr 19:1-9. Epub 2019 Apr 19.

4Department of Neurosurgery, The Affiliated Hospital of Xiangnan University, Chenzhou, Hunan, People's Republic of China.

OBJECTIVEAlthough glucose metabolism reengineering is a typical feature of various tumors, including glioma, key regulators of glycolytic reprogramming are still poorly understood. The authors sought to investigate whether glycolysis inhibition by microRNA (miR)-448 increases radiosensitivity in glioma cells.METHODSThe authors used glioma tissue samples from glioma patients, cells from glioblastoma (GBM) cell lines and normal human astrocyte cells, and subcutaneous tumor-bearing U87 cells in mice to examine the effects of signaling regulation by miR-448 in the response of glioma tissues and cells to radiation treatment. Read More

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https://thejns.org/view/journals/j-neurosurg/aop/article-10.
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http://dx.doi.org/10.3171/2018.12.JNS181798DOI Listing
April 2019
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A narrative synthesis of possible causes and risk factors of hoarding behaviours.

Asian J Psychiatr 2019 Apr 8;42:104-114. Epub 2019 Apr 8.

Research Division, Institute of Mental Health, Buangkok Green Medical Park, 10 Buangkok View, 539747, Singapore. Electronic address:

Background: Hoarding is a disorder characterized by excessive acquisition and persistent difficulty in discarding possessions. The behaviour has adverse emotional, physical, social, financial, and legal outcomes for the person with the disorder and family members, and might pose a significant public health problem. Hoarding has been included as a distinct disorder in the Diagnostic and Statistical Manual of Mental Disorders Fifth edition (DSM-5). Read More

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http://dx.doi.org/10.1016/j.ajp.2019.04.001DOI Listing

Ultrasound images in hepatic alveolar echinococcosis and clinical stage of the disease.

Adv Med Sci 2019 Apr 16;64(2):324-330. Epub 2019 Apr 16.

Department of Tropical and Parasitic Diseases, University Centre of Maritime and Tropical Medicine (UCMMiT), Medical University of Gdansk, Gdynia, Poland; Department of Tropical Medicine and Epidemiology, Institute of Maritime and Tropical Medicine, Faculty of Health Sciences, Medical University of Gdansk, Gdynia, Poland.

Purpose: Hepatic alveolar echinococcosis (AE) is a parasitic disease caused by the larval stage of the tapeworm Echinococcus multilocularis. Ultrasonography is the method of choice in the initial diagnosis of AE. The aim of the study is to present the most frequent sonomorphological patterns of lesions in hepatic AE based on the analysis of ultrasound findings in patients treated for AE at the University Centre of Maritime and Tropical Medicine (UCMMiT; Gdynia, Poland), and to establish whether there is a relationship between the clinical stage of AE and the occurrence of a specific sonomorphological pattern of hepatic lesions. Read More

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http://dx.doi.org/10.1016/j.advms.2019.04.002DOI Listing

Quality of life in adults enrolled in an open-label study of cannabidiol (CBD) for treatment-resistant epilepsy.

Epilepsy Behav 2019 Apr 15;95:10-17. Epub 2019 Apr 15.

Department of Neurology, Division of Epilepsy, University of Alabama at Birmingham, Birmingham, AL, USA; UAB Epilepsy Center, University of Alabama at Birmingham, Birmingham, AL, USA.

Treatment-resistant epilepsy (TRE) is associated with low quality of life (QOL). Cannabidiol (CBD) may improve QOL, but it is unclear if such improvements are independent of improvements in seizure control. Our aim was to compare QOL at baseline and after 1 year of treatment with CBD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050193011
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http://dx.doi.org/10.1016/j.yebeh.2019.03.035DOI Listing
April 2019
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Personalizing therapy for older adults with acute myeloid leukemia: Role of geriatric assessment and genetic profiling.

Authors:
Vijaya Raj Bhatt

Cancer Treat Rev 2019 Apr 11;75:52-61. Epub 2019 Apr 11.

Department of Internal Medicine, Division of Hematology-Oncology, University of Nebraska Medical Center, Omaha, NE, United States; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, United States. Electronic address:

Acute myeloid leukemia (AML) presents therapeutic challenges in older adults because of high-risk leukemia biology conferring chemoresistance, and poor functional status resulting in increased therapy-related toxicities. Recent FDA approval of 8 new drugs for AML has increased therapeutic armamentarium and also provides effective low-intensity treatment options. Rational therapy selection strategies that consider individual's risk of therapy-related toxicities and probability of disease control can maximize benefits of available treatments. Read More

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http://dx.doi.org/10.1016/j.ctrv.2019.04.001DOI Listing

Development of a C1q-immobilized (Cim) assay to measure total antibodies to infliximab and its clinical relevance in patients with inflammatory bowel disease.

Cytokine 2019 Apr 16;120:54-61. Epub 2019 Apr 16.

IBD Centre, Toho University Sakura Medical Centre, Chiba, Japan. Electronic address:

Objective: Determination of antibodies to infliximab (ATI) is desirable for the management of patients with inflammatory bowel disease (IBD) who receive infliximab. Conventional ligand-binding ATI-assays detect only free-form of ATI, potentially increasing the proportion of patients with undetectable ATI, but with adequate trough infliximab (TRI) level who experience loss of response (LOR) to infliximab. We investigated this assertion using a novel ATI-Cim assay. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.014DOI Listing

Interleukin-18 serum levels in sepsis: Correlation with disease severity and inflammatory markers.

Cytokine 2019 Apr 16;120:22-27. Epub 2019 Apr 16.

Department of Anesthesiology and Intensive TherapyCare, 4th Military Hospital of Wroclaw, Weigla 5, 50-981 Wroclaw, Poland; Faculty of Health Science, Wroclaw Medical University, Wroclaw, Poland. Electronic address:

Purpose: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection and a syndrome shaped by pathogen and host factors with characteristic that evolve over time. The study was conducted to evaluate the prognostic and discriminative value of IL-18 assessment in comparison to PCT, CRP, WBC in early stage of sepsis and septic shock.

Methods: An observational and prospective study was conducted in the group of 40 ICU patients with diagnosis of sepsis or septic shock, serum PCT, IL-18, CRP and WBC measurements were performed on admission, and on the 2nd, 3rd and 5th therapy day. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.04.003DOI Listing

Bone and soft tissue changes associated with a removable partial denture. A novel method with a fusion of CBCT and optical 3D images.

Comput Biol Med 2019 Mar 28;108:78-84. Epub 2019 Mar 28.

Department of Endodontics and Operative Dentistry, Faculty of Medicine, University of Ljubljana, Slovenia; Department of Restorative Dentistry and Endodontics, University Medical Centre Ljubljana, Slovenia. Electronic address:

Background: The purpose of this study was to propose a novel method for 3D evaluation of bone and mucosal changes in removable partial denture (RPD) foundation area using a fusion of cone beam computed tomography (CBCT) and optical 3D images.

Method: Two CBCT scans and three impressions, taken at insertion and after ten months of wearing the RPD, were acquired from five patients. 3D models of bone and surface were created from CBCT images and gypsum casts, respectively, spatially aligned and saved in Standard Tessellation Language file format. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.024DOI Listing

Design of porous titanium scaffold for complete mandibular reconstruction: The influence of pore architecture parameters.

Comput Biol Med 2019 Mar 12;108:31-41. Epub 2019 Mar 12.

Department of Mechanical Engineering, Indian Institute of Technology Kharagpur, Kharagpur, 721 302, West Bengal, India. Electronic address:

Patients having a medical history of oral cancer, infectious diseases or trauma are often advised surgical intervention with customized complete mandibular constructs (CMC) made of Titanium (Ti) scaffolds. A numerical framework based on a homogenization technique was developed to investigate the influence of pore architecture parameters on homogenized orthotropic material properties of the scaffolds. A comparative 3D Finite Element (FE) analysis of six CMC models, having homogenized orthotropic material properties, under a mastication cycle, was undertaken to pre-clinically determine the optimal CMC for a patient. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00104825193007
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http://dx.doi.org/10.1016/j.compbiomed.2019.03.004DOI Listing
March 2019
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Evaluation of contingency management as a strategy to improve HCV linkage to care and treatment in persons attending needle and syringe programs: A pilot study.

Int J Drug Policy 2019 Apr 16;69:1-7. Epub 2019 Apr 16.

Division of General Internal Medicine, Montefiore Medical Center, United States. Electronic address:

Background: A greater proportion of HCV-infected people who inject drugs (PWID) need to be linked to care for HCV antiviral treatment. This study sets out to evaluate the efficacy of contingency management (CM) for improving HCV linkage to care, treatment initiation, adherence, and cure for PWID recruited from a needle and syringe program.

Methods: Between March 2015 and April 2016, 20 participants were enrolled into the CM arm, and then subsequently enrolled 20 participants in the enhanced standard of care (eSOC) arm. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09553959193006
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http://dx.doi.org/10.1016/j.drugpo.2019.02.009DOI Listing
April 2019
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Calcaneal tuberosity fractures through prior Schantz pin sites in patients with diabetic neuropathy.

Foot (Edinb) 2019 Mar 2;39:96-99. Epub 2019 Mar 2.

Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, United States.

Schantz pin placement in the calcaneal tuberosity is a common procedure known to be complicated by pin site infections and nerve injuries. Fractures through Schantz pin sites has been reported mostly in diaphyseal bone. This case series highlights three patients with type 2 diabetes mellitus and diabetic neuropathy who were fixed in an external fixator frame with a pin through the calcaneal tuberosity. Read More

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http://dx.doi.org/10.1016/j.foot.2019.02.011DOI Listing

Verapamil prevents the effect of calcium-sensing receptor activation on the blood glucose and insulin levels in rats.

Pharmacol Rep 2019 Jan 25;71(3):478-484. Epub 2019 Jan 25.

Department of Pathophysiology, Faculty of Pharmacy, Medical University of Gdańsk, Gdańsk, Poland. Electronic address:

Background: The Ca triggered insulin exocytosis in β cells of the pancreatic islets may be the result of Ca influx through L-type voltage dependent calcium channels (VDCC) localized in the plasma membrane, as well as of liberation of Ca from intracellular storages, induced by activation of the calcium receptor (CaR) coupled with the PLC enzyme present in the pancreatic islets. The present study was designated to determine, in in vivo experiments, the effects of CaR activation by R-568 and inhibition of the receptor by NPS 2143 on the plasma glucose and insulin levels in the presence of verapamil, a calcium channel blocker.

Methods: Wistar rats, after fasting for 14 h before the experiment, were anesthetized with inactin and loaded ip with 1 g/kg glucose. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.004DOI Listing
January 2019

Pixantrone, etoposide, bendamustine, rituximab (P[R]EBEN) as an effective salvage regimen for relapsed/refractory aggressive non-Hodgkin lymphoma-Polish Lymphoma Research Group real-life analysis.

Pharmacol Rep 2019 Feb 6;71(3):473-477. Epub 2019 Feb 6.

Department of Hematology, Jagiellonian University, Kraków, Poland.

Background: Despite a significant improvement in treatment outcomes, 30-40% of aggressive non-Hodgkin lymphomas (NHL) patients are refractory or relapse after the first line therapy. Half of them are not eligible to autologous stem cell transplantation (ASCT) due to failure of platinum-based salvage regimens. Pixantrone is conditionally approved in Europe in patients with R/R aggressive NHL failing at least 2 previous lines of therapy. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.001DOI Listing
February 2019

Influence of salbutamol on the anticonvulsant potency of the antiepileptic drugs in the maximal electroshock-induced seizures in mice.

Pharmacol Rep 2019 Feb 8;71(3):466-472. Epub 2019 Feb 8.

Department of Experimental and Clinical Pharmacology, Medical University, Lublin, Poland.

Background: β-Adrenergic receptor agonists are widely used agents in the treatment of asthma or preterm labor. Since prevalence of asthma was shown to be higher in patients with epilepsy and modulation of noradrenergic system activity may modify epilepsy course, the aim of the present study was to examine the effect of salbutamol (SALB), one of the most commonly used β-adrenergic receptor agonist on the anticonvulsant potency of four classical antiepileptic drugs (AEDs): valproate (VPA), carbamazepine (CBZ), phenytoin (DPH) and phenobarbital (PB) in mice subjected to the maximal electroshock (MES)-induced seizures.

Methods: Seizures were caused by a current delivered through ear-clip electrodes. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.003DOI Listing
February 2019

Evidence for antinociceptive effects of combined administration of vitamin E and celecoxib in tail-flick and formalin test in male rats.

Pharmacol Rep 2019 Feb 12;71(3):457-464. Epub 2019 Feb 12.

Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.

Background: The aim of this study was to evaluate the effect of vitamin E co-administration with celecoxib in thermal and inflammatory pain in two model of pain assessment including thermal tail flick test of acute pain and formalin induced inflammatory model in adult male rats.

Methods: Seventy two male Wistar rats were divided into a vehicle received intraperitoneally olive oil, indomethacin (20 mg/kg), vitamin E (100, 200 and 400 mg/kg), celecoxib (3, 10, 30 and 60 mg/kg) groups, and combination groups received the combination of vitamin E (100 and 200 mg/kg) and celecoxib (3, 10 and 30 mg/kg). All drugs were dissolved in olive oil. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.005DOI Listing
February 2019

The role of rapid onset fentanyl products in the management of breakthrough pain in cancer patients.

Pharmacol Rep 2019 Jan 31;71(3):438-442. Epub 2019 Jan 31.

Chair and Department of Palliative Medicine, Poznan University of Medical Sciences, Poznań, Poland. Electronic address:

Breakthrough pain is defined as transient aggravation of pain that arises, despite well controlled or stable baseline pain. It may be preceded by known factors or occur spontaneously. Its prevalence is high and it considerably affects patients' quality of life. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.010DOI Listing
January 2019

The effect of atorvastatin on cardiometabolic risk factors in women with non-classic congenital adrenal hyperplasia: A pilot study.

Pharmacol Rep 2019 Jan 31;71(3):417-421. Epub 2019 Jan 31.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Background: Individuals with non-classic congenital adrenal hyperplasia (NC-CAH) often show evidence of hyperandrogenism, including premature pubarche, accelerated linear growth velocity, short final height, hirsutism, acne, alopecia, impaired ovulation, menstrual dysfunction and subfertility. Although statins were found to reduce elevated levels of androgens in subjects with this disorder, no previous study has investigated whether 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors affect cardiometabolic risk factors in patients with NC-CAH.

Methods: We studied 12 women with NC-CAH, 6 of whom because of coexisting hypercholesterolemia received atorvastatin (20-40 mg daily). Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.014DOI Listing
January 2019

Discoidin domain receptor 2: An emerging pharmacological drug target for prospective therapy against osteoarthritis.

Pharmacol Rep 2019 Jan 15;71(3):399-408. Epub 2019 Jan 15.

Department of Pharmaceutical Sciences, Drug Discovery Research Laboratorty, Assam University, Silchar, Assam, India. Electronic address:

Discoidin domain receptor2 (DDR2), a cell membrane tyrosine kinase on chondrocytes surface plays main role in cell-ECM interaction during the progressive degeneration of articular cartilage in osteoarthritis. The degraded component of ECM, type II collagen upon DDR2 binding provokes synthesis of matrix metalloproteinases (MMPs), responsible for severe destruction of joint tissues. DDR2 knockout has been investigated to decline the expression of MMP-1 and 13. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.007DOI Listing
January 2019
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The safety and efficacy of Guluronic acid (G2013) in ankylosing spondylitis: A randomized controlled parallel clinical trial.

Pharmacol Rep 2019 Feb 10;71(3):393-398. Epub 2019 Feb 10.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: To assess the therapeutic efficacy, safety and tolerability of Guluronic acid (G2013) in patients with ankylosing spondylitis (AS) patients.

Methods: This investigation was a 12-week randomized, placebo-controlled, phase I/II clinical trial involving 75 AS patients that were randomly divided into 3 groups: 25 as placebo, 25 Guluronic acid and 25 naproxen groups. Patients who had AS with active disease at baseline according to the modified New York criteria were considered for this trial. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.002DOI Listing
February 2019

Recipient ABCB1, donor and recipient CYP3A5 genotypes influence tacrolimus pharmacokinetics in liver transplant cases.

Pharmacol Rep 2019 Jan 11;71(3):385-392. Epub 2019 Jan 11.

Dept of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India.

Background: Effective immunosuppression through optimization of trough levels tacrolimus reduces post-transplant mortality rate in liver transplant cases.

Methods: Meta-analysis was carried out to evaluate how donor/recipient CYP3A5 (n = 678) and recipient ABCB1 (n = 318) genotypes influence tacrolimus pharmacokinetics till one-month of transplantation.

Results: The donor CYP3A5*3/*3 genotype exhibited higher concentration/dose (C/D) ratio of tacrolimus in week 1 (mean difference: 65. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.006DOI Listing
January 2019

Examining reactivity patterns in burnout and other indicators of chronic stress.

Psychoneuroendocrinology 2019 Apr 4;106:195-205. Epub 2019 Apr 4.

Department of Psychology, TU Dresden, Germany.

Introduction: Burnout symptomatology is associated with various negative health consequences; however, the mechanisms underlying these associations remain unclear. One potential pathway involves alterations in the acute stress response. The aims of the present study were to examine burnout-associated alterations in stress-reactivity patterns, during a standardized social stressor compared to a control condition, as well as to examine whether effects associated with greater burnout symptomatology were distinct from other, conceptually overlapping indicators of chronic stress (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064530183115
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http://dx.doi.org/10.1016/j.psyneuen.2019.04.002DOI Listing
April 2019
1 Read

Moderate hearing loss is related with social frailty in a community-dwelling older adults: The Korean Frailty and Aging Cohort Study (KFACS).

Arch Gerontol Geriatr 2019 Apr 12;83:126-130. Epub 2019 Apr 12.

Department of Family Medicine, Kyung Hee University Medical Center, kyungheedaero 23, dongdaemun-gu, 02447, Seoul, Republic of Korea; Elderly Frailty Research Center, Department of Family Medicine, Kyung Hee University College of Medicine, kyungheedaero 23, dongdaemun-gu, 02447, Seoul, Republic of Korea. Electronic address:

Objectives: To determine whether hearing loss is associated with social frailty in older adults.

Methods: Cross-sectional analysis of cohort study data. Hearing was measured using of Pure-tone audiometry. Read More

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http://dx.doi.org/10.1016/j.archger.2019.04.004DOI Listing

Association between sarcopenia and diabetes in community dwelling elderly in the Amazon region - Viver Mais Project.

Arch Gerontol Geriatr 2019 Mar 27;83:121-125. Epub 2019 Mar 27.

State University Of Pará, Brazil; Hospital Cynthia Charone, Brazil.

Background: Studies indicate the intrinsic relationship between sarcopenia and diabetes mellitus (DM) pathophysiological mechanisms. Changes in insulin and muscular metabolism are features of diabetic patients and can interact as sarcopenic accelerators. Conversely, sarcopenic patients feature lower glucose tolerance and higher serum insulin levels, predisposing them to DM. Read More

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http://dx.doi.org/10.1016/j.archger.2019.03.020DOI Listing

Calibration of polydimethylsiloxane and polyurethane foam passive air samplers for measuring semi volatile organic compounds using a novel exposure chamber design.

Chemosphere 2019 Apr 8;227:435-443. Epub 2019 Apr 8.

Department of Physical and Environmental Science, University of Toronto Scarborough, 1265 Military Trail Toronto, Ontario, M1C 1A4, Canada; Department of Earth Sciences, 22 Russell Street, University of Toronto, Toronto, Ontario, M5S 3B1, Canada.

Passive air sampling is increasingly used for air quality monitoring and for personal sampling. In a novel experimental exposure chamber study, 3 types of polydimethylsiloxane (PDMS, including sheet and wristband) and 1 type of polyurethane foam (PUF) passive air samplers were tested for gas-phase uptake of 200 semi volatile organic compounds (SVOCs) during six months. For 155 SVOCs including PAH, PCB, phthalates, organophosphate esters, musk compounds, organochlorine- and other pesticides, a normalized generic uptake rate (Rs) of 7. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535193069
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http://dx.doi.org/10.1016/j.chemosphere.2019.04.043DOI Listing
April 2019
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PCB52 induces hepatotoxicity in male offspring through aggravating loss of clearance capacity and activating the apoptosis: Sex-biased effects on rats.

Chemosphere 2019 Apr 12;227:389-400. Epub 2019 Apr 12.

Department of Forensic Pathology, School of Forensic Medicine, Southern Medical University, No. 1838 North Guangzhou Road, 510515, Guangzhou, China. Electronic address:

Polychlorinated biphenyls (PCBs), a kind of persistent organic pollutant, can induce hepatotoxicity in mammals. However, PCB-induced hepatotoxicity in offspring and the underlying mechanisms have been rarely studied. In the present study, Wistar rats were administered with corn oil or PCB52 (1 mg/kg body weight/day, by gavage) from gestational day 7 to postnatal day 21. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535193072
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http://dx.doi.org/10.1016/j.chemosphere.2019.04.077DOI Listing
April 2019
2 Reads

EEG correlates of face recognition in patients with schizophrenia spectrum disorders: A systematic review.

Clin Neurophysiol 2019 Apr 10;130(6):986-996. Epub 2019 Apr 10.

Moscow Research Institute of Psychiatry - the Branch of V. Serbsky National Medical Research Centre for Psychiatry and Narcology, Moscow, Russian Federation.

Objective: To systematically assess EEG studies and evaluate neuropsychological changes of face recognition in the context of neutral face stimuli in individuals with schizophrenia spectrum disorders.

Methods: A literature search was conducted using the PubMed database from inception to March 2018. Studies included in the review measured any event-related potentials, neural oscillations, or phase synchrony. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.03.027DOI Listing

Heritability estimates of individual psychological distress symptoms from genetic variation.

J Affect Disord 2019 Apr 8;252:413-420. Epub 2019 Apr 8.

Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea. Electronic address:

Background: Psychological distress symptoms are associated with an increased risk of psychiatric disorders and medical illness. Although psychological distress is influenced by environmental factors, such as socioeconomic status, lifetime events, or interpersonal relationships, substantial interindividual variation also exists. However, heritability and genetic determinants of distress are poorly understood. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.011DOI Listing

Connecting experts in the agricultural and meteorological sciences to advance knowledge of pest management in a changing climate.

Sci Total Environ 2019 Apr 10;673:694-698. Epub 2019 Apr 10.

Experimental Allergy Laboratory, Department of Dermatology, Medical University of Vienna, Vienna, Austria.

There has been considerable progress in elucidating the physical aspects of climate change that directly impact food, feed, and fiber production. However, these impact assessments rarely account for climate induced changes associated with biological pests. The lack of collaboration between the pest management and climate science disciplines could be contributing to the problem. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193165
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http://dx.doi.org/10.1016/j.scitotenv.2019.04.126DOI Listing
April 2019
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Midgut volvulus is a rare cause of intestinal obstruction in adults: A case report.

Int J Surg Case Rep 2019 Apr 4;58:41-44. Epub 2019 Apr 4.

Sina Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Introduction: The incidence of midgut vovulus is rare in adults. However, a significant number of cases were seen in infant and children.

Presentation Of Case: We report a case of a 34-year-old male who presented to the emergency room with persistent periumbilical abdominal pain without any other symptoms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193014
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http://dx.doi.org/10.1016/j.ijscr.2019.03.029DOI Listing
April 2019
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Submucosal mucoid as a late complication after appendectomy-A case report.

Int J Surg Case Rep 2019 Apr 5;58:37-40. Epub 2019 Apr 5.

Radiological Department, Klatovy Hospital, Plzeňská 929, 339 01, Klatovy II, Czech Republic.

Introduction: Shortly after an operation infection, intraabdominal abscess, seroma, haemorrhage or development of paralytic ileus may occur. Postoperative adhesions, nonspecific abdominal pain without signs of obstruction, incisional hernia and appendicitis or mucocele in appendiceal stump present common late complications. We present a unique case of a late complication after appendectomy. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.051DOI Listing

Achievement of low density lipoprotein (LDL) cholesterol targets in primary and secondary prevention: Analysis of a large real practice database in Italy.

Atherosclerosis 2019 Apr 8;285:40-48. Epub 2019 Apr 8.

Hypertension Unit, Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University of Rome Sapienza, Sant'Andrea Hospital, Rome, Italy; IRCCS Neuromed, Pozzilli, IS, Italy. Electronic address:

Background And Aims: Target and intensity of low-density lipoprotein cholesterol (LDL-C) lowering therapy should be tailored according to the individual global cardiovascular (CV) risk. We aimed at retrospectively evaluating real-life LDL-C goal attainment and predictive factors for predefined LDL-C therapeutic goals both in primary and secondary prevention.

Methods: We collected data from a large cohort of outpatients aged 40-65 years, followed by general practitioners, cardiologists and diabetologists in Italy. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.03.017DOI Listing

LncRNA ENST00000602558.1 regulates ABCG1 expression and cholesterol efflux from vascular smooth muscle cells through a p65-dependent pathway.

Atherosclerosis 2019 Apr 8;285:31-39. Epub 2019 Apr 8.

Key Laboratory of Cardiovascular Epidemiology & Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China.

Background And Aims: Long non-coding RNAs (lncRNAs) have proven to be involved in the progression of atherosclerosis and dyslipidemia. In addition, vascular smooth muscle cells (VSMCs) phenotype switching, including VSMCs-derived foam cells formation, plays a key role in the pathogenesis of atherosclerosis. LncRNA ENST00000602558. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.04.204DOI Listing
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