4,715,996 results match your criteria Medical Devices: Evidence and Research [Journal]


Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder.

Neuropsychopharmacology 2019 Feb 16. Epub 2019 Feb 16.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.

Recent European genome-wide association studies (GWAS) have revealed strong statistical correlations between MDD and numerous zero-to-high linked variants in the genomic region containing major histocompatibility complex (MHC) genes (MHC region), but the underlying molecular mechanisms are still unclear. To better understand the roles of this genomic region in the neurobiology of MDD, we applied a convergent functional genomics approach to integrate GWAS data of MDD relevant biological phenotypes, gene-expression analyses results obtained from brain samples, and genetic analyses of independent Chinese MDD samples. We observed that independent MDD risk variants in the MHC region were also significantly associated with the relevant biological phenotypes in the predicted directions, including the emotional and cognitive-related phenotypes. Read More

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http://dx.doi.org/10.1038/s41386-019-0346-3DOI Listing
February 2019

Neurological recovery following traumatic spinal cord injury: a systematic review and meta-analysis.

J Neurosurg Spine 2019 Feb 15:1-17. Epub 2019 Feb 15.

1Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences.

OBJECTIVEPredicting neurological recovery following traumatic spinal cord injury (TSCI) is a complex task considering the heterogeneous nature of injury and the inconsistency of individual studies. This study aims to summarize the current evidence on neurological recovery following TSCI by use of a meta-analytical approach, and to identify injury, treatment, and study variables with prognostic significance.METHODSA literature search in MEDLINE and EMBASE was performed, and studies reporting follow-up changes in American Spinal Injury Association (ASIA) Impairment Scale (AIS) or Frankel or ASIA motor score (AMS) scales were included in the meta-analysis. Read More

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http://dx.doi.org/10.3171/2018.10.SPINE18802DOI Listing
February 2019

Recurrent and persistent carpal tunnel syndrome: predicting clinical outcome of revision surgery.

J Neurosurg 2019 Feb 15:1-9. Epub 2019 Feb 15.

1Department of Plastic & Reconstructive Surgery, Radboud University Medical Center, Nijmegen.

OBJECTIVEThe aim of this study was to evaluate the self-reported outcome of revision surgery in patients with recurrent and persistent carpal tunnel syndrome (CTS) and to identify predictors of clinical outcome of revision surgery.METHODSA total of 114 hands in 112 patients were surgically treated for recurrent and persistent CTS in one of 10 specialized hand clinics. As part of routine care, patients were asked to complete online questionnaires regarding demographic data, comorbidities, and clinical severity measures. Read More

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http://dx.doi.org/10.3171/2018.11.JNS182598DOI Listing
February 2019

dl-3-n-butylphthalide for alleviation of neurological deficit after combined extracranial-intracranial revascularization for moyamoya disease: a propensity score-matched analysis.

J Neurosurg 2019 Feb 15:1-13. Epub 2019 Feb 15.

1Department of Neurosurgery, Peking University International Hospital.

OBJECTIVEPostoperative neurological deficits impair the overall outcome of revascularization surgery for patients with moyamoya disease (MMD). dl-3-n-butylphthalide (NBP) is approved for the treatment of ischemic stroke in China. This pilot study evaluated the effect of NBP on perioperative stroke and neurological deficits in patients with MMD. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182152DOI Listing
February 2019

Improved survival of glioblastoma patients treated at academic and high-volume facilities: a hospital-based study from the National Cancer Database.

J Neurosurg 2019 Feb 15:1-12. Epub 2019 Feb 15.

1The Vivian L. Smith Department of Neurosurgery, The University of Texas Health Science Center at Houston McGovern Medical School.

OBJECTIVEThe present study was designed to explore the association between facility type (academic center [AC] vs non-AC), facility volume (high-volume facility [HVF] vs low-volume facility [LVF]), and outcomes of glioblastoma (GBM) treatment.METHODSBased on the National Cancer Database (NCDB), GBM patients were categorized by treatment facility type (non-AC vs AC) and volume [4 categories (G1-G4): < 5.0, 5. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182247DOI Listing
February 2019

Outcomes in different age groups with primary Ewing sarcoma of the spine: a systematic review of the literature.

J Neurosurg Spine 2019 Feb 15:1-10. Epub 2019 Feb 15.

4Division of Neurosurgery, University of Arizona, Tucson; and.

OBJECTIVEEwing sarcoma (ES) is among the most prevalent of bone sarcomas in young people. Less often, it presents as a primary lesion of the spine (5%-15% of patients with ES).METHODSA systematic literature search was performed, querying several scientific databases per PRISMA guidelines. Read More

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http://dx.doi.org/10.3171/2018.10.SPINE18795DOI Listing
February 2019

Encore careers: a solution to the unmet need in global neurosurgical care.

J Neurosurg 2019 Feb 15:1-3. Epub 2019 Feb 15.

3George Washington University School of Medicine and Health Sciences, Washington, DC.

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http://dx.doi.org/10.3171/2018.11.JNS183298DOI Listing
February 2019

Correlation between fractional anisotropy changes in the targeted ventral intermediate nucleus and clinical outcome after transcranial MR-guided focused ultrasound thalamotomy for essential tremor: results of a pilot study.

J Neurosurg 2019 Feb 15:1-6. Epub 2019 Feb 15.

1Faculty of Advanced Techno-Surgery and.

OBJECTIVEThis study evaluated changes of fractional anisotropy (FA) in the ventral intermediate nucleus (VIM) of the thalamus after transcranial MR-guided focused ultrasound (TcMRgFUS) thalamotomy and their associations with clinical outcome.METHODSClinical and radiological data of 12 patients with medically refractory essential tremor (mean age 76.5 years) who underwent TcMRgFUS thalamotomy with VIM targeting were analyzed retrospectively. Read More

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http://dx.doi.org/10.3171/2018.10.JNS18993DOI Listing
February 2019

Clinical characteristics of and treatment protocol for trapped temporal horn following resection of lateral ventricular trigone meningioma: a single-center experience.

J Neurosurg 2019 Feb 15:1-10. Epub 2019 Feb 15.

1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing; and.

OBJECTIVETrapped temporal horn (TTH) is a rare subtype of loculated hydrocephalus that is often managed surgically. The natural history of TTH is not well understood, and there are few data on the outcomes of conservative management of this condition. The aim of this study was to analyze the clinical features and outcomes of conservatively and surgically managed cases of TTH. Read More

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http://dx.doi.org/10.3171/2018.11.JNS182710DOI Listing
February 2019

Letter to the Editor. The career of an academic neurosurgeon: back to the future.

J Neurosurg 2019 Feb 15:1-2. Epub 2019 Feb 15.

3Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.3171/2018.11.JNS183259DOI Listing
February 2019

Rear Admiral (Astronaut) Alan Shepard: Ménière's disease and the race to the moon.

J Neurosurg 2019 Feb 15:1-7. Epub 2019 Feb 15.

6Department of Neurosurgery, University of South Alabama, Mobile, Alabama.

On May 5, 1961, Alan B. Shepard Jr. piloted the Freedom 7 craft into a suborbital flight to become the first American man in space. Read More

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http://dx.doi.org/10.3171/2018.9.JNS182522DOI Listing
February 2019

Reinfection rates following adherence to Infectious Diseases Society of America guideline recommendations in first cerebrospinal fluid shunt infection treatment.

J Neurosurg Pediatr 2019 Feb 15:1-9. Epub 2019 Feb 15.

Departments of1Pediatrics and.

OBJECTIVECSF shunt infection treatment requires both surgical and antibiotic decisions. Using the Hydrocephalus Clinical Research Network (HCRN) Registry and 2004 Infectious Diseases Society of America (IDSA) guidelines that were not proactively distributed to HCRN providers, the authors previously found high adherence to surgical recommendations but poor adherence to intravenous (IV) antibiotic duration recommendations. In general, IV antibiotic duration was longer than recommended. Read More

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http://dx.doi.org/10.3171/2018.11.PEDS18373DOI Listing
February 2019

Validation of a methodology for neuro-urological and lumbosacral stimulation studies in domestic pigs: a humanlike animal model.

J Neurosurg Spine 2019 Feb 15:1-11. Epub 2019 Feb 15.

7Neurosurgery, Pellegrin Hospital, Bordeaux, Nouvelle Aquitaine; and.

OBJECTIVESpinal cord injuries (SCIs) result in loss of movement and sensory feedback, but also organ dysfunction. Nearly all patients with complete SCI lose bladder control and are prone to kidney failure if intermittent catheterization is not performed. Electrical stimulation of sacral spinal roots was initially considered to be a promising approach for restoring continence and micturition control, but many patients are discouraged by the need for surgical deafferentation as it could lead to a loss of sensory functions and reflexes. Read More

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http://dx.doi.org/10.3171/2018.11.SPINE18676DOI Listing
February 2019

Vascular smooth muscle-MAPK14 is required for neointimal hyperplasia by suppressing VSMC differentiation and inducing proliferation and inflammation.

Redox Biol 2019 Feb 6;22:101137. Epub 2019 Feb 6.

Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, United States. Electronic address:

Injury-induced stenosis is a serious vascular complication. We previously reported that p38α (MAPK14), a redox-regulated p38MAPK family member was a negative regulator of the VSMC contractile phenotype in vitro. Here we evaluated the function of VSMC-MAPK14 in vivo in injury-induced neointima hyperplasia and the underlying mechanism using an inducible SMC-MAPK14 knockout mouse line (iSMC-MAPK14). Read More

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http://dx.doi.org/10.1016/j.redox.2019.101137DOI Listing
February 2019

Associations of blood levels of trace elements and heavy metals with metabolic syndrome in Chinese male adults with microRNA as mediators involved.

Environ Pollut 2019 Feb 6;248:66-73. Epub 2019 Feb 6.

Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, PR China. Electronic address:

Metabolic syndrome (MetS) is a global health problem with an increasing prevalence. However, effects of trace elements and heavy metals on MetS and the mechanism underlying this effect are poorly understood. A preliminary cross-sectional study was conducted in 2015. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.02.015DOI Listing
February 2019

Patent ductus arteriosus and small for gestational age infants: Treatment approaches and outcomes.

Early Hum Dev 2019 Feb 13;131:10-14. Epub 2019 Feb 13.

Department of Pediatrics, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Background: The current treatment approach in patent ductus arteriosus suggests the identification of high-risk infants that may benefit the most from treatment. Small for gestational age infants are a high-risk population in which the treatment approach to the patent ductus arteriosus and outcomes have not been described.

Aim: To compare the patent ductus arteriosus treatment approach and outcomes in small for gestational age and appropriate for gestational age infants. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2019.02.002DOI Listing
February 2019

Host's immune response in unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis treated by meglumine antimoniate: A case-control study of Th1 and Th2 pathways.

Int Immunopharmacol 2019 Feb 13;69:321-327. Epub 2019 Feb 13.

Dadbin Health Clinic, Kerman University of Medical Sciences, Kerman, Iran.

The objective of the present study was to compare the host's immune responses between unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis (ACL) treated by meglumine antimoniate. A case-control study was carried out in an endemic focus in Iran. Blood samples were taken from patients and peripheral blood mononuclear cells (PBMCs) were isolated. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.02.008DOI Listing
February 2019

Adjuvant androgen deprivation therapy for poor-risk, androgen receptor-positive salivary duct carcinoma.

Eur J Cancer 2019 Feb 13;110:62-70. Epub 2019 Feb 13.

Department of Medical Oncology, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, the Netherlands. Electronic address:

Aim: Salivary duct carcinoma (SDC), an aggressive subtype of salivary gland cancer, is androgen receptor (AR)-positive in 67-96% of cases. In patients with locally recurrent and metastatic (R/M) AR-positive SDC, androgen deprivation therapy (ADT) has an overall response rate of 18-64.7%. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.12.035DOI Listing
February 2019

A randomized, double-blind, placebo-controlled trial to assess the efficAcy and safety of Trimetazidine in patients with angina pectoris having been treated by percutaneous coronary intervention (ATPCI study): Rationale, design, and baseline characteristics.

Am Heart J 2019 Jan 15;210:98-107. Epub 2019 Jan 15.

Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou (HEGP), Department of Cardiology, Paris, France; Université Paris-Descartes, Paris, France; INSERM U-970, Paris, France.

Background: About 30% of angina patients have persisting symptoms despite successful revascularization and antianginal therapy. Moreover, in stable patients, percutaneous coronary intervention (PCI) does not improve survival as compared with medical therapy alone. Trimetazidine, an antianginal agent devoid of hemodynamic effect, may help reducing symptoms and improving outcomes after PCI. Read More

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http://dx.doi.org/10.1016/j.ahj.2018.12.015DOI Listing
January 2019

Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice.

J Nutr Biochem 2019 Jan 18;66:63-69. Epub 2019 Jan 18.

Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT 84112, USA. Electronic address:

Gut microbiota contributes to the biological activities of berry anthocyanins by transforming them into bioactive metabolites, and anthocyanins support the growth of specific bacteria, indicating a two-way relationship between anthocyanins and microbiota. In the present study, we tested the hypothesis that strawberry supplementation alters gut microbial ecology in diabetic db/db mice. Control (db/+) and diabetic (db/db) mice (7 weeks old) consumed standard diet or diet supplemented with 2. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2019.01.004DOI Listing
January 2019

A novel truncating mutation of dock7 gene with an early-onset non-encephalopathic epilepsy.

Seizure 2019 Jan 16;66:12-14. Epub 2019 Jan 16.

Marmara University, Medical Faculty, Department of Neuroradiology, Pendik, Istanbul, Turkey.

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http://dx.doi.org/10.1016/j.seizure.2019.01.010DOI Listing
January 2019

Assessing the localization accuracy and clinical utility of electric and magnetic source imaging in children with epilepsy.

Clin Neurophysiol 2019 Jan 31;130(4):491-504. Epub 2019 Jan 31.

Laboratory of Children's Brain Dynamics, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Fetal-Neonatal Neuroimaging Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Objective: To evaluate the accuracy and clinical utility of conventional 21-channel EEG (conv-EEG), 72-channel high-density EEG (HD-EEG) and 306-channel MEG in localizing interictal epileptiform discharges (IEDs).

Methods: Twenty-four children who underwent epilepsy surgery were studied. IEDs on conv-EEG, HD-EEG, MEG and intracranial EEG (iEEG) were localized using equivalent current dipoles and dynamical statistical parametric mapping (dSPM). Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.009DOI Listing
January 2019

Impaired prefrontal cortex-thalamus pathway in intractable temporal lobe epilepsy with aberrant executive control function: MRI evidence.

Clin Neurophysiol 2019 Jan 18;130(4):484-490. Epub 2019 Jan 18.

Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, PR China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, PR China. Electronic address:

Objectives: This study aimed to assess structural and functional connectivity alterations of the prefrontal cortex (PFC)-thalamus axis in individuals with unilateral intractable temporal lobe epilepsy (TLE) showing executive control function (ECF) impairment and to explore the potential mechanism.

Methods: Thirty-eight individuals with intractable left TLE and twenty-nine healthy controls (HCs) were recruited for diffusion tensor imaging (DTI) and resting-state fMRI (rs-fMRI) scanning. According to the ECF state, patients were assigned to normal and impaired ECF groups. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.007DOI Listing
January 2019

Risk factors for pelvic and distant recurrence in locally advanced cervical cancer.

Eur J Obstet Gynecol Reprod Biol 2019 Feb 6;235:6-12. Epub 2019 Feb 6.

Medical Oncology Department, A.C. Camargo Cancer Center, São Paulo, SP, Brazil. Electronic address:

Objective: Despite the benefits of concomitant radiotherapy and cisplatin for locally advanced cervical cancer, recurrence rates remain high. New treatment strategies such as consolidation chemotherapy and different concomitant chemotherapy combinations have been tested in recent years. Identification of the best candidates for each treatment strategy could optimize results. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.01.028DOI Listing
February 2019

Depth of anesthesia measured by bispectral index and postoperative mortality: A meta-analysis of observational studies.

J Clin Anesth 2019 Feb 13;56:119-125. Epub 2019 Feb 13.

Department of Anesthesiology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China. Electronic address:

Introduction: Whether anesthesia depth affects postoperative mortality remains uncertain.

Measurements: Several databases were systematically searched to identify all articles studying the relationship between depth of anesthesia and postoperative mortality. Post hoc subgroup analyses were conducted for follow-up period (30 days vs. Read More

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http://dx.doi.org/10.1016/j.jclinane.2019.01.046DOI Listing
February 2019

Iterative fully convolutional neural networks for automatic vertebra segmentation and identification.

Med Image Anal 2019 Feb 12;53:142-155. Epub 2019 Feb 12.

Image Sciences Institute, University Medical Center Utrecht, Room Q.02.4.45, 3508 GA Utrecht, P.O. Box 85500, The Netherlands.

Precise segmentation and anatomical identification of the vertebrae provides the basis for automatic analysis of the spine, such as detection of vertebral compression fractures or other abnormalities. Most dedicated spine CT and MR scans as well as scans of the chest, abdomen or neck cover only part of the spine. Segmentation and identification should therefore not rely on the visibility of certain vertebrae or a certain number of vertebrae. Read More

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http://dx.doi.org/10.1016/j.media.2019.02.005DOI Listing
February 2019

Prognostic effect of serum BDNF levels in late-life depression: Moderated by childhood trauma and SSRI usage?

Psychoneuroendocrinology 2019 Feb 7;103:276-283. Epub 2019 Feb 7.

University of Groningen, University Medical Center Groningen, Department of Psychiatry, University of Groningen PO Box 72, 9700 AB, Groningen, the Netherlands.

Background: Brain-derived neurotrophic factor (BDNF) levels decline during depression and normalise after remission, although studies in older patient samples are inconsistent. Whether BDNF serum levels predict depression remission is unclear. We hypothesize that the predictive value of serum BDNF levels in late-life depression is moderated by selective serotonin reuptake inhibitors (SSRI) usage and early traumatization. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.02.003DOI Listing
February 2019

Temporal and geographical variations in colorectal cancer incidence in Northern Iran 2004-2013.

Cancer Epidemiol 2019 Feb 13;59:143-147. Epub 2019 Feb 13.

Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Genetic Epidemiology Group, Folkhälsan Research Center, Faculty of Medicine, Helsinki University, Helsinki, Finland; Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.

Introduction: Colorectal cancer (CRC) is one of the most common cancers in the Golestan province, Northern Iran. The purpose of this study is to describe colorectal cancer incidence patterns and trends in the province 2004-2013.

Methods: Data on CRC cases were obtained from the Golestan Population-based Cancer Registry (GPCR). Read More

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http://dx.doi.org/10.1016/j.canep.2019.02.003DOI Listing
February 2019

Contemporary trends of pelvic lymph node dissection at radical cystectomy for urothelial carcinoma of urinary bladder and associated cancer specific mortality and complications: comparison between octogenarian versus younger patients.

Cancer Epidemiol 2019 Feb 13;59:135-142. Epub 2019 Feb 13.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Québec, Canada; Division of Urology, University of Montreal Hospital Center (CHUM), Montreal, Quebec, Canada.

Background: We analysed contemporary pelvic lymph node dissection (PLND) trend during radical cystectomy (RC) for urothelial carcinoma of urinary bladder (UCUB), as well as PLND association with cancer specific mortality (CSM) and complications after stratification according to octogenarian vs. younger age.

Materials And Methods: Within the SEER and NIS databases, respectively 10,427 (T2 and T3 stages) and 19,203 (all T-stages) RC patients (2004-2015) for UCUB were identified. Read More

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http://dx.doi.org/10.1016/j.canep.2019.02.002DOI Listing
February 2019

Worldwide variation in Pseudomonas associated ventilator associated pneumonia. A meta-regression.

Authors:
James C Hurley

J Crit Care 2019 Feb 6;51:88-93. Epub 2019 Feb 6.

Department of Rural Health, Melbourne Medical School, University of Melbourne, Internal Medicine Service, Ballarat Health Services, Victoria, Australia. Electronic address:

Purpose: The objective here is to define the extent and possible reasons for geographic variation in Pseudomonas aeruginosa associated with Ventilator Associated Pneumonia (VAP).

Methods: A random effects meta-regression model of Pseudomonas associated VAP incidence within the published literature was undertaken incorporating group level factors such trauma admission, year of publication and use of bronchoscopic sampling towards VAP diagnosis.

Results: Pseudomonas associated VAP incidence was reported in 162 studies from seven worldwide regions published over 30 years. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.001DOI Listing
February 2019

Unfractionated Heparin Alleviates Sepsis-Induced Acute Lung Injury by Protecting Tight Junctions.

J Surg Res 2019 Feb 13;238:175-185. Epub 2019 Feb 13.

Department of Critical Care Medicine, The First Affiliated Hospital, China Medical University, Shenyang, People's Republic of China. Electronic address:

Background: Unfractionated heparin (UFH) has been shown to ameliorate lung edema and lung vascular leakage in lipopolysaccharide-induced lung injury. Impaired tight junction (TJ) function is a sign of sepsis-induced acute respiratory distress syndrome (ARDS) and acute lung injury (ALI), which is closely related to the downregulated expression of TJ-specific proteins or the upregulated expression of inflammatory cytokines. Because UFH has been intensively studied in modulating inflammation, we hypothesize that UFH may play a positive role in treating sepsis-induced ARDS/ALI by protecting TJs. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.020DOI Listing
February 2019

Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial).

J Surg Res 2019 Feb 13;238:164-174. Epub 2019 Feb 13.

Division of Vascular and Endovascular Surgery, Department of Surgery, University of California, San Francisco, California. Electronic address:

Background: N-3 polyunsaturated fatty acid (PUFA) supplementation has been associated with reduced mortality and inflammation in patients with cardiovascular disease. There are limited data on the effects of n-3 PUFA supplementation in patients with peripheral artery disease (PAD).

Materials And Methods: The OMEGA-PAD II trial was a double-blinded, randomized, placebo-controlled trial to assess the effect of 3 mo of high-dose oral n-3 PUFA supplementation on inflammation, endothelial function, and walking ability in patients with PAD. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.038DOI Listing
February 2019

Intrahepatic Delivery of Pegylated Catalase Is Protective in a Rat Ischemia/Reperfusion Injury Model.

J Surg Res 2019 Feb 13;238:152-163. Epub 2019 Feb 13.

The COPPER Laboratory, The Ohio State University Wexner Medical Center, Columbus, Ohio; Comprehensive Transplant Center, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address:

Background: Ischemia/reperfusion injury (IRI) can occur during liver surgery. Endogenous catalase is important to cellular antioxidant defenses and is critical to IRI prevention. Pegylation of catalase (PEG-CAT) improves its therapeutic potential by extending plasma half-life, but systemic administration of exogenous PEG-CAT has been only mildly therapeutic for hepatic IRI. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.028DOI Listing
February 2019

Factors Influencing Colon and Rectal Surgery Residency Program Selection.

J Surg Res 2019 Feb 13;238:137-143. Epub 2019 Feb 13.

Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota.

Background: Little information exists to help colon and rectal surgery residency programs determine which factors applicants find important when selecting a training program. Our aim was to identify factors applicants find pertinent in the selection of their desired colon and rectal surgery residency program.

Methods: After the 2016 and 2017 National Resident Matching Program (The Match), a 58-question anonymous web-based survey was sent to all trainees who applied to our colon and rectal surgery residency program to determine factors applicants find important in selecting colon and rectal surgery residency training programs. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.042DOI Listing
February 2019

SELDI-TOF MS Analysis of Hepatocellular Carcinoma in an Australian Cohort.

J Surg Res 2019 Feb 13;238:127-136. Epub 2019 Feb 13.

Cancer Surgery and Metabolism Research Group, University of Sydney, Kolling Institute of Medical Research, St Leonards, NSW, Australia; Upper GI Surgical Unit, Royal North Shore Hospital and North Shore Private Hospital, St Leonards, NSW, Australia; Discipline of Surgery, The University of Sydney, Camperdown, NSW, Australia.

Background: Hepatocellular carcinoma (HCC) is a common cause of cancer death worldwide. Resection offers the best chance of long-term survival, but a consistent adverse prognostic factor is the presence of microvascular invasion (MVI). In this study, surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS), a high throughput method of analyzing complex samples, was used to explore differentially expressed proteins between HCC and adjacent nontumour liver tissue (ANLT). Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.008DOI Listing
February 2019

Perpetration of sexual aggression among adolescents in South Africa.

J Adolesc 2019 Feb 13;72:32-36. Epub 2019 Feb 13.

Department of Psychiatry and Mental Health, Alpert Medical School of Brown University; Providence/Boston Center for AIDS Research, USA.

Introduction: In South Africa, one in three men have reported perpetrating rape. Adolescence presents a unique developmental period for primary prevention of violence. However, few studies characterize the epidemiology of sexual violence among adolescents in South Africa. Read More

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http://dx.doi.org/10.1016/j.adolescence.2019.02.002DOI Listing
February 2019

Chronic exposure to microcystin-LR reduces thyroid hormone levels by activating p38/MAPK and MEK/ERK signal pathway.

Ecotoxicol Environ Saf 2019 Feb 13;173:142-148. Epub 2019 Feb 13.

Department of Geriatric Endocrinology, Geriatric Hospital of Nanjing Medical University, Luojia Road 30, Nanjing 210024, China. Electronic address:

Microcystin-LR (MC-LR) is the most toxic and abundant microcystin that produced by cyanobacteria. Previous studies have shown MC-LR had acute toxic to thyroid, however, the mechanism is still unclear, and the effect of long-term, low-dose MC-LR on thyroid remains uncertain. In this study, we investigated the chronic, low-dose effect of MC-LR on mouse thyroid tissues and thyroid hormone metabolism. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.024DOI Listing
February 2019

Identification and characterization of unknown degradation impurities in beclomethasone dipropionate cream formulation using HPLC, ESI-MS and NMR.

J Pharm Biomed Anal 2019 Feb 10;167:123-131. Epub 2019 Feb 10.

Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung City, Taiwan; Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan. Electronic address:

The present study focuses on identifying the degradation profile and pathways of unknown impurities from beclomethasone dipropionate (BDP) topical cream formulation reported under accelerated stability conditions. Six degradation impurities were observed during the accelerated stability testing of BDP topical cream formulation, and these thermally labile degradation impurities were primarily identified using a simple, effective and mass compatible isocratic reversed-phase high-performance liquid chromatography with ultraviolet detection method. The degradation impurities found in this sample were of very low concentration levels, thus the concentration of these impurities in the sample was enriched by mimicking the thermal degradation conditions to structurally elucidate the unknown impurities. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.02.013DOI Listing
February 2019

Utility of Likert scale (Deauville criteria) in assessment of Chemoradiotherapy response of primary oropharyngeal squamous cell Cancer site.

Clin Imaging 2019 Jan 16;55:89-94. Epub 2019 Jan 16.

Department of Radiology, Division of Nuclear Medicine, University of Minnesota Medical Center, Minneapolis, MN, USA. Electronic address:

Introduction: The aim of this study is to determine whether Likert scale (Deauville criteria) can be used to classify oropharyngeal squamous cell cancer (OPSCC) patients as 'responders' and 'nonresponders' by utilizing FDG-PET/CT for primary tumor site. The second aim is to compare the performance of methods used in interpretation of posttreatment PET/CT scans (Likert scale, SUVmax, ratios of SUVmax primary lesion to mediastinum 'SUVmax P/M' and SUVmax primary lesion to liver 'SUVmax P/L') in predicting treatment response.

Methods: Seventy-seven PET/CT scans were assessed by Deauville criteria, five-point Likert scale. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.01.007DOI Listing
January 2019

Depression is associated with diabetes status of family members: NHANES (1999-2016).

J Affect Disord 2019 Feb 6;249:121-126. Epub 2019 Feb 6.

School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China. Electronic address:

Background: The majority of the studies in this area focus on the psychological impact of having diabetic children or adolescents on parents, while a limited number of studies have investigated the effect of diabetes on the mental health status of family members in the general population. Thus, the aim of the current study is to explore the possible association between mental health disorders (depression, anxiety and panic) and diabetes status of family members among a national sample of adults in the United States.

Methods: Our analysis included 1,787 and 25,574 participants in the National Health and Nutrition Examination Survey (NHANES) 1999-2004 and 2005-2016, respectively. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.019DOI Listing
February 2019

Tuberculosis screening for prospective migrants to high-income countries: systematic review of policies.

Public Health 2019 Feb 13;168:142-147. Epub 2019 Feb 13.

King's College London, School of Population Health and Environmental Sciences, London, UK.

Objective: To compare predeparture tuberculosis (TB) screening policies, including screening criteria and screening tests, and visa requirements for prospective migrants to high-income countries that have low to intermediate TB incidence and high immigration.

Study Design: Systematic review of policy documents.

Methods: We systematically identified high-income, high net-migration countries with an estimated TB incidence of <30 per 100,000. Read More

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http://dx.doi.org/10.1016/j.puhe.2018.12.016DOI Listing
February 2019

Ecotoxicological effects of traffic-related pollutants in roadside soils of Moscow.

Ecotoxicol Environ Saf 2019 Feb 13;172:538-546. Epub 2019 Feb 13.

Faculty of Soil Science, Lomonosov Moscow State University, bld. 1/12, Leninskie Gory, Moscow 119991, Russia.

The objective of this research is to find correlations between traffic-related contaminants in the roadside soils and their ecotoxicity. The study was conducted in Moscow in the vicinity of a highway of 125 000 vehicles per day. The topsoils (0-3 cm depth) were sampled perpendicular to the road at 1-, 6-, 10-, 18- and 50-m distances from the roadbed. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.068DOI Listing
February 2019

Comparison of TSNAs concentration in saliva according to type of tobacco smoked.

Environ Res 2018 Dec 6;172:73-80. Epub 2018 Dec 6.

Group of Evaluation of Health Determinants and Health Policies, Department of Basic Sciences, Universitat Internacional de Catalunya, Carrer de Josep Trueta s/n, 08195 Sant Cugat del Vallès, Barcelona, Spain; Tobacco Control Unit, Cancer Prevention and Control Program, Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain; Cancer Prevention and Control Group, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address:

Objective: To compare tobacco-specific nitrosamines (TSNAs) measured in saliva according to different types of tobacco smoked in a sample of smokers of the city of Barcelona (Spain).

Methods: We used data from a cross-sectional study of a sample of the adult smoking population of Barcelona, Spain in 2013-2014 (n = 165). We classified smokers in five groups according to the type of tobacco smoked: a) manufactured cigarettes only, b) roll-your-own (RYO) cigarettes only, c) dual smokers (both manufactured and RYO cigarettes), d) manufactured plus other types of tobacco products different from RYO and e) other types of tobacco products different from manufactured and RYO cigarettes. Read More

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http://dx.doi.org/10.1016/j.envres.2018.12.006DOI Listing
December 2018

A rare case of transient left ventricular apical ballooning syndrome following living donor liver transplantation: A case report and literature review.

Int J Surg Case Rep 2019 Feb 10;55:218-222. Epub 2019 Feb 10.

Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address:

Introduction: Transient Left Ventricular Apical Balloon Syndrome (LV-ABS) is an unknown acute dysfunction of the left ventricle, which develops under emotional or physical stress events like the major surgical postoperative period.

Presentation Of Case: A 68-year-old woman diagnosed with hepatitis C cirrhosis was admitted for living donor liver transplantation (LDLT). No evidence for underlying cardiac or pulmonary disease was found. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193006
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http://dx.doi.org/10.1016/j.ijscr.2019.02.002DOI Listing
February 2019

Mediastinal, retroperitoneal, and subcutaneous emphysema due to sigmoid colon penetration: A case report and literature review.

Int J Surg Case Rep 2019 Feb 10;55:213-217. Epub 2019 Feb 10.

Department of Acute Care Surgery, Shimane University, Faculty of Medicine, Shimane, Japan.

Introduction: Mediastinal and subcutaneous emphysema usually result from spontaneous rupture of the alveolar wall. We present an extremely rare case of massive mediastinal, retroperitoneal, and subcutaneous emphysema due to the penetration of the colon into the mesentery.

Presentation Of Case: A 57-year-old man presented to our institution with a history of chest pain. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.02.003DOI Listing
February 2019

Exploring anxiety sensitivity in the relationship between pain intensity and opioid misuse among opioid-using adults with chronic pain.

J Psychiatr Res 2019 Feb 8;111:154-159. Epub 2019 Feb 8.

Department of Psychology, University of Houston, USA; Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, USA; HEALTH Institute, University of Houston, USA. Electronic address:

Opioid misuse is a significant public health problem. Chronic pain is one highly prevalent factor that is strongly associated with increased risk for opioid misuse. Anxiety sensitivity (fear of anxiety related physical sensations) is an individual difference factor consistently linked to pain experience, and separately, heroin use. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.02.004DOI Listing
February 2019

Clinical and genetic analysis of children with a dual diagnosis of Tourette syndrome and autism spectrum disorder.

J Psychiatr Res 2019 Feb 7;111:145-153. Epub 2019 Feb 7.

Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada. Electronic address:

Gilles de la Tourette Syndrome (TS) is a neurodevelopmental disorder that causes children to make repeated, brief involuntary movements or sounds. TS can be co-morbid with other neurodevelopmental disorders, including autism spectrum disorder (ASD). Clusters of biologically related genes have been associated with neurodevelopmental disorders, suggesting shared pathologies. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.023DOI Listing
February 2019

A pilot investigation of neuroimaging predictors for the benefits from pivotal response treatment for children with autism.

J Psychiatr Res 2019 Feb 5;111:140-144. Epub 2019 Feb 5.

Department of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Stanford, CA, 94305, USA. Electronic address:

Children with autism spectrum disorder (ASD) frequently exhibit language delays and functional communication deficits. Pivotal response treatment (PRT) is an effective intervention for targeting these skills; however, similar to other behavioral interventions, response to PRT is variable across individuals. Thus, objective markers capable of predicting treatment response are critically-needed to identify which children are most likely to benefit from this intervention. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.02.001DOI Listing
February 2019

TFAP2C-Activated MALAT1 Modulates the Chemoresistance of Docetaxel-Resistant Lung Adenocarcinoma Cells.

Mol Ther Nucleic Acids 2019 Jan 18;14:567-582. Epub 2019 Jan 18.

Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu 210002, China. Electronic address:

Chemoresistance remains a great obstacle in effective lung adenocarcinoma (LUAD) treatment. Previously, we verified the role of microRNA-200b (miR-200b) in the formation of docetaxel (DTX)-resistant LUAD cells. This study aims to investigate the mechanism underlying the low level of miR-200b in DTX-resistant LUAD cells. Read More

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http://dx.doi.org/10.1016/j.omtn.2019.01.005DOI Listing
January 2019

The effects of a childbirth preparation course on birth outcomes among nulliparous Jordanian women.

Midwifery 2019 Feb 7;72:23-29. Epub 2019 Feb 7.

Faculty of Nursing, Jordan University of Science and Technology, B.O. Box 3030, Irbid 22110, Jordan. Electronic address:

Objective: This study aimed to examine the effectiveness of a childbirth preparation course on birth outcomes among nulliparous Jordanian women.

Design: A randomized control trial pre-test/post-test design was used to assess the effects of a childbirth preparation course conducted in a military hospital in Amman, Jordan from 1 July to 15 September 2016. A total of 133 low-risk nulliparous women were recruited and randomly assigned to either (1) a control group who received standard care in antenatal clinics or (2) an intervention group who received standard care in antenatal clinics as well as a childbirth preparation course specifically designed for the purpose of this study. Read More

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http://dx.doi.org/10.1016/j.midw.2019.02.002DOI Listing
February 2019
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