3,927 results match your criteria Mediators of Inflammation [Journal]


Association of Genetic Variants of , , and with Ankylosing Spondylitis Clinical Features in Taiwanese.

Mediators Inflamm 2019 20;2019:8029863. Epub 2019 Mar 20.

Attending Physician, Department of Medicine, Division of Allergy, Immunology and Rheumatology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taiwan.

Ankylosing spondylitis (AS) is a chronic inflammatory disease that leads to spinal ankylosis. The receptor activator of the nuclear factor-kappa (RANK), RANK ligand, and osteoprotegerin (OPG) (RANK/RANKL/OPG) pathway plays critical roles in bone metabolism and the immune system. The current study was aimed at investigating whether six single-nucleotide polymorphisms (SNPs) within the , , and genes essential for bone homeostasis are associated with AS. Read More

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http://dx.doi.org/10.1155/2019/8029863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446096PMC

Association between Irisin, hs-CRP, and Metabolic Status in Children and Adolescents with Type 2 Diabetes Mellitus.

Mediators Inflamm 2019 20;2019:6737318. Epub 2019 Mar 20.

Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. Morones Prieto 3000, Monterrey, N.L. 64710, Mexico.

Proinflammatory cytokines and the novel myokine irisin, a cleavage product of FNDC5, have been found to play a role in obesity and type 2 diabetes mellitus (T2DM). Irisin has been shown to increase browning of adipose tissue, thermogenesis, energy expenditure, and insulin sensitivity, yet its association with inflammatory markers is still limited. Circulating irisin has been found to be increased in obesity, while in adult subjects with T2DM decreased levels have been found. Read More

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http://dx.doi.org/10.1155/2019/6737318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446111PMC

PPAR- Activation Exerts an Anti-inflammatory Effect by Suppressing the NLRP3 Inflammasome in Spinal Cord-Derived Neurons.

Mediators Inflamm 2019 13;2019:6386729. Epub 2019 Mar 13.

Department of Orthopedics of Guangzhou Red Cross Hospital, Medical College, Jinan University, Tongfu Road 396, 107, 510120 Guangzhou, China.

Persistent inflammation disrupts functional recovery after spinal cord injury (SCI). Peroxisome proliferator-activated receptor gamma (PPAR-) activation promotes functional recovery in SCI rats by inhibiting inflammatory cascades and increasing neuronal survival. We sought to clarify the relationship between PPAR- activation and NACHT, LRR and PYD domain-containing protein 3 (NLRP3) inflammasome suppression, and the role of NF-B in activating the NLRP3 inflammasome in neurons. Read More

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http://dx.doi.org/10.1155/2019/6386729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444263PMC

FTY720 Effects on Inflammation and Liver Damage in a Rat Model of Renal Ischemia-Reperfusion Injury.

Mediators Inflamm 2019 20;2019:3496836. Epub 2019 Mar 20.

Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, Maryland, USA.

Objective: Ischemia-reperfusion injury (IRI) produces systemic inflammation with the potential for causing organ failure in tissues peripheral to the initial site of injury. We speculate that treatment strategies that dampen inflammation may be therapeutically beneficial to either the initial site of injury or peripheral organs. To test this, we evaluated the impact of FTY720-induced sequestration of circulating mature lymphocytes on renal IRI and secondary organ injury. Read More

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http://dx.doi.org/10.1155/2019/3496836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446098PMC

High-Fat Diet Alters Immunogenic Properties of Circulating and Adipose Tissue-Associated Myeloid-Derived CD45DDR2 Cells.

Mediators Inflamm 2019 28;2019:1648614. Epub 2019 Feb 28.

Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC 29401, USA.

Chronic inflammation is evident in the adipose tissue and periphery of patients with obesity, as well as mouse models of obesity. T cell subsets in obese adipose tissue are skewed towards Th1- and Th17-associated phenotypes and their secreted cytokines contribute to obesity-associated inflammation. Our lab recently identified a novel, myeloid-derived CD45DDR2 cell subset that modulates T cell activity. Read More

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https://www.hindawi.com/journals/mi/2019/1648614/
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http://dx.doi.org/10.1155/2019/1648614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421777PMC
February 2019
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Dynamic Profile of CD4 T-Cell-Associated Cytokines/Chemokines following Murine Myocardial Infarction/Reperfusion.

Mediators Inflamm 2019 18;2019:9483647. Epub 2019 Mar 18.

Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200092, China.

CD4 T-cells play crucial roles in the injured heart. However, the way in which different CD4 T subtypes function in the myocardial infarction/reperfusion (MI/R) heart is still poorly understood. We aimed to detect the dynamic profile of distinct CD4 subpopulation-associated cytokines/chemokines by relying on a closed-chest acute murine MI/R model. Read More

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https://www.hindawi.com/journals/mi/2019/9483647/
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http://dx.doi.org/10.1155/2019/9483647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442492PMC
March 2019
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Production of Soluble Receptor Activator of Nuclear Factor Kappa-Β Ligand and Osteoprotegerin by Apical Periodontitis Cells in Culture and Their Modulation by Cytokines.

Mediators Inflamm 2019 18;2019:8325380. Epub 2019 Mar 18.

Medical Faculty of the Military Medical Academy, Belgrade, Serbia.

RANKL, a bone-destructive cytokine, and OPG, its osteoprotective counterpart, are expressed in periapical lesions (PLs), which represent hystopatological manifestations of apical periodontitis. However, their regulation in PLs has not been elucidated yet. Therefore, our aim was to study the production of RANKL and OPG and their modulation by pro- and anti-inflammatory cytokines in PL cell cultures. Read More

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http://dx.doi.org/10.1155/2019/8325380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442274PMC

Preoperative Sleep Disturbance Exaggerates Surgery-Induced Neuroinflammation and Neuronal Damage in Aged Mice.

Mediators Inflamm 2019 18;2019:8301725. Epub 2019 Mar 18.

Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, China.

Postoperative cognitive dysfunction (POCD) is defined as new cognitive impairment (memory impairment and impaired performance) after surgery, especially in aged patients. Sleep disturbance is a common phenomenon before surgery that has been increasingly thought to affect patient recovery. However, little is known about the functional impact of preoperative sleep disturbance on POCD. Read More

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http://dx.doi.org/10.1155/2019/8301725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442479PMC

The Differential Expression of Mitochondrial Function-Associated Proteins and Antioxidant Enzymes during Bovine Herpesvirus 1 Infection: A Potential Mechanism for Virus Infection-Induced Oxidative Mitochondrial Dysfunction.

Mediators Inflamm 2019 18;2019:7072917. Epub 2019 Mar 18.

Key Laboratory for Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, Henan Province 450002, China.

Reactive oxidative species (ROS) are important inflammatory mediators. Electrons escaping from the mitochondrial electron transport chain (ETC) during oxidative phosphorylation (OXPHOS) in the mitochondrial respiratory chain (RC) complexes contribute to ROS production. The cellular antioxidant enzymes are important for maintaining ROS release at the physiological levels. Read More

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http://dx.doi.org/10.1155/2019/7072917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442485PMC

Apoptosis Transcriptional Profile Induced by HmuY.

Mediators Inflamm 2019 18;2019:6758159. Epub 2019 Mar 18.

Department of Immunology, Federal University of Bahia, Bahia, Brazil.

This study aimed at evaluating the transcriptional profile of apoptosis-related genes after stimulation of peripheral blood mononuclear cells (PBMCs) derived from individuals with periodontitis (P) and healthy nonperiodontitis (NP) control subjects with HmuY protein. PBMCs from the P and NP groups were stimulated with HmuY protein, and the expression of genes related to apoptosis was assessed by custom real-time polymerase chain reaction array (Custom RT PCR Array). Compared with the NP group, the P group showed low relative levels of apoptosis-related gene expression, downregulated for FAS, FAS ligand, TNFSF10 (TRAIL), BAK1, CASP9, and APAF1 after HmuY protein stimulation. Read More

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http://dx.doi.org/10.1155/2019/6758159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442302PMC

Dysregulated T Cell Activation and Aberrant Cytokine Expression Profile in Systemic Lupus Erythematosus.

Mediators Inflamm 2019 17;2019:8450947. Epub 2019 Mar 17.

Clinical Research Center, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.

Accumulating evidence indicates a critical role for T cells and relevant cytokines in the pathogenesis of systemic lupus erythematosus (SLE). However, the specific contribution of T cells together with the related circulating cytokines in disease pathogenesis and organ involvement is still not clear. In the current study, we investigated relevant molecule expressions and cytokine levels in blood samples from 49 SLE patients and 22 healthy control subjects. Read More

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http://dx.doi.org/10.1155/2019/8450947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441516PMC

The Reduced Expression of EOLA1 May Be Related to Refractory Diabetic Foot Ulcer.

Mediators Inflamm 2019 17;2019:6705424. Epub 2019 Mar 17.

Department of Endocrinology, First Affiliated Hospital of Army Medical University (Third Military Medical University), Chongqing 400038, China.

Background: Chronic diabetic foot ulcer (DFU) is one of the most intractable complications of diabetes mellitus (DM). Its pathogenesis is complex, and uncontrolled chronic inflammation is an important factor. Endothelial overexpressed lipopolysaccharide-associated factor 1 (EOLA1) discovered in our laboratory is an intracellular protein with the function of inflammatory regulation. Read More

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http://dx.doi.org/10.1155/2019/6705424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441532PMC

Anti-Atopic Dermatitis Effect of Extract via Inhibiting the STAT1 Pathway.

Mediators Inflamm 2019 17;2019:3760934. Epub 2019 Mar 17.

Department of Pharmacology, College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do 26339, Republic of Korea.

(SF) is a green alga rich in chlorophyll with unique flavor and taste. It is also called Maesaengi which has antioxidant and other physiological activities. In the present study, we evaluated the therapeutic effects of SF in a mouse model of body-induced atopic dermatitis (AD) and in tumor necrosis factor- and interferon--stimulated HaCaT keratinocytes. Read More

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http://dx.doi.org/10.1155/2019/3760934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441517PMC

Effect of Propofol on the Production of Inflammatory Cytokines by Human Polarized Macrophages.

Mediators Inflamm 2019 17;2019:1919538. Epub 2019 Mar 17.

Department of Anesthesiology and Pain Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

Macrophages are key immune system cells involved in inflammatory processes. Classically activated (M1) macrophages are characterized by strong antimicrobicidal properties, whereas alternatively activated (M2) macrophages are involved in wound healing. Severe inflammation can induce postoperative complications during the perioperative period. Read More

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http://dx.doi.org/10.1155/2019/1919538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441544PMC

Role of Inflammation in the Pathogenesis of Diverticular Disease.

Mediators Inflamm 2019 14;2019:8328490. Epub 2019 Mar 14.

Gastroenterology Unit, ASL Roma 6, Albano Laziale, Roma, Italy.

Diverticulosis of the colon is the most common condition in Western societies and it is the most common anatomic alteration of the human colon. Recurrent abdominal pain is experienced by about 20% of patients with diverticulosis, but the pathophysiologic mechanisms of its occurrence are not completely understood. In the last years, several fine papers have showed clearly the role of low-grade inflammation both in the occurrence of symptoms in people having diverticulosis, both in symptom persistence following acute diverticulitis, even if the evidence available is not so strong. Read More

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http://dx.doi.org/10.1155/2019/8328490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437747PMC
March 2019
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Progressive Increase of Inflammatory CXCR4 and TNF-Alpha in the Dorsal Root Ganglia and Spinal Cord Maintains Peripheral and Central Sensitization to Diabetic Neuropathic Pain in Rats.

Mediators Inflamm 2019 14;2019:4856156. Epub 2019 Mar 14.

Department of Anaesthesiology, The University of Hong Kong, HKSAR, China.

Diabetic neuropathic pain (DNP) is a common and serious complication of diabetic patients. The pathogenesis of DNP is largely unclear. The proinflammation proteins, CXCR4, and TNF- play critical roles in the development of pain, while their relative roles in the development of DNP and especially its progression is unknown. Read More

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http://dx.doi.org/10.1155/2019/4856156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437743PMC

The Effect of Taxifolin on Cisplatin-Induced Pulmonary Damage in Rats: A Biochemical and Histopathological Evaluation.

Mediators Inflamm 2019 12;2019:3740867. Epub 2019 Mar 12.

Department of Nursing, Faculty of Health Sciences, Erzincan Binali Yildirim University, Erzincan, Turkey.

The effect of taxifolin on cisplatin-induced oxidative pulmonary damage was investigated biochemically and histopathologically in male albino Wistar rats. There were four groups, with six animals in each group: 50 mg/kg of taxifolin plus 2.5 mg/kg of cisplatin (TC) group, 2. Read More

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http://dx.doi.org/10.1155/2019/3740867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434269PMC

Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents.

Mediators Inflamm 2019 10;2019:8968943. Epub 2019 Mar 10.

Centre for Inflammation Research, School of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH16 4TJ, UK.

Neutrophils are the most abundant leukocytes in peripheral blood and respond rapidly to danger, infiltrating tissues within minutes of infectious or sterile injury. Neutrophils were long thought of as simple killers, but now we recognise them as responsive cells able to adapt to inflammation and orchestrate subsequent events with some sophistication. Here, we discuss how these rapid responders release mediators which influence later adaptive T cell immunity through influences on DC priming and directly on the T cells themselves. Read More

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https://www.hindawi.com/journals/mi/2019/8968943/
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http://dx.doi.org/10.1155/2019/8968943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431490PMC
March 2019
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Erratum to "Increased Expression of TLR10 in B Cell Subsets Correlates with Disease Activity in Rheumatoid Arthritis".

Mediators Inflamm 2019 10;2019:8419439. Epub 2019 Mar 10.

School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.

[This corrects the article DOI: 10.1155/2018/9372436.]. Read More

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http://dx.doi.org/10.1155/2019/8419439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431516PMC
March 2019
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Correlation between Plasma Macrophage Migration Inhibitory Factor Levels and Long-Term Prognosis in Patients with Acute Myocardial Infarction Complicated with Diabetes.

Mediators Inflamm 2019 7;2019:8276180. Epub 2019 Mar 7.

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China.

Macrophage migration inhibitory factor (MIF), a widely expressed pleiotropic cytokine, is reportedly involved in several cardiovascular diseases, in addition to inflammatory diseases. Plasma MIF levels are elevated in the early phase of acute cardiac infarction. This study is aimed at investigating the correlation between plasma MIF levels and cardiac function and prognosis in patients with acute ST-segment elevation myocardial infarction (STEMI) with or without diabetes mellitus. Read More

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http://dx.doi.org/10.1155/2019/8276180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431529PMC

Effects of the Highly COX-2-Selective Analgesic NSAID Etoricoxib on Human Periodontal Ligament Fibroblasts during Compressive Orthodontic Mechanical Strain.

Mediators Inflamm 2019 10;2019:2514956. Epub 2019 Mar 10.

Department of Orthodontics, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.

Human periodontal ligament (hPDL) fibroblasts play a major role during periodontitis and orthodontic tooth movement, mediating periodontal inflammation, osteoclastogenesis, and collagen synthesis. The highly COX-2-selective NSAID etoricoxib has a favorable systemic side effect profile and high analgesic efficacy, particularly for orthodontic pain. In this in vitro study, we investigated possible side effects of two clinically relevant etoricoxib concentrations on the expression pattern of mechanically strained hPDL fibroblasts and associated osteoclastogenesis in a model of simulated orthodontic compressive strain occurring during orthodontic tooth movement. Read More

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http://dx.doi.org/10.1155/2019/2514956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431464PMC
March 2019
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Exploring the Involvement of NLRP3 and IL-1 in Osteoarthritis of the Hand: Results from a Pilot Study.

Mediators Inflamm 2019 10;2019:2363460. Epub 2019 Mar 10.

Northern Ireland Centre for Stratified Medicine, University of Ulster, Biomedical Sciences, Research Institute, Londonderry, UK.

Hand osteoarthritis (HOA) includes different subsets; a particular and uncommon form is erosive HOA (EHOA). Interleukin- (IL-) 1 plays a crucial role in the pathogenesis of osteoarthritis (OA); it is synthesized as an inactive precursor which requires the intervention of a cytosolic multiprotein complex, named inflammasome, for its activation. The aim of this study was to investigate the involvement of IL-1 and the NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome in patients with EHOA and nonerosive HOA (NEHOA) compared to healthy controls. Read More

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https://www.hindawi.com/journals/mi/2019/2363460/
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http://dx.doi.org/10.1155/2019/2363460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431515PMC
March 2019
1 Read

Inflammation as a Target in Cancer Therapy.

Mediators Inflamm 2019;2019:1971698. Epub 2019 Mar 7.

Unidad de Biomedicina. Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México (UNAM), Av. De los Barrios 1, Los Reyes Iztacala, Tlalnepantla, Edo. De México 54090, Mexico.

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http://dx.doi.org/10.1155/2019/1971698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431488PMC

Circulating Monocyte and Lymphocyte Populations in Healthy First-Degree Relatives of Type 2 Diabetic Patients at Fasting and during Short-Term Hyperinsulinemia.

Mediators Inflamm 2019 11;2019:1491083. Epub 2019 Mar 11.

Department of Pathophysiology, Third Faculty of Medicine, Charles University, Prague 100 00, Czech Republic.

Aim: The development of type 2 diabetes (T2DM) is associated with disturbances of immune status that may be reflected by alterations of the profile of circulating immune cells. In order to study whether there exists genetic predisposition to these alterations, we investigated the relative content of circulating monocyte and lymphocyte subpopulations at fasting condition and upon stimulation by short-term hyperinsulinemia in nondiabetic first-degree relatives (FDR) of T2DM patients and in control subjects.

Materials And Methods: 19 nondiabetic (FDR) and 19 control subjects without a family history of diabetes (all men) matched for age and BMI underwent 2-hour hyperinsulinemic-euglycemic clamp. Read More

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http://dx.doi.org/10.1155/2019/1491083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432732PMC

Cx43 Inhibition Attenuates Sepsis-Induced Intestinal Injury via Downregulating ROS Transfer and the Activation of the JNK1/Sirt1/FoxO3a Signaling Pathway.

Mediators Inflamm 2019 5;2019:7854389. Epub 2019 Mar 5.

Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Intestinal injury has long been considered to play a crucial role in the pathophysiology of sepsis and has even been characterized as the "motor" of it. Thus, we explored the effects of connexin43 (Cx43) on sepsis-induced intestinal injury in order to provide potential therapeutic strategies. Rat cecal ligation and puncture (CLP) models and cell models (IEC-6 cells) pretreated with LPS were used in the current study. Read More

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http://dx.doi.org/10.1155/2019/7854389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425293PMC

Response to: Comment on "Analysis of Microarray-Identified Genes and MicroRNAs Associated with Idiopathic Pulmonary Fibrosis".

Mediators Inflamm 2019 4;2019:3192089. Epub 2019 Mar 4.

Department of Pathology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.

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http://dx.doi.org/10.1155/2019/3192089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425360PMC
March 2019
2 Reads

Huang Qi Tong Bi Decoction Attenuates Myocardial Ischemia-Reperfusion Injury via HMGB1/TLR/NF-B Pathway.

Mediators Inflamm 2019 3;2019:8387636. Epub 2019 Mar 3.

Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, China.

The aim of this study was to study the protective effect of Huang Qi Tong Bi Decoction (HQTBT) on the heart of rats. Ischemia-reperfusion injury was established by coronary artery ligation. Proinflammatory cytokines were decreased by XFZY in coronary artery ligated rats. Read More

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http://dx.doi.org/10.1155/2019/8387636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421754PMC

The Liver X Receptor Is Upregulated in Monocyte-Derived Macrophages and Modulates Inflammatory Cytokines Based on LXR Polymorphism.

Mediators Inflamm 2019 28;2019:6217548. Epub 2019 Feb 28.

Department of Rheumatology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 16499, Republic of Korea.

Liver X receptors (LXRs) have emerged as important regulators of inflammatory gene expression. Previously, we had reported that an LXR gene promoter polymorphism (-1830 T > C) is associated with systemic lupus erythematosus (SLE). Therefore, we assessed cytokine expression in relation to LXR polymorphism in monocyte-derived macrophages from patients with SLE. Read More

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http://dx.doi.org/10.1155/2019/6217548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421810PMC
February 2019
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Soluble Receptor for Advanced Glycation End Products: A Protective Molecule against Intramyocardial Lipid Accumulation in Obese Zucker Rats?

Mediators Inflamm 2019 28;2019:2712376. Epub 2019 Feb 28.

Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.

Most of the obesity-related complications are due to ectopic fat accumulation. Recently, the activation of the cell-surface receptor for advanced glycation end products (RAGE) has been associated with lipid accumulation in different organs. Nevertheless, the role of RAGE and sRAGE, the soluble form that prevents ligands to activate RAGE, in intramyocardial lipid accumulation is presently unknown. Read More

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http://dx.doi.org/10.1155/2019/2712376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421753PMC
February 2019
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Association of Platelet Binding to Lymphocytes with B Cell Abnormalities and Clinical Manifestations in Systemic Lupus Erythematosus.

Mediators Inflamm 2019 3;2019:2473164. Epub 2019 Mar 3.

Department of Immunology, Biomedical Research Institute Sant Pau (IBB Sant Pau), Barcelona, Spain.

Systemic lupus erythematosus (SLE) is an autoimmune disease associated with the polyclonal activation of B lymphocytes and the production of autoantibodies that cause immune complex-related inflammation. Immunological factors derived from platelets modulate B cell function in SLE disease. However, platelets do not only modify the immune system by soluble factors. Read More

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http://dx.doi.org/10.1155/2019/2473164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421767PMC
March 2019
3 Reads

How Adhesion Molecule Patterns Change While Neutrophils Traffic through the Lung during Inflammation.

Mediators Inflamm 2019 28;2019:1208086. Epub 2019 Feb 28.

Department of Anesthesiology and Intensive Care Medicine, Hospital of Bayreuth, Germany.

In acute pulmonary inflammation, polymorphonuclear cells (PMNs) pass a transendothelial barrier from the circulation into the lung interstitium followed by a transepithelial migration into the alveolar space. These migration steps are regulated differentially by a concept of adhesion molecules and remain-despite decades of research-incompletely understood. Current knowledge of changes in the expression pattern of adhesion molecules mainly derives from in vitro studies or from studies in extrapulmonary organ systems, where regulation of adhesion molecules differs significantly. Read More

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http://dx.doi.org/10.1155/2019/1208086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421765PMC
February 2019

Contribution of Statins towards Periodontal Treatment: A Review.

Mediators Inflamm 2019 27;2019:6367402. Epub 2019 Feb 27.

INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France.

The pleiotropic effects of statins have been evaluated to assess their potential benefit in the treatment of various inflammatory and immune-mediated diseases including periodontitis. Herein, the adjunctive use of statins in periodontal therapy , , and in clinical trials was reviewed. Statins act through several pathways to modulate inflammation, immune response, bone metabolism, and bacterial clearance. Read More

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http://dx.doi.org/10.1155/2019/6367402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415285PMC
February 2019
11 Reads

Hepcidin and Iron Homeostasis in Patients with Subacute Thyroiditis and Healthy Subjects.

Mediators Inflamm 2019 27;2019:5764061. Epub 2019 Feb 27.

Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poland.

Purpose: Hepcidin is an acute-phase protein involved also in regulation of iron homeostasis. The aim of the study was to prospectively assess for the first time the hepcidin concentration in patients with subacute thyroiditis (SAT), to identify biochemical determinants of hepcidin concentration and evaluate the potential role of hepcidin in SAT diagnosis and monitoring.

Methods: Out of 40 patients with SAT initially recruited, restrictive inclusion criteria fulfilled 21 subjects aged 45 ± 10 years and 21 healthy control subjects (CS). Read More

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http://dx.doi.org/10.1155/2019/5764061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415316PMC
February 2019
6 Reads

Immune Dysfunction and Albumin-Related Immunity in Liver Cirrhosis.

Mediators Inflamm 2019 25;2019:7537649. Epub 2019 Feb 25.

Department of Gastroenterology, Hepatology and Infectious Diseases, University Magdeburg, Leipzigerstrasse 44, 39120 Magdeburg, Germany.

Liver cirrhosis yearly causes 1.2 million deaths worldwide, ranking as the 10th leading cause of death in the most developed countries. High susceptibility to infections along with a significant risk for infection-related mortality justifies the description of liver cirrhosis as the world's most common immunodeficiency syndrome. Read More

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http://dx.doi.org/10.1155/2019/7537649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410448PMC
February 2019
2 Reads

miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years.

Mediators Inflamm 2019 24;2019:6714080. Epub 2019 Feb 24.

Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.

Introduction: Alterations in miR-155 serum levels have been described in inflammatory and infectious diseases. Moreover, a role for miR-155 in aging and age-related diseases was recently suggested. We therefore analyzed a potential age-dependent prognostic value of circulating miR-155 as a serum-based marker in critical illness. Read More

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http://dx.doi.org/10.1155/2019/6714080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409014PMC
February 2019

Ginsenoside Rg1 Regulates SIRT1 to Ameliorate Sepsis-Induced Lung Inflammation and Injury via Inhibiting Endoplasmic Reticulum Stress and Inflammation.

Mediators Inflamm 2019 24;2019:6453296. Epub 2019 Feb 24.

Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha 410078, China.

Objectives: To investigate the protective effect of ginsenoside Rg1 on relieving sepsis-induced lung inflammation and injury and .

Methods: Cultured human pulmonary epithelial cell line A549 was challenged with LPS to induce cell injury, and CLP mouse model was generated to mimic clinical condition of systemic sepsis. Rg1 was applied to cells or animals at indicated dosage. Read More

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http://dx.doi.org/10.1155/2019/6453296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409002PMC
February 2019
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PG102 Upregulates IL-37 through p38, ERK, and Smad3 Pathways in HaCaT Keratinocytes.

Mediators Inflamm 2019 24;2019:6085801. Epub 2019 Feb 24.

ViroMed Co. Ltd., Building 203, Seoul National University, Seoul 151-742, Republic of Korea.

IL-37 is an immunomodulatory cytokine that suppresses inflammation in various cell types and disease models. However, its role in keratinocytes has not been clearly understood, and there has been no report on the agents that can increase the expression of IL-37 in keratinocytes. In this study, we investigated the effects of silencing in HaCaT keratinocytes and the molecular mechanisms involved in the upregulation of IL-37 by PG102, a water-soluble extract from . Read More

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http://dx.doi.org/10.1155/2019/6085801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409045PMC
February 2019

Angiotensin-(1-7) and Alamandine Promote Anti-inflammatory Response in Macrophages and .

Mediators Inflamm 2019 21;2019:2401081. Epub 2019 Feb 21.

Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.

The renin-angiotensin system (RAS) peptides play an important role in inflammation. Resolution of inflammation contributes to restore tissue homeostasis, and it is characterized by neutrophil apoptosis and their subsequent removal by macrophages, which are remarkable plastic cells involved in the pathophysiology of diverse inflammatory diseases. However, the effects of RAS peptides on different macrophage phenotypes are still emerging. Read More

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http://dx.doi.org/10.1155/2019/2401081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409041PMC
February 2019

Cytokines and Chemokines in Pediatric Appendicitis: A Multiplex Analysis of Inflammatory Protein Mediators.

Mediators Inflamm 2019 21;2019:2359681. Epub 2019 Feb 21.

Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary AB, Canada.

Objectives: We aimed to demonstrate the potential of precision medicine to describe the inflammatory landscape present in children with suspected appendicitis. Our primary objective was to determine levels of seven inflammatory protein mediators previously associated with intra-abdominal inflammation (C-reactive protein-CRP, procalcitonin-PCT, interleukin-6 (IL), IL-8, IL-10, monocyte chemoattractant protein-1-MCP-1, and serum amyloid A-SAA) in a cohort of children with suspected appendicitis. Subsequently, using a multiplex proteomics approach, we examined an expansive array of novel candidate cytokine and chemokines within this population. Read More

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http://dx.doi.org/10.1155/2019/2359681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409077PMC
February 2019
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CEMP-1 Levels in Periodontal Wound Fluid during the Early Phase of Healing: Prospective Clinical Trial.

Mediators Inflamm 2019 24;2019:1737306. Epub 2019 Feb 24.

Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Via Mangiagalli 31, 20133 Milan, Italy.

Objectives: Cementogenesis seems to be significantly compromised during tissue inflammation. In dental practice, surgical procedures are performed with the aim to regenerate periodontium including cementum. However, inflammation that occurs during the initial healing phases after surgery may impair regeneration of this tissues. Read More

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https://www.hindawi.com/journals/mi/2019/1737306/
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http://dx.doi.org/10.1155/2019/1737306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409030PMC
February 2019
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Immune Mediator Profile in Aqueous Humor Differs in Patients with Primary Acquired Ocular Toxoplasmosis and Recurrent Acute Ocular Toxoplasmosis.

Mediators Inflamm 2019 17;2019:9356728. Epub 2019 Feb 17.

Department of Ophthalmology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Germany.

Purpose: To compare the intraocular cytokine and chemokine profiles in patients with acute primary acquired ocular toxoplasmosis (pOT) or recurrent ocular toxoplasmosis (rOT) and to correlate them with their clinical characteristics.

Methods: Aqueous humor samples were collected from 62 consecutive patients (21 pOT, 30 rOT, and 11 noninfected controls) and analyzed by multiplex assay. Correlations were assessed between cytokine/chemokine levels, type of inflammatory response (T1, T2, and T17), and clinical characteristics. Read More

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https://www.hindawi.com/journals/mi/2019/9356728/
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http://dx.doi.org/10.1155/2019/9356728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398019PMC
February 2019
10 Reads

Matrix Metalloproteinase-9-Dependent Release of IL-1 by Human Eosinophils.

Mediators Inflamm 2019 17;2019:7479107. Epub 2019 Feb 17.

University of Wisconsin-Madison School of Medicine and Public Health, Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Madison, WI, USA.

Asthma is often associated with airway eosinophilia, and therapies targeting eosinophils are now available to treat severe eosinophilic asthma. Eosinophilic asthma is often due to a type-2 immune response and production of IL-5, which leads to eosinophilopiesis and recruitment of mature eosinophils in the airways. A concomitant type-2 and type-17 response has been reported in some individuals. Read More

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http://dx.doi.org/10.1155/2019/7479107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398033PMC
February 2019
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NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs.

Mediators Inflamm 2019 13;2019:6847087. Epub 2019 Feb 13.

Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001 Heilongjiang, China.

Increasing evidence suggests that the NLRP3 (nucleotide oligomerization domain-like receptor family, pyrin domain containing 3) inflammasome participates in cardiovascular diseases. However, its role and activation mechanism during hypertension remains unclear. In this study, we tested the role and mechanism of calcium-sensing receptor (CaSR) in NLRP3 inflammasome activation during hypertension. Read More

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https://www.hindawi.com/journals/mi/2019/6847087/
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http://dx.doi.org/10.1155/2019/6847087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393924PMC
February 2019
3 Reads

Flemingia philippinensis Flavonoids Relieve Bone Erosion and Inflammatory Mediators in CIA Mice by Downregulating NF-B and MAPK Pathways.

Mediators Inflamm 2019 17;2019:5790291. Epub 2019 Feb 17.

Biotechnology College, Guilin Medical University, Guilin. Guangxi, China.

Background: The dry root of Flemingia philippinensis has been widely used in the treatment of rheumatism, arthropathy, and osteoporosis in traditional Chinese medicine; the therapeutic effects of Flemingia philippinensis are associated with antiarthritis in traditional Chinese medicine theory. This study was undertaken to investigate the mechanism of bone erosion protection and anti-inflammatory effect of Flemingia philippinensis flavonoids (FPF) in collagen-induced arthritis (CIA) in mice.

Methods: Flavonoids were extracted from the dry root of Flemingia philippinensis. Read More

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http://dx.doi.org/10.1155/2019/5790291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397971PMC
February 2019
4 Reads

Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-B and CaSR.

Mediators Inflamm 2019 19;2019:1082497. Epub 2019 Feb 19.

Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou 121001, China.

Long-term exposure to high glucose induces vascular endothelial inflammation that can result in cardiovascular disease. Astragaloside IV (As-IV) is widely used for anti-inflammatory treatment of cardiovascular diseases. However, its mechanism of action is still not fully understood. Read More

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http://dx.doi.org/10.1155/2019/1082497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398021PMC
February 2019
3 Reads

Melatonin Inhibits Lipopolysaccharide-Induced Inflammation and Oxidative Stress in Cultured Mouse Mammary Tissue.

Mediators Inflamm 2019 12;2019:8597159. Epub 2019 Feb 12.

Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.

To determine whether melatonin can protect cultured mouse mammary tissue from lipopolysaccharide- (LPS-) induced damage, we investigated the effects of melatonin on the mRNA and protein levels of proinflammatory cytokines and chemokines in LPS-stimulated mammary tissue . This study also examined the IgG level in both cultured mammary tissue and the culture medium. In addition, we investigated the potential benefits of melatonin on the expression of antioxidant relative genes following LPS treatment in cultured mammary tissue and evaluated ROS level in the culture medium. Read More

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http://dx.doi.org/10.1155/2019/8597159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390262PMC
February 2019

Are There Any Common Genetic Risk Markers for Rheumatoid Arthritis and Periodontal Diseases? A Case-Control Study.

Mediators Inflamm 2019 12;2019:2907062. Epub 2019 Feb 12.

Department of Operative Dentistry and Periodontology, Martin Luther University Halle-Wittenberg, Germany.

Background: Several studies suggest that there is a biologically plausible connection between rheumatoid arthritis (RA) and periodontal diseases (PD). Both disorders are characterized as multifactorial diseases potentially sharing common risk factors. Based on the inflammatory nature of RA and PD, the impact of genetic variations of genes of the immune system on both diseases was studied in this study. Read More

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http://dx.doi.org/10.1155/2019/2907062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390239PMC
February 2019
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Relation of Macrophage Migration Inhibitory Factor to Pulmonary Hemodynamics and Vascular Structure and Carbamyl-Phosphate Synthetase I Genetic Variations in Pediatric Patients with Congenital Cardiac Shunts.

Mediators Inflamm 2019 6;2019:7305028. Epub 2019 Feb 6.

Heart Institute, University of São Paulo School of Medicine, São Paulo 05403-000, Brazil.

Macrophage migration inhibitory factor (MIF) plays an important pathophysiological role in pulmonary hypertension (PHT). Previously, we demonstrated that serum MIF is increased in pediatric PHT associated with congenital heart disease (CHD). In the present study, we determined possible associations between MIF levels, hemodynamic and histological parameters, and mitochondrial carbamyl-phosphate synthetase I (CPSI) T1405N polymorphism in a similar population. Read More

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http://dx.doi.org/10.1155/2019/7305028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381580PMC
February 2019
1 Read

Inflammatory and Fibrotic Mediators in Renal Diseases.

Mediators Inflamm 2019;2019:7025251. Epub 2019 Feb 10.

Cellular Biology in Renal Diseases Laboratory, Universidad Autónoma Madrid, IIS-Fundación Jiménez Díaz, Madrid, Spain.

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http://dx.doi.org/10.1155/2019/7025251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387726PMC
February 2019

Inhibition of Cerebral High-Mobility Group Box 1 Protein Attenuates Multiple Organ Damage and Improves T Cell-Mediated Immunity in Septic Rats.

Mediators Inflamm 2019 10;2019:6197084. Epub 2019 Feb 10.

School of Medicine, Nankai University, Tianjin 300071, China.

Sepsis remains one of the leading causes of mortality in intensive care units, but there is a shortage of effective treatments. A dysregulated host immune response and multiple organ injury are major factors for the pathogenesis and progression of sepsis, which require specific mechanism and treatment. In the present study, we performed an intracerebroventricular (ICV) injection of BoxA, a specific antagonist of high-mobility group box 1 protein (HMGB1), in septic rats that were produced by cecal ligation and puncture surgery; we further assessed the functional changes of multiple organs and splenic T lymphocytes. Read More

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http://dx.doi.org/10.1155/2019/6197084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387733PMC
February 2019