3,855 results match your criteria Mediators of Inflammation [Journal]


Mediators of Inflammation in Topical Therapy of Skin Cancers.

Mediators Inflamm 2019 10;2019:8369690. Epub 2019 Jan 10.

Carol Davila University of Medicine and Pharmacy Bucharest, Romania, Bucharest, Romania.

Taking into consideration that the immune system plays a very important role in the development of melanoma and non-melanoma skin cancers, which have a high prevalence in immunosuppressed patients and after prolonged ultraviolet radiation, the interest in developing novel therapies, in particular targeting the inflammation in cancer, has increased in the past years. The latest data suggest that therapies such as imiquimod (IMQ), ingenol mebutate (IM), 5-fluorouracil (5-FU), retinoids, and nonsteroidal anti-inflammatory drugs (NSAIDs) have been used with success in the topical treatment of some cancers. Herein, we review the topical treatment targeting the inflammation in skin cancer and the mechanisms involved in these processes. Read More

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http://dx.doi.org/10.1155/2019/8369690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350587PMC
January 2019

Chronic Rhinosinusitis without Nasal Polyps in Asian Patients Shows Mixed Inflammatory Patterns and Neutrophil-Related Disease Severity.

Mediators Inflamm 2019 15;2019:7138643. Epub 2019 Jan 15.

Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Republic of Korea.

Chronic rhinosinusitis (CRS) shows heterogeneous immunologic features. Western studies revealed that CRS without nasal polyps (CRSsNP) showed a predominantly type 1 immune response and CRS with nasal polyps (CRSwNP) was characterized by type 2 immune response; however, the detailed immunologic profile of CRSsNP in Asian patients has not been thoroughly investigated. Therefore, we investigated the inflammatory endotypes of CRSsNP in Asian patients. Read More

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http://dx.doi.org/10.1155/2019/7138643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350559PMC
January 2019

iNKT Cell Activation Exacerbates the Development of Huntington's Disease in R6/2 Transgenic Mice.

Mediators Inflamm 2019 15;2019:3540974. Epub 2019 Jan 15.

Department of Integrative Bioscience and Biotechnology, Institute of Anticancer Medicine Development, Sejong University, Seoul 05006, Republic of Korea.

Huntington's disease (HD) is an inherited neurodegenerative disorder which is caused by a mutation of the huntingtin (HTT) gene. Although the pathogenesis of HD has been associated with inflammatory responses, if and how the immune system contributes to the onset of HD is largely unknown. Invariant natural killer T (iNKT) cells are a group of innate-like regulatory T lymphocytes that can rapidly produce various cytokines such as IFN and IL4 upon stimulation with the glycolipid -galactosylceramide (-GalCer). Read More

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http://dx.doi.org/10.1155/2019/3540974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350536PMC
January 2019

Chemokines and Growth Factors Produced by Lymphocytes in the Incompetent Great Saphenous Vein.

Mediators Inflamm 2019 10;2019:7057303. Epub 2019 Jan 10.

School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Department of Microbiology and Immunology, Jordana 19, 41-808 Zabrze, Poland.

The role of cytokines in the pathogenesis of chronic venous disease (CVD) remains obscure. It has been postulated that oscillatory flow present in incompetent veins causes proinflammatory changes. Our earlier study confirmed this hypothesis. Read More

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https://www.hindawi.com/journals/mi/2019/7057303/
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http://dx.doi.org/10.1155/2019/7057303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348837PMC
January 2019
2 Reads

CD4 TSCMs in the Bone Marrow Assist in Maturation of Antibodies against Influenza in Mice.

Mediators Inflamm 2019 10;2019:3231696. Epub 2019 Jan 10.

Shenzhen Luohu People's Hospital, The Third Affiliated Hospital of Shenzhen University, Shenzhen 518001, China.

The bone marrow (BM) is not only a reservoir of hematopoietic stem cells but a repository of immunological memory cells. Further characterizing BM-resident memory T cells would be helpful to reveal the complicated relationship between the BM and immunological memory. In this study, we identified CD122 stem cell antigen-1 (Sca-1) B cell lymphoma 2 (Bcl-2) CD4 stem cell-like memory T cells (TSCMs) as a distinct memory T cell subset, which preferentially reside in the BM, where they respond vigorously to blood-borne antigens. Read More

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https://www.hindawi.com/journals/mi/2019/3231696/
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http://dx.doi.org/10.1155/2019/3231696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348795PMC
January 2019
2 Reads

Inflammasome Genes' Polymorphisms in Egyptian Chronic Hepatitis C Patients: Influence on Vulnerability to Infection and Response to Treatment.

Mediators Inflamm 2019 9;2019:3273645. Epub 2019 Jan 9.

Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Ain Helwan, Helwan, Cairo 11795, Egypt.

Chronic inflammation is a pivotal contributor to the liver damage mediated by hepatitis C virus (HCV). The NOD-like receptor, pyrin domain-containing 3 (NLRP3) inflammasome is activated by HCV in both hepatocytes and Kupffer cells. The aim of our study was to investigate the association of nine single-nucleotide polymorphisms in four inflammasome genes (NLRP3, CARD8, IL-1, and IL-18) with the susceptibility to HCV infection and outcome of interferon treatment in 201 Egyptian chronic hepatitis C patients and 95 healthy controls. Read More

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http://dx.doi.org/10.1155/2019/3273645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343134PMC
January 2019

Interleukin-37: The Effect of Anti-Inflammatory Response in Human Coronary Artery Endothelial Cells.

Mediators Inflamm 2019 8;2019:2650590. Epub 2019 Jan 8.

Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China.

Interleukin-37 (IL-37) is unique in the IL-1 family since it broadly suppresses innate immunity and elevates in humans with inflammatory and autoimmune diseases. IL-37 shows definite groups and transcripts for human IL37 gene, but it is still not completely understood the effect and mechanisms of inflammatory response in endothelial cells. It is well accepted that endothelial dysfunction caused by inflammation is a key initiating event in atherosclerotic plaque formation, which leads to the occurrence and development of the cardiovascular adverse events in clinical since the inflammatory responses of endothelial cells could induce and enhance the deposition of extensive lipid and the formation of atherosclerotic plaque in the intima. Read More

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http://dx.doi.org/10.1155/2019/2650590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341264PMC
January 2019

Inflammasomes, Autophagy, and Cell Death: The Trinity of Innate Host Defense against Intracellular Bacteria.

Authors:
Teresa Krakauer

Mediators Inflamm 2019 8;2019:2471215. Epub 2019 Jan 8.

Department of Immunology, Molecular and Translational Sciences Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702-5011, USA.

Inflammasome activation is an innate host defense mechanism initiated upon sensing pathogens or danger in the cytosol. Both autophagy and cell death are cell autonomous processes important in development, as well as in host defense against intracellular bacteria. Inflammasome, autophagy, and cell death pathways can be activated by pathogens, pathogen-associated molecular patterns (PAMPs), cell stress, and host-derived damage-associated molecular patterns (DAMPs). Read More

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http://dx.doi.org/10.1155/2019/2471215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341260PMC
January 2019
1 Read

Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure.

Mediators Inflamm 2019 8;2019:1575410. Epub 2019 Jan 8.

Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, China.

Background: Interleukin-11 (IL-11) is an important inflammatory cytokine and has been demonstrated to participate in cardiovascular diseases. However, there have been no studies about the role of IL-11 in heart failure (HF). The present study is aimed at investigating whether IL-11 levels are associated with the cardiac prognosis in patients with HF. Read More

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http://dx.doi.org/10.1155/2019/1575410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341241PMC
January 2019
3.236 Impact Factor

Mannan-Binding Lectin Suppresses Peptidoglycan-Induced TLR2 Activation and Inflammatory Responses.

Mediators Inflamm 2019 9;2019:1349784. Epub 2019 Jan 9.

School of Laboratory Medicine, Xinxiang Medical University, Xinxiang 453003, China.

Peptidoglycan (PGN), as the major components of the bacterial cell wall, is known to cause excessive proinflammatory cytokine production. Toll-like receptor 2 (TLR2) is abundantly expressed on immune cells and has been shown to be involved in PGN-induced signaling. Although more and more evidences have indicated that PGN is recognized by TLR2, the role of TLR2 PGN recognition is controversial. Read More

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http://dx.doi.org/10.1155/2019/1349784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343158PMC
January 2019
3.236 Impact Factor

Alteration in Inflammatory Responses and Cytochrome P450 Expression of Porcine Jejunal Cells by Drinking Water Supplements.

Mediators Inflamm 2019 2;2019:5420381. Epub 2019 Jan 2.

Department of Pharmacology and Toxicology, University of Veterinary Medicine, István u. 2., Budapest 1078, Hungary.

The intestinal epithelium is the first determining barrier to the drugs administered . Cytochrome P450 (CYP) enzymes are substantial in the initial step of xenobiotic metabolism; therefore, intestinal CYP enzyme activities could be an important influencing factor of the oral utilization of xenobiotic substances. In this study, the effect of four drinking water supplements on CYP mRNA levels of porcine intestinal epithelial cells was examined. Read More

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http://dx.doi.org/10.1155/2019/5420381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334367PMC
January 2019

The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis.

Mediators Inflamm 2019 3;2019:5160694. Epub 2019 Jan 3.

Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China.

Background: Acute exacerbation of IPF (AE-IPF) is associated with high mortality. We studied changes in pathogen involvement during AE-IPF and explored a possible role of infection in AE-IPF.

Objectives: Our purpose is to investigate the role of infection in AE-IPF. Read More

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https://www.hindawi.com/journals/mi/2019/5160694/
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http://dx.doi.org/10.1155/2019/5160694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335849PMC
January 2019
2 Reads
3.236 Impact Factor

Norfluoxetine Prevents Degeneration of Dopamine Neurons by Inhibiting Microglia-Derived Oxidative Stress in an MPTP Mouse Model of Parkinson's Disease.

Mediators Inflamm 2018 30;2018:4591289. Epub 2018 Dec 30.

Department of Neuroscience, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.

Neuroinflammation is the neuropathological feature of Parkinson's disease (PD) and causes microglial activation and activated microglia-derived oxidative stress in the PD patients and PD animal models, resulting in neurodegeneration. The present study examined whether norfluoxetine (a metabolite of fluoxetine) could regulate neuroinflammation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropypridine (MPTP) mouse model of PD and rescue dopamine neurons. Analysis by tyrosine hydroxylase (TH) immunohistochemistry demonstrated that norfluoxetine prevents degeneration of nigrostriatal dopamine neurons in MPTP-lesioned mice compared to vehicle-treated MPTP-lesioned control mice. Read More

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http://dx.doi.org/10.1155/2018/4591289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332876PMC
December 2018

Unravelling the Interplay between Extracellular Acidosis and Immune Cells.

Mediators Inflamm 2018 30;2018:1218297. Epub 2018 Dec 30.

Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires, CONICET, Ciudad de Buenos Aires, Argentina.

The development of an acidic tissue environment is a hallmark of a variety of inflammatory processes and solid tumors. However, little attention has been paid so far to analyze the influence exerted by extracellular pH on the immune response. Tissue acidosis (pH 6. Read More

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https://www.hindawi.com/journals/mi/2018/1218297/
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http://dx.doi.org/10.1155/2018/1218297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332927PMC
December 2018
3 Reads

Increased Expression of TLR10 in B Cell Subsets Correlates with Disease Activity in Rheumatoid Arthritis.

Mediators Inflamm 2018 27;2018:9372436. Epub 2018 Dec 27.

School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Toll-like receptor (TLR) 10, mainly expressed on B cells, has emerged as a modulatory receptor in inflammation. Nonetheless, the clinical significance of TLR10 in rheumatoid arthritis (RA) remains unclear. In this study, we explored the expression of TLR10 in B cells and B cell subsets in RA subjects and healthy controls (HCs) and determined its relevance to disease activity and inflammatory biomarkers. Read More

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http://dx.doi.org/10.1155/2018/9372436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327257PMC
December 2018

Characterization of CD4 T Cell Subsets in Patients with Abdominal Aortic Aneurysms.

Mediators Inflamm 2018 27;2018:6967310. Epub 2018 Dec 27.

Department of Clinical Pathology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo 13083-887, Brazil.

Background: The mediators produced by CD4 T lymphocytes are involved in the pathogenesis of aneurysmal lesions in abdominal aortic aneurysm (AAA) patients. The aim of this study was to identify and characterize the CD4 T cell subsets involved in human AAA.

Methods: The CD4 T cell subsets in 30 human aneurysmal lesions were determined using flow cytometry (FC) and immunohistochemistry (IHC). Read More

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http://dx.doi.org/10.1155/2018/6967310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327259PMC
December 2018

Erratum to "Molecular Responses of Human Retinal Cells to Infection with Dengue Virus".

Mediators Inflamm 2018 23;2018:9891049. Epub 2018 Dec 23.

Eye & Vision Health, Flinders University School of Medicine, Rm 4E-431, 1 Flinders Drive, Bedford Park, Adelaide, SA 5042, Australia.

[This corrects the article DOI: 10.1155/2017/3164375.]. Read More

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http://dx.doi.org/10.1155/2018/9891049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323469PMC
December 2018

The Inflammatory Response to Enterotoxigenic and Probiotic in a Coculture Model of Porcine Intestinal Epithelial and Dendritic Cells.

Mediators Inflamm 2018 20;2018:9368295. Epub 2018 Dec 20.

Institute of Veterinary Physiology, Department of Veterinary Medicine, Freie Universität Berlin, Oertzenweg 19b, 14163 Berlin, Germany.

The gut epithelium constitutes an interface between the intestinal contents and the underlying gut-associated lymphoid tissue (GALT) including dendritic cells (DC). Interactions of intestinal epithelial cells (IEC) and resident DC are characterized by bidirectional crosstalk mediated by various factors, such as transforming growth factor- (TGF-) and thymic stromal lymphopoietin (TSLP). In the present study, we aimed (1) to model the interplay of both cell types in a porcine coculture consisting of IEC (cell line IPEC-J2) and monocyte-derived DC (MoDC) and (2) to assess whether immune responses to bacteria are altered because of the interplay between IPEC-J2 cells and MoDC. Read More

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http://dx.doi.org/10.1155/2018/9368295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317115PMC
December 2018

CD3+ B-1a Cells as a Mediator of Disease Progression in Autoimmune-Prone Mice.

Mediators Inflamm 2018 23;2018:9289417. Epub 2018 Dec 23.

Department of Pediatrics, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.

B-1a cells are distinguishable from conventional B cells, which are designated B-2 cells, on the basis of their developmental origin, surface marker expression, and functions. In addition to the unique expression of the CD5 antigen, B-1a cells are characterized by the expression level of CD23. Although B-1a cells are considered to be independent of T cells and produce natural autoantibodies that induce the clinical manifestations of autoimmune diseases, there is much debate on the role of B-1a cells in the development of autoimmune diseases. Read More

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http://dx.doi.org/10.1155/2018/9289417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323491PMC
December 2018

Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage.

Mediators Inflamm 2018 23;2018:8739473. Epub 2018 Dec 23.

Cellular Biology in Renal Diseases Laboratory, Universidad Autónoma Madrid, IIS-Fundación Jiménez Díaz, Madrid, Spain.

Chronic kidney disease (CKD) is characterized by persistent inflammation and progressive fibrosis, ultimately leading to end-stage renal disease. Although many studies have investigated the factors involved in the progressive deterioration of renal function, current therapeutic strategies only delay disease progression, leaving an unmet need for effective therapeutic interventions that target the cause behind the inflammatory process and could slow down or reverse the development and progression of CKD. Epidermal growth factor receptor (EGFR) (ERBB1), a membrane tyrosine kinase receptor expressed in the kidney, is activated after renal damage, and preclinical studies have evidenced its potential as a therapeutic target in CKD therapy. Read More

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https://www.hindawi.com/journals/mi/2018/8739473/
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http://dx.doi.org/10.1155/2018/8739473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323488PMC
December 2018
6 Reads

Pharmacological Inhibition of Caspase-1 Ameliorates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation in Mice.

Mediators Inflamm 2018 23;2018:6571676. Epub 2018 Dec 23.

Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu 42472, Republic of Korea.

Caspase-1 is a proinflammatory caspase responsible for the proteolytic conversion of the precursor forms of interleukin-1 to its active form and plays an important role in the pathogenesis of various inflammatory diseases. It was reported that genetic deficiency of caspase-1 prevented cisplatin-induced nephrotoxicity. However, whether pharmacological inhibition of caspase-1 also has a preventive effect against cisplatin-induced kidney injury has not been evaluated. Read More

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http://dx.doi.org/10.1155/2018/6571676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323438PMC
December 2018

Resveratrol Suppresses Gut-Derived NLRP3 Inflammasome Partly through Stabilizing Mast Cells in a Rat Model.

Mediators Inflamm 2018 20;2018:6158671. Epub 2018 Dec 20.

Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.

Background: Inflammatory responses induced by intestinal ischemia-reperfusion (IIR) lead to serious systemic organ dysfunction and pose a challenge for current treatment. This study aimed at investigating the effects of resveratrol on IIR-induced intestinal injury and its influence on mast cells (MCs) in rats.

Methods: Rats subjected to intestinal ischemia for 60 min and 4 h of IIR were investigated. Read More

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http://dx.doi.org/10.1155/2018/6158671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317093PMC
December 2018
1 Read

Phenotypic and Functional Diversities of Myeloid-Derived Suppressor Cells in Autoimmune Diseases.

Mediators Inflamm 2018 23;2018:4316584. Epub 2018 Dec 23.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA.

Myeloid-derived suppressor cells (MDSCs) are identified as a heterogeneous population of cells with the function to suppress innate as well as adaptive immune responses. The initial studies of MDSCs were primarily focused on the field of animal tumor models or cancer patients. In cancer, MDSCs play the deleterious role to inhibit tumor immunity and to promote tumor development. Read More

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http://dx.doi.org/10.1155/2018/4316584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323474PMC
December 2018

The Effect and Mechanism of TLR9/KLF4 in FFA-Induced Adipocyte Inflammation.

Mediators Inflamm 2018 18;2018:6313484. Epub 2018 Dec 18.

Shihezi University, School of Medicine, Shihezi, Xinjiang 832000, China.

Objective: Current research has reported that obesity is a chronic inflammatory state, which is closely related with excessive accumulation of free fatty acid, while the specific mechanism that high level of FFA causes inflammation is not very clear. Thus, our research intended to observe the high FFA effects on TLR9/KLF4 expression and the downstream inflammatory factors, to explore the mechanism of inflammatory response suppressed by TLR9/KLF4.

Methods: qRT-PCR and Western blot were used to detect the mRNA and protein expression levels of TLR9, KLF4, and key inflammation-related factors. Read More

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http://dx.doi.org/10.1155/2018/6313484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312605PMC
December 2018
2 Reads
3.236 Impact Factor

Inflammatory Profiles in Depressed Adolescents Treated with Fluoxetine: An 8-Week Follow-up Open Study.

Mediators Inflamm 2018 18;2018:4074051. Epub 2018 Dec 18.

Laboratory of Psychoimmunology, National Institute of Psychiatry Ramón de la Fuente, Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 México City, Mexico.

Changes in cytokine levels in major depression and during treatment have been reported in adults. However, few studies have examined cytokine levels in an adolescent sample despite this being a common age of onset. . Read More

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http://dx.doi.org/10.1155/2018/4074051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312587PMC
December 2018
2 Reads

The Role of Circulating Regulatory T Cell Levels on Subclinical Atherosclerosis and Cardiovascular Risk Factors in Women with Systemic Lupus Erythematosus.

Mediators Inflamm 2018 18;2018:3271572. Epub 2018 Dec 18.

Laboratorios Clínicos de Puebla, Puebla, Mexico.

The increase in cardiovascular disease (CVD) in patients with systemic lupus erythematosus (SLE) is not fully explained by traditional CVD risk factors. Regulatory T cells (Treg cells) are considered atheroprotective. We investigated the relationship between the absolute number of different phenotypes of Treg cells and abnormal carotid intima-media thickness (IMT) in women with SLE. Read More

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http://dx.doi.org/10.1155/2018/3271572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312616PMC
December 2018
2 Reads

Nasal Discharge Eosinophils in Childhood Asthma Patients as a Predictive Factor for Persistent Asthma.

Mediators Inflamm 2018 18;2018:2563978. Epub 2018 Dec 18.

Murayama Pediatrics, Osaka, Japan.

Objective: Eosinophilic inflammation is thought to play a role in childhood asthma. Thus, examination of nasal eosinophils, instead of sputum, may be useful for the diagnosis of not only eosinophil-positive rhinitis but also persistent asthma. Nasal eosinophil examination is a routine for the diagnosis of nasal eosinophil-positive rhinitis in patients with rhinorrhea symptoms. Read More

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http://dx.doi.org/10.1155/2018/2563978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312575PMC
December 2018
1 Read

Polymorphisms Are Associated with Increased Risk of Developing Premature Coronary Artery Disease and with Some Cardiometabolic Parameters: The GEA Mexican Study.

Mediators Inflamm 2018 18;2018:1847696. Epub 2018 Dec 18.

Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, Mexico.

In an animal model, new evidence has been reported supporting the role of as an atherosclerosis-associated gene. Our objective was to establish if polymorphisms are associated with the risk of developing premature coronary artery disease (CAD) or with the presence of cardiometabolic parameters. After an informatic analysis, five polymorphisms were chosen and determined in 1158 patients with premature CAD and 1104 controls using 5' exonuclease TaqMan genotyping assays. Read More

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https://www.hindawi.com/journals/mi/2018/1847696/
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http://dx.doi.org/10.1155/2018/1847696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312582PMC
December 2018
3 Reads

Lepidium meyenii Walp Exhibits Anti-Inflammatory Activity against ConA-Induced Acute Hepatitis.

Mediators Inflamm 2018 16;2018:8982756. Epub 2018 Dec 16.

Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary, Academy of Military Medical Science, Changchun 130122, China.

Strong inflammation is a prominent pathogenesis of acute hepatitis, which can induce hepatocyte death and lead to liver failure. Lepidium meyenii Walp (Maca) is a traditional herbal medicine mostly used in improving sperm motility and serum hormone levels, etc. However, there are no reports that showed Maca was designed for treating hepatitis so far. Read More

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https://www.hindawi.com/journals/mi/2018/8982756/
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http://dx.doi.org/10.1155/2018/8982756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311815PMC
December 2018
4 Reads

Propofol Suppresses Proinflammatory Cytokine Production by Increasing ABCA1 Expression via Mediation by the Long Noncoding RNA LOC286367.

Mediators Inflamm 2018 17;2018:8907143. Epub 2018 Dec 17.

Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.

We previously reported that propofol upregulated the expression of ATP-binding cassette transporter subfamily A member 1 (ABCA1) via peroxisome proliferator-activated receptor gamma/liver X receptor in macrophage-derived foam cells. Here, we provide evidence that in addition to inducing ABCA1 expression, propofol represses proinflammatory cytokine production by increasing ABCA1 expression in a LOC286367-dependent manner. Western blot analysis showed that ABCA1 expression was elevated in macrophages by propofol treatment and this effect was markedly reduced by LOC286367 overexpression. Read More

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https://www.hindawi.com/journals/mi/2018/8907143/
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http://dx.doi.org/10.1155/2018/8907143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311839PMC
December 2018
4 Reads

Activation of GABA Receptor Suppresses Diabetic Neuropathic Pain through Toll-Like Receptor 4 Signaling Pathway in the Spinal Dorsal Horn.

Mediators Inflamm 2018 10;2018:6016272. Epub 2018 Dec 10.

Department of Anesthesiology, The Third Hospital of Hebei Medical University, No. 139 Ziqiang Road, Shijiazhuang 050051, China.

Diabetic neuropathic pain (DNP) is a prevalent complication in diabetes patients. Neuronal inflammation and activation of Toll-like receptor 4 (TLR4) are involved in the occurrence of DNP. However, the underlying mechanisms remain unclear. Read More

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http://dx.doi.org/10.1155/2018/6016272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311757PMC
December 2018
1 Read

Involvement of M1 Macrophage Polarization in Endosomal Toll-Like Receptors Activated Psoriatic Inflammation.

Mediators Inflamm 2018 16;2018:3523642. Epub 2018 Dec 16.

Immunology Research Center, National Health Research Institutes, Miaoli, Taiwan.

Psoriasis is a chronic inflammatory skin disorder that affects ~2%-3% of the worldwide population. Inappropriate and excessive activation of endosomal Toll-like receptors 7, 8, and 9 (TLRs 7-9) at the psoriatic site has been shown to play a pathogenic role in the onset of psoriasis. Macrophage is a major inflammatory cell type that can be differentiated into phenotypes M1 and M2. Read More

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http://dx.doi.org/10.1155/2018/3523642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311781PMC
December 2018

Grape Seed Proanthocyanidin Extract Inhibits Human Esophageal Squamous Cancerous Cell Line ECA109 via the NF-B Signaling Pathway.

Mediators Inflamm 2018 17;2018:3403972. Epub 2018 Dec 17.

Key Laboratory for Xinjiang Endemic and Ethnic Diseases, 832000, China.

Esophageal squamous cell carcinoma is the most common type of squamous cell carcinoma. Grape seed proanthocyanidin extract (GSPE) is considered to exhibit anticancer activity against several different types of cancer. We aimed to determine whether GSPE inhibited esophageal squamous cancerous cells and the possible involvement of NF-B in this process. Read More

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https://www.hindawi.com/journals/mi/2018/3403972/
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http://dx.doi.org/10.1155/2018/3403972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311955PMC
December 2018
2 Reads

A New Model Based on 25-Hydroxyvitamin D3 for Predicting Active Crohn's Disease in Chinese Patients.

Mediators Inflamm 2018 16;2018:3275025. Epub 2018 Dec 16.

Division of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Background: The association between vitamin D3 and activity of Crohn's disease (CD) is unclear in Chinese patients. In this study, we aimed to evaluate the correlations between serum levels of 25-hydroxyvitamin D3 (25(OH)D3) and disease activity and predict active disease based on vitamin D status.

Methods: Between January 2014 and December 2017, 346 CD patients from the First Affiliated Hospital of Sun Yat-sen University were recruited and categorized into a group with 25(OH)D3 ≤ 20 ng/ml and a group with 25(OH)D3 > 20 ng/ml. Read More

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http://dx.doi.org/10.1155/2018/3275025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311756PMC
December 2018
3 Reads
3.236 Impact Factor

Epigenetic Modification Mechanisms Involved in Inflammation and Fibrosis in Renal Pathology.

Mediators Inflamm 2018 13;2018:2931049. Epub 2018 Dec 13.

RedInRen RETIC, ISCIII, Spain.

The growing incidence of obesity, hypertension, and diabetes, coupled with the aging of the population, is increasing the prevalence of renal diseases in our society. Chronic kidney disease (CKD) is characterized by persistent inflammation, fibrosis, and loss of renal function leading to end-stage renal disease. Nowadays, CKD treatment has limited effectiveness underscoring the importance of the development of innovative therapeutic options. Read More

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http://dx.doi.org/10.1155/2018/2931049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311799PMC
December 2018

Metabolism Plays a Key Role during Macrophage Activation.

Mediators Inflamm 2018 10;2018:2426138. Epub 2018 Dec 10.

Centre Méditerranéen de Médecine Moléculaire-Université Côte d'Azur-INSERM U1065, Team 13, France.

Monocyte and macrophage diversity is evidenced by the modulation of cell surface markers and differential production of soluble mediators. These immune cells play key roles in controlling tissue homeostasis, infections, and excessive inflammation. Macrophages remove dead cells in a process named efferocytosis, contributing to the healthy tissue maintenance. Read More

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http://dx.doi.org/10.1155/2018/2426138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311794PMC
December 2018

Association between Brain-Derived Neurotrophic Factor (BDNF) Levels in 2 Trimester Amniotic Fluid and Fetal Development.

Mediators Inflamm 2018 5;2018:8476217. Epub 2018 Dec 5.

Second Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens Medical School, Aretaieio Hospital, Athens, Greece.

The development of the fetal nervous system mirrors general fetal development, comprising a combination of genetic resources and effects of the intrauterine environment. Our aim was to assess the 2 trimester amniotic fluid levels of brain-derived neurotrophic factor (BDNF) and to investigate its association with fetal growth. In accordance with our study design, samples of amniotic fluid were collected from women who had undergone amniocentesis early in the 2 trimester. Read More

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http://dx.doi.org/10.1155/2018/8476217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304926PMC
December 2018

Effects of Tobacco Usage and Antiretroviral Therapy on Biomarkers of Systemic Immune Activation in HIV-Infected Participants.

Mediators Inflamm 2018 9;2018:8357109. Epub 2018 Dec 9.

Department of Immunology, University of Pretoria, South Africa.

Like HIV infection, smoking, which is common among HIV-infected persons, is associated with chronic, systemic inflammation. However, the possible augmentative effects of HIV infection and smoking and other types of tobacco usage on indices of systemic inflammation and the impact of combination antiretroviral therapy (cART) thereon remain largely unexplored and represent the focus of the current study. Of the total number of HIV-infected persons recruited to the study ( = 199), 100 were categorised as pre-cART and 99 as virally suppressed (HIV viral load < 40 copies/mL). Read More

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http://dx.doi.org/10.1155/2018/8357109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304812PMC
December 2018
2 Reads

The Process of Acclimation to Chronic Hypoxia Leads to Submandibular Gland and Periodontal Alterations: An Insight on the Role of Inflammatory Mediators.

Mediators Inflamm 2018 9;2018:6794508. Epub 2018 Dec 9.

Cátedra de Fisiología, Facultad de Odontología, Universidad de Buenos Aires, Buenos Aires 1122, Argentina.

The exposition to hypoxia is a stressful stimulus, and the organism develops acclimation mechanisms to ensure homeostasis, but if this fails, it leads to the development of pathological processes. Considering the large number of people under hypoxic conditions, it is of utmost importance to study the mechanisms implicated in hypoxic acclimation in oral tissues and the possible alteration of some important inflammatory markers that regulate salivary and periodontal function. It is the aim of the present study to analyze submandibular (SMG) and periodontal status of animals chronically exposed to continuous (CCH) or intermittent (CIH) hypoxia in order to elucidate the underlying molecular mechanisms that may lead to hypoxic acclimation. Read More

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http://dx.doi.org/10.1155/2018/6794508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304881PMC
December 2018

Anti-Inflammatory Effects of through the Inhibition of NF-B, MAPK, and Akt Pathways in LPS-Stimulated RAW 264.7 Macrophages.

Mediators Inflamm 2018 29;2018:4675204. Epub 2018 Nov 29.

Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan, Republic of Korea.

is a common flower found in almost all regions of South Korea. In the current study, we investigated the potential antioxidant and anti-inflammatory properties of the methanol extract in LPS-stimulated RAW 264.7 cells. Read More

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http://dx.doi.org/10.1155/2018/4675204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304821PMC
November 2018
9 Reads
3.236 Impact Factor

Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy.

Mediators Inflamm 2018 6;2018:4231591. Epub 2018 Dec 6.

CONACYT-Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Km 4.5 Carretera Atlixco-Metepec HGZ5, Puebla 74360, Mexico.

Autophagy is a protein and organelle degradation pathway important for the maintenance of cytoplasmic homeostasis and for providing nutrients for survival in response to stress conditions. Recently, autophagy has been shown to be important for the secretion of diverse proteins involved in inflammation, intercellular signaling, and cancer progression. The role of autophagy in cancer depends on the stage of tumorigenesis, serving a tumor-suppressor role before transformation and a tumor-survival function once a tumor is established. Read More

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https://www.hindawi.com/journals/mi/2018/4231591/
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http://dx.doi.org/10.1155/2018/4231591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304875PMC
December 2018
8 Reads

The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling.

Mediators Inflamm 2018 4;2018:4032484. Epub 2018 Dec 4.

Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.

Aims: Levo-tetrahydropalmatine (L-THP) is an active ingredient of W. T. Wang, which has many bioactive properties. Read More

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http://dx.doi.org/10.1155/2018/4032484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304924PMC
December 2018
1 Read

Upregulation of Cardiac IL-10 and Downregulation of IFN- in Balb/c IL-4 in Acute Chagasic Myocarditis due to Colombian Strain of .

Mediators Inflamm 2018 28;2018:3421897. Epub 2018 Nov 28.

General Pathology, Institute of Natural and Biological Sciences, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, Brazil.

Inflammatory response in Chagas disease is related to parasite and host factors. However, immune system regulation has not been fully elucidated. Thus, this study is aimed at evaluating IL-4 influence on acute phase of experimental infection through dosage of cytokine levels in cardiac homogenate of infected Balb/c WT and Balb/c IL-4 as well as its histopathological repercussions. Read More

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http://dx.doi.org/10.1155/2018/3421897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304210PMC
November 2018
6 Reads
3.236 Impact Factor

Gut Microbiome Dysbiosis and Immunometabolism: New Frontiers for Treatment of Metabolic Diseases.

Mediators Inflamm 2018 9;2018:2037838. Epub 2018 Dec 9.

School of Arts, Sciences and Humanities (EACH), University of São Paulo, São Paulo, SP CEP 03828-000, Brazil.

Maintenance of healthy human metabolism depends on a symbiotic consortium among bacteria, archaea, viruses, fungi, and host eukaryotic cells throughout the human gastrointestinal tract. Microbial communities provide the enzymatic machinery and the metabolic pathways that contribute to food digestion, xenobiotic metabolism, and production of a variety of bioactive molecules. These include vitamins, amino acids, short-chain fatty acids (SCFAs), and metabolites, which are essential for the interconnected pathways of glycolysis, the tricarboxylic acid/Krebs cycle, oxidative phosphorylation (OXPHOS), and amino acid and fatty acid metabolism. Read More

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http://dx.doi.org/10.1155/2018/2037838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304917PMC
December 2018
4 Reads

The TGF-1 Signaling Pathway as an Attractive Target in the Fibrosis Pathogenesis of Sjögren's Syndrome.

Mediators Inflamm 2018 26;2018:1965935. Epub 2018 Nov 26.

Department of Basic Medical Sciences, Neurosciences and Sensory Organs (SMBNOS), Section of Human Anatomy and Histology, University of Bari "Aldo Moro", Bari, Italy.

Transforming growth factor 1 (TGF-1) plays a crucial role contributing to marked fibrotic changes that compromise normal organ function. The TGF-1 signal exerts its biological effects via the TGF-/SMAD/Snail signaling pathway, playing an important pathogenic role in several fibrotic diseases. It has as yet been poorly investigated in the chronic autoimmune disease Sjögren's syndrome (SS). Read More

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http://dx.doi.org/10.1155/2018/1965935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287147PMC
November 2018
1 Read

The Effect and Mechanism of KLF7 in the TLR4/NF-B/IL-6 Inflammatory Signal Pathway of Adipocytes.

Mediators Inflamm 2018 26;2018:1756494. Epub 2018 Nov 26.

Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Bei-Er-Lu, Shihezi, Xinjiang 832000, China.

Objective: To investigate the role and possible molecular mechanism of Krüppel-like factor 7 (KLF7) in the TLR4/NF-B/IL-6 inflammatory signaling pathway activated by free fatty acids (FFA).

Methods: The mRNA and protein expression levels of KLF7 and the factors of TLR4/NF-B/IL-6 inflammatory signal pathways were detected by qRT-PCR and Western blotting after cell culture with different concentrations of palmitic acid (PA). The expression of KLF7 or TLR4 in adipocytes was upregulated or downregulated; after that, the mRNA and protein expression levels of these key factors were detected. Read More

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http://dx.doi.org/10.1155/2018/1756494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287150PMC
November 2018

The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters.

Mediators Inflamm 2018 25;2018:7041342. Epub 2018 Nov 25.

Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, 4a Chodzki Street, 20-093 Lublin, Poland.

The cause of endometriosis remains unknown. However, studies investigating the link between this condition and the immune system revealed several immunological abnormalities focused on cell-mediated immunity. As a major immune checkpoint, programmed cell death protein 1 (PD-1) displays an important inhibitory function in the maintenance of peripheral tolerance. Read More

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http://dx.doi.org/10.1155/2018/7041342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286737PMC
November 2018
4 Reads

Anti-TNF- Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease.

Mediators Inflamm 2018 22;2018:3021863. Epub 2018 Nov 22.

Department of Gastroenterology, The Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China.

Neutrophils have been found to play an important role in the pathogenesis of inflammatory bowel disease (IBD), and anti-TNF- mAb (i.e., infliximab) therapy is demonstrated to be effective in the induction of clinical remission and mucosal healing in these patients. Read More

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http://dx.doi.org/10.1155/2018/3021863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282128PMC
November 2018

Immune Checkpoint Receptors Tim-3 and PD-1 Regulate Monocyte and T Lymphocyte Function in Septic Patients.

Mediators Inflamm 2018 22;2018:1632902. Epub 2018 Nov 22.

Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.

We aim to investigate the effects of Tim-3 and programmed cell death-1 (PD-1) on the monocytes and T lymphocytes in septic patients. Expression of Tim-3 and PD-1 on the CD3, CD4, and CD8 lymphocytes and monocytes was determined using flow cytometry. CBA technique was utilized to determine the expression of cytokines in the lymphocyte supernatant in addition to the IL-10 and TNF- positivity in monocytes in the presence of Tim-3 and/or PD-1 receptor blockade. Read More

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http://dx.doi.org/10.1155/2018/1632902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282152PMC
November 2018
1 Read
3.236 Impact Factor

STING Signaling Promotes Apoptosis, Necrosis, and Cell Death: An Overview and Update.

Mediators Inflamm 2018 25;2018:1202797. Epub 2018 Nov 25.

Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

STING is a newly identified intracellular sensor of foreign and endogenous DNA. STING has been recognized as an activator of immune responses by TBK1/IRF3 and NF-B pathways, and it is suggested to play critical roles in host defense, autoimmune diseases, and tumor immunity. Recent studies have revealed that the outcome of STING activation could vary between distinct cell types and scenarios. Read More

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https://www.hindawi.com/journals/mi/2018/1202797/
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http://dx.doi.org/10.1155/2018/1202797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286756PMC
November 2018
6 Reads