22,846 results match your criteria Mediastinum Germ Cell Tumors


Multiple intercostal neurilemmomas in a Chinese woman.

J Cancer Res Ther 2018 Dec;14(Supplement):S1220-S1222

Department of Respiratory and Critical Care Medicine, Jinling Hospital, Nanjing University Medical School, Nanjing, People's Republic of China.

Neurilemmomas are rare tumors of neural crest cell origin that occur most commonly in the head and neck region. Intercostal neurilemmomas are extremely rare and are mostly seen as solitary tumors in the posterior mediastinum. Only one case report of multiple intercostal neurilemmomas has been documented previously. Read More

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December 2018
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[Georg von Hofmann-Wellenhof-130 years ago the first victim at the beginning of the investigation of infectious diseases in Austria].

Authors:
Heinz Flamm

Wien Med Wochenschr 2018 Dec 11. Epub 2018 Dec 11.

Klinisches Institut, Universität Wien, Martinstraße 7, 3400, Klosterneuburg, Österreich.

After his medical studies in Vienna and Graz, Georg von Hofmann-Wellenhof, born in 1860 in Vienna, became an assistant at the Pathology Institute at the University of Graz. In 1887, he described a bacterium in the pharynx which resembled diphtheria bacillus. As it was not pathogenic in animal experiments, he named it Bacillus pseudodiphthericus, now Corynebacterium pseudodiphthericum. Read More

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December 2018
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Vasoformative Lesions in Mediastinal Mixed Germ Cell Tumors: an Interesting Account of Two Cases Spanning the Benign to Malignant Spectrum.

Indian J Surg Oncol 2018 Dec 18;9(4):624-628. Epub 2018 May 18.

1Department of Histopathology, Sir Ganga Ram Hospital, Rajender Nagar, New Delhi, India.

Extragonadal germ cell tumors are most commonly encountered in the anterior mediastinum. The presence of sarcomatous malignancies in these tumors is a rare phenomenon that adversely impacts patient prognosis because of poor response to conventional cisplatin-based chemotherapy. Even more unusual is the presence of florid benign somatic proliferations that overshadow the germ cell component, often resulting in misdiagnosis and inappropriate management. Read More

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December 2018
1 Read

Transthoracic Needle Biopsy (TNB) under Different Guiding Methods - the Experience of the Thoracic Surgery Clinic of Craiova after the First 235 Cases.

Curr Health Sci J 2015 Jul-Sep;41(3):239-245. Epub 2015 Mar 15.

Radiology and Imaging Department, University of Medicine and Pharmacy of Craiova, Romania.

Transthoracic needle biopsy (TNB) is a fast and safe method used to establish definitive diagnosis for most thoracic lesions, whether the lesion is located in the pleura, the lung parenchyma, or the mediastinum. Diffuse disease and solitary lesions are equally approachable.TNB can avoid (when technically possible) more complex diagnostic interventions such asmediastinoscopy, thoracoscopy and exploratory thoracotomy. Read More

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The usefulness of chemotherapy for control of ventricular arrhythmias secondary to cardiac metastasis of germ cell tumor.

J Cardiol Cases 2010 Dec 8;2(3):e132-e134. Epub 2010 Oct 8.

Department of Pediatrics, Niigata Cancer Center Hospital, Niigata, Japan.

A 14-year-old boy was referred to our hospital because of treatment of germ cell tumor in the anterior mediastinum. Computerized tomographic (CT) scan of the chest and abdomen revealed a large tumor in the anterior mediastinum and multiple metastatic tumors in the lung, liver, kidney, pancreas, and heart. There was a mass in the interventricular septum. Read More

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December 2010

A case of huge lymphatic and venous malformations of the mediastinum.

Respir Med Case Rep 2019 22;26:53-55. Epub 2018 Nov 22.

Department of Respiratory Medicine, Iizuka Hospital, 3-83 Yoshiomachi, Iizuka, Fukuoka 820-0018, Japan.

We herein report a case of huge lymphatic and venous malformations of the mediastinum (LVM). A 19-year-old man presented for evaluation of a mediastinal mass. On chest computed tomography, the mass demonstrated contrast enhancement and showed dilated veins draining into the superior and inferior vena cava, with multiple scattered calcifications. Read More

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November 2018

Tailored Management of Airway Abnormalities in Children with Congenital Single Functional Lung.

J Pediatr Surg 2018 Oct 30. Epub 2018 Oct 30.

Department of Cardiothoracic Surgery, Great Ormond Street Hospital for Children, London, UK. Electronic address:

Objectives: Pediatric patients born with single functional lung can be associated with symptomatic airway abnormalities. Management of such patients is not only technically demanding but is also ethically challenging. This study reports our experience of managing symptomatic airway abnormalities in pediatric patients with congenital single functional lung. Read More

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October 2018

CT-guided Transthoracic Core-Needle Biopsies of Mediastinal and Lung Lesions in 235 Consecutive Patients: Factors Affecting the Risks of Complications and Occurrence of a Final Diagnosis of Malignancy.

Arch Bronconeumol 2018 Dec 4. Epub 2018 Dec 4.

Hospital de Base, Faculdade de Medicina de São José do Rio Preto, São Paulo, Brazil.

Objective: To assess the impact of patient-, lesion- and procedure-related factors on the risks of complications and final diagnosis of malignancy in PCNB of mediastinal and lung lesions.

Material And Methods: We studied a large single-center cohort of 235 consecutive patients (66.8% men; 58. Read More

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December 2018

Robotic Resection of Ectopic Parathyroid Glands in the Superior Posterior Mediastinum.

J Laparoendosc Adv Surg Tech A 2018 Dec 11. Epub 2018 Dec 11.

Division of Thoracic Surgery, Department of Surgery, The Ohio State University Wexner Medical Center , Columbus, Ohio.

Background: Ectopic parathyroid glands can present in a challenging location in the superior posterior mediastinum.

Methods: Two patients with primary hyperparathyroidism were operated on for ectopic paraesophageal parathyroid glands in the superior posterior mediastinum. Sestamibi scan, computed tomography (CT) scan, and photon emission CT were used to identify the exact location of these glands. Read More

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December 2018
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Nonanemic extramedullary hematopoiesis in the posterior mediastinum.

Asian Cardiovasc Thorac Ann 2018 Dec 7:218492318818966. Epub 2018 Dec 7.

Department of Cardiothoracic and Vascular Surgery, Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam.

Extramedullary hematopoiesis is a rare condition characterized by the formation of blood cells outside the bone marrow. It is commonly seen in patients with hematopoietic disorders or chronic anemia. Here, we report the case of a 55-year-old patient who had extramedullary hematopoiesis that manifested as an asymptomatic posterior mediastinal mass. Read More

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December 2018

Functional Polymorphisms in Gene and Neuroblastoma Risk in Chinese Children.

J Cancer 2018 31;9(23):4521-4526. Epub 2018 Oct 31.

Department of Pathology, Anhui Provincial Children's Hospital, Hefei 230051, Anhui, China.

Neuroblastoma is a lethal tumor of the sympathetic nervous system. 8-Hydroxydeoxyguanine (8-OH-dG) formation is a common seen type of oxidative DNA damage, which could be repaired by human oxoguanine glycosylase 1 (hOGG1). To explore the contributing role of gene single nucleotide polymorphisms (SNPs) in neuroblastoma risk, we performed a case-control study by genotyping three SNPs (rs1052133 G>C, rs159153 T>C, rs293795 A>G) in gene. Read More

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October 2018

Successful Treatment of a Late Diagnosed Esophageal Perforation with Mediastinitis and Pericardial Abscess.

J Coll Physicians Surg Pak 2018 Dec;28(12):972-973

Department of Cardiovascular, Gaziosmanpasa University, Tokat, Turkey.

We herein report a case of late diagnosed thoracic esophageal perforation. A 60-year-old man was diagnosed as an esophageal perforation with mediastinitis and pericardial abscess by detailed history taking, chest computed tomography, esophagoscopy and inflammatory findings in his blood test. Surgical drainage of mediastinum and pericardium was able to effectively control infectious process and pericardial fibrosis. Read More

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December 2018
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Esophageal cancer with severe funnel chest treated by simultaneous funnel chest surgery and thoracoscopic esophagectomy: a case report.

BMC Cancer 2018 Dec 4;18(1):1212. Epub 2018 Dec 4.

Department of Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Japan.

Background: Funnel chest is the most common chest deformity, occurring in 0.06-0.3% of the general population. Read More

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December 2018

Mediastinal teratoma presenting with hemoptysis and pleuritis misdiagnosed as tuberculosis (empyema).

BMC Pediatr 2018 Dec 4;18(1):382. Epub 2018 Dec 4.

Department of Respiratory Medicine, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Nanlishi Road 56, Xicheng District, Beijing, People's Republic of China.

Background: Mediastinal teratoma is uncommon in children. It can be very difficult to diagnose especially in early stage. Rarely, teratoma may rupture into adjacent structures and lead to lung lesions or pleuritis. Read More

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December 2018
2 Reads

Localized pancreatic Castleman disease presenting with extrahepatic dilatation of bile ducts: A case report and review of published cases.

Int J Surg Case Rep 2018 Nov 20;54:28-33. Epub 2018 Nov 20.

Universidade Federal do Vale do São Francisco, Av. José de Sá Maniçoba, S/N - Centro, CEP: 56304-917, Petrolina, PE, Brazil. Electronic address:

Introduction: Castleman disease (CD) is a rare polyclonal lymphoproliferative disorder of unknown etiology, which usually develops in the mediastinum. It can also occur in the cervical, retroperitoneal and axillary regions. Localized pancreatic CD is quite rare [1]. Read More

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November 2018
2 Reads

Rapidly growing pleural liposarcoma masquerading as extrapleural hematoma.

Thorac Cancer 2018 Dec 4. Epub 2018 Dec 4.

Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Intrathoracic liposarcoma can occur in the lung, mediastinum, pleura, and chest wall, and tends to remain clinically silent until becoming large enough to displace adjacent structures. Treatment usually includes sufficient surgical resection followed when necessary by adjuvant chemoradiotherapy. We report a case of an uncommon presentation of a rapidly growing pleural liposarcoma, the diagnosis of which may have been obscured by coexisting thoracic trauma with suspected extrapleural hematoma. Read More

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December 2018
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Solitary Lytic Bone Metastasis: A Rare Presentation of Small Lymphocytic Leukemia.

Case Rep Hematol 2018 30;2018:6154709. Epub 2018 Oct 30.

Department of Hematology/Oncology, Joan C. Edwards School of Medicine Marshall University, 1600 Medical Center Dr, Huntington, WV 25701, USA.

Chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) is a hematologic malignancy characterized by an over accumulation of incompetent neoplastic lymphocytes. Bone metastasis in CLL/SLL is very rare. We report a case of a 76-year-old Caucasian female presented with an unresolving pulmonary infiltrate with mediastinal lymphadenopathy concerning for malignancy. Read More

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October 2018
2 Reads

[A man with a painful right shoulder].

Ned Tijdschr Geneeskd 2018 11 27;163. Epub 2018 Nov 27.

Noordwest Ziekenhuisgroep, afd. Chirurgie, locatie Alkmaar.

Posterior sternoclavicular luxations are uncommon and potentially life threatening. When clinically suspected, a computed tomography angiography is the gold standard to investigate whether important structures located in the mediastinum are at risk. A fast reduction should be performed to reduce pain and prevent acute and late complications. Read More

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November 2018
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Programmed Death-ligand 1 (PD-L1) Expression in Thymic Epithelial Tumors.

Appl Immunohistochem Mol Morphol 2018 Nov 28. Epub 2018 Nov 28.

Department of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Thymic epithelial tumors (TETs) are uncommon neoplasms of the mediastinum. The gold standard treatment is complete surgical resection which can be followed by radio/chemotherapy in selected cases. Targeted tyrosine kinase inhibition can be considered in only a limited number of aggressive or metastatic tumors as EGFR, BRAF, or c-kit mutations are rare. Read More

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November 2018
5 Reads

A pilot study of stereotactic body radiation therapy (SBRT) after surgery for stage III non-small cell lung cancer.

BMC Cancer 2018 Nov 29;18(1):1183. Epub 2018 Nov 29.

Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, 665 Elm St, Buffalo, NY, USA.

Background: Standard therapy for stage III non-small cell lung cancer with chemotherapy and conventional radiation has suboptimal outcomes. We hypothesized that a combination of surgery followed by stereotactic body radiation therapy (SBRT) would be a safe alternative.

Methods: Patients with stage IIIA (multistation N2) or IIIB non-small cell lung cancer were enrolled from March 2013 to December 2015. Read More

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November 2018
4 Reads

Dosimetric comparison of anterior posterior-posterior anterior 2-field three-dimensional conformal radiotherapy, 4-field three-dimensional conformal radiotherapy and "forward" plan intensity modulated radiotherapy techniques in female lymphoma patients irradiated to neck and mediastinum.

J Cancer Res Ther 2018 Oct-Dec;14(6):1389-1396

Department of Radiation Oncology, Dokuz Eylül University Medical Faculty, Izmir, Turkey.

Aim: Dosimetric comparison of three different techniques in female lymphoma patients who had radiotherapy (RT) to the neck and mediastinum.

Setting And Design: Retrospective clinical study.

Materials And Methods: Computerized tomography-simulator images of eight patients were obtained retrospectively. Read More

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November 2018

Successful Use of Pembrolizumab to Treat Refractory Thymic Carcinoma with High PD-L1 Expression.

Case Rep Oncol 2018 Sep-Dec;11(3):688-692. Epub 2018 Oct 31.

Department of Respiratory Medicine, Toho University Graduate School of Medicine, Tokyo, Japan.

Thymic carcinoma is a relatively rare and aggressive thymic epithelial tumor. Herein, we report successful treatment of thymic carcinoma with pembrolizumab. A 68-year-old woman was admitted to our hospital for evaluation of chest pain. Read More

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October 2018
2 Reads

Application of endoscopic ultrasound-guided-fine needle aspiration combined with cyst fluid analysis for the diagnosis of mediastinal cystic lesions.

Thorac Cancer 2018 Nov 27. Epub 2018 Nov 27.

Department of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China.

Background: Mediastinal cystic lesions account for approximately 15-20% of all mediastinal masses and are difficult to differentiate because of similar imaging manifestation. The aim of this study was to differentiate mediastinum cystic lesions through endoscopic ultrasound-guided-fine needle aspiration (EUS-FNA) and parameters from cyst-fluid analysis.

Methods: Over a period of eight years, 37 patients suspected with mediastinal cystic lesions were assessed. Read More

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November 2018
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Distant Thromboembolic Disease Diagnosed by Endoscopic Ultrasound in Pancreatic Cancer: A Case Series.

GE Port J Gastroenterol 2018 Nov 6;25(6):317-321. Epub 2018 Mar 6.

Gastroenterology Department, Hospital da Luz, Lisbon, Portugal.

Thrombosis and cancer have a very well-known association. Pancreatic cancer has the highest risk for thrombotic events amongst gastrointestinal cancers and is a leading direct cause of death in cancer patients. We assessed the role of endoscopic ultrasound (EUS) in identifying distant thrombotic events in pancreatic cancer patients. Read More

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November 2018
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An Unusual Mass of Posterior Mediastinum: A Case of Retrotracheal Parathyroid Adenoma Presenting With Primary Hyperparathyroidism.

Clin Med Insights Circ Respir Pulm Med 2018 16;12:1179548418811840. Epub 2018 Nov 16.

Department of Thoracic Surgery, CHU Hassan II, Fès, Morocco.

Although parathyroid ectopy in the mediastinum has been the subject of several publications, its location in the posterior mediastinum is very rarely reported. We report a case of a 69-year-old patient who presented with clinical symptoms of malignant hypercalcemia due to a retrotracheal mediastinal parathyroid adenoma. The surgical excision leads to a quick normalisation of the phosphocalcic balance with improvement of the clinical symptoms. Read More

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November 2018
3 Reads

Cytomorphology of ciliated foregut cyst of the pancreas.

Diagn Cytopathol 2018 Nov 26. Epub 2018 Nov 26.

Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Ciliated foregut cysts are benign congenital lesions that are commonly found in the mediastinum but are rare in the retroperitoneum. So far only very few cases of ciliated foregut cyst found in the pancreas have been reported, and less with cytologic findings described. We report a case of ciliated foregut cyst in pancreas in an asymptomatic patient diagnosed on fine needle aspiration cytology. Read More

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November 2018

Mediastinal seminoma presenting as a neck mass falsely diagnosed as anaplastic thyroid carcinoma: A case report.

Diagn Cytopathol 2018 Nov 23. Epub 2018 Nov 23.

Department of Lab Medicine and Pathology - Histopathology Section, Hamad Medical Corporation, Doha, State of Qatar.

Germ cell tumors can occur in the mediastinum. They account for about 20% of tumors at this location. The majority are located in the anterior mediastinum and usually occur in young adult males. Read More

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November 2018
6 Reads

Thymic inflammatory pseudotumor with multilocular thymic cyst caused by immunoglobulin G4-related disease.

Thorac Cancer 2018 Nov 23. Epub 2018 Nov 23.

Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

A 44-year-old man was referred to our hospital after an anterior mediastinal tumor was noted on computed tomography during follow-up observation after left testicular seminoma resection. Chest computed tomography revealed an enhanced mass measuring 33 x 16 x 15 mm at the anterior mediastinum. Chest magnetic resonance imaging revealed high signal intensity on T2-weighted imaging, and F  fluorodeoxyglucose-positron emission tomography showed a maximum standardized uptake of 12. Read More

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November 2018
5 Reads

Assessment of therapeutic effects of statin on cardiac sympathetic nerve activity and cardiac events in patients with ischemic cardiomyopathy and mild to moderate heart failure.

Nucl Med Commun 2018 Nov 19. Epub 2018 Nov 19.

Institute for Clinical and Translational Science, Nara Medical University Hospital, Kashihara, Nara.

Introduction: We determined whether statin therapy improved cardiac sympathetic nerve activity as evaluated using iodine-123-metaiodobenzylguanidine (I-MIBG) scintigraphy, and whether this therapy affects prognosis in patients with ischemic cardiomyopathy.

Patients And Methods: This study was a subanalysis of our previous report of the result that the serial I-MIBG scintigraphic studies were the most useful prognostic indicator in patients with heart failure. Patients with heart failure [left ventricular ejection fraction (LVEF) <45%] but no cardiac events for at least 5 months before the study were identified according to their history of decompensated acute heart failure requiring hospitalization. Read More

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November 2018
3 Reads

Metastatic thymic carcinoid responds to chemoradiation and octreotide: A case report.

Medicine (Baltimore) 2018 Nov;97(47):e13286

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Rationale: Thymic carcinoids are a rare type of malignant neuroendocrine tumors which have a poor prognosis due to their distant metastasis, invasive behaviour, and postoperative recurrence. Surgical resection is still the fundamental mode for treating thymic carcinoids. Here, we report the rapid shrinkage of an atypical thymic carcinoid with multiple metastases following chemoradiation plus octreotide as a first-line therapy PATIENT CONCERNS:: A 39-year-old Chinese man presented with chest tightness, dyspnea with a history of lumbago and untreated malignant thymoma. Read More

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November 2018
5 Reads

High-risk group of upper and middle mediastinal lymph node metastasis in patients with esophagogastric junction carcinoma.

Ann Gastroenterol Surg 2018 Nov 13;2(6):419-427. Epub 2018 Oct 13.

Department of Surgery Keio University School of Medicine Tokyo Japan.

Aim: The aim of the present study was to clarify esophagogastric junction (EGJ) carcinoma patients who are at high risk of upper and middle mediastinal lymph node (MLN) metastasis.

Methods: This was a retrospective study and included 110 consecutive patients with EGJ carcinoma who underwent R0/R1 resection at Keio University Hospital between January 2000 and December 2013.

Results: Of the 110 patients, 18 (16. Read More

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November 2018

Intra-thymic bronchogenic cyst an extremely rare tumor of anterior mediastinum in adults.

J Cardiothorac Surg 2018 Nov 20;13(1):120. Epub 2018 Nov 20.

Department of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Background: Intra-thymic bronchogenic cysts are a rare entity but should be considered in the differential of all non-invasive thymic masses.

Case Presentation: We describe a 50-year-old patient who was found to have an incidental thymic mass on computer tomography of the chest. Non-invasive thymoma was suspected and a thoracoscopic thymectomy was performed. Read More

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November 2018
2 Reads
1.018 Impact Factor

[Left-sided Chylothorax and Tumor of the Right Anterior Mediastinum].

Pneumologie 2018 Dec 19;72(12):851-854. Epub 2018 Nov 19.

Thoraxchirurgische Abteilung des LungenZentrums Saar, SHG-Kliniken, Völklingen.

An 82-year-old male patient presented with a left-sided spontaneous chylothorax. A computed tomographic scan of the chest revealed a cystic tumor in the right upper anterior mediastinum and nodules in the left mediastinum that we interpreted as enlarged lymph nodes. On suspicion of lymphoma and for therapy of chylothorax, we performed a left-sided thoracotomy. Read More

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December 2018
3 Reads

SMARCA4-deficient Thoracic Sarcomas: Clinicopathologic Study of 30 Cases With an Emphasis on Their Nosology and Differential Diagnoses.

Am J Surg Pathol 2018 Nov 16. Epub 2018 Nov 16.

Bergonie Institute, Department of Pathology, Bordeaux, France.

SMARCA4-deficient thoracic sarcoma (SMARCA4-DTS) is a recently described entity with an aggressive clinical course and specific genetic alterations of the BAF chromatin remodeling complex. In the present study, we reviewed the clinical and pathologic features of 30 cases of SMARCA4-DTS, discussed its main differential diagnoses and the challenging diagnostic scenarios that the average pathologist may face. In addition, we tested the specificity of the "SMARCA4-DTS immunohistochemical signature" (co-loss of SMARCA4 and SMARCA2 with overexpression of SOX2) in a large cohort of intrathoracic malignancies. Read More

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November 2018
4 Reads

Mediastinal mature teratoma perforating the right lung that was successfully resected with complete thoracoscopic surgery: A case report.

Int J Surg Case Rep 2018 Nov 2;53:299-302. Epub 2018 Nov 2.

Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi, Japan.

Introduction: A perforating mediastinal mature teratoma can cause severe inflammation and adhesion; therefore, open surgery is usually performed. Asymptomatic perforation involving a teratoma is very rare. Complete thoracoscopic surgery is often difficult because of inflammation associated with perforation and the frequently large size of a mediastinal mature teratoma. Read More

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November 2018
4 Reads

Pulmonary Arterial Bypass Surgery for Fibrosing Mediastinitis Causing Severe Pulmonary Hypertension.

Ann Thorac Surg 2018 Nov 14. Epub 2018 Nov 14.

Istanbul University, Istanbul Medical Faculty, Department of Thoracic Surgery.

In this case report, we present a patient with mediastinal fibrosis. The mass lesion was expanding from the mediastinum to the cervical region and surrounding the major vascular structures. The patient has symptomatic dyspnea at rest and pulmonary hypertension due to stenosis of the bilateral main pulmonary arteries (PA). Read More

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November 2018
1 Read

Long-term prognosis of low-risk neuroblastoma treated by surgery alone: an experience from a single institution of China.

World J Pediatr 2018 Nov 16. Epub 2018 Nov 16.

Department of Pediatric Surgery, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.

Background: Low-risk neuroblastomas have favorable biologic characteristics. Children Oncology Group (COG) proposed that surgical resection of the primary tumor was sufficient. We evaluated the long-term prognosis of surgery alone for patients with low-risk neuroblastoma in China. Read More

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November 2018
1 Read

Frozen section of lung, pleura and mediastinum specimen: Retrospective analysis of 5-years practical experiences and review of the literature.

Cesk Patol 2018 ;54(3):127-131

Thoracic frozen section biopsies including lungs, pleura and mediastinum have crucial role in differential diagnosis of solitary lesions of the lungs and mediastinum. There is a significant difference in patient´s therapeutical management, if the patients suffer from lung primary malignant tumour, metastasis or non-malignant lesion. In this review, we summarize the usefulness of frozen section biopsies in thoracic surgery and provide 5-years of experiences with thoracic frozen section biopsies performed at the Department of Pathology and Molecular Medicine of Thomayer Hospital in Prague. Read More

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January 2018
2 Reads

Rare presentation of giant isolated enteric cyst in anterior mediastinum.

Ann Thorac Surg 2018 Nov 13. Epub 2018 Nov 13.

Division of Thoracic Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Chung University, Tainan, Taiwan. Electronic address:

Mediastinal enteric cysts are extremely rare. In the published English literature, the majority of such cysts are reported in the right posterior mediastinal position; often with vertebral anomalies. Just 4 cases have been reported for enteric cysts in atypical mediastinal locations since 1997. Read More

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November 2018
2 Reads

A Fatal Mediastinitis Due to a Neck Trauma from an Undeclared Assault.

J Forensic Sci 2018 Nov 16. Epub 2018 Nov 16.

Istituto di Sanità Pubblica, sezione di Medicina Legale, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168, Roma, Italy.

History of neck trauma should be promptly investigated in patients with severe infections of the chest as mediastinitis. We present a forensic case of a death due to a mediastinitis in a patient with an undetected fracture of the superior horn of the thyroid cartilage that was exclusively revealed at autopsy examination. Histological analyses of the neck tissues showed signs of pharyngeal mucosal microperforation caused by the fracture and surrounded by an inflammatory reaction. Read More

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November 2018
2 Reads

Angiographic embolization followed by piecemeal resection of giant posterior mediastinal schwannoma: Case report and concise review.

Int J Surg Case Rep 2018 Oct 29;53:250-253. Epub 2018 Oct 29.

Department of Surgery, University of Florida, Gainesville, FL, United States. Electronic address:

Introduction: Posterior mediastinal masses present unique diagnostic and therapeutic challenges, particularly when large highly vascularized tumors extend toward or emanate from the spinal cord. The rare nature of these tumors precludes the development of standardized management algorithms, underscoring the importance of case reports.

Presentation Of Case: A 57 year old female presented with exertional dyspnea and right chest pressure. Read More

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October 2018

Feasibility of a single mediastinal drain through the abdominal wall after esophagectomy.

Medicine (Baltimore) 2018 Nov;97(46):e13234

Department of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan.

This study evaluated the safety and effectiveness of a single mediastinal drainage tube in the thoracic and abdominal cavity after minimally invasive esophagectomy (MIE). This study was undertaken to determine if the procedure could be included in a fast-track surgery program for resectable esophageal carcinoma (EC).From June 17 to November 30, 2015, clinical data for 78 eligible patients who had undergone a fast-track surgery program and MIE were retrospectively analyzed. Read More

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November 2018
4 Reads

Pneumomediastinum and pneumopericardium as rare complications after retroperitoneal transpsoas lateral lumbar interbody fusion surgery: A case report.

Medicine (Baltimore) 2018 Nov;97(46):e13222

Department of Orthopaedic Surgery, Soonchunhyang University Hospital, Yongsan-gu, Seoul, Republic of Korea.

Rationale: Pneumomediastinum and pneumopericardium refer to conditions in which air exists within the mediastinum and pericardium, respectively. There is the communication between the mediastinum, pericardium, and retroperitoneum. We present the first report of rare complications (pneumomediastinum and pneumopericardium) after retroperitoneal transpsoas lateral lumbar interbody fusion (LLIF) surgery. Read More

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November 2018
5 Reads

Pediatric Bronchogenic Cysts: A Case Series of Six Patients Highlighting Diagnosis and Management.

J Invest Surg 2018 Nov 15:1-6. Epub 2018 Nov 15.

a Department of Otolaryngology-Head and Neck Surgery , Philadelphia College of Osteopathic Medicine , Philadelphia , PA , USA.

Purpose: To present six cases of bronchogenic cysts while highlighting the diagnosis and management of this anomaly.

Materials And Methods: A retrospective chart review was conducted using our institution's Pathology database. The database was queried for "bronchogenic cyst. Read More

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November 2018
4 Reads

Pre-existing pulmonary fibrosis is a risk factor for anti-PD-1-related pneumonitis in patients with non-small cell lung cancer: A retrospective analysis.

Lung Cancer 2018 Nov 3;125:212-217. Epub 2018 Oct 3.

Department of Thoracic Oncology, Aichi Cancer Center Hospital, 1-1, Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, Japan. Electronic address:

Objectives: Pneumonitis related to the use of anti-programmed death 1 (PD-1) antibodies is a common immune-related adverse event that can be life-threatening. However, the relationship between pulmonary fibrosis/emphysema and the incidence of anti-PD-1-related pneumonitis is unclear.

Materials And Methods: We retrospectively reviewed data from 123 patients who were diagnosed with non-small-cell lung cancer and treated with anti-PD-1 antibodies (nivolumab or pembrolizumab) at the Aichi Cancer Center Hospital, Japan, between December 17, 2015, and November 30, 2017. Read More

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November 2018
12 Reads

Lymphangioma of the heart as a rare tumor: A case report.

Int J Surg Case Rep 2018 Oct 8;53:246-249. Epub 2018 Oct 8.

Cardiothoracic Surgery Department, Santa Maria Hospital, Lisbon, Portugal.

Introduction: Tumors of the heart are uncommon, and lymphangiomas are among the rarest of this group, with very few cases reported. These tumors consist of a benign slow-flow vascular malformation.

Presentation Of Case: We report a case of a man diagnosed incidentally with a pericardial mass and our surgical approach for its treatment. Read More

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October 2018
1 Read

Caudal Mediastinal Fish Hook Foreign Body with Pulmonary Artery Penetration in Two Dogs.

J Am Anim Hosp Assoc 2018 Nov 14. Epub 2018 Nov 14.

From the Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.

A 1.5 yr old spayed female mixed-breed dog and a 3 yr old spayed female Labrador retriever were evaluated for suspected esophageal fishhook foreign bodies. Radiographs yielded fishhook foreign bodies present caudal to the cardiac silhouette. Read More

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November 2018
3 Reads

Descending necrotizing mediastinitis in a healthy young adult.

Ther Clin Risk Manag 2018 17;14:2013-2017. Epub 2018 Oct 17.

Department of General Internal Medicine 4, Kawasaki Medical School, Okayama, Japan,

A 26-year-old man with right lower mandibular and chest pain, fever, and respiratory distress was urgently transported to our hospital. CT images revealed gas collection and an abscess from the neck to the mediastinum with bilateral pleural effusion. Descending necrotizing mediastinitis (DNM) induced by an odontogenic infection of a right mandibular molar abscess was diagnosed. Read More

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October 2018
4 Reads