2,225 results match your criteria Mediastinum Germ Cell Tumors


[A CASE WITH LATE RECURRENCE OF EXTRAGONADAL GERM CELL TUMOR].

Nihon Hinyokika Gakkai Zasshi 2018 ;109(1):40-44

Department of Urology, Nagoya University Graduate School of Medicine.

A 61-year-old man had undergone resection of teratoma with a histological component of seminoma occurring in the anterior mediastinum at 26 years of age in 1978, followed by radiation treatment to the resected area. He had a recurrence tumor in the left retroperitoneum 2 years later, which was resected combined with left nephrectomy and was proved to be the same pathology as the initial tumor. At 36 years after the initial treatment, the tumor recurred in the right lung. Read More

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http://dx.doi.org/10.5980/jpnjurol.109.40DOI Listing
February 2019
1 Read

Growing teratoma syndrome in primary mediastinal germ cell tumor: our experience.

Asian Cardiovasc Thorac Ann 2019 Feb 15;27(2):98-104. Epub 2019 Jan 15.

5 Department of Cardiovascular and Thoracic Surgery, Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry, India.

Background: Growing teratoma syndrome is a rare phenomenon seen in nonseminomatous germ cell tumors after chemotherapy, where the tumor grows paradoxically despite normalization of tumor markers. It has been found in various locations, most commonly, the retroperitoneum in association with metastatic disease. The occurrence of growing teratoma syndrome in a mediastinal primary is very rare and there are only a few reports in the literature. Read More

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http://dx.doi.org/10.1177/0218492318823345DOI Listing
February 2019
4 Reads

Surgical removal of adult recurrent neuroblastoma located in the posterior mediastinum and retroperitoneum: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13642

Department of Hepatobiliary Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China.

Rationale: Adult recurrent neuroblastoma is extremely rare, especially in the posterior mediastinum and retroperitoneal cavity. The surgical treatment of this special part of the tumor is also a clinical difficulty.

Patient Concerns: This study reports a case of a 24-year-old man with a history of treated posterior mediastinal neuroblastoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000013642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320002PMC
December 2018

Vasoformative Lesions in Mediastinal Mixed Germ Cell Tumors: an Interesting Account of Two Cases Spanning the Benign to Malignant Spectrum.

Indian J Surg Oncol 2018 Dec 18;9(4):624-628. Epub 2018 May 18.

1Department of Histopathology, Sir Ganga Ram Hospital, Rajender Nagar, New Delhi, India.

Extragonadal germ cell tumors are most commonly encountered in the anterior mediastinum. The presence of sarcomatous malignancies in these tumors is a rare phenomenon that adversely impacts patient prognosis because of poor response to conventional cisplatin-based chemotherapy. Even more unusual is the presence of florid benign somatic proliferations that overshadow the germ cell component, often resulting in misdiagnosis and inappropriate management. Read More

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http://link.springer.com/10.1007/s13193-018-0778-y
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http://dx.doi.org/10.1007/s13193-018-0778-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265192PMC
December 2018
12 Reads

Mediastinal seminoma presenting as a neck mass falsely diagnosed as anaplastic thyroid carcinoma: A case report.

Diagn Cytopathol 2018 Nov 23. Epub 2018 Nov 23.

Department of Lab Medicine and Pathology - Histopathology Section, Hamad Medical Corporation, Doha, State of Qatar.

Germ cell tumors can occur in the mediastinum. They account for about 20% of tumors at this location. The majority are located in the anterior mediastinum and usually occur in young adult males. Read More

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http://dx.doi.org/10.1002/dc.24090DOI Listing
November 2018
12 Reads

Metastatic thymic carcinoid responds to chemoradiation and octreotide: A case report.

Medicine (Baltimore) 2018 Nov;97(47):e13286

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Rationale: Thymic carcinoids are a rare type of malignant neuroendocrine tumors which have a poor prognosis due to their distant metastasis, invasive behaviour, and postoperative recurrence. Surgical resection is still the fundamental mode for treating thymic carcinoids. Here, we report the rapid shrinkage of an atypical thymic carcinoid with multiple metastases following chemoradiation plus octreotide as a first-line therapy PATIENT CONCERNS:: A 39-year-old Chinese man presented with chest tightness, dyspnea with a history of lumbago and untreated malignant thymoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000013286DOI Listing
November 2018
11 Reads

Perioperative management of an anterior mediastinal teratoma in an infant: one more tool in the toolbox.

BMJ Case Rep 2018 Nov 1;2018. Epub 2018 Nov 1.

Surgery, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, USA.

Anterior mediastinal masses present a significant challenge in the perioperative period. Standard anaesthetic induction and airway management are often not feasible due to the risk of complete respiratory and/or cardiovascular collapse. Invasive manoeuvres, such as extracorporeal membrane oxygenation, cardiac bypass, or tracheal or bronchial stenting, are sometimes not applicable due to significant anatomic aberration. Read More

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http://dx.doi.org/10.1136/bcr-2018-227022DOI Listing
November 2018
8 Reads

Renin-producing germ cell tumor in the pineal apparatus and mediastinum: A rare case report.

J Cancer Res Ther 2018 Sep;14(Supplement):S806-S808

Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.

Ectopic extrarenal renin-producing tumor is a rare disease with approximately 30 case reports in English literature. We herein present the first case of renin-producing germ cell tumors in the pineal apparatus and mediastinum. A 26-year-old man who had undergone craniotomy for the treatment of pineal tumor was found to have hypertension at a regular visit postoperatively. Read More

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http://dx.doi.org/10.4103/0973-1482.180682DOI Listing
September 2018
2 Reads

Positron emission tomography/computed tomography as a clinical diagnostic tool for anterior mediastinal tumors.

Surg Today 2019 Feb 10;49(2):143-149. Epub 2018 Sep 10.

Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan.

Purpose: The purpose of this study was to assess the usefulness of positron emission tomography/computed tomography (PET/CT) in the differential diagnosis of anterior mediastinal tumors.

Methods: A total of 94 patients with anterior mediastinal masses or nodules (male, n = 41; female, n = 53; age, 17-84 years) were retrospectively evaluated. All patients were evaluated by PET/CT and the masses or nodules were histologically diagnosed in our institution. Read More

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http://dx.doi.org/10.1007/s00595-018-1712-1DOI Listing
February 2019
5 Reads

Thoracoscopic resection of a cystic seminoma of the mediastinum.

Asian J Endosc Surg 2018 Sep 5. Epub 2018 Sep 5.

Department of Pathology, Suwa Red Cross Hospital, Suwa, Japan.

Mediastinal seminoma is an uncommon tumor that accounts for 25% of primary mediastinal germ cell tumors, which in turn comprise fewer than 5% of all germ cell tumors. Although CT normally shows a solid, lobulated tumor, mediastinal cystic seminoma has rarely been described. Here, we report a 24-year-old man who presented with a mediastinal cystic tumor that was resected after an 18-month delay via video-assisted thoracoscopic surgery while in the supine position; the procedure involved lifting the chest wall with a subcutaneous Kirschner wire. Read More

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http://doi.wiley.com/10.1111/ases.12647
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http://dx.doi.org/10.1111/ases.12647DOI Listing
September 2018
5 Reads

[Beta-hCG-producing thymic teratoma: an uncommon cause of peripheral precocious puberty].

Rev Chil Pediatr 2018 Jun;89(3):373-379

Servicio de Pediatría, Hospital Dr. Hernán Henríquez Aravena, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile.

Introduction: Among the causes of peripheral precocious puberty in men are the beta-human cho rionic gonadotropin (Β-HCG)-secreting tumors, such as hepatoblastomas, dysgerminomas, chorio carcinomas, and immature teratomas. In pediatrics, the mediastinal teratomas are rare, representing the 7-10% of extragonadal teratomas.

Objective: To describe the case of a patient with peripheral precocious puberty due to a Β-HCG -secreting thymic teratoma. Read More

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http://dx.doi.org/10.4067/S0370-41062018005000304DOI Listing
June 2018
14 Reads

Pediatric paraganglioma of the posterior mediastinum: A case report and review of literature.

Medicine (Baltimore) 2018 Jul;97(27):e11212

Department of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.

Rationale: Paraganglioma is rare in children and most pheochromocytomas originate in the adrenal gland.

Patient Concerns: The clinical characteristics, diagnosis, and managements in a 9-year-old boy who presented with vomiting and occasional headache with a blood pressure of 210/170 mm Hg was retrospectively reviewed. CT scan of the chest revealed a 7 × 5-cm-sized soft tissue mass in the left paraspinal area. Read More

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http://dx.doi.org/10.1097/MD.0000000000011212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076022PMC
July 2018
2 Reads

Intradural Ganglioneuroma Mimicking Lumbar Disc Herniation: Case Report.

World Neurosurg 2018 Sep 7;117:40-45. Epub 2018 Jun 7.

Department of Neurosurgery, Rio Hortega University Hospital, Valladolid, Castilla y León, Spain.

Background: Ganglioneuroma (GN) is a slow-growing tumor originating from the neural crest-derived cells, which form the sympathetic nervous system. These tumors can affect anywhere along the peripheral autonomic ganglion sites and are most commonly found in the mediastinum and retroperitoneum. Spinal GNs are extremely rare and, so far, only 1 case arising from a lumbar nerve root has been reported in the English literature. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.05.225DOI Listing
September 2018
4 Reads

Primary neuroendocrine carcinoma of the thymus: A retrospective analysis from a regional cancer center in Western India.

Indian J Cancer 2017 Jul-Sep;54(3):556-559

Department of Medical and Paediatric Oncology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India.

Primary neuroendocrine tumors of the thymus are unusual anterior mediastinal tumors with a variable prognosis. A retrospective analysis of five patients with primary neuroendocrine tumors of the thymus admitted to the Gujarat Cancer and Research Institute, Ahmedabad, between 2012 and 2016, was done to study the clinical profile and outcome of these patients. The role of various prognostic factors such as surgical resection, histological grade, and Masaoka-Koga staging was also analyzed. Read More

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http://dx.doi.org/10.4103/ijc.IJC_295_17DOI Listing
September 2018
2 Reads

Immature teratoma mimicking pulmonary stenosis: a case report.

J Med Case Rep 2018 May 9;12(1):125. Epub 2018 May 9.

Medical Faculty, University of Prishtina, Prishtina, Republic of Kosovo.

Background: Immature teratoma in a mediastinal location is a rare disease that might present as a valve pathology. Germ cell tumors with mediastinal locations account for up to 6% of immature teratoma cases. We present a case of an immature teratoma located primarily in the anterior mediastinum that manifested solely through symptoms of pulmonary stenosis. Read More

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http://dx.doi.org/10.1186/s13256-018-1651-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941325PMC
May 2018
6 Reads

Mediastinal yolk sac tumor infiltrating the heart.

Exp Oncol 2018 Mar;40(1):82-84

Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta 13230, Indonesia.

Background: As a rare tumor, yolk sac tumor is a type of neoplasm that appears like the yolk sac, extraembryonic mesenchyme, and allantois. The mediastinum is the second most frequent area after the gonadal area.

Case Report: We present an extremely rare case of 15 years old boy with mediastinal yolk sac tumor. Read More

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March 2018
22 Reads

Primary cervical ganglioneuroblastoma: A case report.

Medicine (Baltimore) 2018 Mar;97(12):e0090

Department of Otorhinolaryngology, Head & Neck Surgery, West China Hospital.

Rationale: Ganglioneuroblastoma is usually located in the adrenal gland, retroperitoneal ganglia, or posterior mediastinum, but rarely occurs in the parapharyngeal space.

Patient Concerns: A 4-year-old girl presented with complaint of progressive inspiratory dyspnea and dysphagia, accompanying left-side Horner's syndrome.

Diagnose: Computed tomography (CT) scan revealed a giant mass with irregular low density in left oropharyngeal and posterior pharyngeal wall. Read More

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http://dx.doi.org/10.1097/MD.0000000000010090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895351PMC
March 2018
7 Reads

Minimally invasive, ionizing-free, and ultrasound-guided technique to biopsy anterior mediastinal masses: first 60 cases.

Panminerva Med 2018 09 15;60(3):132-133. Epub 2018 Mar 15.

Unit of Internal Medicine, Department of Medicine, Città della Salute e della Scienza, Turin, Italy.

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http://dx.doi.org/10.23736/S0031-0808.18.03390-6DOI Listing
September 2018
15 Reads

Cough, Hemoptysis and Hair Expectoration: An Intrapulmonary Teratoma.

J Coll Physicians Surg Pak 2018 03;28(3):243-244

Department of Pathology & Laboratory Medicine, The Aga Khan University and Hospital, Karachi.

Teratomas can be found in different organs of the body and may involve gonads, saccrococcygeal region, mediastinum and other sites. Intrathoracic teratomas always occur in mediastinum and less often arise within the lung. As teratomas mostly involve sex organs (gonads), they rarely occur as extra-gonadal tumors accounting for only 3% of all the cases and very small percentage of such tumors occur in mediastinum. Read More

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http://dx.doi.org/10.29271/jcpsp.2018.03.243DOI Listing
March 2018
8 Reads

Middle mediastinal schwannoma concealed by asthma and GORD.

BMJ Case Rep 2018 Mar 13;2018. Epub 2018 Mar 13.

Department of Surgery, University of Santo Tomas Hospital, Manila, Philippines.

Neurogenic tumours of the mediastinum in adults occur most often at the posterior mediastinum, majority of which are benign of nerve sheath in origin. A 72-year-old woman, known asthmatic, presented with chronic symptoms of hoarseness, dysphagia, chest heaviness, easy fatigability, cough, epigastric pain, feeling of abdominal fullness and choking with food intake and at a supine position. Treated for other disorders, routine chest X-ray incidentally found a homogenous convex radiodensity at the right paratracheal area; mass which was also observed with CT and 18F-fludeoxyglucose-positron emission tomography/CT scan studies. Read More

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http://dx.doi.org/10.1136/bcr-2017-223795DOI Listing
March 2018
5 Reads

Extragonadal germ cell tumor of the posterior mediastinum in a child complicated with spinal cord compression: a case report.

BMC Pediatr 2018 03 5;18(1):97. Epub 2018 Mar 5.

Department of Pediatrics, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Germ cell tumors (GCTs) in children are rare neoplasms with diverse pathological findings according to the site and age of presentation. The most common symptoms in children with mediastinal GCTs, which are nonspecific, are dyspnea, chest pain, cough, hemoptysis, vena cava occlusion syndrome, and fatigue/weakness. Because of these nonspecific symptoms, it is difficult to suspect a mediastinal mass. Read More

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http://dx.doi.org/10.1186/s12887-018-1070-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838956PMC
March 2018
18 Reads

Superior mediastinal typical carcinoid detected by 99mTc-MIBI SPECT/CT imaging: A case report.

Medicine (Baltimore) 2017 Dec;96(52):e9457

Rationale: This is a rare case of mediastinal typical carcinoid tumor with elevated parathyroid hormone (PTH) and hypercalcemia detected by Tc -methoxy-isobutyl-isonitrile(Tc-MIBI) single photon emission computed tomography/computed tomography (SPECT/CT) imaging.

Patient Concerns: A 65-year-old male patient presented with hypercalcemia and elevated PTH.

Diagnoses: The preoperative diagnosis was ectopic parathyroid adenoma in the right superior mediastinum. Read More

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http://dx.doi.org/10.1097/MD.0000000000009457DOI Listing
December 2017
5 Reads

Primary mediastinal yolk sac tumor treated with platinum-based chemotherapy and extended resection: Report of seven cases.

Thorac Cancer 2018 04 10;9(4):491-494. Epub 2018 Jan 10.

Department of Thoracic Surgery, Peking University First Hospital, Peking University, Peking, China.

Background: Primary mediastinal yolk sac tumor, which is also known as endodermal sinus tumor, is a rare but lethal neoplasm, and it is a kind of mediastinal non-seminomatous germ cell tumor. The current standard treatment in mediastinal non-seminomatous germ cell tumors is chemotherapy combined with postchemotherapy residual mass resection. We report on seven cases of primary mediastinal yolk sac tumor treated with platinum-based chemotherapy and extended resection. Read More

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http://dx.doi.org/10.1111/1759-7714.12591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879052PMC
April 2018
22 Reads
1.130 Impact Factor

Pathological diagnosis of pulmonary large cell neuroendocrine carcinoma by endobronchial ultrasound-guided transbronchial needle aspiration.

Thorac Cancer 2018 02 22;9(2):273-277. Epub 2017 Dec 22.

Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.

Background: Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a relatively rare subtype of lung malignancy. According to revised 2015 World Health Organization (WHO) criteria for the pathological diagnosis of LCNEC, neuroendocrine markers must be examined by immunohistochemistry. In this study, we reevaluated endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) samples of patients previously diagnosed with LCNEC using the revised WHO criteria. Read More

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http://dx.doi.org/10.1111/1759-7714.12576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792718PMC
February 2018
3 Reads

Imaging of Intrathoracic Paragangliomas.

Semin Ultrasound CT MR 2017 Dec 4;38(6):584-593. Epub 2017 Aug 4.

Department of Diagnostic Radiology, The University of Texas Health Science Center at San Antonio, San Antonio, TX.

Intrathoracic paragangliomas are uncommon and only represent 1%-2% of paragangliomas. They are most commonly found in mediastinal compartments (aortopulmonary window or posterior mediastinum). Computed tomography, magnetic resonance, and specific nuclear medicine radiotracers are routinely used to characterize these lesions and help exclude other more common conditions. Read More

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http://dx.doi.org/10.1053/j.sult.2017.07.004DOI Listing
December 2017
5 Reads

Pitfalls of Frozen Section Diagnosis for Paraganglioma: A Clinicopathologic Analysis and Review of the Literature.

Int J Surg Pathol 2018 May 23;26(3):213-220. Epub 2017 Nov 23.

3 Department of Pathololgy, Sungkyunkwan University, Seoul, Republic of Korea.

Few paraganglioma (PG) cases include frozen section diagnoses, and therefore, the accuracy of frozen section diagnosis for PG remains unknown. To better understand the histologic characteristics and pitfalls of frozen section findings for PG, 15 PG cases with frozen section diagnoses were selected from 12 articles through PubMed (1984-2015). In addition, we included 3 cases of PG for which intraoperative consultations were requested during a 5-year period (2012-2016) in 2 hospitals. Read More

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http://dx.doi.org/10.1177/1066896917742199DOI Listing
May 2018
34 Reads

Ganglioneuroma of the Neck: A case report.

Ethiop Med J 2017 Jan;55(1):69-71

Ganglioneuroma (GN) is benign tumor arising from sympathetic ganglion which commonly occurs at posterior mediastinum, retroperitoneum and adrenal gland. Rarely, it may also present in cervical region as slow growing painless neck mass. Here we present a 7 years old female child with 4 years duration of slow growing left lateral neck mass. Read More

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January 2017
3 Reads

Radiological-pathological correlation of malignant teratoma with liposarcomatous transformation: Proven by repeated transthoracic needle biopsy.

Thorac Cancer 2018 01 6;9(1):185-188. Epub 2017 Nov 6.

Department of Pathology, Chonnam National University Medical School, Gwangju, South Korea.

A mediastinal germ cell tumor with a sarcomatous component is extremely rare and is accompanied by a poor prognosis. Clinical and radiologic diagnosis is very difficult. Herein, we report a rare case of anterior mediastinal malignant teratoma containing a growing liposarcomatous component and detail the diagnostic process. Read More

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http://dx.doi.org/10.1111/1759-7714.12553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754310PMC
January 2018
14 Reads

[Mediastinal Hemangioma Mimicking a Mature Cystic Teratoma;Report of a Case].

Kyobu Geka 2017 Nov;70(12):1033-1036

Department of General Thoracic Surgery, Sakaide City Hospital, Sakaide, Japan.

A 16-year old young man was referred to our hospital due to abnormal mass of mediastinum on chest radiography. Chest computed tomography scan revealed 45 mm mass in diameter with low density areas and ring shaped calcification at right upper mediastinum. However, chest magnetic resonance imaging showed no existence of fat nor calcification. Read More

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November 2017
7 Reads

[Primary mediastinal choriocarcinoma: A case report and literature review].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Oct;42(10):1222-1227

Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Primary mediastinal choriocarcinoma in male is not a very common disease, with nonspecific clinical manifestations. Gynecomastia and testicular atrophy are present in some cases. The levels of serum human chorionic gonadotropin are often significantly increased. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2017.10.016DOI Listing
October 2017
4 Reads

Phase II trial of pembrolizumab in patients with platinum refractory germ-cell tumors: a Hoosier Cancer Research Network Study GU14-206.

Ann Oncol 2018 01;29(1):209-214

Melvin & Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, USA.

Background: Despite remarkable results with salvage standard-dose or high-dose chemotherapy ∼15% of patients with relapsed germ-cell tumors (GCT) are incurable. Immune checkpoint inhibitors have produced significant remission in multiple tumor types. We report the first study of immunotherapy in patients with GCT. Read More

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http://academic.oup.com/annonc/article/29/1/209/4555286
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http://dx.doi.org/10.1093/annonc/mdx680DOI Listing
January 2018
10 Reads

Prediction of respiratory collapse among pediatric patients with mediastinal tumors during induction of general anesthesia.

J Pediatr Surg 2018 Jul 2;53(7):1365-1368. Epub 2017 Oct 2.

Department of Pediatric Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba 260-8677, Japan.

Purpose: Fatality resulting from respiratory collapse (RC) during general anesthesia (GA) induction in children with mediastinal tumors has been reported. We explored potentially useful parameters for predicting the risk of RC based on objective imaging results.

Methods: We retrospectively reviewed the records of 31 patients (median age: 4years; range: 4months-15years) with mediastinal tumors treated between 2000 and 2015. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2017.09.013DOI Listing
July 2018
10 Reads

Yolk sac primary tumor of mediastino: a rare case in a young adult.

Einstein (Sao Paulo) 2017 Oct-Dec;15(4):496-499. Epub 2017 Sep 21.

Instituto de Assistência Médica ao Servidor Público Estadual, Hospital do Servidor Público Estadual "Francisco Morato de Oliveira", São Paulo, SP, Brazil.

Germ cell tumors are rare neoplasms that mostly occur in the gonads, although they can also affect other body sites, especially the anterior mediastinum (50 to 70% of all extragonadal germ cell tumors). We report a case of a primary mediastinal yolk sac tumor, a rare and aggressive germ cell tumors subtype. This was a 38-year-old man who was admitted to Hospital do Servidor Público Estadual "Francisco Morato de Oliveira", complaining about dyspnea and dry cough for 1 year. Read More

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http://dx.doi.org/10.1590/S1679-45082017RC4008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875168PMC
March 2018
37 Reads

Mediastinal lesions across the age spectrum: a clinicopathological comparison between pediatric and adult patients.

Oncotarget 2017 Aug 18;8(35):59845-59853. Epub 2017 Apr 18.

Department of Pathology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

The objective of this study was to identify the differences in histopathological distribution and clinical features of mediastinal lesions (MLs) across the age spectrum in Chinese series of patients and to compare with the available literature. A total of 409 cases of MLs, including 137 pediatric and 272 adult patients from a single institution, was reviewed and categorized into groups according to age. Among the 409 cases, the age showed a bimodal distribution with an increased incidence of MLs among (< 10 year) and (60-< 70 year) age groups. Read More

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http://www.oncotarget.com/fulltext/17201
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http://dx.doi.org/10.18632/oncotarget.17201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601783PMC
August 2017
21 Reads
6.360 Impact Factor

Acquired Intermittent Pediatric Horner Syndrome due to Neuroblastoma.

Ophthalmic Plast Reconstr Surg 2018 Mar/Apr;34(2):e38-e41

Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts.

A 3-month-old male developed intermittent left upper eyelid ptosis at the age of 1 month that was gradually increasing in frequency and duration. Examination revealed anisocoria and left upper and lower eyelid ptosis, consistent with a left Horner syndrome. Imaging showed a mass in the left superior posterior mediastinum, which was resected, and pathology was consistent with neuroblastoma. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001001DOI Listing
July 2018
6 Reads

Distribution of malignant lymphomas in the anterior mediastinum: a single-institution study of 76 cases in Japan, 1997-2016.

Int J Hematol 2017 Nov 18;106(5):675-680. Epub 2017 Sep 18.

Department of Hematology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

We analyzed the distribution of tumors and lymphomas of the anterior mediastinum diagnosed between 1997 and 2016 at the National Cancer Center Hospital, Japan. The median age of 283 patients with anterior mediastinal tumors was 48 (range 6-84) years, and 143 (51%) were male. The incidence of tumors was as follows: thymoma, 34%; thymic carcinoma, 16%; primary mediastinal large B-cell lymphoma (PMBL), 13%; germ cell tumors, 10%; classical Hodgkin lymphoma (CHL), 9%; thymic cyst, 7%; metastatic tumors, 3%; T lymphoblastic leukemia/lymphoma (T-LBL), 2%; other lymphomas, 3%; and others, 3%. Read More

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http://dx.doi.org/10.1007/s12185-017-2331-0DOI Listing
November 2017
25 Reads

[Analysis of primary site and pathology on 903 patients with neuroendocrine neoplasms].

Zhonghua Wei Chang Wai Ke Za Zhi 2017 Sep;20(9):993-996

Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing 100029, China.

Objective: To explore the primary site and pathological feature of neuroendocrine neoplasm (NEN), especially the NEN of digestive system.

Methods: Clinicopathological data of NEN patients at China-Japan Friendship Hospital from January 2012 to December 2016 were retrospectively analyzed. Tumor primary sites were summarized. Read More

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September 2017
14 Reads

Massive Hemoptysis: A Rare Presentation of Anterior Mediastinal Teratoma in an Adolescent.

Indian J Med Paediatr Oncol 2017 Apr-Jun;38(2):215-217

Department of Paediatrics, Government Medical College, Nagpur, Maharashtra, India.

Germ cell tumors are predominantly found in the gonads, and the most common extragonadal site is anterior mediastinum. Usual symptoms are cough, dyspnea, and fever, chest pain due to mass effect or intrapulmonary invasion but hemoptysis is rare and may result from either communication with tracheobronchial tree or may result from bronchial bleeding due to irritation by tumor. As in our case, patient presenting with massive hemoptysis and shock are the rarest presentation of a benign teratoma. Read More

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http://dx.doi.org/10.4103/ijmpo.ijmpo_62_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582563PMC
September 2017
10 Reads

An analysis of clinical characteristics and patient outcomes in primary mediastinal sarcomas.

Expert Rev Anticancer Ther 2017 11 14;17(11):1071-1076. Epub 2017 Sep 14.

a Clinical Oncology Department, Faculty of Medicine , Ain Shams University , Cairo , Egypt.

Background: Published data concerning primary mediastinal sarcomas are limited to small-sized retrospective series.  This study reviewed the clinical outcomes of these cases from the SEER (surveillance, epidemiology and end results) database.

Methods: Primary mediastinal sarcomas (1988 - 2013) were assembled from the SEER database. Read More

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http://dx.doi.org/10.1080/14737140.2017.1378576DOI Listing
November 2017
7 Reads

Primary Mediastinal Pure Seminomatous Germ Cell Tumor (Germinoma) as a Rare Cause of Precocious Puberty in a 9-Year-Old Patient.

Urology 2017 Dec 6;110:216-219. Epub 2017 Sep 6.

Division of Urology, Hospital Universitario San Ignacio and Pontificia Universidad Javeriana School of Medicine, Bogotá D.C., Colombia; Department of Urology, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá D.C., Colombia.

Less than 5%-7% of germ cell tumors are extragonadal, with the central nervous system being the most common location in children, followed by retroperitoneum and mediastinum. Only 10% of mediastinal tumors are malignant and one-third of these are pure seminomas (germinomas). We report the case of a 9-year-old boy with development of secondary sexual characteristics. Read More

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http://dx.doi.org/10.1016/j.urology.2017.08.038DOI Listing
December 2017
19 Reads

Ganglioneuroma of the retropharyngeal space in a patient with glottic cancer.

BMJ Case Rep 2017 Sep 7;2017. Epub 2017 Sep 7.

Radiology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal.

We describe the case of a 71-year-old man with a ganglioneuroma of the retropharyngeal space. The patient presented with a submucosal bulge of the left oropharyngeal wall during follow-up examination of a treated vocal cord carcinoma. CT and MRI revealed a non-specific, well-defined retropharyngeal soft tissue lesion. Read More

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http://dx.doi.org/10.1136/bcr-2017-220966DOI Listing
September 2017
6 Reads

Successful treatment with doxorubicin and ifosfamide for mediastinal malignant peripheral nerve sheath tumor with loss of H3K27me3 expression.

Thorac Cancer 2017 11 6;8(6):720-723. Epub 2017 Sep 6.

Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

Malignant peripheral nerve sheath tumor (MPNST) in the thorax is an extremely rare disease, and half of all cases of MPNST are associated with neurofibromatosis type I. Sporadic intrathoracic MPNST is difficult to diagnose and treat. Because of the rarity of intrathoracic MPNST, the optimal method of diagnosis and the efficacy of chemotherapy are unknown. Read More

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http://dx.doi.org/10.1111/1759-7714.12498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668470PMC
November 2017
13 Reads

Ganglioneuroblastoma in a newborn with multiple metastases: a case report.

J Med Case Rep 2017 Aug 29;11(1):239. Epub 2017 Aug 29.

Department of Pathology, Manipal College of Medical Sciences, Pokhara, Nepal.

Background: Ganglioneuroblastoma is a tumor of peripheral neuroblastic tissue which occurs predominantly in the pediatric age group; it is a rare occurrence in the newborn period with only one case reported at birth to date.

Case Presentation: We report the case of a newborn male baby of Brahmin ethnicity from Nepal who presented with respiratory distress and blueberry muffin skin lesions after birth. A computed tomography scan showed a mass lesion in the posterior mediastinum, which was diagnosed as ganglioneuroblastoma on fine-needle aspiration cytology. Read More

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http://dx.doi.org/10.1186/s13256-017-1397-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574244PMC
August 2017
5 Reads

Surgical approaches, anaesthetic management and outcome in pediatric superior mediastinal tumors.

J Egypt Natl Canc Inst 2017 Sep 31;29(3):147-153. Epub 2017 Aug 31.

Surgical Oncology Department, Children's Cancer Hospital (CCHE), Egypt; Department of Surgery, National Cancer Institute, Cairo University, Egypt.

Background: Pediatric superior mediastinal tumors are a heterogeneous group of tumors with marked variation in pathology and extension. We reviewed our experience with different surgical approaches to tumors originating from or extending to superior mediastinum in pediatrics.

Patients And Methods: The medical records of all patients who had undergone resection for superior mediastinal tumors in Children's Cancer Hospital - Egypt, between January 2008 to December 2015, were reviewed for demographic data, clinico-pathological features, radiologic findings, operative techniques and outcome. Read More

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http://dx.doi.org/10.1016/j.jnci.2017.08.001DOI Listing
September 2017
6 Reads

Vagus nerve schwannoma in the right upper mediastinum.

Thorac Cancer 2017 11 14;8(6):698-702. Epub 2017 Aug 14.

Thoracic Surgery Department, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.

A 35-year-old woman was admitted to our hospital with an abnormal shadow on her chest roentgenogram. Computed tomography showed that a tumor was located in the right upper mediastinum. Resection of the tumor by video-assisted thoracoscopic surgery was performed. Read More

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http://dx.doi.org/10.1111/1759-7714.12485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668479PMC
November 2017
17 Reads

An Unusual Schwannoma.

J Assoc Physicians India 2017 Jun;65(6):92-94

Department of Pulmonary Medicine, TN Medical College, BYL Nair Hospital, Mumbai, Maharashtra.

Mediastinal masses are commonly encountered and have multiple differentials. Although histopathological examination is gold standard, the location of the mass narrows the diagnosis. While thyroid, thymus, germ cell tumour or lymph node related masses are common in superior mediastinum, vascular or pleuro-pericardial masses are seen in middle mediastinum. Read More

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June 2017
6 Reads

Verner-Morrison syndrome. Literature review.

Rom J Morphol Embryol 2017 ;58(2):371-376

Department of Pediatric Surgery, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania; Department of Neonatology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania;

Chronic diarrhea in infants is a common condition for addressability to pediatric gastroenterologists. The causes are multiple and the delay in reaching the final diagnosis can lead to complications in the general condition of the child. The purpose of this review is to present the bio-clinical and histogenetic particularities of a rare clinical entity, characterized by tumoral causes of chronic diarrhea. Read More

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April 2018
34 Reads

Quantitative analysis of normal and pathologic adrenal glands with 18F-FDOPA PET/CT: focus on pheochromocytomas.

Nucl Med Commun 2017 Sep;38(9):771-779

Departments of aNuclear Medicine bEndocrinology, GHE cEndocrine Surgery, GHS, CHU Lyon dDepartment of Nuclear Medicine eDermatology Unit, CLB Lyon fEA 3637, Lyon 1 University, Lyon, France gDepartment of Nuclear Sciences and Applications, Vienna International Centre, Division of Human Health, Nuclear Medicine and Diagnostic Imaging Section, International Atomic Energy Agency, Vienna, Austria.

Introduction: Many studies have reported the high performance of 6-fluorine-18-fluorodihydroxyphenilalanine (F-FDOPA) PET/CT in the diagnosis of pheochromocytomas but nobody seems to have investigated physiological and pathological adrenal glands from a quantitative point of view. The purpose of the present study was to assess the quantitative F-FDOPA uptake of normal and pathologic adrenal glands and to establish thresholds to characterize pheochromocytomas. We were especially interested in characterizing the remaining adrenal glands captation after an adrenalectomy. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000708DOI Listing
September 2017
23 Reads

[Seminoma of the Mediastinum with Cystic Change;Report of a Case].

Kyobu Geka 2017 Jul;70(7):545-547

Department of Thoracic Surgery, Higashihiroshima Medical Center, Hiroshima, Japan.

The patient was a 25-year-old man. He was diagnosed as having a mediastinal tumor based on chest radiography. Chest computed tomography and magnetic resonance imaging revealed a cystic tumor in the anterior mediastinum. Read More

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July 2017
23 Reads

Imaging of renal medullary carcinoma in children and young adults: a report from the Children's Oncology Group.

Pediatr Radiol 2017 Nov 8;47(12):1615-1621. Epub 2017 Jul 8.

Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway, Campus Box 8131, St. Louis, MO, 63110, USA.

Background: Renal medullary carcinoma is a rare renal malignancy of childhood. There are no large series describing the imaging appearance of renal medullary carcinoma in children.

Objective: To characterize the clinical and imaging features of pediatric renal medullary carcinoma at initial presentation. Read More

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http://dx.doi.org/10.1007/s00247-017-3926-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768308PMC
November 2017
14 Reads