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Curr Oncol Rep 2019 Jan 21;21(1). Epub 2019 Jan 21.

Department of Urology, Indiana University School of Medicine, 535 Barnhill Dr., Indianapolis, IN, 46202, USA.

Purpose Of Review: The purpose of this review is to educate medical oncologists on the management of patients with residual germ cell tumors and the role of surgical resection after platinum-based chemotherapy.

Recent Findings: Patients with non-seminomatous testicular cancer and residual enlarged retroperitoneal lymph nodes > 1 cm following induction chemotherapy with normal tumor markers should undergo a post-chemotherapy retroperitoneal lymph node dissection. All patients with primary mediastinal non-seminoma should undergo surgical resection of the mediastinal mass post-chemotherapy. Read More

Nihon Hinyokika Gakkai Zasshi 2018 ;109(1):40-44

Department of Urology, Nagoya University Graduate School of Medicine.

A 61-year-old man had undergone resection of teratoma with a histological component of seminoma occurring in the anterior mediastinum at 26 years of age in 1978, followed by radiation treatment to the resected area. He had a recurrence tumor in the left retroperitoneum 2 years later, which was resected combined with left nephrectomy and was proved to be the same pathology as the initial tumor. At 36 years after the initial treatment, the tumor recurred in the right lung. Read More

Kyobu Geka 2018 12;71(13):1077-1080

Division of Thoracic Surgery, Kobe University, Kobe, Japan.

A 21-year-old man was referred to our hospital because of an abnormal shadow on a routine chest radiogram. Enhanced computed tomography showed an 83×74 mm mass in the anterior mediastinum, with invasion of the superior vena cava (SVC). Surgical resection with sternotomy was performed. Read More

Diagn Cytopathol 2018 Nov 23. Epub 2018 Nov 23.

Department of Lab Medicine and Pathology - Histopathology Section, Hamad Medical Corporation, Doha, State of Qatar.

Germ cell tumors can occur in the mediastinum. They account for about 20% of tumors at this location. The majority are located in the anterior mediastinum and usually occur in young adult males. Read More

Thorac Cancer 2019 Jan 23;10(1):116-119. Epub 2018 Nov 23.

Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

A 44-year-old man was referred to our hospital after an anterior mediastinal tumor was noted on computed tomography during follow-up observation after left testicular seminoma resection. Chest computed tomography revealed an enhanced mass measuring 33 x 16 x 15 mm at the anterior mediastinum. Chest magnetic resonance imaging revealed high signal intensity on T2-weighted imaging, and F  fluorodeoxyglucose-positron emission tomography showed a maximum standardized uptake of 12. Read More

BMC Cancer 2018 Nov 3;18(1):1062. Epub 2018 Nov 3.

2nd Department of Oncology, Faculty of Medicine, Comenius University and National Cancer Institute, Klenova 1, 833 10, Bratislava, Slovak Republic.

Background: WNT/βcatenin (WNTβ) pathway is activated in early stages of embryonic development. We aimed to evaluate the significance of βcatenin in germ cell tumors (GCTs) and explore associations with the inflamed environment.

Methods: Surgical specimens from 247 patients were analyzed. Read More

Rev Port Cir Cardiotorac Vasc 2018 Jan-Jun;25(1-2):87-89

Cardiothoracic Surgery Department, Hospital Beatriz Ângelo, Loures, Portugal.

Primary mediastinal tumours with chest wall involvement represent technical challenges that may offer a survival benefit. Reconstruction with osteossynthesis material, bioprosthesis and muscle flaps is indicated to re-establish the excised component function. We report a case of a 30-year-old male with a primary mediastinal seminoma operated after chemotherapy with need for en bloc resection of the residual mass and manubrium with chest wall reconstruction. Read More

J Clin Oncol 2018 Oct 4:JCO1800210. Epub 2018 Oct 4.

Richard Cathomas, Kantonsspital Graubünden, Chur; Dirk Klingbiel, Swiss Group for Clinical Cancer Research Coordinating Center; Silke Gillessen, University of Bern; Jörg Beyer, Inselspital, Bern University Hospital, University of Bern, Bern; Christian Fankhauser, University of Zürich, Zürich; Silke Gillessen, Kantonsspital St Gallen, St Gallen, Switzerland; Brandon Bernard, Dana-Farber Cancer Institute, Boston, MA; Anja Lorch, University of Düsseldorf, Düsseldorf; Christoph Oing, University Medical Center Hamburg-Eppendorf, Hamburg; Marcus Hentrich, Rotkreuzklinikum München, München, Germany; Xavier Garcia del Muro, Institute Catalan of Oncology, Bellvitge Biomedical Research Institute, University of Barcelona, Barcelona, Spain; Franco Morelli, Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo; Ugo De Giorgi, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Istituto di Ricovero e Cura a Carattere Scientifico, Meldola, Italy; Mikhail Fedyanin, N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia; and Hege Sagstuen Haugnes, University Hospital of North Norway and Universitetet i Tromsø-The Arctic University, Tromsø, Norway.

Purpose: Residual lesions after chemotherapy are frequent in metastatic seminoma. Watchful waiting is recommended for lesions < 3 cm as well as for fluorodeoxyglucose (FDG) positron emission tomography (PET)-negative lesions ≥ 3 cm. Information on the optimal management of PET-positive residual lesions ≥ 3 cm is lacking. Read More

Asian J Endosc Surg 2018 Sep 5. Epub 2018 Sep 5.

Department of Pathology, Suwa Red Cross Hospital, Suwa, Japan.

Mediastinal seminoma is an uncommon tumor that accounts for 25% of primary mediastinal germ cell tumors, which in turn comprise fewer than 5% of all germ cell tumors. Although CT normally shows a solid, lobulated tumor, mediastinal cystic seminoma has rarely been described. Here, we report a 24-year-old man who presented with a mediastinal cystic tumor that was resected after an 18-month delay via video-assisted thoracoscopic surgery while in the supine position; the procedure involved lifting the chest wall with a subcutaneous Kirschner wire. Read More

J Thorac Dis 2018 Jul;10(7):4335-4341

Radiotherapy Department, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland.

Background: The objective of this study was to evaluate the long term treatment results of patients with primary mediastinal seminoma.

Methods: Sixteen patients aged 21-46 diagnosed with primary mediastinal seminoma between 1983 and 2014. Mean size of the tumor was 65 cm. Read More

J Thorac Dis 2018 Jun;10(6):E438-E441

Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Am J Case Rep 2018 Jun 29;19:763-766. Epub 2018 Jun 29.

Division of Medical Oncology, Mercy Hospital, Metz-Thionville Regional Hospital Center, Ars-Laquenexy, France.

BACKGROUND Myeloid sarcoma is a rare extramedullary soft tissue neoplasm composed of myeloblastic cells, usually associated to hematologic tumor disorders and a poor prognosis. Its diagnosis is very difficult as radiological images are not specific. Histology and immunohistochemistry are necessary for an accurate diagnosis. Read More

Hum Pathol 2018 Nov 16;81:26-36. Epub 2018 May 16.

Division of Clinical Pathology, Geneva University Hospitals, 1205 Geneva, Switzerland.

Identification of the yolk sac tumor (YST) component in germ cell tumors (GCT) may prove challenging, and highly sensitive and specific immunohistochemical markers are still lacking. Preliminary data from the literature suggest that HNF1β may represent a sensitive marker of YST. The specificity of HNF1β has not been addressed in GCT. Read More

Rev Esp Med Nucl Imagen Mol 2018 Sep - Oct;37(5):318-319. Epub 2018 Apr 7.

Nuclear Medicine Department, University Hospital of Larissa, Thessaly, Grecia.

J Thorac Dis 2018 Feb;10(2):E98-E102

Department of Radiology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

Primary mediastinal seminoma (PMS) is a rare tumor. PMS can be morphologically related to secondary changes in the form of thymic remnants, cystic degeneration, epithelioid granulomas, fibrotic change, and syncytiotrophoblast-like cells. Ours was an interesting case where a 26-year-old male presented with an incidentally-found anterior mediastinal mass. Read More

Clin Case Rep 2017 10 30;5(10):1658-1659. Epub 2017 Aug 30.

Department of Hematology/Oncology Maimonides Medical Center Brooklyn New York.

Synchronous presentation of seminoma and lymphoma is rare but has important ramifications for the treatment of both malignancies. Without clinical vigilance, this situation may be easily missed, leading to inappropriate management. We describe a patient with synchronous seminoma and Hodgkin's lymphoma and discuss the implication on his treatment. Read More

J Minim Access Surg 2017 Oct-Dec;13(4):286-290

Department of Thoracic Surgery, Glenfield Hospital, Leicester, LE3 9QP, UK.

Introduction: The incidental early-stage thymic mass presents a diagnostic challenge. Video-assisted thoracoscopic (VAT) thymectomy is an attractive but potentially morbid solution. The aim was to show it can be safely applied as a first-line modality in those with undiagnosed thymic enlargement with acceptable long-term results. Read More

BMJ Case Rep 2017 Aug 30;2017. Epub 2017 Aug 30.

Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Int J Surg Case Rep 2017 24;39:199-202. Epub 2017 Aug 24.

Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine, Aomori, Japan. Electronic address:

Introduction: Although spontaneous regression (SR) of anterior mediastinal seminoma is very rare with normalization of β-human chorionic gonadotropin (β-hCG) level, video-assisted thoracic surgery (VATS) is the most effective solution for definite diagnosis of indeterminate anterior mediastinal masses.

Diagnosis, Therapeutic Interventions, And Outcomes: A rare case of an asymptomatic 37-year-old man with an anterior mediastinal mass that was detected on a routine chest X-ray is presented. Computed tomography (CT) showed a large anterior mediastinal tumor with superior vena cava invasion and SR before VATS for definitive diagnosis. Read More

PLoS One 2017 16;12(8):e0183219. Epub 2017 Aug 16.

Department of Pediatric Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, P. R. China.

Objective: Primary malignant mediastinal germ cell tumors (MMGCTs) are rare in children and adolescents and have a poorer prognosis than their gonadal counterparts. We report a single institutional experience of a 10-year period of primary advanced MMGCTs treated with chemotherapy, followed by radiotherapy in those who had residual mass.

Methods: Children and adolescents with primary advanced MMGCTs between 2005 and 2014 were identified from the Cancer Center, Sun Yat-Sen University. Read More

Kyobu Geka 2017 Jul;70(7):545-547

Department of Thoracic Surgery, Higashihiroshima Medical Center, Hiroshima, Japan.

The patient was a 25-year-old man. He was diagnosed as having a mediastinal tumor based on chest radiography. Chest computed tomography and magnetic resonance imaging revealed a cystic tumor in the anterior mediastinum. Read More

BMJ Case Rep 2017 Jun 8;2017. Epub 2017 Jun 8.

Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

We present a rare cause of superior vena cava syndrome (SVC) in a previously healthy male aged 31 years. Malignancy was suspected due to unintentional weight loss and childhood exposure to radioactive fallout from a nuclear facility accident. A very large anterior mediastinal mass was identified and demonstrated to be an extragonadal seminoma. Read More

Acta Biomed 2017 04 28;88(1):82-85. Epub 2017 Apr 28.

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Background: The Primitive Extratesticular Seminoma is a very rare condition and represents 3% of germ cell tumors; it is an indeterminate origin disease, whose diagnosis is often complicated by a nonspecific and highly variable clinical finding.

Case Presentation: A caucasian 55 years old male, non-smoker, arrived to our centre with cough, severe respiratory distress and dysphagia, in a context of the superior vena cava syndrome. A Computed Tomography was performed, which shows the presence of a mediastinal anterior mass with aorto-pulmonary window and left paracardiac invasion. Read More

Oncol Lett 2017 Mar 2;13(3):1299-1302. Epub 2017 Jan 2.

Department of Oncology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.

Primary mediastinal seminoma is a rare extragonadal germ cell tumour that mainly occurs in males. The present study reports the case of a 27-year-old woman that presented with superior vena cava syndrome and a large mass in the mediastinum, which was diagnosed as primary female mediastinal seminoma. The patient received 6 cycles of cisplatin-based chemotherapy [4 cycles BEP chemotherapy (120 mg cisplatin, 0. Read More

World J Surg Oncol 2017 Apr 13;15(1):85. Epub 2017 Apr 13.

Second Department of Propedeutic Surgery, Laiko General Hospital, National and Kapodistrian University of Athens, Agiou Thoma 17, 11527, Athens, Greece.

Background: Mediastinal thymic seminomas are rare male germ cell tumors with extragonadal origin that appear predominately with a cystic appearance.

Case Presentation: A 22-year-old male was referred to our department for further investigation of a mediastinal mass discovered incidentally during routine chest X-ray. The patient has denied any symptoms including dyspnea, chest pain, cough, fever, dysphagia, hemoptysis, weight loss, and weakness. Read More

BMC Cancer 2017 Apr 13;17(1):266. Epub 2017 Apr 13.

Division of Medical Oncology, Candiolo Cancer Institute - FPO, IRCCS, Strada Provinciale 142 Km 3.95, 10060, Candiolo, TO, Italy.

Background: Nuclear protein in testis (NUT) midline carcinoma is a rarely diagnosed and potentially under-recognized type of squamous carcinoma that is considered one of the most aggressive human solid tumors. Alpha-fetoprotein elevation has been associated with chronic liver diseases and a limited number of cancers. In particular, in presence of a mediastinal mass in a young man, alpha-fetoprotein elevation is considered nearly pathognomonic of a non-seminoma germ-cell tumor. Read More

Forensic Sci Int 2017 Jan 14;270:e1-e4. Epub 2016 Oct 14.

Department of Pathology, Faculty of Medicine, Chiang Mai University, 110 Intawaroros Rd., Sribhoom, Chiang Mai 50200, Thailand. Electronic address:

It is well-known that cardiovascular disease is the most common cause of sudden unexpected death, especially in the young. However complete postmortem investigation performed by qualified forensic pathologists is crucial in establishing the exact cause and manner of death. Sudden death caused by a cardiac tamponade occurring secondarily to a primary mediastinal tumor is extremely unusual. Read More

Pediatr Blood Cancer 2017 Sep 17;64(9). Epub 2017 Mar 17.

Pediatric Hematology-Oncology Unit, Pellegrin Hospital, CHU Bordeaux, Bordeaux, France.

Purpose: To examine the clinical presentation, treatment and results in children and adolescents with primary mediastinal (PM) and retroperitoneal (RP) germ cell tumors (GCTs).

Methods: The TGM95 trial for malignant GCTs was conducted in France between 1995 and 2005 to evaluate a strategy adapted to prognostic factors with cisplatin-based chemotherapy and surgical management. We reviewed patients with TGCTs at PM and RP sites. Read More

Eur J Cancer 2017 05 4;76:1-7. Epub 2017 Mar 4.

Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany. Electronic address:

Introduction: Treatment options for patients with platinum refractory metastatic germ cell tumours (GCT) relapsing after high-dose chemotherapy and autologous stem cell transplantation are limited and survival is poor. Antibodies directed against programmed cell death protein-1 (PD-1) and programmed cell death ligand-1 (PD-L1) are currently assessed within clinical trials. We present updated data on our experience with checkpoint inhibitors as a compassionate use off-label treatment attempt for highly-pretreated patients with GCT and provide an overview of the current literature on PD-L1 expression in this rare tumour entity. Read More

J Pathol Transl Med 2017 Mar 2;51(2):165-170. Epub 2017 Feb 2.

Gyeongsang National University School of Medicine, Jinju, Korea.

Thymoma is the most common neoplasm of the anterior mediastinum and has malignant potential. Germ cell tumors (GCTs) found in the anterior mediastinum are usually benign, and malignant GCTs, such as seminomas, are rare. Histologically, mediastinal seminoma is indistinguishable from testicular seminoma except for site-associated morphological features such as lymphoid follicular hyperplasia. Read More

Thorac Cardiovasc Surg 2017 Aug 22;65(5):382-386. Epub 2017 Jan 22.

Department of Surgery, University Hospital Marburg, Marburg, Germany.

 Our pilot study describes our initial experience to do a laser resection of lung metastases under video-assisted thoracoscopic control via a minithoracotomy. With this approach, if needed, mediastinal lymphadenectomy is also possible.  In this study, 15 patients (11 men and 4 women, mean age: 60 years) with resectable lung metastases of different solid primary tumors (colorectal cancer in seven patients, melanoma in three patients, renal cell carcinoma in two patients, and one each with oropharyngeal cancer, breast cancer, and seminoma) were included. Read More

Surg Case Rep 2017 Dec 5;3(1). Epub 2017 Jan 5.

Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

An asymptomatic 26-year-old man received an annual medical check-up, and chest X-ray showed a protrusion of the aortopulmonary window. Chest computed tomography (CT) revealed an anterior mediastinal tumor and cysts with thin wall and septum enhancement. The preoperative diagnosis was cystic thymoma or malignant lymphoma. Read More

Rom J Morphol Embryol 2016 ;57(3):1045-1050

"Fundeni" Urological Surgery Discipline, 3rd Department, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Center for Uronephrology and Renal Transplantation, "Fundeni" Clinical Institute, Bucharest, Romania;

Introduction: Retroperitoneal seminoma is a very rare form of cancer, with embryological origin represented by primordial germ cells from the urogenital ridges left behind during the fetal development. Extragenital germ cell tumors can also occur in the mediastinum or the pineal gland. The aim of this paper is to outline the particularities and draw embryological, histopatological and treatment conclusions regarding extragonadal germ cell tumors. Read More

Ann Oncol 2017 03;28(3):576-582

Department of Oncology, Hematology and Bone Marrow Transplantation, University Medical Center Eppendorf, Hamburg, Germany.

Background: Bone metastases (BM) are rare in germ cell tumor (GCT) patients. Systematic data on risk factors, treatment and outcome are largely lacking.

Patients And Methods: A database created by an international consortium including 123 GCT patients with BM at primary diagnosis was retrospectively analysed. Read More

J Clin Oncol 2017 Apr 21;35(10):1096-1102. Epub 2016 Nov 21.

All authors: Indiana University School of Medicine, Indianapolis, IN.

Purpose Patients with relapsed metastatic germ cell tumor (GCT) can be cured with second-line and even third-line regimens. We report survival outcomes of patients treated with high-dose chemotherapy (HDCT) and peripheral-blood stem-cell transplantation (PBSCT) at Indiana University between 2004 and 2014. Patients and Methods We conducted a retrospective analysis of 364 consecutive patients with GCT who progressed after cisplatin-based combination chemotherapy and were subsequently treated with HDCT and PBSCT. Read More

Oncol Res Treat 2016 20;39(11):688-694. Epub 2016 Oct 20.

Holistic Center for Cancer Study and Care (HOCC), Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat-Yai, Thailand.

Background: Cisplatin-based chemotherapy followed by surgical resection of the residual tumor remains the standard of care for patients with mediastinal germ cell tumors (MGCTs). To prevent pulmonary complications, a non-bleomycin-containing regimen is generally preferred. This study aims to review the clinical characteristics and outcomes of these patients. Read More

Hinyokika Kiyo 2016 Sep;62(9):489-493

The Department of Urology, The Department of Internal Medicine, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba.

We reported two cases of hyperthyroidism that developed during induction chemotherapy for advanced germ cell tumors with high serum human chorionic gonadotropin (hCG) levels. Case 1 : An 18-year-old man with mediastinal choriocarcinoma complained of tachycardia and tremor. His pretreatment serum hCG level was 1. Read More

Zhongguo Fei Ai Za Zhi 2016 Sep;19(9):636-40

Department of Thoracic Surgery, General Hospital of Lanzhou Army, Lanzhou 730050, China.

Primary mediastinal seminoma is a kind of germ cell malignancy outside the gonads, and it's rarer with sarcoma component. This disease which has no special clinical manifestations and imaging characteristics is difficult to identify with other mediastinal tumors and mediastinal type lung cancer. This paper reported a case of primary mediastinal seminoma with mediastinal sarcoma. Read More

Indian J Pathol Microbiol 2016 Jul-Sep;59(3):351-4

Department of Radiodiagnosis and Imaging, Armed Forces Medical College, Command Hospital, Pune, Maharashtra, India.

Primary mediastinal seminomas are rare tumors. Morphologically, they can be associated with secondary changes in the form of thymic remnants, cystic change, epithelioid granulomas, abundant fibrosis, and syncytiotrophoblast like cells. Ours was an interesting case where a 17-year-old adolescent male presented with anterior mediastinal mass. Read More

Pathol Int 2016 Sep 23;66(9):540-2. Epub 2016 Jul 23.

Department of Pathology, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan.

Rare Tumors 2016 Jun 28;8(2):6241. Epub 2016 Jun 28.

N.N. Blokhin Russian Cancer Research Center , Moscow.

Nuclear protein of the testis (NUT) midline carcinomas are rare aggressive carcinomas characterized by chromosomal rearrangements that involve the gene encoding the NUT. This article reviews the clinicopathologic features and the differential diagnosis of these malignancies. Read More

Oncol Lett 2016 Jul 16;12(1):348-350. Epub 2016 May 16.

Department of Internal Medicine, Qingdao Central Hospital, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao, Shandong 266042, P.R. China.

Primary mediastinal seminoma often occurs in the anterior mediastinum of young males. It is unusual for the tumor to originate in the middle or posterior mediastinum, and such cases have rarely been reported in the English literature. The present study reports the case of a 52-year-old man with a 3. Read More

Oncol Lett 2016 May 23;11(5):2971-2976. Epub 2016 Mar 23.

Department of Pathology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China.

Although primary central nervous system (CNS) germ cell tumors (GCTs) are one of the most treatable types of malignant brain tumor, a subset of patients remain resistant to standard chemotherapy. Gain-of-function mutations of the -Kit gene, and KIT protein expression, have been observed in a number of GCTs, including testicular seminoma, ovarian dysgerminoma and mediastinal seminoma in various ethnic groups. Although a small number of studies have reported the role of -Kit in CNS GCTs, few have focused on Chinese patients exhibiting CNS GCTs. Read More

Mod Pathol 2016 06 26;29(6):591-8. Epub 2016 Feb 26.

Department of Pathology, Mount Sinai Medical Center, New York, NY, USA.

Although the function of zinc finger and BTB domain containing 16 (ZBTB16) in spermatogenesis is well documented, expression of ZBTB16 in germ cell tumors has not yet been studied. The aim of this study was to investigate the immunohistochemical expression and diagnostic utility of ZBTB16 in germ cell tumors. A total of 67 adult germ cell tumors were studied (62 testicular germ cell tumors, 2 ovarian yolk sac tumors, 1 mediastinal yolk sac tumor, and 2 retroperitoneal metastatic yolk sac tumors). Read More

J Clin Diagn Res 2015 Dec 1;9(12):ED11-2. Epub 2015 Dec 1.

Post Graduate Student, Department of Pathology, Government Medical College , Amritsar, Punjab, India .

Extra-gonadal Germ cell tumours (EGCTs) are germ cell tumours that are found in locations other than the gonads. These tumours are seen in young males in the midline, mostly in the mediastinum followed by retroperitoneum, pineal gland, and sacrococcygeal area. While most of these are non-seminomatous, few are seminomatous. Read More

Conn Med 2015 Oct;79(9):527-30

Primary mediastinal germ cell tumors are relatively rare and represent 10% - 20% of all mediastinal tumors. About one-third of these are primary mediastinal seminomas, occurring in males in their third and fourth decades, with the median age of presentation ranging between 20 and 30 years of age. We report an unusual case of a 69-year old male with mediastinal seminoma, who presented at an age much higher than the usual affected patient and responded well to the conventional mode of therapy for this tumor. Read More

Oncol Lett 2015 Oct 11;10(4):2323-2326. Epub 2015 Aug 11.

Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China.

Primary extragonadal germ cell tumors are rare, and 60% of such cases are seminomas. While the tumors can occur in the mediastinum, thymus, retroperitoneal organs and pineal gland, seminoma originating in the prostate tissue is extremely rare. The present study reports the case of a 54-year-old male with prostate seminoma. Read More

Anticancer Res 2015 Nov;35(11):6325-7

Department of Cardiovascular and Thoracic Surgery, Rush University Medical Center, Chicago, IL, U.S.A.

We report a case of a young male who presented with an unresectable, centrally-located classic biphasic pulmonary blastoma (CBPB) involving his bilateral mainstem bronchi and esophagus and a synchronous right testicular seminoma. CBPB is a rare and aggressive tumor that most commonly presents as a solitary mass in the periphery of the lung. Surgical resection is the preferred treatment for CBPB, as chemotherapy and radiation have demonstrated limited effectiveness. Read More

Intern Med 2015 1;54(15):1909-12. Epub 2015 Aug 1.

Department of Respiratory Medicine, Fukuoka University Hospital, Japan.

A 22-year-old man was admitted following the detection of right hilar enlargement during a medical checkup. The patient's serum angiotensin-converting enzyme (ACE) level was abnormally high, and a needle aspiration biopsy showed non-caseating epithelioid cell granulomas. Surgical resection was performed, and the resected specimens showed irregularly shaped seminoma nests with intervening stroma consisting of epithelioid cell granulomas. Read More

Int J Clin Exp Pathol 2015 1;8(5):5650-7. Epub 2015 May 1.

Department of Pathology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University 160 Pujian Road, Shanghai 200127, China.

Primary extragonadal malignant germ cell tumors (EMGCTs) are rare and characterized by the location in the midline of the body, including mediastinum, CNS, retroperitoneum and coccyx. EMGCTs present with different clinical and biologic characteristics in different tumor locations. Accurately diagnosing MEGCTs would be very difficult by performing on HE staining alone, and requires immunohistochemical verification. Read More