Search Our Scientific Publications & Authors

Brain Tumor Res Treat 2020 Jun 29. Epub 2020 Jun 29.

Department Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Teratomas are benign germ cell tumors that usually found out of their anatomical origin. Teratomas usually are found in sacrococcygeal area, gonads, mediastinum, cervicofacial region and intracranial fossa. Spinal teratomas are rare. Read More

Radiol Case Rep 2020 Jul 21;15(7):1058-1065. Epub 2020 May 21.

University Medical Center at Ho Chi Minh City, 215 Hong Bang Street, District 5, Ho Chi Minh City 72714, Vietnam.

Mature cystic teratoma (MCT) is a benign, slow-growing tumor and accounts for approximately 75% of mediastinal germ cell tumors. Patients with MCT are often asymptomatic when the tumors are small. Most of the symptoms are frequently related to compression of the mediastinal structures. Read More

Cureus 2020 Apr 11;12(4):e7637. Epub 2020 Apr 11.

Medical Oncology, Larkin Community Hospital, Miami, USA.

Cryptorchidism is an undeniable risk factor for testicular germ cell tumors (TGCTs) and is also commonly associated with Klinefelter syndrome (KS) patients. Embryonal cell carcinoma usually shows strong expression of CD30 and OCT3/4, with patchy staining of PLAP1. Most patients with nonseminomatous GCTs (NSGCTs) can achieve total remission with proactive chemotherapy, and most can be cured. Read More

Ann Emerg Med 2020 05;75(5):e27-e28

Division of Emergency Medicine, Department of Surgery, Duke University Hospital, Durham, NC.

Monaldi Arch Chest Dis 2020 Apr 8;90(1). Epub 2020 Apr 8.

Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples.

Testicular carcinoma recurrences represent a rare finding (1-6% in non-seminomatous germ cell tumours). However, cases of recurrence have been described many years later. We report a case of late recurrence of embryonic testicular carcinoma, after 26 years, with pulmonary metastases. Read More

J Med Vasc 2020 Apr 6;45(2):90-92. Epub 2020 Feb 6.

Inserm UMRS_1166, Institute of Cardiometabolism and Nutrition, GRC 27 GRECO, Sorbonne Université, 75013 Paris, France; Biological hematology department, Pitié-Salpêtrière Hospital, AP-HP, 75013 Paris, France; Groupe francophone thrombose et cancer, 75010 Paris, France. Electronic address:

Am J Med Sci 2020 05 14;359(5):308-309. Epub 2019 Dec 14.

Department of Radiology, Affiliated Hospital of Southwest Medical University, LuZhou, SiChuan, China. Electronic address:

Cureus 2020 Feb 28;12(2):e7131. Epub 2020 Feb 28.

Internal Medicine, King Edward Medical University/Mayo Hospital, Lahore, PAK.

Multiple different types of mediastinal masses may be encountered on imaging techniques in symptomatic and asymptomatic patients. The most frequent mediastinal masses in adults are thymoma, lymphoma, thyroid masses, and germ cell tumors. Potential complications of these masses due to localized invasion include hemoptysis, post-obstructive pneumonia, and superior vena cava syndrome. Read More

Ann R Coll Surg Engl 2020 Jul 1;102(6):e133-e135. Epub 2020 Apr 1.

The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Ganglioneuroma is a rare benign neoplasm. Patients with ganglioneuroma show no symptoms. We describe a rare case of giant ganglioneuroma with scoliosis in a 35-year-old woman, who presented to our hospital for haemoptysis. Read More

Case Rep Radiol 2020 25;2020:7650206. Epub 2020 Feb 25.

Radiology Department, Thoracic Imaging Division, Hospital Universitario Mayor - Méderi, Universidad del Rosario, Bogotá, Colombia.

Germ cell tumors account for 15% of anterior mediastinum tumors. Fistulas are abnormal communications between two surfaces covered by the epithelium. A fistula can occur between the bronchial tree and the adjacent anatomical structures secondary to variable etiologies. Read More

Indian J Radiol Imaging 2019 Oct-Dec;29(4):472-476. Epub 2019 Dec 31.

Department of Radiodiagnosis, Shri M.P. Shah Government Medical College and Shri Gurugobind Singh Government Hospital, P.N. Marg, Jamnagar, Gujarat, India.

Teratomas are germ cell tumors which are mainly gonadal in origin. Other common extra-gonadal sites are mediastinal, sacro-coccygeal and pineal regions. Adrenal teratomas are extremely rare and primary adrenal teratomas are even rarer. Read More

Int J Clin Exp Pathol 2019 1;12(8):3082-3088. Epub 2019 Aug 1.

Department of Pathology, West China Hospital of Sichuan University Chengdu, China.

Primary mediastinal thymoma combined with germ cell tumor (GCT) is extremely rare, and is likely to be misdiagnosed. Here we report a case of mediastinal type B3 thymoma combined with seminoma in which the seminoma component was missed by histologic examination and initially diagnosed by using a pleural effusion sample. The patient was a 46 year old male with chest distress, cough, and supraclavicular lymph node enlargement. Read More

Turk J Pediatr 2019 ;61(3):456-459

Divisions of Radiology, Ankara Children's Hematology and Oncology Education and Research Hospital, Ankara, Turkey.

Özyörük D, Kocayozgat A, Yaman-Bajin İ, Çetindağ F, Oğuz- Erdoğan AS, Güneş A. A synchronous occurrence of bifocal intracranial germinoma and bilateral testicular epidermoid cyst in an adolescent patient with Klinefelter`s syndrome. Turk J Pediatr 2019; 61: 456-459. Read More

BMJ Case Rep 2019 Dec 29;12(12). Epub 2019 Dec 29.

Department of Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA.

In the setting of severe septic shock, a 70-year-old woman had an ST segment myocardial infarction with ST elevations in the inferolateral leads. On cardiac catheterisation, no obstructive pathology was noted. Chest imaging revealed a large mediastinal mass measuring 8. Read More

BMC Cancer 2019 Dec 30;19(1):1265. Epub 2019 Dec 30.

Division of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, No.386, Ta-Chung 1st Rd, 81362, Kaohsiung, Taiwan.

Background: Ganglioneuromas (GNs) are composed of mature ganglion cells and Schwann cells with a fibrous stroma; GNs are most often observed in children and young adults. The majority of non-cranial GNs are located in the retroperitoneum and posterior mediastinum. Other reported rare sites include the adrenal gland, small intestine, colon and urinary bladder. Read More

Kyobu Geka 2019 Dec;72(13):1072-1075

Department of Thoracic Surgery, Hyogo Cancer Center, Akashi, Japan.

A 69-year-old man with hypertension was referred for an abnormal shadow detected on chest computed tomography(CT) at a medical checkup. Enhanced CT showed a highly enhanced posterior mediastinal tumor of 34×27 mm. Magnetic resonance imaging (MRI) revealed a low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. Read More

Neurosciences (Riyadh) 2019 Oct;24(4):320-323

Department of pediatrics, College of Medicine, University of Mosul, Mosul, Iraq. E-mail:

Neuroblastoma is an embryonic tumor of the sympathetic nervous system originating from neural crest cell remnants, which may be found in the adrenal glands or sympathetic chain. We report a case of a three-year-old girl who presented with flaccid paraparesis, and acute respiratory distress that required mechanical ventilation after a multiple-day history of gradual-onset dyspnea and right upper-lung opacity that was initially misdiagnosed as pneumonia. Chest and spinal magnetic resonance imaging (MRI) revealed a tumor in the posterior mediastinum with intra-spinal canal extension. Read More

BMJ Case Rep 2019 Nov 21;12(11). Epub 2019 Nov 21.

Department of Pathology, Rigshospitalet, Copenhagen, Denmark.

We report a rare case of isolated mediastinal and inferior mediastinal lymph node metastases from choroidal melanoma. The patient was treated for primary choroidal melanoma with local tumour resection and radioactive plaque brachytherapy. Eleven years later, he was diagnosed with metastatic disease. Read More

Ann Thorac Surg 2020 03 7;109(3):e229. Epub 2019 Nov 7.

Lung Cancer Center, West China Hospital of Sichuan University, Chengdu, China. Electronic address:

Medicine (Baltimore) 2019 Nov;98(44):e17686

Department of Thoracic Surgery and Pathology, Dongguan People's Hospital of Southern Medical University.

Rationale: Ependymomas are neuroepithelial tumors that typically occur in the central nervous system. Ependymomas arising in the mediastinum are exceedingly rare, with only approximately 9 isolated cases reported in the literature to date.

Patient Concerns: A 35-year-old woman was referred to our hospital with complaints of progressive back pain for 3 months. Read More

J Cardiothorac Surg 2019 Oct 29;14(1):182. Epub 2019 Oct 29.

Department of Thoracic Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.

Background: The authors presented a 63-year old female synchronously complicated with a thymic tumor located at the left-side of the superior mediastinum, and a paravertebral tumor located at the right-side of the lower thorax. Conventional thoracoscopic surgical procedure using rigid instruments to simultaneously resect the two tumors via the same ports might be technically challenging. To our knowledge, the use of a surgical robot allowed the surgeon to perform precise dissection from extreme angles with the characteristic of articulating surgical instruments. Read More

Surg Endosc 2020 02 28;34(2):1019-1023. Epub 2019 Oct 28.

Department of Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

Background: Growing teratoma syndrome is a rare condition defined by the presence of enlarging metastatic lesions on serial imaging that arise after or during systemic chemotherapy for nonseminomatous germ cell tumors. Lesions commonly occur in the retroperitoneum, mediastinum, or lung and are notoriously unresponsive to conventional chemoradiotherapy.

Methods: In this study, we present a dynamic case of a 26-year-old male, who had undergone surgical resection and systemic bleomycin treatment for a metastatic nonseminomatous germ cell tumor, and later developed recurrent masses in his posterior mediastinum seen on surveillance imaging. Read More

Medicine (Baltimore) 2019 Sep;98(39):e17145

Department of Orthopaedic Surgery.

Rationale: Paragangliomas are rare neuroendocrine tumors that originate in specialized cells derived from the neural crest with metastasis to the thoracic spine being among the rarest forms. Here, we are presenting a detailed analysis of a case of malignant paraganglioma in the thoracic spinal region in a 14-year-old boy. Our focus is to emphasize the importance of considering malignant paraganglioma as a diagnosis and guiding the perioperative management upon surgical treatment. Read More

Ann Thorac Surg 2020 05 27;109(5):e367-e369. Epub 2019 Sep 27.

Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri.

Aorticopulmonary paragangliomas are rare middle mediastinal masses that are often treated with surgery. In addition to the technical challenge of resection due to location near critical structures, these paragangliomas can have postoperative complications due to resection of cardiac sympathetic innervation. We present a patient with a nonfunctional aorticopulmonary paraganglioma who suffered from postoperative hypotension and heart block, with inability to tolerate his prior alpha and beta blockade on discharge. Read More

Am Surg 2019 Aug;85(8):e394-e395

Cureus 2019 Jun 19;11(6):e4941. Epub 2019 Jun 19.

Anesthesiology, Lokmanya Tilak Municipal Medical College & General Hospital, Mumbai, IND.

Mature teratoma of the mediastinum poses a significant surgical challenge due to close vicinity to vital structures causing respiratory insufficiency or hemodynamic compromise. While the malignant variety of germ cell tumors (GCT) generally present with florid symptoms, benign teratomas are detected incidentally on imaging. Large teratomas presenting as mediastinal mass syndrome have additional difficulty in airway access. Read More

Asian Cardiovasc Thorac Ann 2019 Oct 9;27(8):698-702. Epub 2019 Aug 9.

Apollo Hospitals, Chennai, India.

Medicine (Baltimore) 2019 Aug;98(32):e16732

Division of Pediatric Pulmonology.

Medical decisions should be well-planned to improve prognosis and reduce complications of mediastinal tumors. In this study, we analyzed the clinical presentations of pediatric mediastinal tumors and their correlation with long-term clinical outcome.Forty patients under 18 years of age diagnosed with mediastinal tumors at China Medical University Children's Hospital between 2001 and 2016 were enrolled. Read More

J Coll Physicians Surg Pak 2019 Aug;29(8):778-779

Department of Radiology, Alanya Alaaddin Keykubat University, Alanya Education and Research Hospital, Oba District, Alanya/Antalya, Turkey.

Teratomas are germ cell tumors arising from the embryonic germ layers. Since they originate from the germ cells, they can be found in the gonadal, sacrococcygeal, mediastinal, intracranial, retroperitoneal, and cervical regions. In this case report, a 4-year boy, brought to the hospital due to abdominal pain and fever, was diagnosed as a large and infected peritoneal teratoma by contrast-enhanced abdominal computed tomography (CT) along with abdominal CT and operative findings. Read More

Medicine (Baltimore) 2019 Jul;98(30):e16582

Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin.

Rationale: The presence of a mediastinal neurilemmoma accompanied by intrapulmonary sequestration is a rare occurrence. The clinical symptoms of a neurilemmoma depend on the site of the tumor. Diagnosis of pulmonary sequestration mainly depends on the presence of aberrant feeding arteries. Read More

Clin Nucl Med 2019 Sep;44(9):e519-e521

From the Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD.

A 57-year-old man with stage IIIB malignant melanoma of unknown primary presented for pretherapy FDG PET/CT that demonstrated metastatic left cervical lymph node with no other site of involvement. Following left neck dissection, nivolumab was initiated. Follow-up FDG PET/CT 3 months after initiation of nivolumab demonstrated extensive radiotracer-avid chest lymphadenopathy and multiple bone lesions. Read More

Med Sci Monit 2019 Jul 15;25:5263-5271. Epub 2019 Jul 15.

Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China (mainland).

BACKGROUND This study evaluated the imaging features of ganglioneuroma (GN) and assessed the diagnostic value of the enhancement rate (ER) of CT for GN. MATERIAL AND METHODS We retrospectively reviewed records of 49 patients with histopathologically confirmed GN who underwent preoperative contrast-enhanced CT or MRI between 2010 and 2018. The independent samples t test and chi-square test were used. Read More

Medicine (Baltimore) 2019 Jul;98(28):e16411

Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Rationale: Choriocarcinoma is a rare and highly invasive gestational trophoblastic tumor that secretes high levels of human chorionic gonadotropin (hCG). As one of the uncommon non-gestational choriocarcinoma, primary mediastinal choriocarcinoma is an exceeding rare, and aggressive malignancy with poor prognosis.

Patient Concerns: A 26-year-old man was admitted to the hospital with cough, shortness of breath, and occasional hemoptysis. Read More

J Pediatr 2019 11 11;214:231. Epub 2019 Jul 11.

Pediatric Neurology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Hum Pathol 2019 09 4;91:69-76. Epub 2019 Jul 4.

Department of Pathology, Division of Cytopathology, Johns Hopkins School of Medicine, Baltimore, MD 21287. Electronic address:

Immune checkpoint inhibitors are a major breakthrough in the field of oncology. Targets for approved immune checkpoint inhibitors are cytotoxic T-lymphocytes-associated antigen 4 (CTLA-4) and programmed cell death receptor 1/ programmed cell death ligand 1 (PD-1/PD-L1). Five patients (four males and one female) were treated with immune checkpoint inhibitors for advanced melanoma (stage III). Read More

Kyobu Geka 2019 Jun;72(6):450-453

Department of Thoracic Surgery, Mie Chuo Medical Center, Tsu, Japan.

The patient was a 34-year-old female and was 32 weeks pregnant. She was admitted to our department because of mediastinal cyst with infection. She complained of chest pain. Read More

J Cardiothorac Surg 2019 Jun 20;14(1):113. Epub 2019 Jun 20.

Department of Thoracic surgery, Peking Union Medical College Hospital, Peking Union Medical College, Dongcheng District, Beijing, 100730, China.

Background: Extralobar sequestration is a rare congenital malformation of lung tissue, which can be combined with other foregut and cardiac abnormalities. Our case is the first to report extralobar sequestration, absence of pericardium and atrial septal defect in the same patient.

Case Presentation: A 22-year-old female with atrial septal defect came for her recent atypical symptom of intermittent palpitation and shortness of breath. Read More

J Pak Med Assoc 2019 Jun;69(6):902-904

Pakistan Institute of Medical Sciences, Islamabad.

We report a case of a 28 year old female who presented to us in November 2016 with a swelling in front of neck for three years and worsening shortness of breath for last one year, causing right sided tracheal deviation and mildSuperior Vena Caval obstruction. X-ray showed a soft tissue density mass in antero-superior mediastinum with cephalad extension. Contrast enhanced CT neck and chest revealed a multi cystic lesion extending from the root of neck to anterior mediastinum causing compression and deviation of trachea, and nearby structures especially Superior Vena Cava (SVC) along with collateral formation. Read More

Monaldi Arch Chest Dis 2019 May 30;89(2). Epub 2019 May 30.

Department of Thoracic Surgery, Tenon University Hospital, Paris.

Schwannomas or neurilemmomas are benign tumors developed from the peripheral nervous system. Complete video-assisted thoracic surgery (cVATS) has set itself over the years as the preferred approach for the removal of small mediastinal neurogenic tumors. However, in case of apical location, complete VATS seems challenging because of proximity with the subclavian artery and/or elements of the brachial plexus. Read More

Neurol Sci 2019 Sep 30;40(9):1985-1989. Epub 2019 May 30.

Czech Centre for Phenogenomics and Laboratory of Transgenic Models of Diseases, Division BIOCEV, Institute of Molecular Genetics of the AS CR, v. v. i, Prague, Vestec, Czech Republic.

Introduction: Neuroblastoma ranks third among pediatric malignancies.

Case Report: The case of a 3-year-old child is presented, who suddenly had frequent, unproductive, emetic cough; fever; and weight loss. Lung X-ray showed an opacity situated in the posterior superior mediastinum. Read More

J Cardiothorac Surg 2019 May 22;14(1):96. Epub 2019 May 22.

Department of Surgery, University of Arizona, College of Medicine, Phoenix, AZ, USA.

Background: This case highlights the challenges of preoperative differential diagnosis and management in a patient with an uncommon clinical presentation of giant intrathoracic teratoma. The age of the patient, location and size of the tumor, and clinical presentation makes this case unique. Typically, intrathoracic teratomas are found between the ages of 20-30, they are located in the anterior mediastinum, and tumors larger than 25 cm clinically present with cough or dysphagia. Read More

World Neurosurg 2019 Aug 15;128:289-294. Epub 2019 May 15.

Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.

Background: Ganglioneuroma is a well-differentiated benign tumor that develops from the ganglion cells of the posterior mediastinum, retroperitoneum, cervical spine, and adrenal glands. The paravertebral body, in which the sympathetic trunk exists, is a common tumor site, and tumor sometimes invades the spinal canal through the intervertebral foramen. There have been no reports regarding tumors with intradural and extradural continuity. Read More

BMJ Case Rep 2019 May 10;12(5). Epub 2019 May 10.

Department of Pathology, Sri Ramachandra University Medical College, Chennai, Tamil Nadu, India.

Ancient schwannoma is a distinctive type of schwannoma occurring mostly in the retroperitoneum. The presentation in the posterior mediastinum is rare. The term 'ancient' represents a group of neurogenic tumours showing degenerative changes with marked nuclear atypia. Read More

BMJ Case Rep 2019 May 8;12(5). Epub 2019 May 8.

Medicine - Pulmonary Medicine, Jamaica Hospital Medical Center, Jamaica, New York, USA.

A 45-year-old man presents with acute respiratory failure. Imaging revealed a left mainstem endobronchial mass with subcarinal lymphadenopathy, but no other evidence of a primary tumour. An incidental laryngeal nodule was found during bronchoscopy. Read More

Medicine (Baltimore) 2019 Apr;98(15):e15203

Department of Otolaryngology-Head and Neck Surgery, First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin Province, China.

Rationale: Ganglioneuromas are benign neoplasm of neuroblastic origin which arise from central or peripheral parts of the autonomic nervous system. They are normally found at posterior mediastinum, retroperitoneum, and the adrenal gland but ganglioneuromas are rarely found in the cervical region.

Patient Concerns: A 12-year-old boy was admitted with a left-lateral neck mass slow growing over a 7-days duration. Read More

Semin Thorac Cardiovasc Surg 2019 11;31(4):870-872. Epub 2019 Apr 11.

Division of Thoracic Surgery, MedStar Georgetown University Hospital, Washington, District of Columbia.

PMNGCT is an independent predictor of poor prognosis despite advances in multidisciplinary management. Multidrug chemotherapy followed by aggressive surgical resection remains the mainstay of treatment. Although associated with significant morbidity, an open surgical approach is traditionally used. Read More

Endocr Pract 2019 Mar;25(3):211-219

Objective: Most of the Indian studies on pheochromocytoma/paraganglioma (PCC/PGL) have focused on PCC, and there is a paucity of information regarding sympathetic paraganglioma (sPGL). Here, we describe the clinical, biochemical, and imaging features of sPGL compared with PCC.

Methods: This retrospective study included 75 patients with sPGL and 150 patients with PCC. Read More

Oncology (Williston Park) 2019 Mar;33(3):107-9

J Pediatr Endocrinol Metab 2019 Apr;32(4):403-407

Consultant Paediatric Endocrinologist, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK.

Context Germ cell tumours (GCTs) secreting β-human chorionic gonadotropin (β-HCG) are a rare cause of gonadotropin-independent precocious puberty (GIPP). Case description A 5.7-year-old boy presented with GIPP. Read More

Niger J Clin Pract 2019 Mar;22(3):342-349

Department of Medical Oncology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu, P. R. China.

Background: Primary malignant mediastinal germ cell tumors (PMMGCTs) including seminomas and nonseminomatous germ cell tumors (NSGCTs) are rare, and sometimes the diagnosis is very difficult.

Purpose: The purpose of this study is to compare the clinical characteristics, biomarkers, and imaging findings of seminomas and NSGCTs and to determine whether these features could help distinguish these two types of PMMGCT.

Material And Methods: A retrospective study of 24 male patients with histopathologically proven PMMGCT was performed. Read More