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Diabetes Res Clin Pract 2021 May 11:108859. Epub 2021 May 11.

Department of Medicine, Division of Endocrinology, Diabetes & Metabolism, Johns Hopkins School of Medicine, Baltimore, MD, USA; Welch Prevention Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA. Electronic address:

Aim: To evaluate the associations of microvascular disease (MVD) with incident cardiovascular disease (CVD) in individuals with type 2 diabetes.

Methods: A total of 4098 participants with type 2 diabetes and without CVD were assessed for MVD (diabetic kidney disease, retinopathy or neuropathy) in the Look AHEAD (Action for Health in Diabetes) study. Cox models were used to generate hazard ratios (HRs) for: (1) CVD composite (myocardial infarction, stroke, hospitalization for angina and/or death from cardiovascular causes), (2) coronary artery disease (CAD), (3) stroke, and (4) CVD-related deaths. Read More

Front Neurol 2021 27;12:627183. Epub 2021 Apr 27.

Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Nitrous oxide (NO), commonly known as laughing gas, is inhaled recreationally because it produces the feelings of euphoria and freedom from pain. The risk of neurological dysfunction secondary to NO abuse and its clinical diagnosis are, however, not yet sufficiently recognized, especially in China. Here, we have summarized the key clinical characteristics of NO-induced neurological disorders. Read More

J Pharmacol Exp Ther 2021 May 13. Epub 2021 May 13.

University of California Irvine, United States

N-acylethanolamine acid amidase (NAAA) is an N-terminal cysteine hydrolase that stops the physiological actions of palmitoylethanolamide (PEA), an endogenous lipid messenger that activates the transcription factor, peroxisome proliferator-activated receptor-α. We have previously reported that the compound ARN19702 ((2-ethylsulfonylphenyl)-[(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone) is an orally active, reversible NAAA inhibitor (median inhibitory concentration, IC, on human NAAA = 230 nM) that produces remarkable protective effects against multiple sclerosis in mice. In the present study, we assessed the profile of ARN19702 in mouse and rat models of acute and neuropathic pain. Read More

JAMA Otolaryngol Head Neck Surg 2021 May 6. Epub 2021 May 6.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston.

Importance: Voice and speech production are critical physiological functions that affect quality of life and may deteriorate substantially after oropharyngeal cancer (OPC) treatment. There is limited knowledge about risk factors associated with voice and speech outcomes among survivors of OPC.

Objective: To identify the risk factors of voice and speech symptoms among long-term survivors of OPC. Read More

Biomed Res Int 2020 21;2020:4809125. Epub 2020 Nov 21.

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

Methods: Randomized controlled trials on manual acupuncture treatment of DPN were retrieved from the Medline, Web of Science, PubMed, Cochrane Library, EMBASE, CNKI, WanFang, and VIP databases. Extracted research data were summarized in the tables, and methodological assessment was performed using the risk-of-bias assessment tool of Cochrane. Meta-analysis was performed by Revman 5. Read More

Cancer Sci 2021 May 4. Epub 2021 May 4.

Department of Hematology and Oncology, Osaka University Hospital, Osaka, Japan.

Polatuzumab vedotin (pola) is a CD79b-targeted antibody-drug conjugate delivering a potent anti-mitotic agent (monomethyl auristatin E) to B-cells. This was an open-label, single-arm study of pola 1.8 mg/kg, bendamustine 90 mg/m , rituximab 375 mg/m (pola+BR) Q3W for up to six cycles in patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) who received ≥1 prior line of therapy and were ineligible for autologous stem cell transplantation (ASCT) or experienced treatment failure with prior ASCT. Read More

OTA Int 2020 Sep 27;3(3):e080. Epub 2020 Jul 27.

MetroHealth Medical Center, affiliated with Case Western Reserve University, Cleveland, Ohio.

Objectives: To identify predictors of functional outcomes following treatment of ankle fracture in patients 55 years or older.

Setting: Level 1 Trauma Center.

Patients/participants: Four hundred twenty-nine patients with torsional ankle fractures (44A-C): 233 patients (54%) were ages 55 to 64, 25% were between the ages 65 and 74; 21% were 75 years or older. Read More

J Formos Med Assoc 2021 Apr 29. Epub 2021 Apr 29.

Department of Medical Rehabilitation, "Carol Davila" University of Medicine and Pharmacy, 041914, Bucharest, Romania; Neuromuscular Department, Clinical Emergency Hospital "Bagdasar Arseni", 041914, Bucharest, Romania.

Ten patients suffering from residual symptoms after the resolution of COVID-19, which manifested as fatigue in the lower limbs, have been submitted to nerve conduction studies. Motor demyelinating neuropathy features mainly of the tibial nerves but also the peroneal, median, and ulnar nerves were objectified. These findings might be considered as new neurological characteristics of SARS-CoV-2 infection. Read More

Eur J Haematol 2021 May 2. Epub 2021 May 2.

Hematology Depatment, Catalan Institute of Oncology, Germans Trias i Pujol Hospital and Josep Carreras Research Institute. Badalona, Barcelona, Spain.

Background: Bortezomib-related peripheral neuropathy (PN) affects a relevant proportion of multiple myeloma (MM) patients treated with melphalan, prednisone and bortezomib (VMP). Empirical dose modifications have attempted to reduce toxicity without compromising efficacy.

Patients And Methods: We retrospectively evaluated the dose-response and dose-toxicity relationships in 114 unselected untreated MM patients intended for treatment with VMP with subcutaneous bortezomib. Read More

Ann Phys Rehabil Med 2021 Apr 29:101537. Epub 2021 Apr 29.

German Center for Vertigo and Balance Disorders (DSGZ), Ludwig-Maximilians University of Munich, Marchioninistraße 15, 81377 Munich, Germany; Schoen Clinic Bad Aibling, Kolbermoorer Straße 72, 83043 Bad Aibling, Germany.

Background: Retropulsion is an impairment of body orientation against gravity in the sagittal plane. In a Delphi study, the Scale for Retropulsion (SRP) was developed with a high level of expert agreement.

Objective: To assess the clinimetric properties of the German SRP in patients with neurological disorders. Read More

Ann Oncol 2021 Apr 28. Epub 2021 Apr 28.

GBG and Centre for Haematology and Oncology Bethanien, Frankfurt, Germany.

Background: In the KATHERINE study (NCT01772472), patients with residual invasive early breast cancer (EBC) after neoadjuvant chemotherapy (NACT) plus HER2-targeted therapy had a 50% reduction in risk of recurrence or death with adjuvant T-DM1 versus trastuzumab. Here, we present additional exploratory safety and efficacy analyses.

Patients And Methods: KATHERINE enrolled HER2-positive EBC patients with residual invasive disease in the breast/axilla at surgery after NACT containing a taxane (±anthracycline, ±platinum) and trastuzumab (±pertuzumab). Read More

J Neurosurg 2021 Apr 30:1-9. Epub 2021 Apr 30.

1Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia.

Objective: Early surgical intervention for patients with pituitary apoplexy (PA) is thought to improve visual outcomes and decrease mortality. However, some patients may have good clinical outcomes without surgery. The authors sought to compare the radiological and clinical outcomes of patients with PA who were managed conservatively versus those who underwent early surgery. Read More

J Clin Med 2021 Apr 23;10(9). Epub 2021 Apr 23.

Department of Health Sciences, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.

The combination of nab-paclitaxel and gemcitabine demonstrated greater efficacy than gemcitabine alone but resulted in higher rates of chemotherapy-induced peripheral neuropathy (CINP) in patients with metastatic pancreatic cancer (mPC). We aimed to evaluate the correlation between the development of treatment-related peripheral neuropathy and the efficacy of nab-P/Gem combination in these patients. mPC patients treated with nab-paclitaxel 125 mg/m and gemcitabine 1000 mg/m as a first-line therapy were included. Read More

J Thorac Oncol 2021 Apr 26. Epub 2021 Apr 26.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:

Introduction: We aimed to assess the efficacy and safety of nanoparticle albumin-bound (nab-) paclitaxel for previously treated patients with advanced non-small cell lung cancer (NSCLC).

Methods: In this randomized, open-label, noninferiority phase 3 trial, we enrolled patients with advanced NSCLC previously treated with cytotoxic chemotherapy. Patients were randomly allocated (1:1) to receive docetaxel (60 mg/m) on day 1 or nab-paclitaxel (100 mg/m) on days 1, 8, and 15 of a 21-day cycle. Read More

Agri 2021 Apr;33(2):96-102

Department of Neurology, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, İstanbul, Turkey.

Objectives: Carpal tunnel syndrome (CTS) is the most seen entrapment neuropathy. CTS is a complex syndrome arisen with entrapment of median nerve at wrist. Pain worst at night, paresthesia, hypoesthesia, paralysis, and muscle atrophy can be seen through nerve entrapment level. Read More

Ann Indian Acad Neurol 2021 Jan-Feb;24(1):32-39. Epub 2021 Feb 9.

Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Paraneoplastic Neurological Syndromes (PNSs) are a heterogeneous group of immune-mediated disorders that often precede tumor diagnosis. There are few systematic studies on the spectrum and follow-up of PNSs.

Objective: To analyze the clinical spectrum, associated tumors, antibody profile, outcomes, and prognostic predictors in a cohort of PNSs admitted in a tertiary care center. Read More

BMJ Case Rep 2021 Apr 28;14(4). Epub 2021 Apr 28.

Department of Plastic Surgery, Galway University Hospitals, Galway, Ireland.

This report describes a novel technique of steroid infiltration of the wrist to treat symptomatic carpal tunnel syndrome. Our approach potentially reduces direct trauma to the median nerve when compared with current conventional techniques. The use of a cannula allows infiltration directly into the carpal tunnel and advancement of the blunt tip minimises the risk of sharp trauma to the median nerve and adjacent tendons. Read More

J Clin Oncol 2021 Apr 28:JCO2100108. Epub 2021 Apr 28.

Memorial Sloan Kettering Cancer Center, New York, NY.

Purpose: To improve curability and limit long-term adverse effects for newly diagnosed early-stage (ES), unfavorable-risk Hodgkin lymphoma.

Methods: In this multicenter study with four sequential cohorts, patients received four cycles of brentuximab vedotin (BV) and doxorubicin, vinblastine, and dacarbazine (AVD). If positron emission tomography (PET)-4-negative, patients received 30-Gy involved-site radiotherapy in cohort 1, 20-Gy involved-site radiotherapy in cohort 2, 30-Gy consolidation-volume radiotherapy in cohort 3, and no radiotherapy in cohort 4. Read More

Int J Occup Med Environ Health 2021 Apr 23. Epub 2021 Apr 23.

Hospital South West Jutland, Esbjerg, Denmark (Department of Occupational Medicine).

Objectives: The character of upper limb disorders in computer operators is subject to debate. While nerve involvement is suggested by the presence of pain, paresthesia and subjective weakness, these symptoms are mainly interpreted as related to pathologies outside the nervous system. Findings in a previous study involving computer operators indicated peripheral nerve afflictions with specific locations in symptomatic subjects. Read More

Acta Oncol 2021 Apr 27:1-10. Epub 2021 Apr 27.

Department of Oncology, Oslo University Hospital, Oslo, Norway.

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect of Hodgkin's lymphoma (HL) treatment. We aimed to describe the prevalence of CIPN associated symptoms in long-term HL survivors compared to controls, and determine associated factors, including impact on health-related quality of life (HRQoL).

Material And Methods: A questionnaire, including EORTC QLQ-CIPN-20 for CIPN related symptoms and SF-36 for HRQoL, was completed by 303 HL survivors at a median of 16 years after diagnosis. Read More

Acta Neurol Belg 2021 Apr 27. Epub 2021 Apr 27.

Neurology Department, Coimbra University Hospital Centre, Praceta Mota Pinto, 3000-075, Coimbra, Portugal.

Nervous system (NS) affection may occur in Eosinophilic Granulomatosis with Polyangiitis (EGPA), but its clinical manifestations and pathophysiology are rarely described. Our aims are to characterize central and peripheral NS (CNS/PNS) involvement and compare biological markers in EGPA patients with and without neurological manifestations. Retrospective observational study, including EGPA patients with and without neurological manifestations. Read More

Cutan Ocul Toxicol 2021 Apr 26:1-5. Epub 2021 Apr 26.

Department of Dermatology, Adiyaman University Faculty of Medicine, Adiyaman, Turkey.

Chronic spontaneous urticaria (CSU) is characterised by itchy, red and raised lesions that appear as an attack without any cause and last for six weeks or longer. Omalizumab is a humanised monoclonal antibody that selectively binds to the Ce3 moiety of circulating IgE and is indicated for the treatment of resistant CSU. In this study, we aimed to investigate whether there was peripheral nervous system involvement in patients with chronic urticaria receiving omalizumab treatment. Read More

Acta Neurol Scand 2021 Apr 26. Epub 2021 Apr 26.

Karnataka Medical Research Foundation, Bangalore, India.

Objectives: Median nerve enlargement in leprosy seems to be more proximal than in carpal tunnel syndrome (CTS), but this feature has not been studied systematically. The aim of the study was to compare the sites of median nerve enlargement in patients with leprosy with that of patients with CTS.

Materials And Methods: Transverse sections of the median nerve were recorded from wrist to the mid-forearm (at distal wrist crease and at 2-cm: M1, 4-cm: M2, 6-cm: M3, 8-cm: M4 and 10-cm: M5, proximal to the distal wrist crease in the forearm) in patients with leprosy, CTS and healthy subjects using high-resolution ultrasound. Read More

Neurol Sci 2021 Apr 26. Epub 2021 Apr 26.

Department of Neuroscience, Reproductive and Odontostomatological Science, University of Naples "Federico II", Via Sergio Pansini, 5, 80131, Naples, Italy.

Introduction: In Charcot-Marie-Tooth type 1A (CMT1A) patients, daily life is mainly influenced by mobility and ambulation dysfunctions. The aim of our work was to evaluate the perception of disturbances that mostly impact on daily life in CMT1A patients and its difference on the basis of age, gender, disability, and quality of life.

Methods: Forty-one CMT1A patients underwent neurological assessment focused on establishing clinical disability through the Charcot-Marie-Tooth Neuropathy Score (CMTNS) and quality of life through the Short Form-36 (SF-36) questionnaire. Read More

Auris Nasus Larynx 2021 Apr 22. Epub 2021 Apr 22.

Department of Otorhinolaryngology-Head and Neck Surgery, National University Malaysia Medical Center, Jalan Yaacob Latif, Bandar Tun Razak, Batu 9 Cheras, Kuala Lumpur 56000, Malaysia. Electronic address:

Objective: Laryngeal electromyography (LEMG) is used to confirm neuropathy; traditionally, it is evaluated qualitatively. This study aimed to develop normative values for the thyroarytenoid-lateral cricoarytenoid (TA-LCA) muscle complex by determining the mean turns (MT) and mean amplitudes (MA) using the opposite normal mobile vocal fold in unilateral vocal fold paralysis (VFP). This study also compared the MT and MA of the paralyzed vocal fold with that of the normal side and analyzed their correlations. Read More

Breast Cancer Res Treat 2021 Apr 25. Epub 2021 Apr 25.

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No.17, Panjiayuan Nanli, Chaoyang District, Beijing, 100021, People's Republic of China.

Purpose: We conducted a single-arm prospective phase II trial to evaluate the efficacy and safety of oral metronomic vinorelbine combined with trastuzumab (mNH) in human epidermal growth factor receptor 2-positive (HER2-positive) metastatic breast cancer (MBC) patients.

Methods: HER2-positive MBC patients received oral vinorelbine 40 mg thrice a week and trastuzumab (loading dose of 8 mg/kg, followed by 6 mg/kg every 3 weeks) until disease progression, unacceptable toxicity, or consent withdrawal. The primary endpoints were objective response rate (ORR), clinical benefit rate (CBR; CR + PR + SD for ≥ 24 weeks). Read More

Arq Neuropsiquiatr 2021 Mar;79(3):195-200

Gaziosmanpaşa Taksim Education and Research Hospital, Department of Neurology, Istanbul, Turkey.

Background: Ulnar neuropathy at the elbow (UNE) is the second most common entrapment neuropathy. There is little information about the application of F-wave studies for evaluation of UNE.

Objective: The aim of this study was to evaluate the diagnostic value of minimum F-wave (F-min) latency alterations by comparing this with nerve conduction analyses in UNE-suspected patients. Read More

Diabetologia 2021 Apr 22. Epub 2021 Apr 22.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Republic of Singapore.

Aims/hypothesis: Diabetes progression and complication risk are different in Asian people compared with those of European ancestry. In this study, we sought to understand the epidemiology of diabetes-related lower extremity complications (DRLECs: symptomatic peripheral arterial disease, ulceration, infection, gangrene) and amputations in a multi-ethnic Asian population.

Methods: This was a retrospective observational study using data obtained from one of three integrated public healthcare clusters in Singapore. Read More

Minerva Endocrinol (Torino) 2021 Apr 21. Epub 2021 Apr 21.

Department of Medicine, University of Szeged, Szeged, Hungary.

Dysfunction of the nervous system is well-known in diabetes and also among patients with prediabetes, obesity and hypertension. However, there is only a limited amount of data available on the changes in neuronal function in polycystic ovary syndrome (PCOs), despite the fact that this condition is also accompanied by metabolic and vascular abnormalities. The aim of our study was to assess the cardiovascular autonomic and peripheral sensory function in patients with PCOs. Read More

J Clin Invest 2021 Apr 20. Epub 2021 Apr 20.

Genetic Resource Science, The Jackson Laboratory, Bar Harbor, United States of America.

Charcot-Marie-Tooth disease type 4J (CMT4J) is caused by recessive, loss-of-function mutations in FIG4, encoding a phosphoinositol(3,5)P2-phosphatase. CMT4J patients have both neuron loss and demyelination in the peripheral nervous system, with vacuolization indicative of endosome/lysosome trafficking defects. Although the disease is highly variable, the onset is often in childhood and FIG4 mutations can dramatically shorten lifespan. Read More