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Neurologia (Engl Ed) 2022 May 24;37(4):243-249. Epub 2021 Apr 24.

Servicio de Neurofisiología Clínica, Complejo Hospitalario de Navarra, Pamplona, Spain.

Introduction: Hereditary neuropathy with liability to pressure palsy (HNPP) is an autosomal dominant disorder, typically presenting with recurrent episodes of mononeuropathy in nerves susceptible to compression, with similar neurophysiological characteristics. However, other clinical and neurophysiological presentations have been reported.

Methods: We retrospectively analysed the clinical and neurophysiological characteristics of 20 patients with genetically confirmed HNPP. Read More

J Immunother Cancer 2022 May;10(5)

Pediatrics, New York Medical College, Valhalla, New York, USA

Background: Cure rates for Hodgkin's lymphoma are excellent, but excess short-term and long-term morbidities from treatment remain a concern. Immunotherapy targeting both tumor antigens and the immunosuppressive tumor microenvironment in children, adolescents, and young adults with Hodgkin's lymphoma may improve early response rates and eliminate toxic chemotherapy and radiation, thus minimizing toxicity. We conducted a phase II study to evaluate the safety and overall response rate of brentuximab vedotin and rituximab in combination with risk-adapted chemotherapy in children, adolescents, and young adults with newly diagnosed classic Hodgkin's lymphoma (cHL). Read More

J Neurol 2022 May 18. Epub 2022 May 18.

Department of Neurology, Emory University School of Medicine, 12 Executive Park Drive NE, Atlanta, GA, 30329, USA.

Background: Facial nerve palsy is a cardinal manifestation of neurosarcoidosis, but dedicated studies of this disease feature have not been conducted. We sought to clarify the impact of facial palsy on the diagnosis of neurosarcoidosis, its subsequent clinicoradiographic evolution, and eventual treatment decisions.

Methods: A single-center retrospective analysis of patients with neurosarcoidosis and facial palsy was conducted over the preceding 10 years (01/01/2011-08/12/2021). Read More

Osteoporos Int 2022 May 18. Epub 2022 May 18.

Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The widely recommended fracture prediction tool FRAX was developed based on and for the general population. Although several adjusted FRAX methods were suggested for type 2 diabetes (T2DM), they still need to be evaluated in T2DM cohort.

Introduction: This study was undertaken to develop a prediction model for Chinese diabetes fracture risk (CDFR) and compare its performance with those of FRAX. Read More

Muscle Nerve 2022 May 17. Epub 2022 May 17.

Department of Neurology, Nagoya University Graduate School of Medicine, Japan.

Introduction/aims: The mechanism of complement-mediated neurological injury in vasculitic neuropathy associated with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) is unknown. The current study aimed to investigate the local activation of the complement system in vasculitic neuropathy associated with SLE and RA.

Methods: We analysed sural nerve biopsy specimens collected from patients with SLE (n = 12) and RA (n = 12). Read More

BMJ Case Rep 2022 May 17;15(5). Epub 2022 May 17.

Neurology, CARE Hospital, Banjara Hills, Hyderabad, India.

J Ayub Med Coll Abbottabad 2022 Apr-Jun;34(2):295-299

Department of Radiology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan.

Background: Carpal tunnel syndrome (CTS) is the most common nerve entrapment neuropathy caused by compression of median nerve at wrist as it passes through Osseo fibrous canal known as carpal tunnel. Epidemiological statistics shows one in every ten people develops the disease at any stage of life. CTS mostly affect females than males with mean age of 50. Read More

Int Ophthalmol 2022 May 13. Epub 2022 May 13.

Department of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, 34098, Fatih, Istanbul, Turkey.

Background: Optic atrophy is an end-stage pathology of optic nerve diseases that is characterized by optic nerve pallor and vision loss. Because of its sight-threatening effects, understanding its epidemiology and etiology is crucial. In this study, we aimed to determine the epidemiologic features of optic nerve pathologies which lead to optic atrophy. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr;47(4):497-504

Department of Hematology, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Objectives: There is less clinical data on multiple myeloma (MM) in China, and the aim of this study was to collect and analyze the clinical data of newly diagnosed multiple myeloma (NDMM) patients in Hunan Province during 1 year, to understand the real clinical features and treatment outcome for Hunan Province patients with MM, and to strengthen the understanding of the standardized diagnosis process and treatment plan of MM.

Methods: The clinical data of 529 patients with NDMM in 12 large-scale general hospitals in Hunan Province from January 1 to December 31, 2019 were collected and analyzed, including baseline data, treatment regimens, duration of treatment, and adverse reactions. The clinical characteristics, treatment, and safety of patients were analyzed by SPSS 21. Read More

J Foot Ankle Surg 2022 Apr 10. Epub 2022 Apr 10.

Massachusetts General Hospital and Newton-Wellesley Hospital, Harvard Medical School, Boston, MA; Newton-Wellesley Hospital, Newton, MA.

While adjacent joint arthritis is a recognized long-term downside of primary tibiotalar arthrodesis (TTA), few studies have identified risk factors for early subtalar arthrodesis (STA) after TTA. This study aims to identify the risk factors for STA within the first few years following TTA. All patients older than 18 years undergoing TTA between 2008 and 2016 were identified retrospectively. Read More

J Hand Surg Am 2022 May 6. Epub 2022 May 6.

Department of Orthopedics and Traumatology, Basaksehir Pine and Sakura City Hospital, Istanbul, Turkey. Electronic address:

Purpose: Earlier research has explored carpal tunnel release (CTR) surgery outcomes using electrodiagnostic tests (EDX). However, evaluation of the median nerve before and after CTR by ultrasound (US) is understudied. This study aimed to establish the outcomes of CTR by EDX and US, and examine the correlation between the clinical improvement and US after CTR. Read More

Neurol India 2022 Mar-Apr;70(2):491-503

Division of Hand Surgery, Cajuru University Hospital, Curitiba, Brazil Cajuru University Hospital, Curitiba, Brazil.

Background: Carpal tunnel syndrome (CTS) is the most common peripheral nerve entrapment. One of the most devastating complications is complex regional pain syndrome.

Objectivities: The aim of this study was to systematically analyze available evidence about complex regional pain syndrome after carpal tunnel syndrome surgery (CTSS), its risks, associated factors, and treatments. Read More

J Int Med Res 2022 May;50(5):3000605221097376

Department of Orthopaedics, Taizhou People's Hospital, Taizhou, Jiangsu Province, China.

This current report presents a rare case of carpal tunnel syndrome with chronic bursitis that was treated successfully by open surgery. A 53-year-old female patient that had begun to experience swelling, pain and limited flexion activity of the left wrist 1 year previously presented because of a deterioration in her condition and numbness of the thumb, index finger and middle finger in the previous 2 months without any treatment. The diagnosis of bursitis should be based on clinical symptoms and signs, combined with colour ultrasonography, magnetic resonance imaging, arthroscopy and arthrography. Read More

Cureus 2022 Apr 7;14(4):e23928. Epub 2022 Apr 7.

Radiosurgery, International Cancer Center, Diagnostic Hospital, San Salvador, SLV.

Introduction The complex anatomy of the cavernous sinus confers a true challenge when it comes to safe tumor resection. Due to its non-invasive nature, stereotactic radiosurgery (SRS) is expected to have lower mortality and morbidity rates than microsurgery. The purpose of this study was to evaluate clinical results regarding visual symptoms after SRS for benign tumors invading the cavernous sinus. Read More

J Clin Oncol 2022 May 5:JCO2102628. Epub 2022 May 5.

Tokai University School of Medicine, Isehara, Japan.

Purpose: The phase III ACHIEVE trial conducted in Japan was one of six prospective studies included in the International Duration Evaluation of Adjuvant Therapy collaboration, which explored whether 3 months of adjuvant fluorouracil, leucovorin, and oxaliplatin (FOLFOX) or capecitabine and oxaliplatin (CAPOX) therapy would be noninferior to 6 months of treatment in patients with curatively resected stage III colon cancer. We report the final analyses of survival and long-term safety.

Patients And Methods: Eligible patients were randomly assigned (1:1) to either 3 or 6 months of adjuvant chemotherapy (modified [m]FOLFOX6 or CAPOX, as selected by the treating physician). Read More

Blood 2022 May;139(18):2747-2757

Hôpital Notre Dame de Bon Secours, Metz-Thionville, France.

High-dose melphalan (HDM) and transplantation are recommended for eligible patients with multiple myeloma. No other conditioning regimen has proven to be more effective and/or safer. We previously reported in a phase 2 study that bortezomib can safely and effectively be combined with HDM (Bor-HDM), with a 32% complete response (CR) rate after transplantation. Read More

J Neurol 2022 May 3. Epub 2022 May 3.

Department of Neurology, DMU Médecine, AP-HP, Henri Mondor University Hospital, 94010, Creteil, France.

Introduction: A significant number of patients with a peripheral neuropathy have IgM monoclonal gammopathy (IgM-MG). In this work, we encompassed the spectrum and outcome of IgM-related neuropathies (IgM-NP) in a large monocentric cohort of patients with IgM-MG.

Methods: We retrospectively reviewed the neurological and hematological findings and the course of neuropathy in all patients with IgM-MG over a five-year period in our center (Henri Mondor hospital, Assistance Publique Hôpitaux de Paris (APHP), France). Read More

Eur J Haematol 2022 May 3. Epub 2022 May 3.

First Department of Medicine, Charles University and General University Hospital, Prague, Czech Republic.

Objectives: Polatuzumab vedotin with bendamustine and rituximab (Pola-BR) was approved for treatment of transplant-ineligible patients with relapsed/refractory DLBCL (R/R DLBCL). However, the number of patients treated in the GO29365 trial including the extension cohort was limited, and more data evaluating the efficacy of this treatment regimen is needed.

Methods: We analyzed 21 patients with R/R DLBCL to determine real-life efficacy and safety of Pola-BR regimen. Read More

Brain Behav 2022 May 2:e32546. Epub 2022 May 2.

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

Background: To investigate the association between disease duration and the severity of bilateral vestibulopathy in individuals with complete or incomplete CANVAS (Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome) and biallelic RFC1 repeat expansions.

Methods: Retrospective analysis of clinical data and the vestibulo-ocular reflex quantified by the video head impulse test in 20 patients with confirmed biallelic RFC1 repeat expansions.

Results: Vestibulo-ocular reflex gain at first admittance 6. Read More

Front Endocrinol (Lausanne) 2022 14;13:831793. Epub 2022 Apr 14.

Complications Research, Steno Diabetes Center Copenhagen, Herlev, Denmark.

Introduction: Diabetic cardiovascular autonomic neuropathy (CAN) is associated with increased mortality and morbidity. To explore metabolic mechanisms associated with CAN we investigated associations between serum metabolites and CAN in persons with type 1 diabetes (T1D).

Materials And Methods: Cardiovascular reflex tests (CARTs) (heart rate response to: deep breathing; lying-to-standing test; and the Valsalva maneuver) were used to diagnose CAN in 302 persons with T1D. Read More

Evid Based Complement Alternat Med 2022 21;2022:2661649. Epub 2022 Apr 21.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Background: Diabetes sensorimotor polyneuropathy (DSPN) is a common complication of diabetes. Diet has been previously related to DSPN. However, no studies have investigated the relationship between the inflammatory potential of the whole diet and DSPN. Read More

Clin Neurophysiol 2022 Apr 9;139:1-8. Epub 2022 Apr 9.

Department of Orthopedic Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. Electronic address:

Objective: To measure the neuromagnetic fields of carpal tunnel syndrome patients after electrical digital nerve stimulation and evaluate median nerve function with high spatial resolution.

Methods: A superconducting quantum interference device magnetometer system was used to record neuromagnetic fields at the carpal tunnel after electrical stimulation of the middle digital nerve in 10 hands of nine patients with carpal tunnel syndrome. The patients were diagnosed based on symptoms (numbness, tingling, and pain) supported by a positive Phalen or Tinel sign. Read More

Zhonghua Nei Ke Za Zhi 2022 May;61(5):531-536

Department of Hematology, Peking University People's Hospital & Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing 100044, China Collaborative Innovation Center of Hematology, Suzhou 215006, China.

To investigate the efficacy and safety of lenalidomide combined with bortezomib and dexamethasone (RVD) in patients with newly diagnosed multiple myeloma (NDMM). A total of 100 consecutive NDMM patients treated with RVD from August 2016 to September 2020 at Peking University People's Hospital were retrospectively analyzed, including response, drug toxicity, follow-up and survival, and subgroup analysis. The median follow-up time was 19. Read More

Am J Med 2022 Apr 25. Epub 2022 Apr 25.

Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address:

Background: Epidemiological data on the associations of microvascular disease with atrial fibrillation are scarce. We evaluated the associations of diabetes-related microvascular disease in multiple vascular beds and its burden with incident atrial fibrillation among adults with type 2 diabetes.

Methods: A total of 7,603 participants with type 2 diabetes and without atrial fibrillation were assessed for diabetic kidney disease, retinopathy or neuropathy at baseline in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study. Read More

Int Ophthalmol 2022 Apr 27. Epub 2022 Apr 27.

Prevention of Cardiovascular Disease Research Center, Imam Hussein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To assess the occurrence and severity of electrodiagnostic signs of carpal tunnel syndrome (ED-CTS) in patients with ocular pseudoexfoliation (PEX) and compare them with normal subjects.

Method: A cross-sectional study with comparison group was designed and 60 patients with PEX were recruited from May 2019 to February 2021, and the findings were compared with 59 healthy subjects. All patients underwent complete ophthalmologic examination and nerve conduction velocity test at the median nerve was used to assess the occurrence and severity of ED-CTS in both hands. Read More

Neurol Sci 2022 Apr 25. Epub 2022 Apr 25.

Sarah Network of Rehabilitation Hospitals - Rio de Janeiro Unit, Rio de Janeiro, Brazil.

Objective: The objective of this study is to describe the first series of spinocerebellar ataxia (SCA) in Rio de Janeiro, whose population has a high proportion of mixed Portuguese and African ancestry.

Methods: We reviewed the medical records of patients with progressive ataxia evaluated at the Sarah Network of Rehabilitation Hospitals (Rio de Janeiro). Clinical course, genetic tests for hereditary ataxia, brain MRI, and electroneuromyography were analyzed. Read More

Diabet Med 2022 Apr 25:e14857. Epub 2022 Apr 25.

Department of Medicine, Division of Endocrinology, Diabetes & Metabolism, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Aim: We evaluated the associations of heart rate variability (HRV) with incident vision-threatening retinopathy and retinopathy progression among adults with type 2 diabetes.

Methods: Participants recruited to the ACCORD (Action to Control Cardiovascular Risk in Diabetes) study with HRV measures at baseline were analysed. HRV measures included standard deviation of all normal-to-normal intervals (SDNN) and root mean square of successive differences between normal-to-normal intervals (rMSSD). Read More

Pan Afr Med J 2022 10;41:116. Epub 2022 Feb 10.

Department of Plastic Surgery, Faculty of Medicine of Tunis, University El Manar Tunis, La Rabta, Tunis, Tunisia.

Carpal tunnel syndrome is the most common peripheral neuropathy in adults but remains a very rare condition in children. Lysosomal overload diseases (mucopolysaccharidosis and mucolipidosis), anatomical abnormalities, trauma and familial forms are the most frequent aetiologies. No studies report idiopathic forms. Read More

Diabetol Int 2022 Apr 1;13(2):436-446. Epub 2021 Nov 1.

Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495 Japan.

Introduction: In Japan, epidemiological studies on type 1 diabetes (T1D) have mainly focused on the disease in childhood. Meanwhile, limited information is available regarding the clinical features of adolescent and adult T1D. Therefore, we aimed to investigate their current clinical state in Saitama prefecture near Tokyo, Japan. Read More

Eur J Neurol 2022 Apr 23. Epub 2022 Apr 23.

Univ. Lille, Inserm, CHU Lille. Lille Neuroscience & Cognition, Degenerative and vascular cognitive disorders, F-59000, Lille, France.

Background: Although several case series have described nitrous oxide-associated neurological disorders, a comprehensive assessment of exposure characteristics (e.g., time to onset, level of exposure) in substance abusers has not been performed. Read More