Search Our Scientific Publications & Authors

Clin Auton Res 2019 Feb 19. Epub 2019 Feb 19.

Department of Radiology, New York University School of Medicine, New York, NY, 10016, USA.

Purpose: Familial dysautonomia (FD) is a rare autosomal recessive disease that affects the development of sensory and autonomic neurons, including those in the cranial nerves. We aimed to determine whether conventional brain magnetic resonance imaging (MRI) could detect morphologic changes in the trigeminal nerves of these patients.

Methods: Cross-sectional analysis of brain MRI of patients with genetically confirmed FD and age- and sex-matched controls. Read More

Orphanet J Rare Dis 2019 Feb 18;14(1):46. Epub 2019 Feb 18.

Program for the Study of Neurodevelopment in Rare Disorders and Center for Rare Disease Therapy, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA, 15144, USA.

Background: Krabbe disease is a rare neurological disorder caused by a deficiency in the lysosomal enzyme, β-galactocerebrosidase, resulting in demyelination of the central and peripheral nervous systems. If left without treatment, Krabbe disease results in progressive neurodegeneration with reduced quality of life and early death. The purpose of this prospective study was to describe the natural progression of early onset Krabbe disease in a large cohort of patients. Read More

Radiother Oncol 2019 Feb 31;131:112-119. Epub 2018 Dec 31.

Massachusetts General Hospital, Boston, USA. Electronic address:

Introduction: Radiation-induced optic neuropathy (RION) is a complication of radiation therapy (RT) that causes blindness. We aimed to define the tolerance of the anterior optic pathway to fractionated RT and identify risk factors for RION.

Materials/methods: Patients with chordoma or chondrosarcoma of the skull base treated with proton and photon therapy between 1983 and 2013, who received a minimum of 30 Gy (relative biologic effectiveness [RBE]) to the anterior optic pathway were assessed. Read More

J Neurosurg 2019 Feb 15:1-8. Epub 2019 Feb 15.

1Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah; and.

OBJECTIVECavernous sinus meningiomas are complex tumors that offer a perpetual challenge to skull base surgeons. The senior author has employed a management strategy for these lesions aimed at maximizing tumor control while minimizing neurological morbidity. This approach emphasizes combining "safe" tumor resection and direct decompression of the roof and lateral wall of the cavernous sinus as well as the optic nerve. Read More

Sci Rep 2019 Feb 14;9(1):2027. Epub 2019 Feb 14.

Department of Radiology, Aichi Medical University Hospital, Aichi, Japan.

To identify predictive factors of prognosis after radiotherapy with concurrent steroid pulse therapy for thyroid eye disease, retrospective analyses were performed among 77 patients. Clinical activity score and magnetic resonance imaging were used to evaluate degrees of orbital inflammation. As a pre-treatment work-up, the thyroid-stimulating antibody (TSAb) level was measured. Read More

Gan To Kagaku Ryoho 2019 Jan;46(1):187-189

Dept. of Surgery, Osaka Police Hospital.

We conducted a retrospective comparative study on feasibility of S-1/oxaliplatin(SOX)therapy and S-1/cisplatin therapy with short hydration(SP-SH)for gastric cancer in the outpatient setting. The subjects were patients with gastric cancer aged younger than 75 years who underwent SOX or SP-SH therapy at our hospital. There were 22 patients in the SOX group and 30 patients in the SP-SH group. Read More

BMC Cancer 2019 Feb 14;19(1):150. Epub 2019 Feb 14.

Department of Oncology, Cumming School of Medicine, University of Calgary, Tom Baker Cancer Centre, 1331 29 St NW, Calgary, Alberta, T2N 4N2, Canada.

Background: Cognitive impairment is commonly reported in patients receiving chemotherapy, but the acuity of onset is not known. This study utilized the psychomotor vigilance test (PVT) and trail-making test B (TMT-B) to assess cognitive impairment immediately post-chemotherapy.

Methods: Patients aged 18-80 years receiving first-line intravenous chemotherapy for any stage of breast or colorectal cancer were eligible. Read More

Neurology 2019 Feb 13. Epub 2019 Feb 13.

From the Department of Neurology (P.S.N.), National Neuroscience Institute, Singapore; Department of Neurology (P.S.N., P.J.D., R.S.L., M.V.P., P.J.B.D.), and Division of Biomedical Statistics and Informatics (P.T.), Mayo Clinic, Rochester, MN.

Objective: To determine the previously unknown incidence of lumbosacral-radiculoplexus neuropathy (LRPN) and its association with diabetes mellitus (DM).

Methods: LRPN defined by clinical and electrophysiologic criteria was identified among Olmsted County, Minnesota, residents during a 16-year period (2000-2015) using the unique facilities of the Rochester Epidemiology Project. DM was ascertained using American Diabetes Association criteria. Read More

Pol Arch Intern Med 2019 Feb 13. Epub 2019 Feb 13.

INTRODUCTION It is widely believed that patients with diabetes are at increased risk of severe and premature coronary artery disease (CAD) when compared to non-diabetic individuals. OBJECTIVES To evaluate the prevalence, 7-year incidence, predictors, and outcomes of obstructive and non-obstructive CAD in patients with long-lasting type 1 diabetes. PATIENTS AND METHODS We enrolled 2330 patients at a median age of 50 years with a median diabetes duration of 32 years. Read More

J Peripher Nerv Syst 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurology, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.

Objective: To evaluate the long-term outcome in Danish patients treated for multifocal motor neuropathy (MMN).

Methods: A population-based, cross-sectional study of patients referred to the Danish hospital system between 1985 and 2006.

Results: Thirty-four MMN patients were identified, three had died of unrelated diseases, 10 were excluded, one did not reply to study request and 20 were included. Read More

Br J Cancer 2019 Feb 12. Epub 2019 Feb 12.

Pharmaceuticals Group, Nippon Kayaku Co., Ltd., Tokyo, Japan.

Background: NK105 is a novel nanoparticle drug delivery formulation that encapsulates paclitaxel (PTX) in polymeric micelles. We conducted an open-label phase III non-inferiority trial to compare the efficacy and safety of NK105 and PTX in metastatic or recurrent breast cancer.

Methods: Patients were randomly assigned in a 1:1 ratio to receive either NK105 (65 mg/m) or PTX (80 mg/m) on days 1, 8 and 15 of a 28-day cycle. Read More

J Neurosurg Spine 2019 Feb 8:1-8. Epub 2019 Feb 8.

OBJECTIVEA common cause of peroneal neuropathy is compression near the fibular head. Studies demonstrate excellent outcomes after decompression but include few cases (range 15-60 patients). Consequently, attempts to define predictors of good outcomes are limited. Read More

Clin Breast Cancer 2018 Dec 14. Epub 2018 Dec 14.

Division of Medical Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, WA; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA. Electronic address:

Introduction: Angiogenesis and epidermal growth factor receptor signaling are potential therapeutic targets in triple negative breast cancer (TNBC). We hypothesized that targeting these critical pathways would prolong progression-free survival with first-line therapy for metastatic TNBC.

Patients And Methods: We conducted a phase II trial of nab-paclitaxel and bevacizumab, followed by maintenance therapy with bevacizumab and erlotinib, for patients with metastatic TNBC. Read More

PM R 2019 Feb 7. Epub 2019 Feb 7.

Division of Physical Medicine and Rehabilitation, Department of Medicine, University of Toronto, Toronto.

Background: Carpal tunnel syndrome (CTS) is the most common entrapment mono-neuropathy of the median nerve. In comparison to open surgical and endoscopic carpal tunnel release, a new ultrasound guided hook knife carpal tunnel release (CTR) procedure was reported to have superior results in terms of reduced morbidity and early return to work.

Objective: To evaluate the reproducibility of the hook knife CTR procedure when performed by musculoskeletal ultrasound trained physicians without a prior experience in this technique. Read More

Muscle Nerve 2019 Feb 7. Epub 2019 Feb 7.

Department of Neurology, Otto-von-Guericke University, Leipziger Straße 44, 39120, Magdeburg, Germany.

Introduction: We aimed to identify ALS patients displaying suspected peripheral nervous system (PNS) inflammation, to compare them to those with suspected PNS degeneration.

Methods: We measured sonographic median and ulnar nerve cross-sectional area (CSA) and CSF albumin/serum albumin ratio (Q ) in ALS patients, to classify them as having suspected PNS degeneration (small CSA/low Q ) or inflammation (larger CSA/high Q ).

Results: 57% of patients had suspected PNS degeneration, 21% had suspected PNS inflammation, and 21% displayed suspected "normal PNS state". Read More

Can J Neurol Sci 2019 Feb 6:1-5. Epub 2019 Feb 6.

Department of Neurology,Memorial University of Newfoundland,St. John's, Newfoundland,Canada.

Introduction: Lewis-Sumner syndrome (LSS) is a demyelinating peripheral neuropathy described in 1982.

Methods: We reviewed the charts of nine LSS patients in neurological care for their symptoms, response to different treatment regimens, and pattern of nerve involvement.

Results: One patient had an Adie's pupil. Read More

Int J Oncol 2019 Feb 1. Epub 2019 Feb 1.

Department of Medical Oncology, Franco‑British Institute, 92300 Levallois‑Perret, France.

Aflibercept in combination with 5‑fluorouracil (5‑FU)/irinotecan improves overall survival in the second‑line therapy of patients with metastatic colorectal cancer (mCRC). In this study, we evaluated the effects of aflibercept in first‑line therapy with FOLFOX followed by maintenance with fluoropyrimidine. VELVET was a prospective, single‑arm multicenter phase II study (completed). Read More

Br J Haematol 2019 Feb 3. Epub 2019 Feb 3.

Center for Pharmacoepidemiology and Pharmacoeconomic Research, University of Illinois at Chicago, Chicago, IL, USA.

Conflicting evidence exists on the epidemiology of type 2 diabetes mellitus (T2DM) among patients with sickle cell disease (SCD). This study measured the prevalence, incidence and clinical outcomes associated with T2DM in a large US population of commercially-insured adults aged ≥20 years with SCD between 2009 and 2014. Among 7070 patients with SCD, the mean age (median) was 39 (37) years and 60·8% were female. Read More

Med Clin North Am 2019 Mar;103(2):357-370

Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, WACC 739B, Boston, MA 02114, USA. Electronic address:

Upper extremity entrapment neuropathies are common and can cause pain, sensory loss, and muscle weakness that lead to functional disability. In this article, the authors review common entrapment neuropathies of the upper extremities, including median neuropathy at the wrist (carpal tunnel syndrome), ulnar neuropathy at the elbow, and radial neuropathy. The authors discuss the pathophysiology of nerve compression and typical etiologies, as well as strategies for differentiating between common mimics such as cervical radiculopathy and for selecting between various treatment modalities. Read More

Physiother Res Int 2019 Jan 29:e1770. Epub 2019 Jan 29.

Department of Basic Sciences, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background And Purpose: Cupping therapy has been used widely as a safe and common method to tackle soft tissue lesions in most Asian countries, Central Europe, and parts of the United States. In this study, cupping therapy has been used for the treatment of carpal tunnel syndrome (CTS), which is the most common entrapment neuropathy. The aim of this study was to investigate the effect of cupping therapy on the clinical findings of patients with CTS. Read More

Health Sci Rep 2019 Jan 7;2(1):e104. Epub 2018 Dec 7.

Department of Hematology University Hospital Leuven Leuven Belgium.

Aims: Studies have shown that bortezomib retreatment is effective in relapsed/refractory multiple myeloma (MM). The observational, prospective electronic VELCADE OBservational Study (eVOBS) study assessed bortezomib-based therapies for patients with MM in everyday practice. Here, we report on those patients receiving retreatment with bortezomib. Read More

World J Diabetes 2019 Jan;10(1):47-56

Department of Orthopedics, Obafemi Awolowo University Teaching Hospitals Complex, Osun 220222, Nigeria.

Background: Neuropathy is a common complication of diabetes mellitus resulting from direct damage by hyperglycemia to the nerves and/or ischemia by microvascular injury to the endoneurial vessels which supply the nerves. Median nerve is one of the peripheral nerves commonly affected in diabetic neuropathy. The median nerve size has been studied in non-Nigerian diabetic populations. Read More

PLoS One 2019 29;14(1):e0211354. Epub 2019 Jan 29.

Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Antiretroviral therapy has surely increased the life expectancy of people living with HIV. However, long term complications like HIV associated sensory neuropathy has a negative impact on quality of life among people living with HIV (PLHIV). In Ethiopia, lack of data on magnitude of the burden and predictors of HIV associated sensory neuropathy in many resource limited setting has led to under diagnosis and eventually under management of HIV-SN. Read More

Reumatol Clin 2019 Jan 25. Epub 2019 Jan 25.

Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad de Málaga, Málaga, España.

Background And Objectives: Evidence and specific interventions after carpal tunnel release are limited. The main purpose of this study was to elucidate the current practice patterns of professionals from around the world after carpal tunnel release.

Material And Methods: A 15-item English survey was designed and distributed via email and through social networks to professionals from different countries. Read More

Cancer 2019 Jan 28. Epub 2019 Jan 28.

The Angeles Clinic and Research Institute, Los Angeles, California.

Background: Glembatumumab vedotin is an antibody-drug conjugate that produced preliminary clinical activity against advanced melanoma in a phase 1 dose-escalation trial. The objective of the current study was to investigate further the antitumor activity of glembatumumab vedotin at the recommended phase 2 dose in heavily pretreated patients with melanoma.

Methods: This single-arm, phase 2 study enrolled patients with stage IV melanoma who were refractory to checkpoint inhibition and to B-raf proto-oncogene, serine/threonine kinase (BRAF)/mitogen-activated protein kinase kinase (MEK) inhibition (in the presence of a BRAF valine mutation at codon 600). Read More

Neurol India 2019 Jan-Feb;67(Supplement):S71-S76

Department of Neurology, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India.

Purpose: The purpose of the study was to assess the usefulness of high-resolution ultrasonography (HRU) in the evaluation of diabetic peripheral neuropathy (DPN).

Methods: Thirty-seven adult diabetic patients with clinically diagnosed DPN and 45 healthy adult volunteers were included in the study. HRU of the right medial, ulnar, common peroneal, and posterior tibial nerves was done. Read More

J Orthop Case Rep 2018 Jul-Aug;8(4):57-60

Department of Orthopaedics, Aristotle University of Thessaloniki, George Papanikolaou Hospital, Thessaloniki. Greece.

Introduction: Lipofibromatous hamartoma (LFH) is a very rare, benign, slow-growing peripheral nerve tumor.

Case Report: We present a case of LFH of the median nerve, which caused enlargement of the median nerve and the digital branches in a young male, and was treated surgically. Our treatment choice was resection of large portions of the fibrofatty tissue and decompression of the carpal tunnel. Read More

J Hand Surg Am 2019 Jan 23. Epub 2019 Jan 23.

Department of Orthopaedic Surgery, Nippon Medical School, Tokyo, Japan.

Purpose: To determine clinical outcomes of Preiser disease treated with closing radial wedge osteotomy (CRWO).

Methods: Seven patients with Preiser disease underwent CRWO. Two wrists had stage 2 disease, 3 had stage 3, 2 had stage 4 (Herbert-Lanzetta classification). Read More

J Brachial Plex Peripher Nerve Inj 2019 Jan 22;14(1):e1-e8. Epub 2019 Jan 22.

Department of Plastic Surgery, Shifa International Hospital, Islamabad, Pakistan.

 Carpal tunnel syndrome (CTS) is the most frequently encountered compressive neuropathy of the upper limb. The treatment of CTS ranges from conservative management to carpal tunnel release. Many patients with misconception about the potential morbidity and with the hope of successful conservative treatment delay the surgical release of carpal tunnel. Read More

Hand (N Y) 2019 Jan 24:1558944718822851. Epub 2019 Jan 24.

1 Washington University School of Medicine in St. Louis, MO, USA.

Background: Intrinsic atrophy and debilitating sensory loss are prominent features of severe ulnar neuropathy with limited surgical options to reliably improve recovery. Restoration of sensation is important to provide protection for the vulnerable ulnar border of the hand. Here, we report our experience with side-to-side sensory nerve grafting from the median to ulnar nerve in the palm to enhance ulnar sensory recovery. Read More

J Peripher Nerv Syst 2019 Jan 22. Epub 2019 Jan 22.

CSL Behring, Marburg, Germany, and King of Prussia, Pennsylvania.

Intravenous immunoglobulin (IVIG) is a potential therapy for chronic inflammatory demyelinating polyneuropathy (CIDP). To investigate the efficacy and safety of the IVIG IgPro10 (Privigen) for treatment of CIDP, results from Privigen Impact on Mobility and Autonomy (PRIMA), a prospective, open-label, single-arm study of IVIG in immunoglobulin (Ig)-naïve or IVIG pre-treated subjects (NCT01184846, n = 28) and Polyneuropathy And Treatment with Hizentra (PATH), a double-blind, randomized study including an open-label, single-arm IVIG phase in IVIG pre-treated subjects (NCT01545076, IVIG restabilization phase n = 207) were analyzed separately and together (n = 235). Efficacy assessments included change in adjusted inflammatory neuropathy cause and treatment (INCAT) score, grip strength and Medical Research Council (MRC) sum score. Read More

J Clin Immunol 2019 Jan 22. Epub 2019 Jan 22.

Centre de Référence National des Cytopénies Autoimmunes de l'Enfant (CEREVANCE), University Hospital of Bordeaux, Bordeaux, France.

Purpose: Immune thrombocytopenic purpura (ITP) and autoimmune hemolytic anemia (AIHA) are associated in the definition of Evans syndrome (ES). The occurrence of neurological involvement in this population is poorly described and suggests an underlying primary immunodeficiency (PID). We aimed to describe the clinical manifestations, evolution, and PID profiles of these patients. Read More

J Cachexia Sarcopenia Muscle 2019 Jan 21. Epub 2019 Jan 21.

Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands.

Background: Palliative systemic treatment in patients with advanced or metastatic esophagogastric cancer may result in improved overall survival and quality of life but can also lead to considerable toxicity. In various cancer types, severe muscle mass depletion (sarcopenia) and poor muscle strength are associated with decreased survival and increased chemotherapy-related toxicity. The aim of this study is to determine the impact of body composition on survival and chemotherapy toxicity in esophagogastric cancer patients treated with first-line palliative chemotherapy. Read More

Prostate 2019 Jan 20. Epub 2019 Jan 20.

Progenics Pharmaceuticals, Inc., New York, New York.

Background: Prostate-specific membrane antigen (PSMA) is a well-characterized target that is overexpressed selectively on prostate cancer cells. PSMA antibody-drug conjugate (ADC) is a fully human IgG1 monoclonal antibody conjugated to the microtubule disrupting agent monomethyl auristatin E (MMAE), which is designed to specifically bind PSMA-positive cells, internalize, and then release its cytotoxic payload into the cells. PSMA ADC has demonstrated potent and selective antitumor activity in preclinical models of advanced prostate cancer. Read More

J Ultrasound Med 2019 Jan 17. Epub 2019 Jan 17.

Department of Biostatistics, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.

Objectives: Carpal tunnel syndrome (CTS) is an entrapment neuropathy resulting from compression of the median nerve at the carpal tunnel (CT). We assessed the role of high-resolution ultrasound (US) in monitoring patients with CTS treated with corticosteroid injection.

Methods: We performed high-resolution US evaluations of the wrists of patients with CTS before and after treatment with local corticosteroid. Read More

JCO Clin Cancer Inform 2018 12;2:1-10

All authors: University of Pennsylvania, Philadelphia, PA.

Purpose: Multimodal treatment of Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) yields excellent outcomes; however, survivors are at risk of developing myriad late and long-term effects.

Methods: From a convenience sample of 964 survivors of HL (37%) and NHL (63%) using a publicly available Internet-based survivorship care plan (SCP) tool between 2011 and 2016, we examined patient-reported cancer care, toxicities, and survivorship care data.

Results: Of all survivors, 67% were female and 84% were white and 88% were free of cancer. Read More

J Diabetes Res 2018 10;2018:2309108. Epub 2018 Dec 10.

University Hospital of Würzburg, Department of Neurology, 97080 Würzburg, Germany.

Diabetic peripheral neuropathy (DPN) is a common complication of diabetes with potential severe consequences. Its pathogenesis involves hyperglycemia-linked mechanisms, which may include changes in the expression of neurotrophic growth factors. We analyzed the expression of 29 factors potentially related to nerve degeneration and regeneration in skin biopsies from 13 type 1 diabetic pancreas and kidney recipients with severe DPN including severe depletion of intraepidermal nerve fibers (IENF) in lower limb skin biopsies (group Tx1 1st examination). Read More

Cancer Manag Res 2019 31;11:401-409. Epub 2018 Dec 31.

Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Purpose: Leptomeningeal metastasis (LM) is an increasingly common complication of late-stage systemic cancer, for which there is no standard treatment. We analyzed outcome and toxicity in patients with LM undergoing craniospinal irradiation via helical tomotherapy (HT-CSI) at our institution.

Patients And Methods: The charts of 15 patients diagnosed with LM and undergoing HT-CSI between 2006 and 2014 were retrospectively assessed. Read More

Acta Reumatol Port 2018 Oct-Dec;43(4):291-303

BG University Hospital Bergmannsheil GmbH.

Introduction: Features suggestive of neuropathic pain (NP) have been described in RA in addition to nociceptive pain. We aimed to determine the clinical predictors of NP in RA patients and study its association with radiographic structural damage.

Methods: Cross-sectional study was performed with RA patients followed at our Rheumatology department. Read More

Dis Colon Rectum 2019 Jan 9. Epub 2019 Jan 9.

Background: With improving survival from colorectal cancer, there is a growing population of patients undergoing surveillance. National accreditation organizations have increasingly endorsed formal survivorship care planning. To effectively design patient-centered survivorship programs, an understanding of the prevalence of unmet psychosocial and symptomatic needs is required. Read More

Acta Oncol 2019 Jan 14:1-9. Epub 2019 Jan 14.

a Department of Oncology , Helsinki University Central Hospital , Helsinki , Finland.

Background: Oxaliplatin, combined with capecitabine (CAPOX) or infused 5-fluorouracil (FOLFOX), is standard of care in the adjuvant treatment of colorectal cancer (CRC). Prospective data on prevalence of oxaliplatin induced acute and long-term neuropathy in a real-life patient population and its effects on quality of life (QOL) and survival is limited, and scarce in CAPOX versus FOLFOX treated, especially in a subarctic climate.

Methods: One hundred forty-four adjuvant CRC patients (all 72 CAPOX cases and 72 matched FOLFOX controls) were analyzed regarding oxaliplatin induced sensory neuropathy, which was graded according to NCI-CTCAEv3. Read More

Trop Doct 2019 Jan 12:49475518823657. Epub 2019 Jan 12.

3 Professor, Department of Pediatrics (Emergency and Critical Care), PGIMER, Chandigarh, India.

Diphtheria, a vaccine preventable disease in children, is still being reported from India. Details of 99 children with a clinical diagnosis of diphtheria admitted to a paediatric tertiary care teaching and referral hospital between January 2008 and December 2015 were collected retrospectively and analysed. The median (interquartile range [IQR]) age of the study group was 7. Read More

Amyloid 2018 Dec 11;25(4):253-260. Epub 2019 Jan 11.

j Cardiology department , Bichat Claude Bernard Hospital, AP-HP, University of Paris-Sud , Paris , France.

Background: Hereditary transthyretin amyloidosis (ATTR) is a multisystemic disease involving mainly the peripheral nervous system and the heart. Liver transplantation (LT) is the reference treatment for ATTR neuropathy and preoperative detection of high risk patients is crucial. We aimed to document the causes of death of ATTR patients after LT, their temporal trends, and to evaluate whether the available preoperative tools that predict the risk of death after LT for hereditary ATTR amyloidosis matched with these trends. Read More

Cardiovasc Diabetol 2019 Jan 10;18(1). Epub 2019 Jan 10.

Department of Internal Medicine, School of Medicine, University Hospital Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rua Rodolpho Rocco, 255, Cidade Universitária, Rio de Janeiro, CEP 21941-913, Brazil.

Background: The prognostic importance of carotid atherosclerosis in individuals with diabetes is unsettled. We aimed to evaluate the relationships between parameters of carotid atherosclerosis and the future occurrence of micro- and cardiovascular complications in individuals with type 2 diabetes.

Methods: Ultrasonographic parameters of carotid atherosclerosis, intima-media thickness (CIMT) and plaques, were measured at baseline in 478 participants who were followed-up for a median of 10. Read More

Neurophysiol Clin 2019 Feb 4;49(1):59-67. Epub 2019 Jan 4.

EA 4391, Faculté de médecine de Créteil, Université Paris Est Créteil, 94010 Créteil, France; Service de neurologie, Groupe hospitalier Henri-Mondor, Centre hospitalier universitaire Henri-Mondor, Assistance publique-Hôpitaux de Paris, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France. Electronic address:

Objectives: Metabolic abnormalities, such as, glycemic disorders and metabolic syndrome (GDMS) are one of the main causes of peripheral neuropathies. The objective of this study was to evaluate the impact of adding specific coaching care (CC) to standard care (SC) of therapeutic education based on lifestyle recommendations for neuropathies associated with GDMS.

Methods: This prospective randomized study included two groups of four patients (SC vs. Read More

Medicine (Baltimore) 2019 Jan;98(1):e13795

Department of Nursing, Chung Hwa University of Medical Technology, Tainan, Taiwan.

De Quervain's disease, carpal tunnel syndrome (CTS), and trigger finger (digit) are three common pathological conditions of the hand. They are considered overuse syndromes and occur predominantly in females. The prevalence rate and cause-specific risks of these three tendinopathies have not yet been clarified. Read More

Support Care Cancer 2019 Jan 4. Epub 2019 Jan 4.

University Paris Descartes, Paris, France.

Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a devastating pain condition of cancer therapy that may force chemotherapy dose reduction or discontinuation. Since treatment options for CIPN are quite limited, we investigated the effect of 10% amitriptyline cream on neuropathic pain.

Patients And Methods: This pilot study enrolled patients with hematological or solid tumors presenting hands and feet CIPN (for less than 1 month without previous treatment for CIPN [Group 1]; for more than 1 month with previous treatment [Group 2]). Read More

Breast Cancer Res Treat 2019 Jan 3. Epub 2019 Jan 3.

GEICAM, Spanish Breast Cancer Group, Madrid, Spain.

Background: An important proportion of HER2-positive metastatic breast cancer patients do not respond to trastuzumab. The combination of dasatinib and trastuzumab has shown to be synergistic in preclinical models.

Methods: We conducted a phase II trial combining dasatinib 100 mg once daily with trastuzumab 2 mg/kg and paclitaxel 80 mg/m weekly. Read More

Rinsho Shinkeigaku 2019 Jan 29;59(1):27-32. Epub 2018 Dec 29.

Department of Neurology, National Hospital Organization Minamikyushu National Hospital.

Cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS) is a rare form of multisystem ataxia defined by a triad of cerebellar impairment, bilateral vestibular hypofunction, and somatosensory deficit. Here we present a patient with CANVAS. A 76-year-old woman whose parents were cousins had noted slowly worsening gait imbalance since age 67. Read More

J Gastrointest Oncol 2018 Dec;9(6):982-988

Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA.

Background: The safety and efficacy of FOLFIRINOX (FX) followed by consolidative chemoradiation (CRT) in borderline resectable (BRPC) and locally advanced pancreatic cancer (LAPC) has not been extensively studied. We sought to evaluate outcomes and toxicities of this regimen.

Methods: A retrospective review was performed of 33 patients with BRPC or LAPC treated with FX followed by CRT. Read More