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Support Care Cancer 2020 May 24. Epub 2020 May 24.

Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Purpose: Falls can occur in older cancer patients, but few studies have examined falls in an age-unspecified group of patients with locally advanced esophageal cancer. Because these patients are often administered neuropathy-inducing agents, are weak, and can develop orthostatic symptoms, examining falls appears relevant.

Methods: Electronic medical records were used to examine falls and their circumstances in locally advanced esophageal cancer patients treated with chemotherapy and radiation and often surgery. Read More

J Pediatr Gastroenterol Nutr 2020 Jun;70(6):841-848

Assistance Publique-Hôpitaux de Paris (APHP), Hôpital Necker Enfants Malades, Service de Gastroenterologie Pédiatrique, Paris.

Objectives: Neurological adverse effects (NAEs) induced by biotherapies have been reported in the literature mainly in adult patients with inflammatory bowel disease (IBD), rheumatic diseases, or psoriasis. There are scant data in children. Aims of this study are to report and describe noninfective NAE associated with anti-TNFα antibodies in pediatric IBD, and to evaluate their incidence. Read More

Lancet Oncol 2020 May 18. Epub 2020 May 18.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: Addition of trastuzumab to first-line chemotherapy improves overall survival in patients with HER2-positive metastatic gastric cancer. We assessed the safety and activity of pembrolizumab in combination with trastuzumab and chemotherapy in first-line HER2-positive metastatic oesophagogastric (gastric, oesophageal, or gastroesophageal junction) cancer.

Methods: This study was an investigator-initiated, open-label, non-randomised, single-arm, single centre, phase 2 trial in patients aged 18 years or older with HER2-positive metastatic oesophagogastric cancer. Read More

BMC Cancer 2020 May 20;20(1):449. Epub 2020 May 20.

Division of Hepato-Biliary-Pancreatic Medicine, Department of Gastroenterology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto, Tokyo, 135-8550, Japan.

Background: There is no established second-line treatment after failure of gemcitabine plus nab-paclitaxel (GnP) therapy for metastatic pancreatic cancer (MPC). The purpose of this study was to evaluate the efficacy and tolerability of the modified FOLFIRINOX (mFFX) as a second-line therapy for MPC and to investigate prognostic factors for survival.

Methods: From 2015 to 2019, we retrospectively reviewed the medical records of consecutive patients receiving mFFX for MPC after failure of GnP therapy. Read More

J Headache Pain 2020 May 19;21(1):54. Epub 2020 May 19.

Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, No. 201, Sec. 2, Shi-Pai Road, Bei-Tou District, Taipei City, Taiwan, 11217.

Background: Pregabalin is approved for the treatment of neuropathic pain, fibromyalgia, and seizure disorders, although the pivotal trials were mostly carried out in Europe or North America. The prescribing patterns among different indications in Asia have rarely been explored.

Methods: This was a population-based retrospective cohort study based on the National Health Insurance Research Database in Taiwan. Read More

Chin J Cancer Res 2020 Apr;32(2):149-162

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology, Peking University Cancer Hospital and Institute, Beijing 100142, China.

Objective: To compare the efficacy of platinum- and non-platinum-based regimens as first-line treatment for advanced triple-negative breast cancer (TNBC) and analyze the relationship between their efficacy and gene status.

Methods: Retrospectively analyze clinical data of 220 patients diagnosed pathologically with advanced TNBC and treated at the Department of Breast Oncology, Peking University Cancer Hospital from 2013 to 2018 and evaluate the efficacy of chemotherapy. A total of 114 patients had / gene tested by next generation sequencing (NGS) using peripheral blood, and we analyzed the correlation between their efficacy and / gene status. Read More

Int J Clin Oncol 2020 May 14. Epub 2020 May 14.

Division of Lower GI Surgery, Department of Surgery, Hyogo College of Medicine, Hyogo, Japan.

Background: Chemotherapy in relapsed colorectal cancer patients treated with oxaliplatin as adjuvant chemotherapy is under debate. REACT study aimed to investigate the efficacy of reintroducing modified FOLFOX6 (mFOLFOX6) or CAPOX with or without bevacizumab in recurrent colorectal cancer patients after oxaliplatin adjuvant chemotherapy.

Methods: Patients that participated in this trial had a medical history of adjuvant chemotherapy, including oxaliplatin with a cumulative dose greater than 400 mg/m, and recurrence that was diagnosed more six months post adjuvant chemotherapy. Read More

Surv Ophthalmol 2020 May 11. Epub 2020 May 11.

Service de Médecine Interne, Centre de Référence Maladies systémiques auto-immunes rares d'Ile de France, Hôpital Cochin, Université Paris Descartes, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France;. Electronic address:

In order to identify clinical presentations, main causes and prognosis of ophthalmic involvement in chronic lymphocytic leukemia (CLL), we performed a systematic review of articles describing CLL ophthalmic involvement in January 2019, using the Pubmed database. We found 86 articles describing 123 cases of patients with ophthalmic involvement associated with CLL. Ophthalmic symptoms were CLL's first manifestation in 25. Read More

J Neurogastroenterol Motil 2020 May 14. Epub 2020 May 14.

Department of biostatistics, Soonchunhyang University Seoul Hospital, Seoul, Korea.

Background/aims: We aim to evaluate associations between comorbidities, peripheral neuropathy, and spontaneous internal anal sphincter relaxation (SAR) in patients with defecatory disorders.

Methods: A patient is considered to exhibit SAR during high-resolution anorectal manometry (HR-ARM) when the nadir pressure is < 15 mmHg and the time from onset to relaxation was ≥ 15 seconds in the resting pressure frame. A case-control study was performed using HR-ARM data collected from 880 patients from January 2010 to May 2015. Read More

Gan To Kagaku Ryoho 2020 Jan;47(1):49-53

Dept. of Medical Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital.

FOLFOX therapy has been used for gastric cancer in Japan since 2017. We retrospectively analyzed the efficacy of FOLFOX therapy compared to that of FP. Forty-seven cases were evaluated between January 2010 and December 2018. Read More

J Ultrasound 2020 May 6. Epub 2020 May 6.

Radiology Institute, Fondazione IRCCS Policlinico San Matteo, Piazzale Golgi, Pavia, Italy.

Carpal tunnel release for compression of the median nerve at the wrist is a common procedure, often resulting in good clinical outcomes. There are, however, many anatomical variations in and around the carpal tunnel and it is important to be aware of these during carpal tunnel release. After surgery, recurrent carpal tunnel syndrome is uncommon, but difficult to diagnose and treat. Read More

Clin Cancer Res 2020 May 5. Epub 2020 May 5.

Hematology/Oncology, UNC Lineberger Comprehensive Cancer Centre.

Purpose: Although cisplatin plus radiotherapy is a standard treatment of locally advanced head and neck squamous cell carcinoma (LA-HNSCC), cisplatin contraindication is common. Radiation elicits and promotes tumor-directed immune-stimulation, which may potentiate anti-PD-1 therapy. We provide the first efficacy report of combined pembrolizumab and definitive radiotherapy in LA-HNSCC. Read More

Zhonghua Nei Ke Za Zhi 2020 May;59(5):360-365

Department of Rheumatology, Peking Union Medical College Hospital, Nation Clinical Research Center for Dermatologic and Rheumatologic Diseases of China, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To analyze the clinical and prognostic characteristics in patients with eosinophilic granulomatosis with polyangitis (EGPA). The clinical data of 146 EGPA patients hospitalized in Peking Union Medical College Hospital from 2000 to 2019 were analyzed retrospectively, including clinical manifestations, laboratory results, treatment, complications and outcome at discharge. Birmingham Vasculitis activity score-V3 (BVAS-V3) was used to evaluate disease activity. Read More

Intern Med J 2020 May 5. Epub 2020 May 5.

School of Pharmacy, The University of Queensland, Woolloongabba, QLD, Australia.

Background: The public subsidy in Australia of bortezomib (Velcade®) for untreated non-transplant multiple myeloma patients was based on the VISTA trial.

Aim: We aimed to ascertain the health outcomes of bortezomib in 'real world' transplant-ineligible elderly patients, compared to trial data.

Methods: Patient and treatment data were extracted from an oncology information system, laboratory information system, and medical chart audits for three Queensland public hospitals. Read More

Anticancer Res 2020 May;40(5):2853-2859

National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.

Background/aim: Definitive radiotherapy for bone and soft tissues sarcomas benefits patients deemed unfit for surgery; poor outcomes have been reported with conventional photons, while interesting preliminary results have been described with particle in single-Institution experiences. The aim of the study was to retrospectively evaluate preliminary results of carbon ion radiotherapy (CIRT) in patients with axial bone and soft tissue sarcomas (BSTS) treated with curative intent at the National Center for Oncological Hadrontherapy (CNAO).

Patients And Methods: From January 2013 to September 2018, 54 patients with axial BSTS were treated with CIRT at CNAO. Read More

Diabetes Res Clin Pract 2020 Apr 29;164:108168. Epub 2020 Apr 29.

School of Allied Health Sciences, Griffith University, Nathan, Queensland, Australia. Electronic address:

Aims: People with type 2 diabetes (T2D) have a greater prevalence of musculoskeletal and neuropathic pain. This exploratory analysis investigated whether exercise of different intensities leads to changes in self-reported musculoskeletal pain or symptoms of diabetic neuropathy in inactive individuals with type 2 diabetes.

Methods: Thirty-two inactive adults with T2D (59% male, mean age 58. Read More

Cardiovasc Diabetol 2020 May 2;19(1):50. Epub 2020 May 2.

Department of Internal Medicine, University Hospital Clementino Fraga Filho, School of Medicine, Universidade Federal do Rio de Janeiro, Rua Croton, 72, Jacarepagua, Rio de Janeiro, RJ, CEP 22750-240, Brazil.

Background: The prognostic importance of an increased visit-to-visit blood pressure variability (BP-VVV) for the future development of micro- and macrovascular complications in type 2 diabetes has been scarcely investigated and is largely unsettled. We aimed to evaluate it in a prospective long-term follow-up study with 632 individuals with type 2 diabetes.

Methods: BP-VVV parameters (systolic and diastolic standard deviations [SD] and variation coefficients) were measured during the first 24-months. Read More

BMJ 2020 04 30;369:m1701. Epub 2020 Apr 30.

Service d'Endocrinologie et des Maladies de la Reproduction, Hôpital Bicêtre, 94275 Le Kremlin-Bicêtre, France.

J Cancer Res Clin Oncol 2020 Apr 28. Epub 2020 Apr 28.

Department of Pediatric Oncology/Hematology and Stem Cell Transplantation, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany.

Purpose: We aimed at describing for the first time peripheral small-fiber neurotoxicity and pain sensitization in survivors of pediatric acute lymphoblastic leukemia after stem cell transplantation (SCT).

Methods: In a cross-sectional, retrospective, single-center study, we assessed 25 relapse-free long-term survivors (median age at SCT: 11 ± 4.9 years; median time between SCT and testing: 8. Read More

Neuropsychiatr Dis Treat 2020 15;16:969-974. Epub 2020 Apr 15.

Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, People's Republic of China.

Background: Surgery-related Guillain-Barré syndrome (GBS) is often underestimated and sometimes difficult to diagnose. This study aimed to elucidate the clinical features and electrophysiological subtypes of post-surgical GBS.

Methods: We retrospectively reviewed 17 patients who developed post-surgical GBS after a recent surgery between 2015 and 2019. Read More

Urology 2020 Apr 25. Epub 2020 Apr 25.

Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH; Department of Urology, UCSD, San Diego, CA. Electronic address:

Objective: To determine the predictive factors for kidney stone recurrence in type 2 diabetic patients.

Methods: A retrospective cohort study was conducted from 2013 to 2019 by using the database of diabetic patients diagnosed with kidney stone disease. The patients were divided into 2 groups according to stone disease status: recurrent stone and nonrecurrent stone. Read More

J Ultrasound 2020 Apr 22. Epub 2020 Apr 22.

Radiology Department, San Donato Hospital Group, Istituto Clinico Città di Brescia, Via Bartolomeo Gualla 15, 25128, Brescia, Italy.

Carpal tunnel syndrome (CTS) is the most frequent entrapment neuropathy of peripheral nerves, with an incidence of 1-3 patients in 1000. CTS typically occurs between 45 and 60 years of age, and it is more frequent in women than in men. The main cause of CTS is chronic compression of the median nerve and ischemic suffering secondary to increased pressure in the carpal tunnel. Read More

Int J Tuberc Lung Dis 2020 Apr;24(4):436-443

Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.

Data on the long-term use of linezolid (LZD) in the treatment of drug-resistant pulmonary tuberculosis (DR-PTB) are limited. To assess safety, tolerability and efficacy of LZD-containing regimens for the treatment of DR-PTB in the country of Georgia. A retrospective study was conducted among DR-PTB patients receiving LZD 600 mg/day as part of newly implemented regimens (bedaquiline or delamanid, repurposed and second-line drugs) from July 2014 to October 2015 in programmatic conditions and following WHO recommendations. Read More

Cancer 2020 Apr 21. Epub 2020 Apr 21.

School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: The National Cancer Institute's Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events, collected alongside the clinician-reported Common Terminology Criteria for Adverse Events, enables comparisons of patient and clinician reports on treatment toxicity.

Methods: In a multisite study of women receiving chemotherapy for early-stage breast cancer, symptom reports were collected on the same day from patients and their clinicians for 17 symptoms; their data were not shared with each other. The proportions of moderate, severe, or very severe patient-reported symptom severity were compared with the proportions of clinician-rated grade 2, 3, or 4 toxicity. Read More

J Hand Surg Asian Pac Vol 2020 Jun;25(2):164-171

Department of Orthpaedic Surgery, Graduate School of Medical Science Kanazawa University, Kanazawa, Japan.

Perineural adhesion is a potential complication of manipulating peripheral nerves. Using a model of median nerve manipulation in the carpal tunnel, perineural adhesion preventive effects of an alginate gel formulation were examined. After exposing carpal tunnels of Japanese white rabbits and dissecting the median nerve, the gliding floor was excised as much as possible and the transverse carpal ligament was repaired to induce a perineural tissue reaction. Read More

Medicine (Baltimore) 2020 Apr;99(16):e19791

Department of Physical Medicine and Rehabilitation, Catholic Kwandong University International St Mary's Hospital, Incheon.

Rationale: In the medical field, the use of 3-dimensional (3D) printing is increasing explosively and it is especially widespread in the clinical application of fabricating orthosis. Advantages of 3D-printed orthosis compared to conventional ones include its lower cost, easier modification, and faster fabrication. The 3D-printing technique makes it possible for physicians to easily create individual-tailored products. Read More

Eur J Ophthalmol 2020 Apr 20:1120672120914235. Epub 2020 Apr 20.

The New York Eye Cancer Center, New York, NY, USA.

Purpose: To investigate the safety and tolerability of total anterior segment palladium-103 (Pd) eye plaque brachytherapy for multifocal iris melanoma.

Methods: Interventional case series of 11 patients with multifocal iris melanomas. Anterior segment ultrasound revealed tumor size, location, and intraocular margins. Read More

BMJ Open Diabetes Res Care 2020 Apr;8(1)

Department of Translational Medicine - Hand Surgery, Lund University, Malmö, Sweden.

Introduction: Compression neuropathies (CN) in the upper extremity, the most common being carpal tunnel syndrome (CTS) and ulnar nerve entrapment (UNE), are frequent among patients with diabetes mellitus (DM). Earlier studies have shown contradicting results regarding DM as a risk factor for CN. Thus, the aim of the present population-based, longitudinal study was to explore potential associations between DM, CTS, and UNE during long-term follow-up. Read More

Clin Cancer Res 2020 Apr 16. Epub 2020 Apr 16.

Lymphoma/Myeloma, University of Texas MD Anderson Cancer Center.

Purpose: Treatment of multiple myeloma (MM) has evolved tremendously and optimal utilization of available therapies will ensure maximal patient benefits.

Experimental Design: We report the SWOG randomized phase 2 trial (S1304) comparing twice-weekly low-dose (27 mg/m; Arm 1) to high-dose carfilzomib (56 mg/m; Arm 2), both with dexamethasone, administered for 12 cycles (11 months) for relapsed and/or refractory MM with up to six prior lines of therapy (NCT01903811). The primary endpoint was progression-free survival (PFS), and patients on Arm 1 could crossover to Arm 2 after progression on treatment. Read More

Oncologist 2020 Apr 14;25(4):310-318. Epub 2019 Oct 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most debilitating long-term side effects in breast cancer survivors. We conducted a randomized controlled pilot trial to assess the feasibility, safety, and effects of an acupuncture intervention on CIPN in this population.

Patients And Methods: Women with stage I-III breast cancer with grade 1 or higher CIPN after taxane-containing adjuvant chemotherapy were randomized 1:1 to an immediate acupuncture (IA) arm or to a waitlist control group (CG). Read More

Diabetes Care 2020 Jun 15;43(6):1266-1275. Epub 2020 Apr 15.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Objective: To investigate the association of metabolic and lifestyle factors with possible diabetic polyneuropathy (DPN) and neuropathic pain in patients with early type 2 diabetes.

Research Design And Methods: We thoroughly characterized 6,726 patients with recently diagnosed diabetes. After a median of 2. Read More

J Orthop 2020 Nov-Dec;22:86-89. Epub 2020 Mar 31.

Northwell Health Department of Plastic Surgery, USA.

Background: Bilateral endoscopic carpal tunnel release is a modality offered for the treatment of the median nerve compression neuropathy. This retrospective study compares outcomes for patients undergoing open carpal tunnel release versus bilateral endoscopic carpal tunnel release. We hypothesized that there is no significant difference in postoperative complication rates between unilateral open and bilateral endoscopic carpal tunnel release surgery. Read More

PLoS One 2020 13;15(4):e0231502. Epub 2020 Apr 13.

Department of Medicine (Neurology), University of Ottawa, Ottawa, Canada.

Purpose: To assess whether there is a measurable impairment of median nerve conduction study parameters with uncomplicated distal radius fracture.

Methods: Patients were assessed prospectively at the time of cast removal (visit 1) after a standard 6-8 week immobilization for uncomplicated distal radius fracture. Patients with prior entrapment neuropathy or polyneuropathy were excluded. Read More

Clin Neurophysiol Pract 2020 20;5:79-82. Epub 2020 Mar 20.

Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Introduction: Median and ulnar motor nerve conduction study recording from median-innervated 2nd lumbrical and ulnar-innervated 1st palmar and 2nd dorsal interossei is designated in electrodiagnostic evaluation of carpal tunnel syndrome. In this technique, both responses are recorded by the same surface recording electrode placing over their shared motor point in mid-palm. To the best of our knowledge, this technique has never been utilized in demonstration of Martin-Gruber anastomosis. Read More

Clin Lymphoma Myeloma Leuk 2020 Mar 7. Epub 2020 Mar 7.

Janssen Global Services, LLC, Raritan, NJ.

Introduction: Bortezomib, melphalan, and prednisone (VMP) is the standard of care for transplant-ineligible newly diagnosed multiple myeloma. The phase III VISTA trial established the bortezomib dosing schedule for VMP. To mitigate bortezomib-associated toxicity, the phase III ALCYONE study of daratumumab plus VMP (D-VMP) versus VMP used modified bortezomib dosing. Read More

J Peripher Nerv Syst 2020 Apr 10. Epub 2020 Apr 10.

Department of Medicine, Division of Oncology, Medical School, University of Patras, Patras, Greece.

We report the outcome of a pilot, open-label study that tested the potential of lacosamide (200 mg/bi.d) as an effective and safe symptomatic treatment against acute painful oxaliplatin-induced peripheral neurotoxicity (OXAIPN). Lacosamide was introduced in 18 colorectal cancer patients with evidence of clinically significant acute, painful OXAIPN after infusion of the third course (T1) of oxaliplatin-based chemotherapy (FOLFOX4) and was maintained until completion of all 12 courses (T4). Read More

J Plast Reconstr Aesthet Surg 2020 Feb 19. Epub 2020 Feb 19.

Department of Plastic-, Reconstructive- and Hand Surgery, Franciscus Gasthuis & Vlietland, Rotterdam, the Netherlands; Department of Plastic-, Reconstructive- and Hand Surgery, Utrecht University Medical Center, Utrecht, the Netherlands.

Introduction: Tibial nerve entrapment is highly prevalent in diabetic subjects, resulting in significantly more neuropathic complaints and concomitant sensory disturbances. The study aim was to assess the impact of tarsal tunnel syndrome (TTS) and sensory loss at baseline on incident diabetic foot ulceration (DFU) in diabetic patients, since decompressing the tibial nerve might change the natural history of the disease.

Methods: In this study, 113 subjects with TTS (69 bilateral, 23 left-sided and 21 right-sided) participating in the prospective Rotterdam Diabetic Foot Study were compared to 303 diabetic controls without TTS, regarding incident DFU. Read More

Eur J Cancer 2020 May 8;131:27-36. Epub 2020 Apr 8.

Cancer Medecine Department, Gustave Roussy, Villejuif, France; Paris-Saclay University, Orsay, France. Electronic address:

Purpose: Second-line chemotherapy regimens have demonstrated poor benefit after failure of platinum-based chemotherapy in advanced non-squamous non-small-cell lung cancer (nsNSCLC).

Methods: In this multicentre, open-label phase III trial, patients with advanced nsNSCLC treated with one or two prior lines, including one platinum-based doublet, were centrally randomised to receive 90 mg/m of paclitaxel (D1, D8, D15) plus 10 mg/kg of bevacizumab (D1, D15) every 28 days or docetaxel (75 mg/m) every 21 days; crossover was allowed after disease progression. Primary end-point was progression-free survival (PFS). Read More

Clin Breast Cancer 2020 Mar 10. Epub 2020 Mar 10.

Praxis für interdisziplinäre Onkologie und Hämatologie, Freiburg, Germany. Electronic address:

Background: There are only scarce data on treatment of elderly patients with nab-paclitaxel for metastatic breast cancer, especially from the real-world setting. Here we present data from the noninterventional study NABUCCO with special focus on taxane-induced peripheral neuropathy (TIPN) in younger and elderly patients.

Patients And Methods: A total of 407 patients with HR-positive/HER2-negative metastatic breast cancer were enrolled between April 2012 and April 2015 into the prospective, multicenter, noninterventional study NABUCCO. Read More

Am J Hematol 2020 Apr 8. Epub 2020 Apr 8.

Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.

Disease Overview: Immunoglobulin light chain amyloidosis is a clonal, nonproliferative plasma cell disorder in which fragments of immunoglobulin light or heavy chain are deposited in tissues. Clinical features depend on organs involved but can include heart failure with preserved ejection fraction, nephrotic syndrome, hepatic dysfunction, peripheral/autonomic neuropathy, and "atypical smoldering multiple myeloma or monoclonal gammopathy undetermined significance (MGUS)."

Diagnosis: Tissue biopsy stained with Congo red demonstrating amyloid deposits with apple-green birefringence is required for diagnosis. Read More

JNCI Cancer Spectr 2020 Feb 17;4(1):pkz078. Epub 2019 Oct 17.

See the Notes section for the full list of authors' affiliations.

Background: Diabetes is a prognostic factor for some malignancies, but its association with outcome in patients with advanced or metastatic colorectal cancer (CRC) is less clear.

Methods: This cohort study was nested within a randomized trial of first-line chemotherapy and bevacizumab and/or cetuximab for advanced or metastatic CRC. Patients were enrolled at 508 community and academic centers throughout the National Clinical Trials Network. Read More

Ocul Oncol Pathol 2020 Mar 3;6(2):115-122. Epub 2019 Sep 3.

Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, Italy.

Introduction: Gamma knife radiosurgery (GKR) has shown promising results in the treatment of intraocular uveal melanoma (UM) in terms of local tumor control. However, GKR is not free from potentially sight-threatening side effects, including cataract, dry eye disease, vitreous hemorrhage, radiation retinopathy (RR), radiation maculopathy (RM), optic neuropathy, and neovascular glaucoma. The aim of this paper is to report our 20-year experience in UM management with GKR focusing on the rate of clinical treatment-induced complications. Read More

World Neurosurg 2020 Apr 3. Epub 2020 Apr 3.

Gamma Knife Center, Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia, USA.

Background: Crooke cell adenoma is a very rare subtype of pituitary neoplasm that is known to be clinically aggressive. These tumors can secrete adrenocorticotropic hormone or may be endocrinologically silent. We evaluated the effect of Gamma Knife radiosurgery (GKRS) on endocrine remission and tumor control. Read More

Ann Hematol 2020 May 4;99(5):1063-1072. Epub 2020 Apr 4.

Higashi Nagoya National Hospital, Nagoya, Japan.

These are the results of phase II study of bortezomib-melphalan-prednisolone (VMP) induction therapy followed by lenalidomide-dexamethasone (Rd) consolidation and lenalidomide maintenance in transplant-ineligible patients with newly diagnosed multiple myeloma (NDMM). The primary end point was progression-free survival (PFS). Secondary end points included overall survival (OS), overall response rates (ORRs), and safety. Read More

ESC Heart Fail 2020 Apr 2. Epub 2020 Apr 2.

Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.

Aims: Identification of patients with type 2 diabetes (T2D) at increased risk of incident heart failure (HF) beyond traditional risk factors such as prior myocardial infarction (MI) might allow selection of patients who would benefit from preventative treatment. Microvascular disease (MiVD) is thought to play a pathophysiological role in the development of HF in T2D; however, its association with new-onset HF with reduced or preserved ejection fraction has not been specifically defined.

Methods And Results: Patients in the Genetics of Diabetes Audit and Research Tayside Scotland study were linked to echocardiography, prescriptions, and clinical outcomes. Read More

Ann Hematol 2020 May 1;99(5):1049-1061. Epub 2020 Apr 1.

Department of Hemato-Oncology, University Hospital Ostrava, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.

Real-world data on regimens for relapsed/refractory multiple myeloma (RRMM) represent an important component of therapeutic decision-making. This multi-centric, retrospective, observational study conducted by the treating physicians evaluated the effectiveness and safety of ixazomib-lenalidomide-dexamethasone (IRd) in 155 patients who received ixazomib via early access programs in Greece, the UK, and the Czech Republic. Median age was 68 years; 17% had an Eastern Cooperative Oncology Group performance status ≥ 2; median number of prior therapies was 1 (range 1-7); 91%, 47%, and 17% had received prior bortezomib, thalidomide, and lenalidomide, respectively. Read More

J Neuroophthalmol 2020 Mar 26. Epub 2020 Mar 26.

Department of Ophthalmology (RCF, MTB, JJC), Mayo Clinic; Mayo Clinic (OMC), College of Medicine, Rochester, Minnesota; and Departments of Health Sciences Research (ERL, DOH), and Neurology (MTB, JPK, JJC), Mayo Clinic, Rochester, Minnesota.

Background: Nonarteritic anterior ischemic optic neuropathy (NAION) is a common cause of acute optic neuropathy in adults and is associated with vascular risk factors. Owing to the overlapping risk factor profiles between NAION and cerebral stroke, previous studies have produced conflicting results with regard to NAION as an independent risk factor for stroke.

Methods: A retrospective chart review was conducted using the Rochester Epidemiology Project database to identify all cases of NAION occurring among Olmsted County, Minnesota residents from January 1, 1990, through December 31, 2016. Read More

Anticancer Res 2020 Apr;40(4):2379-2386

Department of Pharmacy, Gifu University Hospital, Gifu, Japan.

Background/aim: The effect of renal dysfunction on the toxicity and efficacy of oxaliplatin remains unclear. We investigated the association between creatinine clearance (Ccr), a marker of renal function, and the toxicity and efficacy of oxaliplatin in patients with metastatic colorectal cancer (mCRC).

Patients And Methods: Patients with mCRC who received oxaliplatin-based chemotherapy as first-line treatment were included in this study. Read More

Fortschr Neurol Psychiatr 2020 Mar 31;88(3):198-209. Epub 2020 Mar 31.

Hereditary neuropathies are a group of diseases of which the most prevalent is Charcot Marie Tooth disease (CMT). From the clinical point of view pes cavus is a typical yet not specific sign for CMT. Motor signs like bilateral foot drop are dominant over sensory signs. Read More