13,977 results match your criteria Median Neuropathy


Development of MRC Centre MRI calf muscle fat fraction protocol as a sensitive outcome measure in Hereditary Sensory Neuropathy Type 1.

J Neurol Neurosurg Psychiatry 2019 Apr 17. Epub 2019 Apr 17.

MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK

Objectives: Hereditary sensory neuropathy type 1 (HSN1) is a rare, slowly progressive neuropathy causing profound sensory deficits and often severe motor loss. L-serine supplementation is a possible candidate therapy but the lack of responsive outcome measures is a barrier for undertaking clinical trials in HSN1. We performed a 12-month natural history study to characterise the phenotype of HSN1 and to identify responsive outcome measures. Read More

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http://dx.doi.org/10.1136/jnnp-2018-320198DOI Listing
April 2019
1 Read

A single-arm phase II trial of weekly nanoparticle albumin-bound paclitaxel (nab-paclitaxel) monotherapy after standard of chemotherapy for previously treated advanced non-small cell lung cancer.

Cancer Chemother Pharmacol 2019 Apr 16. Epub 2019 Apr 16.

Department of Thoracic Oncology and Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious Diseases Centre, Komagome Hospital, Honkomagome 3-18-22, Bunkyo, Tokyo, 113-0021, Japan.

Background: Few studies have investigated the clinical efficacy of third- and later-line of chemotherapy after standard chemotherapy for previously treated advanced non-small cell lung cancer (NSCLC). We prospectively evaluated the efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) following standard chemotherapies for previously treated advanced NSCLC.

Methods: The eligible patients having adequate organ functions with performance status 0-2 were enrolled after completing standard chemotherapy. Read More

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http://dx.doi.org/10.1007/s00280-019-03843-0DOI Listing
April 2019
1 Read

Resection of a superior mediastinal mature teratoma using intraoperative neural monitoring.

Ann Thorac Surg 2019 Apr 11. Epub 2019 Apr 11.

Division of Chest Surgery, Department of Surgery, Toho University School of Medicine, 6-11-1 Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan. Electronic address:

A 33-year-old female presented with a right cervical mass. Contrast computed tomography showed a multilocular tumor with a clear border and heterogeneous contents including fat and calcification. The tumor was located adjacent to the vagus and recurrent nerves. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975193051
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http://dx.doi.org/10.1016/j.athoracsur.2019.03.035DOI Listing
April 2019
1 Read

Shear wave elastography evaluation of the median and tibial nerve in diabetic peripheral neuropathy.

Quant Imaging Med Surg 2019 Feb;9(2):273-282

Department of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, China.

Background: To evaluate the value of shear wave elastography (SWE) in the detection of diabetic peripheral neuropathy (DPN) of the median and tibial nerves.

Methods: The study included 40 DPN patients, 40 diabetic mellitus (DM) patients without DPN, and 40 healthy subjects. High-resolution ultrasonography (US) and SWE were performed on the median nerve (MN) and tibial nerve (TN), and cross-sectional area (CSA) and nerve stiffness were measured. Read More

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http://dx.doi.org/10.21037/qims.2019.02.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414758PMC
February 2019
1 Read

Median Neuropathy After Blood Draw Mimics Painful Clenched Fist Syndrome in a Child.

Hand (N Y) 2019 Apr 8:1558944719837674. Epub 2019 Apr 8.

1 Washington University School of Medicine, Saint Louis, MO, USA.

Background: Clenched fist syndrome is a rare disorder, often attributed to a conversion disorder without anatomic basis. Here, we review the literature surrounding clenched fist syndrome and challenge the assumption it is always psychiatric in origin, via description of a case of clenched fist syndrome responsive to surgical nerve decompression.

Methods: An unusual case of clenched fist syndrome is reviewed and discussed. Read More

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http://dx.doi.org/10.1177/1558944719837674DOI Listing
April 2019
3 Reads

Gene-expression profiling of bortezomib added to standard chemoimmunotherapy for diffuse large B-cell lymphoma (REMoDL-B): an open-label, randomised, phase 3 trial.

Lancet Oncol 2019 Apr 1. Epub 2019 Apr 1.

Cancer Research UK Centre, University of Southampton, Southampton, UK. Electronic address:

Background: Biologically distinct subtypes of diffuse large B-cell lymphoma can be identified using gene-expression analysis to determine their cell of origin, corresponding to germinal centre or activated B cell. We aimed to investigate whether adding bortezomib to standard therapy could improve outcomes in patients with these subtypes.

Methods: In a randomised evaluation of molecular guided therapy for diffuse large B-cell lymphoma with bortezomib (REMoDL-B), an open-label, adaptive, randomised controlled, phase 3 superiority trial, participants were recruited from 107 cancer centres in the UK (n=94) and Switzerland (n=13). Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30935-5DOI Listing
April 2019
7 Reads

Sorafenib alone vs. sorafenib plus GEMOX as 1-line treatment for advanced HCC: the phase II randomised PRODIGE 10 trial.

Br J Cancer 2019 Apr 4. Epub 2019 Apr 4.

Gustave Roussy, Villejuif, France.

Background: Sorafenib remains one major first-line therapeutic options for advanced hepatocellular carcinoma (aHCC), with modest efficacy. We investigated the addition of gemcitabine and oxaliplatin (GEMOX) to sorafenib in aHCC patients.

Methods: Our multicentre phase II trial randomised aHCC first-line patients to sorafenib (400 mg BID) or sorafenib-GEMOX every 2 weeks (1000 mg/m gemcitabine; 100 mg/m oxaliplatin). Read More

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http://www.nature.com/articles/s41416-019-0443-4
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http://dx.doi.org/10.1038/s41416-019-0443-4DOI Listing
April 2019
6 Reads

Seven-Year Follow-Up Analysis of Adjuvant Paclitaxel and Trastuzumab Trial for Node-Negative, Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.

J Clin Oncol 2019 Apr 2:JCO1900066. Epub 2019 Apr 2.

1 Dana-Farber Cancer Institute, Boston, MA.

Purpose: The Adjuvant Paclitaxel and Trastuzumab trial was designed to address treatment of patients with small human epidermal growth factor receptor 2 (HER2)-positive breast cancer. The primary analysis of the Adjuvant Paclitaxel and Trastuzumab trial demonstrated a 3-year disease-free survival (DFS) of 98.7%. Read More

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http://ascopubs.org/doi/10.1200/JCO.19.00066
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http://dx.doi.org/10.1200/JCO.19.00066DOI Listing
April 2019
4 Reads

Dose-Adjusted EPOCH-R Compared With R-CHOP as Frontline Therapy for Diffuse Large B-Cell Lymphoma: Clinical Outcomes of the Phase III Intergroup Trial Alliance/CALGB 50303.

J Clin Oncol 2019 Apr 2:JCO1801994. Epub 2019 Apr 2.

14 Cornell University Medical College, New York, NY.

Purpose: Alliance/CALGB 50303 (NCT00118209), an intergroup, phase III study, compared dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (DA-EPOCH-R) with standard rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) as frontline therapy for diffuse large B-cell lymphoma.

Patients And Methods: Patients received six cycles of DA-EPOCH-R or R-CHOP. The primary objective was progression-free survival (PFS); secondary clinical objectives included response rate, overall survival (OS), and safety. Read More

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http://dx.doi.org/10.1200/JCO.18.01994DOI Listing
April 2019
2 Reads

Herbal medicinal products or preparations for neuropathic pain.

Cochrane Database Syst Rev 2019 Apr 2;4:CD010528. Epub 2019 Apr 2.

School of Health Sciences, Ulster University, Jordanstown campus, Shore Road, Newtownabbey, County Antrim, UK, BT37 0QB.

Background: Neuropathic pain is a consequence of damage to the central nervous system (CNS), for example, cerebrovascular accident, multiple sclerosis or spinal cord injury, or peripheral nervous system (PNS), for example, painful diabetic neuropathy (PDN), postherpetic neuralgia (PHN), or surgery. Evidence suggests that people suffering from neuropathic pain are likely to seek alternative modes of pain relief such as herbal medicinal products due to adverse events brought about by current pharmacological agents used to treat neuropathic pain. This review includes studies in which participants were treated with herbal medicinal products (topically or ingested) who had experienced neuropathic pain for at least three months. Read More

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http://dx.doi.org/10.1002/14651858.CD010528.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445324PMC
April 2019
4 Reads

Effectiveness of surgical versus conservative treatment for carpal tunnel syndrome: A systematic review, meta-analysis and qualitative analysis.

Hong Kong Physiother J 2018 Dec 2;38(2):91-114. Epub 2018 Jul 2.

Department of Hygiene, Epidemiology and Medical Statistics Medical School, National and Kapodistrian University of Athens, Greece.

Background: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy of the upper limb. Treatment options include physiotherapy, splinting, steroid injections or surgery.

Objective: To compare the effectiveness of surgical versus conservative treatment for CTS for symptom and functional improvement and improvement of neurophysiological parameters. Read More

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http://dx.doi.org/10.1142/S1013702518500087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405353PMC
December 2018
2 Reads

Use of graded Semmes Weinstein monofilament testing for ascertaining peripheral neuropathy in people with and without diabetes.

Diabetes Res Clin Pract 2019 Mar 25;151:1-10. Epub 2019 Mar 25.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive Kidney Diseases, National Institutes of Health, Phoenix, AZ, United States.

Aims: To assess peripheral neuropathy (PN) using graded Semmes Weinstein monofilaments (SWMs) and determine factors associated with PN among adult volunteers with and without diabetes.

Methods: Adult volunteers were assessed for distal sensory PN using three graded SWMs. Four PN levels were defined: 0 (no PN; felt all three filaments), 1 (subclinical PN; insensate to 1-g filament), 2 (insensate to 10-g), or 3 (insensate to 75-g). Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.029DOI Listing

Results From the First Multicenter, Open-label, Phase IIIb Study Investigating the Combination of Pertuzumab With Subcutaneous Trastuzumab and a Taxane in Patients With HER2-positive Metastatic Breast Cancer (SAPPHIRE).

Clin Breast Cancer 2019 Feb 27. Epub 2019 Feb 27.

Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia.

Introduction: The primary objective of this study was to assess the safety and tolerability of combination pertuzumab, subcutaneous trastuzumab (Herceptin), and investigator's choice of taxane chemotherapy in previously untreated patients with human epidermal growth factor receptor 2-positive metastatic breast cancer. Efficacy was a secondary objective.

Patients And Methods: This study was an open-label, non-randomized study of patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who had no previous systemic non-hormonal anti-cancer therapy for metastatic disease. Read More

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http://dx.doi.org/10.1016/j.clbc.2019.02.008DOI Listing
February 2019
1 Read

[Carpal tunnel syndrome secondary to a rare anatomical variation of the median nerve].

Pan Afr Med J 2018 20;31:39. Epub 2018 Sep 20.

Traumatologie-Orthopédie Aile 4, CHU Ibn Rochd, Casablanca, Maroc.

Carpal tunnel syndrome is one of the the most common reasons for consultation in hand surgery with an annual incidence of 300 per 100 000 inhabitants and, in France, of 80 000 surgical interventions. In most cases, carpal tunnel syndrome is idiopathic occurring without a recognizable cause. However, beyond these forms, the merging of several mechanisms can explain the cause-and-effect relationship of this pathology . Read More

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http://dx.doi.org/10.11604/pamj.2018.31.39.15526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430855PMC
April 2019
1 Read

Upper and lower limb motor axons demonstrate differential excitability and accommodation to strong hyperpolarising currents during induced hyperthermia.

J Neurophysiol 2019 Mar 27. Epub 2019 Mar 27.

Department of Clinical Neurophysiology, Portsmouth Hospitals NHS Trust.

Length-dependent peripheral neuropathy typically involves the insidious onset of sensory loss in the lower limbs before later progressing proximally. Recent evidence proposes HCN channels as dysfunctional in rodent models of peripheral neuropathy and differential expression of HCN channels in the lower limbs was hypothesised as a pathophysiological mechanism accounting for the pattern of symptomatology. We studied six healthy participants using motor axon excitability including strong and long (-70% & -100% TEh) hyperpolarising currents to preferably study HCN channel function from the median and tibial nerves from high(40%) and low (20%) threshold. Read More

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https://www.physiology.org/doi/10.1152/jn.00464.2018
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http://dx.doi.org/10.1152/jn.00464.2018DOI Listing
March 2019
1 Read

FDA Approval Summary: Brentuximab Vedotin in First-Line Treatment of Peripheral T-Cell Lymphoma.

Oncologist 2019 Mar 26. Epub 2019 Mar 26.

Office of Hematology and Oncology Products, Center for Drug Evaluation and Research, Silver Spring, Maryland, USA.

In November 2018, the U.S. Food and Drug Administration (FDA) approved brentuximab vedotin (BV) for the treatment of adult patients with previously untreated systemic anaplastic large cell lymphoma or other CD30-expressing peripheral T-cell lymphomas (PTCL), including angioimmunoblastic T-cell lymphoma and PTCL not otherwise specified, in combination with cyclophosphamide, doxorubicin, and prednisone (CHP). Read More

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http://dx.doi.org/10.1634/theoncologist.2019-0098DOI Listing
March 2019
3 Reads

[What do we know about diabetic retinopathy at the Sourô Sanou university medical center in Bobo-Dioulasso (CHUSS)?]

J Fr Ophtalmol 2019 Apr 23;42(4):361-367. Epub 2019 Mar 23.

Service d'ophtalmologie, centre hospitalier universitaire Yalgago Ouédraogo, 03 BP7022, Ouagadougou, Burkina Faso.

Introduction: Ocular damage is one of the numerous complications of diabetes. Proliferative diabetic retinopathy can result in blindness. The purpose of our work was to study the aspects of diabetic retinopathy on fundus examination in diabetic patients in Bobo-Dioulasso in a hospital environment. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.11.002DOI Listing
April 2019
2 Reads

Comparison of In Situ Versus Subcutaneous Versus Submuscular Transpositions in the Management of McGowan Stage III Cubital Tunnel Syndrome.

Hand (N Y) 2019 Mar 24:1558944719831387. Epub 2019 Mar 24.

1 Mayo Clinic, Rochester, MN, USA.

Background: The objective of the study was to evaluate and compare the clinical outcomes of in situ decompression with subcutaneous and submuscular transpositions for surgical management of advanced (McGowan stage III) cubital tunnel syndrome (CuTS).

Methods: A retrospective review of patients in our institution undergoing primary surgery for CuTS from February 1989 to May 2009 was performed. Patients with advanced CuTS with a minimum of 12 months of follow-up without any previous bony or soft tissue procedures around the elbow were included. Read More

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http://dx.doi.org/10.1177/1558944719831387DOI Listing
March 2019
4 Reads

Relationship between corneal confocal microscopy and markers of peripheral nerve structure and function in Type 2 diabetes.

Diabet Med 2019 Mar 21. Epub 2019 Mar 21.

Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia.

Aims: To investigate changes in corneal nerve morphology in Type 2 diabetes and to establish relationships between in vivo corneal confocal microscopy and markers of peripheral nerve structure and function.

Participants And Methods: We recruited 57 participants with Type 2 diabetes and 26 healthy controls of similar age and sex distribution. We also recruited a disease control group of 54 participants with Type 1 diabetes. Read More

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http://dx.doi.org/10.1111/dme.13952DOI Listing
March 2019
1 Read

Imaging in the diagnosis of ulnar nerve pathologies-a neoteric approach.

Insights Imaging 2019 Mar 20;10(1):37. Epub 2019 Mar 20.

Department of Orthopaedics, SMS Medical College, Jaipur, Rajasthan, India.

The ulnar nerve is a branch of the C8 and T1 nerve roots and arises from the medial cord of the brachial plexus. It supplies the intrinsic muscles of the hand and assists the median nerve in functioning of the flexors. Also known as the musician's nerve, it is the second most common nerve involved in compressive neuropathy following the median nerve. Read More

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http://dx.doi.org/10.1186/s13244-019-0714-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426899PMC

Examination of the Hand and Wrist.

N Engl J Med 2019 Mar;380(12):e15

From St. Elizabeth's Medical Center, Brighton, MA (C.S.D.); Tufts University School of Medicine (C.S.D.), Beth Israel Deaconess Medical Center (C.C.S.), and Harvard Medical School (C.C.S.) - all in Boston; and St. Mary's Medical Center, San Francisco (W.K.W.).

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http://www.nejm.org/doi/10.1056/NEJMvcm1407111
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http://dx.doi.org/10.1056/NEJMvcm1407111DOI Listing
March 2019
5 Reads

Linezolid for drug-resistant pulmonary tuberculosis.

Cochrane Database Syst Rev 2019 03 20;3:CD012836. Epub 2019 Mar 20.

Tropical and Infectious Diseases Unit, Royal Liverpool University Hospital, Liverpool, UK.

Background: Linezolid was recently re-classified as a Group A drug by the World Health Organization (WHO) for treatment of multi-drug resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB), suggesting that it should be included in the regimen for all patients unless contraindicated. Linezolid use carries a considerable risk of toxicity, with the optimal dose and duration remaining unclear. Current guidelines are mainly based on evidence from observational non-comparative studies. Read More

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http://dx.doi.org/10.1002/14651858.CD012836.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426281PMC
March 2019
1 Read

Conduction block in immune-mediated neuropathy: paranodopathy versus axonopathy.

Eur J Neurol 2019 Mar 18. Epub 2019 Mar 18.

Brain and Mind Centre, Sydney Medical School, The University of Sydney, NSW, Australia.

Background: Conduction block is a pathognomonic feature of immune-mediated neuropathies. The aim of this study was to advance understanding of pathophysiology and conduction block in chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN).

Methods: A multimodal approach was used, incorporating clinical phenotyping, neurophysiology, immunohistochemistry and structural assessments. Read More

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http://dx.doi.org/10.1111/ene.13953DOI Listing
March 2019
1 Read

Associations of Serum S100B and S100P with the Presence and Classification of Diabetic Peripheral Neuropathy in Adults With Type 2 Diabetes: A Case-Cohort Study.

Can J Diabetes 2019 Jan 11. Epub 2019 Jan 11.

Endocrinology and Metabolism Research Center, Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Objectives: Novel biomarkers of diabetic peripheral neuropathy provide potentially useful information for early identification and treatment of diabetic neuropathy, ultimately serving to reduce the burden of disease. This study was designed to investigate the potential associations of serum S100B and S100P (calcium-modulated proteins) with the presence and classification of diabetic peripheral neuropathy in adults with type 2 diabetes.

Methods: In a case-cohort setting, the data of 44 participants diagnosed with diabetic peripheral neuropathy, 44 control participants with type 2 diabetes but free of peripheral neuropathy and 87 healthy control individuals were collected and analyzed. Read More

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http://dx.doi.org/10.1016/j.jcjd.2019.01.003DOI Listing
January 2019
1 Read

A rare case of type 2 entrapment of the median nerve after posterior elbow dislocation with MRI and ultrasound correlation.

Skeletal Radiol 2019 Mar 13. Epub 2019 Mar 13.

Department of Orthopedics, Medical University of South Carolina, Charleston, SC, USA.

A 9-year-old boy sustained an ulnohumeral dislocation with a medial epicondyle fracture and experienced incomplete post-traumatic median nerve palsy in addition to post-traumatic stiffness following closed reduction and cast immobilization. When his motor palsy and stiffness did not improve, MRI and ultrasound were obtained, which demonstrated entrapment of the median nerve in an osseous tunnel at the fracture site, compatible with type 2 median nerve entrapment. Subsequently, the patient underwent surgery to mobilize the medial epicondyle and free the median nerve, resulting in improved range of motion, near complete restoration of motor function, and complete restoration of sensory function in the median nerve distribution within 6 months of surgery. Read More

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http://dx.doi.org/10.1007/s00256-019-03201-4DOI Listing
March 2019
1 Read

Hypoxic changes to the urothelium as a bystander of end-stage bladder disease.

J Pediatr Urol 2019 Feb 5. Epub 2019 Feb 5.

Department of Paediatric Urology, Leeds Children's Hospital, Leeds, LS1 3EX, UK; Jack Birch Unit, Department of Biology, University of York, Heslington, York YO10 5DD, UK. Electronic address:

Introduction: Urothelial cells harvested from benign diseased bladders have a compromised capacity to propagate or differentiate in vitro, potentially limiting their application in autologous tissue engineering approaches. The causative pathways behind this altered phenotype are unknown. The hypothesis is that hypoxic damage to the urothelium occurs as a bystander to chronic or recurrent episodes of infection and inflammation. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.01.012DOI Listing
February 2019

Assessing and monitoring the impact of the national newborn hearing screening program in Israel.

Isr J Health Policy Res 2019 Mar 11;8(1):30. Epub 2019 Mar 11.

Department of Maternal and Child Health, Public Health Services, Ministry of Health, Jerusalem, Israel.

Background: The Israeli Newborn Hearing Screening Program (NHSP) began operating nationally in January 2010. The program includes the Otoacoustic Emissions (OAE) test for all newborns and Automated Auditory Brainstem Response (A-ABR) test for failed OAE and infants at risk for auditory neuropathy spectrum disorders. NHSP targets are diagnosis of hearing impairment by age three months and initiation of habilitation by six months. Read More

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https://ijhpr.biomedcentral.com/articles/10.1186/s13584-019-
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http://dx.doi.org/10.1186/s13584-019-0296-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410489PMC
March 2019
3 Reads

Physical therapy management, surgical treatment, and patient-reported outcomes measures in a prospective observational cohort of patients with neurogenic thoracic outlet syndrome.

J Vasc Surg 2019 Mar 6. Epub 2019 Mar 6.

Center for Thoracic Outlet Syndrome, Washington University School of Medicine, St. Louis, Mo; Section of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Mo. Electronic address:

Objective: To assess the results of physical therapy management and surgical treatment in a prospective observational cohort of patients with neurogenic thoracic outlet syndrome (NTOS) using patient-reported outcomes measures.

Methods: Of 183 new patient referrals from July 1 to December 31, 2015, 150 (82%) met the established clinical diagnostic criteria for NTOS. All patients underwent an initial 6-week physical therapy trial. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.12.027DOI Listing
March 2019
2 Reads

Medical complications associated with substance use disorders in patients with type 2 diabetes and hypertension: Electronic health record findings.

Addiction 2019 Mar 9. Epub 2019 Mar 9.

Addiction Sciences Division, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, 3131 Harvey Avenue, Cincinnati, OH, 45229, USA.

Background And Aims: Screening for substance use disorder (SUD) in general medical settings may be particularly important in patients with comorbid health conditions exacerbated by SUD. This study evaluated whether SUD is associated with type 2 diabetes mellitus (T2DM)-complications in patients with co-occurring T2DM and hypertension.

Design: Analysis of a limited data set obtained through IBM Watson Health Explorys, a platform integrating data from electronic health records. Read More

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http://dx.doi.org/10.1111/add.14607DOI Listing
March 2019
4 Reads

Eribulin, trastuzumab, and pertuzumab as first-line therapy for patients with HER2-positive metastatic breast cancer: a phase II, multicenter, collaborative, open-label, single-arm clinical trial.

Invest New Drugs 2019 Mar 8. Epub 2019 Mar 8.

Department of Breast Surgery, Saitama Red Cross Hospital, Saitama, Japan.

Purpose To examine the efficacy and safety of triple therapy with eribulin, trastuzumab, and pertuzumab in patients with HER2-positive metastatic breast cancer (MBC) who never received any prior therapy in the first-line metastatic/advanced setting. Methods Eribulin 1.4 mg/m (days 1 and 8), trastuzumab 8 mg/kg over 90 min and 6 mg/kg over 30 min, and pertuzumab 840 mg/body over 60 min and 420 mg/body over 30 min were administered intravenously in 21-day cycles. Read More

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http://dx.doi.org/10.1007/s10637-019-00755-xDOI Listing
March 2019
2 Reads

Serum cytokine patterns in immunoglobulin m monoclonal gammopathy-associated polyneuropathy.

Muscle Nerve 2019 Mar 7. Epub 2019 Mar 7.

Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands.

Introduction: Polyneuropathy with immunoglobulin M monoclonal gammopathy (IgM-PNP) is associated with the presence of IgM antibodies against nerve constituents such as myelin associated glycoprotein (MAG) and gangliosides.

Methods: To test whether B-cell-stimulating cytokines are increased in IgM-PNP, we measured serum concentrations of 11 cytokines in 81 patients with IgM-PNP and 113 controls.

Results: Median interleukin (IL)-6 concentrations were higher in patients with IgM-PNP, and median IL-10 concentrations were higher in the subgroup with anti-MAG IgM antibodies. Read More

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http://dx.doi.org/10.1002/mus.26462DOI Listing

Is our treatment in type 1 diabetes mellitus (insulin therapy models, metabolic control) optimal for preventing cardiovascular autonomic neuropathy?

Endokrynol Pol 2019 Mar 7. Epub 2019 Mar 7.

Katedra i Klinika Chorób Metabolicznych, Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie, Poland.

Introduction: Long-term poor metabolic control promotes the occurrence of microvascular complications, such cardiovascular autonomic neuropathy and atherogenic hyperlipidaemia, which translates into increased mortality in patients with type 1 diabetes (T1DM).

Aims: To assess the prevalence of cardiovascular autonomic neuropathy (CAN) in patients with T1DM in relation to treatment method (continuous subcutaneous insulin infusion (CSII) versus multiple daily injections using pens (MDI)) and lipid control.

Material And Methods: The study group comprised 93 adults (60 women, 33 men), median age 31, with T1DM being treated in a local clinical centre in 2011-2015. Read More

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http://dx.doi.org/10.5603/EP.a2019.0011DOI Listing
March 2019
3 Reads

A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome.

Nat Commun 2019 03 4;10(1):1030. Epub 2019 Mar 4.

Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Science, University of Oxford, Botnar Research Centre, Windmill Road, Oxford, OX3 7LD, UK.

Carpal tunnel syndrome (CTS) is a common and disabling condition of the hand caused by entrapment of the median nerve at the level of the wrist. It is the commonest entrapment neuropathy, with estimates of prevalence ranging between 5-10%. Here, we undertake a genome-wide association study (GWAS) of an entrapment neuropathy, using 12,312 CTS cases and 389,344 controls identified in UK Biobank. Read More

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http://dx.doi.org/10.1038/s41467-019-08993-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399342PMC
March 2019
3 Reads
10.742 Impact Factor

Skull Base Manifestations of Erdheim-Chester Disease: A Case Series and Systematic Review.

Neurosurgery 2019 Mar 4. Epub 2019 Mar 4.

Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota.

Background: Erdheim-Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis. Up to 50% of patients develop central nervous system involvement, and a subset of these patients can present with isolated tumor-like masses.

Objective: To describe the skull base manifestations of ECD with an emphasis on aspects most pertinent to surgeons who may be referred such patients for primary evaluation. Read More

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http://dx.doi.org/10.1093/neuros/nyz027DOI Listing
March 2019
4 Reads

Incidence and determinants of diabetes-related lower limb amputations in Ghana, 2010-2015- a retrospective cohort study.

BMC Endocr Disord 2019 Mar 1;19(1):27. Epub 2019 Mar 1.

Faculty of Medicine and Department of Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.

Background: Diabetes-related lower limb amputations (LLA) are associated with significant morbidity and mortality. Although the incidence has decreased over the past two decades in most High-Income Countries, the situation in Low-Middle Income Countries (LMIC), especially those in sub-Saharan Africa (SSA) is not clear. We have determined the incidence and determinants of diabetes-related LLA in Ghana. Read More

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http://dx.doi.org/10.1186/s12902-019-0353-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397489PMC
March 2019
1 Read

Solvent-based paclitaxel or nab-paclitaxel for heavily treated relapsed/refractory small cell lung cancer: Retrospective single-institution observational study.

Medicine (Baltimore) 2019 Mar;98(9):e14758

Departments of Medical Oncology.

Treatment options for patients with relapsed/refractory small cell lung cancer (R/R SCLC) are limited, and the efficacy of salvage therapies for heavily treated patients should be assessed. Here, we evaluated the efficacy of paclitaxel (PTX) in R/R SCLC patients.A single-institute retrospective chart review was conducted. Read More

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http://dx.doi.org/10.1097/MD.0000000000014758DOI Listing

Baseline disease characteristics in Brazilian patients enrolled in Transthyretin Amyloidosis Outcome Survey (THAOS).

Arq Neuropsiquiatr 2019 Feb;77(2):96-100

Universidade Federal do Rio de Janeiro, Hospital Universitário Clementino Fraga Filho, Centro de Estudos em Paramiloidose Antônio Rodrigues de Mello.

Transthyretin amyloidosis (ATTR) is characterized by the deposit of mutant or wild-type transthyretin that forms amyloid fibrils, which are extracellularly deposited within tissues and organs. Clinical manifestations of familial amyloid polyneuropathy vary according to the mutation, age at onset and geographical location. This study aimed to describe baseline disease characteristics of Brazilian patients with transthyretin familial amyloid polyneuropathy (ATTR-FAP) enrolled in the Transthyretin Amyloidosis Outcome Survey (THAOS). Read More

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http://dx.doi.org/10.1590/0004-282X20180156DOI Listing
February 2019
1.006 Impact Factor

Paraneoplastic autoimmunity and small-cell lung cancer: Neurological and serological accompaniments.

Thorac Cancer 2019 Apr 27;10(4):1001-1004. Epub 2019 Feb 27.

Department of Neurology, Mayo Clinic, Rochester, USA.

Paraneoplastic neurological autoimmunity is often associated with small-cell lung cancer (SCLC), a highly malignant neuroendocrine tumor. Paraneoplastic autoimmunity often correlates with longer survival. We describe the paraneoplastic neurological manifestations of patients with SCLC with and without SCLC-predictive autoantibodies and the correlation between autoimmunity and survival. Read More

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http://doi.wiley.com/10.1111/1759-7714.13009
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http://dx.doi.org/10.1111/1759-7714.13009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449272PMC
April 2019
9 Reads

Report of a Transligamentous Ulnar Nerve Sensory Branch.

Hand (N Y) 2019 Feb 27:1558944719831338. Epub 2019 Feb 27.

1 MetroHealth Medical Center, Cleveland, OH, USA.

Background: Several anatomical variations of the median nerve recurrent motor branch have been described. No previous reports have described the anatomical variation of the ulnar nerve with respect to transverse carpal ligament. In this article, we present a patient with symptomatic compression of the ulnar nerve found to occur outside the Guyon canal due to a transligamentous course through the distal transverse carpal ligament. Read More

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http://dx.doi.org/10.1177/1558944719831338DOI Listing
February 2019
2 Reads

Complications of Percutaneous Bone Tumor Cryoablation: A 10-year Experience.

Radiology 2019 May 26;291(2):521-528. Epub 2019 Feb 26.

From the Department of Interventional Radiology, Nouvel Hôpital Civil, University Hospital of Strasbourg, 1 Place de l'Hôpital, BP 426, 67091 Strasbourg, France (P.A., R.L.C., J.C., G.K., J.G., A.G.); Clinical Investigation Center INSERM 1414, University Hospital of Rennes and University of Rennes, Rennes, France (C.R.); Division of Robotics and Department of Interventional Radiology, ICube, University of Strasbourg and Nouvel Hopital Civil, Strasbourg, France (P.R.); and Department of Radiology and Imaging, Queen Elizabeth Hospital, Hong Kong (J.B.C.).

Background Percutaneous cryoablation has been shown to be effective in the management of painful bone tumors. However, knowledge of the complication rate and risk factors for complication is currently lacking. Purpose To report the complication rate and associated risk factors for bone tumor cryoablation. Read More

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http://dx.doi.org/10.1148/radiol.2019181262DOI Listing
May 2019
1 Read

Randomized Controlled Trial of Physical Exercise in Diabetic Veterans With Length-Dependent Distal Symmetric Polyneuropathy.

Front Neurosci 2019 11;13:51. Epub 2019 Feb 11.

Research Service, Department of Veterans Affairs, Edward Hines Jr. VA Hospital, Hines, IL, United States.

Physical exercise is an essential adjunct to the management of patients with type 2 diabetes mellitus. Therapeutic interventions that improve blood flow to peripheral nerves, such as exercise, may slow the progression of neuropathy in the diabetic patient. This randomized clinical trial was conducted to determine whether a structured program of aerobic, isokinetic strength, or the combination of aerobic-isokinetic strength exercise intervention alters peripheral nerve function in glycemic-controlled diabetic patients with advanced length-dependent distal symmetric polyneuropathy. Read More

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http://dx.doi.org/10.3389/fnins.2019.00051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379046PMC
February 2019
2 Reads

Randomized phase II study evaluating weekly oral vinorelbine versus weekly paclitaxel in estrogen receptor-positive, HER2-negative patients with advanced breast cancer (NorBreast-231 trial).

Breast 2019 Jan 28;45:7-14. Epub 2019 Jan 28.

Pierre Fabre Médicament, 45 Place Abel Gance, 92654, Boulogne-Billancourt, France. Electronic address:

Background: Single-agent paclitaxel and vinorelbine are recommended treatments for advanced breast cancer (ABC) non-responsive to hormone therapy and without visceral crisis. This phase II trial compared first-line oral vinorelbine versus weekly paclitaxel for ABC.

Methods: Eligible female patients had measurable locally recurrent/metastatic estrogen receptor-positive HER2-negative breast cancer and had received prior endocrine therapy (any setting) but no chemotherapy for ABC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09609776193000
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http://dx.doi.org/10.1016/j.breast.2019.01.009DOI Listing
January 2019
8 Reads

Preliminary safety and efficacy of first-line pertuzumab combined with trastuzumab and taxane therapy for HER2-positive locally recurrent or metastatic breast cancer (PERUSE).

Ann Oncol 2019 Feb 23. Epub 2019 Feb 23.

Mount Vernon Cancer Centre, Middlesex, UK.

Background: Pertuzumab combined with trastuzumab and docetaxel is the standard first-line therapy for HER2-positive metastatic breast cancer, based on results from the phase III CLEOPATRA trial. PERUSE was designed to assess the safety and efficacy of investigator-selected taxane with pertuzumab and trastuzumab in this setting.

Patients And Methods: In the ongoing multicentre single-arm phase IIIb PERUSE study, patients with inoperable HER2-positive advanced breast cancer (locally recurrent/metastatic) (LR/MBC) and no prior systemic therapy for LR/MBC (except endocrine therapy) received docetaxel, paclitaxel or nab-paclitaxel with trastuzumab (8 mg/kg loading dose, then 6 mg/kg every 3 weeks [q3w]) and pertuzumab (840 mg loading dose, then 420 mg q3w) until disease progression or unacceptable toxicity. Read More

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https://academic.oup.com/annonc/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/annonc/mdz061DOI Listing
February 2019
5 Reads

The 2018 Chitranjan S. Ranawat, MD Award: Developing and Implementing a Novel Institutional Guideline Strategy Reduced Postoperative Opioid Prescribing After TKA and THA.

Clin Orthop Relat Res 2019 Jan;477(1):104-113

C. C. Wyles, M. Hevesi, R. T. Trousdale, M. W. Pagnano, T. M. Mabry Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA E. R. Trousdale, H. M. Gazelka Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA D. S. Ubl, E. B. Habermann Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery Surgical Outcomes Program, Mayo Clinic, Rochester, MN, USA.

Background: Opioid prescription management is challenging for orthopaedic surgeons, and we lack evidence-based guidelines for responsible opioid prescribing. Our institution recently developed opioid prescription guidelines for patients undergoing several common orthopaedic procedures including TKA and THA in an effort to reduce and standardize prescribing patterns.

Questions/purposes: (1) How do opioid prescriptions at discharge and 30-day refill rates change in opioid-naïve patients undergoing primary TKA and THA before and after implementation of a novel prescribing guideline strategy? (2) What patient, surgical, and in-hospital factors influence opioid prescription quantity and refill rate?

Methods: New institutional guidelines for patients undergoing TKA and THA recommend a maximum postoperative prescription of 400 oral morphine equivalents (OME), comparable to 50 tablets of 5 mg oxycodone or 80 tablets of 50 mg tramadol. Read More

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http://dx.doi.org/10.1007/s11999.0000000000000292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345303PMC
January 2019
1 Read

Phase II Trial of Eribulin in Patients With Metastatic Hormone Refractory Prostate Cancer: A Trial of the ECOG-ACRIN Cancer Research Group (E5805).

Am J Clin Oncol 2019 Apr;42(4):375-381

University of Kentucky, Lexington, KY.

Background: Eribulin mesylate, a synthetic analog of halichondrin B, is a novel tubulin-binding agent that inhibits cancer cell proliferation at low-nanomolar levels.

Methods: In a multicenter ECOG trial, patients with progressive metastatic CRPC, ECOG 0-2 were treated with eribulin 1.4 mg/m as an IV bolus over 5 minutes on days 1 and 8 of a 21-day cycle. Read More

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http://dx.doi.org/10.1097/COC.0000000000000526DOI Listing
April 2019
1 Read

Quantitative magnetic resonance evaluation of the trigeminal nerve in familial dysautonomia.

Clin Auton Res 2019 Feb 19. Epub 2019 Feb 19.

Department of Radiology, New York University School of Medicine, New York, NY, 10016, USA.

Purpose: Familial dysautonomia (FD) is a rare autosomal recessive disease that affects the development of sensory and autonomic neurons, including those in the cranial nerves. We aimed to determine whether conventional brain magnetic resonance imaging (MRI) could detect morphologic changes in the trigeminal nerves of these patients.

Methods: Cross-sectional analysis of brain MRI of patients with genetically confirmed FD and age- and sex-matched controls. Read More

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http://dx.doi.org/10.1007/s10286-019-00593-0DOI Listing
February 2019
2 Reads

Early progression of Krabbe disease in patients with symptom onset between 0 and 5 months.

Orphanet J Rare Dis 2019 02 18;14(1):46. Epub 2019 Feb 18.

Program for the Study of Neurodevelopment in Rare Disorders and Center for Rare Disease Therapy, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA, 15144, USA.

Background: Krabbe disease is a rare neurological disorder caused by a deficiency in the lysosomal enzyme, β-galactocerebrosidase, resulting in demyelination of the central and peripheral nervous systems. If left without treatment, Krabbe disease results in progressive neurodegeneration with reduced quality of life and early death. The purpose of this prospective study was to describe the natural progression of early onset Krabbe disease in a large cohort of patients. Read More

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http://dx.doi.org/10.1186/s13023-019-1018-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378723PMC
February 2019
3 Reads

Radiation tolerance of the optic pathway in patients treated with proton and photon radiotherapy.

Radiother Oncol 2019 Feb 31;131:112-119. Epub 2018 Dec 31.

Massachusetts General Hospital, Boston, USA. Electronic address:

Introduction: Radiation-induced optic neuropathy (RION) is a complication of radiation therapy (RT) that causes blindness. We aimed to define the tolerance of the anterior optic pathway to fractionated RT and identify risk factors for RION.

Materials/methods: Patients with chordoma or chondrosarcoma of the skull base treated with proton and photon therapy between 1983 and 2013, who received a minimum of 30 Gy (relative biologic effectiveness [RBE]) to the anterior optic pathway were assessed. Read More

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http://dx.doi.org/10.1016/j.radonc.2018.12.007DOI Listing
February 2019
8 Reads

Outcomes of decompressive surgery for cavernous sinus meningiomas: long-term follow-up in 50 patients.

J Neurosurg 2019 Feb 15:1-8. Epub 2019 Feb 15.

1Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah; and.

OBJECTIVECavernous sinus meningiomas are complex tumors that offer a perpetual challenge to skull base surgeons. The senior author has employed a management strategy for these lesions aimed at maximizing tumor control while minimizing neurological morbidity. This approach emphasizes combining "safe" tumor resection and direct decompression of the roof and lateral wall of the cavernous sinus as well as the optic nerve. Read More

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http://dx.doi.org/10.3171/2018.10.JNS181480DOI Listing
February 2019
1 Read

Predictive factors of prognosis after radiation and steroid pulse therapy in thyroid eye disease.

Sci Rep 2019 Feb 14;9(1):2027. Epub 2019 Feb 14.

Department of Radiology, Aichi Medical University Hospital, Aichi, Japan.

To identify predictive factors of prognosis after radiotherapy with concurrent steroid pulse therapy for thyroid eye disease, retrospective analyses were performed among 77 patients. Clinical activity score and magnetic resonance imaging were used to evaluate degrees of orbital inflammation. As a pre-treatment work-up, the thyroid-stimulating antibody (TSAb) level was measured. Read More

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http://dx.doi.org/10.1038/s41598-019-38640-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376132PMC
February 2019