128,104 results match your criteria Medial Collateral and Lateral Collateral Ligament Injury


Bilateral Lateral Rectus Recession for the Treatment of Recurrent Exotropia after Bilateral Medial Rectus Resection.

Ophthalmic Res 2018 Dec 6:1-5. Epub 2018 Dec 6.

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu,

Purpose: To evaluate the efficacy of bilateral lateral rectus muscle recession (BLR) to treat recurrent exotropia after bilateral medial rectus muscle resection (BMR).

Methods: Twenty-four patients who underwent BLR for recurrent exotropia and were followed up for more than 6 months were included in this retrospective study. All of them had prior BMR. Read More

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December 2018

Long-term seizure outcome in frontal lobe epilepsy surgery.

Epilepsy Behav 2018 Dec 3;90:93-98. Epub 2018 Dec 3.

IRCCS "NEUROMED", Pozzilli, IS, Italy; Department of Neurology and Psychiatry, "Sapienza" University of Rome, Italy.

Purpose: The purpose of this study was to report long-term seizure outcome in patients who underwent frontal lobe epilepsy (FLE) surgery.

Method: This retrospective study included 44 consecutive subjects who underwent resective surgery for intractable FLE at IRCCS NEUROMED (period 2001-2014), followed up for at least 2 years (mean: 8.7 years). Read More

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December 2018
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Function and energy consumption constrain neuronal biophysics in a canonical computation: Coincidence detection.

PLoS Comput Biol 2018 Dec 6;14(12):e1006612. Epub 2018 Dec 6.

Institute for Theoretical Biology, Department of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.

Neural morphology and membrane properties vary greatly between cell types in the nervous system. The computations and local circuit connectivity that neurons support are thought to be the key factors constraining the cells' biophysical properties. Nevertheless, additional constraints can be expected to further shape neuronal design. Read More

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December 2018
2 Reads

Intra-articular injection of hydrogen sulfide decreased the progression of gonarthrosis.

Can J Physiol Pharmacol 2018 Dec 6:1-8. Epub 2018 Dec 6.

d Department of Pharmacology, University of Giresun, Giresun, Turkey.

Hydrogen sulfide (HS) is found in both the plasma and synovial fluid of patients with gonarthrosis. In the present study, we investigated whether intra-articular injection of sodium hydrosulfide (NaSH) (1 mM, 30 μL), a HS donor, might affect gonarthrosis in rats. Gonarthrosis was induced surgically in the left knees of rats and left for 6 weeks for the development of disease. Read More

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December 2018
4 Reads

Medial elbow anatomy: A paradigm shift for UCL injury prevention and management.

Clin Anat 2018 Dec 6. Epub 2018 Dec 6.

Department of Clinical Anatomy, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.

Introduction: To improve the management outcomes and diagnostic accuracy of the ulnar collateral ligament (UCL) injury, the anatomy of the medial side of the elbow joint is necessary to be understood in terms of the periarticular surroundings rather than the specific ligaments. The aim of this study was to anatomically clarify the medial side of the elbow joint in terms of the tendinous structures and joint capsule.

Materials And Methods: We conducted a descriptive anatomical study of 23 embalmed cadaveric elbows. Read More

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December 2018

Co-localization of Middle East respiratory syndrome coronavirus (MERS-CoV) and dipeptidyl peptidase-4 in the respiratory tract and lymphoid tissues of pigs and llamas.

Transbound Emerg Dis 2018 Dec 6. Epub 2018 Dec 6.

UAB, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.

The present study investigated the co-localization of the Middle East respiratory syndrome coronavirus (MERS-CoV) and its receptor dipeptidyl peptidase-4 (DPP4) across respiratory and lymphoid organs of experimentally MERS-CoV infected pigs and llamas by immunohistochemistry (IHC). Also, scanning electron microscopy (SEM) was performed to assess the ciliary integrity of respiratory epithelial cells in both species. In pigs, on day 2 post-inoculation (p. Read More

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December 2018

Effect of selective serotonin reuptake inhibitor on prefrontal-striatal connectivity is dependent on the level of TNF-α in patients with major depressive disorder.

Psychol Med 2018 Dec 6:1-9. Epub 2018 Dec 6.

School of Traditional Chinese Medicine, Southern Medical University,Guangzhou,China.

Background: We hypothesize that the tumor necrosis factor-α (TNF-α) may play a role in disturbing the effect of selective serotonin reuptake inhibitor (SSRI) on the striatal connectivity in patients with major depressive disorder (MDD).

Methods: We performed a longitudinal observation by combining resting-state functional magnetic resonance imaging (rs-fMRI) and biochemical analyses to identify the abnormal striatal connectivity in MDD patients, and to evaluate the effect of TNF-α level on these abnormal connectivities during SSRI treatment. Eighty-five rs-fMRI scans were collected from 25 MDD patients and 35 healthy controls, and the scans were repeated for all the patients before and after a 6-week SSRI treatment. Read More

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December 2018

Mediolateral and dorsoventral projection patterns of cutaneous afferents within transverse planes of the mouse spinal dorsal horn.

J Comp Neurol 2018 Dec 6. Epub 2018 Dec 6.

Department of Physiology, Teikyo University School of Medicine, Tokyo, Japan.

The central projection patterns of cutaneous afferents from the forelimb and shoulder of mice were studied in the spinal dorsal horn after intracutaneous injection of AlexaFluor 488-conjugated and/or 594-conjugated cholera toxin subunit B (CTB). Based on their dermatomes, the following eight skin regions are thought to be innervated by spinal nerves from the sixth to eighth cervical spinal nerve roots: the dorsal surface of the shoulder, brachium, proximal forearm, distal forearm, hand, palmar surface of the second and third digits, and palm. The termination areas of afferents from the dorsal surface of the shoulder and forearm were narrow, distributed in a dorsoventral direction, and aligned in order from lateral to medial within the sixth to eighth cervical dorsal horns. Read More

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December 2018
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An original procedure for orbitonasal cutaneous infiltrative tumor repair, using combined forehead and melolabial propeller flaps.

Eur Arch Otorhinolaryngol 2018 Dec 5. Epub 2018 Dec 5.

Institut Universitaire de la Face et du Cou, Centre Hospitalier Universitaire de NICE, 31 Avenue de Valombrose, 06100, Nice, Alpes-Maritimes, France.

Introduction: Resections of cutaneous tumors in the medial orbitonasal region can be transfixing. Repairs using a single local flap run the risk of failure and that of secondary sinonasal fistula, especially in cases of surgery on a radiated field. We propose an original and reliable repair procedure using two pedicled regional flaps vascularized by two distinct arterial systems clinched together to reconstruct the mucosal and cutaneous planes. Read More

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December 2018

Adolescent social isolation affects parvalbumin expression in the medial prefrontal cortex in the MAM-E17 model of schizophrenia.

Metab Brain Dis 2018 Dec 5. Epub 2018 Dec 5.

Institute of Pharmacology, Polish Academy of Sciences, Department of Pharmacology, Laboratory of Pharmacology and Brain Biostructure, Smętna Street 12, 31-343, Kraków, Poland.

Altered parvalbumin (PV) expression is observed in the prefrontal cortex of subjects with schizophrenia. Environmental context, particularly during adolescence, might regulate PV expression. In the present study, we investigated the effect of adolescent social isolation (SI) on PV expression in the medial prefrontal cortex in a neurodevelopmental model (MAM-E17) of schizophrenia. Read More

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December 2018
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A literature review concerning contralateral approaches to paraclinoid internal carotid artery aneurysms.

Neurosurg Rev 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurosurgery, Mainz University Hospital, Langenbeckstraße 1, 55131, Mainz, Germany.

Ipsilateral approaches remain the standard technique for clipping paraclinoid aneurysms. Surgeons must however be prepared to deal with bony and neural structures restricting accessibility. The application of a contralateral approach has been proposed claiming that some structures in the region can be better exposed from this side. Read More

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December 2018
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Functional Connectivity of Paired Default Mode Network Subregions in Retinal Detachment.

Transl Vis Sci Technol 2018 Nov 30;7(6):15. Epub 2018 Nov 30.

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang, Jiangxi, China.

Purpose: To explore the difference of the default mode network (DMN) in patients with retinal detachment (RD) by the study of the resting state functional connectivity (rs-FC).

Methods: A total of 30 patients with RD (16 men, 14 women) and 30 similarly matched normal controls (NCs) were examined and recorded with rs-fMRI. The DMN was divided into eight core regions, and each rs-FC map of each subregion was obtained. Read More

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November 2018
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Cognitive Profiles and Atrophy Ratings on MRI in Senior Patients With Mild Cognitive Impairment.

Front Aging Neurosci 2018 21;10:384. Epub 2018 Nov 21.

Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

In this cross-sectional study, we sought to describe cognitive and neuroimaging profiles of Memory clinic patients with Mild Cognitive Impairment (MCI). 51 MCI patients and 51 controls, matched on age, sex, and socio-economic status (SES), were assessed with an extensive neuropsychological test battery that included a measure of intelligence (General Ability Index, "GAI," from WAIS-IV), and structural magnetic resonance imaging (MRI). MCI subtypes were determined after inclusion, and z-scores normalized to our control group were generated for each cognitive domain in each MCI participant. Read More

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November 2018
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Comparative study of the circumferential and volumetric analysis between conventional casting and three-dimensional scanning methods for transtibial socket: A preliminary study.

Proc Inst Mech Eng H 2018 Dec 6:954411918816124. Epub 2018 Dec 6.

1 Centre for Applied Biomechanics, Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia.

Transtibial prosthetic sockets can be fabricated either by the conventional way, which involve using plaster of Paris bandages for casting. This will include modifications through hand, scanning and digital imaging of software. The aim of this study is to determine the circumferential profiles and conduct a volumetric analysis of a conventional socket that has fabrication using biosculptor technology. Read More

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December 2018

Age-dependent behavioral and biochemical characterization of single APP knock-in mouse (APP) model of Alzheimer's disease.

Neurobiol Aging 2018 Nov 5;75:25-37. Epub 2018 Nov 5.

Canadian Center for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada. Electronic address:

Saito et al developed a novel amyloid precursor protein (APP) knock-in mouse model (APP) for Alzheimer's disease (AD) to overcome the problem of overexpression of APP in available transgenic mouse models. However, this new mouse model for AD is not fully characterized age-dependently with respect to behavioral and biochemical changes. Therefore, in the present study, we performed an age-dependent behavioral and biochemical characterization of this newly developed mouse model. Read More

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November 2018

Use of medial axis for reorientation by the Clark's nutcracker (Nucifraga columbiana).

Behav Processes 2018 Nov 30. Epub 2018 Nov 30.

Department of Neurosurgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA. Electronic address:

Many animals are challenged with the task of reorientation. Considerable research over the years has shown a diversity of species extract geometric information (e.g. Read More

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November 2018
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A Dissociation in Effects of Risperidone Monotherapy on Functional and Anatomical Connectivity Within the Default Mode Network.

Schizophr Bull 2018 Dec 2. Epub 2018 Dec 2.

Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Respective changes in functional and anatomical connectivities of default mode network (DMN) after antipsychotic treatment have been reported. However, alterations in structure-function coupling after treatment remain unknown. We performed diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging in 42 drug-naive first-episode schizophrenia patients (FESP) both at baseline and after 8-weeks risperidone monotherapy, and in 38 healthy volunteers. Read More

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December 2018

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding.

J Vis Exp 2018 Nov 14(141). Epub 2018 Nov 14.

Department of Psychiatry, Columbia University; Department of Pathology & Cell Biology, Columbia University Medical Center;

The goal of this protocol is to isolate oxytocin-receptor rich brain nuclei in the neonatal brain before and after first colostrum feeding. The expression of proteins known to respond to metabolic stress was measured in brain-nuclei isolates using Western blotting. This was done to assess whether metabolic stress-induced nutrient insufficiency in the body triggered neuronal stress. Read More

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November 2018

Use of Modified Islanded Paramedian Forehead Flap for Complex Periocular Facial Reconstruction.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Plastic Surgery, PGIMER, Chandigarh, India.

The paramedian forehead flap is a workhorse flap for reconstructing the nose and periorbital regions. Many variants are described including an islanded flap. However, eyebrow reconstruction is not usually performed with these flaps. Read More

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November 2018

Anatomic Landmarks in Transoral Oropharyngeal Surgery.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Otolaryngology Section, Head and Neck Surgery, Hospital Universitari Germans Trias i Pujol.

Introduction: Minimally invasive transoral surgery for oropharyngeal cancer is a challenge for head and neck surgeons because of the inside-out anatomic presentation and the confined workspace. This study was performed to describe the main neurovascular and muscular landmarks in a transoral approach. The authors propose an anatomic stratification for this surgery. Read More

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November 2018

Significance of Medial Osteotomy on the Olfactory Function in Patients Who Underwent Septorhinoplasty.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Otorhinolaryngology - Head and Neck Surgery, Medilife Hospital, Istanbul, Turkey.

Objective: This study was designed to explore the impact of medial osteotomy on olfactory function.

Methods: This nonrandomized, prospective study included 60 adult patients who underwent open technique septoplasty (group 1), rhinoplasty with only lateral osteotomy (group 2), and septorhinoplasty with medial and lateral osteotomies (group 3). Olfactory functions were evaluated by using the Connecticut Chemosensory Clinical Research Center (CCCRC) olfactory test. Read More

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November 2018

Indications and endonasal treatment of petrous apex cholesterol granulomas.

Curr Opin Otolaryngol Head Neck Surg 2018 Nov 30. Epub 2018 Nov 30.

Division of Rhinology, Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Purpose Of Review: Lesions of the petrous apex of the temporal bone can be challenging to access and approaches laterally through the mastoid as well as medially through an endonasal approach are utilized to access this region while preserving function of adjacent structures. Cholesterol granulomas of the petrous apex requiring surgery are marsupialized to prevent expansion of the inflamed cyst and relieve associated clinical symptoms. The endonasal approach to the petrous apex has in the past been limited to lesions medial to the internal carotid artery. Read More

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November 2018

Radiographic assessment of cattle hoofs (ungulae) of the Nellore breed: Reference standards.

Anat Histol Embryol 2018 Dec 3. Epub 2018 Dec 3.

Faculty of Veterinary Medicine and Animal Science, Department of Veterinary Medicine Clinic, University of Sao Paulo (FMVZ-USP), São Paulo, Brazil.

The purpose of this work was to determine a radiographic standard of normality for lateral and medial ungulae in 3-year-old bovine females of the Nellore breed. Twenty-six cows underwent radiographic exposure of the medial and lateral ungulae of the hindlimbs and forelimbs; abaxioaxial projections were used. The images were analyzed; distances were measured between the dorsal surface of the distal phalanx and the surface of the hoof capsule. Read More

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December 2018

Ultrasound assessment of carotid arteries: Current concepts, methodologies, diagnostic criteria, and technological advancements.

Echocardiography 2018 Dec;35(12):2079-2091

Department of Internal Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama.

Following cardiac disease and cancer, stroke continues to be the third leading cause of death and disability due to chronic disease in the developed world. Appropriate screening tools are integral to early detection and prevention of major cardiovascular events. In a carotid artery, the presence of increased intima-media thickness, plaque, or stenosis is associated with increased risk of a transient ischemic attack or a stroke. Read More

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December 2018
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Poor Performance on Single-Legged Hop Tests Associated With Development of Posttraumatic Knee Osteoarthritis After Anterior Cruciate Ligament Injury.

Orthop J Sports Med 2018 Nov 26;6(11):2325967118810775. Epub 2018 Nov 26.

Biomechanics and Movement Science Program, University of Delaware, Newark, Delaware, USA.

Background: The risk for knee osteoarthritis (OA) is substantially increased after anterior cruciate ligament (ACL) injury. Tools are needed to identify characteristics of patients after ACL injury who are most at risk for posttraumatic OA.

Purpose: To determine whether clinical measures of knee function after ACL injury are associated with the development of radiographic knee OA 5 years after injury. Read More

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November 2018
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Results and limits of posterior cranial vault expansion by osteotomy and internal distractors.

Surg Neurol Int 2018 30;9:217. Epub 2018 Oct 30.

Craniofacial Unit, Department of Pediatric Neurosurgery, Hôpital Necker-Enfants Malades, Paris, France.

Background: Expanding the posterior cranial vault has become a common procedure in the treatment of complex craniosynostosis. Several techniques are available to remodel the posterior vault. Aim of this study was to analyze the posterior vault distraction osteogenesis. Read More

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October 2018

Using Tibia Proximal Cut Autograft in Advanced Varus Knee Deformity in Total Knee Arthroplasty; Outcomes Compared to the Control Group.

Authors:
Aydin Arslan

Open Orthop J 2018 24;12:405-410. Epub 2018 Oct 24.

Elit Istanbul Medical Center, Orthopaedics and Traumatology, Istanbul Gelisim university, Istanbul, Turkey.

Background: The purpose of this study was to compare the outcomes of Total Knee Arthroplasty (TKA) performed for advanced varus knee deformity, which is performed by using tibia proximal cut bone for the reconstruction of the tibia proximal medial bone defects, with a control group consisting of TKAs which did not need reconstruction.

Methods: Patients in the present study underwent total knee arthroplasty between 2009 and 2015. 12 patients with advanced varus deformity who had undergone reconstruction with tibia proximal cut autograft and 15 patients who were randomly selected from patients who did not need reconstruction, were compared clinically and radiographically. Read More

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October 2018
3 Reads

Comparison of bone texture between normal individuals and patients with Kashin-Beck disease from plain radiographs in knee.

Sci Rep 2018 Nov 30;8(1):17510. Epub 2018 Nov 30.

Department of Integrative Molecular Biology, Umeå University, 90187, Umeå, Sweden.

To compare tibial bone texture between Kashin-Beck disease (KBD) patients and normal individuals from plain radiographs using an advanced image analysis. Plain knee radiographs were obtained from KBD patients (n = 49) and age-matched healthy controls (n = 98). KBD were graded with diagnostic criteria WS/T 207-2010. Read More

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November 2018
2 Reads

A posterior-anterior distinction between scene perception and scene construction in human medial parietal cortex.

J Neurosci 2018 Nov 30. Epub 2018 Nov 30.

Laboratory of Brain & Cognition, National Institute of Mental Health, Bethesda, MD, USA.

Human retrosplenial complex (RSC), located in medial parietal cortex, has been implicated in numerous cognitive functions, including scene perception, spatial navigation, and autobiographical memory retrieval. Recently, a posterior-anterior distinction within RSC was proposed, such that posterior aspects process scene-related visual information (constituting a "medial place area;" MPA), whereas anterior aspects process information that is vividly retrieved from memory, thereby supporting remembering and potentially navigation. Here, we tested this proposed distinction in a single group of participants (both male and female) using fMRI with both perceptual and mnemonic tasks. Read More

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November 2018

A sensorimotor pathway via higher-order thalamus.

J Neurosci 2018 Nov 30. Epub 2018 Nov 30.

Department of Neurobiology, University of Chicago, Chicago, Illinois, 60637

We now appreciate that sensory processing in cortex occurs not only via direct communication between primary to secondary areas but also via their parallel cortico-thalamo-cortical (i.e., transthalamic) pathways. Read More

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November 2018
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The deregulation of STIM1 and store operative calcium entry (SOCE) impaired aortic smooth muscle cells contractility in aortic medial degeneration.

Biosci Rep 2018 Nov 30. Epub 2018 Nov 30.

Cardiovascular surgery, Renmin hospital of Wuhan university, No. 99 ZhangZhiDong Street Wuchang District, Wuhan, Hubei Province, China, Wuhan, China

Background:  Micro-array analysis of clinical aortic samples suggested a potential role for STIM1 in the modulation of aortic medial degeneration (AMD), despite the uncertainty about STIM1 in normal aortic smooth muscle cells (ASMCs). Here, we aimed to explore changes in STIM1 expression in AMD, and the possible mechanisms. Methods: An AMD model was established using auto-delivery of angiotensin II into ApoE-/- mice. Read More

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November 2018

Dopaminergic modulation of pain signals in the medial prefrontal cortex: challenges and perspectives.

Neurosci Lett 2018 Nov 29. Epub 2018 Nov 29.

Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada. Electronic address:

Chronic pain is a massive socieoeconomic burden and is often refractory to treatment. To devise novel therapeutic interventions, it is important to understand in detail the processing of pain signals in the brain. Recent studies have revealed shared features between the brain's reward and pain systems. Read More

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November 2018

Compartimental harvesting of dual lymph node flap from the right supraclavicular area for the treatment of lower extremity lymphedema: A case series.

J Plast Reconstr Aesthet Surg 2018 Nov 19. Epub 2018 Nov 19.

Department of Plastic and Reconstructive Surgery, Centre for Surgical Treatment of Lymphedema, Università Cattolica del "Sacro Cuore" - Fondazione Policlinico "A. Gemelli" IRCSS - Largo A. Gemelli 8, 00169 Rome, Italy.

Background: We report our clinical experience of a supraclavicular lymph node flap (LNF) using a novel method of harvesting based on the compartimental lymphatic and vascular anatomy of the right posterior neck triangle, which allows to harvest two independent LNFs from the same donor site.

Patients And Methods: We report a case series of 10 consecutive patients affected by cancer-related lower extremity lymphedema, who underwent compartimental dual LNF transfer from the right supraclavicular area to the affected lower limb, from August 2015 to March 2017. The superficial compartment flap (venous flap along the external jugular vein) was anastomosed in a flow-through fashion along the course of the great saphenous vein in the knee region, whereas the deep compartment flap (transverse cervical artery/vein flap) was anastomosed in an end-to-end fashion to the medial sural artery and comitantes vein. Read More

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November 2018
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Outcome measures after medial ulnar collateral ligament reconstructions in a military population.

J Shoulder Elbow Surg 2018 Nov 28. Epub 2018 Nov 28.

Orthopaedic Surgery and Rehabilitation, William Beaumont Army Medical Center, El Paso, TX, USA.

Background: Medial ulnar collateral ligament (MUCL) reconstruction outcomes are well described in competitive throwers but not in nonthrowers. This investigation elucidated epidemiologic variables, functional outcomes, and prognostic factors after MUCL reconstruction in young active patients.

Methods: United States military service members undergoing MUCL reconstruction were isolated using the Management Analysis and Reporting Tool (M2) database from 2009 to 2016. Read More

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November 2018

Complications Associated With Medial Opening-Wedge High Tibial Osteotomy Using a Locking Plate: A Multicenter Study.

J Arthroplasty 2018 Nov 14. Epub 2018 Nov 14.

Department of Orthopaedic Surgery, Korea University Anam Hospital, Korea University School of Medicine, Seoul, South Korea.

Background: The aim of this study is to investigate complications following medial opening-wedge high tibial osteotomy using a locking plate. In addition, we aimed to compare postoperative outcomes between the complicated and the uncomplicated group.

Methods: This study enrolled 209 patients who underwent medial opening-wedge high tibial osteotomy between 2010 and 2015. Read More

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November 2018

Long-Term Results of Medial Unicompartmental Knee Arthroplasty for Knee Avascular Necrosis.

J Arthroplasty 2018 Nov 12. Epub 2018 Nov 12.

Aix-Marseille University, CNRS, ISM, Institute of Movement Science, Marseille, France; Department of Orthopaedics and Traumatology, APHM, Sainte Marguerite Hospital, Institute for Locomotion, Marseille, France.

Background: Numerous series have documented short and mid-term successes with cemented, metal-backed modern unicompartmental knee arthroplasty (UKA) for avascular osteonecrosis of the knee (AVN). However, data are lacking regarding long-term implant fixation and patient function. The aim of this study is therefore to evaluate the long-term clinical outcome and implant survivorship of patients who underwent UKA for medial knee osteonecrosis (ON). Read More

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November 2018

Echo-Doppler assessment of ventricular filling pressures in adult Fontan patients.

Int J Cardiol 2018 Oct 25. Epub 2018 Oct 25.

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, United States of America.

Background: Diastolic dysfunction is felt to be part of the natural history of patients with prior Fontan operation. Despite that, data on noninvasive assessment of diastolic function and ventricular filling pressures in Fontan patients are limited.

Methods: We included 45 adult Fontan patients who underwent right heart catheterization with pulmonary artery wedge pressure (PAWP) measurement and transthoracic echo-Doppler assessment within 7 days. Read More

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October 2018

A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System.

Neuron 2018 Nov 19. Epub 2018 Nov 19.

Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address:

Ventral tegmental area (VTA) dopamine (DA) neurons play a central role in mediating motivated behaviors, but the circuitry through which they signal positive and negative motivational stimuli is incompletely understood. Using in vivo fiber photometry, we simultaneously recorded activity in DA terminals in different nucleus accumbens (NAc) subnuclei during an aversive and reward conditioning task. We find that DA terminals in the ventral NAc medial shell (vNAcMed) are excited by unexpected aversive outcomes and to cues that predict them, whereas DA terminals in other NAc subregions are persistently depressed. Read More

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November 2018

DXA-Based 3D Analysis of the Cortical and Trabecular Bone of Hip Fracture Postmenopausal Women: A Case-Control Study.

J Clin Densitom 2018 Nov 13. Epub 2018 Nov 13.

Cetir Grup Mèdic, Barcelona, Spain.

Methods using statistical shape and appearance models have been proposed to analyze bone mineral density (BMD) in 3D from dual energy X-ray absorptiometry (DXA) scans. This paper presents a retrospective case-control study assessing the association of DXA-derived 3D measurements with osteoporotic hip fracture in postmenopausal women. Patients who experienced a hip fracture between 1 and 6 years from baseline and age-matched controls were included in this study. Read More

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November 2018

Inflammatory myofibroblastic tumour presenting as a medial eyelid mass in a child.

Can J Ophthalmol 2018 Dec 17;53(6):e241-e244. Epub 2018 Feb 17.

University of Miami Miller School of Medicine, Miami, Fla. Electronic address:

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December 2018