4,021,736 results match your criteria Med World Chronicle - Omnicare[Journal]


Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep.

Redox Biol 2019 Jan 29;22:101128. Epub 2019 Jan 29.

Programa de Fisiopatología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Av. Salvador 486, Providencia 7500922, Santiago, Chile; International Center for Andean Studies (INCAS), Universidad de Chile, Baquedano s/n, Putre, Chile. Electronic address:

Chronic hypobaric hypoxia during fetal and neonatal life induces neonatal pulmonary hypertension. Hypoxia and oxidative stress are driving this condition, which implies an increase generation of reactive oxygen species (ROS) and/or decreased antioxidant capacity. Melatonin has antioxidant properties that decrease oxidative stress and improves pulmonary vascular function when administered postnatally. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101128DOI Listing
January 2019

Marital quality, partner's engagement and continuous positive airway pressure adherence in obstructive sleep apnea.

Sleep Med 2018 Dec 26;55:56-61. Epub 2018 Dec 26.

HP2 Laboratory, INSERM U1042, Univ. Grenoble Alpes, Grenoble, France; EFCR Laboratory, Grenoble Alpes University Hospital, Grenoble, France. Electronic address:

Background: Continuous positive airway pressure (CPAP) is the first line therapy for obstructive sleep apnea (OSA) but its effectiveness requires high adherence. We aimed to assess the impacts of the spouse's/partner's involvement and the quality of the couple's relationship on CPAP adherence.

Methods: In a multicenter prospective study conducted in France, patients reported their subjective views regarding their partner's engagement in their CPAP treatment and the quality of their marital relationship using the Quality of Marriage Index. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.12.009DOI Listing
December 2018

Prolonged cortical silent period is related to poor fitness and fatigue, but not tumor necrosis factor, in Multiple Sclerosis.

Clin Neurophysiol 2019 Feb 4;130(4):474-483. Epub 2019 Feb 4.

Recovery and Performance Laboratory, Faculty of Medicine, L.A. Miller Centre, Memorial University of Newfoundland, St. John's, NL, Canada. Electronic address:

Objective: Poor fitness among people with Multiple Sclerosis (MS) aggravates disease symptoms. Whether low fitness levels accompany brain functioning changes is unknown.

Methods: MS patients (n = 82) completed a graded maximal exercise test, blood was drawn, and transcranial magnetic stimulation determined resting and active motor thresholds, motor evoked potential latency, and cortical silent period (CSP). Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.015DOI Listing
February 2019

Exploring socio-economic inequalities in the use of medicines: is the relation mediated by health status?

Public Health 2019 Feb 13;169:1-9. Epub 2019 Feb 13.

LMU Munich, University Hospital, Department of Psychiatry and Psychotherapy, Nußbaumstr. 7, 80336 Munich, Germany. Electronic address:

Objectives: This study evaluated mediating effects of the health status on the association between socio-economic status (SES) and medicine use. It was hypothesized that more privileged people show a reduced use of medicines, as compared with the underprivileged, because of their superior health status. It was further hypothesized that people may apply medication based on their type of health complaint (ill physical versus mental status). Read More

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http://dx.doi.org/10.1016/j.puhe.2018.12.018DOI Listing
February 2019

Iterative fully convolutional neural networks for automatic vertebra segmentation and identification.

Med Image Anal 2019 Feb 12;53:142-155. Epub 2019 Feb 12.

Image Sciences Institute, University Medical Center Utrecht, Room Q.02.4.45, 3508 GA Utrecht, P.O. Box 85500, The Netherlands.

Precise segmentation and anatomical identification of the vertebrae provides the basis for automatic analysis of the spine, such as detection of vertebral compression fractures or other abnormalities. Most dedicated spine CT and MR scans as well as scans of the chest, abdomen or neck cover only part of the spine. Segmentation and identification should therefore not rely on the visibility of certain vertebrae or a certain number of vertebrae. Read More

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http://dx.doi.org/10.1016/j.media.2019.02.005DOI Listing
February 2019

Maternal employment and child health in Nepal: The importance of job type and timing across the child's first five years.

Soc Sci Med 2019 Feb 6;224:94-105. Epub 2019 Feb 6.

Population Studies Center, University of Michigan, 426 Thompson Street, P.O. Box 1248, Ann Arbor, MI, 48106-1248, USA; Institute for Social and Environmental Research Nepal, Bharatpur Metropolitan City, Ward No. 15, Chitwan, Nepal. Electronic address:

The increase in female labor force participation (FLFP) in the paid labor market since the mid-1900s is one of the most pronounced family transitions and increasingly a global phenomenon. While this may improve income and bargaining power of the women, it may also increase stress and decrease time with children. Using the Chitwan Valley Family Study in Nepal, we explore the consequences of this transition for children's health by combining newly collected data on child health outcomes, quarterly data on women's employment, and data on households and neighborhoods. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.02.009DOI Listing
February 2019

The hidden cost of informal care: An empirical study on female caregivers' subjective well-being.

Soc Sci Med 2019 Feb 7;224:85-93. Epub 2019 Feb 7.

Harold Walter Siebens School of Business, Buena Vista University, Storm Lake, IA, USA. Electronic address:

Using data from the China Health and Nutrition Survey (CHNS), this study investigated the impact of informal care on female caregivers' subjective well-being in China. We found that informal care significantly reduced the subjective well-being of female caregivers using the instrumental variable (IV) ordered probit model. Our results revealed that the care effect on subjective well-being was more significant for rural caregivers than for urban caregivers. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.01.051DOI Listing
February 2019

Long-term mortality after DOAC-associated intracranial haemorrhage.

Thromb Res 2019 Feb 11;176:30-32. Epub 2019 Feb 11.

Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.thromres.2019.02.007DOI Listing
February 2019

Mediastinal, retroperitoneal, and subcutaneous emphysema due to sigmoid colon penetration: A case report and literature review.

Int J Surg Case Rep 2019 Feb 10;55:213-217. Epub 2019 Feb 10.

Department of Acute Care Surgery, Shimane University, Faculty of Medicine, Shimane, Japan.

Introduction: Mediastinal and subcutaneous emphysema usually result from spontaneous rupture of the alveolar wall. We present an extremely rare case of massive mediastinal, retroperitoneal, and subcutaneous emphysema due to the penetration of the colon into the mesentery.

Presentation Of Case: A 57-year-old man presented to our institution with a history of chest pain. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.02.003DOI Listing
February 2019

Dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones as anti-hepatoma agents by inhibiting NF-κB pathway activation.

Eur J Med Chem 2019 Feb 7;167:187-199. Epub 2019 Feb 7.

School of Pharmacy, The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, 264003, PR China. Electronic address:

To get new anti-hepatoma agents with anti-inflammatory activity and hypotoxicity, a series of dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones (BAPs, 25-82) were designed and synthesized. Many of them exhibited potential anti-hepatoma properties against human hepatocellular carcinoma cell lines (HepG2, QGY-7703, SMMC-7721) and hypotoxicity for human normal heptical cell line (HHL-5, LO2), and prominently inhibited lipopolysaccharides (LPS) induced IL-6, TNF-α secretion to exert its anti-inflammatory effect. Combining the data of cytotoxicity, cytocompatibility and anti-inflammatory activity, 3-pyridyl and -CF substituted 67 may be the potential anti-hepatoma agent. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.020DOI Listing
February 2019

Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.

Eur J Med Chem 2019 Feb 8;167:161-186. Epub 2019 Feb 8.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt. Electronic address:

Neuroinflammation and cholinergic deficit are key detrimental processes involved in Alzheimer's disease. Hence, in the search for novel and effective treatment strategies, the multi-target-directed ligand paradigm was applied to the rational design of two series of new hybrids endowed with anti-inflammatory and anticholinesterase activity via triple targeting properties, namely able to simultaneously hit cholinesterases, cyclooxygenase-2 (COX-2) and 15-lipoxygenase (15-LOX) enzymes. Among the synthesized compounds, triazoles 5b and 5d, and thiosemicarbazide hybrid 6e emerged as promising new hits, being able to effectively inhibit human butyrylcholinesterase (hBChE), COX-2 and 15-LOX enzymes with a higher inhibitory potency than the reference inhibitors tacrine (for hBChE inhibition), celecoxib (for COX-2 inhibition) and both NDGA and Zileuton (for 15-LOX inhibition). Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.012DOI Listing
February 2019

Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening.

Eur J Med Chem 2019 Feb 7;167:153-160. Epub 2019 Feb 7.

Faculty of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0914, Japan; Graduate School of Innovative Life Science, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

MutT homologue 1 (MTH1) protects the nucleotide pool from oxidative stress by hydrolyzing oxidized nucleoside triphosphates and prevents their incorporation into DNA. Cancer cells are dependent on the MTH1 activity for survival due to the high-level of reactive oxygen species in cancer cells; therefore, MTH1 is considered to be a novel target for treatment of various cancers. Here, we show by X-ray crystallographic screening using an in-house cocktail library that α-mangostin, a natural xanthone from mangosteen pericarp, binds to the active site of MTH1. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.011DOI Listing
February 2019

Repurposing nitrocatechols: 5-Nitro-α-cyanocarboxamide derivatives of caffeic acid and caffeic acid phenethyl ester effectively inhibit aggregation of tau-derived hexapeptide AcPHF6.

Eur J Med Chem 2019 Feb 4;167:146-152. Epub 2019 Feb 4.

CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal. Electronic address:

Polyphenols like caffeic acid and its phenethyl ester have been associated with potent anti-aggregating activity. Accordingly, we screened a library of polyphenols and synthetic derivatives thereof for their capacity to inhibit tau-aggregation using a thioflavin T-based fluorescence method. Our results show that the nitrocatechol scaffold is required for a significant anti-aggregating activity, which is enhanced by introducing bulky substituents at the side chain. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.006DOI Listing
February 2019

Synthesis and evaluation of tetrahydroisoquinoline-benzimidazole hybrids as multifunctional agents for the treatment of Alzheimer's disease.

Eur J Med Chem 2019 Feb 4;167:133-145. Epub 2019 Feb 4.

Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China. Electronic address:

A novel series of tetrahydroisoquinoline-benzimidazole hybrids have been designed and synthesized as multifunctional agents against Alzheimer's disease (AD). These compounds were evaluated for their inhibition of neuroinflammation and human β-secretase (hBACE1), and neuroprotective activity. Among them, compound BD3 possessed significant anti-neuroinflammatory activity (IC = 5. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.008DOI Listing
February 2019

A pan-genotypic Hepatitis C Virus NS5A amplification method for reliable genotyping and resistance testing.

J Clin Virol 2019 Jan 30;113:8-13. Epub 2019 Jan 30.

Institute of Virology, Heinrich-Heine-University, University Hospital, Düsseldorf, Germany.

Background: Chronic infection with the Hepatitis C Virus (HCV) is associated with the risk of progressive liver disease. Although, HCV treatment options and viral cure rates have tremendously increased over the last decade, all currently licensed combination therapies contain inhibitors of the replication complex NS5A. Resistance-associated substitutions (RAS) in NS5A can limit the efficacy of therapy; however, resistance testing is routinely not recommended for all patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13866532193002
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http://dx.doi.org/10.1016/j.jcv.2019.01.012DOI Listing
January 2019
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Factors associated with early seizures after surgery of unruptured intracranial aneurysms.

Clin Neurol Neurosurg 2019 Feb 8;178:93-96. Epub 2019 Feb 8.

Department of Cerebrovascular Surgery, International Medical Center, Saitama Medical University, Hidaka, Japan. Electronic address:

Objective: The aim of the study was to better define the incidence of and risk factors for early seizures after repair of unruptured intracranial aneurysms in modern microsurgical techniques.

Patients And Methods: The medical records of 414 consecutive patients who underwent neck clipping of unruptured intracranial aneurysms in our institution over a 5-year period were retrospectively reviewed. Clinical and neuroimaging variables were analyzed to investigate putative predictors of perioperative seizures using multivariate logistic regression analysis. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.02.007DOI Listing
February 2019

Quality of life in Swedish children receiving grommets - An analysis of pre- and postoperative results based on a national quality register.

Int J Pediatr Otorhinolaryngol 2019 Feb 6;120:44-50. Epub 2019 Feb 6.

Dpt of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital, Sweden. Electronic address:

Background: Otitis media with effusion (OME) and recurrent otitis media (rAOM) are two common diagnoses in childhood, both of which are treated with grommets, or ventilation tubes. It is known that affected children have a worse quality of life (QoL), and various questionnaires have been used to evaluate this. The national Swedish quality register for grommet insertions contains some QoL questions that have hitherto never been analysed. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.02.009DOI Listing
February 2019

RAMS: Remote and automatic mammogram screening.

Comput Biol Med 2019 Feb 5;107:18-29. Epub 2019 Feb 5.

Quality of Life Technology Laboratory, Department of Electrical and Computer Engineering, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX, 75080, USA. Electronic address:

About one in eight women in the U.S. will develop invasive breast cancer at some point in life. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.01.024DOI Listing
February 2019

Antiepileptic therapy approaches in KCNQ2 related epilepsy: A systematic review.

Eur J Med Genet 2019 Feb 13. Epub 2019 Feb 13.

Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Dr. von Haunersches Children's Hospital, LMU Munich, Lindwurmstraße4, 80337, Munich, Germany; Comprehensive Epilepsy Center for Children, Adolescents and Adults, LMU Munich, Lindwurmstraße 4, 80337, Munich, Germany. Electronic address:

Background: KCNQ2 related disorders comprise both benign seizure disorders and early onset epileptic encephalopathies. Especially within the latter group, patients suffer from refractory seizures to standard antiepileptic drugs and developmental delay. Besides the hope of personalized medical approaches to treat the recently unraveled large amount of genetic channelopathies, there are sparse systematic data on treatment responses in KCNQ2 related epilepsy in larger cohorts. Read More

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http://dx.doi.org/10.1016/j.ejmg.2019.02.001DOI Listing
February 2019

Cough in exercise and athletes.

Pulm Pharmacol Ther 2019 Feb 13. Epub 2019 Feb 13.

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Canada.

In the general population, particularly in individuals with asthma, cough is a common symptom, often reported after exertion, although regular exercise may be associated with a reduction in the prevalence of cough. In athletes, exercise-induced cough is also a particularly frequent symptom. The main etiologies of cough in athletes are somewhat similar to non-athletes, including asthma/airway hyperresponsiveness, upper airways disorders such as allergic or non-allergic rhinitis, and exercise-induced laryngeal obstruction, although these conditions are more frequently observed in athletes. Read More

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http://dx.doi.org/10.1016/j.pupt.2019.02.003DOI Listing
February 2019

Improving child weight management uptake through enhanced National Child Measurement Programme parental feedback letters: A randomised controlled trial.

Prev Med 2019 Feb 13. Epub 2019 Feb 13.

PHE Behavioural Insights Team (PHE BI), Research, Translation & Innovation Division, 6th Floor, Wellington House, 133-155 Waterloo Road, London SE1 8UG, United Kingdom of Great Britain and Northern Ireland.

This single-blind, pragmatic, cluster randomised controlled trial aims to investigate uptake of children's weight management services in response to enhanced National Child Measurement Programme (NCMP) letters providing weight status feedback to parents in three English counties in 2015. Parents of 2642 overweight or very overweight (obese) children aged 10-11 years received an intervention or control letter informing them of their child's weight status. Intervention letters included (i) a visual tool to help weight status recognition, (ii) a social norms statement, and for very overweight children, (iii) a prepopulated booking form for weight management services. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.01.023DOI Listing
February 2019

Slow shift of dead zone after an abrupt shift of the light-dark cycle.

Brain Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Anatomy and Neurobiology, Kindai University Faculty of Medicine, Ohnohigashi, Osakasayama 589-8511, Japan. Electronic address:

The suprachiasmatic nucleus (SCN) is the center of the mammalian circadian system. Environmental photic signals shifts the phase of the circadian rhythm in the SCN except during the dead zone, when the photic signal is gated somewhere on the way from the retina to the neurons in the SCN. Here we examined the phase of the dead zone after an abrupt delay of the LD cycles for several days by observing the mc-Fos induction in the SCN by light pulses. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.02.014DOI Listing
February 2019

miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta.

Dev Biol 2019 Feb 13. Epub 2019 Feb 13.

Department of Cell and Developmental Biology, Weill Cornell Medical College, 1300 York Avenue, Box 60, New York, NY 10065. Electronic address:

A functional placenta develops through a delicate interplay of its vascular and trophoblast compartments. We have identified a previously unknown expression domain for the endothelial-specific microRNA miR-126 in trophoblasts of murine and human placentas. Here, we determine the role of miR-126 in placental development using a mouse model with a targeted deletion of miR-126. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.01.019DOI Listing
February 2019

Association Between Activation of the Programmed Cell Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) Pathway and Pain in Patients with Cancer.

Med Sci Monit 2019 Feb 16;25:1275-1282. Epub 2019 Feb 16.

Department of Palliative Care, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).

BACKGROUND The aim of this study was to investigate the clinical correlation between sPD-1 (soluble programmed cell death-1) and PD-1 (programmed cell death-1) expression and cancer pain. MATERIAL AND METHODS sPD-1 content in peripheral blood was determined by enzyme-linked immunosorbent assay (ELISA). T cell surface-positive rate was determined by flow cytometry, and the correlation of clinical characteristics of patients with cancer pain was analyzed. Read More

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http://dx.doi.org/10.12659/MSM.912632DOI Listing
February 2019

Strategies for controlling egress of therapeutic cells from hydrogel microcapsules.

J Tissue Eng Regen Med 2019 Feb 16. Epub 2019 Feb 16.

Department of Physics, University of Ottawa, Ottawa, Canada.

Endothelial progenitor cells (EPCs) and human mesenchymal stem cells (hMSCs) have shown great regenerative potential to repair damaged tissue; however, their injection in vivo results in low retention and poor cell survival. Early clinical research has focused on cell-encapsulation, to improve viability and integration of delivered cells. However, this strategy has been limited by the inability to reproduce large volumes of standardized microcapsules and the lack of information on cell-specific egress and timed release from hydrogel microcapsules. Read More

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http://dx.doi.org/10.1002/term.2818DOI Listing
February 2019

Zika transmission patterns: a meta-review.

Trop Med Int Health 2019 Feb 16. Epub 2019 Feb 16.

Institute of Public Health, University of Heidelberg, Germany.

Objective: To assesses what is known and identify knowledge gaps for Zika virus (ZIKV) transmission patterns.

Methods: Meta-review searching the databases BioSys; Cochrane Infectious Diseases Group Specialised Register and Cochrane Central Register of Controlled Trials; EMBASE; Google Scholar; LILACS; MEDLINE (PubMed); Web of Science; and WHOLIS with the term "ZIKA". Systematic reviews and reviews specifying the search methods and describing potential modes of transmission were eligible for analysis. Read More

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http://dx.doi.org/10.1111/tmi.13216DOI Listing
February 2019

Interventions for the control of Aedes aegypti in Latin America and the Caribbean: Systematic Review and Meta-Analysis.

Trop Med Int Health 2019 Feb 16. Epub 2019 Feb 16.

Instituto de Efectividad Clínica y Sanitaria, Centro de Investigación de Epidemiología y Salud Pública, Argentina.

Objective: To determine the effectiveness and degree of implementation of interventions for the control of Aedes aegypti in Latin America and the Caribbean (LAC) as reported in scientific literature.

Methods: We searched MEDLINE, EMBASE, CENTRAL, SOCINDEX and LILACS, for experimental and observational studies, economic assessments and qualitative experiences carried out in LAC from 2000 to 2016. We assessed incidence and morbimortality of Aedes aegypti-related diseases and entomological indices: Breteau (containers), House, and Pupae per Person. Read More

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http://dx.doi.org/10.1111/tmi.13217DOI Listing
February 2019

Automated Pectoral Muscle Identification on MLO-view Mammograms: Comparison of Deep Neural Network to Conventional Computer Vision.

Med Phys 2019 Feb 16. Epub 2019 Feb 16.

School of Data and Computer Science, Sun Yat-Sen University, Guangzhou, 510275, P.R. China.

Objectives: To develop a fully automated deep learning approach for identification of the pectoral muscle on mediolateral oblique (MLO) view mammograms and evaluate its performance in comparison to our previously developed texture-field orientation (TFO) method using conventional image feature analysis. Pectoral muscle segmentation is an important step for automated image analyses such as breast density or parenchymal pattern classification, lesion detection, and multi-view correlation.

Materials And Methods: Institutional Review Board (IRB) approval was obtained before data collection. Read More

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http://dx.doi.org/10.1002/mp.13451DOI Listing
February 2019
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Co-culture with monocytes/macrophages modulates osteogenic differentiation of adipose-derived mesenchymal stromal cells on PLGA/PCL scaffolds.

J Tissue Eng Regen Med 2019 Feb 16. Epub 2019 Feb 16.

Department of Biomaterials, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands.

The effects of immune cells, in particular macrophages, on the behavior of mesenchymal stem cells (MSCs) have recently gained much attention for MSCs-based tissue-engineered constructs. This study aimed to evaluate the effect of monocytes/macrophages on the osteogenic differentiation of adipose-derived mesenchymal stromal cells (ADMSCs) in three-dimensional (3D) co-cultures. For this, we co-cultured THP-1 monocytes, M1 macrophages or M2 macrophages with ADMSCs on 3D poly (lactic-co-glycolic) acid (PLGA)/polycaprolactone (PCL) scaffolds using osteogenic medium for up to 42 days. Read More

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http://dx.doi.org/10.1002/term.2826DOI Listing
February 2019

Deprescribing cholinesterase inhibitors and memantine in dementia: guideline summary.

Med J Aust 2019 Feb 16. Epub 2019 Feb 16.

NHMRC Cognitive Decline Partnership Centre, Kolling Institute of Medical Research, Northern Clinical School, University of Sydney, Sydney, NSW.

Introduction: Cholinesterase inhibitors (ChEIs) and memantine are medications used to treat the symptoms of specific types of dementia. Their benefits and harms can change over time, particularly during long term use. Therefore, appropriate use of ChEIs and memantine involves both prescribing these medications to individuals who are likely to benefit, and deprescribing (withdrawing) them from individuals when the risks outweigh the benefits. Read More

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http://dx.doi.org/10.5694/mja2.50015DOI Listing
February 2019

Longitudinal assessment of cerebral blood flow changes following carotid artery stenting and endarterectomy.

Radiol Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.

Background: Carotid artery stenting (CAS) and endarterectomy (CEA) are major treatment strategies for patients with internal carotid artery (ICA) stenosis; however, the dynamic cerebral blood flow (CBF) changes after CAS and CEA remain unclear.

Purpose: This study aimed to monitor consecutive CBF changes at 24-h intervals in patients who underwent CAS and CEA to explore the potential pattern of CBF alternation and compare the effect on CBF changes of different surgical methods.

Methods: Thirty-two patients (28 males and 4 females; age = 63. Read More

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http://dx.doi.org/10.1007/s11547-018-00986-7DOI Listing
February 2019

Concomitant radiotherapy and TKI in metastatic EGFR- or ALK-mutated non-small cell lung cancer: a multicentric analysis on behalf of AIRO lung cancer study group.

Radiol Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Oncology Radiation Therapy Unit, Careggi University Hospital, Florence, Italy.

Purpose: To investigate the role of radiotherapy (RT) in the management of EGFR- or ALK-mutated metastatic non-small cell lung cancer (NSCLC) treated with TKI.

Materials And Methods: Clinical data of 106 patients (pts) from five Institutions treated with RT concomitant to TKI were retrospectively revised. Overall survival (OS) and toxicities were analyzed as endpoints of the study. Read More

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http://dx.doi.org/10.1007/s11547-019-00999-wDOI Listing
February 2019

Radiation dose in nuclear medicine: the hybrid imaging.

Radiol Med 2019 Feb 15. Epub 2019 Feb 15.

Dipartimento di Biomedicina e Prevenzione, Università di Roma Tor Vergata, Rome, Italy.

Hybrid imaging procedures such as single-photon emission computed tomography/computed tomography (SPECT/CT) and positron emission tomography/computed tomography (PET/CT) showed a rapid diffusion in recent years because of their high sensitivity, specificity, and accuracy, due to a more accurate localization and definition of scintigraphic findings. However, hybrid systems inevitably lead to an increase in patient radiation exposure because of the added CT component. Effective doses due to the radiopharmaceuticals can be estimated by multiplying the administered activities by the effective dose coefficients, while for the CT component the dose-length product can be multiplied by a conversion coefficient k. Read More

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http://dx.doi.org/10.1007/s11547-019-00989-yDOI Listing
February 2019

New advances in MRI diagnosis of degenerative osteoarthropathy of the peripheral joints.

Radiol Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100, L'Aquila, Italy.

Degenerative osteoarthropathy is one of the leading causes of the pain and disability from musculoskeletal disease in the adult population. Magnetic resonance imaging (MRI) allows optimal visualization of all tissues involved in degenerative osteoarthritis disease process, mainly the articular cartilage. In addition to qualitative and semiquantitative morphologic assessment, several MRI-based advanced techniques have been developed to allow characterization and quantification of the biochemical cartilage composition. Read More

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http://dx.doi.org/10.1007/s11547-019-01003-1DOI Listing
February 2019

Stem Cells from Human Extracted Deciduous Teeth Expanded in Foetal Bovine and Human Sera Express Different Paracrine Factors After Exposure to Freshly Prepared Human Serum.

Adv Exp Med Biol 2019 Feb 16. Epub 2019 Feb 16.

Regenerative Dentistry Research Group, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.

Background: The response of stem cells to paracrine factors within the host's body plays an important role in the regeneration process after transplantation. The aim of this study was to determine the viability and paracrine factor profile of stem cells from human extracted deciduous teeth (SHED) pre-cultivated in media supplemented with either foetal bovine serum (FBS) or pooled human serum (pHS) in the presence of individual human sera (iHS).

Methods: SHED (n = 3) from passage 4 were expanded in FBS (FBS-SHED) or pHS (pHS-SHED) supplemented media until passage 7. Read More

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http://dx.doi.org/10.1007/5584_2018_299DOI Listing
February 2019

Probing Structural Changes in Alpha-Synuclein by Nuclear Magnetic Resonance Spectroscopy.

Methods Mol Biol 2019 ;1948:157-181

Weill Cornell Medicine, New York, NY, USA.

Alpha-synuclein, the principal protein involved in the pathogenesis of Parkinson's disease, has been shown to exchange between multiple conformational states, with hitherto unclear physiological role of such conformational changes. Due to its ability to provide rich structural information for proteins in their near-native environment, nuclear magnetic resonance (NMR) spectroscopy has been a valuable tool to study these conformational states. In this review we describe the application of model systems and NMR methods to the study of membrane-bound states of alpha-synuclein. Read More

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http://dx.doi.org/10.1007/978-1-4939-9124-2_13DOI Listing
January 2019

Pattern of Cerebellar Atrophy in Friedreich's Ataxia-Using the SUIT Template.

Cerebellum 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology and Hertie Institute for Clinical Brain Research, Eberhard Karls University, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

Whole-brain voxel-based morphometry (VBM) studies revealed patterns of patchy atrophy within the cerebellum of Friedreich's ataxia patients, missing clear clinico-anatomic correlations. Studies so far are lacking an appropriate registration to the infratentorial space. To circumvent these limitations, we applied a high-resolution atlas template of the human cerebellum and brainstem (SUIT template) to characterize regional cerebellar atrophy in Friedreich's ataxia (FRDA) on 3-T MRI data. Read More

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http://dx.doi.org/10.1007/s12311-019-1008-zDOI Listing
February 2019

Plaque modification using a cutting balloon is more effective for stenting of heavily calcified lesion than other scoring balloons.

Cardiovasc Interv Ther 2019 Feb 15. Epub 2019 Feb 15.

Division of Cardiology, Fukuoka Red Cross Hospital, 3-1-1 Okusu, Minami-ku, Fukuoka, 815-8555, Japan.

Cutting balloons (CBs) and other scoring balloons are known to be useful for plaque modification in heavily calcified lesions. There have been some reports of the efficacy of these balloons compared to conventional balloons. However, there have been no reports exploring which balloon is most effective among these three types of balloons. Read More

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http://dx.doi.org/10.1007/s12928-019-00578-wDOI Listing
February 2019

Arthroscopic anterior shoulder stabilisation in overhead sport athletes: 5-year follow-up.

Ir J Med Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Trauma & Orthopaedic Surgery, Galway University Hospitals, Galway, Ireland.

Introduction: Shoulder instability following traumatic glenohumeral dislocation is a common injury sustained by athletes particularly in contact and collision sports. Overhead contact sports such as gaelic football and hurling pose a unique hazard to the glenohumeral joint, increasing the risk of dislocation.

Aims: To assess return to sport, level of play, recurrence and functional outcomes in gaelic football and hurling athletes in comparison with players of other sports. Read More

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http://dx.doi.org/10.1007/s11845-019-01986-wDOI Listing
February 2019

Acute multiple sclerosis lesion pathology does not predict subsequent clinical course-a biopsy study.

Ir J Med Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Neuropathology, Beaumont Hospital, Beaumont Road, Dublin, Ireland.

Background: Knowledge of the clinical outcome in tumefactive demyelination remains limited.

Aims: This study aims to characterise the natural history of biopsy-proven, pathogen-free, cerebral demyelination in an adult Irish population.

Methods: We identified all patients with biopsy-proven demyelination in a single neuropathology centre between 1999 and 2017. Read More

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http://dx.doi.org/10.1007/s11845-019-01983-zDOI Listing
February 2019

Impact of the CYP2D6 phenotype on hyperprolactinemia development as an adverse event of treatment with atypical antipsychotic agents in pediatric patients.

Ir J Med Sci 2019 Feb 15. Epub 2019 Feb 15.

Discipline of Medical Genetics, Department of Microscopic Morphology, Victor Babeş University of Medicine and Pharmacy Timișoara, Timișoara, Romania.

Background: Treatment with atypical antipsychotics is today the election therapy for different types of psychosis, but there is a high incidence of endocrine and metabolic disturbances. One of the major enzymes involved in the metabolism of antipsychotics is CYP2D6. Depending on the existing CYP2D6 alleles, the metabolic capacity of the enzyme may vary from very low to very high, so that patients can be grouped into four phenotypic groups: slow, intermediate, extensive (normal), and fast metabolizers. Read More

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http://dx.doi.org/10.1007/s11845-019-01985-xDOI Listing
February 2019

Proteomic and genomic profiling of pancreatic cancer.

Cell Biol Toxicol 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, Clinical Sciences Lund, Skåne University Hospital, Lund University, SE-221 85, Lund, Sweden.

Pancreatic cancer remains the most fatal human tumor type. The aggressive tumor biology coupled with the lack of early detection strategies and effective treatment are major reasons for the poor survival rate. Collaborative research efforts have been devoted to understand pancreatic cancer at the molecular level. Read More

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http://dx.doi.org/10.1007/s10565-019-09465-9DOI Listing
February 2019

Regional pulmonary effects of bronchoalveolar lavage procedure determined by electrical impedance tomography.

Intensive Care Med Exp 2019 Feb 15;7(1):11. Epub 2019 Feb 15.

Pediatric and Neonatal Intensive Care Unit, Children's Hospital, University of Geneva, Geneva, Switzerland.

Background: The provision of guidance in ventilator therapy by continuous monitoring of regional lung ventilation, aeration and respiratory system mechanics is the main clinical benefit of electrical impedance tomography (EIT). A new application was recently described in critically ill patients undergoing diagnostic bronchoalveolar lavage (BAL) with the intention of using EIT to identify the region where sampling was performed. Increased electrical bioimpedance was reported after fluid instillation. Read More

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http://dx.doi.org/10.1186/s40635-019-0225-6DOI Listing
February 2019

Hypocalcemia and hypophosphatemia after treatment with zoledronic acid in a patient with AL amyloidosis.

Intern Emerg Med 2019 Feb 15. Epub 2019 Feb 15.

Regional Reference Centre for Coagulation Disorders, Department of Clinical Medicine and Surgery, "Federico II" University of Naples, Via S. Pansini, 5, 80131, Naples, Italy.

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http://dx.doi.org/10.1007/s11739-019-02048-wDOI Listing
February 2019

Kurzbericht zur Mitgliederbefragung 2018 der Österreichischen Gesellschaft für Innere Medizin.

Authors:
Gert Mayer

Wien Klin Wochenschr 2019 Feb;131(3-4):95-96

Department für Innere Medizin, Univ.-Klinik für Innere Medizin IV (Nephrologoie und Hypertensiologie), Medizinische Universität Innsbruck, Anichstraße 35, 6020, Innsbruck, Österreich.

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http://dx.doi.org/10.1007/s00508-019-1452-2DOI Listing
February 2019

Just choice: a Danielsian analysis of the aims and scope of prenatal screening for fetal abnormalities.

Med Health Care Philos 2019 Feb 15. Epub 2019 Feb 15.

Department of Health, Ethics and Society, GROW School for Oncology and Developmental Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD, Maastricht, The Netherlands.

Developments in Non-Invasive Prenatal Testing (NIPT) and cell-free fetal DNA analysis raise the possibility that antenatal services may soon be able to support couples in non-invasively testing for, and diagnosing, an unprecedented range of genetic disorders and traits coded within their unborn child's genome. Inevitably, this has prompted debate within the bioethics literature about what screening options should be offered to couples for the purpose of reproductive choice. In relation to this problem, the European Society of Human Genetics (ESHG) and American Society of Human Genetics (ASHG) tentatively recommend that any expansion of this type of screening, as facilitated by NIPT, should be limited to serious congenital and childhood disorders. Read More

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http://dx.doi.org/10.1007/s11019-019-09888-5DOI Listing
February 2019

Evidence for personalised medicine: mechanisms, correlation, and new kinds of black box.

Theor Med Bioeth 2019 Feb 15. Epub 2019 Feb 15.

Macquarie University, North Ryde, NSW, Australia.

Personalised medicine (PM) has been discussed as a medical paradigm shift that will improve health while reducing inefficiency and waste. At the same time, it raises new practical, regulatory, and ethical challenges. In this paper, we examine PM strategies epistemologically in order to develop capacities to address these challenges, focusing on a recently proposed strategy for developing patient-specific models from induced pluripotent stem cells (iPSCs) so as to make individualised treatment predictions. Read More

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http://dx.doi.org/10.1007/s11017-019-09482-zDOI Listing
February 2019

Validation of new Japanese classification system for esophageal achalasia.

Esophagus 2019 Feb 15. Epub 2019 Feb 15.

Department of Gastroenterological Surgery, Osaka University, Graduate School of Medicine, 2-2, E-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: The fourth edition of New Japanese classification system for esophageal achalasia was revised after a long interval of 30 years in 2012. In this new system, achalasia is morphologically classified into 3 types, based on its X-ray findings. However, the system has been limitedly used in Japan and has not been fully validated in terms of its predictive capability of postoperative outcomes. Read More

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http://dx.doi.org/10.1007/s10388-019-00658-zDOI Listing
February 2019

Oncologic and reproductive outcomes of cystectomy as a fertility-sparing treatment for early-stage epithelial ovarian cancer.

Int J Clin Oncol 2019 Feb 15. Epub 2019 Feb 15.

Department of Obstetrics and Gynecology, Graduate School of Medicine, Nagoya University, Truma-cho 65, Showa-ku, 466-8550, Nagoya, Japan.

Background: Fertility-sparing surgery (FSS) has mainly been chosen for young women with ovarian-confined/well-differentiated epithelial ovarian cancer (EOC). In general, FSS consists of at least conservation of contralateral ovary and the uterus with a staging surgery. However, information on the clinical outcome in women who underwent cystectomy as a fertility-preserving option is lacking. Read More

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http://dx.doi.org/10.1007/s10147-019-01416-yDOI Listing
February 2019

Imaging of hip and thigh muscle injury: a pictorial review.

Insights Imaging 2019 Feb 15;10(1):20. Epub 2019 Feb 15.

Institute of Diagnostic and Interventional Radiology, Pediatric Radiology and Neuroradiology, University Medical Center Rostock, Ernst-Heydemann-Str. 6, 18057, Rostock, Germany.

Muscle injuries of the hip and thigh are a highly relevant issue in competitive sports imaging. The gold standard in diagnostic imaging of muscle injuries is magnetic resonance imaging (MRI). Radiologists need to be familiar with typical MRI findings in order to accurately detect and classify muscle injuries. Read More

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http://dx.doi.org/10.1186/s13244-019-0702-1DOI Listing
February 2019
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