4,045,890 results match your criteria Med World Chronicle - Omnicare[Journal]


Quercus ilex Extract Ameliorates Acute TNBS-Induced Colitis in Rats.

Planta Med 2019 Apr 24. Epub 2019 Apr 24.

Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain.

L. (Fagaceae) is one of the most commonly used plants in folk medicine in the Mediterranean region to treat gastrointestinal disorders. The aim of the present study was to evaluate the effects of a polyphenol extract from mature leaves of on acute 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats. Read More

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http://dx.doi.org/10.1055/a-0889-6132DOI Listing

Dual-source photon counting detector CT with a tin filter: a phantom study on iodine quantification performance.

Phys Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Mayo Clinic, Rochester, Minnesota, UNITED STATES.

Purpose: Photon counting detectors (PCD) can provide spectral information to enable iodine quantification through multi-energy imaging but performance is limited by current PCD technology. The purpose of this work is to evaluate iodine quantification in a phantom study using dual-source PCD-CT (DS-PCD-CT), and compare to single-source (SS)-PCD-CT and traditional DS energy integrating detector (EID)-based dual-energy CT.
 Materials and Methods: A multi-energy CT phantom with iodine inserts (0 to 15 mg/ml concentration) was imaged on a research SS-PCD-CT scanner (CTDIvol = 18 mGy). Read More

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http://dx.doi.org/10.1088/1361-6560/ab1c34DOI Listing

First clinical retrospective investigation of limited projection CBCT for lung tumor localization in patients receiving SBRT treatment.

Phys Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Department of Radiation Oncology, Duke University Medical Center, PO Box 3295, Durham, NC 27710-3295, USA, Durham, North Carolina, UNITED STATES.

Purpose: To clinically investigate the limited-projection CBCT (LP-CBCT) technology for daily positioning of patients receiving breath-hold lung SBRT radiation treatment and to investigate the feasibility of reconstructing fast 4D-CBCT from 1 min 3D-CBCT scan.
 Method: Eleven patients who underwent breath-hold lung SBRT radiation treatment were scanned daily with on-board full-projection CBCT (CBCT) using half-fan scan. A subset of the CBCT projections and the prior planning CT were used to estimate the LP-CBCT images using the weighted free-form deformation method. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1c0cDOI Listing

Dosimetric impact of esophagus motion in single fraction spine stereotactic body radiotherapy.

Phys Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, UNITED STATES.

Nine patients with single fraction spinal stereotactic body radiation therapy (SBRT) treatment were identified to assess both the intra fraction and daily esophageal motion and associated dosimetric deviation in spinal SBRT. We performed a chained deformable registration of 4-D CT phase images to estimate the intra fraction motion magnitude of the esophagus in a breathing cycle. The intra fraction esophageal motion mostly exhibited in the superior-inferior direction with the total motion magnitude increased from the T1 (0. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1c2bDOI Listing

Biomechanically driven intraoperative spine registration during navigated anterior vertebral body tethering.

Phys Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Ecole Polytechnique de Montreal, Montreal, CANADA.

The integration of pre-operative biomechanical planning with intra-operative imaging for navigated corrective spine surgery may improve surgical outcome, as well as the accuracy and safety of manoeuvres such as pedicle screw insertion and cable tethering, as these steps are performed empirically by the surgeon. However, registration of finite element models (FEM) of the spine remains challenging due to changes in patient positioning and imaging modalities. The purpose of this study was to develop and validate a new method registering a preoperatively constructed patient-specific finite element model (FEM) aimed to plan and assist anterior vertebral body tethering (AVBT) of scoliotic patients, to intraoperative Cone Beam Computed Tomography (CBCT) during navigated AVBT procedures. Read More

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http://iopscience.iop.org/article/10.1088/1361-6560/ab1bfa
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http://dx.doi.org/10.1088/1361-6560/ab1bfaDOI Listing
April 2019
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Performance comparison of depth-encoding detectors based on dual-ended readout and different SiPMs for high-resolution PET applications.

Phys Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Department of Biomedical Engineering, University of California - Davis, One Shields Avenue, Davis, California, 95616, UNITED STATES.

Silicon photomultipliers (SiPMs) are widely used in positron emission tomography (PET), however, SiPMs from different vendors vary in their performance characteristics. In addition, the specifications provided by the manufacturers are measured under different operating conditions and using different test setups, making it difficult to choose the optimal device for a specific application using the published specifications. In this work, we evaluated four state-of-the-art 8 × 8 arrays of ~ 3 mm × 3 mm SiPMs from SensL, KETEK, and Hamamatsu for high-resolution dual-ended readout detectors using the same experimental setup and procedures. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1c37DOI Listing

Emergency medicine board pass rates and medical residents' experiences following the introduction of the small group learning approach in Qatar.

Int J Med Educ 2019 Apr 24;10:88-89. Epub 2019 Apr 24.

Department of Emergency medicine, Hamad General Hospital, Doha, Qatar.

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http://dx.doi.org/10.5116/ijme.5cb2.e936DOI Listing

Strategy focused on clinical parameters of microcirculation to resuscitate patients in septic shock: do not forget any tools.

Anaesth Crit Care Pain Med 2019 Apr 21. Epub 2019 Apr 21.

Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.

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http://dx.doi.org/10.1016/j.accpm.2019.04.009DOI Listing

Neurotoxicity of anaesthetics on developing brain: a relevant question or just a "bias"?

Anaesth Crit Care Pain Med 2019 Apr 21. Epub 2019 Apr 21.

Department of Neonatology and Paediatric Intensive Care, Charles Nicolle University Hospital, 1, rue de Germont, F-76031 Rouen Cedex. France.

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http://dx.doi.org/10.1016/j.accpm.2019.04.005DOI Listing

Implications of the mitochondrial interactome of mammalian thioredoxin 2 for normal cellular function and disease.

Free Radic Biol Med 2019 Apr 21. Epub 2019 Apr 21.

Department of Chemistry, University of Patras, Rion 26504, Greece. Electronic address:

Multiple thioredoxin isoforms exist in all living cells. To explore the possible functions of mammalian mitochondrial thioredoxin 2 (Trx2), an interactome of mouse Trx2 was initially created using (i) a monothiol mouse Trx2 species for capturing protein partners from different organs and (ii) yeast two hybrid screens on human liver and rat brain cDNA libraries. The resulting interactome consisted of 195 proteins (Trx2 included) plus the mitochondrial 16S RNA. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.018DOI Listing

Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFRα in Adult Brain.

Cell Rep 2019 Apr;27(4):1073-1089.e5

Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan. Electronic address:

Oligodendrocyte progenitor cells (OPCs) are widely distributed cells of ramified morphology in adult brain that express PDGFRα and NG2. They retain mitotic activities in adulthood and contribute to oligodendrogenesis and myelin turnover; however, the regulatory mechanisms of their cell dynamics in adult brain largely remain unknown. Here, we found that global Pdgfra inactivation in adult mice rapidly led to elimination of OPCs due to synchronous maturation toward oligodendrocytes. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.084DOI Listing

Molecular aspects of signalling in diabesity.

Mol Aspects Med 2019 Apr 21. Epub 2019 Apr 21.

Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2019.04.003DOI Listing

The retinoic acid receptor (RAR) α-specific agonist Am80 (tamibarotene) and other RAR agonists potently inhibit hepatitis B virus transcription from cccDNA.

Antiviral Res 2019 Apr 21. Epub 2019 Apr 21.

University Hospital Heidelberg (Germany), Center for Infectious Diseases, Molecular Virology, Germany; German Center for Infection Research (DZIF), Partner Site Heidelberg, TTU Hepatitis, Germany. Electronic address:

Chronic infection with the human Hepatitis B virus (HBV) is a major global health problem. Hepatitis D virus (HDV) is a satellite of HBV that uses HBV envelope proteins for cell egress and entry. Using infection systems encoding the HBV/HDV receptor human sodium taurocholate co-transporting polypeptide (NTCP), we screened 1181 FDA-approved drugs applying markers for interference for HBV and HDV infection. Read More

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http://dx.doi.org/10.1016/j.antiviral.2019.04.009DOI Listing

The Genetics and Epigenetics of Facioscapulohumeral Muscular Dystrophy.

Annu Rev Genomics Hum Genet 2019 Apr 24. Epub 2019 Apr 24.

Department of Pharmacology, School of Medicine, University of Nevada, Reno, Nevada 89557, USA; email:

Facioscapulohumeral muscular dystrophy (FSHD), a progressive myopathy that afflicts individuals of all ages, provides a powerful model of the complex interplay between genetic and epigenetic mechanisms of chromatin regulation. FSHD is caused by dysregulation of a macrosatellite repeat, either by contraction of the repeat or by mutations in silencing proteins. Both cases lead to chromatin relaxation and, in the context of a permissive allele, aberrant expression of the gene in skeletal muscle. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-genom-0831
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http://dx.doi.org/10.1146/annurev-genom-083118-014933DOI Listing
April 2019
1 Read

The Imperative for Climate Action to Protect Health.

Authors:
Charles M Bagley

N Engl J Med 2019 Apr;380(17):e29

1235 8th Ave. W., Seattle, WA.

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http://dx.doi.org/10.1056/NEJMc1902963DOI Listing

The Imperative for Climate Action to Protect Health.

N Engl J Med 2019 Apr;380(17):e29

MGH Institute of Health Professions, Boston, MA.

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http://dx.doi.org/10.1056/NEJMc1902963DOI Listing

Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer. Reply.

N Engl J Med 2019 Apr;380(17):e28

Université de Lille, Lille, France

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http://dx.doi.org/10.1056/NEJMc1901650DOI Listing

Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer.

N Engl J Med 2019 Apr;380(17):e28

University of Athens Medical School, Athens, Greece.

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http://dx.doi.org/10.1056/NEJMc1901650DOI Listing

Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer.

N Engl J Med 2019 Apr;380(17):e28

Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom

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http://dx.doi.org/10.1056/NEJMc1901650DOI Listing

Ibrutinib Regimens in Older Patients with Untreated CLL. Reply.

N Engl J Med 2019 Apr;380(17):1680-1681

Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1056/NEJMc1901284DOI Listing

Ibrutinib Regimens in Older Patients with Untreated CLL.

N Engl J Med 2019 Apr;380(17):1679-1681

Catholic University of Leuven, Leuven, Belgium

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http://dx.doi.org/10.1056/NEJMc1901284DOI Listing

Ibrutinib Regimens in Older Patients with Untreated CLL.

N Engl J Med 2019 Apr;380(17):1679

Tata Memorial Centre, Mumbai, India.

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http://dx.doi.org/10.1056/NEJMc1901284DOI Listing

Ibrutinib Regimens in Older Patients with Untreated CLL.

Authors:
Omer Diker

N Engl J Med 2019 Apr;380(17):1679

Near East University Hospital, Nicosia, Cyprus

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http://dx.doi.org/10.1056/NEJMc1901284DOI Listing

Cardiovascular Risk Reduction with Icosapent Ethyl. Reply.

N Engl J Med 2019 Apr;380(17):1678

University of Maryland School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1056/NEJMc1902165DOI Listing

Cardiovascular Risk Reduction with Icosapent Ethyl.

N Engl J Med 2019 Apr;380(17):1678

University of Bologna, Bologna, Italy

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http://dx.doi.org/10.1056/NEJMc1902165DOI Listing

Cardiovascular Risk Reduction with Icosapent Ethyl.

N Engl J Med 2019 Apr;380(17):1677

University of Washington School of Pharmacy, Seattle, WA

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http://dx.doi.org/10.1056/NEJMc1902165DOI Listing

Stomaching Drug Delivery.

N Engl J Med 2019 Apr;380(17):1671-1673

From the School of Veterinary Medicine and Conway Institute of Biotechnology, University College Dublin, Dublin.

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http://dx.doi.org/10.1056/NEJMcibr1901766DOI Listing

Case 13-2019: A 54-Year-Old Man with Alcohol Withdrawal and Altered Mental Status.

N Engl J Med 2019 Apr;380(17):1657-1665

From the Departments of Medicine (A.Z.F.), Radiology (A.M.), Psychiatry (M.N.), and Pathology (L.R.M.), Massachusetts General Hospital, and the Departments of Medicine (A.Z.F.), Radiology (A.M.), Psychiatry (M.N.), and Pathology (L.R.M.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1900591DOI Listing

Hydroxychloroquine Retinal Toxicity.

N Engl J Med 2019 Apr;380(17):e27

Haverhill, MA.

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http://dx.doi.org/10.1056/NEJMicm1304542DOI Listing

Bull's-Eye Maculopathy Associated with Hydroxychloroquine.

N Engl J Med 2019 Apr;380(17):1656

Cole Eye Institute, Cleveland, OH

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http://dx.doi.org/10.1056/NEJMicm1412167DOI Listing

Hazardous Chemical Emergencies and Poisonings.

N Engl J Med 2019 Apr;380(17):1638-1655

From the Division of Emergency Medicine and Poison Control Center, Children's Hospital of Philadelphia, and the Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (F.M.H.); the Department of Homeland Security, Washington, DC (M.A.K.); and the Division of Medical Toxicology, Department of Emergency Medicine, University of Connecticut Health Center and Hartford Hospital, Hartford (C.A.M.).

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http://dx.doi.org/10.1056/NEJMra1504690DOI Listing

Tagraxofusp in Blastic Plasmacytoid Dendritic-Cell Neoplasm.

N Engl J Med 2019 Apr;380(17):1628-1637

From the University of Texas M.D. Anderson Cancer Center, Houston (N.P., M.D., H.M.K., M.K.); Dana-Farber Cancer Institute (A.A.L.) and Boston University School of Medicine (J.M.S.), Boston, and Veristat, Southborough (J.B.) - all in Massachusetts; H. Lee Moffitt Cancer Center, Tampa, FL (K.L.S., J.E.L.); City of Hope National Medical Center, Duarte, CA (A.S.S.); Ohio State University, Columbus (S.V.); Winship Cancer Institute of Emory University, Atlanta (W.B.); Duke University Medical Center, Durham, NC (D.A.R.); and Roswell Park Comprehensive Cancer Center, Buffalo (E.S.W.), and Stemline Therapeutics, New York (S. Spence, S. Shemesh, C.L.B., I.B.) - both in New York.

Background: Blastic plasmacytoid dendritic-cell neoplasm (BPDCN) is an aggressive hematologic cancer that is caused by transformed plasmacytoid dendritic cells that overexpress interleukin-3 receptor subunit alpha (IL3RA or CD123). Tagraxofusp (SL-401) is a CD123-directed cytotoxin consisting of human interleukin-3 fused to truncated diphtheria toxin.

Methods: In this open-label, multicohort study, we assigned 47 patients with untreated or relapsed BPDCN to receive an intravenous infusion of tagraxofusp at a dose of 7 μg or 12 μg per kilogram of body weight on days 1 to 5 of each 21-day cycle. Read More

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http://dx.doi.org/10.1056/NEJMoa1815105DOI Listing

The ROC Curve Redefined - Optimizing Sensitivity (and Specificity) to the Lived Reality of Cancer.

Authors:
Susan P Walker

N Engl J Med 2019 Apr;380(17):1594-1595

From the Department of Obstetrics and Gynaecology, University of Melbourne; and Mercy Hospital for Women - both in Melbourne, Australia.

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http://dx.doi.org/10.1056/NEJMp1814951DOI Listing

The VA MISSION Act - Creating a Center for Innovation within the VA.

N Engl J Med 2019 Apr;380(17):1592-1594

From the VA Puget Sound Healthcare System (A.R.) and the Department of Medicine, University of Washington School of Medicine (A.R., SDF., J.M.L.) - both in Seattle; and the Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia (J.M.L.).

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http://dx.doi.org/10.1056/NEJMp1815209DOI Listing

No Shortcuts to Safer Opioid Prescribing.

N Engl J Med 2019 Apr 24. Epub 2019 Apr 24.

From the Centers for Disease Control and Prevention, Atlanta (D.D., T.H.); and Oregon Health and Science University, Portland (R.C.).

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http://dx.doi.org/10.1056/NEJMp1904190DOI Listing

A Temporizing Solution to "Artemisinin Resistance".

N Engl J Med 2019 Apr 24. Epub 2019 Apr 24.

From the Artemisinin Research Center and the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing (J.W., C.X., F.L.L., T.J., Y.T.), and the ShenZhen People's Hospital, ShenZhen (J.W., C.X.) - both in China; the Department of Pharmacology and Biological Sciences, National University of Singapore, Singapore (J.W., C.X.); the Centre for Diagnostics and Antimicrobial Resistance, Institute for Infection and Immunity, St. George's University of London and St. George's University Hospitals NHS Foundation Trust, London (S.K.); and the Institut für Tropenmedizin, Universitätsklinikum Tübingen, Tübingen, Germany (S.K.).

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http://dx.doi.org/10.1056/NEJMp1901233DOI Listing

Quality Focus: Disease Prevention: Immunization Opportunity to Reduce Disease Burden.

S D Med 2019 Mar;72(3):140

South Dakota Foundation for Medical Care.

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Facing the Fluoroquinolone Facts: Safety Concerns Continue to Emerge.

Authors:
Stacy Peters

S D Med 2019 Mar;72(3):136-138

College of Pharmacy and Allied Health Professions, South Dakota State University.

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Elders in Lakota Culture: Reflections from Pine Ridge.

S D Med 2019 Mar;72(3):134

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

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A Reflection on Acquiring Cultural Awareness.

S D Med 2019 Mar;72(3):132-133

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

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Cultural Immersion Isn't About Diabetes: Understanding the Lakota Sioux Culture on the Pine Ridge Indian Reservation.

Authors:
Ali Haines

S D Med 2019 Mar;72(3):131-132

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

This article discusses the historical trauma and modern struggles of Oglala Lakota Sioux tribal members on the Pine Ridge Indian Reservation in southwestern South Dakota. In order for healthcare providers to understand why patients from this region have soaring rates of diabetes, teen pregnancies and premature death, it is important to have exposure to their culture and daily life. As part of their medical school curriculum, students at the Sanford School of Medicine take part in cultural immersion trips in order to better understand and relate to the people on the Pine Ridge Reservation. Read More

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Pine Ridge Retreat Center.

S D Med 2019 Mar;72(3):128-130

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

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Pine Ridge Experience.

S D Med 2019 Mar;72(3):127-128

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

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American Indian Ethics of Health Care When Serving American Indian Patients in South Dakota.

S D Med 2019 Mar;72(3):123-126

Department of Neurosciences, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

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Lifelong Learning Reflections on Relations.

Authors:
Donovan Williams

S D Med 2019 Mar;72(3):120-121

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

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The Patient As Team: American Indian Healthcare and the Transorganization - A Shout for Leadership.

S D Med 2019 Mar;72(3):114-118

Sanford Clinic - Infectious Disease, Sioux Falls, South Dakota.

American Indian health care in the state of South Dakota meets the definition of a humanitarian crisis and as such is being called a third-world country within its own borders. This dizzying challenge will require an out-ofthe-box but previously successful Transorganization, to address a problem which will never be solved by separate organizations operating in silos. It will also require visionary leadership to shine a permanent light on this conundrum, inviting all physicians and healthcare systems to join together as a team of teams, until this situation is transformed. Read More

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Bilateral Papillitis and Anterior Uveitis in a Pediatric Patient.

S D Med 2019 Mar;72(3):110-113

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

We report a case of bilateral papillitis and anterior uveitis in a pediatric patient with preceding viral prodrome. Because this is a rare disease in the pediatric population, work-up in this case was extensive given the wide differential of papilledema in the pediatric setting. The clinical significance of this case is to bring to light the timely recognition, follow-up, and treatment of this disease to minimize the burden to the patient and family. Read More

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Perceived Weight Status, Disease Risk and Weight Loss Among Young Adults.

S D Med 2019 Mar;72(3):102-108

Health and Nutritional Sciences Department, South Dakota State University.

Introduction: Accurate perception of overweight status can influence weight management practices and may contribute to perceived risk of weight-related diseases. Understanding how weight perception impacts weight management and perceived risks in young adults is important, as it is during this time that individuals are forming lifestyle behaviors and likely not burdened by chronic disease.

Methods: Cross-sectional data from 86 young adults (18-25 years) were analyzed. Read More

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A Great Opportunity to Look at Developing a Collaborated Care System.

Authors:
Donovan Williams

S D Med 2019 Mar;72(3):100

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

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Endoscopic Robot-Assisted Simple Enucleation of Renal Tumours: Impact of Learning Curve and Tumour Complexity on Trifecta Outcomes.

Int J Med Robot 2019 Apr 24:e2000. Epub 2019 Apr 24.

Department of Urology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.

Background: In this article, we report the outcomes of endoscopic robot-assisted tumour enucleation (ERASE) using a trifecta system.

Methods: 182 patients were treated with ERASE by a single surgeon between October 2014 and February 2017 and were stratified by quartiles of distribution called ERASE eras 1-4, and PADUA-score risk group categories. The trifecta achievement rates in different ERASE eras and PADUA-score risk group categories were analysed. Read More

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http://dx.doi.org/10.1002/rcs.2000DOI Listing
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