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Int J Gynaecol Obstet 2022 May 22. Epub 2022 May 22.

Department of Obstetrics and Gynecology, Soroka University Medical Center, School of Medicine, Ben Gurion University of the Negev, Beer Sheva, Israel.

Objective: To assess the correlation between total Area Under the Curve (AUC) of decelerations and accelerations and neonatal acidemia in pregnancies complicated with meconium-stained amniotic fluid (MSAF).

Methods: A retrospective cohort study was conducted among women who delivered with a diagnosis of MSAF. Electronic fetal monitoring (EFM) patterns 120 minutes before delivery were interpreted by a researcher blinded to fetal outcomes. Read More

Int J Gynaecol Obstet 2022 May 22. Epub 2022 May 22.

The Unit of Plastic Surgery, Carmel Medical Center, Haifa, Israel.

Objective: To identify risk factors associated with accidental fetal skin lacerations (AFL) during cesarean section (CS).

Methods: This retrospective cohort study was obtained from registry of two large medical centers between 2014-2019. The study group was comprised of all newborns identified with AFL. Read More

Arch Gynecol Obstet 2022 May 21. Epub 2022 May 21.

Division of Obstetrics and Prenatal Medicine, Department of Medicine and Surgery (DIMEC), IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy, University of Bologna, Via Massarenti 13, 40138, Bologna, Italy.

Purpose: The aim of the study was to determine the cause-specific hazard (CSH) and the cumulative incidence function (CIF) for umbilical cord metabolic acidemia at birth (MA; pH < 7.0 and/or BE [Formula: see text] - 12 mmol/L) at delivery in patients experiencing the 2nd stage of labor (2STG), stratified for both FIGO-2015 pathologic intrapartum cardiotocography requiring expedited delivery (CTG_RED) and duration of 2nd stage of labor.

Methods: 3459 pregnancies experiencing the 2nd stage of labor and delivering at the Division of Obstetrics and Prenatal Medicine, IRCCS Sant'Orsola-Malpighi Hospital, Bologna (Italy), were identified between 2018 and 2019. Read More

Cureus 2022 Apr 12;14(4):e24057. Epub 2022 Apr 12.

Pediatric Surgery, The Children's Hospital and University of Child Health Sciences, Lahore, PAK.

Background and objective Intestinal perforations and necrotizing enterocolitis (NEC) requiring the formation of temporary intestinal stoma are prevalent conditions worldwide. This prospective study aimed to address the following research question: does sutureless enterostomy lead to fewer complications compared to conventional enterostomy in critically sick surgical neonates who need a stoma? Methods We conducted a randomized control trial (TCTR20211011004) from October 2020 to October 2021. A total of 120 patients were randomized to the following two study groups: Group A: conventional sutured enterostomy; Group B: sutureless enterostomy, with 60 patients in each group. Read More

Int J Pediatr Adolesc Med 2022 Mar 22;9(1):32-35. Epub 2021 Mar 22.

College of Medicine, AlFaisal University, Riyadh, Saudi Arabia.

Introduction: Meconium ileus (MI) is one of the most common causes of intestinal obstruction in newborns. It is the earliest clinical manifestation of cystic fibrosis (CF). MI is suspected if a baby fails to pass meconium shortly after birth and develops symptoms of bowel obstruction, such as distention of the abdomen or vomiting. Read More

Ceylon Med J 2021 Jun;66(2):77-86

Academic Obstetrics and Gynaecology Unit, Teaching Hospital Mahamodara, Galle, Sri Lanka,

Aims: To assess the feasibility of administration of three doses of oral misoprostol (OM) 50 µg four hourly per day for 48 hours versus the insertion of a supra cervical Foley catheter for 48 hours, in women at 40 weeks + 5 days gestation, and compare the effectiveness of the two methods for induction of labour (IOL).

Method: An investigator blinded, randomized controlled trial was conducted at the academic obstetric unit, Teaching Hospital Mahamodara, Galle from 13.10. Read More

J Clin Med 2022 Apr 30;11(9). Epub 2022 Apr 30.

The Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv 6997801, Israel.

COVID-19 infection imposes a risk for pregnant individuals and may lead to adverse maternal and obstetric outcomes. This is a retrospective cohort study of all women giving birth between March and July 2021 at a single tertiary center. Obstetric and neonatal outcomes were compared between vaccinated and non-vaccinated pregnant women with singleton pregnancies. Read More

BMC Pediatr 2022 May 13;22(1):280. Epub 2022 May 13.

School of Public Health, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia.

Background: Birth asphyxia is the inability of a newborn to start and conserve breathing immediately after birth. Globally, 2.5 million infants die within their first month of life every year, contributing nearly 47% of all deaths of children. Read More

Birth 2022 May 13. Epub 2022 May 13.

Department of Obstetrics and Gynecology, Sheba Medical Center, Ramat-Gan, Israel.

Background: Transition of clear amniotic fluid to meconium-stained fluid is a relatively common occurrence during labor. However, data regarding the clinical significance and the prognostic value of the presence of meconium-stained amnionic fluid (MSAF) are scarce. This study aimed to investigate delivery and neonatal outcomes according to the presence of MSAF and the timing of the meconium passage. Read More

Arch Dis Child Fetal Neonatal Ed 2022 May 11. Epub 2022 May 11.

Embrace Transport Service, Sheffield Childrens' Hospital NHS Foundation Trust, Barnsley, UK.

Objective: To assess the impact of public health measures taken during the COVID-19 pandemic on perinatal health indicators.

Design: Interrupted time series analysis comparing periods of the pandemic with the previous 5 years.

Setting: Yorkshire and the Humber region, England (2015-2020). Read More

Psychoneuroendocrinology 2022 Apr 30;142:105787. Epub 2022 Apr 30.

Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai 200032, China.

Background: Maternal emotional symptoms during pregnancy increase the risk of neurodevelopmental problems in offspring, and microbiota have been shown to be a potential mechanism underlying the link. However, the associations among maternal prenatal emotional symptoms, the meconium microbiota, and offspring neurodevelopment have yet to be fully elucidated. The aim of this prospective cohort study was to assess the relationship between maternal prenatal emotional symptoms and neurodevelopment of the child at 24 months of age, and to investigate the potential role of the neonatal meconium microbiota in the relationship. Read More

BMC Pediatr 2022 05 3;22(1):247. Epub 2022 May 3.

University Hospital Leuven, Herestraat 49, 3001, Leuven, Belgium.

Background: This case report describes a child born with both cystic fibrosis (CF) and alpha-1 antitrypsin deficiency (A1ATD). Both are autosomal recessive inherited diseases, mainly affecting the lungs and the liver. The combination of both diseases together is rare and may lead to a fulminant disease with limited life span. Read More

Front Pediatr 2022 15;10:858476. Epub 2022 Apr 15.

Department of Pediatrics, Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, FL, United States.

A cellular proliferation to milk allergens has been found in the cord blood cells of neonates. While this reflects a sensitivity during the fetal life, its clinical significance and disease, particularly its unconventional presentations, have remained largely unrecognized by care providers. Here, we report three cases of infants whose mothers consumed dairy products during pregnancy, who developed a severely constipated pre- and postnatal bowel. Read More

Comput Struct Biotechnol J 2022 2;20:1778-1784. Epub 2022 Apr 2.

Division of Neonatology, Longgang District Central Hospital of Shenzhen, Guangdong 518116, China.

Background: The gut microbiota plays an important role in the early stages of human life. Our previous study showed that the abundance of intestinal flora involved in galactose metabolism was altered and correlated with increased serum bilirubin levels in children with jaundice. We conducted the present study to systematically evaluate alterations in the meconium metabolome of neonates with jaundice and search for metabolic markers associated with neonatal jaundice. Read More

Cureus 2022 Mar 24;14(3):e23458. Epub 2022 Mar 24.

Pediatric Surgery, The Children's Hospital and University of Child Health Sciences, Lahore, PAK.

Background Anatomical abnormalities leading to bowel movement failure are the major cause of intestinal obstruction. This study was done to assess the diagnostic efficacy of contrast enema in neonates with lower intestinal obstruction. Methodology This prospective study was conducted in The Children's Hospital and University of Child Health Sciences, Lahore from February 2021 to July 2021. Read More

J Affect Disord 2022 Apr 28;310:60-67. Epub 2022 Apr 28.

The Japan Drug Information Institute in Pregnancy, National Center for Child Health and Development, Japan; Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Japan.

Background: Depression during pregnancy is relatively undertreated; however, the relationship between prenatal exposure to antidepressants and neonatal outcomes remains controversial.

Methods: This retrospective cohort study used a Japanese nationwide claims database. Data of 114,359 singletons born between January 2005 and November 2019 were used to evaluate the relationship between prenatal exposure to antidepressants and neonatal morbidity. Read More

J Pediatr Surg 2022 Apr 5. Epub 2022 Apr 5.

Department of Pediatric Surgery, Faculty of Medicine, Dokuz Eylül University, Balcova, Izmir 35340, Turkey.

In Vivo 2022 May-Jun;36(3):1285-1289

Department of Obstetrics and Gynecology, University Hospital Cologne and Medical Faculty, Cologne, Germany.

Background/aim: Labor is induced in 1 out of 5 pregnancies. This is why we aimed to compare two different protocols of orally administered misoprostol for the induction of labor (IOL), with special regard to maternal and fetal outcome, delivery mode and duration.

Patients And Methods: One hundred and twenty four patients with a medical indication for IOL were divided into two groups: Group A (n=63), which initially received 50 μg misoprostol escalated to 100 and, subsequently, to 200 μg every 4 h with a daily maximum of 600μg, between 11/2007 and 01/2008; and Group B (n=61), which initially received 25 μg misoprostol followed by 100 μg every 4 h with a daily maximum of 300 μg, between 12/2009 and 04/2010. Read More

Diagnostics (Basel) 2022 Apr 1;12(4). Epub 2022 Apr 1.

Department of Neonatology, Aretaieion University Hospital, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, Greece.

The aim of this systematic review and meta-analysis is the comparison of endotracheal intubation and suctioning to immediate resuscitation without intubation of non-vigorous infants > 34 weeks' gestation delivered through meconium-stained amniotic fluid (MSAF). Randomized, non-randomized clinical trials and observational studies were included. Data sources were PubMed/Medline and Cochrane Central Registry of Controlled Trials, from 2012 to 2021. Read More

Front Pediatr 2022 5;10:828089. Epub 2022 Apr 5.

Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, United States.

Background: The small number of studies examining the association of prenatal acetaminophen with birth outcomes have all relied on maternal self-report. It remains unknown whether prenatal acetaminophen exposure measured in a biological specimen is associated with birth outcomes.

Objectives: To investigate the association of acetaminophen measured in meconium with birthweight, gestational age, preterm birth, size for gestational age, gestational diabetes, preeclampsia, and high blood pressure. Read More

BMC Pregnancy Childbirth 2022 Apr 21;22(1):344. Epub 2022 Apr 21.

Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe St, Baltimore, MD, 21205, USA.

Background: Most existing evidence about the prevalence of prenatal cannabis use relies on self-reported measures, which is limited by social desirability bias and recall bias. To date, several studies have examined the validity of self-reported measures of prenatal cannabis use, but this evidence has yet to be synthesized. To address this gap, we performed a scoping review to systematically identify and synthesize existing evidence on the validity of self-reported measures of cannabis use among pregnant women. Read More

Niger J Clin Pract 2022 Apr;25(4):406-414

Department of Obstetrics and Gynaecology, Bayero University, Kano, Nigeria.

Background: Postdate pregnancy is a very common obstetric condition, increasing the risk of perinatal morbidity and mortality from uteroplacental insufficiency.

Aim: To determine the predictive values of Doppler cerebroplacental ratio (CPR), that is, the ratio between middle cerebral artery (MCA) and UA pulsatility indices (UA PI), and other potential velocimetric predictors of adverse perinatal outcomes in women with postdated pregnancies.

Patients And Methods: A prospective cohort study was conducted on consenting 212 low-risk pregnant women beyond 40 weeks' gestational age. Read More

Int J Surg Case Rep 2022 May 10;94:107065. Epub 2022 Apr 10.

Department of Nursing, Neyshabur University of Medical Sciences, Neyshabur, Iran.

Introduction And Importance: Vertical transmission of the novel coronavirus, known as severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has not yet been proven. However, several case reports and case series worldwide, including ours, support this certain type of transmission. Although COVID-19 has been mostly treated supportively, in some cases, including ours, medical treatment seems to be essential. Read More

J Cyst Fibros 2022 Apr 11. Epub 2022 Apr 11.

Medical University of South Carolina, Charleston, SC 29424, USA.

We report elexacaftor-tezacaftor-ivacaftor (ETI) treatment of a F508del carrier who was pregnant with a F508del homozygous fetus. At 23-weeks gestation meconium ileus (MI) was evident on ultrasound including dilated, hyperechoic bowel, which persisted on subsequent imaging. Through shared decision-making, the mother began ETI at 32 weeks with intent to treat fetal MI. Read More

BJOG 2022 Apr 12. Epub 2022 Apr 12.

The Fetal Medicine Centre, Birmingham Women's and Children's Foundation Trust, Edgbaston, Birmingham, UK.

Aim: To construct evidence-based algorithms for the assessment and management of common amniotic fluid abnormalities detected during labour.

Population: Low-risk singleton, term pregnant women in labour.

Setting: Birth facilities in low- and middle-income countries. Read More

Biol Reprod 2022 Apr 12. Epub 2022 Apr 12.

Department of Animal and Veterinary Science, University of Wyoming, Laramie, WY, 82071.

An analysis of sites within the maternal reproductive microbiome that potentially contribute to fetal gut microbial colonization, with a special focus on the comparison between humans and cattle. Read More

Nagoya J Med Sci 2022 Feb;84(1):148-154

Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

We reviewed the outcomes of meconium peritonitis and evaluated the safety and feasibility of primary radical surgery for meconium peritonitis. A total of 21 cases of meconium peritonitis between 2006 and 2020 were retrospectively reviewed. The patients were classified into two groups based on the type of surgery: group I (primary radical surgery, n = 16) and group II (multistage surgery; drainage only or ileostomy, followed by elective surgery, n = 5). Read More

Front Pediatr 2022 16;10:784439. Epub 2022 Mar 16.

Nuffield Department of Women's and Reproductive Health, Big Data Institute, University of Oxford, Oxford, United Kingdom.

Objective: The role of cardiotocography (CTG) in fetal risk assessment around the beginning of term labor is controversial. We used routinely collected clinical data in a large tertiary hospital to investigate whether infants with "severe compromise" at birth exhibited fetal heart rate abnormalities in their first-hour CTGs and/or other clinical risks, recorded as per routine care.

Materials And Methods: Retrospective data from 27,927 parturitions (single UK tertiary site, 2001-2010) were analyzed. Read More

J Obstet Gynaecol Res 2022 Apr 1. Epub 2022 Apr 1.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Aim: To explore the expression of neuropeptide Y (NPY) and bioinformatics characteristics of intrahepatic cholestasis of pregnancy (ICP).

Methods: Gene chip data of intrahepatic cholestasis of pregnancy were searched from the GEO database with bioinformatics method, and GSE46157 gene chip was downloaded. Differentially expressed genes in normal pregnant placenta tissue and ICP pregnant placenta tissue (bile acid concentration > 40 μmol/L) were screened by GEO2R. Read More

Pediatr Infect Dis J 2022 06 6;41(6):466-472. Epub 2022 May 6.

Grupo de Investigación en Infectología Pediátrica, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.

Background: The vertical transmission of severe acute respiratory coronavirus-2 (SARS-CoV-2) remains highly debated. Here, we evaluated SARS-CoV-2-transmission in newborns with intrauterine conditions.

Methods: This was a prospective, observational and multicentric study involving 13 Spanish hospitals included in the GEStational and NEOnatal-COVID cohort. Read More