4,642 results match your criteria Meckel Diverticulum Imaging


Pre-season Fitness Level and Injury Rate in Professional Soccer - A Prospective Study.

Sports Med Int Open 2018 Jun 22;2(3):E84-E90. Epub 2018 Aug 22.

Child Health & Sports Center, Meir Medical Center, Pediatrics, Sackler School of Medicine, Tel Aviv University Kfar Saba, Israel.

The aim of the present study was to assess prospectively the effect of pre-season fitness on injury rate during the competitive season among professional soccer players. Thirty-one players participated in the study during two consecutive competitive seasons (2015-16 and 2016-17; a squad of 22 players in each season). During the 6-week pre-season training period (8 training sessions and a friendly match every week, 14-18 training hours/week) there was a significant improvement in VO max, a significant increase in ideal and total sprint time and no change in vertical jump, flexibility and repeated sprint-test performance decrement. Read More

View Article

Bleeding Meckel Diverticulum: A Retrospective Analysis of Computed Tomography Enterography Findings.

J Comput Assist Tomogr 2018 Dec 10. Epub 2018 Dec 10.

Department of Radiology, Suzhou Hospital, Nanjing Medical University, Suzhou.

Objective: The aim of this study was to evaluate the computed tomography enterography (CTE) characteristics of bleeding Meckel diverticulum.

Methods: The CTE images of 35 patients with Meckel diverticulum and gastrointestinal bleeding were retrospectively evaluated.

Results: Meckel diverticulum was visualized in 33 of 35 patients and located in the right lower abdomen (20/33), midline lower abdomen (8/33), left lower abdomen (3/33), or paramedially near the umbilicus (2/33). Read More

View Article
December 2018

Trigeminal Neuralgia Caused by Dural Arteriovenous Fistula in Meckel Cave Treated with Gamma Knife Radiosurgery: A Case Report.

World Neurosurg 2018 Nov 27. Epub 2018 Nov 27.

Department of Radiology, Mayo Clinic, 4500 San Pablo Road S, Jacksonville, Florida, USA, 32224; Department of Neurologic Surgery, Mayo Clinic, Jacksonville, FL, USA, 4500 San Pablo Road S, Jacksonville, Florida, USA. Electronic address:

Background: Classic trigeminal neuralgia is an often debilitating condition that frequently results from vascular compression at the root entry zone of the trigeminal nerve. Here, the authors report a case of dural arteriovenous fistula surrounding the trigeminal nerve from near the root entry zone extending as far ventral as Meckel cave treated solely with Gamma Knife radiosurgery.

Case Description: A 71-year-old woman presented with a history of persistent attacks of right facial pain after failed conservative management. Read More

View Article
November 2018
5 Reads

Endovascular stroke treatment's impact on malignant type of edema (ESTIMATE).

J Neurol 2018 Nov 23. Epub 2018 Nov 23.

Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.

Background And Purpose: In patients with acute ischemic stroke and large vessel occlusion, the prognosis has improved tremendously since the implementation of endovascular thrombectomy (EVT). The effect of EVT on the incidence of malignant middle cerebral artery infarctions (MMI) has not been studied before.

Methods: ESTIMATE, a multicenter retrospective study, evaluates data of ischemic stroke patients with occlusion in the anterior circulation in the years of 2007-2015 comparing three treatment options (no therapy; IV-TPA; IV-TPA plus EVT or EVT only). Read More

View Article
November 2018
3 Reads

Combined Transpetrosal Approach With Preservation of Superior Petrosal Vein Drainage for a Cerebellopontine Angle Epidermoid Cyst Extending Into Meckel's Cave: 3-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Nov 18. Epub 2018 Nov 18.

Department of Neurosurgery, Tokyo Medical University, Tokyo, Japan.

The combined transpetrosal approach enables wide exposure around the petroclival region by cutting the tentorium and superior petrosal sinus. We often choose this approach for removal of tumors ventral to the facial and vestibulocochlear nerves, such as petroclival meningioma and epidermoid cyst, because complete removal of the tumor under direct visualization is required to prevent its later recurrence, especially in young patients. Recent reports revealed anatomical variations of the drainage of the superior petrosal sinus, and dural incision considering preservation of the superior petrosal vein was proposed. Read More

View Article
November 2018

Inverted Meckel´s diverticulum: a rare cause of ileo-ileal intussusceptions and lower gastrointestinal bleeding.

Rozhl Chir 2018 ;97(8):399-401

Intussusception due to an inverted Meckel's diverticulum in adults is rare. We present a case report of a 28-year-old man with Meckel's diverticulum as a cause of ileo-ileal intussusceptions and lower gastrointestinal bleeding. The patient was admitted to the hospital with incomplete small bowel obstruction, abdominal pain and massive rectal bleeding. Read More

View Article
January 2018
1 Read

Coupling activation of pro-apoptotic caspases with autophagy in the Meckel´s cartilage.

Physiol Res 2018 Oct 23. Epub 2018 Oct 23.

Department of Physiology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.

Mammalian Meckel´s cartilage is a temporary structure associated with mandible development. Notably, its elimination is not executed by apoptosis, and autophagy was suggested as the major mechanism. Simultaneous reports point to pro-apoptotic caspases as novel participants in autophagic pathways in general. Read More

View Article
October 2018
4 Reads

Axial Mesodermal Dysplasia Complex with a Unique Abnormal Course of Vestibulocochlear Nerve.

J Int Adv Otol 2018 Nov 15. Epub 2018 Nov 15.

Department of Radiology, Mersin University School of Medicine, Mersin, Turkey.

Axial mesodermal dysplasia complex (AMDC) is a combination of multiple congenital malformations arising due to the mesodermal cell migration, neural tube fusion, and rhombencephalon segmentation. Here, we present the imaging findings of a 15-year-old boy with AMDC who has bilateral inner ear malformations associated with a vestibulocochlear nerve extending to Meckel cave, cystic lesion in prepontine cisterna, cervical vertebral segmentation anomalies, and maxillar bone anomalies. Read More

View Article
November 2018
3 Reads

Isolated Horner syndrome as a rare initial presentation of nasopharyngeal carcinoma: a case report.

Int Med Case Rep J 2018 18;11:271-276. Epub 2018 Oct 18.

Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand,

Background: Horner syndrome refers to a set of clinical presentations resulting from disruption of sympathetic innervation to the eye and adnexa. Classically, the clinical triad consists of ipsilateral blepharoptosis, pupillary miosis, and facial anhidrosis. Ocular sympathetic denervation may signify life-threatening causes. Read More

View Article
October 2018
1 Read

Spontaneous perforation and intraabdominal abscess due to Meckel's diverticulum revealed on SPECT/CT with 99m-technetium pertechnetate: A case report.

Medicine (Baltimore) 2018 Oct;97(43):e13004

The Department of Nuclear Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Rationale: Meckel's diverticulum (MD) is common congenital abnormality of gastrointestinal tract, only about 6.4% of patients become symptomatic. A smaller minority develop potential fatal complications such as hemorrhage, perforation, abscess, and bowel obstruction. Read More

View Article
October 2018
4 Reads

Light-controlled chemoenzymatic immobilization of proteins towards engineering of bioactive papers.

Chemistry 2018 Nov 5. Epub 2018 Nov 5.

Clemens-Schoepf-Institute for Organic Chemistry and Biochemistry Technical University Darmstadt, Biochemistry, Alarich-Weiss-Strasse 4, 64287, Darmstadt, GERMANY.

Efficient and reliable methods for the generation of bioactive papers are of growing interest in view of point-of-care testing devices that do not require extensive analytical equipment. Herein, we report on immobilization of functional proteins onto paper fibers using a modular chemoenzymatic approach. The synthetic strategy relies on the combination of highly efficient spatially controllable photo-triggered cycloaddition followed by site-specific sortase A-catalyzed transamidation. Read More

View Article
November 2018

A rare complication in a liver transplant patient: Meckel diverticulum perforation due to biliary stent.

Int J Surg Case Rep 2018 Oct 4;53:35-38. Epub 2018 Oct 4.

Cukurova University, Department of General Surgery, Adana, Turkey.

Introduction: Meckel's diverticulum is the most common congenital lesion of the small intestine. The incidence varies between 0.5% and 2% Biliary stents can be used for the treatment of patients with bile duct complications. Read More

View Article
October 2018
4 Reads

Intraflagellar Transport Complex A Genes Differentially Regulate Cilium Formation and Transition Zone Gating.

Curr Biol 2018 Oct 4;28(20):3279-3287.e2. Epub 2018 Oct 4.

UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address:

Cilia are found on most eukaryotic cell types, serving motility, environment sensing, and signaling (cell-cell) functions, and defects cause genetic diseases (ciliopathies), affecting the development of many tissues [1]. Cilia are built by intraflagellar transport (IFT), a bidirectional microtubule-based motility driven by kinesin-2 anterograde (toward ciliary tip) and IFT-dynein retrograde (toward ciliary base) motors together with IFT-A and IFT-B cargo adaptor complexes that control retrograde and anterograde IFT, respectively [2]. Ciliary composition is also facilitated by the transition zone (TZ) at the ciliary base and the associated Meckel-Gruber syndrome (MKS) and nephronophthisis (NPHP) modules that establish protein diffusion barriers and regulate cilium structure [3]. Read More

View Article
October 2018

Tectonic Proteins Are Important Players in Non-Motile Ciliopathies.

Cell Physiol Biochem 2018 4;50(1):398-409. Epub 2018 Oct 4.

Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, China.

Primary cilium is a ubiquitous, tiny organelle on the apex of the mammalian cells. Non-motile (primary) ciliopathies are diseases caused by the dysfunction of the primary cilium and they are characterized by diverse clinical and genetic heterogeneity. To date, nearly 200 genes have been shown to be associated with primary ciliopathies. Read More

View Article
November 2018
3 Reads

Whole exome sequencing resolves complex phenotype and identifies CC2D2A mutations underlying non-syndromic rod-cone dystrophy.

Clin Genet 2018 Sep 29. Epub 2018 Sep 29.

Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France.

Genetic investigations were performed in three brothers from a consanguineous union, the two oldest diagnosed with rod-cone dystrophy (RCD), the youngest with early-onset cone-rod dystrophy and the two youngest with nephrotic-range proteinuria. Targeted next-generation sequencing did not identify homozygous pathogenic variant in the oldest brother. Whole exome sequencing (WES) applied to the family identified compound heterozygous variants in CC2D2A (c. Read More

View Article
September 2018
1 Read

Meckel's Cave Meningiomas: New Classification System Focalized on Dumbbell Lesions Deriving from the Morphometric Analysis of the Posterior Petrous Apicectomy on Fresh Non-Formalin-Fixed Specimens. A Correlative Anatomoclinical Study.

World Neurosurg 2018 Oct 6;118:e489-e499. Epub 2018 Jul 6.

Chair of Bari University Medical School, Bari, Italy.

Background: The Meckel's cave (MC) is commonly affected by neoplastic lesions that often require neurosurgical treatment. We simulated the posterior petrous apicectomy (PPA) on fresh cadavers to verify the in vivo feasibility of the approach. We proposed a new classification system of MC meningioma based on the extent of middle cranial fossa (MCF) involvement. Read More

View Article
October 2018
2 Reads

Complicated Meckel's diverticulum: Presentation modes in adults.

Medicine (Baltimore) 2018 Sep;97(38):e12457

Digestive Surgery Unit, European Georges Pompidou University AP-HP Hospital.

Complicated Meckel's diverticulum represents a common etiology of acute abdomen in children. However, this condition is less frequent in adults. We reviewed the records of adult patients who underwent the surgical removal of complicated Meckel's diverticulum between 2001 and 2017 at 2 tertiary French medical centers. Read More

View Article
September 2018
5 Reads
5.720 Impact Factor

Meckel's Diverticulum in Adults: Surgical Concerns.

Front Surg 2018 3;5:55. Epub 2018 Sep 3.

Department of General Surgery, General Hospital of Drama, Drama, Greece.

Since Meckel's diverticulum (MD) is rarely diagnosed in adults, there is no consensus on what type of procedure to be performed for symptomatic MD and whether to resect or not an accidentally discovered MD. Treatment of symptomatic MD is definitive surgery, including diverticulectomy, wedge, and segmental resection. The type of procedure depends on: (a) the integrity of diverticulum base and adjacent ileum; (b) the presence and location of ectopic tissue within MD. Read More

View Article
September 2018
1 Read

[Divertículo de Meckel con tejido pancreático ectópico en un niño de 12 años con invaginación intestinal. Reporte de caso y revisión de la literatura].

Cir Cir 2018 ;86(5):450-454

División de Investigación Clínica. Hospital General Dr. Manuel Gea González, Ciudad de México, México.

Introducción: El divertículo de Meckel es un remanente del conducto onfalomesentérico y su prevalencia es del 2%.

Caso Clínico: Niño de 12 años con dolor abdominal, acompañado de evacuaciones mucosanguinolentas y hematemesis, con masa en cuadrante inferior derecho. En la laparotomía quirúrgica se encontró invaginación, y se realizó desinvaginación y resección del divertículo de Meckel. Read More

View Article
January 2018
1 Read

[Meckel's diverticulum : state of the art].

Rev Med Liege 2018 Sep;73(9):474-479

Service de Pédiatrie, CHA Libramont, Belgique.

The persistence of the embryonic vitelline duct can lead to omphalomesenteric duct anomalies. A wide variety of anomalies, depending on the remnant segment and its degree of involution, may occur as a result of the omphalomesenteric duct failing to obliterate completely. The most frequent omphalomesenteric duct anomaly is Meckel's diverticulum, which is present in approximately 2-3 % of the population. Read More

View Article
September 2018
1 Read

The Coexistence of a Horseshoe Kidney and Meckel Diverticulum With Dramatic Mobility Revealed Through 99mTc Pertechnetate Imaging.

Clin Nucl Med 2018 Nov;43(11):825-827

From the Department of Nuclear Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China.

A previously healthy 11-year-old boy with intermittent abdominal pain and bloody stool underwent Meckel scintigraphy. On the initial images, there was a faint U-shaped activity in the mid-abdominal region, which gradually faded and evolved into distinct foci of radiotracer accumulation in the later images. One of the foci changed its location during the study, suspected as moving Meckel diverticulum. Read More

View Article
November 2018
2 Reads

Systematic review of epidemiology, presentation, and management of Meckel's diverticulum in the 21st century.

Medicine (Baltimore) 2018 Aug;97(35):e12154

Department of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger.

Background: The contemporary demographics and prevalence of Meckel's diverticulum, clinical presentation and management is not well described. Thus, this article aims to review the recent literature concerning Meckel's diverticulum.

Methods: A systematic PubMed/Medline database search using the terms "Meckel" and "Meckel's" combined with "diverticulum. Read More

View Article
August 2018
1 Read

The interval-training paradox: Physiological responses vs. subjective rate of perceived exertion.

Physiol Behav 2018 Nov 25;196:144-149. Epub 2018 Aug 25.

Life Science Department, The Academic College at Wingate, Wingate Institute, Israel.

Objective: The purpose of the present study was to compare the physiological and perceived exertion responses of two different interval-training protocols - decreasing- and increasing-distance, matched for total distance, throughout a six-week training period.

Methods: Forty male physical education students (23 ± 1.3 years) were randomly assigned to either the increasing- or decreasing-distance interval-training group (ITG and DTG). Read More

View Article
November 2018

Meckel's Diverticulum in Crohn's Disease Revisited: A Case of Meckel's Diverticulitis in a Patient with Stricturing Crohn's Disease.

Cureus 2018 Jun 22;10(6):e2865. Epub 2018 Jun 22.

Gastroenterology, Creighton University, Omaha, USA.

According to anecdotal reports in literature, encountering Meckel's diverticulum in a patient with Crohn's disease is not uncommon, but differentiating between the overlapping complications of Mickel's diverticulum and the natural manifestations of Crohn's disease can be challenging and may impact lifelong therapy. In this report, we present a case of Meckel's diverticulitis in a patient with stricturing ileocolonic Crohn's disease. A 29-year-old male has been suffering from recurrent bouts of abdominal pain and diarrhea which were initially thought to be due to recurrent flares of Crohn's disease. Read More

View Article
June 2018
1 Read

Mks6 mutations reveal tissue- and cell type-specific roles for the cilia transition zone.

FASEB J 2018 Aug 22:fj201801149R. Epub 2018 Aug 22.

Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

The transition zone (TZ) is a domain at the base of the cilium that is involved in maintaining ciliary compartment-specific sensory and signaling activity by regulating cilia protein composition. Mutations in TZ proteins result in cilia dysfunction, often causing pleiotropic effects observed in a group of human diseases classified as ciliopathies. The purpose of this study is to describe the importance of the TZ component Meckel-Grüber syndrome 6 ( Mks6) in several organ systems and tissues regarding ciliogenesis and cilia maintenance using congenital and conditional mutant mouse models. Read More

View Article
August 2018
15 Reads

Imaging Workup of Acute and Occult Lower Gastrointestinal Bleeding.

Radiol Clin North Am 2018 Sep;56(5):791-804

Boston University Medical Center, 830 Harrison Avenue, FGH 3rd Floor, Boston, MA 02118, USA. Electronic address:

Lower gastrointestinal bleeding is defined as occurring distal to the ligament of Treitz and presents as hematochezia, melena, or with anemia and positive fecal occult blood test. Imaging plays a pivotal role in the localization and treatment of lower gastrointestinal bleeds. Imaging tests in the workup of acute lower gastrointestinal bleeding include computed tomography (CT) angiography, nuclear medicine scintigraphy, and conventional catheter angiography. Read More

View Article
September 2018
3 Reads

Unique case of trigeminal neuralgia due to Epstein-Barr-virus-associated B-cell lymphomatoid granulomatosis of the Meckel's cave and cavernous sinus: Important clinical and therapeutic implications.

Surg Neurol Int 2018 26;9:148. Epub 2018 Jul 26.

Department of Neurosurgery, Mainz University Hospital, Langenbeckstraße 1, 55131 Mainz, Germany.

Background: Trigeminal neuralgia (TN) represents one of the most disabling pain syndromes. Several diseases have been described as etiological triggers of TN, vascular compression of the trigeminal nerve being the most frequent cause. Here, we describe for the first time a rare case of TN caused by an infiltration of an isolated Epstein-Barr virus (EBV) B-cell lymphomatoid granulomatosis (LYG) mass into the Meckel's cave and cavernous sinus. Read More

View Article
July 2018
3 Reads

Spelunking Meckel Cave: A 31-Year-Old With Diplopia and Loss of Taste and Smell.

Chest 2018 Aug;154(2):e45-e48

Department of Internal Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, CA.

Case Presentation: A 31-year-old woman presented to the ED with a loss of taste and smell of 2 months' duration and a frontal headache, bilateral facial numbness, photophobia, and horizontal diplopia that was worse with far vision of 2 weeks' duration. A review of systems revealed mild nausea and decreased appetite without weight loss. She denied any cardiopulmonary symptoms, specifically no cough or shortness of breath. Read More

View Article
August 2018
2 Reads

Sporadic Burkitt's lymphoma masquerading as an intussuscepted Meckel's diverticulum in a 9-year-old child.

BMJ Case Rep 2018 Jul 24;2018. Epub 2018 Jul 24.

Pathology, Gold Coast University Hospital, Southport, Queensland, Australia.

We report the case of a 9-year-old boy who presented with abdominal pain and was found to have an intussusception with a sporadic Burkitt's lymphoma (BL) lead point. Our case was unusual in that the patient did not present with the typical clinical features of BL, nor was he in a high-risk demographic for this uncommon disease. Read More

View Article
July 2018
1 Read

Ulcerative colitis in an infant aged 20 months. A case report.

Arch Argent Pediatr 2018 Aug;116(4):e599-e602

Department of Pediatrics, Allergology and Gastroenterology CM Bydgoszcz, NCU Torun, Poland.

Bloody diarrhea is a common problem in early childhood, typically caused by anal fissures, infectious enteritis, allergic proctocolitis, swallowed maternal blood and intussusception. More rarely, it can also be caused by volvulus, coagulopathies, necrotizing enterocolitis, polyps, Meckel diverticulitis and inflammatory bowel disease (IBD). The incidence of IBD is on the rise in children, even affecting infants. Read More

View Article
August 2018
10 Reads

A Spectrum of Entities That May Mimic Abdominopelvic Abscesses Requiring Image-guided Drainage.

Radiographics 2018 Jul-Aug;38(4):1264-1281

From the Department of Radiology, Virginia Commonwealth University Medical Center, 1250 E Marshall St, PO Box 980615, Richmond, VA 23298.

A variety of entities may mimic drainable abscesses. This can lead to misdiagnosis of these entities, unnecessary percutaneous placement of a pigtail drainage catheter, other complications, and delay in appropriate treatment of the patient. Types of entities that may mimic drainable abscesses include neoplasms (lymphoma, gallbladder cancer, gastrointestinal stromal tumor, ovarian cancer, mesenteric fibromatosis, ruptured mature cystic teratoma, recurrent malignancy in a surgical bed), ischemia/infarction (liquefactive infarction of the spleen, infarcted splenule), diverticula (calyceal, Meckel, and giant colonic diverticula), and congenital variants (obstructed duplicated collecting system). Read More

View Article
October 2018
14 Reads

Imaging-Ambiguous Lesions of Meckel's Cave-Utility of Endoscopic Endonasal Transpterygoid Biopsy.

World Neurosurg 2018 Oct 30;118:e346-e355. Epub 2018 Jun 30.

Pacific Neuroscience Institute, John Wayne Cancer Institute, Providence Saint John's Health Center, Santa Monica, California, USA. Electronic address:

Introduction: Meckel's cave is a dural-lined cavity in the middle fossa skull base in which lies the Gasserian ganglion, a potential site for tumors and inflammatory lesions. A variety of lesions can be predominantly isolated to Meckel's cave, including extension from head and neck cancers, other malignant tumors, as well as benign lesions. Clinical presentation and imaging findings are often insufficient to establish a diagnosis. Read More

View Article
October 2018
4 Reads

Fourth down and five.

Surv Ophthalmol 2018 Jun 28. Epub 2018 Jun 28.

Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, Utah, USA; Department of Neurology, University of Utah, Salt Lake City, Utah, USA.

Binocular diplopia and right hemifacial numbness developed in a 52-year-old woman after resection of a right temporal lobe glioblastoma. Based on the Parks-Bielschowsky 3-step test, she was diagnosed with a right cranial nerve (CN) IV palsy in addition to right CN V dysfunction. Iatrogenic diplopia may result from temporal lobe surgery due to the intimate relationship of CN IV and CN III to the mesial temporal lobe. Read More

View Article
June 2018
7 Reads

TeleNEN as a telemedicine model for neuroendocrine neoplasm management in case of Meckel's diverticulum NET.

Endokrynol Pol 2018 ;69(3):313-317

Nuclear Medicine Department, Medical University of Warsaw, Warsaw, Poland.

A case of 25- years-old female with NET deriving from Meckel's diverticulum is described. The patient had one year history of dermatological skin problems. Ultrasound examination of abdomen performed because of arterial hypertension, revealed multiple hepatic lesions, which was confirmed in contrast enhanced CT. Read More

View Article
October 2018
3 Reads

Generation of Potent Anti-HER1/2 Immunotoxins by Protein Ligation Using Split Inteins.

ACS Chem Biol 2018 Aug 3;13(8):2058-2066. Epub 2018 Jul 3.

Institute for Organic Chemistry and Biochemistry , Technische Universität Darmstadt , Alarich-Weiss-Strasse 4 , D-64287 Darmstadt , Germany.

Cell targeting protein toxins have gained increasing interest for cancer therapy aimed at increasing the therapeutic window and reducing systemic toxicity. Because recombinant expression of immunotoxins consisting of a receptor-binding and a cell-killing moiety is hampered by their high toxicity in a eukaryotic production host, most applications rely on recombinant production of fusion proteins consisting of an antibody fragment and a protein toxin in bacterial hosts such as Escherichia coli ( E. coli). Read More

View Article
August 2018
2 Reads

Seasonal Variations in Physical Fitness and Performance Indices of Elite Soccer Players.

Sports (Basel) 2018 Feb 13;6(1). Epub 2018 Feb 13.

The Academic College at Wingate, Wingate Institute, Netanya 4290200, Israel.

The aim of the study was to investigate seasonal variations in fitness and performance indices of professional male soccer players. Eighteen professional male soccer players (age range 22⁻32 years) completed three similar sets of tests at three stages of the season: before preseason; after preseason and the middle of the competitive in-season. A significant decrease in body mass and percent fat was found during the preseason. Read More

View Article
February 2018
2 Reads

Meckel's diverticulum leiomyoma presenting as a mobile abdominal mass.

Diagn Interv Imaging 2018 Nov 14;99(11):769-771. Epub 2018 Jun 14.

Department of Radiology, Centre Hospitalier Universitaire, Pôle d'imagerie, 47, rue Cognacq-Jay, 51092 Reims cedex, France.

View Article
November 2018
6 Reads

Meckel's diverticulum-associated small bowel obstruction after appendectomy.

Pediatr Int 2018 May;60(5):494-496

Department of Pediatric Surgery, Takamatsu Red Cross Hospital, Takamatsu, Kagawa, Japan.

View Article
May 2018
2 Reads

[Complicated Meckel diverticula: about 15 cases].

Pan Afr Med J 2018 29;29:81. Epub 2018 Jan 29.

Service de Chirurgie Générale, CHU Aristide Le Dantec, Dakar, Sénégal.

We conducted a retrospective study of 15 patients with complicated Meckel diverticula treated in the emergency surgery at the Aristide Le Dantec Hospital, Dakar, over a period of 13 years (January 2003-June 2016). The study included 10 men and 5 women, whose average age was 27.8 years, ranging between 1 months and 73 years. Read More

View Article
June 2018
2 Reads

Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening.

Biophys J 2018 Jul 1;115(2):263-275. Epub 2018 Jun 1.

Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan; Genome and Systems Biology Degree Program, National Taiwan University, Taipei, Taiwan. Electronic address:

The primary cilium is an essential organelle mediating key signaling activities, such as sonic hedgehog signaling. The molecular composition of the ciliary compartment is distinct from that of the cytosol, with the transition zone (TZ) gated the ciliary base. The TZ is a packed and organized protein complex containing multiple ciliopathy-associated protein species. Read More

View Article

Giant Meckel's Diverticulum.

J Gastrointest Surg 2018 May 29. Epub 2018 May 29.

Colorectal Unit, Department of Surgery, Grenoble Alps University Hospital, 38000, Grenoble, France.

View Article
May 2018
11 Reads

[Intussusception followed by intestinal obstruction in adults].

Khirurgiia (Mosk) 2018(5):40-44

Martynov Chair of Hospital-Based Surgery # 1, Sechenov First Moscow State Medical University of Healthcare Ministry of the Russian Federation, Vorokhobov Municipal City Clinical Hospital No. 67 Moscow Healthcare Department, Moscow, Russia.

Aim: To evaluate the effectiveness of complex preoperative diagnostics and medication of intussusception followed by intestinal obstruction in adults with the choice of surgical repair and analysis of the outcomes depending on the causes of intussusception.

Material And Methods: 15 intussusception patients aged 19 - 86 years were enrolled. Mean age was 52. Read More

View Article
October 2018
2 Reads

Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis.

Inflamm Bowel Dis 2018 Jun;24(7):1471-1480

Department of Medicine, Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago Medicine, Chicago, IL, United States.

Background And Aims: Mucosal appearance on endoscopy is an important indicator of inflammatory burden and determines prognosis in ulcerative colitis (UC). Inflammation induces tryptophan metabolism along the kynurenine pathway (KP) and yields immunologically relevant metabolites. We sought to examine whether changes in serum tryptophan metabolites and tissue expression of KP enzymes are associated with UC endoscopic and histologic disease severity. Read More

View Article
June 2018
7 Reads
4.460 Impact Factor

Heterotopic pancreas without Meckel's diverticulum in children as unique cause of gastrointestinal bleeding: think about it!

Surg Radiol Anat 2018 Aug 21;40(8):963-965. Epub 2018 May 21.

Service de Chirurgie Infantile, Hôpital de la Timone, 13005, Marseille Cedex 20, France.

Ectopic pancreas also known as heterotopic pancreas (HP) is a rare congenital anomaly, mainly found as incidental finding during autopsy or abdominal exploration for an other condition. Incidence rate is probably underestimated as patients are mostly asymptomatic; otherwise, it is capable of producing symptoms depending on its location, size, often appearing in the 4th-to-6th decades. Complications such as inflammation, obstruction, bleeding, and malignancy degeneration must be considered. Read More

View Article
August 2018
4 Reads

Basal exon skipping and nonsense-associated altered splicing allows bypassing complete CEP290 loss-of-function in individuals with unusually mild retinal disease.

Hum Mol Genet 2018 May 16. Epub 2018 May 16.

Laboratory of Genetics in Ophthalmology (LGO), INSERM UMR1163, Institute of Genetics Diseases, Imagine and Paris Descartes University, 75015 Paris, France.

CEP290 mutations cause a spectrum of ciliopathies from Leber congenital amaurosis type 10 (LCA10) to embryo-lethal Meckel syndrome (MKS). Using panel-based molecular diagnosis testing for inherited retinal diseases, we identified two individuals with some preserved vision despite biallelism for presumably truncating CEP290 mutations. The first one carried a homozygous 1 base-pair deletion in exon 17, introducing a premature termination codon (PTC) in exon 18 (c. Read More

View Article
May 2018
4 Reads

Unique presentation of a ruptured Meckel's diverticulum after blunt trauma.

BMJ Case Rep 2018 May 16;2018. Epub 2018 May 16.

Department of Surgery, NYU Langone Hospital - Brooklyn, Brooklyn, New York, USA.

View Article
May 2018
2 Reads

Ionizing Radiation Induces Morphological Changes and Immunological Modulation of Jurkat Cells.

Front Immunol 2018 30;9:922. Epub 2018 Apr 30.

Department of Biology, Membrane Biophysics, Technische Universität Darmstadt, Darmstadt, Germany.

Impairment or stimulation of the immune system by ionizing radiation (IR) impacts on immune surveillance of tumor cells and non-malignant cells and can either foster therapy response or side effects/toxicities of radiation therapy. For a better understanding of the mechanisms by which IR modulates T-cell activation and alters functional properties of these immune cells, we exposed human immortalized Jurkat cells and peripheral blood lymphocytes (PBL) to X-ray doses between 0.1 and 5 Gy. Read More

View Article
April 2018
21 Reads