4,736 results match your criteria Mechanisms of Ageing and Development [Journal]


Oxidative stress-induced senescence markedly increases disc cell bioenergetics.

Mech Ageing Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Orthopedic Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, 15213, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Electronic address:

Cellular senescence is a phenotype characterized by irreversible growth arrest, chronic elevated secretion of proinflammatory cytokines and matrix proteases, a phenomenon known as senescence associated secretory phenotype (SASP). Biomarkers of cellular senescence have been shown to increase with age and degeneration of human disc tissue. Senescent disc cells in culture recapitulate features associated with age-related disc degeneration, including increased secretion of proinflammatory cytokines, matrix proteases, and fragmentation of matrix proteins. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00476374183019
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http://dx.doi.org/10.1016/j.mad.2019.04.006DOI Listing
April 2019
6 Reads

Frailty biomarkers in humans and rodents: current approaches and future advances.

Mech Ageing Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA; Department of Pharmacology, The University of New South Wales, Sydney, Australia. Electronic address:

Even though they would have great benefit across research and clinical fields, currently there are no accepted biomarkers of frailty. Cross-sectional studies in humans have identified promising candidates including inflammatory markers such as IL-6, immune markers such as WBC count, clinical markers such as albumin, endocrine markers such as vitamin D, oxidative stress markers such as isoprostanes, proteins such as BDNF and epigenetic markers such as DNA methylation, but there are limitations to the current state of the research. Future approaches to the identification of frailty biomarkers should include longitudinal studies, studies using animal models of frailty, studies incorporating novel biomarkers combined into composite panels, and studies investigating sex differences and potential overlap between markers of biological age and frailty. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00476374193003
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http://dx.doi.org/10.1016/j.mad.2019.03.007DOI Listing
April 2019
1 Read

AGE-RELATED DEFICIT ACCUMULATION AND THE DISEASES OF AGEING.

Mech Ageing Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.

With ageing, the potency of individual risk factors traditionally associated with common illnesses declines. Instead, it is becoming clear that the impact of a wide range of age-related deficits not traditionally considered as risk factors for these illnesses increases. These age-related deficits chiefly confer risk as a group, not individually. Read More

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http://dx.doi.org/10.1016/j.mad.2019.04.005DOI Listing
April 2019
1 Read

Prioritized brain selenium retention and selenoprotein expression: Nutritional insights into Parkinson's disease.

Mech Ageing Dev 2019 Apr 15;180:89-96. Epub 2019 Apr 15.

Department of Geriatrics and Neurology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou, Zhejiang, China; Department of Preventive Medicine, School of Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:

Selenium (Se), an essential trace mineral, confers its physiological functions mainly through selenoproteins, most of which are oxidoreductases. Results from animal, epidemiological, and human genetic studies link Parkinson's disease to Se and certain selenoproteins. Parkinson's disease is characterized by multiple motor and non-motor symptoms that are difficult to diagnose at early stages of the pathogenesis. Read More

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http://dx.doi.org/10.1016/j.mad.2019.04.004DOI Listing
April 2019
4 Reads

Modulation of frailty syndrome by diet: A review of evidence from mouse studies.

Mech Ageing Dev 2019 Apr 10;180:82-88. Epub 2019 Apr 10.

Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, 02115, USA.

Frailty is a progressive, aging-related syndrome of unknown etiology characterized by increased susceptibility and decreased resilience to external stressors. Understanding underlying mechanisms and identifying interventions to improve resilience are major challenges in biogerontology. Adequate nutrition is central to organismal health and wellbeing and can be modulated to improve longevity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00476374193004
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http://dx.doi.org/10.1016/j.mad.2019.04.003DOI Listing
April 2019
3 Reads

Astragaloside IV and ferulic acid synergistically promote neurite outgrowth through Nrf2 activation.

Mech Ageing Dev 2019 Apr 10;180:70-81. Epub 2019 Apr 10.

The Institute of Medicine, Qiqihar Medical University, Qiqihar 161006, China. Electronic address:

Recently, nuclear factor (erythroid-derived 2)-like 2 (Nrf2) have nuclear localization and nuclear exclusion signals and shuttle between the cytoplasm and the nucleus. Thus, we hypothesised that astragaloside IV (AS-IV) induction nuclear import of Nrf2 and ferulic acid (FA) inhibition nuclear export of Nrf2 contribute to synergistic antioxidant effects of combination of FA and AS-IV (FA/AS-IV). Here, we have demonstrated that FA/AS-IV enhances neurite outgrowth of PC12 cells challenged with lead acetate (PbAc) via antioxidant properties in a synergistic manner. Read More

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http://dx.doi.org/10.1016/j.mad.2019.04.002DOI Listing
April 2019
3 Reads

Sublethal whole-body irradiation causes progressive premature frailty in mice.

Mech Ageing Dev 2019 Apr 4;180:63-69. Epub 2019 Apr 4.

Newcastle University Institute for Ageing and Institute for Cell and Molecular Biology, Campus for Ageing and Vitality, Newcastle University, Newcastle Upon Tyne, NE4 5PL, UK. Electronic address:

There is an unmet need to develop and validate therapies that can treat or at least prevent premature therapy-induced frailty, multi-morbidity and mortality in long-term tumour survivors. In an approach to develop a first mouse model for therapy-induced long-term frailty, we irradiated male C57Bl/6 mice at 5-6 months of age sub-lethally with 3 × 3 Gy (whole body) and assessed subsequent frailty for up to 6 months using a Rockwood-type frailty index (FI). Frailty scorers were trained to obtain excellent inter- and intra-observer reproducibility. Read More

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http://dx.doi.org/10.1016/j.mad.2019.03.006DOI Listing
April 2019
5 Reads

High intensity interval training improves physical performance in aged female mice: A comparison of mouse frailty assessment tools.

Mech Ageing Dev 2019 Apr 2;180:49-62. Epub 2019 Apr 2.

Division of Geriatrics and Palliative Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo and Research Service, Veterans Affairs Western New York Healthcare System, Buffalo, NY, USA.

Frailty syndrome increases the risk for disability and mortality, and is a major health concern amidst the geriatric shift in the population. High intensity interval training (HIIT), which couples bursts of vigorous activity interspersed with active recovery intervals, shows promise for the treatment of frailty. Here we compare and contrast five Fried physical phenotype and one deficit accumulation based mouse frailty assessment tools for identifying the impacts of HIIT on frailty and predicting functional capacity, underlying pathology, and survival in aged female mice. Read More

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http://dx.doi.org/10.1016/j.mad.2019.04.001DOI Listing
April 2019
1 Read

Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions.

Mech Ageing Dev 2019 Mar 26;180:42-48. Epub 2019 Mar 26.

Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Electronic address:

Although survival has been the focus of aging research for many years, the field is rapidly evolving towards incorporating healthspan and health indices in studies that explore aging-related outcomes. Frailty is one such measure that is tightly correlated with human aging. Several frailty measures have been developed that focus on phenotypes of aging, including physical, cognitive and metabolic health that define healthspan. Read More

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http://dx.doi.org/10.1016/j.mad.2019.03.005DOI Listing
March 2019
3 Reads

The impact of physical activity and sedentary behaviors on frailty levels.

Mech Ageing Dev 2019 Mar 26;180:29-41. Epub 2019 Mar 26.

Department of Medicine, Dalhousie University, Halifax, NS, Canada.

Heterogeneity in aging can be explained by frailty. Lifestyle behaviors such as physical activity can help manage frailty levels. Conversely, sedentary behaviours are associated with frailty independently of physical activity. Read More

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http://dx.doi.org/10.1016/j.mad.2019.03.004DOI Listing

Age and frailty as risk factors for the development of osteoarthritis.

Mech Ageing Dev 2019 Mar 18;180:21-28. Epub 2019 Mar 18.

Departments of Pharmacology and Anaesthesia, Pain Management & Perioperative Medicine, Dalhousie University, 5850 College Street, Halifax, Nova Scotia, B3H 4R2, Canada. Electronic address:

Osteoarthritis (OA) is a degenerative joint disease that increases in prevalence with advanced age. While a multitude of factors contribute to the development of OA, ageing has been implicated as a major driving force leading to an inability of the joint to repair itself and maintain normal health. In aged individuals, changes in joint cellular composition and signalling mechanisms have been observed which could lead to the development of degenerative joint disease. Read More

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http://dx.doi.org/10.1016/j.mad.2019.03.003DOI Listing
March 2019
3 Reads

Geroprotectors: A role in the treatment of frailty.

Mech Ageing Dev 2019 Mar 15;180:11-20. Epub 2019 Mar 15.

MRC Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing, University of Sheffield, UK. Electronic address:

The proportion of the population over the age of 65 is growing the most rapidly due to the longevity revolution. Frailty is prevalent in this age group and strongly associated with disability and hospitalization, having a significant impact on the costs of health and social care. New effective interventions to delay or reverse frailty are urgently required. Read More

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http://dx.doi.org/10.1016/j.mad.2019.03.002DOI Listing

Circulating miR-146a in healthy aging and type 2 diabetes: Age- and gender-specific trajectories.

Mech Ageing Dev 2019 Mar 14;180:1-10. Epub 2019 Mar 14.

Department of Clinical and Molecular Sciences, DISCLIMO, Università Politecnica delle Marche, Ancona, Italy; Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy.

To evaluate the combined effect of age and glycemic state on circulating levels of the inflamma-miR-146a levels, 188 healthy subjects (CTR) aged 20-104 years and 144 type-2 diabetic patients (T2DM), aged 40-80 years, were analyzed. In CTR subjects, miR-146a levels showed a significant age-related decline. When a gender-stratified analysis was ran, the miR-146a age-related trajectory was confirmed only in men and a negative correlation with PAI-1, uric acid, and creatinine was also observed. Read More

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http://dx.doi.org/10.1016/j.mad.2019.03.001DOI Listing
March 2019
2 Reads

Do sex differences in chronic disease underpin the sex-frailty paradox?

Mech Ageing Dev 2019 04 27;179:44-50. Epub 2019 Feb 27.

Centre for Health Services Research, Level 2, Building 33, Princess Alexandra Hospital, 199 Ipswich Road, Woolloongabba, QLD, 4102, Australia.

The 'male-female health-survival paradox' is a well-described clinical phenomenon. More recently, it has been conceptualized as a 'sex-frailty paradox': females may be considered to be more frail (because they have poorer health status) but also less frail (because they are less vulnerable to death) than males of the same age. Here, we review potential biological, behavioral and social mechanisms underpinning sex differences in morbidity, mortality and frailty before considering the question at the center of the sex paradox - why is it that females are able to tolerate poor health better than males? We explore, in detail, a frequently cited explanation for the sex paradox that centers on sex differences in chronic disease and conclude by presenting a new approach to this old hypothesis. Read More

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http://dx.doi.org/10.1016/j.mad.2019.02.004DOI Listing
April 2019
1 Read

Functional genomics of dietary restriction and longevity in yeast.

Mech Ageing Dev 2019 04 18;179:36-43. Epub 2019 Feb 18.

Unidad de Genómica Avanzada (Langebio), Centro de Investigación y de Estudios Avanzados del IPN, 36824, Irapuato, Guanajuato, Mexico. Electronic address:

Dietary restriction-limitation of calories or other specific nutrients in the diet-is the sole non-genetic intervention known to extend the lifespan of a wide range of model organisms from yeast to mammals. Cell biology studies on the responses to dietary restriction have provided important clues about the mechanisms of longevity; however, a comprehensive genome-wide description of lifespan by dietary restriction has been mostly absent. Large-scale genetic analysis in the budding yeast Saccharomyces cerevisiae offers a great opportunity to uncover the conserved systems-level mechanisms that give way to longevity in response to diet. Read More

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http://dx.doi.org/10.1016/j.mad.2019.02.003DOI Listing
April 2019
1 Read

Retraction notice to "Analysis of gut microbiota in long-lived older adults and their relatives: a gradual change with ageing" [YNBDI 178 (2019) 1 - 8].

Mech Ageing Dev 2019 03;178:R1

Department of General Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, No. 301 Yanchangzhong Road, Shanghai 200072, China. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2019.02.002DOI Listing

Comparative analysis of the gut microbiota in centenarians and young adults shows a common signature across genotypically non-related populations.

Mech Ageing Dev 2019 04 6;179:23-35. Epub 2019 Feb 6.

Microbial Resources Division, Institute of Bioresources and Sustainable Development (IBSD), Takyelpat Institutional Area, Imphal, 795 001, Manipur, India. Electronic address:

Gut microbiota is among the factors that may be involved in healthy aging. Broader and geographically spread studies on gut microbiota of centenarians can help in identifying a common signature of longevity. We identified an endogamous Indian population with high centenarian prevalence. Read More

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http://dx.doi.org/10.1016/j.mad.2019.02.001DOI Listing
April 2019
2 Reads

Cell cycle arrest in replicative senescence is not an immediate consequence of telomere dysfunction.

Mech Ageing Dev 2019 04 30;179:11-22. Epub 2019 Jan 30.

King's College London, Faculty of Life Sciences & Medicine, Department of Anatomy, Guy's Campus, LONDON SE1 1UL, UK; St George's, University of London, Molecular and Clinical Sciences Research Institute, Mailpoint J2A, Cranmer Terrace, London, SW17 0RE, UK. Electronic address:

In replicative senescence, cells with critically-short telomeres activate a DNA-damage response leading to cell-cycle arrest, while those without telomere dysfunction would be expected to cycle normally. However, population growth declines more gradually than such a simple binary switch between cycling and non-cycling states would predict. We show here that late-passage cultures of human fibroblasts are not a simple mixture of cycling and non-cycling cells. Read More

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http://dx.doi.org/10.1016/j.mad.2019.01.009DOI Listing

Rodent models of frailty and their application in preclinical research.

Mech Ageing Dev 2019 04 28;179:1-10. Epub 2019 Jan 28.

Department of Pharmacology, Dalhousie University, Halifax, NS, Canada; Department of Medicine (Geriatric Medicine), Dalhousie University, Halifax, NS, Canada. Electronic address:

In clinical medicine, the concept of frailty is viewed as a state of high vulnerability to adverse health outcomes in people of the same age. Frailty is an important challenge because the loss of physiological reserve means that even minor stressors can lead to disability and death in those who are frail. Even so, the biology of frailty is not well understood. Read More

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http://dx.doi.org/10.1016/j.mad.2019.01.008DOI Listing

Tauopathy: A common mechanism for neurodegeneration and brain aging.

Mech Ageing Dev 2019 03 19;178:72-79. Epub 2019 Jan 19.

Department of Neurological Surgery, University of Pittsburgh, 200 Lothrop Street, Scaife Hall, Pittsburgh, 15213, United States. Electronic address:

Tau, a microtubule-associated protein promotes assembly and stability of microtubules which is related to axoplasmic flow and critical neuronal activities upon physiological conditions. Under neurodegenerative condition such as in Alzheimer's Disease (AD), tau-microtubule binding dynamics and equilibrium are severely affected due to its aberrant post-translational modifications including acetylation and hyperphosphorylation. This event results in its conformational changes to form neurofibrillary tangles (NFT) after aggregation in the cytosol. Read More

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http://dx.doi.org/10.1016/j.mad.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377302PMC

Brain region-specific effects of long-term caloric restriction on redox balance of the aging rat.

Mech Ageing Dev 2019 04 16;179:51-59. Epub 2019 Jan 16.

Institut Armand-Frappier, INRS, 531 Bld des Prairies, Laval, QC, H7V 1B7, Canada; Institute of Nutrition and Functional Foods, Laval University, Quebec City, QC, G1V 4L3, Canada. Electronic address:

Caloric restriction (CR) is the most effective intervention to improve health span and extend lifespan in preclinical models. This anti-aging effect of CR is related to attenuation of oxidative damage in various tissues, with divergent results in the brain. We addressed how brain oxidoreductive balance would be modulated in male Sprague-Dawley (SD) rats submitted to a 40% CR from 8 to 19 months of age, by reference to ad libitum-fed (AL) rats at 2 and 19 months of age. Read More

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http://dx.doi.org/10.1016/j.mad.2019.01.002DOI Listing
April 2019
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Glycation interferes with natural killer cell function.

Mech Ageing Dev 2019 03 16;178:64-71. Epub 2019 Jan 16.

Institute for Physiological Chemistry, Martin-Luther-University Halle-Wittenberg, Hollystr. 1, D-06114, Halle/Saale, Germany.

One hallmark of molecular aging is glycation, better known as formation of so-called advanced glycation end products (AGEs), where reactive carbonyls react with amino-groups of proteins. AGEs accumulate over time and are responsible for various age-dependent diseases and impairments. Two very potent dicarbonyls to generate AGEs are glyoxal (GO) and methylglyoxal (MGO). Read More

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http://dx.doi.org/10.1016/j.mad.2019.01.006DOI Listing
March 2019
14 Reads

Apolipoprotein E gene in physiological and pathological aging.

Mech Ageing Dev 2019 03 15;178:41-45. Epub 2019 Jan 15.

Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy. Electronic address:

Introduction: The genetic background plays a role on longevity. The distribution of the apolipoprotein E gene (APOE) variants (ε2, ε3, ε4) may differ across age groups, especially in the oldest old and despite geographical and ethnic specificities. Since the ε4 variant is associated with Alzheimer's disease (AD), it might represent an opportunity for exploring the relationship of APOE with physiological and pathological aging. Read More

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http://dx.doi.org/10.1016/j.mad.2019.01.005DOI Listing
March 2019
1 Read

Resistin: A reappraisal.

Mech Ageing Dev 2019 03 14;178:46-63. Epub 2019 Jan 14.

DIMi, Department of Internal Medicine and medical specialties, Viale Benedetto XV, 6, 16132 University of Genoa, Genoa, Italy.

From a biological point of view, aging can be considered a progressive inability of an organism to react to stress, maintain homeostasis, and survive unfavourable changes during post-maturational life. The expression of several adipokines changes during aging and for some changes, a role in the onset of chronic disease and frailty has been proposed. Among adipokines, resistin was shown in recent studies to play a key role in aging. Read More

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http://dx.doi.org/10.1016/j.mad.2019.01.004DOI Listing
March 2019
2 Reads

Transcriptome profiling of human papillary and reticular fibroblasts from adult interfollicular dermis pinpoints the 'tissue skeleton' gene network as a component of skin chrono-ageing.

Mech Ageing Dev 2019 04 11;179:60-77. Epub 2019 Jan 11.

Advanced Research, L'Oréal Research and Innovation, 93600 Aulnay-sous-Bois, France.

Interactions between extracellular matrix (ECM) and fibroblasts are essential for maintaining dermis integrity, and are subject to ageing. The ötissue skeleton' network connects ECM to the nucleus and DNA, impacting nuclear shape and gene expression. In a previous Mech Ageing Dev publication, we have presented a transcriptomic study of papillary (Fp) and reticular (Fr) fibroblasts, with a main focus on Fp ageing. Read More

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http://dx.doi.org/10.1016/j.mad.2019.01.003DOI Listing
April 2019
12 Reads

Klotho gene polymorphisms are associated with healthy aging and longevity: Evidence from a meta-analysis.

Mech Ageing Dev 2019 03 10;178:33-40. Epub 2019 Jan 10.

Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Electronic address:

Klotho gene polymorphisms have been implicated in healthy aging, but inconsistences in findings from previous case-control studies have raised concerns regarding the associations between KLOTHO gene polymorphisms and susceptibility to aging-related diseases and longevity. Hence, this meta-analysis was performed. We assessed the associations between two polymorphisms (G-395 A/rs1207568 and F352 V/rs9536314) and five parameters (urolithiasis, cognitive impairment, cardiovascular disease, cancer, and longevity) by calculating pooled odds ratios with 95% confidence intervals. Read More

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http://dx.doi.org/10.1016/j.mad.2018.12.003DOI Listing
March 2019
19 Reads
3.397 Impact Factor

Lamin B receptor (LBR) is involved in the induction of cellular senescence in human cells.

Mech Ageing Dev 2019 03 4;178:25-32. Epub 2019 Jan 4.

Graduate School of Nanobioscience, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama, 236-0027, Japan; Ichiban Life Corporation, 1-1-7 Horai-cho, Naka-ku, Yokohama, 231-0048, Japan.

Cellular senescence is a phenomenon of irreversible growth arrest in mammalian somatic cells in culture. Various stresses induce cellular senescence and indeed, we have found that excess thymidine effectively induces cellular senescence in human cells. Further, many reports indicate the implication of chromatin proteins in cellular senescence. Read More

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http://dx.doi.org/10.1016/j.mad.2019.01.001DOI Listing
March 2019
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Where ageing goes nowadays: Mechanisms, pathways, biomarkers and anti-ageing strategies.

Mech Ageing Dev 2019 01 18;177:1-3. Epub 2018 Dec 18.

Institute for Biological Research "Sinisa Stankovic", University of Belgrade, Belgrade, Serbia. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2018.12.002DOI Listing
January 2019
8 Reads
3.700 Impact Factor

Role of MicroRNA-141 in the Aging Musculoskeletal System: A Current Overview.

Mech Ageing Dev 2019 03 7;178:9-15. Epub 2018 Dec 7.

Department of Orthopedics, Augusta University, Augusta, GA, United States; Institute of Regenerative and Reparative medicine, Augusta University, Augusta, GA, United States. Electronic address:

MicroRNA's are small non-coding RNAs that regulate the expression of genes by targeting the 3' UTR's of mRNA. Studies reveal that miRNAs play a pivotal role in normal musculoskeletal function such as mesenchymal stem cell differentiation, survivability and apoptosis, osteogenesis, and chondrogenesis. Changes in normal miRNA expression have been linked to a number of pathological disease processes. Read More

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http://dx.doi.org/10.1016/j.mad.2018.12.001DOI Listing
March 2019
3 Reads

Circular RNA involvement in aging: An emerging player with great potential.

Mech Ageing Dev 2019 03 1;178:16-24. Epub 2018 Dec 1.

Family Planning Research Institute/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. Electronic address:

Circular RNA (circRNA) is a class of newly discovered noncoding RNA (ncRNA), presenting as a special covalent loop without a 5' cap or 3' tail. Multiple biological properties of circRNA have been revealed during the past decades, such as widespread expression, high conservation, cell-specificity, tissue-specificity and developmental stage-specific expression patterns, as well as resistance to RNase R digestion. CircRNA also exhibits diverse biological functions, including regulation of host genes, alternative splicing, miRNA sponges, protein traps and even protein synthesis. Read More

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http://dx.doi.org/10.1016/j.mad.2018.11.002DOI Listing
March 2019
17 Reads

RETRACTED: Analysis of gut microbiota in long-lived older adults and their relatives: a gradual change with ageing.

Mech Ageing Dev 2019 03 22;178:1-8. Epub 2018 Nov 22.

Department of General Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, No. 301 Yanchangzhong Road, Shanghai 200072, China.

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http://dx.doi.org/10.1016/j.mad.2018.11.001DOI Listing
March 2019
11 Reads

Caloric restriction and cellular senescence.

Mech Ageing Dev 2018 12 3;176:19-23. Epub 2018 Nov 3.

University of Groningen, European Research Institute for the Biology of Aging, University Medical Center Groningen, Groningen, Netherlands. Electronic address:

Cellular senescence is a state of irreversible growth arrest characterized by hypertrophy and secretion of various bioactive molecules, a phenomenon defined the Senescence-Associated Secretory Phenotype (SASP). Senescent cells are implicated in a number of biological functions, from embryogenesis to aging. Significantly, excessive accumulation of senescent cells is associated to a decline of regenerative capacity and chronic inflammation. Read More

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http://dx.doi.org/10.1016/j.mad.2018.10.005DOI Listing
December 2018
15 Reads

Methionine restriction leads to hyperhomocysteinemia and alters hepatic HS production capacity in Fischer-344 rats.

Mech Ageing Dev 2018 12 25;176:9-18. Epub 2018 Oct 25.

Department of Biological Sciences, University of Manitoba, Winnipeg, MB, Canada; Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada; Centre on Aging, University of Manitoba, Winnipeg, MB, Canada. Electronic address:

Dietary methionine restriction (MR) increases lifespan in several animal models. Despite low dietary intake of sulphur amino acids, rodents on MR develop hyperhomocysteinemia. On the contrary, MR has been reported to increase HS production in mice. Read More

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http://dx.doi.org/10.1016/j.mad.2018.10.004DOI Listing
December 2018
18 Reads

Dietary Fibers and Their Fermented Short-Chain Fatty Acids in Prevention of Human Diseases.

Mech Ageing Dev 2018 Oct 15. Epub 2018 Oct 15.

Center for Occupational, Environmental Medicine, Department of Medicine, University of California, Irvine, CA, 92697, USA.

Many studies show that daily consumption of high-fiber diet is associated with a reduced risk of developing kidney stones, inflammatory disease, colon cancer and other malignancies, obesity, type II diabetes, and cardiovascular disease. Dietary fibers are non-digestible polysaccharides that are composed of complex carbohydrates. Based on their relative solubility in water, dietary fibers can be divided into insoluble and soluble forms. Read More

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http://dx.doi.org/10.1016/j.mad.2018.10.003DOI Listing
October 2018
9 Reads

Altered pheromone biosynthesis is associated with sex-specific changes in life span and behavior in Drosophila melanogaster.

Mech Ageing Dev 2018 12 10;176:1-8. Epub 2018 Oct 10.

Department of Biological Sciences, Southern Methodist University, 6501 Airline Road, Dallas, TX 75205, USA. Electronic address:

Many insect behaviors, including foraging, aggression, mating or group behavior, are tightly regulated by pheromones. Recently, it has been shown that pheromones may influence extreme longevity in the honeybee Apis mellifera, while changes in pheromone profile have been observed during ageing in Drosophila melanogaster. These data suggest a potential link between the pheromone system, behavior and longevity in insects. Read More

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http://dx.doi.org/10.1016/j.mad.2018.10.002DOI Listing
December 2018
54 Reads

Replicative aging as a source of cell heterogeneity in budding yeast.

Mech Ageing Dev 2018 12 4;176:24-31. Epub 2018 Oct 4.

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskiye Gory 1-40, Moscow 119991, Russia; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Leninskiye Gory 1-73, Moscow 119991, Russia; Institute of Mitoengineering MSU, Leninskiye Gory 1, Moscow 119991, Russia.

While deviations from the optimal phenotype are deleterious, increased variation can prevent population extinction under severe stresses. Cell division asymmetry is an important source of microbial phenotypic heterogeneity. A consecutive set of asymmetric divisions can cause the gradual accumulation of deleterious factors and, at late stages, the death of old pole (mother) cells. Read More

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http://dx.doi.org/10.1016/j.mad.2018.09.001DOI Listing
December 2018
2 Reads

Modelling physical resilience in ageing mice.

Mech Ageing Dev 2019 01 2;177:91-102. Epub 2018 Oct 2.

MRC/Arthritis Research-UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Department of Oncology and Metabolism, The Medical School, Beech Hill Road, Sheffield, S10 2RX, United Kingdom. Electronic address:

Geroprotectors, a class of drugs targeting multiple deficits occurring with age, necessitate the development of new animal models to test their efficacy. The COST Action MouseAGE is a European network whose aim is to reach consensus on the translational path required for geroprotectors, interventions targeting the biology of ageing. In our previous work we identified frailty and loss of resilience as a potential target for geroprotectors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00476374183011
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http://dx.doi.org/10.1016/j.mad.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445352PMC
January 2019
5 Reads

Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics.

Mech Ageing Dev 2019 01 19;177:4-21. Epub 2018 Aug 19.

University of Innsbruck, Innsbruck, Austria. Electronic address:

Key discoveries in aging research have been made possible with the use of model organisms. Caenorhabditis elegans is a short-lived nematode that has become a well-established system to study aging. The practicality and powerful genetic manipulations associated with this metazoan have revolutionized our ability to understand how organisms age. Read More

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http://dx.doi.org/10.1016/j.mad.2018.08.001DOI Listing
January 2019
4 Reads

Clinical and laboratory skin biomarkers of organ-specific diseases.

Mech Ageing Dev 2019 01 15;177:144-149. Epub 2018 Aug 15.

Derma Center Wildeshausen, 27793 Wildeshausen, Germany; Department of Dermatology and Allergology, Ulm University, 89081 Ulm, Germany.

Intense research during the last few years has elucidated a number of mechanisms of the complex human aging process. Among the body organs, skin has a distinguished role in aging perception both because it constitutes the organ on which the first signs of aging are mostly visible and because skin is recognized as an indicator of human health. Analogous to all other organs, skin undergoes multiple morphological and functional changes with age affected by extrinsic and intrinsic factors. Read More

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http://dx.doi.org/10.1016/j.mad.2018.08.003DOI Listing
January 2019
16 Reads

Cellular senescence in osteoarthritis and anti-aging strategies.

Mech Ageing Dev 2018 10 11;175:83-87. Epub 2018 Aug 11.

Orthopedics Research Institute of Chinese PLA, Beijing Key Lab of Regenerative Medicine in Orthopedics, General Hospital of Chinese PLA, Fuxing Road 28, Haidian District, Beijing 100853, PR China. Electronic address:

In older adults, the prevalence of osteoarthritis (OA) increases directly with age and is the most common cause of chronic disability. It is necessary to recognize that OA is a degenerative disease that strongly correlates with age, and often promotes elevated levels of cartilage injury. Chondrocytes undergo an age-dependent decline in proliferative and synthetic capacity. Read More

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http://dx.doi.org/10.1016/j.mad.2018.08.002DOI Listing
October 2018
3 Reads

HIV antiretroviral therapy drugs induce premature senescence and altered physiology in HUVECs.

Mech Ageing Dev 2018 10 25;175:74-82. Epub 2018 Jul 25.

Department of Pathology and Laboratory Medicine, Drexel University College of Medicine, Philadelphia, PA, USA. Electronic address:

Developments in medicine have led to a significant increase in the average human lifespan. This increase in aging is most readily apparent in the case of HIV where antiretroviral therapy has shifted infection from a terminal to a chronic but manageable disease. Despite this advance, patients suffer from co-morbidities best described as an accelerated aging phenotype. Read More

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http://dx.doi.org/10.1016/j.mad.2018.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133242PMC
October 2018
20 Reads

Oxaloacetate decarboxylase FAHD1 - a new regulator of mitochondrial function and senescence.

Mech Ageing Dev 2019 01 25;177:22-29. Epub 2018 Jul 25.

University of Innsbruck, Research Institute for Biomedical Ageing Research, Rennweg 10, A-6020 Innsbruck, Austria; University of Innsbruck, Center for Molecular Biosciences Innsbruck (CMBI), Innrain 80-82, A-6020 Innsbruck, Austria. Electronic address:

FAHD1, a member of the FAH superfamily of enzymes, was identified in a proteomic screen for mitochondrial proteins with differential expression in young versus senescent human endothelial cells. FAHD1 acts as oxaloacetate decarboxylase, and recent observations suggest that FAHD1 plays an important role in regulating mitochondrial function. Thus, mutation of the nematode homolog, fahd-1, impairs mitochondrial function in Caenorhabditis elegans. Read More

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http://dx.doi.org/10.1016/j.mad.2018.07.007DOI Listing
January 2019
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Regulation of metabolic health by essential dietary amino acids.

Mech Ageing Dev 2019 01 22;177:186-200. Epub 2018 Jul 22.

Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA. Electronic address:

Although the beneficial effects of calorie restriction (CR) on health and aging were first observed a century ago, the specific macronutrients and molecular processes that mediate the effect of CR have been heavily debated. Recently, it has become clear that dietary protein plays a key role in regulating both metabolic health and longevity, and that both the quantity and quality - the specific amino acid composition - of dietary protein mediates metabolic health. Here, we discuss recent findings in model organisms ranging from yeast to mice and humans regarding the influence of dietary protein as well as specific amino acids on metabolic health, and the physiological and molecular mechanisms which may mediate these effects. Read More

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http://dx.doi.org/10.1016/j.mad.2018.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333505PMC
January 2019
4 Reads

Iron status in the elderly: A review of recent evidence.

Mech Ageing Dev 2018 10 21;175:55-73. Epub 2018 Jul 21.

Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, UK. Electronic address:

A comprehensive literature review of iron status in the elderly was undertaken in order to update a previous review (Fairweather-Tait et al, 2014); 138 summarised papers describe research on the magnitude of the problem, aetiology and age-related physiological changes that may affect iron status, novel strategies for assessing iron status with concurrent health conditions, hepcidin, lifestyle factors, iron supplements, iron status and health outcomes (bone mineral density, frailty, inflammatory bowel disease, kidney failure, cancer, cardiovascular, and neurodegenerative diseases). Each section of this review concludes with key points from the relevant papers. The overall findings were that disturbed iron metabolism plays a major role in a large number of conditions associated with old age. Read More

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http://dx.doi.org/10.1016/j.mad.2018.07.003DOI Listing
October 2018
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Proinflammatory cytokines and ageing of the cardiovascular-renal system.

Mech Ageing Dev 2018 10 19;175:35-45. Epub 2018 Jul 19.

Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, the Medical University of Warsaw, Banacha 1B, 02-097 Warsaw, Poland. Electronic address:

Cardiovascular health deteriorates with age, and age is one of the strongest risk factors for cardiovascular complications including myocardial infarction, heart failure, cardiac arrhythmias, and death related to heart diseases. In this review, we show that expression of proinflammatory cytokines (PICs) increases throughout the human lifespan, and this increase is correlated with cardiovascular health, morbidity, and mortality. We argue that increased concentrations of circulating PICs are not only markers of chronic low-grade inflammation, but they also serve as an important pathophysiological link between CV health and ageing. Read More

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http://dx.doi.org/10.1016/j.mad.2018.07.006DOI Listing
October 2018
23 Reads

Stem cell rejuvenation and the role of autophagy in age retardation by caloric restriction: An update.

Mech Ageing Dev 2018 10 18;175:46-54. Epub 2018 Jul 18.

The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address:

Stem cells being pluripotent in nature can differentiate into a wide array of specific cells and asymmetrically divide to produce new ones but may undergo aging by themselves. Aging has both quantitative and qualitative effects on stem cells, and could eventually restrain them from replenishing into progenitor cells. Reactive oxygen species (ROS) accumulated in the aging cells could not only block the cell cycle but also affect autophagy by damaging the mitochondria. Read More

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http://dx.doi.org/10.1016/j.mad.2018.07.005DOI Listing
October 2018
2 Reads

Linker histones and chromatin remodelling complexes maintain genome stability and control cellular ageing.

Mech Ageing Dev 2019 01 17;177:55-65. Epub 2018 Jul 17.

Laboratory of Yeast Molecular Genetics, Institute of Molecular Biology "Acad. Roumen Tsanev", Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria. Electronic address:

Linker histones are major players in chromatin organization and per se are essential players in genome homeostasis. As the fifth class of histone proteins the linker histones not only interact with DNA and core histones but also with other chromatin proteins. These interactions prove to be essential for the higher levels of chromatin organization like chromatin loops, transcription factories and chromosome territories. Read More

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http://dx.doi.org/10.1016/j.mad.2018.07.002DOI Listing
January 2019
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From bed to bench: How in silico medicine can help ageing research.

Mech Ageing Dev 2019 01 10;177:103-108. Epub 2018 Jul 10.

INSIGNEO Institute for in silico Medicine, United Kingdom; Department of Oncology and Human Metabolism, University of Sheffield, United Kingdom.

Driven by the raising ethical concerns surrounding animal experimentation, there is a growing interest for non-animal methods, in vitro or in silico technologies that can be used to reduce, refine, and replace animal experimentation. In addition, animal experimentation is being critically revised in regard to its ability to predict clinical outcomes. In this manuscript we describe an initial exploration where a set of in vivo imaging based subject-specific technologies originally developed to predict the risk of femoral strength and hip fracture in osteoporotic patients, were adapted to assess the efficacy of bone drugs pre-clinically on mice. Read More

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http://dx.doi.org/10.1016/j.mad.2018.07.001DOI Listing
January 2019
15 Reads

Neural and musculotendinous mechanisms underpinning age-related force reductions.

Mech Ageing Dev 2018 10 8;175:17-23. Epub 2018 Jul 8.

Laboratório de Biomecânica, Centro de Desportos, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil. Electronic address:

Ageing leads to substantial force production capacity reductions, which is an indicator of frailty and disability, and a mortality predictor in elders. Understanding the age-dependent neuromuscular mechanisms underlying force reductions can optimize healthcare professionals' exercise protocol choices for patients and allows researchers to investigate new interventions to mitigate these reductions. Our primary goal was to provide an updated review about the main neural and musculotendinous mechanisms underpinning age-related reductions in force capacity. Read More

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http://dx.doi.org/10.1016/j.mad.2018.06.005DOI Listing
October 2018
6 Reads

Epigenetic and redox biomarkers: Novel insights from the MARK-AGE study.

Mech Ageing Dev 2019 01 30;177:128-134. Epub 2018 Jun 30.

Molecular Toxicology Group, Dept. of Biology, University of Konstanz, D-78457 Konstanz, Germany. Electronic address:

Ageing is a multifactorial process that affects most, if not all, of the body's tissues and organs and can be defined as the accumulation of physical and psychological changes in a human being over time. The rate of ageing differs between individuals of the same chronological age, meaning that 'biological age' of a person may be different from 'chronological age'. Furthermore, ageing represents a very potent risk factor for diseases and disability in humans. Read More

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http://dx.doi.org/10.1016/j.mad.2018.06.006DOI Listing
January 2019
2 Reads